18 results on '"Van Den Branden, Ben J L"'
Search Results
2. Prognostic Value of Histopathological Thrombus Age in Large Vessel Occlusion-Related Stroke
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Team Medisch, Gorsel, Bart Van, Remmers, Michel J M, Vos, Louwerens D, Scholzel, Bas E, Haans, Dirk A W, Aarts, Ruud A H M, Versteylen, Rob J, Van Norden, Anouk G W, Van Oers, Casper A M M, Vos, Jeroen, IJsselmuiden, Sander J J, Van Den Branden, Ben J L, De Boer, Onno J, Imani, Farshad, Alings, Marco, Pertiwi, Kartika R, De Winter, Robbert J, Miah, Ishita, Van Der Wal, Allard C, Van De Hoef, Tim P, Meuwissen, Martijn, Team Medisch, Gorsel, Bart Van, Remmers, Michel J M, Vos, Louwerens D, Scholzel, Bas E, Haans, Dirk A W, Aarts, Ruud A H M, Versteylen, Rob J, Van Norden, Anouk G W, Van Oers, Casper A M M, Vos, Jeroen, IJsselmuiden, Sander J J, Van Den Branden, Ben J L, De Boer, Onno J, Imani, Farshad, Alings, Marco, Pertiwi, Kartika R, De Winter, Robbert J, Miah, Ishita, Van Der Wal, Allard C, Van De Hoef, Tim P, and Meuwissen, Martijn
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- 2023
3. Professionals’ views on shared decision-making in severe aortic stenosis
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van Beek-Peeters, Judith J A M, primary, van der Meer, Jop B L, additional, Faes, Miriam C, additional, de Vos, Annemarie J B M, additional, van Geldorp, Martijn W A, additional, Van den Branden, Ben J L, additional, Pel-Littel, Ruth E, additional, van der Meer, Nardo J M, additional, and Minkman, Mirella M N, additional
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- 2021
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4. Professionals' views on shared decision-making in severe aortic stenosis.
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van Beek-Peeters, Judith J. A. M., van der Meer, Jop B. L., Faes, Miriam C., de Vos, Annemarie J. B. M., van Geldorp, Martijn W. A., Van den Branden, Ben J. L., Pel-Littel, Ruth E., van der Meer, Nardo J. M., and Minkman, Mirella M. N.
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AORTIC stenosis ,COMMUNICATIVE disorders ,PATIENTS' attitudes ,MEDICAL personnel as patients - Abstract
Objective: To provide insight into professionals' perceptions of and experiences with shared decision-making (SDM) in the treatment of symptomatic patients with severe aortic stenosis (AS).Methods: A semistructured interview study was performed in the heart centres of academic and large teaching hospitals in the Netherlands between June and December 2020. Cardiothoracic surgeons, interventional cardiologists, nurse practitioners and physician assistants (n=21) involved in the decision-making process for treatment of severe AS were interviewed. An inductive thematic analysis was used to identify, analyse and report patterns in the data.Results: Four primary themes were generated: (1) the concept of SDM, (2) knowledge, (3) communication and interaction, and (4) implementation of SDM. Not all respondents considered patient participation as an element of SDM. They experienced a discrepancy between patients' wishes and treatment options. Respondents explained that not knowing patient preferences for health improvement hinders SDM and complicating patient characteristics for patient participation were perceived. A shared responsibility for improving SDM was suggested for patients and all professionals involved in the decision-making process for severe AS.Conclusions: Professionals struggle to make highly complex treatment decisions part of SDM and to embed patients' expectations of treatment and patients' preferences. Additionally, organisational constraints complicate the SDM process. To ensure sustainable high-quality care, professionals should increase their awareness of patient participation in SDM, and collaboration in the pathway for decision-making in severe AS is required to support the documentation and availability of information according to the principles of SDM. [ABSTRACT FROM AUTHOR]- Published
- 2022
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5. Percutaneous Atrial Shunt Closure Using the Novel Occlutech Figulla Device: 6-Month Efficacy and Safety
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VAN DEN BRANDEN, BEN J. L., POST, MARTIJN C., PLOKKER, HERBERT W. M., TEN BERG, JURRIËN M., and SUTTORP, MAARTEN J.
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- 2011
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6. Late catch-up in lumen diameter at five-year angiography in MACE-free patients treated with sirolimus-eluting stents in the Primary Stenting of Totally Occluded Native Coronary Arteries: a randomised comparison of bare metal stent implantation with sirolimus-eluting stent implantation for the treatment of total coronary occlusions (PRISON II)
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Teeuwen, Koen, primary, Van den Branden, Ben J. L., additional, Rahel, Braim M., additional, Laarman, Gerrit J., additional, Tijssen, Jan G. P., additional, Kelder, Johannes C., additional, Slagboom, Ton, additional, ten Berg, Juriën M., additional, and Suttorp, Maarten J., additional
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- 2013
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7. Percutaneous Atrial Shunt Closure Using the Novel Occlutech Figulla Device: 6‐Month Efficacy and Safety
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VAN DEN BRANDEN, BEN J. L., primary, POST, MARTIJN C., additional, PLOKKER, HERBERT W. M., additional, TEN BERG, JURRIËN M., additional, and SUTTORP, MAARTEN J., additional
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- 2010
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8. Continuation versus Interruption of Oral Anticoagulation during TAVI.
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van Ginkel DJ, Bor WL, Aarts HM, Dubois C, De Backer O, Rooijakkers MJP, Rosseel L, Veenstra L, van der Kley F, van Bergeijk KH, Van Mieghem NM, Agostoni P, Voskuil M, Schotborgh CE, IJsselmuiden AJJ, Van Der Heyden JAS, Hermanides RS, Barbato E, Mylotte D, Fabris E, Frambach P, Dujardin K, Ferdinande B, Peper J, Rensing BJWM, Timmers L, Swaans MJ, Brouwer J, Nijenhuis VJ, Overduin DC, Adriaenssens T, Kobari Y, Vriesendorp PA, Montero-Cabezas JM, El Jattari H, Halim J, Van den Branden BJL, Leonora R, Vanderheyden M, Lauterbach M, Wykrzykowska JJ, van 't Hof AWJ, van Royen N, Tijssen JGP, Delewi R, and Ten Berg JM
- Abstract
Background: One third of patients undergoing transcatheter aortic-valve implantation (TAVI) have an indication for oral anticoagulation owing to concomitant diseases. Interruption of oral anticoagulation during TAVI may decrease the risk of bleeding, whereas continuation may decrease the risk of thromboembolism., Methods: We conducted an international, open-label, randomized, noninferiority trial involving patients who were receiving oral anticoagulants and were planning to undergo TAVI. Patients were randomly assigned in a 1:1 ratio to periprocedural continuation or interruption of oral anticoagulation. The primary outcome was a composite of death from cardiovascular causes, stroke from any cause, myocardial infarction, major vascular complications, or major bleeding within 30 days after TAVI., Results: A total of 858 patients were included in the modified intention-to-treat population: 431 were assigned to continuation and 427 to interruption of oral anticoagulation. A primary-outcome event occurred in 71 patients (16.5%) in the continuation group and in 63 (14.8%) in the interruption group (risk difference, 1.7 percentage points; 95% confidence interval [CI], -3.1 to 6.6; P = 0.18 for noninferiority). Thromboembolic events occurred in 38 patients (8.8%) in the continuation group and in 35 (8.2%) in the interruption group (risk difference, 0.6 percentage points; 95% CI, -3.1 to 4.4). Bleeding occurred in 134 patients (31.1%) in the continuation group and in 91 (21.3%) in the interruption group (risk difference, 9.8 percentage points; 95% CI, 3.9 to 15.6)., Conclusions: In patients undergoing TAVI with a concomitant indication for oral anticoagulation, periprocedural continuation was not noninferior to interruption of oral anticoagulation during TAVI with respect to the incidence of a composite of death from cardiovascular causes, stroke, myocardial infarction, major vascular complications, or major bleeding at 30 days. (Funded by the Netherlands Organization for Health Research and Development and the St. Antonius Research Fund; POPular PAUSE TAVI ClinicalTrials.gov number, NCT04437303.)., (Copyright © 2024 Massachusetts Medical Society.)
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- 2024
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9. Prognostic Value of Histopathological Thrombus Age in Large Vessel Occlusion-Related Stroke.
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Gorsel BV, Remmers MJM, Vos LD, Scholzel BE, Haans DAW, Aarts RAHM, Versteylen RJ, Van Norden AGW, Van Oers CAMM, Vos J, IJsselmuiden SJJ, Van Den Branden BJL, De Boer OJ, Imani F, Alings M, Pertiwi KR, De Winter RJ, Miah I, Van Der Wal AC, Van De Hoef TP, and Meuwissen M
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- Humans, Prognosis, Thrombectomy adverse effects, Treatment Outcome, Retrospective Studies, Stroke diagnostic imaging, Stroke etiology, Brain Ischemia diagnostic imaging, Brain Ischemia therapy, Endovascular Procedures adverse effects, Thrombosis diagnostic imaging, Thrombosis therapy, Ischemic Stroke diagnostic imaging, Ischemic Stroke etiology, Arterial Occlusive Diseases complications
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Introduction: Acute mechanical thrombectomy (MT) is the preferred treatment for large vessel occlusion-related stroke. Histopathological research on the obtained occlusive embolic thrombus may provide information regarding the aetiology and pathology of the lesion to predict prognosis and propose possible future acute ischaemic stroke therapy., Methods: A total of 75 consecutive patients who presented to the Amphia Hospital with acute large vessel occlusion-related stroke and underwent MT were included in the study. The obtained thrombus materials were subjected to standard histopathological examination. Based on histological criteria, they were considered fresh (<1 day old) or old (>1 day old). Patients were followed for 2 years for documentation of all-cause mortality., Results: Thrombi were classified as fresh in 40 patients (53%) and as older in 35 patients (47%). Univariate Cox regression analysis showed that thrombus age, National Institutes of Health Stroke Scale at hospital admission, and patient age were associated with long-term mortality (p < 0.1). Multivariable Cox hazards and Kaplan-Meier analysis demonstrated that after extensive adjustment for clinical and procedural variables, thrombus age persisted in being independently associated with higher long-term mortality (hazard ratio: 3.34; p = 0.038, log-rank p = 0.013)., Conclusion: In this study, older thromboemboli are responsible for almost half of acute large ischaemic strokes. Moreover, the presence of an old thrombus is an independent predictor of mortality in acute large vessel occlusion-related stroke. More research is warranted regarding future therapies based on thrombus composition., (© 2023 The Author(s). Published by S. Karger AG, Basel.)
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- 2023
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10. Use of Lithotripsy in a Calcified Saphenous Vein Graft.
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van Gameren M, Vos J, IJsselmuiden AJJ, Van den Branden BJL, Meuwissen M, den Heijer P, and Schölzel BE
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Percutaneous coronary interventions in saphenous vein grafts can pose a variety of challenges, such as severely calcified lesions. If these lesions are nondilatable, lithotripsy can arguably be a proper tool for lesion preparation. We present a case in which a nondilatable, calcified saphenous vein graft was successfully treated using Shockwave lithotripsy. ( Level of Difficulty: Intermediate. )., Competing Interests: The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (© 2020 The Authors.)
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- 2020
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11. Comparison of Outcome After Percutaneous Mitral Valve Repair With the MitraClip in Patients With Versus Without Atrial Fibrillation.
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Velu JF, Kortlandt FA, Hendriks T, Schurer RAJ, van Boven AJ, Koch KT, Vis MM, Henriques JP, Piek JJ, Van den Branden BJL, Schaap J, Rensing BJ, Swaans MJ, Bouma BJ, Van der Heyden JAS, and Baan J Jr
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- Aged, Aged, 80 and over, Atrial Fibrillation mortality, Atrial Fibrillation physiopathology, Echocardiography, Transesophageal, Electrocardiography, Female, Humans, Incidence, Kaplan-Meier Estimate, Male, Middle Aged, Mitral Valve diagnostic imaging, Mitral Valve Insufficiency complications, Mitral Valve Insufficiency mortality, Netherlands epidemiology, Prosthesis Design, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Atrial Fibrillation complications, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation methods, Mitral Valve surgery, Mitral Valve Insufficiency surgery, Postoperative Complications epidemiology, Ventricular Function, Left physiology
- Abstract
Percutaneous mitral valve repair with the MitraClip is an established treatment for patients with mitral regurgitation (MR) who are inoperable or at high risk for surgery. Atrial Fibrillation (AF) frequently coincides with MR, but only scarce data of the influence of AF on outcome after MitraClip is available. The aim of the current study was to compare the clinical outcome after MitraClip treatment in patients with versus without atrial fibrillation. Between January 2009 and January 2016, all consecutive patients treated with a MitraClip in 5 Dutch centers were included. Outcome measures were survival, symptoms, MR grade, and stroke incidence. In total, 618 patients were treated with a MitraClip. Patients with AF were older, had higher N-terminal B-type natriuretic peptide levels, more tricuspid regurgitation, less often coronary artery disease and a better left ventricular function. Survival of patients treated with the MitraClip was similar for patients with AF (82%) and without AF (non-AF; 85%) after 1 year (p = 0.30), but significantly different after 5-year follow-up (AF 34%; non-AF 47%; p = 0.006). After 1 month, 64% of the patients with AF were in New York Heart Association class I or II, in contrast to 77% of the patients without AF (p = 0.001). The stroke incidence appeared not to be significantly different (AF 1.8%; non-AF 1.0%; p = 0.40). In conclusion, patients with AF had similar 1-year survival, MR reduction, and stroke incidence compared with non-AF patients. However, MitraClip patients with AF had reduced long-term survival and remained more symptomatic compared with those without AF., (Copyright © 2017 Elsevier Inc. All rights reserved.)
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- 2017
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12. Percutaneous Mitral Valve Repair: Refining Selection Criteria.
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Velu JF, Kortlandt FA, Hendriks T, Schurer RAJ, van Boven AJ, Van den Branden BJL, Van der Heyden JAS, Bouma BJ, Rensing BJ, and Baan J Jr
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- Aged, Aged, 80 and over, Female, Humans, Male, Cardiac Catheterization methods, Heart Valve Prosthesis Implantation methods, Mitral Valve surgery, Mitral Valve Insufficiency surgery, Patient Selection
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- 2017
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13. Three-year clinical outcome in the Primary Stenting of Totally Occluded Native Coronary Arteries III (PRISON III) trial: a randomised comparison between sirolimus-eluting stent implantation and zotarolimus-eluting stent implantation for the treatment of total coronary occlusions.
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Teeuwen K, Van den Branden BJ, Koolen JJ, van der Schaaf RJ, Henriques JP, Tijssen JG, Kelder JC, Vermeersch PH, Rensing BJ, and Suttorp MJ
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- Aged, Cardiovascular Diseases mortality, Coronary Occlusion drug therapy, Coronary Restenosis epidemiology, Female, Humans, Longitudinal Studies, Male, Middle Aged, Myocardial Infarction epidemiology, Myocardial Revascularization statistics & numerical data, Percutaneous Coronary Intervention instrumentation, Reoperation, Thrombosis epidemiology, Antibiotics, Antineoplastic therapeutic use, Coronary Occlusion surgery, Drug-Eluting Stents, Sirolimus analogs & derivatives, Sirolimus therapeutic use
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Aims: Sirolimus-eluting stents (SES) have been shown to be superior to Endeavor zotarolimus-eluting stents (ZES) and comparable to Resolute ZES at eight-month angiography in patients treated for total coronary occlusions (TCO). This study investigated clinical outcome at three-year follow-up., Methods and Results: The PRISON III trial investigated the efficacy and safety of SES against ZES (Endeavor and Resolute) in two study phases. In the first phase, 51 patients were randomised to receive SES and 46 to Endeavor ZES. In the second phase, 103 and 104 patients were randomised to SES or Resolute ZES, respectively. Between one and three years there were only a few additional clinical events in all groups. As a result, the rates of target lesion revascularisation 12.2% vs. 19.6%, p=0.49, target vessel failure 14.3% vs. 19.6%, p=0.68, and definite or probable stent thrombosis 4.1% vs. 2.2% were comparable between SES and Endeavor ZES at three years. In the second study phase, the rates of target lesion revascularisation 10% vs. 5.9%, p=0.42, target vessel failure 10% vs. 7.9%, p=0.79 and definite or probable stent thrombosis 1.0% vs. 0% were similar between SES and Resolute ZES., Conclusions: The present study demonstrated a low incidence of clinical events between one- and three-year follow-up with either SES compared to Endeavor ZES or SES versus Resolute ZES in patients treated for total coronary occlusions.
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- 2015
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14. Primary Stenting of Totally Occluded Native Coronary Arteries III (PRISON III): a randomised comparison of sirolimus-eluting stent implantation with zotarolimus-eluting stent implantation for the treatment of total coronary occlusions.
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Van den Branden BJ, Teeuwen K, Koolen JJ, van der Schaaf RJ, Henriques JP, Tijssen JG, Kelder JC, Vermeersch PH, Rensing BJ, and Suttorp MJ
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- Coronary Angiography, Coronary Restenosis, Coronary Vessels, Humans, Prospective Studies, Sirolimus, Treatment Outcome, Coronary Occlusion, Drug-Eluting Stents
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Aims: We investigated whether sirolimus-eluting stents (SES) are superior to next-generation zotarolimus-eluting stents (ZES) in treating patients with total coronary occlusions (TCO)., Methods and Results: In a prospective, randomised trial we compared the SES with the zotarolimus-eluting stent (ZES; Endeavor or Resolute) after successful recanalisation of TCO. During the first phase of the trial, 51 patients were assigned to receive the SES and 46 patients to receive the Endeavor ZES. In the second phase we randomised 103 patients to the SES group and 104 patients to the Resolute ZES group. The primary endpoint was in-segment late lumen loss at eight-month follow-up. At eight months, patients in the SES group had less in-segment and in-stent late loss as compared to the Endeavor group: -0.13±0.3 mm vs. 0.27±0.6 mm (p=0.0002) and -0.13±0.5 mm vs. 0.54±0.5 mm (p<0.0001), respectively. In contrast, the SES and the Resolute ZES showed comparable amounts of in-segment (-0.03±0.7 mm vs. -0.10±0.7 mm, p=0.6) and in-stent (0.03±0.8 mm vs. 0.05±0.8 mm, p=0.9) late loss., Conclusions: In the treatment of TCOs, the SES was associated with superior angiographic outcomes compared to the Endeavor ZES. On the other hand, the SES and the Resolute ZES showed comparable angiographic outcomes.
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- 2013
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15. A randomized multicenter comparison of hybrid sirolimus-eluting stents with bioresorbable polymer versus everolimus-eluting stents with durable polymer in total coronary occlusion: rationale and design of the Primary Stenting of Occluded Native Coronary Arteries IV study.
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Teeuwen K, Adriaenssens T, Van den Branden BJ, Henriques JP, Van der Schaaf RJ, Koolen JJ, Vermeersch PH, Bosschaert MA, Tijssen JG, and Suttorp MJ
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- Angioplasty, Balloon, Coronary adverse effects, Belgium, Clinical Protocols, Coronary Angiography, Coronary Occlusion diagnosis, Coronary Restenosis diagnosis, Coronary Restenosis etiology, Coronary Vessels diagnostic imaging, Coronary Vessels pathology, Everolimus, Humans, Neointima, Netherlands, Prospective Studies, Prosthesis Design, Single-Blind Method, Sirolimus administration & dosage, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Angioplasty, Balloon, Coronary instrumentation, Cardiovascular Agents administration & dosage, Coronary Occlusion therapy, Drug-Eluting Stents, Polymers, Research Design, Sirolimus analogs & derivatives
- Abstract
Background: Percutaneous recanalization of total coronary occlusion (TCO) was historically hampered by high rates of restenosis and reocclusions. The PRISON II trial demonstrated a significant restenosis reduction in patients treated with sirolimus-eluting stents compared with bare metal stents for TCO. Similar reductions in restenosis were observed with the second-generation zotarolimus-eluting stent and everolimus-eluting stent. Despite favorable anti-restenotic efficacy, safety concerns evolved after identifying an increased rate of very late stent thrombosis (VLST) with drug-eluting stents (DES) for the treatment of TCO. Late malapposition caused by hypersensitivity reactions and chronic inflammation was suggested as a probable cause of these VLST. New DES with bioresorbable polymer coatings were developed to address these safety concerns. No randomized trials have evaluated the efficacy and safety of the new-generation DES with bioresorbable polymers in patients treated for TCO., Methods/design: The prospective, randomized, single-blinded, multicenter, non-inferiority PRISON IV trial was designed to evaluate the safety, efficacy, and angiographic outcome of hybrid sirolimus-eluting stents with bioresorbable polymers (Orsiro; Biotronik, Berlin, Germany) compared with everolimus-eluting stents with durable polymers (Xience Prime/Xpedition; Abbott Vascular, Santa Clara, CA, USA) in patients with successfully recanalized TCOs. In total, 330 patients have been randomly allocated to each treatment arm. Patients are eligible with estimated duration of TCO ≥4 weeks with evidence of ischemia in the supply area of the TCO. The primary endpoint is in-segment late luminal loss at 9-month follow-up angiography. Secondary angiographic endpoints include in-stent late luminal loss, minimal luminal diameter, percentage of diameter stenosis, in-stent and in-segment binary restenosis and reocclusions at 9-month follow-up. Additionally, optical coherence tomography is performed in the first 60 randomized patients at 9 months to assess neointima thickness, percentage of neointima coverage, and stent strut malapposition and coverage. Personnel blinded to the allocated treatment will review all angiographic and optical coherence assessments. Secondary clinical endpoints include major adverse cardiac events, clinically driven target vessel revascularization, target vessel failure and stent thrombosis to 5-year clinical follow-up. An independent clinical event committee blinded to the allocated treatment will review all clinical events., Trial Registration: Clinical Trials.gov: NCT01516723. Patient recruitment started in February 2012.
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- 2012
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16. Five-year clinical outcome after primary stenting of totally occluded native coronary arteries: a randomised comparison of bare metal stent implantation with sirolimus-eluting stent implantation for the treatment of total coronary occlusions (PRISON II study).
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Van den Branden BJ, Rahel BM, Laarman GJ, Slagboom T, Kelder JC, Ten Berg JM, and Suttorp MJ
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- Aged, Angioplasty, Balloon, Coronary instrumentation, Cohort Studies, Coronary Restenosis epidemiology, Female, Follow-Up Studies, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Myocardial Infarction epidemiology, Survival Rate, Thrombosis epidemiology, Thrombosis etiology, Treatment Outcome, Angioplasty, Balloon, Coronary methods, Coronary Occlusion mortality, Coronary Occlusion therapy, Drug-Eluting Stents adverse effects, Metals, Sirolimus, Stents adverse effects
- Abstract
Aims: The aim of this study was to examine the five-year clinical outcome in patients enrolled in the Primary Stenting of Totally Occluded Native Coronary Arteries II (PRISON II) study., Methods and Results: Patients with totally occluded coronary arteries were randomised to either sirolimus-eluting stent (SES, n=100) or bare metal stent (BMS, n=100) implantation. At five years, patients in the SES group had significantly lower rates of target lesion revascularisation (12% vs. 30%, p=0.001), target vessel revascularisation (17% vs. 34%, p=0.009) and major adverse cardiac events (12% vs. 36%, p<0.001). There were no significant differences in death and myocardial infarction. Eight (8%) cases of stent thrombosis (seven definite and one probable; one early, one late, and six very late) were noticed in the SES group versus three cases (3%, one definite and two possible; all very late) in the BMS group (p=0.21)., Conclusions: The results of the present study show that the documented superior short-term angiographic and clinical results of SES in patients with total coronary occlusions are maintained during long-term 5-year follow-up as compared with BMS. On the other hand, there is a trend to a higher stent thrombosis rate in the SES group.
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- 2012
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17. Percutaneous edge-to-edge mitral valve repair in high-surgical-risk patients: do we hit the target?
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Van den Branden BJ, Swaans MJ, Post MC, Rensing BJ, Eefting FD, Jaarsma W, and Van der Heyden JA
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- Aged, Catheterization adverse effects, Catheterization instrumentation, Echocardiography, Exercise Test, Female, Health Status Indicators, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases surgery, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis Implantation instrumentation, Humans, Male, Mitral Valve diagnostic imaging, Mitral Valve surgery, Prognosis, Quality of Life, Risk Assessment, Severity of Illness Index, Stroke Volume, Surveys and Questionnaires, Ventricular Function, Left, Catheterization methods, Heart Valve Diseases pathology, Heart Valve Prosthesis Implantation methods, Mitral Valve pathology
- Abstract
Objectives: This study sought to assess the feasibility and safety of percutaneous edge-to-edge mitral valve (MV) repair in patients with an unacceptably high operative risk., Background: MV repair for mitral regurgitation (MR) can be accomplished by use of a clip that approximates the free edges of the mitral leaflets., Methods: All patients were declined for surgery because of a high logistic EuroSCORE (>20%) or the presence of other specific surgical risk factors. Transthoracic echocardiography was performed before and 6 months after the procedure. Differences in New York Heart Association (NYHA) functional class, quality of life (QoL) using the Minnesota questionnaire, and 6-min walk test (6-MWT) distances were reported., Results: Fifty-five procedures were performed in 52 patients (69.2% male, age 73.2 ± 10.1 years, logistic EuroSCORE 27.1 ± 17.0%). In 3 patients, partial clip detachment occurred; a second clip was placed successfully. One patient experienced cardiac tamponade. Two patients developed inguinal bleeding, of whom 1 needed surgery. Six patients (11.5%) died during 6-month follow-up (5 patients as a result of progressive heart failure and 1 noncardiac death). The MR grade before repair was ≥3 in 100%; after 6 months, a reduction in MR grade to ≤2 was present in 79% of the patients. Left ventricular (LV) end-diastolic diameter, LV ejection fraction, and systolic pulmonary artery pressure improved significantly. Accompanied improvements in NYHA functional class, QoL index, 6-MWT distances, and log N-terminal pro-B-type natriuretic peptide were observed., Conclusions: In a high-risk population, MR reduction can be achieved by percutaneous edge-to-edge valve repair, resulting in LV remodeling with improvement of functional capacity after 6 months., (Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
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- 2012
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18. Redo mitral valve clipping after partial clip detachment.
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Van den Branden BJ, Swaans MJ, Post MC, Rensing BJ, Eefting FD, Jaarsma W, and Van der Heyden JA
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- Echocardiography, Transesophageal, Foreign Bodies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mitral Valve diagnostic imaging, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency pathology, Stroke Volume, Ventricular Function, Left, Cardiac Catheterization, Mitral Valve pathology, Mitral Valve Insufficiency therapy
- Published
- 2010
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