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2. 'Now It Is about Me Having to Learn Something ….' Partners' Experiences with a Dutch Conversation Partner Training Programme (PACT)

Author

Wielaert, Sandra M., Berns, Philine, van de Sandt-Koenderman, Mieke W. M. E., Dammers, Nina, and Sage, Karen

Abstract

Background: The increase in the number of reported conversation partner programmes for conversation partners of people with aphasia demonstrates increased awareness of partner needs and the positive effect of trained partners on the communicative abilities of the person with aphasia. Predominantly small-scale studies describe the effectiveness of conversation partner training (CPT) and how partners perceive this training. The view of partners on this service commission remains largely unknown. Aims: To explore the experiences of partners of people with aphasia with a CPT programme when it was newly introduced into rehabilitation settings. Methods & Procedures: Seventeen partners of people with aphasia were interviewed using a semi-structured format about their experience with Partners of Aphasic Clients Conversation Training (PACT). Transcribed interviews were analysed using qualitative content analysis. Outcomes & Results: Four categories representative of the practical nature and individual tailoring of PACT were identified: engaging with PACT; learning from PACT; reflecting on behaviour and emotions; and experiences with earlier speech and language therapy (SLT). Two themes were identified cutting across all categories: the nature of communication is difficult to grasp; and balancing roles as partner, carer and client. Conclusions & Implications: Partners appreciated the training programme once their initial lack of awareness of the interactive nature of communication had been addressed. SLTs need to be clear about the collaborative nature of conversations and what can be offered within the rehabilitation trajectory to address conversation alongside language training.

Published
2017
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4. Pantomime Production by People with Aphasia: What Are Influencing Factors?

Author

van Nispen, Karin, van de Sandt-Koenderman, Mieke, and Mol, Lisette

Abstract

Purpose: The present article aimed to inform clinical practice on whether people with aphasia (PWA) deploy pantomime techniques similarly to participants without brain damage (PWBD) and if not, what factors influence these differences. Method: We compared 38 PWA to 20 PWBD in their use of 6 representation techniques ("handling," "enact," "object," "shape," "deictic," and "other") when pantomiming objects, and determined whether PWA used the same defaults as PWBD. We assessed the influence of "(non-)dominant arm use," "ideomotor apraxia," "semantic processing," "aphasia severity," and "oral naming." Results: PWA used various pantomime techniques. Enact, deictic, and other were used infrequently. No differences were found for the use of shape techniques, but PWA used fewer handling and object techniques than PWBD and they did not use these for the same objects as PWBD did. No influence was found for (non-)dominant arm use. All other variables correlated with the use of handling, object, and defaults. Conclusion: In our study, PWA were able to use various pantomime techniques. As a group, they used these techniques differently from PWBD and relied more heavily on the use of shape techniques. This was not influenced by a hemiparesis, but seemed dependent on semantic processing. Clinical implications are discussed.

Published
2016
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6. Scoring en interpretatie

Author

Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, Hachioui, Hanane el, Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, and Hachioui, Hanane el

Published
2010
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7. Psychometrisch onderzoek

Author

Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, Hachioui, Hanane el, Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, and Hachioui, Hanane el

Published
2010
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8. Afname

Author

Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, Hachioui, Hanane el, Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, and Hachioui, Hanane el

Published
2010
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9. Afname

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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10. Validiteit

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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11. Meetpretentie

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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12. Betrouwbaarheid

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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13. Scoring en interpretatie

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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14. Doel en inhoud

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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16. Should Pantomime and Gesticulation Be Assessed Separately for Their Comprehensibility in Aphasia? A Case Study

Author

van Nispen, Karin, van de Sandt-Koenderman, Mieke, and Mol, Lisette

Abstract

Background: Gesticulation (gestures accompanying speech) and pantomime (gestures in the absence of speech) can each be comprehensible. Little is known about the differences between these two gesture modes in people with aphasia. Aims: To discover whether there are differences in the communicative use of gesticulation and pantomime in QH, a person with severe fluent aphasia. Methods & Procedures: QH performed two tasks: naming objects and retelling a story. He did this once in a verbal condition (enabling gesticulation) and once in a pantomime condition. For both conditions, the comprehensibility of gestures was analysed in a forced-choice task by naïve judges. Secondly, a comparison was made between QH and healthy controls for the representation techniques used. Outcomes & Results: Pantomimes produced by QH for naming objects were significantly more comprehensible than chance, whereas his gesticulation was not. For retelling a story the opposite pattern was found. When naming objects QH gesticulated much more than did healthy controls. His pantomimes for this task were simpler than those used by the control group. For retelling a story no differences were found. Conclusions & Implications: Although QH did not make full use of each gesture modes' potential, both did contribute to QH's comprehensibility. Crucially, the benefits of each mode differed across tasks. This implies that both gesture modes should be taken into account separately in models of speech and gesture production and in clinical practice for different communicative settings.

Published
2014
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17. Theoretische achtergrond

Author

Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, Hachioui, Hanane el, Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, and Hachioui, Hanane el

Published
2010
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18. Beschrijving van de ScreeLing

Author

Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, Hachioui, Hanane el, Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, and Hachioui, Hanane el

Published
2010
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19. Communicatie: achtergrond en onderzoeksbevindingen

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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20. Complex speech-language therapy interventions for stroke-related aphasia: the RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author

Brady, Marian C, primary, Ali, Myzoon, additional, VandenBerg, Kathryn, additional, Williams, Linda J, additional, Williams, Louise R, additional, Abo, Masahiro, additional, Becker, Frank, additional, Bowen, Audrey, additional, Brandenburg, Caitlin, additional, Breitenstein, Caterina, additional, Bruehl, Stefanie, additional, Copland, David A, additional, Cranfill, Tamara B, additional, di Pietro-Bachmann, Marie, additional, Enderby, Pamela, additional, Fillingham, Joanne, additional, Galli, Federica Lucia, additional, Gandolfi, Marialuisa, additional, Glize, Bertrand, additional, Godecke, Erin, additional, Hawkins, Neil, additional, Hilari, Katerina, additional, Hinckley, Jacqueline, additional, Horton, Simon, additional, Howard, David, additional, Jaecks, Petra, additional, Jefferies, Elizabeth, additional, Jesus, Luis MT, additional, Kambanaros, Maria, additional, Kang, Eun Kyoung, additional, Khedr, Eman M, additional, Kong, Anthony Pak-Hin, additional, Kukkonen, Tarja, additional, Laganaro, Marina, additional, Lambon Ralph, Matthew A, additional, Laska, Ann Charlotte, additional, Leemann, Béatrice, additional, Leff, Alexander P, additional, Lima, Roxele R, additional, Lorenz, Antje, additional, MacWhinney, Brian, additional, Shisler Marshall, Rebecca, additional, Mattioli, Flavia, additional, Maviş, İlknur, additional, Meinzer, Marcus, additional, Nilipour, Reza, additional, Noé, Enrique, additional, Paik, Nam-Jong, additional, Palmer, Rebecca, additional, Papathanasiou, Ilias, additional, Patrício, Brígida F, additional, Martins, Isabel Pavão, additional, Price, Cathy, additional, Jakovac, Tatjana Prizl, additional, Rochon, Elizabeth, additional, Rose, Miranda L, additional, Rosso, Charlotte, additional, Rubi-Fessen, Ilona, additional, Ruiter, Marina B, additional, Snell, Claerwen, additional, Stahl, Benjamin, additional, Szaflarski, Jerzy P, additional, Thomas, Shirley A, additional, van de Sandt-Koenderman, Mieke, additional, van der Meulen, Ineke, additional, Visch-Brink, Evy, additional, Worrall, Linda, additional, and Wright, Heather Harris, additional

Published
2022
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21. Gesturing by Speakers with Aphasia: How Does It Compare?

Author

Mol, Lisette, Krahmer, Emiel, and van de Sandt-Koenderman, Mieke

Abstract

Purpose: To study the independence of gesture and verbal language production. The authors assessed whether gesture can be semantically compensatory in cases of verbal language impairment and whether speakers with aphasia and control participants use similar depiction techniques in gesture. Method: The informativeness of gesture was assessed in 3 forced-choice studies, in which raters assessed the topic of the speaker's message in video clips of 13 speakers with moderate aphasia and 12 speakers with severe aphasia, who were performing a communication test (the Scenario Test). Both groups were compared and contrasted with 17 control participants, who either were or were not allowed to communicate verbally. In addition, the representation techniques used in gesture were analyzed. Results: Gestures produced by speakers with more severe aphasia were less informative than those by speakers with moderate aphasia, yet they were not necessarily uninformative. Speakers with more severe aphasia also tended to use fewer representation techniques (mostly relying on outlining gestures) in co-speech gesture than control participants, who were asked to use gesture instead of speech. It is important to note that limb apraxia may be a mediating factor here. Conclusions: These results suggest that in aphasia, gesture tends to degrade with verbal language. This may imply that the processes underlying verbal language and co-speech gesture production, although partly separate, are closely linked. (Contains 7 tables.)

Published
2013
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23. A 3-Year Evolution of Linguistic Disorders in Aphasia after Stroke

Author

El Hachioui, Hanane, van de Sandt-Koenderman, Mieke W. M. E., and Dippel, Diederik W. J.

Abstract

Aphasia recovery after stroke has been the subject of several studies, but in none the deficits on the various linguistic levels were examined, even though in the diagnosis and treatment of aphasia the emphasis lays more and more on these linguistic level disorders. In this observational prospective follow-up study, we explored whether it is meaningful to investigate the recovery of semantics, phonology, and syntax separately. Fifteen patients with aphasia poststroke were assessed at 3 and 10 days, 7 weeks, 4 and 7 months, and 3 years postonset with the ScreeLing, a linguistic level test, the Aphasia Severity Rating Scale (spontaneous speech) and the Token Test. Group results showed improvement for the overall ScreeLing (P less than 0.01) and its subparts semantics (P less than 0.01) and syntax (P less than 0.01) up to 7 weeks, just as the Token Test (P less than 0.01). Phonology improved up to 4 months (P less than 0.05) and spontaneous speech up to 7 months (P less than 0.05). The recovery pattern of the three linguistic levels did not follow a parallel course, with a great deal of variability in linguistic recovery curves between and within patients. These results suggest that it is meaningful to assess the recovery of the linguistic levels separately, starting from the acute stage poststroke.

Published
2011
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24. Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke

Author

Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, The RELEASE Collaborators, Williams, Louise R., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M T, Kambanaros, Maria, Kang, Eun K, Khedr, Eman M, Kong, Anthony P H, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Laska, Ann C, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca S, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Martins, Isabel P, Price, Cathy, Jakovac, Tatjana P, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather H, Brady, Marian C, and The RELEASE Collaborators

Abstract

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Methods: Data were collated by systematically identifying existing, eligible studies in any language ( ≥ 10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. Results: From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants’ median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ab

Published
2022

25. Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Background: Stroke rehabilitation interventions are routinely personalized to address individuals' needs, goals, and challenges based on evidence from aggregated randomized controlled trials (RCT) data and meta-syntheses. Individual participant data (IPD) meta-analyses may better inform the development of precision rehabilitation approaches, quantifying treatment responses while adjusting for confounders and reducing ecological bias. Aim: We explored associations between speech and language therapy (SLT) interventions frequency (days/week), intensity (h/week), and dosage (total SLT-hours) and language outcomes for different age, sex, aphasia severity, and chronicity subgroups by undertaking prespecified subgroup network meta-analyses of the RELEASE database. Methods: MEDLINE, EMBASE, and trial registrations were systematically searched (inception-Sept2015) for RCTs, including > 10 IPD on stroke-related aphasia. We extracted demographic, stroke, aphasia, SLT, and risk of bias data. Overall-language ability, auditory comprehension, and functional communication outcomes were standardized. A one-stage, random effects, network meta-analysis approach filtered IPD into a single optimal model, examining SLT regimen and language recovery from baseline to first post-intervention follow-up, adjusting for covariates identified a-priori. Data were dichotomized by age (<=/> 65 years), aphasia severity (mild-moderate/ moderate-severe based on language outcomes' median value), chronicity (<=/> 3 months), and sex subgroups. We reported estimates of means and 95% confidence intervals. Where relative variance was high (> 50%), results were reported for completeness. Results: 959 IPD (25 RCTs) were analyzed. For working-age participants, greatest language gains from baseline occurred alongside moderate to high-intensity SLT (functional communication 3-to-4 h/week; overall-language and comprehension > 9 h/week); older participants' greatest gains occurred alongside low-intensity SLT (<=

Published
2022

26. Dosage, Intensity, and Frequency of Language Therapy for Aphasia: A Systematic Review-Based, Individual Participant Data Network Meta-Analysis

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Branden-burg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, MaviS, ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaf-larski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Branden-burg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, MaviS, ilknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaf-larski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

BACKGROUND AND PURPOSE: Optimizing speech and language therapy (SLT) regimens for maximal aphasia recovery is a clinical research priority. We examined associations between SLT intensity (hours/week), dosage (total hours), frequency (days/week), duration (weeks), delivery (face to face, computer supported, individual tailoring, and home practice), content, and language outcomes for people with aphasia. METHODS: Databases including MEDLINE and Embase were searched (inception to September 2015). Published, unpublished, and emerging trials including SLT and >= 10 individual participant data on aphasia, language outcomes, and time post-onset were selected. Patient-level data on stroke, language, SLT, and trial risk of bias were independently extracted. Outcome measurement scores were standardized. A statistical inferencing, one-stage, random effects, network meta-analysis approach filtered individual participant data into an optimal model examining SLT regimen for overall language, auditory comprehension, naming, and functional communication pre-post intervention gains, adjusting for a priori-defined covariates (age, sex, time poststroke, and baseline aphasia severity), reporting estimates of mean change scores (95% CI). RESULTS: Data from 959 individual participant data (25 trials) were included. Greatest gains in overall language and comprehension were associated with >20 to 50 hours SLT dosage (18.37 [10.58-26.16] Western Aphasia Battery-Aphasia Quotient; 5.23 [1.51-8.95] Aachen Aphasia Test-Token Test). Greatest clinical overall language, functional communication, and comprehension gains were associated with 2 to 4 and 9+ SLT hours/week. Greatest clinical gains were associated with frequent SLT for overall language, functional communication (3-5+ days/week), and comprehension (4-5 days/week). Evidence of comprehension gains was absent for SLT <= 20 hours, <3 hours/week, and <= 3 days/week. Mixed receptive-expressive therapy, functionally tailored, with prescribed ho

Published
2022

27. Complex speech-language therapy interventions for stroke-related aphasia: The RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Harris Wright, Heather, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Harris Wright, Heather

Abstract

Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting: Participant data were collected in research and clinical settings. Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data sources and participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted. Review methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were used t

Published
2022

28. Complex speech-language therapy interventions for stroke-related aphasia:The RELEASE study incorporating a systematic review and individual participant data network meta-analysis

Author

Brady, Marian C., Ali, Myzoon, Berg, Kathryn Vanden, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Macwhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavi̧s, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, Berg, Kathryn Vanden, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M.T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak Hin, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Macwhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavi̧s, Ilknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patrício, Brígida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, Van Der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Background: People with language problems following stroke (aphasia) benefit from speech and language therapy. Optimising speech and language therapy for aphasia recovery is a research priority. Objectives: The objectives were to explore patterns and predictors of language and communication recovery, optimum speech and language therapy intervention provision, and whether or not effectiveness varies by participant subgroup or language domain. Design: This research comprised a systematic review, a meta-analysis and a network meta-analysis of individual participant data. Setting: Participant data were collected in research and clinical settings. Interventions: The intervention under investigation was speech and language therapy for aphasia after stroke. Main outcome measures: The main outcome measures were absolute changes in language scores from baseline on overall language ability, auditory comprehension, spoken language, reading comprehension, writing and functional communication. Data sources and participants: Electronic databases were systematically searched, including MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Linguistic and Language Behavior Abstracts and SpeechBITE (searched from inception to 2015). The results were screened for eligibility, and published and unpublished data sets (randomised controlled trials, non-randomised controlled trials, cohort studies, case series, registries) with at least 10 individual participant data reporting aphasia duration and severity were identified. Existing collaborators and primary researchers named in identified records were invited to contribute electronic data sets. Individual participant data in the public domain were extracted. Review methods: Data on demographics, speech and language therapy interventions, outcomes and quality criteria were independently extracted by two reviewers, or available as individual participant data data sets. Meta-analysis and network meta-analysis were use

Published
2022

29. sj-docx-1-wso-10.1177_17474930221097477 – Supplemental material for Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis

Author

Brady, Marian C, Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J, Williams, Louise R, Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A, Cranfill, Tamara B, Pietro-Bachmann, Marie di, Enderby, Pamela, Fillingham, Joanne, Lucia Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis MT, Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M, Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A, Charlotte Laska, Ann, Leemann, Béatrice, Leff, Alexander P, Lima, Roxele R, Lorenz, Antje, MacWhinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida, Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P, Thomas, Shirley A, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Harris Wright, Heather

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221097477 for Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis by Marian C Brady, Myzoon Ali, Kathryn VandenBerg, Linda J Williams, Louise R Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A Copland, Tamara B Cranfill, Marie di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis MT Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M Khedr, Anthony Pak-Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A Lambon Ralph, Ann Charlotte Laska, Béatrice Leemann, Alexander P Leff, Roxele R Lima, Antje Lorenz, Brian MacWhinney, Rebecca Shisler Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P Szaflarski, Shirley A Thomas, Mieke van de Sandt-Koenderman, Ineke van der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright and in International Journal of Stroke

Published
2022
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30. Inleiding

Author

Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, Hachioui, Hanane el, Visch-Brink, Evy, van de Sandt-Koenderman, Mieke, and Hachioui, Hanane el

Published
2010
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31. Inleiding

Author

van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, van Gelder-Houthuizen, Jane, Wiegers, Jiska, Wielaert, Sandra, and van de Sandt-Koenderman, Mieke

Published
2008
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33. Predictors of Poststroke Aphasia Recovery A Systematic Review-Informed Individual Participant Data Meta-Analysis

Author

Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Marshall, Rebecca Shisler, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Marshall, Rebecca Shisler, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, and Brady, Marian C.

Abstract

Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants' age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4-165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3-26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0-20.9], +6.1 correct on AAT Token Test [CI, 3.2-8.9]; +9.3 Boston Naming Test points [CI, 4.7-13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5-1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9-24.4]; +5.3 correct on AAT Token Test [CI, 1.7-8.8]; +11.1 Boston Naming Test points [CI, 5.7-16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7-1.4]) conferred the greatest absolute change-from-baseline across each language doma

Published
2021

34. RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Author

Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Whinney, Brian Mac, Marshall, Rebecca Shisler, Mattioli, Flavia, Mavis, İlknur, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van de Sandt-Koenderman, Mieke, Van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Subjects
Stroke, IPD, Meta-analysis, Complex intervention, Aphasia, Clinical Medicine, Medical and Health Sciences
Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)

Published
2020

35. Communicating simply, but not too simply: Reporting of participants and speech and language interventions for aphasia after stroke

Author

RELEASE Collaboration, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis Mt, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon-Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris, RELEASE Collaboration, Brady, Marian C., Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., di Pietro-Bachmann, Marie, Enderby, Pamela, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis Mt, Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon-Ralph, Matthew A., Laska, Ann Charlotte, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, MacWhinney, Brian, Marshall, Rebecca Shisler, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavão, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, and Wright, Heather Harris

Abstract

Purpose: Speech and language pathology (SLP) for aphasia is a complex intervention delivered to a heterogeneous population within diverse settings. Simplistic descriptions of participants and interventions in research hinder replication, interpretation of results, guideline and research developments through secondary data analyses. This study aimed to describe the availability of participant and intervention descriptors in existing aphasia research datasets. Method: We systematically identified aphasia research datasets containing ≥10 participants with information on time since stroke and language ability. We extracted participant and SLP intervention descriptions and considered the availability of data compared to historical and current reporting standards. We developed an extension to the Template for Intervention Description and Replication checklist to support meaningful classification and synthesis of the SLP interventions to support secondary data analysis. Result: Of 11, 314 identified records we screened 1131 full texts and received 75 dataset contributions. We extracted data from 99 additional public domain datasets. Participant age (97.1%) and sex (90.8%) were commonly available. Prior stroke (25.8%), living context (12.1%) and socio-economic status (2.3%) were rarely available. Therapy impairment target, frequency and duration were most commonly available but predominately described at group level. Home practice (46.3%) and tailoring (functional relevance 46.3%) were inconsistently available. Conclusion: Gaps in the availability of participant and intervention details were significant, hampering clinical implementation of evidence into practice and development of our field of research. Improvements in the quality and consistency of participant and intervention data reported in aphasia research are required to maximise clinical implementation, replication in research and the generation of insights from secondary data analysis. Systematic review registratio

Published
2020

37. ScreeLing

Author

Visch-Brink, Evy, primary, van de Sandt-Koenderman, Mieke, additional, and Hachioui, Hanane el, additional

Published
2010
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38. Scenario Test

Author

van der Meulen, Ineke, primary, van Gelder-Houthuizen, Jane, additional, Wiegers, Jiska, additional, Wielaert, Sandra, additional, and van de Sandt-Koenderman, Mieke, additional

Published
2008
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44. Now it is about me having to learn something....'Partners' experiences with a Dutch conversation partner training programme (PACT)

Author

Wielaert, Sandra M., Berns, Philine, van de Sandt-Koenderman, Mieke W.M., Dammers, Nina, Sage, Karen, and Rehabilitation Medicine

Subjects
experience, awareness, partners, aphasia
Abstract

Background; The increase in the number of reported conversation partner programmes for conversation partners of people with aphasia demonstrates increased awareness of partner needs and the positive effect of trained partners on the communicative abilities of the person with aphasia. Predominantly small scale studies describe the effectiveness of conversation partner training (CPT) and how partners perceive this training. The view of partners on this service commission remains largely unknown.\ud Aim; to explore the experiences of partners of people with aphasia with a conversation partner training programme when it was newly introduced into rehabilitation settings.\ud Methods & procedures; seventeen partners of people with aphasia were interviewed using a semi-structured format, about their experience with Partners of Aphasic clients Conversation Training (PACT). Transcribed interviews were analysed using qualitative content analysis.\ud Outcomes & results; four categories representative of the practical nature and individual tailoring of PACT were identified: engaging with PACT; learning from PACT; reflecting on behaviour and emotions and experiences with earlier speech and language therapy (SLT). Two themes were identified cutting across all categories: ‘the nature of communication is difficult to grasp’ and ‘balancing roles as partner, carer and client’.\ud Conclusions & Implications; Partners appreciated the training programme, once their initial lack of awareness of the interactive nature of communication had been addressed. SLTs need to be clear about the collaborative nature of conversations and what can be offered within the rehabilitation trajectory to address conversation alongside language training.

Published
2017

45. Who participates in aphasia research? An analysis of the REhabilitation and recovery of peopLE with Aphasia after StrokE (RELEASE) data set

Author

Ali, Myzoon, primary, Elders, Andrew, additional, Godwin, Jon, additional, Karachalia Sandri, Anastasia, additional, Williams, Linda J, additional, Williams, Louise R, additional, VandenBerg, Kathryn, additional, Abel, Stefanie, additional, Abo, Masahiro, additional, Becker, Frank, additional, Bowen, Audrey, additional, Brandenburg, Caitlin, additional, Breitenstein, Caterina, additional, Copland, David, additional, Cranfill, Tamara, additional, Di Pietro-Bachmann, Marie, additional, Enderby, Pam, additional, Fillingham, Joanne, additional, Galli, Federica, additional, Gandolfi, Marialuisa, additional, Glize, Bertrand, additional, Godecke, Erin, additional, Hilari, Katerina, additional, Hinckley, Jacqueline, additional, Horton, Simon, additional, Howard, David, additional, Jaecks, Petra, additional, Jefferies, Beth, additional, Jesus, Luis, additional, Kambanaros, Maria, additional, Khedr, Eman, additional, Kong, Anthony PH, additional, Kukkonen, Tarja, additional, Kyoung Kang, Eun, additional, Lambon Ralph, Matthew, additional, Laganaro, Marina, additional, Laska, Ann-Charlotte, additional, Leemann, Béatrice, additional, Leff, Alexander, additional, Lorenz, Antje, additional, MacWhinney, Brian, additional, Mattioli, Flavia, additional, Maviş, İlknur, additional, Meinzer, Marcus, additional, Noé Sebastián, Enrique, additional, Nilipour, Reza, additional, Paik, Nam-Jong, additional, Palmer, Rebecca, additional, Papathanasiou, Ilias, additional, Patricio, Brigida, additional, Pavão Martins, Isabel, additional, Price, Cathy, additional, Prizl Jakovac, Tatjana, additional, Rochon, Elizabeth, additional, Rose, Miranda L, additional, Rosso, Charlotte, additional, Ribeiro Lima, Roxele, additional, Rubi-Fessen, Ilona, additional, Ruiter, Marina, additional, Shisler Marshall, Rebecca, additional, Small, Steve, additional, Snell, Claerwen, additional, Stahl, Benjamin, additional, Szaflarski, Jerzy P, additional, Thomas, Shirley, additional, Van Der Meulen, Ineke, additional, Van De Sandt-Koenderman, Mieke, additional, Visch-Brink, Evy, additional, Worrall, Linda, additional, Wright, Heather Harris, additional, and Brady, Marian C, additional

Published
2018
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47. Prediction of everyday verbal communicative ability of aphasic stroke patients after inpatient rehabilitation

Author

Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, Other research (not in main researchprogram), Blom-Smink, Marieke R M A, van de Sandt-Koenderman, Mieke W M E, Kruitwagen, Cas L J J, El Hachioui, Hanane, Visch-Brink, Evy G., Ribbers, Gerard M., Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, Other research (not in main researchprogram), Blom-Smink, Marieke R M A, van de Sandt-Koenderman, Mieke W M E, Kruitwagen, Cas L J J, El Hachioui, Hanane, Visch-Brink, Evy G., and Ribbers, Gerard M.

Published
2017

48. Part of the message comes in gesture: how people with aphasia convey information in different gesture types as compared with information in their speech

Author

van Nispen, Karin, van de Sandt-Koenderman, Mieke, Sekine, Kazuki, Krahmer, Emiel, Rose, Miranda L., van Nispen, Karin, van de Sandt-Koenderman, Mieke, Sekine, Kazuki, Krahmer, Emiel, and Rose, Miranda L.

Abstract

Background: Studies have shown that the gestures produced by people with aphasia (PWA) can convey information useful for their communication. However, the exact significance of the contribution to message communication via gesture remains unclear. Furthermore, it remains unclear how different gesture types and representation techniques impact message conveyance.Aims: The present study aimed to investigate the contribution of gesture to PWA's communication. We specifically focussed on the degree to which different gesture types and representation techniques convey information absent in the speech of PWA.Methods & Procedure: We studied the gestures produced by 46 PWA and nine non-brain-damaged participants (NBDP) during semi-structured conversation. For each of the different types of gestures and representation techniques we identified whether these conveyed essential information, that is information that was absent in speech. Rather than looking at information that was either similar to information in speech or additional to information in speech, we focused on the essential gestures only.Outcomes & Results: For PWA, a fifth of their gestures were Essential. Despite individual differences between PWA, the majority produced more Essential gestures than NBDP, who produced limited amounts of Essential gestures. Essential information was mostly conveyed by specific gesture types: Pointing, Emblems and Iconic gesture. Within the group of iconic gestures, not only Handling and Enact but also Object and Shape gestures, were often Essential.Conclusions: Our findings suggest that a great proportion of gestures produced by most PWA convey information essential for understanding their communication. In their communication advice, speech language therapists could draw attention to specific gesture types to make sure that interlocutors pay more attention to these gestures when communicating with PWA.

Published
2017

49. Production and Comprehension of Pantomimes Used to Depict Objects

Author

van Nispen, Karin, van de Sandt-Koenderman, Mieke, Krahmer, Emiel, van Nispen, Karin, van de Sandt-Koenderman, Mieke, and Krahmer, Emiel

Abstract

Pantomime, gesture in absence of speech, has no conventional meaning. Nevertheless, individuals seem to be able to produce pantomimes and derive meaning from pantomimes. A number of studies has addressed the use of co-speech gesture, but little is known on pantomime. Therefore, the question of how people construct and understand pantomimes arises in gesture research. To determine how people use pantomimes, we asked participants to depict a set of objects using pantomimes only. We annotated what representation techniques people produced. Furthermore, using judgment tasks, we assessed the pantomimes’ comprehensibility. Analyses showed that similar techniques were used to depict objects across individuals. Objects with a default depiction method were better comprehended than objects for which there was no such default. More specifically, tools and objects depicted using a handling technique were better understood. The open-answer experiment showed low interpretation accuracy. Conversely, the forced-choice experiment showed ceiling effects. These results suggest that across individuals, similar strategies are deployed to produce pantomime, with the handling technique as the apparent preference. This might indicate that the production of pantomimes is based on mental representations which are intrinsically similar. Furthermore, pantomime conveys semantically rich, but ambiguous, information, and is much dependent on context. This pantomime database will be made available online. This can be used as a baseline with which we can compare clinical groups.

Published
2017

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