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3. Higher relative survival in breast cancer patients treated in certified and high-volume breast cancer centres – A population-based study in Belgium

Author

Leroy, Roos, Silversmit, Geert, Bourgeois, Jolyce, De Gendt, Cindy, Savoye, Isabelle, Verbeeck, Julie, Van Damme, Nancy, Stordeur, Sabine, Canon, Jean-Luc, Carly, Birgit, Cusumano, Pino G., de Azambuja, Evandro, De Visschere, Pieter, Decloedt, Jan, Desreux, Joëlle, Duhoux, Francois P., Taylor, Donatienne, van Dam, Peter, Vanhoutte, Ilse, Veldeman, Liv, and Wildiers, Hans

Published
2024
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4. Machine learning for ECG diagnosis and risk stratification of occlusion myocardial infarction

Author

Al-Zaiti, Salah S., Martin-Gill, Christian, Zègre-Hemsey, Jessica K., Bouzid, Zeineb, Faramand, Ziad, Alrawashdeh, Mohammad O., Gregg, Richard E., Helman, Stephanie, Riek, Nathan T., Kraevsky-Phillips, Karina, Clermont, Gilles, Akcakaya, Murat, Sereika, Susan M., Van Dam, Peter, Smith, Stephen W., Birnbaum, Yochai, Saba, Samir, Sejdic, Ervin, and Callaway, Clifton W.

Published
2023
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7. The Application of the Preoperative Image-Guided 3D Visualization Supported by Machine Learning to the Prediction of Organs Reconstruction During Pancreaticoduodenectomy via a Head-Mounted Displays

Author

Proniewska, Klaudia, Kolecki, Radek, Grochowska, Anna, Popiela, Tadeusz, Rogula, Tomasz, Malinowski, Krzysztof, Dołęga-Dołęgowski, Damian, Kenig, Jakub, Richter, Piotr, Dąbrowa, Julianna, Mortada, MHD Jafar, van Dam, Peter, Pregowska, Agnieszka, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, De Paolis, Lucio Tommaso, editor, Arpaia, Pasquale, editor, and Sacco, Marco, editor

Published
2023
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8. Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network

Author

Baldissera, Antonella, Benozzi, Elisabetta, Berger, Johannes, Bortul, Marina, Bussels, Barbara, Cagossi, Katia, Caruso, Francesco, Cedolini, Carla, Corsi, Fabio, Despierre, Evelyn, Despini, Luca, Duhoux, Francois P, Esgueva, Antonio J., Ferrari, Alberta, Fogazzi, Gianluca, Fortunato, Lucio, Fougo, José Luis, Generali, Daniele, Gennari, Alessandra, Ghilli, Matteo, Gianni, Lorenzo, Grossi, Simona, Huscher, Alessandra, Kozłowski, Leszek, Larsson, Karolina, Matos, Leonor, Montemezzi, Stefania, Musolino, Antonio, Negreiros, Ida, Orye, Guy, Polato, Romano, Prové, Annemie, Romanucci, Giovanna, Rossi, Lorenzo, Staelens, Gracienne, Tazzioli, Giovanni, Trunfio, Martino, Vassilieff, Maud, Verhoeven, Didier, Veronesi, Paolo, Zamagni, Claudio, Aristei, Cynthia, Tomatis, Mariano, Antonio Ponti, Marotti, Lorenza, Cardoso, Maria Joao, Cheung, Kwok Leung, Curigliano, Giuseppe, De Vries, Jakob, Santini, Donatella, Sardanelli, Francesco, Van Dam, Peter, and Rubio, Isabel Teresa

Published
2024
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11. Cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy in patients with advanced ovarian cancer (OVHIPEC-1): final survival analysis of a randomised, controlled, phase 3 trial

Author

Aronson, S Lot, Lopez-Yurda, Marta, Koole, Simone N, Schagen van Leeuwen, Jules H, Schreuder, Hendrik W R, Hermans, Ralph H M, de Hingh, Ignace H J T, van Gent, Mignon D J M, Arts, Henriëtte J G, van Ham, Maaike A P C, van Dam, Peter A, Vuylsteke, Peter, Aalbers, Arend G J, Verwaal, Victor J, Van de Vijver, Koen K, Aaronson, Neil K, Sonke, Gabe S, and van Driel, Willemien J

Published
2023
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12. Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study

Author

De Jaeghere, Emiel A., Tuyaerts, Sandra, Van Nuffel, An M. T., Belmans, Ann, Bogaerts, Kris, Baiden-Amissah, Regina, Lippens, Lien, Vuylsteke, Peter, Henry, Stéphanie, Trinh, Xuan Bich, van Dam, Peter A., Aspeslagh, Sandrine, De Caluwé, Alex, Naert, Eline, Lambrechts, Diether, Hendrix, An, De Wever, Olivier, Van de Vijver, Koen K., Amant, Frédéric, Vandecasteele, Katrien, and Denys, Hannelore G.

Published
2023
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13. The Application of the Preoperative Image-Guided 3D Visualization Supported by Machine Learning to the Prediction of Organs Reconstruction During Pancreaticoduodenectomy via a Head-Mounted Displays

Author

Proniewska, Klaudia, primary, Kolecki, Radek, additional, Grochowska, Anna, additional, Popiela, Tadeusz, additional, Rogula, Tomasz, additional, Malinowski, Krzysztof, additional, Dołęga-Dołęgowski, Damian, additional, Kenig, Jakub, additional, Richter, Piotr, additional, Dąbrowa, Julianna, additional, Mortada, MHD Jafar, additional, van Dam, Peter, additional, and Pregowska, Agnieszka, additional

Published
2023
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14. The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres

Author

Baldini, Valentina, Ballardini, Bettina, Berger, Johannes, Berlière, Martine, Bonetti, Andrea, Bortul, Marina, Bussels, Barbara, Cagossi, Katia, Epifanio Castiglione, Gaetano Antonio, Cedolini, Carla, Esgueva Colmenarejo, Antonio J., Corsi, Fabio, Cretella, Elisabetta, Fogazzi, Gianluca, Fortunato, Lucio, Fougo, José Luis, Generali, Daniele, Gouveia, Pedro F., Grossi, Simona, Huscher, Alessandra, Kaelides, Michalis, Kuhn, Elisabetta, Levy, Christelle, Massarut, Samuele, Meani, Francesco, Montemezzi, Stefania, Musolino, Antonio, Negreiros, Ida, Bagge, Roger Olofsson, Pagani, Gianmatteo, Peterko, Ana Car, Prové, Annemie, Roelstraete, Heidi, Roncella, Manuella, Saguatti, Gianni, Sarlos, Dimitri, Sgarella, Adele, Staelens, Gracienne, Taffurelli, Mario, Tazzioli, Giovanni, Tinterri, Corrado, Vassilieff, Maud, Verhoeven, Didier, van Dam, Peter, Tomatis, Mariano, Ponti, Antonio, Marotti, Lorenza, Aristei, Cynthia, Biganzoli, Laura, Cardoso, Maria J, Cheung, Kwok L, Curigliano, Giuseppe, De Vries, Jakob, Santini, Donatella, Sardanelli, Francesco, and Rubio, Isabel Teresa

Published
2022
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15. A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer (NEO-ORB)

Author

Mayer, Ingrid A, Prat, Aleix, Egle, Daniel, Blau, Sibel, Fidalgo, J Alejandro Pérez, Gnant, Michael, Fasching, Peter A, Colleoni, Marco, Wolff, Antonio C, Winer, Eric P, Singer, Christian F, Hurvitz, Sara, Estévez, Laura García, van Dam, Peter A, Kümmel, Sherko, Mundhenke, Christoph, Holmes, Frankie, Babbar, Naveen, Charbonnier, Laure, Diaz-Padilla, Ivan, Vogl, Florian D, Sellami, Dalila, and Arteaga, Carlos L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Breast Cancer, Clinical Research, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Breast Neoplasms, Cell Proliferation, Class I Phosphatidylinositol 3-Kinases, Female, High-Throughput Nucleotide Sequencing, Humans, Letrozole, Middle Aged, Mutation, Neoadjuvant Therapy, Receptor, ErbB-2, Receptors, Estrogen, Receptors, Progesterone, Signal Transduction, Thiazoles, Treatment Outcome, Receptor, erbB-2, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PURPOSE:Addition of alpelisib to fulvestrant significantly extended progression-free survival in PIK3CA-mutant, hormone receptor-positive (HR+) advanced/metastatic breast cancer in the phase III SOLAR-1 study. The combination of alpelisib and letrozole also had promising activity in phase I studies of HR+ advanced/metastatic breast cancer. NEO-ORB aimed to determine whether addition of alpelisib to letrozole could increase response rates in the neoadjuvant setting.Patients and Methods: Postmenopausal women with HR+, human epidermal growth factor receptor 2-negative, T1c-T3 breast cancer were assigned to the PIK3CA-wild-type or PIK3CA-mutant cohort according to their tumor PIK3CA status, and randomized (1:1) to 2.5 mg/day letrozole with 300 mg/day alpelisib or placebo for 24 weeks. Primary endpoints were objective response rate (ORR) and pathologic complete response (pCR) rate for both PIK3CA cohorts. RESULTS:In total, 257 patients were assigned to letrozole plus alpelisib (131 patients) or placebo (126 patients). Grade ≥3 adverse events (≥5% of patients) in the alpelisib arm were hyperglycemia (27%), rash (12%), and maculo-papular rash (8%). The primary objective was not met; ORR in the alpelisib versus placebo arm was 43% versus 45% and 63% versus 61% in the PIK3CA-mutant and wild-type cohorts, respectively. pCR rates were low in all groups. Decreases in Ki-67 were similar across treatment arms and cohorts. In PIK3CA-mutant tumors, alpelisib plus letrozole treatment induced a greater decrease in phosphorylated AKT versus placebo plus letrozole. CONCLUSIONS:In contrast to initial results in advanced/metastatic disease, addition of alpelisib to 24-week neoadjuvant letrozole treatment did not improve response in patients with HR+ early breast cancer.

Published
2019

16. Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station

Author

Urbaniak, Camilla, van Dam, Peter, Zaborin, Alexander, Zaborina, Olga, Gilbert, Jack A, Torok, Tamas, Wang, Clay CC, and Venkateswaran, Kasthuri

Subjects
Microbiology, Biological Sciences, Infectious Diseases, Genetics, Fusarium, International Space Station, fungi, genomics
Abstract

Two isolates of Fusarium oxysporum, ISS-F3 and ISS-F4, were cultured from the dining table on the International Space Station (ISS). Genomic analyses using EF-1α sequences, presence/absence of effector proteins, k-mer comparisons, and single nucleotide polymorphisms indicate that these two strains are genomically different from 65 known sequenced strains. Functional analysis revealed that ISS-F3/F4 had higher relative abundances of polyketide synthase domains than a non-plant-pathogenic soil isolate, used for biocontrol properties (Fo47), and a clinical isolate (FOSC-3a). Putative secondary metabolite analysis indicates that ISS-F3/F4 may produce yet-unreported polyketides and nonribosomal peptides. While genomic analysis showed that these ISS strains are unlikely to be plant pathogens, a virulence assay using an immunocompromised Caenorhabditis elegans model of fusariosis revealed that they were virulent and may represent opportunistic pathogens in animals, including humans. However, its effects on the health of immunocompromised humans warrant further study. IMPORTANCE This is the first study to isolate and characterize F. oxysporum isolates from a built environment, as well as one that has been exposed to space. The characterization and analysis of these two genomes may have important implications for the medical, agricultural, and food industries as well as for the health of the crew who coinhabit the ISS with these strains.

Published
2019

19. Uncertainty Quantification of the Effects of Segmentation Variability in ECGI

Author

Tate, Jess D., Good, Wilson W., Zemzemi, Nejib, Boonstra, Machteld, van Dam, Peter, Brooks, Dana H., Narayan, Akil, MacLeod, Rob S., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Ennis, Daniel B., editor, Perotti, Luigi E., editor, and Wang, Vicky Y., editor

Published
2021
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22. An open-label, single-arm, prospective, multi-center, tandem two-stage designed phase II study to evaluate the efficacy of fulvestrant in women with recurrent/metastatic estrogen receptor-positive gynecological malignancies (FUCHSia study)

Author

Trozzi, Rita, primary, Tuyaerts, Sandra, additional, Annibali, Daniela, additional, Herreros Pomares, Alejandro, additional, Boog, Lotte, additional, Van Dam, Peter, additional, Leunen, Karin, additional, Deroose, Christophe, additional, Trum, Hans, additional, and Amant, Frédéric, additional

Published
2024
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24. Saliency maps to enhance explainability of occlusion myocardial infarction classification among pre-hospital chest pain patients

Author

Riek, Nathan T., primary, Bouzid, Zeineb, additional, Gokhale, Tanmay, additional, Van Dam, Peter, additional, Kraevsky-Philips, Karina, additional, Helman, Stephanie, additional, Martin-Gill, Christian, additional, Callaway, Clifton W., additional, Saba, Samir, additional, Sejdic, Ervin, additional, Zegre-Hemsey, Jessica K., additional, Akcakaya, Murat, additional, and Al-Zaiti, Salah, additional

Published
2024
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26. Adaptive Cardiac Resynchronization Therapy Effect on Electrical Dyssynchrony (aCRT-ELSYNC): A randomized controlled trial

Author

Haq, Kazi T., Rogovoy, Nichole M., Thomas, Jason A., Hamilton, Christopher, Lutz, Katherine J., Wirth, Ashley, Bender, Aron B., German, David M., Przybylowicz, Ryle, van Dam, Peter, Dewland, Thomas A., Dalouk, Khidir, Stecker, Eric, Nazer, Babak, Jessel, Peter M., MacMurdy, Karen S., Zarraga, Ignatius Gerardo E., Beitinjaneh, Bassel, Henrikson, Charles A., Raitt, Merritt, Fuss, Cristina, Ferencik, Maros, and Tereshchenko, Larisa G.

Published
2021
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27. Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy in Patients With Advanced Ovarian Cancer (OVHIPEC-1): Final Survival Analysis of a Randomised, Controlled, Phase 3 Trial

Author

MS Gynaecologische Oncologie, Cancer, Aronson, S. Lot, Lopez-Yurda, Marta, Koole, Simone N., Schagen Van Leeuwen, Jules H., Schreuder, Hendrik W.R., Hermans, Ralph H.M., De Hingh, Ignace H.J.T., Van Gent, Mignon D.J.M., Arts, Henriëtte J.G., Van Ham, Maaike A.P.C., Van Dam, Peter A., Vuylsteke, Peter, Aalbers, Arend G.J., Verwaal, Victor J., Van De Vijver, Koen K., Aaronson, Neil K., Sonke, Gabe S., Van Driel, Willemien J., MS Gynaecologische Oncologie, Cancer, Aronson, S. Lot, Lopez-Yurda, Marta, Koole, Simone N., Schagen Van Leeuwen, Jules H., Schreuder, Hendrik W.R., Hermans, Ralph H.M., De Hingh, Ignace H.J.T., Van Gent, Mignon D.J.M., Arts, Henriëtte J.G., Van Ham, Maaike A.P.C., Van Dam, Peter A., Vuylsteke, Peter, Aalbers, Arend G.J., Verwaal, Victor J., Van De Vijver, Koen K., Aaronson, Neil K., Sonke, Gabe S., and Van Driel, Willemien J.

Published
2024

34. Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy in Patients With Advanced Ovarian Cancer (OVHIPEC-1): Final Survival Analysis of a Randomised, Controlled, Phase 3 Trial

Author

Aronson, S. Lot, primary, Lopez-Yurda, Marta, additional, Koole, Simone N., additional, Schagen van Leeuwen, Jules H., additional, Schreuder, Hendrik W.R., additional, Hermans, Ralph H.M., additional, de Hingh, Ignace H.J.T., additional, van Gent, Mignon D.J.M., additional, Arts, Henriëtte J.G., additional, van Ham, Maaike A.P.C., additional, van Dam, Peter A., additional, Vuylsteke, Peter, additional, Aalbers, Arend G.J., additional, Verwaal, Victor J., additional, Van de Vijver, Koen K., additional, Aaronson, Neil K., additional, Sonke, Gabe S., additional, and van Driel, Willemien J., additional

Published
2024
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41. Treatment and outcomes in breast cancer patients: a cross section study from the EUSOMA Breast Centre Network

Author

Aristei, Cynthia, primary, Tomatis, Mariano, additional, Ponti, Antonio, additional, Marotti, Lorenza, additional, Cardoso, Maria Joao, additional, Cheung, Kwok Leung, additional, Curigliano, Giuseppe, additional, De Vries, Jakob, additional, Santini, Donatella, additional, Sardanelli, Francesco, additional, Van Dam, Peter, additional, and Rubio, Isabel Teresa, additional

Published
2023
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42. Electrocardiographic temporo-spatial assessment of depolarization and repolarization changes after epicardial arrhythmogenic substrate ablation in Brugada syndrome

Author

Locati, Emanuela T, primary, Van Dam, Peter M, additional, Ciconte, Giuseppe, additional, Heilbron, Francesca, additional, Boonstra, Machteld, additional, Vicedomini, Gabriele, additional, Micaglio, Emanuele, additional, Ćalović, Žarko, additional, Anastasia, Luigi, additional, Santinelli, Vincenzo, additional, and Pappone, Carlo, additional

Published
2023
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44. Multidisciplinary molecular tumour board: a tool to improve clinical practice and selection accrual for clinical trials in patients with cancer

Author

Rolfo, Christian, Manca, Paolo, Salgado, Roberto, Van Dam, Peter, Dendooven, Amelie, Ferri Gandia, Jose, Rutten, Annemie, Lybaert, Willem, Vermeij, Joanna, Gevaert, Thomas, Weyn, Christine, Lefebure, Anneke, Metsu, Sofie, Van Laere, Steven, Peeters, Marc, Pauwels, Patrick, and Machado Coelho, Andreia

Published
2018
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46. Quantitative localization of premature ventricular contractions using myocardial activation ECGI from the standard 12-lead electrocardiogram

Author

van Dam, Peter M, Tung, Roderick, Shivkumar, Kalyanam, and Laks, Michael

Subjects
Clinical Research, Cardiovascular, Biomedical Imaging, Heart Disease, Adolescent, Adult, Algorithms, Body Surface Potential Mapping, Cardiac-Gated Imaging Techniques, Computer Simulation, Diagnosis, Computer-Assisted, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Models, Cardiovascular, Reproducibility of Results, Sensitivity and Specificity, Ventricular Premature Complexes, Myocardial activation ECGI, lead ECG, PVC localization, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

BackgroundThe precise localization of the site of origin of a premature ventricular contractions (PVC) prior to ablation would facilitate the planning and execution of the electrophysiological procedure. Current electrocardiographic imaging (ECGI) techniques require body surface maps, a costly and complex procedure, that requires as many as 256 leads to localize the PVC origin. We developed and tested a novel myocardial activation based ECGI technique utilizing the readily available 12-lead ECG to localize the PVC origin.MethodsThe major components of the 12-lead ECGI method are: the source model, proximity effect and spatial orientation, volume conductor, and patient specific model of the heart, lungs, and thorax as derived from magnetic resonance imaging (MRI). For the PVC origin localization, the fastest route algorithm is used on patient specific models created by newly developed morphing software. PVC localization by the 12-lead ECGI was correlated to the site of successful ablation.ResultsSeven patients that underwent electrophysiological mapping and ablation of PVCs were studied. All patients (7/7) had accurate prediction of the PVC origin. However in two patients, no specific MRI was used for localization that resulted in an incorrect switch between the RV free wall and septum of the RVOT. With patient-specific models, these latter two cases would likely be localized correctly.ConclusionsThis feasibility study of a novel myocardial activation-based ECGI using only the standard 12-lead ECG shows promise to localize the origin of PVC. This ECGI method yields activation estimates of isochrones on both ventricles from which the PVC origin location is derived. This method has the capability to localize the PVC from any part of the ventricular endocardium, intra-myocardium or epicardium.

Published
2013

48. The immune microenvironment characterisation and dynamics in hormone receptor–positive breast cancer before and after neoadjuvant endocrine therapy

Author

Oner, Gizem, primary, Broeckx, Glenn, additional, Van Berckelaer, Christophe, additional, Zwaenepoel, Karen, additional, Altintas, Sevilay, additional, Canturk, Zafer, additional, Tjalma, Wiebren, additional, Berneman, Zwi, additional, Peeters, Marc, additional, Pauwels, Patrick, additional, and van Dam, Peter A., additional

Published
2023
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