38 results on '"Van Dam, P. S."'
Search Results
2. Childhood maltreatment, adult attachment and psychotic symptomatology: a study in patients, siblings and controls
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van Dam, D. S., Korver-Nieberg, N., Velthorst, E., Meijer, C. J., de Haan, L., and For Genetic Risk and Outcome in Psychosis (GROUP)
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- 2014
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3. Cognitief functioneren van prostaatkankerpatiënten die hormonale therapie ondergaan
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Schilder, C. M. T., van Dijk, S. C., Meinhardt, W., van Dam, F. S. A. M, and Schagen, S. B.
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- 2011
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4. Mineralocorticoid status and endocrine dysfunction in severe hemochromatosis
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Hempenius, L. M. C., Van Dam, P. S., Marx, J. J. M., and Koppeschaar, H. P. F.
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- 1999
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5. A study of the reliability, validity and responsiveness of the HIV Overview of Problems Evaluation System (HOPES) in assessing the quality of life of patients with AIDS and symptomatic HIV infection
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De Boer, J. B., Sprangers, M. A. G., Aaronson, N. K., Lange, J. M. A., and van Dam, F. S. A. M.
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- 1996
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6. Health-Related Quality-of-Life Evaluation in HIV-Infected Patients: A Review of the Literature
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de Boer, Josien B., van Dam, Frits S. A. M., and Sprangers, Mirjam A. G.
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- 1995
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7. Prevalence of Delayed Gastric Emptying in Diabetic Patients and Relationship to Dyspeptic Symptoms: A prospective study in unselected diabetic patients
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Samsom, M., Vermeijden, J. R., Smout, A. J.P.M., van Doorn, E., Roelofs, J., van Dam, P. S., Martens, E. P., Eelkman-Rooda, S. J., and van Berge-Henegouwen, G. P.
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- 2003
8. Glutathione and α-lipoate in diabetic rats: nerve function, blood flow and oxidative state
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van Dam, P. S., van Asbeck, B. S., van Oirschot, J. F. L. M., Biessels, G. J., Hamers, F. P. T., and Marx, J. J. M.
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- 2001
9. Growth Hormone (GH) Treatment Decreases Postprandial Remnant-Like Particle Cholesterol Concentration and Improves Endothelial Function in Adult-Onset GH Deficiency*
- Author
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Twickler, T B, Wilmink, H W, Schreuder, P C. N. J, Cabezas, M Castro, van Dam, P S, Koppeschaar, H P. F, Erkelens, D W, and Dallinga-Thie, G M
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- 2000
10. Quality-of-Life Assessment in Cancer
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van Dam, F. S. A. M., Sternswärd, J., and Jönsson, B.
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- 1993
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11. Effects of insulin treatment on endoneurial and systemic oxidative stress in relation to nerve conduction in streptozotocin-diabetic rats
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VAN DAM, P. S., BRAVENBOER, B., VAN ASBECK, B. S., VAN OIRSCHOT, J. F. L. M., MARX, J. J. M., and GISPEN, W. H.
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- 1996
12. EFFECT OF HIGH GLUCOSE LEVELS ON Na+,K+-ATPase AND LIPID PEROXIDATION IN CULTURED DRG-CELLS
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Dijkstra, S., Biessels, G., van Dam, P. S., and Bär, P. R.
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- 1996
13. A narrative review of frailty assessment in older patients at the emergency department
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van Dam, Carmen S., Hoogendijk, Emiel O., Mooijaart, Simon P., Smulders, Yvo M., de Vet, Riekie C.W., Lucke, Jacinta A., Blomaard, Laura C., Otten, René H.J., Muller, Majon, Nanayakkara, Prabath W.B., Trappenburg, Marijke C., and Peters, Mike J.L.
- Abstract
Supplemental Digital Content is available in the text.Optimizing emergency care for the aging population is an important future challenge, as the proportion of older patients at the emergency department (ED) rapidly increases. Older patients, particularly those who are frail, have a high risk of adverse outcomes after an ED visit, such as functional decline, institutionalization, and death. The ED can have a key position in identifying frail older patients who benefit most from comprehensive geriatric care [including delirium preventive measures, early evaluation of after-discharge care, and a comprehensive geriatric assessment (CGA)]. However, performing extensive frailty assessment is not suitable at the ED. Therefore, quick and easy-to-use instruments are needed to identify older patients at risk for adverse outcomes. This narrative review outlines the importance and complexity of frailty assessment at the ED. It aligns the available screening instruments, including clinical judgment as frailty assessment, and summarizes arguments for and against frailty assessment at the ED.
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- 2021
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14. Childhood abuse and neglect in relation to the presence and persistence of psychotic and depressive symptomatology
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van Dam, D. S. and van Dam, D. S.
- Abstract
Background. The association between childhood trauma and psychotic and depressive symptomatology is well established. However, less is known about the specificity and course of these symptoms in relation to childhood trauma. Method. In a large sample (n=2765) of patients with psychosis (n=1119), their siblings (n=1057) and controls (n=589), multivariate (mixed-effects) regression analyses with multiple outcomes were performed to examine the association between childhood trauma and psychotic and depressive symptomatology over a 3-year period. Results. A dose-response relationship was found between childhood trauma and psychosis. Abuse was more strongly associated with positive symptoms than with negative symptoms whereas the strength of the associations between neglect and positive and negative symptoms was comparable. In patients, similar associations between childhood trauma and psychotic or depressive symptoms were found, and in siblings and controls, stronger associations were found between trauma and depressive symptomatology. Childhood trauma was not related to a differential course of symptoms over a 3-year time period. Conclusions. In congruence with earlier work, our findings suggest that childhood trauma, and abuse in particular, is associated with (subthreshold) psychosis. However, childhood trauma does not seem to be associated with a differential course of symptoms, nor does it uniquely heighten the chance of developing (subthreshold) psychotic symptomatology. Our results indicate that trauma may instead contribute to a shared vulnerability for psychotic and depressive symptoms.
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- 2015
15. Leven met cytostatica
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Linssen, A. C. G., Van Dam, F. S. A. M., Engelsman, E., Van Benthem, J., and Hanewald, G. J. F. P.
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- 1979
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16. Importance of baseline prognostic factors with increasing time since initiation of highly active antiretroviral therapy: collaborative analysis of cohorts of HIV-1-infected patients
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Sterne, Jonathan A. C., May, Margaret, Sabin, Caroline, Phillips, Andrew, Costagliola, Dominique, Chêne, Geneviève, Justice, Amy C., De Wolf, Frank, Hogg, Robert, Battegay, Manuel, Monforte, Antonella D'Arminio, Gerdtkenheuer, Fa, Staszewski, Schlomo, Gill, John, Egger, Matthias, Casabona, Jordi, Dabis, Francxois, Kitahata, Mari, Leport, Catherine, Lundgren, Jens, Reiss, Peter, Saag, Michael, Weller, Ian, Beckthold, Brenda, Yip, Benita, Dauer, Brenda, Fusco, Jenifer, Lanoy, Emilie, Rickenbach, Martin, Lavignolle, Valerie, Van Sighem, Ard, Pereira, Edwige, Pezzotti, Patrizio, Schmeisser, Norbert, Billaud, E., Boué, F., Costagliola, D., Duval, X., Duvivier, C., Enel, P., Fournier, S., Gasnault, J., Gaud, C., Gilquin, J., Grabar, S., Khuong, M. A., Lang, J. M., Mary Krause, M., Matheron, S., Meyohas, M. C., Pialoux, G., Poizot Martin, I., Pradier, C., Rouveix, E., Salmon Ceron, D., Sobel, A., Tattevin, P., Tissot Dupont, H., Yasdanpanah, Y., Aronica, E, Tirard Fleury, V., Tortay, I., Abgrall, S., Guiguet, M., Lanoy, E., Leneman, H., Lièvre, L., Potard, V., Saidi, S., Vildé, J. L., Leport, C., Yeni, P., Bouvet, E., Gaudebout, C., Crickx, B., Picard Dahan, C., Weiss, L., Tisne Dessus, D., Sicard, D., Salmon, D., Auperin, I., Viard, J. P., Roudière, L., Fior, R., Delfraissy, J. F., Goujard, C., Lesprit, P. h., Jung, C., Meynard, J. L., Picard, O., Desplanque, N., Cadranel, J., Mayaud, C., Rozenbaum, W., Bricaire, F., Katlama, C., Herson, S., Simon, A., Decazes, J. M., Molina, J. M., Clauvel, J. P., Gerard, L., Sellier, P., Diemer, M., Dupont, C., Berthé, H., Saïag, P., Mortier, E., Chandemerle, C., De Truchis, P., Bentata, M., Honoré, P., Tassi, S., Jeantils, V., Mechali, D., Taverne, B., Laurichesse, H., Gourdon, F., Lucht, F., Fresard, A., Faller, J. P., Eglinger, P., Bazin, C., Verdon, R., Peyramond, D., Boibieux, A., Touraine, J. L., Livrozet, J. M., Trepo, C., Cotte, L., Ravaux, I., Delmont, J. P., Moreau, J., Gastaut, J. A., Soubeyrand, J., Retornaz, F., Blanc, P. A., Allegre, T., Galinier, A., Ruiz, J. M., Lepeu, G., Granet Brunello, P., Pelissier, L., Esterni, J. P., Nezri, M., Cohen Valensi, R., Laffeuillade, A., Chadapaud, S., Reynes, J., May, T., Rabaud, C., Raffi, F., Pugliese, P., Michelet, C., Arvieux, C., Caron, F., Borsa Lebas, F., Rey, D., Fraisse, P., Massip, P., Cuzin, L., Arlet Suau, E., Thiercelin Legrand, M. F., Sobesky, M., Pradinaud, R., Contant, M., Montroni, M., Scalise, G., Braschi, M. C., Riva, A., Tirelli, U., Cinelli, R., Pastore, G., Ladisa, N., Minafra, G., Suter, F., Arici, C., Pristera, R., Chiodo, F., Colangeli, V., Fiorini, C., Coronado, O., Carosi, G., Cadeo, G. P., Torti, C., Minardi, C., Bertelli, D., Rizzardini, G., Melzi, S., Manconi, P. E., Piano, P., Cosco, L., Scerbo, A., Vecchiet, J., D'Alessandro, M., Santoro, D., Pusterla, L., Carnevale, G., Citterio, P., Viganò, P., Mena, M., Ghinelli, F., Sighinolfi, L., Leoncini, F., Mazzotta, F., Pozzi, M., Lo Caputo, S., Vullo, Vincenzo, Lichtner, Miriam, Angarano, G., Grisorio, B., Saracino, A., Ferrara, S., Grima, P., Tundo, P., Pagano, G., Cassola, G., Alessandrini, A., Piscopo, R., Toti, M., Chigiotti, S., Soscia, F., Tacconi, L., Orani, A., Perini, P., Scasso, A., Vincenti, A., Chiodera, F., Castelli, P., Scalzini, A., Palvarini, L., Moroni, M., Lazzarin, A., Cargnel, A., Vigevani, G. M., Caggese, L., d'Arminio Monforte, A., Repetto, D., Galli, A., Merli, S., Pastecchia, C., Moioli, M. C., Esposito, R., Mussini, C., Abrescia, N., Chirianni, A., Izzo, C. M., Piazza, M., De Marco, M., Viglietti, R., Manzillo, E., Nappa, S., Antonucci, G., Iacomi, F., Narciso, P., Zaccarelli, M., Colomba, A., Abbadessa, V., Prestileo, T., Mancuso, S., Ferrari, C., Pizzaferri, P., Filice, G., Minoli, L., Bruno, R., Novati, S., Baldelli, F., Tinca, M., Petrelli, E., Cioppi, A., Alberici, F., Ruggieri, A., Menichetti, F., Martinelli, C., De Stefano, C., La Gala, A., Ballardini, G., Rizzo, E., Magnani, G., Ursitti, M. A., Arlotti, M., Ortolani, P., Cauda, R., Dianzani, F., Ippolito, G., Antinori, A., D'Elia, S., Petrosillo, N., De Luca, A., Bacarelli, A., Acinapura, R., De Longis, P., Brandi, A., Trotta, M. P., Noto, P., Capobianchi, M. R., Carletti, F., Girardi, E., Pezzotti, P., Rezza, G., Mura, M. S., Mannazzu, M., Caramello, P., Di Perri, G., Soranzo, M. L., Orofino, G. C., Arnaudo, I., Bonasso, M., Grossi, P. A., Basilico, C., Poggio, A., Bottari, G., Raise, E., Ebo, F., De Lalla, F., Tositti, G., Resta, F., Loso, K., Cozzi Lepri, A., Johnson, A. M., Mercey, D., Phillips, A., Johnson, M. A., Mocroft, A., Murphy, M., Weber, J., Scullard, G., Fisher, M., Battegay, M., Bernasconi, E., Böni, J., Bucher, H., Bürgisser, P. h., Cattacin, S., Cavassini, M., Dubs, R., Egger, M., Elzi, L., Erb, P., Fantelli, K., Fischer, M., Flepp, M., Fontana, A., Francioli, P., Hirschel, B., Soravia Dunand, V., Furrer, H., Gorgievski, M., Günthard, H., Kaiser, L., Kind, C., Klimkait, T. h., Lauper, U., Ledergerber, B., Opravil, M., Paccaud, F., Pantaleo, G., Perrin, L., Piffaretti, J. C., Rickenbach, M., Rudin, C., Schmid, P., Schüpbach, J., Speck, R., Telenti, A., Trkola, A., Vernazza, P., Buy, E., Bronsveld, W., Hillebrand Haverkort, M. E., Reiss, P., Back, N. K. T., Bakker, M. E. G., Berkhout, B., Jurriaans, S., Cuijpers, T. h., Rietra, P. J. G. M., Roozendaal, K. J., Pauw, W., Van Zanten, A. P., Smits, P. H. M., Von Blomberg, B. M. E., Savelkoul, P., Danner, S. A., Van Agtmael, M. A., Claessen, F. A. P., Perenboom, R. M., Rijkeboer, A., Van Vonderen, M., Kuijpers, T. W., Pajkrt, D., Scherpbier, H. J., Prins, J. M., Bos, J. C., Eeftinck Schattenkerk, J. K. M., Geerlings, S. E., Godfried, M. H., Lange, J. M. A., Van Leth, F. C., Lowe, S. H., Van Der Meer, J. T. M., Nellen, F. J. B., Pogány, K., Van Der Poll, T., Ruys, T. h. A., Sankatsing, S., Steingrover, R., Van Twillert, G., Van Der Valk, M., Van Vonderen, M. G. A., Vrouenraets, S. M. E., Van Vugt, M., Wit, F. W. M. N., Veenstra, J., Van Eeden, A., Veen, J. H., Van Dam, P. S., Roos, J. C., Brinkman, K., Frissen, P. H. J., Weigel, H. M., Mulder, J. W., Van Gorp, E. C. M., Meenhorst, P. L., Mairuhu, A. T. A., Richter, C., Van Der Berg, J., Van Leusen, R., Swanink, C. M. A., Vriesendorp, R., Jeurissen, F. J. F., Franck, P. F. H., Lampe, A. S., Kauffmann, R. H., Koger, E. L. W., Bravenboer, B., Ten Napel, C. H. H., Kootstra, G. J., Schirm, J., Bennw, C. A., Sprenger, H. G., Miesen, W. M. A. J., Doedens, R., Scholvinck, E. H., Ten Kate, R. W., Van Houte, D. P. F., Polee, M., Kroes, A. C. M., Claas, H. C. J., Kroon, F. P., Van Den, Broek, Van Dissel, J. T., Schippers, E. F., Bruggeman, C. A. M. V. A., Goossens, V. J., Schreij, G., Van De Geest, S., Verbon, A., Galama, J. M. D., Melchers, W. J. G., Poort, Y. A. G., Koopmans, P. P., Keuter, M., Post, F., Van Der Ven, A. J. A. M., Doornum, G. J. J., Niesters, M. G., Osterhaus, A. D. M. E., Schutten, M., Driessen, G., De Groot, R., Hartwig, N., Van Der Ende, M. E., Gyssens, I. C., Van Der Feltz, M., Den Hollander, J. G., De Marie, S., L. Nouwen, J., Rijnders, B. J. A., De Vries, T. E. M. S., Juttmann, J. R., Van De Heul, C., Van Kasteren, M. E. E., Boucher, C. A. B., Schuurman, R., Geelen, S. P. M., Wolfs, T. F. W., Schneider, M. M. E., Bonten, M. J. M., Borleffs, J. C. C., Ellerbroek, P. M., Hoepelman, I. M., Jaspers, C. A. J. J., Schouten, I., Schurink, C. A. M., Blok, W. L., Tanis, A. A., Groeneveld, P. H. P., Jansen, C. L., Hendriks, R., Veenendaal, D., Storm, H., Weel, J., Van Zeijl, J. H., Buiting, A. G. M., Swaans, C. A. M., Boel, E., Jansz, A. F., Losso, M., Duran, A., Vetter, N., Karpov, I., Vassilenko, A., Clumeck, N., Dewit, S., Poll, B., Colebunders, R., Machala, L., Rozsypal, H., Sedlacek, D., Gerstoft, J., Katzenstein, T., Hansen, A. B. E., Skinhøj, P., Nielsen, J., Lundgren, J., Benfield, T., Kirk, O., Pedersen, C., Zilmer, K., Girard, P. M., Saint Marc, T., Vanhems, P., Dabis, F., Dietrich, M., Manegold, C., Van Lunzen, J., Stellbrink, H. J., Staszewski, S., Bickel, M., Goebel, F. D., Fätkenheuer, G., Rockstroh, J., Schmidt, R., Kosmidis, J., Gargalianos, P., Sambatakou, H., Perdios, J., Panos, G., Filandras, A., Karabatsaki, E., Banhegyi, D., Mulcahy, F., Yust, I., Turner, D., Burke, M., Pollack, S., Hassoun, G., Sthoeger, Z., Maayan, S., Borghi, R., Cotugno, A. D., Gabbuti, A., Chiesi, A., Montesarchio, E., Finazzi, R., D'Arminio Monforte, A., Viksna, L., Chaplinskas, S., Hemmer, R., Staub, T., Bruun, J., Maeland, A., Ormaasen, V., Knysz, B., Gasiorowski, J., Horban, A., Prokopowicz, D., Wiercinska Drapalo, A., Boron Kaczmarska, A., Pynka, M., Beniowski, M., Mularska, E., Trocha, H., Antunes, F., Valadas, E., Mansinho, K., Matez, F., Duiculescu, D., Babes, Victor, Streinu Cercel, A., Vinogradova, E., Rakhmanova, A., Jevtovic, D., Mokráš, M., Staneková, D., González Lahoz, J., Sánchez Conde, M., García Benayas, T., Martin Carbonero, L., Soriano, V., Clotet, B., Jou, A., Conejero, J., Tural, C., Gatell, J. M., Miró, J. M., Blaxhult, A., Karlsson, A., Pehrson, P., Weber, R., Kravchenko, E., Chentsova, N., Barton, S., Brettle, R., Loveday, C., Antunes, Francisco, Blaxhult, Anders, Clumeck, Nathan, Gatell, Jose, Horban, Andrzej, Johnson, Anne, Katlama, Christine, Ledergerber, Bruno, Loveday, Clive, Vella, Stefano, Gjørup, I., Friis Moeller, N., Bannister, W., Mollerup, D., Podlevkareva, D., Holkmann Olsen, C., Kjær, J., Raffanti, Stephen, Dieterch, Douglas, Becker, Stephen, Scarsella, Anthony, Fusco, Gregory, Most, Bernard, Balu, Rukmini, Rana, Rashida, Beckerman, Robin, Ising, Theodore, Fusco, Jennifer, Irek, Renae, Johnson, Bernadette, Hirani, Ashwin, Edwinjesus, De, Pierone, Gerald, Lackey, Philip, Irek, Chip, Johnson, Alison, Burdick, John, Leon, Saul, Arch, Joseph, Helm, Eilke B., Carlebach, Amina, Axelller, Mu, Haberl, Annette, Nisius, Gabi, Lennemann, Tessa, Rottmann, Carsten, Wolf, Timo, Stephan, Christoph, Bickel, Markus, Manfredsch, Mo, Gute, Peter, Locher, Leo, Lutz, Thomas, Klauke, Stephan, Knecht, Gabi, Doerr, Hans W., Stu, Martinrmer, Von Hentig, Nils, Jennings, Beverly, Beylot, J., Chêne, G., Dupon, M., Longy Boursier, M., Pellegrin, J. L., Ragnaud, J. M., Salamon, R., Thiébaut, R., Lewden, C., Lawson Ayayi, S., Mercié, P., Moreau, J. F., Morlat, P., Bernard, N., Lacoste, D., Malvy, D., Neau, D., Blaizeau, M. J., Decoin, M., Delveaux, S., Hannapier, C., Labarrère, S., Lavignolle Aurillac, V., Uwamaliya Nziyumvira, B., Palmer, G., Touchard, D., Balestre, E., Alioum, A., Jacqmin Gadda, H., Bonarek, M., Bonnet, F., Coadou, B., Gellie, P., Nouts, C., Bocquentin, F., Dutronc, H., Lafarie, S., Aslan, A., Pistonne, T., Thibaut, P., Vatan, R., Chambon, D., De La Taille, C., Cazorla, C., Ocho, A., Viallard, J. F., Caubet, O., Cipriano, C., Lazaro, E., Couzigou, P., Castera, L., Fleury, H., Lafon, M. E., Masquelier, B., Pellegrin, I., Breilh, D., Blanco, P., Loste, P., Caunègre, L., Bonnal, F., Farbos, S., Ferrand, M., Ceccaldi, J., Tchamgoué, S., De Witte, S., Alexander, Chris, Barrios, Rolando, Braitstein, Paula, Brumme, Zabrina, Chan, Keith, Cote, Helen, Gataric, Nada, Geller, Josie, Guillemi, Silvia, Richard Harrigan, P., Harris, Marrianne, Joy, Ruth, Levy, Adrian, Montaner, Julio, Montessori, Val, Palepu, Anita, Phillips, Elizabeth, Phillips, Peter, Press, Natasha, Tyndall, Mark, Wood, Evan, Bhagani, S., Byrne, P., Carroll, A., Cuthbertson, Z., Dunleavy, A., Geretti, A. M., Heelan, B., Johnson, M., Kinloch de Loes, S., Lipman, M., Madge, S., Marshall, N., Nair, D., Nebbia, G., Prinz, B., Swaden, L., Tyrer, M., Youle, M., Chaloner, C., Grabowska, H., Holloway, J., Puradiredja, J., Ransom, D., Tsintas, R., Bansi, L., Fox, Z., Harris, E., Hill, T., Lampe, F., Lodwick, R., Reekie, J., Sabin, C., Smith, C., Amoah, E., Booth, C., Clewley, G., Garcia Diaz, A., Gregory, B., Labbett, W., Tahami, F., Thomas, M., Read, Ron, Fatkenheuer, G., Schmeisser, N., Voigt, K., Wasmuth, J. C., Wohrmann, A., Infectious diseases, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Medical Microbiology and Infection Prevention, Paediatric Infectious Diseases / Rheumatology / Immunology, Landsteiner Laboratory, ARD - Amsterdam Reproduction and Development, Graduate School, Cardiology, APH - Global Health, APH - Quality of Care, AII - Infectious diseases, AII - Inflammatory diseases, and Global Health
- Subjects
Adult ,medicine.medical_specialty ,AIDS ,CD4 counts ,Highly active antiretroviral therapy ,HIV ,Prognosis ,Substance abuse (intravenous) ,Adolescent ,Anti-HIV Agents ,Antiretroviral Therapy, Highly Active ,CD4 Lymphocyte Count ,Europe ,HIV Infections ,HIV-1 ,Humans ,Middle Aged ,North America ,Risk Factors ,Substance Abuse, Intravenous ,Survival Analysis ,Pharmacology (medical) ,Infectious Diseases ,Cost effectiveness ,Antiretroviral Therapy ,Article ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,medicine ,Highly Active ,Survival analysis ,Immunodeficiency ,business.industry ,Transmission (medicine) ,Hazard ratio ,Substance Abuse ,medicine.disease ,Confidence interval ,Physical therapy ,Intravenous ,business ,Cohort study - Abstract
Background: The extent to which the prognosis for AIDS and death of patients initiating highly active antiretroviral therapy (HAART) continues to be affected by their characteristics at the time of initiation (baseline) is unclear. Methods: We analyzed data on 20,379 treatment-naive HIV-1- infected adults who started HAART in 1 of 12 cohort studies in Europe and North America (61,798 person-years of follow-up, 1844 AIDS events, and 1005 deaths). Results: Although baseline CD4 cell count became less prognostic with time, individuals with a baseline CD4 count 350 cells/μL (hazard ratio for AIDS = 2.3, 95% confidence interval [CI]: 1.0 to 2.3; mortality hazard ratio = 2.5, 95% CI: 1.2 to 5.5, 4 to 6 years after starting HAART). Rates of AIDS were persistently higher in individuals who had experienced an AIDS event before starting HAART. Individuals with presumed transmission by means of injection drug use experienced substantially higher rates of AIDS and death than other individuals throughout follow-up (AIDS hazard ratio = 1.6, 95% CI: 0.8 to 3.0; mortality hazard ratio = 3.5, 95% CI: 2.2 to 5.5, 4 to 6 years after starting HAART). Conclusions: Compared with other patient groups, injection drug users and patients with advanced immunodeficiency at baseline experience substantially increased rates of AIDS and death up to 6 years after starting HAART.
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- 2007
17. Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA
- Author
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Kraaij, Tineke, Kamerling, Sylvia W.A., van Dam, Laura S., Bakker, Jaap A., Bajema, Ingeborg M., Page, Theresa, Brunini, Francesca, Pusey, Charles D., Toes, Rene E.M., Scherer, Hans U., Rabelink, Ton J., van Kooten, Cees, and Teng, Y.K. Onno
- Abstract
Neutrophil extracellular traps (NETs) are auto-antigenic strands of extracellular DNA covered with myeloperoxidase (MPO) and proteinase3 (PR3) that can be a source for the formation of anti-neutrophil cytoplasmic autoantibodies (ANCAs). The presence of NETs was recently demonstrated in renal tissue of patients with ANCA-associated vasculitis (AAV). NET formation was enhanced in AAV, suggesting that MPO-ANCA could trigger NET formation, supporting a vicious circle placing NETs in the center of AAV pathogenesis. Here we investigated NET formation in 99 patients with AAV by a novel highly sensitive and automated assay. There was a significant excess of ex vivoNET formation in both MPO-ANCA– and PR3-ANCA–positive patients with AAV compared to healthy individuals. Excessive NET formation did not correlate with serum ANCA levels. Likewise, immunoglobulin G depletion had no effect on excessive NET formation in patients with AAV, indicating an ANCA-independent process. Next, we explored the relation of excessive NET formation to clinical disease in ten patients with AAV and showed that excessive NET formation was predominantly found during active disease, more so than during remission. Excessive NET formation was found in patients with AAV hospitalized for disease relapse but not during severe infection. Thus, excessive NET formation in AAV is independent of ANCA, and an excess of ex vivoNET formation was related to active clinical disease in patients with AAV and a marker of autoimmunity rather than infection.
- Published
- 2018
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18. Small Intestinal Glucose Absorption and Duodenal Motility in Type 1 Diabetes Mellitus
- Author
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Rayner, C. K., primary, Schwartz, M. P., additional, van Dam, P. S., additional, Renooij, W., additional, de Smet, M., additional, Horowitz, M., additional, Smout, A. J. P. M., additional, and Samsom, M., additional
- Published
- 2002
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19. Measuring physical activity in patients after surgery for a malignant tumour in the leg
- Author
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van Dam, M. S., Kok, G. J., Munneke, M., Vogelaar, F. J., Vlieland, T. P. M. Vliet, and Taminiau, A. H. M.
- Abstract
A continuous ambulatory activity monitor allows objective measurement of the amount and intensity of physical activity. We examined the reliability and validity of this device in the assessment of seven aspects of function over a period of 24 hours in 20 patients who had undergone limb salvage or amputation for a tumour in the leg.The test-retest reliability was determined by undertaking identical assessments on two separate days. The measurements were compared with other indicators of functional status and quality of life in order to determine the validity of the monitor.Its reliability was satisfactory, with intraclass correlation coefficients ranging from 0.65 to 0.91. Significant correlations were seen between the ‘time spent walking’ and the Musculoskeletal Tumor Society rating scales and the Rand-36 physical functioning score. There was also a significant association between the ‘movement intensity during walking’ and the Musculoskeletal Tumor Society score. The satisfactory reliability and validity of the monitor shows considerable promise for its use as a device for measuring physical activity objectively in patients after surgery for limb-salvage or an amputation.
- Published
- 2001
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20. The immunological architecture of granulomatous inflammation in central nervous system tuberculosis.
- Author
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Zaharie, Stefan-Dan, Franken, Daniel J., van der Kuip, Martijn, van Elsland, Sabine, de Bakker, Bernadette S., Hagoort, Jaco, Roest, Sanna L., van Dam, Carmen S., Timmers, Carlie, Solomons, Regan, van Toorn, Ronald, Kruger, Mariana, and Marceline van Furth, A.
- Abstract
Of all tuberculosis (TB) cases, 1% affects the central nervous system (CNS), with a mortality rate of up to 60%. Our aim is to fill the 'key gap' in TBM research by analyzing brain specimens in a unique historical cohort of 84 patients, focusing on granuloma formation. We describe three different types: non-necrotizing, necrotizing gummatous, and necrotizing abscess type granuloma. Our hypothesis is that these different types of granuloma are developmental stages of the same pathological process. All types were present in each patient and were mainly localized in the leptomeninges. Intra-parenchymal granulomas were less abundant than the leptomeningeal ones and mainly located close to the cerebrospinal fluid (subpial and subependymal). We found that most of the intraparenchymal granulomas are an extension of leptomeningeal lesions which is the opposite of the classical Rich focus theory. We present a 3D-model to facilitate further understanding of the topographic relation of granulomas with leptomeninges, brain parenchyma and blood vessels. We describe innate and adaptive immune responses during granuloma formation including the cytokine profiles. We emphasize the presence of leptomeningeal B-cell aggregates as tertiary lymphoid structures. Our study forms a basis for further research in neuroinflammation and infectious diseases of the CNS, especially TB. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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21. Civil aviation in the area of the European civil aviation conference: possible developments
- Author
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van Dam, J. S. and Kok, P. J.
- Abstract
The development of European civil aviation shows a swing from pure nationalism towards more co-operation, increasingly institutionalized with the growing unification and prosperity of Europe. But this co-operation is obstructed by the characteristics of today's civil aviation. Likewise the European Economic Community has been blocking co-operation in the 22 countries of the European Civil Aviation Conference. The difficulties facing European scheduled air services emphasize the need to re-model European civil aviation.The creation of an air transport system in Europe should agree with the general regulations of the EEC treaty. A system regardless of national frontiers would fit EEC law and should benefit the consumer, as a more efficient network should lead to lower tariffs, if IATA price-fixing can be abolished.Such a system would probably cause substantial problems for those airlines that profit most from today's system.
- Published
- 1981
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22. The Accuracy of Four Frequently Used Frailty Instruments for the Prediction of Adverse Health Outcomes Among Older Adults at Two Dutch Emergency Departments: Findings of the AmsterGEM Study
- Author
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van Dam, Carmen S., Trappenburg, Marijke C., ter Wee, Marieke M., Hoogendijk, Emiel O., de Vet, Henrica C., Smulders, Yvo M., Nanayakkara, Prabath W., Muller, Majon, and Peters, Mike J.
- Abstract
Older adults presenting to the emergency department (ED) are at high risk of adverse health outcomes. This study aimed to evaluate the accuracy of 4 frequently used screening instruments for the prediction of adverse health outcomes among older adults in the ED.
- Published
- 2021
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23. Altered mental status in a young male.
- Author
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Pols AD, van Dam PS, and van den Berk GE
- Subjects
- Humans, Male
- Published
- 2012
24. Cognitive performance in older males is associated with growth hormone secretion.
- Author
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Quik EH, Conemans EB, Valk GD, Kenemans JL, Koppeschaar HP, and van Dam PS
- Subjects
- Aged, Cerebral Cortex metabolism, Cognition Disorders metabolism, Human Growth Hormone deficiency, Humans, Male, Middle Aged, Neuropsychological Tests, Aging physiology, Cerebral Cortex physiopathology, Cognition Disorders physiopathology, Human Growth Hormone metabolism
- Abstract
Decreases in GH secretion with age may contribute to cognitive changes associated with aging. We evaluated the relation between GH secretion and cognition in elderly males by assessing correlations between GH secretion and performance on cognitive tests in conjunction with recording of event-related potentials (ERPs) to assess underlying neurophysiological mechanisms. GH secretion of 17 elderly male participants was assessed by a GHRH-GHRP-6 test. Standardized neuropsychological tests were used to assess cognitive function. EEG/ERPs were recorded to assess on-line electrocortical correlates of sensory-cortical processing and selective attention. GH secretion was significantly correlated with target detections and speed of responding in the selection-potential task. Furthermore, GH peak was significantly correlated with the performance letter-digit span test. The present data confirm that cognitive performance in elderly males is associated with GH secretion, with respect to target detection and speed of responding in conditions of selective attention, short-term memory, and basic processing speed., (Copyright © 2012 Elsevier Inc. All rights reserved.)
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- 2012
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25. Reduced growth hormone secretion after cranial irradiation contributes to neurocognitive dysfunction.
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Quik EH, Valk GD, Drent ML, Stalpers LJ, Kenemans JL, Koppeschaar HP, and van Dam PS
- Subjects
- Adult, Aged, Cognition Disorders etiology, Female, Humans, Insulin-Like Growth Factor I metabolism, Male, Middle Aged, Radiation Injuries etiology, Cognition Disorders psychology, Cranial Irradiation adverse effects, Human Growth Hormone metabolism, Radiation Injuries psychology
- Abstract
The objective of this study was to investigate the relation between growth hormone (GH) and attentional electro-cortical responses to task-relevant stimuli (N2b), target detections, speed of responding, P300 latencies, and performance on neuropsychological tests in 19 patients who received external beam radiation therapy for brain tumors in adulthood. In addition, we studied the association between IGF-I and activation of the motor cortex responses (lateralized readiness potential, LRP). Brain function was assessed using event-related potentials (ERPs) during a go/no go selective-attention task, including N2b, P300 and selective motor preparation as reflected in the LRP. Correlations were calculated between peak GH levels after a standardized growth hormone-releasing hormone (GHRH)-arginine test, plasma IGF-I, and cognitive functions. We separately studied four patients who were diagnosed with GHD according to the GHRH-arginine test. Performance on WAIS digit span backward and the Rey-Osterrieth complex figure test correlated positively with GH peak. GHD patients performed worse than non-GHD patients on Stroop interference, trail making B/A attentional shifting and Rey-Osterrieth complex figure test. At trend-level significance, trails A performance was better in patients with lower GH levels and higher radiation doses, and GHD participants detected fewer targets in the go/no go selective attention task. N2b was not significantly altered by GH status. Furthermore, plasma IGF-I was positively correlated with the sum of digit span forward and backward. No relations with P300 were observed. In this study only 21% (4/19) of the patients who received fractionated radiotherapy for a non-endocrine brain tumor were diagnosed with GHD. GHD in these patients was associated with impaired interference control, attentional shifting, and visual long-term memory. The results for interference control and attentional shifting suggest an additional effect of the radiation history., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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26. [The adrenocortical carcinoma, a tumour of wide clinical diversity].
- Author
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Schreinemakers JM, van Dam PS, Seldenrijk CA, Biesma DH, and Borel Rinkes IH
- Subjects
- Adrenal Cortex Neoplasms pathology, Adrenal Cortex Neoplasms surgery, Adrenocortical Carcinoma secondary, Adrenocortical Carcinoma surgery, Bone Neoplasms secondary, Diagnosis, Differential, Fatal Outcome, Female, Humans, Liver Neoplasms secondary, Middle Aged, Adrenal Cortex Neoplasms diagnosis, Adrenocortical Carcinoma diagnosis
- Abstract
Over the course of a few years, an obese 52-year-old woman with a 23-year history of hypertension developed a number of abdominal complaints including gall stones. Her blood pressure became increasingly difficult to control and she developed diabetes mellitus and suffered palpitations and headaches. It became noticeable that she had a moon face. Laboratory tests revealed hypercortisolism. CT-scan showed a large inhomogeneous mass of nine centimetres in her left adrenal gland, which was subsequently removed surgically. The histopathological diagnosis was consistent with an adenoma. After a number of months the patient developed bone and liver metastases and the diagnosis was amended to carcinoma of the adrenal cortex. She then underwent radiotherapy and chemotherapy treatment. One year after surgery she developed a pancytopenia and died. Adrenocortical carcinomas are rare tumours with an incidence of about 1-2 cases per million of the population. Symptoms are heterogeneous since both functional (hormonal overproduction) and non-functional (mass effect) tumours exist. Surgical resection is the only curative therapy. It may be difficult to distinguish between benign and malignant cortical tumours.
- Published
- 2004
27. alpha-Tocopherol levels in plasma in new-onset, insulin-dependent diabetes mellitus.
- Author
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Muis MJ, Stolk RP, Princen HM, Van Dam PS, Dikkeschei LD, Grobbee DE, and Bilo HJ
- Abstract
BACKGROUND: Diabetic complications have been related to increased oxidative stress. Plasma antioxidant levels may be affected by hyperglycemia-induced oxidative stress as well as by insulin therapy. We evaluated the immediate effect of insulin treatment and improved metabolic control on the important antioxidant alpha-tocopherol plasma (vitamin E) levels in new-onset, insulin-dependent diabetes mellitus. METHODS: The study was performed in 15 consecutive patients, aged 20-67 years, with new-onset diabetes mellitus requiring acute insulin treatment. Plasma alpha-tocopherol levels were measured before the start of intensive insulin treatment and monthly for 6 months thereafter. Simultaneously, we studied plasma malondialdehyde (MDA) as a reflection of lipid peroxidation. In addition, comparisons were made to a nondiabetic reference group. RESULTS: Baseline alpha-tocopherol levels did not differ from those in nondiabetic subjects. alpha-Tocopherol decreased significantly, from 33.5+/-12.1 mumol/l before treatment to 28.11+/-6.85 mumol/l (-16%) after 1 month of insulin therapy (p<0.04) to 26.6+/-7.03 mumol/l (-20%) after 3 months of insulin therapy (p<0.02). This trend did not change after adjusting for variations in cholesterol levels. After 6 months, alpha-tocopherol was no longer decreased compared to baseline levels (29.6+/-7.4 mumol/l). MDA concentrations at baseline were significantly higher in the diabetic patients (3.79+/-2.91 mumol/l) than in the nondiabetic subjects (1.57+/-0.21 mumol/l, p=0.006). MDA concentrations decreased significantly following the start of insulin treatment. CONCLUSIONS: Patients with new-onset, insulin-dependent diabetes mellitus have alpha-tocopherol levels that are similar to those in normal subjects. Insulin treatment and/or improved metabolic control cause a significant decrease in alpha-tocopherol levels during the first months.
- Published
- 2004
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28. Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.
- Author
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Lijffijt M, Van Dam PS, Kenemans JL, Koppeschaar HP, de Vries WR, Drent ML, Wittenberg A, and Kemner C
- Subjects
- Adolescent, Adult, Evoked Potentials, Humans, Male, Pattern Recognition, Visual physiology, Photic Stimulation, Attention physiology, Brain physiology, Human Growth Hormone deficiency, Insulin-Like Growth Factor I deficiency
- Abstract
Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning.
- Published
- 2003
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29. Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state.
- Author
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van Dam PS, van Asbeck BS, Van Oirschot JF, Biessels GJ, Hamers FP, and Marx JJ
- Subjects
- Animals, Antioxidants metabolism, Blood Flow Velocity drug effects, Diabetes Mellitus, Experimental blood, Diabetic Neuropathies blood, Glutathione administration & dosage, Injections, Intraperitoneal, Male, Microcirculation drug effects, Microcirculation physiopathology, Neural Conduction drug effects, Peripheral Nerves drug effects, Rats, Rats, Wistar, Sciatic Nerve blood supply, Thioctic Acid administration & dosage, Tibial Nerve blood supply, Vascular Resistance drug effects, Diabetes Mellitus, Experimental metabolism, Diabetes Mellitus, Experimental physiopathology, Diabetic Neuropathies metabolism, Diabetic Neuropathies physiopathology, Glutathione metabolism, Oxidative Stress drug effects, Peripheral Nerves blood supply, Peripheral Nerves physiopathology, Thioctic Acid metabolism
- Abstract
Background: Increased oxidative stress is considered to be a causal factor in the development of diabetic complications, among which peripheral neuropathy. The pathophysiology of nerve dysfunction in diabetes has been explained both by reduced endoneurial microcirculation and alterations in endoneurial metabolism. It is unclear whether antioxidants primarily improve nerve blood flow or normalise systemic or endoneurial oxidative metabolism. Therefore, we evaluated the effects of the antioxidants glutathione and alpha-lipoic acid on both nerve microcirculation and the antioxidative capacity and lipid peroxidation in experimentally diabetic rats., Materials and Methods: Streptozotocin-diabetic rats were treated with different doses of alpha-lipoic acid, reduced glutathione or placebo, and were compared with nondiabetic controls. We measured systemic and endoneurial antioxidants, malondialdehyde and whole blood hydrogen peroxide. Furthermore, we evaluated sciatic and tibial motor and sensory nerve conduction velocity, caudal nerve conduction velocity, and assessed sciatic nerve blood flow and vascular resistance by Laser-Doppler flowmetry., Results: We observed a rise in erythrocyte glutathione by 27 % (P < 0.05), and a trend towards decreased plasma malondialdehyde in alpha-lipoic acid, but not in glutathione-treated animals in comparison with the placebo group. Simultaneously, sciatic nerve blood flow and vascular resistance were improved by daily alpha-lipoic acid administration by 38% (P < 0.05). Peripheral nerve conduction velocity and endoneurial glutathione were not significantly influenced by antioxidant treatment., Conclusions: Only minor beneficial effects of alpha-lipoic acid on nerve blood flow and oxidative state occur at the given doses; these effects were insufficient to improve nerve conduction deficits.
- Published
- 2001
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30. Reduction of free fatty acids by acipimox enhances the growth hormone (GH) responses to GH-releasing peptide 2 in elderly men.
- Author
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Van Dam PS, Smid HE, de Vries WR, Niesink M, Bolscher E, Waasdorp EJ, Dieguez C, Casanueva FF, and Koppeschaar HP
- Subjects
- Aged, Area Under Curve, Blood Glucose metabolism, Female, Growth Hormone-Releasing Hormone pharmacology, Humans, Insulin blood, Insulin Resistance, Insulin-Like Growth Factor Binding Protein 1 metabolism, Male, Obesity blood, Fatty Acids, Nonesterified blood, Hormones pharmacology, Human Growth Hormone blood, Hypolipidemic Agents therapeutic use, Oligopeptides pharmacology, Pyrazines therapeutic use
- Abstract
GH release is increased by reducing circulating free fatty acids (FFAs). Aging is associated with decreased plasma GH concentrations. We evaluated GH releasing capacity in nine healthy elderly men after administration of GH-releasing peptide 2 (GHRP-2), with or without pretreatment with the antilipolytic drug acipimox, and compared the GHRP-2-induced GH release with the response to GHRH. The area under the curve (AUC) of the GH response after GHRP-2 alone was 4.8 times higher compared with GHRH alone (1834 +/- 255 vs. 382 +/- 78 microg/L.60 min, P: < 0.001). Acipimox, which reduced FFAs from 607 micromol/L to 180 micromol/L, increased the GH AUC to 1087 after GHRH and to 2956 microg/L.60 min after GHRP-2 (P: < 0.01). The AUC after acipimox/GHRP-2 were positively correlated with the AUC after GHRP-2 alone (r = 0.93, P: < 0.01); this was also observed between acipimox/GHRH and GHRH alone (r = 0.73, P: = 0.03). Significant negative correlations were observed between basal FFAs and AUC after GHRH or GHRP-2 after combining the data with and without acipimox (r = 0.58, P: = 0.01 and r = 0.48, P: = 0.04, respectively), and between basal FFAs and GH at t = 0 (r = -0.44, P: = 0.001). Interestingly, GHRP-2 administration was followed by a significant early rise in plasma FFAs by 60% (P = 0.01), indicating an acute lipolytic effect. In conclusion, reduction of circulating FFAs strongly enhances GHRP-2-stimulated GH release in elderly men. The data indicate that the decreased GH release associated with aging can be reversed by acipimox and that the pituitary GH secretory capacity in elderly men is still sufficient.
- Published
- 2000
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31. Growth hormone, insulin-like growth factor I and cognitive function in adults.
- Author
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van Dam PS, Aleman A, de Vries WR, Deijen JB, van der Veen EA, de Haan EH, and Koppeschaar HP
- Subjects
- Adult, Age Factors, Age of Onset, Aging, Binding Sites, Brain metabolism, Central Nervous System metabolism, Female, Humans, Learning, Male, Memory, Sex Factors, Cognition, Growth Hormone biosynthesis, Growth Hormone deficiency, Insulin-Like Growth Factor I biosynthesis
- Abstract
This review focuses on the possible contribution of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis to cognitive function. Binding sites for GH and IGF-I are found in various areas of the brain. Their distribution suggests that GH and IGF-I contribute to the function of the hippocampus, a brain structure important for the maintenance of cognitive functions such as learning and memory. Evidence for cognitive deficits in GH-deficient individuals has been found in various studies, some of which have shown that these deficits can be reversed by GH substitution therapy. In addition to examining conditions of GH deficiency, this article reviews studies evaluating the correlation between the cognitive deficits associated with ageing and age-related decreases in GH or IGF-I secretion. Based on the available data, one might hypothesize that relative GH or IGF-I deficiency could contribute to the deterioration of cognitive functions observed in the elderly.
- Published
- 2000
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- View/download PDF
32. [Diabetic peripheral neuropathy: international guidelines for prevention, diagnosis, and treatment].
- Author
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van Dam PS, Valk GD, and Bakker K
- Subjects
- Amputation, Surgical, Diabetic Foot etiology, Diabetic Foot surgery, Humans, International Cooperation, Netherlands, Practice Guidelines as Topic standards, Risk Factors, Diabetic Foot prevention & control, Diabetic Neuropathies complications, Diabetic Neuropathies diagnosis, Diabetic Neuropathies prevention & control, Diabetic Neuropathies therapy
- Abstract
Recently, international guidelines for the diagnosis and management of diabetic polyneuropathy were issued. The aim of this initiative was to develop simple and practical guidelines for general practitioners and hospital physicians in day-to-day practice. Regular assessment of peripheral nerve function can be performed in diabetic patients using simple diagnostic tools. In such a way, patients will become more aware of the risks associated with diabetic neuropathy. Early detection of neuropathy and other risk factors for the development of foot ulcers may lead to avoidance of amputations. The guidelines emphasize foot care education of diabetic patients with or without neuropathy and early referral of patients with ulcerations to specialised outpatient foot clinic.
- Published
- 2000
33. High rat food vitamin E content improves nerve function in streptozotocin-diabetic rats.
- Author
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van Dam PS, Bravenboer B, van Asbeck BS, Marx JJ, and Gispen WH
- Subjects
- Animals, Anti-Bacterial Agents, Antioxidants administration & dosage, Diabetes Mellitus, Experimental chemically induced, Diabetes Mellitus, Experimental physiopathology, Diabetic Neuropathies physiopathology, Male, Rats, Rats, Wistar, Streptozocin, Vitamin E administration & dosage, Antioxidants therapeutic use, Diabetes Mellitus, Experimental drug therapy, Diabetic Neuropathies drug therapy, Food, Fortified, Neural Conduction drug effects, Vitamin E therapeutic use
- Abstract
Antioxidants can improve nerve dysfunction in hyperglycaemic rats. We evaluated whether the standard supplementation of rat food with vitamin E (normally added for preservation purposes) or high-dose vitamin E treatment improves nerve conduction in maturing streptozotocin-diabetic rats, a model widely used to study diabetic neuropathy. Hyperglycaemic rats received food containing 25 mg/kg (non-supplemented), 70 mg/kg (standard food) or 12 g/kg (high-dose) vitamin E. Non-diabetic controls received non-supplemented food. Sciatic and tibial sensory and motor nerve conduction velocity were decreased in all diabetic animals. In comparison with standard feeding, the non-supplemented diabetic rats showed lower plasma vitamin E levels but no significant change in nerve conduction. High-dose treatment prevented nerve dysfunction by 50%, and led to attenuated endoneurial lipid peroxidation (measured as malondialdehyde). We conclude that high doses of vitamin E, but not standard vitamin E supplementation of rat food partially prevent nerve dysfunction in young adult streptozotocin-diabetic rats.
- Published
- 1999
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34. Nerve conduction and antioxidant levels in experimentally diabetic rats: effects of streptozotocin dose and diabetes duration.
- Author
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Van Dam PS, Van Asbeck BS, Bravenboer B, Van Oirschot JF, Marx JJ, and Gispen WH
- Subjects
- Animals, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents toxicity, Blood Glucose metabolism, Body Weight physiology, Dose-Response Relationship, Drug, Erythrocytes metabolism, Male, Oxidative Stress drug effects, Rats, Rats, Wistar, Sciatic Nerve metabolism, Streptozocin administration & dosage, Streptozocin toxicity, Time Factors, Antioxidants metabolism, Diabetes Mellitus, Experimental metabolism, Diabetes Mellitus, Experimental physiopathology, Neural Conduction physiology
- Abstract
Oxidative stress supposedly plays a role in the pathogenesis of diabetic neuropathy. We have studied whether a variation in the streptozotocin (STZ) dose or diabetes duration affects the outcome of measurements of oxidative damage in relation to nerve conduction. In experiment 1, we induced diabetes in rats using 40 or 60 mg/kg STZ intravenously and assessed sciatic nerve conduction velocity. After 18 weeks, we measured plasma malondialdehyde (MDA) and red blood cell (RBC) and nerve glutathione levels. We observed a dose-dependent effect of STZ on body weight, and to a lesser extent on nerve conduction, but not on RBC or nerve glutathione and plasma MDA. In experiment 2, we administered a fixed dose of STZ (40 mg/kg) and measured antioxidants and MDA in RBCs, plasma, and sciatic nerve after 2, 4, 8, and 18 weeks in diabetic and control rats. RBC glutathione decreased in diabetic animals initially, but did not differ from control values after week 4. Plasma total glutathione increased until week 8. The ratio of total to oxidized glutathione in the sciatic nerve from diabetic animals paralleled the decrease observed in RBCs, and subsequently increased compared with controls. Nerve catalase increased in diabetic animals. Endoneurial MDA remained unchanged, whereas plasma MDA increased and RBC superoxide dismutase (SOD) decreased in the diabetic group. We conclude that differences in antioxidant levels between STZ-diabetic and control rats depend on the duration of hyperglycemia. Furthermore, dose-related effects of STZ on nerve conduction are not reflected in endoneurial lipid peroxidation or glutathione.
- Published
- 1999
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- View/download PDF
35. Nerve function and oxidative stress in diabetic and vitamin E-deficient rats.
- Author
-
van Dam PS, van Asbeck BS, Bravenboer B, van Oirschot JF, Gispen WH, and Marx JJ
- Subjects
- Animals, Antioxidants metabolism, Diabetes Mellitus, Experimental complications, Hydrogen Peroxide blood, Male, Malondialdehyde blood, Microcirculation, Neural Conduction physiology, Peripheral Nerves blood supply, Rats, Rats, Wistar, Sciatic Nerve metabolism, Diabetes Mellitus, Experimental physiopathology, Diabetic Neuropathies physiopathology, Oxidative Stress physiology, Reactive Oxygen Species metabolism, Vitamin E Deficiency physiopathology
- Abstract
Nerve dysfunction in diabetes is associated with increased oxidative stress. Vitamin E depletion also leads to enhanced presence of reactive oxygen species (ROS). We compared systemic and endoneurial ROS activity and nerve conduction in vitamin E-depleted control and streptozotocin-diabetic rats (CE- and DE-), and in normally fed control and diabetic animals (CE+ and DE+). Nerve conduction was reduced in both diabetic groups. Vitamin E depletion caused a small further nerve conduction deficit in the diabetic, but not in the control animals. The combination of vitamin E deficiency and streptozotocin-diabetes (group DE-) appeared to be lethal. In the remaining groups, an important rise in sciatic nerve malondialdehyde (MDA) was observed in the vitamin E-depleted control rats. In contrast, plasma MDA levels were elevated in group DE+ only, whereas hydrogen peroxide levels were increased in group CE-. Endoneurial total and oxidized glutathione and catalase were predominantly elevated in group DE+. These data show that nerve lipid peroxidation induced by vitamin E depletion does not lead to reduced nerve conduction or changes in antioxidant concentrations as observed in STZ-diabetes. The marked systemic changes in MDA and antioxidants suggest that nerve dysfunction in experimental hyperglycemia is rather a consequence of systemic than direct nerve damage.
- Published
- 1998
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- View/download PDF
36. The role of oxidative stress in neuropathy and other diabetic complications.
- Author
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Van Dam PS, Van Asbeck BS, Erkelens DW, Marx JJ, Gispen WH, and Bravenboer B
- Subjects
- Animals, Diabetes Mellitus physiopathology, Diabetes Mellitus, Experimental complications, Diabetes Mellitus, Experimental physiopathology, Humans, Diabetes Complications, Diabetic Neuropathies physiopathology, Oxidative Stress physiology
- Published
- 1995
- Full Text
- View/download PDF
37. Antihypoxic treatment at an early stage of diabetic neuropathy: an electrophysiological study with sabeluzole.
- Author
-
Hendriksen PH, Oey PL, Wieneke GH, Banga JD, and van Dam PS
- Subjects
- Adult, Aged, Autonomic Nervous System Diseases drug therapy, Autonomic Nervous System Diseases physiopathology, Cell Hypoxia drug effects, Diabetes Mellitus, Type 2 drug therapy, Diabetic Neuropathies drug therapy, Double-Blind Method, Electromyography drug effects, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nerve Degeneration drug effects, Neurologic Examination, Sensory Thresholds drug effects, Sensory Thresholds physiology, Synaptic Transmission drug effects, Synaptic Transmission physiology, Cell Hypoxia physiology, Diabetes Mellitus, Type 2 physiopathology, Diabetic Neuropathies physiopathology, Nerve Degeneration physiology, Peripheral Nerves blood supply, Piperidines therapeutic use, Thiazoles therapeutic use
- Abstract
Thirty-seven non-IDDM patients at an early stage of polyneuropathy, defined as the presence of symptoms for less than two years, as well as an abnormal perception threshold and/or abnormal thermal discrimination threshold, were treated with sabeluzole, a new antihypoxic drug, or placebo for 1 year in a double-blind, placebo-controlled study. They were examined neurophysiologically every 3 months, when motor (tibial, ulnar) nerve and sensory (sural, ulnar) nerve conduction velocities, H-reflex of the soleus muscle, SF-EMG of the anterior tibial muscle, static and dynamic pupillometry were measured. Statistical analysis did not show significant differences in nerve function between the sabeluzole group and the placebo group. There were also no significant changes within each group over the 1-year period. The results of the present study show no beneficial effect of sabeluzole on peripheral nerve function in patients at an early stage of diabetic polyneuropathy.
- Published
- 1992
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38. Thermal threshold testing for the assessment of small fibre dysfunction: normal values and reproducibility.
- Author
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Bravenboer B, van Dam PS, Hop J, vd Steenhoven J, and Erkelens DW
- Subjects
- Adult, Age Factors, Diabetic Neuropathies diagnosis, Diabetic Neuropathies physiopathology, Female, Foot innervation, Hand innervation, Humans, Male, Middle Aged, Reference Values, Sensory Thresholds, Nerve Fibers physiology, Skin innervation, Temperature
- Abstract
Small and large fibre neuropathy are common findings in patients with long-standing diabetes mellitus. The Thermal Threshold Tester was tested to obtain normal values for thermal perception threshold for warmth and cold. This device produces thermal stimuli by means of a Peltier element placed on the skin. Warm and cold thresholds are measured using a forced choice method with an up-and-down-transform rule and expressed in degrees Celsius (degree C). Thresholds were measured at the right wrist and right foot in 80 normal subjects, divided into four age groups; 25-34, 35-44, 45-54, and 55-65 years. The repeatability coefficient was assessed by twice measuring 39 diabetic patients without known neuropathy. Warm thermal threshold in the hand showed a significant increase with age from 0.09 +/- 0.5 (mean +/- SD) in the youngest age group to 0.17 +/- 0.08 degree C (p less than 0.05) in the oldest age group. Cold thermal threshold in the hand (varying between 0.08 +/- 0.04 and 0.14 +/- 0.05 degree C) and warm thermal threshold in the foot (varying between 2.45 +/- 1.93 and 4.06 +/- 2.57 degrees C) did not differ significantly between the four age groups. There was a significant increase in cold thermal threshold in the foot with age, increasing from 0.31 +/- 0.24 to 0.56 +/- 0.44 degree C (p less than 0.05). Reproducibility in the diabetic subjects was good for measurements of warm and cold threshold in the hand, but poor for warm threshold in the foot in the normal range and for cold thermal threshold in the abnormal range.
- Published
- 1992
- Full Text
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