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48 results on '"Van Cauwenberghe, Caroline"'

7. Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease

Author

Jansen, Maurice P.H.M., Sas, Leen, Sieuwerts, Anieta M., Van Cauwenberghe, Caroline, Ramirez-Ardila, Diana, Look, Maxime, Ruigrok-Ritstier, Kirsten, Finetti, Pascal, Bertucci, François, Timmermans, Mieke M., van Deurzen, Carolien H.M., Martens, John W.M., Simon, Iris, Roepman, Paul, Linn, Sabine C., van Dam, Peter, Kok, Marleen, Lardon, Filip, Vermeulen, Peter B., Foekens, John A., Dirix, Luc, Berns, Els M.J.J., and Van Laere, Steven

Published
2015
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11. A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study

Author

Gijselinck, Ilse, Van Langenhove, Tim, van der Zee, Julie, Sleegers, Kristel, Philtjens, Stéphanie, Kleinberger, Gernot, Janssens, Jonathan, Bettens, Karolien, Van Cauwenberghe, Caroline, Pereson, Sandra, Engelborghs, Sebastiaan, Sieben, Anne, De Jonghe, Peter, Vandenberghe, Rik, Santens, Patrick, De Bleecker, Jan, Maes, Githa, Bäumer, Veerle, Dillen, Lubina, Joris, Geert, Cuijt, Ivy, Corsmit, Ellen, Elinck, Ellen, Van Dongen, Jasper, Vermeulen, Steven, Van den Broeck, Marleen, Vaerenberg, Carolien, Mattheijssens, Maria, Peeters, Karin, Robberecht, Wim, Cras, Patrick, Martin, Jean-Jacques, De Deyn, Peter P, Cruts, Marc, and Van Broeckhoven, Christine

Published
2012
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13. Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann–Pick Type C Disease

Author

Van Hoecke, Lien, primary, Van Cauwenberghe, Caroline, additional, Börger, Verena, additional, Bruggeman, Arnout, additional, Castelein, Jonas, additional, Van Imschoot, Griet, additional, Van Wonterghem, Elien, additional, Dittrich, Robin, additional, Claeys, Wouter, additional, Xie, Junhua, additional, Giebel, Bernd, additional, and Vandenbroucke, Roosmarijn E., additional

Published
2021
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14. Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

Author

Van Hoecke, Lien, primary, Van Cauwenberghe, Caroline, additional, Dominko, Kristina, additional, Van Imschoot, Griet, additional, Van Wonterghem, Elien, additional, Castelein, Jonas, additional, Xie, Junhua, additional, Claeys, Wouter, additional, Vandendriessche, Charysse, additional, Kremer, Anna, additional, Borghgraef, Peter, additional, De Rycke, Riet, additional, Hecimovic, Silva, additional, and Vandenbroucke, Roosmarijn E., additional

Published
2021
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15. Additional file 4 of Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer’s disease

Author

Xie, Junhua, Gorlé, Nina, Vandendriessche, Charysse, Van Imschoot, Griet, Van Wonterghem, Elien, Van Cauwenberghe, Caroline, Parthoens, Eef, Van Hamme, Evelien, Lippens, Saskia, Van Hoecke, Lien, and Vandenbroucke, Roosmarijn E.

Abstract

Additional file 4. Supplementary Figures S1-S12 and Appendix Tables S1-S2.

Published
2021
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16. Additional file 1 of Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

Author

Vandendriessche, Charysse, Balusu, Sriram, Van Cauwenberghe, Caroline, Brkic, Marjana, Pauwels, Marie, Plehiers, Nele, Bruggeman, Arnout, Dujardin, Pieter, Van Imschoot, Griet, Van Wonterghem, Elien, Hendrix, An, Baeke, Femke, De Rycke, Riet, Gevaert, Kris, and Vandenbroucke, Roosmarijn E.

Abstract

Additional file 1. Supplementary Figures S1-S6 and Appendix Table S1.

Published
2021
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22. Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer's disease.

Author

Xie, Junhua, Gorlé, Nina, Vandendriessche, Charysse, Van Imschoot, Griet, Van Wonterghem, Elien, Van Cauwenberghe, Caroline, Parthoens, Eef, Van Hamme, Evelien, Lippens, Saskia, Van Hoecke, Lien, and Vandenbroucke, Roosmarijn E.

Subjects
ENCEPHALITIS, ALZHEIMER'S disease, NEUROFIBRILLARY tangles, BRAIN diseases, AMYLOID beta-protein precursor, LABORATORY mice, BLOOD-brain barrier, CELL aggregation
Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflammation plays a key role in both the initiation and progression of AD. Moreover, also the presence of peripheral inflammation has been extensively documented. However, it is still ambiguous whether this observed inflammation is cause or consequence of AD pathogenesis. Recently, this has been studied using amyloid precursor protein (APP) overexpression mouse models of AD. However, the findings might be confounded by APP-overexpression artifacts. Here, we investigated the effect of low-grade peripheral inflammation in the APP knock-in (AppNL-G-F) mouse model. This revealed that low-grade peripheral inflammation affects (1) microglia characteristics, (2) blood-cerebrospinal fluid barrier integrity, (3) peripheral immune cell infiltration and (4) Aβ deposition in the brain. Next, we identified mechanisms that might cause this effect on AD pathology, more precisely Aβ efflux, persistent microglial activation and insufficient Aβ clearance, neuronal dysfunction and promotion of Aβ aggregation. Our results further strengthen the believe that even low-grade peripheral inflammation has detrimental effects on AD progression and may further reinforce the idea to modulate peripheral inflammation as a therapeutic strategy for AD. [ABSTRACT FROM AUTHOR]

Published
2021
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26. A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid <tex>A\beta_{42}$</tex>

Author

Sleegers, Kristel, Bettens, Karolien, De Roeck, Arne, Van Cauwenberghe, Caroline, Cuyvers, Elise, Verheijen, Jan, Struyfs, Hanne, Van Dongen, Jasper, Vermeulen, Steven, Engelborghs, Sebastiaan, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Deyn, Peter Paul, Van Broeckhoven, Christine, and BELNEU Consortium

Subjects
fungi, Human medicine, Biology
Abstract

Background The ability to identify individuals at increased genetic risk for Alzheimer's disease (AD) may streamline biomarker and drug trials and aid clinical and personal decision making. Methods We evaluated the discriminative ability of a genetic risk score (GRS) covering 22 published genetic risk loci for AD in 1162 Flanders-Belgian AD patients and 1019 controls and assessed correlations with family history, onset age, and cerebrospinal fluid (CSF) biomarkers (Aβ142, T-Tau, P-Tau181P). Results A GRS including all single nucleotide polymorphisms (SNPs) and age-specific APOE ε4 weights reached area under the curve (AUC) 0.70, which increased to AUC 0.78 for patients with familial predisposition. Risk of AD increased with GRS (odds ratio, 2.32 (95% confidence interval 2.082.58 per unit; P < 1.0e−15). Onset age and CSF Aβ142 decreased with increasing GRS (Ponset_age = 9.0e−11; PAβ = 8.9e−7). Conclusions The discriminative ability of this 22-SNP GRS is still limited, but these data illustrate that incorporation of age-specific weights improves discriminative ability. GRS-phenotype correlations highlight the feasibility of identifying individuals at highest susceptibility.

Published
2015

27. A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42

Author

Sleegers, Kristel, Bettens, Karolien, De Roeck, Arne, Van Cauwenberghe, Caroline, Cuyvers, Elise, Verheijen, Jan, Struyfs, Hanne, Van Dongen, Jasper, Vermeulen, Steven, Engelborghs, Sebastiaan, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Deyn, Peter Paul, Van Broeckhoven, Christine, BELNEU consortium, the, Santens, Patrick, De Bleecker, Jan, Sieben, Anne, Dermaut, Bart, BELNEU consortium, Molecular Neuroscience and Ageing Research (MOLAR), Clinical sciences, Neurology, and Pathologic Biochemistry and Physiology

Subjects
Oncology, Apolipoprotein E, Male, Genotype-phenotype correlation, Epidemiology, CLU, LOCI, Genome-wide association study, CD2AP, Bioinformatics, Alzheimer Disease/cerebrospinal fluid, 0302 clinical medicine, Belgium, Risk Factors, Medicine and Health Sciences, Family history, Age of Onset, Medicine(all), 0303 health sciences, DEMENTIA, Health Policy, Area under the curve, COMMON VARIANTS, Alzheimer's disease, Middle Aged, CSF Aβ1–42, Psychiatry and Mental health, Phenotype, CSFA beta(1-42), Biomarker (medicine), Female, Peptide Fragments/cerebrospinal fluid, EPHA1, APOE, medicine.medical_specialty, Genotype, Clinical Neurology, Single-nucleotide polymorphism, tau Proteins, Genotype-phenotype, Biology, IDENTIFIES VARIANTS, Polymorphism, Single Nucleotide, 03 medical and health sciences, Cellular and Molecular Neuroscience, Apolipoproteins E, Developmental Neuroscience, Alzheimer Disease, Internal medicine, medicine, Dementia, Humans, Biomarkers/cerebrospinal fluid, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, 030304 developmental biology, Aged, Amyloid beta-Peptides, fungi, Biology and Life Sciences, tau Proteins/cerebrospinal fluid, Odds ratio, medicine.disease, Amyloid beta-Peptides/cerebrospinal fluid, Peptide Fragments, Onset age, correlation, Genetic risk profile, Neurology (clinical), CD33, Geriatrics and Gerontology, Apolipoproteins E/genetics, 030217 neurology & neurosurgery, Biomarkers
Abstract

INTRODUCTION: The ability to identify individuals at increased genetic risk for Alzheimer's disease (AD) may streamline biomarker and drug trials and aid clinical and personal decision making. METHODS: We evaluated the discriminative ability of a genetic risk score (GRS) covering 22 published genetic risk loci for AD in 1162 Flanders-Belgian AD patients and 1019 controls and assessed correlations with family history, onset age, and cerebrospinal fluid (CSF) biomarkers (Aβ1-42, T-Tau, P-Tau181P). RESULTS: A GRS including all single nucleotide polymorphisms (SNPs) and age-specific APOE ε4 weights reached area under the curve (AUC) 0.70, which increased to AUC 0.78 for patients with familial predisposition. Risk of AD increased with GRS (odds ratio, 2.32 (95% confidence interval 2.08-2.58 per unit; P < 1.0e(-15)). Onset age and CSF Aβ1-42 decreased with increasing GRS (Ponset_age = 9.0e(-11); PAβ = 8.9e(-7)). DISCUSSION: The discriminative ability of this 22-SNP GRS is still limited, but these data illustrate that incorporation of age-specific weights improves discriminative ability. GRS-phenotype correlations highlight the feasibility of identifying individuals at highest susceptibility. publisher: Elsevier articletitle: A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42 journaltitle: Alzheimer's & Dementia articlelink: http://dx.doi.org/10.1016/j.jalz.2015.02.013 content_type: article copyright: Copyright © 2015 The Authors. Published by Elsevier B.V. ispartof: Alzheimer's & Dementia vol:11 issue:12 pages:1452-1460 ispartof: location:United States status: published

Published
2014

29. Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

Author

Van den Bossche, Tobi, primary, Sleegers, Kristel, additional, Cuyvers, Elise, additional, Engelborghs, Sebastiaan, additional, Sieben, Anne, additional, De Roeck, Arne, additional, Van Cauwenberghe, Caroline, additional, Vermeulen, Steven, additional, Van den Broeck, Marleen, additional, Laureys, Annelies, additional, Peeters, Karin, additional, Mattheijssens, Maria, additional, Vandenbulcke, Mathieu, additional, Vandenberghe, Rik, additional, Martin, Jean-Jacques, additional, De Deyn, Peter P., additional, Cras, Patrick, additional, and Van Broeckhoven, Christine, additional

Published
2016
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30. Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease

Author

Jansen, Maurice P. H. M., Sas, Leen, Sieuwerts, Anieta M., Van Cauwenberghe, Caroline, Ramirez-Ardila, Diana, Look, Maxime, Ruigrok-Ritstier, Kirsten, Finetti, Pascal, Bertucci, Francois, Timmermans, Mieke M., van Deurzen, Carolien H. M., Martens, John W. M., Simon, Iris, Roepman, Paul, Linn, Sabine C., van Dam, Peter, Kok, Marleen, Lardon, Filip, Vermeulen, Peter B., Foekens, John A., Dirix, Luc, Berns, Els M. J. J., Van Laere, Steven, Jansen, Maurice P. H. M., Sas, Leen, Sieuwerts, Anieta M., Van Cauwenberghe, Caroline, Ramirez-Ardila, Diana, Look, Maxime, Ruigrok-Ritstier, Kirsten, Finetti, Pascal, Bertucci, Francois, Timmermans, Mieke M., van Deurzen, Carolien H. M., Martens, John W. M., Simon, Iris, Roepman, Paul, Linn, Sabine C., van Dam, Peter, Kok, Marleen, Lardon, Filip, Vermeulen, Peter B., Foekens, John A., Dirix, Luc, Berns, Els M. J. J., and Van Laere, Steven

Published
2015

31. Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease

Author

Pathologie, Cancer, Jansen, Maurice P. H. M., Sas, Leen, Sieuwerts, Anieta M., Van Cauwenberghe, Caroline, Ramirez-Ardila, Diana, Look, Maxime, Ruigrok-Ritstier, Kirsten, Finetti, Pascal, Bertucci, Francois, Timmermans, Mieke M., van Deurzen, Carolien H. M., Martens, John W. M., Simon, Iris, Roepman, Paul, Linn, Sabine C., van Dam, Peter, Kok, Marleen, Lardon, Filip, Vermeulen, Peter B., Foekens, John A., Dirix, Luc, Berns, Els M. J. J., Van Laere, Steven, Pathologie, Cancer, Jansen, Maurice P. H. M., Sas, Leen, Sieuwerts, Anieta M., Van Cauwenberghe, Caroline, Ramirez-Ardila, Diana, Look, Maxime, Ruigrok-Ritstier, Kirsten, Finetti, Pascal, Bertucci, Francois, Timmermans, Mieke M., van Deurzen, Carolien H. M., Martens, John W. M., Simon, Iris, Roepman, Paul, Linn, Sabine C., van Dam, Peter, Kok, Marleen, Lardon, Filip, Vermeulen, Peter B., Foekens, John A., Dirix, Luc, Berns, Els M. J. J., and Van Laere, Steven

Published
2015

32. Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

Author

Bettens, Karolien, primary, Vermeulen, Steven, additional, Van Cauwenberghe, Caroline, additional, Heeman, Bavo, additional, Asselbergh, Bob, additional, Robberecht, Caroline, additional, Engelborghs, Sebastiaan, additional, Vandenbulcke, Mathieu, additional, Vandenberghe, Rik, additional, De Deyn, Peter Paul, additional, Cruts, Marc, additional, Van Broeckhoven, Christine, additional, and Sleegers, Kristel, additional

Published
2015
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33. P4-194: The identification of high-penetrant loss-of-function mutations in abca7 in Alzheimer's disease

Author

Cuyvers, Elise, primary, De Roeck, Arne, additional, Van den Bossche, Tobi, additional, Van Cauwenberghe, Caroline, additional, Bettens, Karolien, additional, Vermeulen, Steven, additional, Mattheijssens, Maria, additional, Peeters, Karin, additional, Engelborghs, Sebastiaan, additional, Vandenbulcke, Mathieu, additional, Vandenberghe, Rik, additional, De Deyn, Peter P., additional, Van Broeckhoven, Christine, additional, and Sleegers, Kristel, additional

Published
2015
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34. O4-04-03: HIGH SCORES ON A 22-GENE RISK SCORE FOR ALZHEIMER'S DEMENTIA CORRELATE WITH EARLIER ONSET AGE AND REDUCED CSF Aβ

Author

Bettens, Karolien, primary, Van Cauwenberghe, Caroline, additional, Cuyvers, Elise, additional, Verheijen, Jan, additional, De Roeck, Arne, additional, Van Dongen, Jasper, additional, Vermeulen, Steven, additional, Engelborghs, Sebastiaan, additional, Vandenbulcke, Mathieu, additional, Vandenberghe, Rik R., additional, De Deyn, Peter Paul, additional, Van Broeckhoven, Christine, additional, and Sleegers, Kristel, additional

Published
2014
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37. P4‐087: Genetic complexity in the BIN1 locus

Author

Mounier, Anaïs, primary, Hansmannel, Franck, additional, Chapuis, Julien, additional, Gistelinck, Marc, additional, Van Cauwenberghe, Caroline, additional, Grenier‐Bolay, Benjamin, additional, Van Broeckhoven, Christine, additional, Amouyel, Philippe, additional, Moechars, Diederik, additional, Dermaut, Bart, additional, and Lambert, Jean‐Charles, additional

Published
2012
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39. O1-01-06: Risk For Alzheimer's Associated with a Copy Number Variation In The Complement Receptor 1 Increasing C3b/C4b Binding Sites

Author

Brouwers, Nathalie, primary, Van Cauwenberghe, Caroline, additional, Engelborghs, Sebastiaan, additional, Lambert, Jean-Charles, additional, Bettens, Karolien, additional, Le Bastard, Nathalie, additional, Pasquier, Florence, additional, Vandenberghe, Rik, additional, De Deyn, Peter, additional, Cruts, Marc, additional, Amouyel, Philippe, additional, Sleegers, Kristel, additional, and Van Broeckhoven, Christine, additional

Published
2011
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46. Genetic complexity in the BIN1 locus

Author

Mounier, Anaïs, Hansmannel, Franck, Chapuis, Julien, Gistelinck, Marc, Van Cauwenberghe, Caroline, Grenier-Bolay, Benjamin, Van Broeckhoven, Christine, Amouyel, Philippe, Moechars, Diederik, Dermaut, Bart, and Lambert, Jean-Charles

Published
2012
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