1. Effects of anti-tumour necrosis factor-alpha therapy on the quality of life in Crohn's disease
- Author
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Van Balkom, BPJ, Schoon, EJ, Stockbrugger, RW, Wolters, FL, Van Hogezand, RA, Van Deventer, SJH, Van Dullemen, HM, Russel, MGVM, and Center for Liver, Digestive and Metabolic Diseases (CLDM)
- Subjects
INFLIXIMAB THERAPY ,CLINICAL-EXPERIENCE ,OF-LIFE ,CYTOKINES ,IMPROVES ,BRAIN ,EFFICACY ,INDEX ,INFLAMMATORY-BOWEL-DISEASE ,CA2 - Abstract
Background: Infusion of anti-tumour necrosis factor-alpha appears to be highly effective in patients with Crohn's disease. Aim: To assess the effect of infliximab on the quality of life in patients with active or fistulizing disease, as measured by the inflammatory bowel disease questionnaire, and to examine the impact on its four dimensions. Methods: An observational study was conducted in 65 patients. An infusion of 5 mg/kg infliximab was given at week 0 in patients with active disease and at week 0, 2 and 6 in fistulizing disease. Changes from baseline in the total and dimensional inflammatory bowel disease questionnaire scores were calculated and compared between the patient groups. Potential predictors of change in the quality of life were identified. Results: In the active disease group, at week 4, the mean total and dimensional inflammatory bowel disease questionnaire scores improved compared to baseline (P
- Published
- 2002