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13 results on '"Vameghestahbanati, Motahareh"'

2. Airway tree caliber heterogeneity and airflow obstruction among older adults

Author

Vameghestahbanati, Motahareh, primary, Kingdom, Leina, additional, Hoffman, Eric A., additional, Kirby, Miranda, additional, Allen, Norrina B., additional, Angelini, Elsa, additional, Bertoni, Alain, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Jacobs, David R., additional, Laine, Andrew, additional, Maltais, François, additional, Michos, Erin D., additional, Sack, Coralynn, additional, Sin, Don, additional, Watson, Karol E., additional, Wysoczanksi, Artur, additional, Couper, David, additional, Cooper, Christopher, additional, Han, MeiLan, additional, Woodruff, Prescott, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, Barr, R. Graham, additional, and Smith, Benjamin M., additional

Published
2024
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3. Association of dysanapsis with mortality among older adults

Author

Vameghestahbanati, Motahareh, primary, Sack, Coralynn, additional, Wysoczanski, Artur, additional, Hoffman, Eric A., additional, Angelini, Elsa, additional, Allen, Norrina B., additional, Bertoni, Alain G., additional, Guo, Junfeng, additional, Jacobs, David R., additional, Kaufman, Joel D., additional, Laine, Andrew, additional, Lin, Ching-Long, additional, Malinsky, Daniel, additional, Michos, Erin D., additional, Oelsner, Elizabeth C., additional, Shea, Steven J., additional, Watson, Karol E., additional, Benedetti, Andrea, additional, Barr, R. Graham, additional, and Smith, Benjamin M., additional

Published
2023
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6. Dysanapsis and the Spirometric Response to Inhaled Bronchodilators

Author

Vameghestahbanati, Motahareh, primary, Kirby, Miranda, additional, Maltais, François, additional, Jensen, Dennis, additional, Doiron, Dany, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, Smith, Benjamin M., additional, Lacasse, Yves, additional, O’Donnell, Denis, additional, Cowie, Robert, additional, Chapman, Kenneth, additional, Goldstein, Roger, additional, Marciniuk, Darcy, additional, Shawn, Aaron, additional, Benedetti, Andrea, additional, Hernandez, Paul, additional, Fitzgerald, Mark, additional, To, Teresa, additional, Perrault, Hélène, additional, Taivassalo, Tanja, additional, Sheel, William, additional, Pare, Peter, additional, and C. Hogg, James, additional

Published
2021
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7. Airway tree caliber across the adult lifespan

Author

Vameghestahbanati, Motahareh, primary, Hoffman, Eric, additional, Kirby, Miranda, additional, Sieren, Jessica, additional, Allen, Norrina, additional, Bertoni, Alain, additional, Cooper, Christopher, additional, Jacobs, David, additional, Hamid, Qutayba, additional, Han, Meilan, additional, Hansel, Nadia, additional, Hogg, James, additional, Jensen, Dennis, additional, Kanner, Richard, additional, Michos, Erin, additional, Oelsner, Elizabeth, additional, Sack, Coralynn, additional, Watson, Karol, additional, Couper, David, additional, Benedetti, Andrea, additional, Woodruff, Prescott, additional, Bourbeau, Jean, additional, Tan, Wan, additional, Barr, R. Graham, additional, and Smith, Benjamin, additional

Published
2021
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8. Airway tree caliber heterogeneity and airflow obstruction

Author

Vameghestahbanati, Motahareh, primary, Kingdom, Leina, additional, Anacleto-Dabarno, Matthew, additional, Hoffman, Eric, additional, Kirby, Miranda, additional, Allen, Norrina, additional, Angelini, Elsa, additional, Bertoni, Alain, additional, Hamid, Qutayba, additional, Hogg, James, additional, Jacobs, David, additional, Laine, Andrew, additional, Maltais, Francois, additional, Michos, Erin, additional, Sack, Coralynn, additional, Sin, Don, additional, Watson, Karol, additional, Wysoczanksi, Artur, additional, Tan, Wan, additional, Bourbeau, Jean, additional, Barr, R. Graham, additional, and Smith, Benjamin, additional

Published
2021
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9. Central Airway Tree Dysanapsis Extends to the Peripheral Airways

Author

Vameghestahbanati, Motahareh, primary, Kirby, Miranda, additional, Tanabe, Naoya, additional, Vasilescu, Dragoş M., additional, Janssens, Wim, additional, Everaerts, Stephanie, additional, Vanaudenaerde, Bart M., additional, Benedetti, Andrea, additional, Hogg, James C., additional, and Smith, Benjamin M., additional

Published
2021
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10. Evaluation of a home-based 7-day infection control strategy for healthcare workers following high-risk exposure to severe acute respiratory coronavirus virus 2 (SARS-CoV-2): A cohort study

Author

Benea, Carla, primary, Rendon, Laura, additional, Papenburg, Jesse, additional, Frenette, Charles, additional, Imacoudene, Ahmed, additional, McDonald, Emily G., additional, Nguyen, Quoc D., additional, Rajda, Ewa, additional, Tran, Estelle, additional, Vameghestahbanati, Motahareh, additional, Benedetti, Andrea, additional, Behr, Marcel A., additional, and Smith, Benjamin M., additional

Published
2020
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11. Evaluation of a home-based 7-day infection control strategy for healthcare workers following high-risk exposure to SARS-CoV-2: a cohort study

Author

Benea, Carla, primary, Rendon, Laura, additional, Papenburg, Jesse, additional, Frenette, Charles, additional, Imcaoudene, Ahmed, additional, McDonald, Emily G, additional, Nguyen, Quoc Dinh, additional, Rajda, Ewa, additional, Tran, Estelle, additional, Vameghestahbanati, Motahareh, additional, Benedetti, Andrea, additional, Behr, Marcel A, additional, and Smith, Benjamin M, additional

Published
2020
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12. Evaluation of a home-based 7-day infection control strategy for healthcare workers following high-risk exposure to severe acute respiratory coronavirus virus 2 (SARS-CoV-2): A cohort study

Author

Benea, Carla, Rendon, Laura, Papenburg, Jesse, Frenette, Charles, Imacoudene, Ahmed, McDonald, Emily G., Nguyen, Quoc D., Rajda, Ewa, Tran, Estelle, Vameghestahbanati, Motahareh, Benedetti, Andrea, Behr, Marcel A., and Smith, Benjamin M.

Abstract

AbstractObjective:Evidence-based infection control strategies are needed for healthcare workers (HCWs) following high-risk exposure to severe acute respiratory coronavirus virus 2 (SARS-CoV-2). In this study, we evaluated the negative predictive value (NPV) of a home-based 7-day infection control strategy.Methods:HCWs advised by their infection control or occupational health officer to self-isolate due to a high-risk SARS-CoV-2 exposure were enrolled between May and October 2020. The strategy consisted of symptom-triggered nasopharyngeal SARS-CoV-2 RNA testing from day 0 to day 7 after exposure and standardized home-based nasopharyngeal swab and saliva testing on day 7. The NPV of this strategy was calculated for (1) clinical coronavirus disease 2019 (COVID-19) diagnosis from day 8–14 after exposure, and for (2) asymptomatic SARS-CoV-2 detected by standardized nasopharyngeal swab and saliva specimens collected at days 9, 10, and 14 after exposure. Interim results are reported in the context of a second wave threatening this essential workforce.Results:Among 30 HCWs enrolled, the mean age was 31 years (SD, ±9), and 24 (80%) were female. Moreover, 3 were diagnosed with COVID-19 by day 14 after exposure (secondary attack rate, 10.0%), and all cases were detected using the 7-day infection control strategy: the NPV for subsequent clinical COVID-19 or asymptomatic SARS-CoV-2 detection by day 14 was 100.0% (95% CI, 93.1%–100.0%).Conclusions:Among HCWs with high-risk exposure to SARS-CoV-2, a home-based 7-day infection control strategy may have a high NPV for subsequent COVID-19 and asymptomatic SARS-CoV-2 detection. Ongoing data collection and data sharing are needed to improve the precision of the estimated NPV, and here we report interim results to inform infection control strategies in light of a second wave threatening this essential workforce.

Published
2021
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13. Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan.

Author

Debban CL, Ambalavanan A, Ghosh A, Li Z, Buschur KL, Ma Y, George E, Pistenmaa C, Bertoni AG, Oelsner EC, Michos ED, Moraes TJ, Jacobs DR Jr, Christenson S, Bhatt SP, Kaner RJ, Simons E, Turvey SE, Vameghestahbanati M, Engert JC, Kirby M, Bourbeau J, Tan WC, Gabriel SB, Gupta N, Woodruff PG, Subbarao P, Ortega VE, Bleecker ER, Meyers DA, Rich SS, Hoffman EA, Barr RG, Cho MH, Bossé Y, Duan Q, Manichaikul A, and Smith BM

Abstract

Rationale Dysanapsis refers to a mismatch between airway tree caliber and lung size arising early in life. Dysanapsis assessed by computed tomography (CT) is evident by early adulthood and associated with chronic obstructive pulmonary disease (COPD) risk later in life. Objective By examining the genetic factors associated with CT-assessed dysanapsis, we aimed to elucidate its molecular underpinnings and physiological significance across the lifespan. Methods We performed a genome-wide association study (GWAS) of CT-assessed dysanapsis in 11,951 adults, including individuals from two population-based and two COPD-enriched studies. We applied colocalization analysis to integrate GWAS and gene expression data from whole blood and lung. Genetic variants associated with dysanapsis were combined into a genetic risk score that was applied to examine association with lung function in children from a population-based birth cohort (n=1,278) and adults from the UK Biobank (n=369,157). Measurements and Main Results CT-assessed dysanapsis was associated with genetic variants from 21 independent signals in 19 gene regions, implicating HHIP , DSP , and NPNT as potential molecular targets based on colocalization of their expression. Higher dysanapsis genetic risk score was associated with obstructive spirometry among 5 year old children and among adults in the 5th, 6th and 7th decades of life. Conclusions CT-assessed dysanapsis is associated with variation in genes previously implicated in lung development and dysanapsis genetic risk is associated with obstructive lung function from early life through older adulthood. Dysanapsis may represent an endo-phenotype link between the genetic variations associated with lung function and COPD.

Published
2024
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