127 results on '"Valton L"'
Search Results
2. La stimulation du nerf vague dans le traitement des épilepsies pharmacorésistantes : étude rétrospective bicentrique d’une cohorte de 101 patients implantés entre 1999 et 2010
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Champeaux, C., Marchal, C., and Valton, L.
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- 2016
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3. Bilateral Wada test: Amobarbital or propofol?
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Curot, J., Denuelle, M., Busigny, T., Barragan-Jason, G., Kany, M., Tall, P., Marlat, F., Fabre, N., and Valton, L.
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- 2014
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4. Predictive factors of postoperative outcome in the elderly after resective epilepsy surgery
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Thomas, B., primary, Aupy, J., additional, Penchet, G., additional, De Montaudouin, M., additional, Bartolomei, F., additional, Biraben, A., additional, Catenoix, H., additional, Chassoux, F., additional, Dupont, S., additional, Valton, L., additional, Michel, V., additional, and Marchal, C., additional
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- 2022
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5. HP26: Electrophysiological properties of electrical brain stimulations and their impact on neuronal activity during stereoelectroencephalography in epilepsy
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Calvel, A., primary, Barbeau, E., additional, Sol, J.C., additional, Lotterie, J.A., additional, Guines, K., additional, Denuelle, M., additional, Bergaud, C., additional, Ali, M., additional, Valton, L., additional, and Curot, J., additional
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- 2022
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6. HP22: Daily evolution of brain connectivity during the pre-ictal period in intracranial recordings of epileptic patients
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Dallmer-Zerbe, I., primary, Kopal, J., additional, Pidnebesna, A., additional, Curot, J., additional, Denuelle, M., additional, Sol, J.C., additional, Valton, L., additional, Barbeau, E.J., additional, and Hlinka, J., additional
- Published
- 2022
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- View/download PDF
7. Effect of meditation on intracerebral EEG in a patient with temporal lobe epilepsy: A case report
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Delorme, A., primary, Grandchamp, R., additional, Curot, J., additional, Barragan-Jason, G., additional, Denuelle, M., additional, Sol, J.C., additional, and Valton, L., additional
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- 2021
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8. Évaluation médicoéconomique de la chirurgie des épilepsies partielles pharmacorésistantes de l’adulte: Résultats à trois ans d’une étude prospective multicentrique française
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Picot, M.-C., Jaussent, A., Kahane, P., Crespel, A., Gélisse, P., Hirsch, E., Derambure, P., Dupont, S., Landré, E., Chassoux, F., Valton, L., Vignal, J.-P., Marchal, C., Rougier, A., Lamy, C., Semah, F., Biraben, A., Arzimanoglou, A., Petit, J., Thomas, P., Neveu, D., and Ryvlin, P.
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- 2008
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9. Évaluation médico-économique de la chirurgie des épilepsies partielles pharmaco-résistantes de l’adulte. Étude coût-efficacité - Résultats préliminaires
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Picot, M.-C., Neveu, D., Kahane, P., Crespel, A., Gélisse, P., Hirsch, E., Derambure, P., Dupont, S., Landré, E., Chassoux, F., Valton, L., Vignal, J.-P., Marchal, C., Rougier, A., Lamy, C., Semah, F., Biraben, A., Arzimanoglou, A., Petit, J., Thomas, P., Dujols, P., and Ryvlin, P.
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- 2004
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10. Quelle est la place du bilan neuropsychologique dans la prise en charge des patients souffrant d’une épilepsie partielle pharmaco-résistante ?
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Valton, L. and Mascott, C.-R.
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- 2004
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11. Quelle est la place du test de Wada dans le bilan préchirurgical des épilepsies pharmaco-résistantes chez l’adulte ?
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Valton, L. and Mascott, C.-R.
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- 2004
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12. Atteinte rénale au cours de la sclérose tubéreuse de Bourneville (STB) : données d’une cohorte régionale
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Tosi, P.-O., primary, Delchier, M.C., additional, Valton, L., additional, Mazereeuw-Hautier, J., additional, Prévot, G., additional, Faguer, S., additional, and Chauveau, D., additional
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- 2019
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13. Cerebral microembolism in patients with stroke or transient ischaemic attack as a risk factor for early recurrence
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Valton, L, Larrue, V, Le Traon, A Pavy, and Geraud, G
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- 1997
14. Troubles de l’humeur et chirurgie de l’épilepsie : une revue de la littérature
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Yrondi, A., primary, Arbus, C., additional, Valton, L., additional, and Schmitt, L., additional
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- 2017
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15. Prise en charge des états de mal épileptiques généralisés de l’adulte en France en 2010
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Valton, L. and Aranda, A.
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- 2010
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16. Traitement médical pour le sujet âgé épileptique
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Valton, L., primary
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- 2014
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17. Mieux comprendre la surmortalité chez les patients atteints d’épilepsie : les actions du réseau national sentinelle mortalité épilepsie (RSME)
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Picot, M.-C., primary, Faucanié, M., additional, Andrès, J., additional, Larquier, B., additional, Valton, L., additional, Hirsch, E., additional, and Biraben, A., additional
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- 2013
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18. CLIN-SYMPTOM MANAGEMENT/QUALITY OF LIFE
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Habets, E. J., primary, Taphoorn, M. J., additional, Nederend, S., additional, Klein, M., additional, Delgadillo, D., additional, Hoang-Xuan, K., additional, Bottomley, A., additional, Allgeier, A., additional, Seute, T., additional, Gijtenbeek, A. M., additional, De Gans, J., additional, Enting, R. H., additional, Tijssen, C. C., additional, Van den Bent, M. J., additional, Reijneveld, J. C., additional, Xu, H., additional, Halbert, K., additional, Bliss, R., additional, Trusheim, J., additional, Hunt, M. A., additional, Bunevicius, A., additional, Tamasauskas, S., additional, Tamasauskas, A., additional, Deltuva, V., additional, Field, K. M., additional, Guyatt, N., additional, Fleet, M., additional, Rosenthal, M. A., additional, Drummond, K. J., additional, Oliver, H., additional, Tobias, M., additional, Eva, V., additional, Matthias, S., additional, Johannes, S., additional, Oliver, S., additional, Christian, T. J., additional, Dietmar, K., additional, Gabriele, S., additional, Thomas, R., additional, Nikkhah, G., additional, Uwe, S., additional, Markus, L., additional, Michael, W., additional, Manfred, W., additional, Strowd, R. E., additional, Swett, K., additional, Harmon, M., additional, Pop-Vicas, A., additional, Chan, M., additional, Tatter, S. B., additional, Ellis, T. L., additional, Blevins, M., additional, High, K., additional, Lesser, G. J., additional, Benouaich-Amiel, A., additional, Taillandier, L., additional, Vercueil, L., additional, Valton, L., additional, Szurhaj, W., additional, Idbaih, A., additional, Delattre, J.-Y., additional, Loiseau, H., additional, Klein, I., additional, Block, V., additional, Ramirez, C., additional, Laigle-Donadey, F., additional, Le Rhun, E., additional, Harrison, C., additional, Van Horn, A., additional, Sapienza, C., additional, Schlimper, C., additional, Schlag, H., additional, Weber, F., additional, Acquaye, A. A., additional, Gilbert, M. R., additional, Armstrong, T. S., additional, Vera-Bolanos, E., additional, Walbert, T., additional, Elizabeth, V.-B., additional, Gilbert, M., additional, Affronti, M. L., additional, Woodring, S., additional, Allen, K., additional, Herndon, J. E., additional, McSherry, F., additional, Peters, K. B., additional, Friedman, H. S., additional, Desjardins, A., additional, Freeman, W., additional, Cheshire, S., additional, Cone, C., additional, Kalinowski, K. H., additional, Kim, J.-Y., additional, Lay, H. H., additional, Poillucci, V., additional, Southerland, C., additional, Tetterton, J., additional, Kirkpatrick, J., additional, Vredenburgh, J. J., additional, Edelstein, K., additional, Coate, L., additional, Mason, W. P., additional, Jewitt, N. C., additional, Massey, C., additional, Devins, G. M., additional, Lin, L., additional, Chiang, H.-H., additional, Cahill, J. E., additional, Amidei, C. M., additional, Lovely, M., additional, Page, M. D., additional, Mogensen, K., additional, Arzbaecher, J., additional, Lupica, K., additional, Maher, M. E., additional, Duong, H. T., additional, Kelly, D. F., additional, Gning, I., additional, Wefel, J. S., additional, Mendoza, T. R., additional, Cleeland, C. S., additional, Guthikonda, B., additional, Thakur, J. D., additional, Banerjee, A., additional, Shorter, C., additional, Sonig, A., additional, Khan, I. S., additional, Gardner, G. L., additional, Nanda, A., additional, Reddy, K., additional, Gaspar, L., additional, Kavanagh, B., additional, Waziri, A., additional, Chen, C., additional, Boele, F., additional, Hoeben, W., additional, Hilverda, K., additional, Lenting, J., additional, Calis, A.-L., additional, Sizoo, E., additional, Collette, E., additional, Heimans, J., additional, Postma, T., additional, Taphoorn, M., additional, and Reijneveld, J., additional
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- 2012
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19. Comment optimiser le traitement anti-épileptique pour réduire les troubles cognitifs ?
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Valton, L., primary
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- 2012
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20. Tractographie des radiations optiques : étude comparative de la distance pôle temporal-boucle de Meyer et validation de la technique en utilisant le modèle lésionnel de la chirurgie de l’épilepsie temporale
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Borius, P.-Y., primary, Valton, L., additional, Sol, J.-C., additional, Lotterie, J.-A., additional, Denuelle, M., additional, Catalaa, I., additional, Berot, A., additional, and Berry, I., additional
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- 2010
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21. Étude prospective sur EME ; résultats en préhospitalier
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Foucart, G., primary, Aranda, A., additional, Grolleau, S., additional, Palancade, R., additional, Valton, L., additional, and Ducassé, J.-L., additional
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- 2009
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22. Étude coût–efficacité de la chirurgie de l’épilepsie dans une cohorte adulte de patients présentant une épilepsie partielle pharmacorésistante
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Picot, M.-C., primary, Jaussent, A., additional, Kahane, P., additional, Crespel, A., additional, Hirsch, E., additional, Derambure, P., additional, Dupont, S., additional, Landré, E., additional, Chassoux, F., additional, Valton, L., additional, Vignal, J.-P., additional, Arzimanoglou, A., additional, Marchal, C., additional, Rougier, A., additional, Lamy, C., additional, Semah, F., additional, Biraben, A., additional, Neveu, D., additional, Dujols, P., additional, and Ryvlin, P., additional
- Published
- 2008
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23. Traitement de l’état de mal épileptique : appliquons les conférences de consensus !
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Foucart, G., primary, Aranda, A., additional, Palancade, R., additional, Bellard, C., additional, Valton, L., additional, and Ducassé, J.L., additional
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- 2008
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24. Évaluation des connaissances et des pratiques sur la prise en charge en urgences de l'état de mal épileptique
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Foucart, G., primary, Aranda, A., additional, Bounes, V., additional, Valton, L., additional, and Ducassé, J.-L., additional
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- 2007
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25. A - 3 Évaluation des connaissances et des pratiques sur la prise en charge en urgence de l’état de mal épileptique généralisé de l’adulte
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Aranda, A., primary, Foucard, G., additional, Ducassé, J.-L., additional, and Valton, L., additional
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- 2007
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26. Vascularite cérébrale cryoglobulinémique et syndrome de Kojevnikov
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Gaudin C, C., primary, Meliani, P., additional, Sailler, L., additional, Madaule, S., additional, Valton, L., additional, Astudillo, L., additional, and Arlet, P., additional
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- 2003
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27. Hamartomes hypothalamiques : aspects électro-cliniques
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Hein, C., primary, Valton, L., additional, Lotterie, J.A., additional, Kany, M., additional, Tiberge, M., additional, and Geraud, G., additional
- Published
- 2002
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28. Etats de mal précipités par un traitement inadapté en cas d'épilepsie généralisée idiopathique : Données vidéo EEG
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Valton, L., primary and Thomas, P., additional
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- 2002
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29. Evaluation of new online automated embolic signal detection algorithm, including comparison with panel of international experts.
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Cullinane, M, Reid, G, Dittrich, R, Kaposzta, Z, Ackerstaff, R, Babikian, V, Droste, D W, Grossett, D, Siebler, M, Valton, L, and Markus, H S
- Published
- 2000
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30. Microembolic signals and risk of early recurrence in patients with stroke or transient ischemic attack.
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Valton, L, Larrue, V, le Traon, A P, Massabuau, P, and Géraud, G
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- 1998
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31. Asymptomatic cerebral embolic signals in patients with carotid stenosis. Correlation with appearance of plaque ulceration on angiography.
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Valton, L, Larrue, V, Arrué, P, Géraud, G, and Bès, A
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- 1995
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32. Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals
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Joshua E. Motelow, Gundula Povysil, Ryan S. Dhindsa, Kate E. Stanley, Andrew S. Al- len, Yen-Chen Anne Feng, Daniel P. Howrigan, Liam E. Abbott, Ka- therine Tashman, Felecia Cerrato, Caroline Cusick, Tarjinder Singh, Henrike Heyne, Andrea E. Byrnes, Claire Churchhouse, Nick Watts, Matthew Solomonson, Dennis Lal, Namrata Gupta, Benjamin M. Neale, Gianpiero L. Cavalleri, Patrick Cossette, Chris Cotsapas, Peter De Jonghe, Tracy Dixon-Salazar, Renzo Guerrini, Hakon Hakonarson, Erin L. Heinzen, Ingo Helbig, Patrick Kwan, Anthony G. Marson, Slave ? Petrovski, Sitharthan Kamalakaran, Sanjay M. Sisodiya, Randy Stewart, Sarah Weckhuysen, Chantal Depondt, Dennis J. Dlugos, Ingrid E. Scheffer, Pasquale Striano, Catharine Freyer, Roland Krause, Patrick May, Kevin McKenna, Brigid M. Regan, Caitlin A. Bennett, Costin Leu, Stephanie L. Leech, Terence J. O'Brien, Marian Todaro, Hannah Stamberger, Danielle M. Andrade, Quratulain Zulfiqar Ali, Tara R. Sadoway, Heinz Krestel, Andre ? Schaller, Savvas S. Papacostas, Ioanna Kou- siappa, George A. Tanteles, Yiolanda Christou, Katalin Sterbova ?, Marke ? ta Vlckova ?, Lucie Sedlackova, Petra Lassuthova ?, Karl Martin Klein, Felix Rosenow, Philipp S. Reif, Susanne Knake, Bernd A. Neubauer, Friedrich Zimprich, Martha Feucht, Eva M. Reinthaler, Wolfram S. Kunz, Ga ?bor Zsurka, Rainer Surges, Tobias Baumgart- ner, Randi von Wrede, Manuela Pendziwiat, Hiltrud Muhle, An- nika Rademacher, Andreas van Baalen, Sarah von Spiczak, Ulrich Stephani, Zaid Afawi, Amos D. Korczyn, Moien Kanaan, Christina Canavati, Gerhard Kurlemann, Karen Mu ?ller-Schlu ?ter, Gerhard Kluger, Martin Ha ?usler, Ilan Blatt, Johannes R. Lemke, Ilona Krey, Yvonne G. Weber, Stefan Wolking, Felicitas Becker, Stephan Lauxmann, Christian Boßelmann, Josua Kegele, Christian Hengs- bach, Sarah Rau, Bernhard J. Steinhoff, Andreas Schulze-Bonhage, IngoBorggra ?fe, ChristophJ.Schankin, SusanneSchubert-Bast, Herbert Schreiber, Thomas Mayer, Rudolf Korinthenberg, Knut Brockmann, Markus Wolff, Dieter Dennig, Rene Madeleyn, Reetta Ka ?lvia ?inen, Anni Saarela, Oskari Timonen, Tarja Linnankivi, Anna-Elina Lehesjoki, Sylvain Rheims, Gaetan Lesca, Philippe Ryvlin, Louis Maillard, Luc Valton, Philippe Derambure, Fabrice Bartolomei, Edouard Hirsch, Ve ?ronique Michel, Francine Chas- soux, Mark I. Rees, Seo-Kyung Chung, William O. Pickrell, Robert Powell, Mark D. Baker, Beata Fonferko-Shadrach, Charlotte Law- thom, Joseph Anderson, Natascha Schneider, Simona Balestrini, Sara Zagaglia, Vera Braatz, Michael R. Johnson, Pauls Auce, Graeme J. Sills, Larry W. Baum, Pak C. Sham, Stacey S. Cherny, Colin H.T. Lui, Norman Delanty, Colin P. Doherty, Arif Shukralla, Hany El-Naggar, Peter Widdess-Walsh, Nina Barisic, Laura 12 The American Journal of Human Genetics 108, 1-18, June 3, 2021 Please cite this article in press as: Epi25 Collaborative, Sub-genic intolerance, ClinVar, the epilepsies: A whole-exome sequencing study of 29, 165 individuals, The American Journal of Human Genetics (2021), https://doi.org/10.1016/j.ajhg.2021.04.009 Canafoglia, Silvana Franceschetti, Barbara Castellotti, Tiziana Granata, Francesca Ragona, Federico Zara, Michele Iacomino, An- tonella Riva, Francesca Madia, Maria Stella Vari, Vincenzo Salpie- tro, Marcello Scala, Maria Margherita Mancardi, Lino Nobili, Elisa- betta Amadori, Thea Giacomini, Francesca Bisulli, Tommaso Pippucci, Laura Licchetta, Raffaella Minardi, Paolo Tinuper, Lor- enzo Muccioli, Barbara Mostacci, Antonio Gambardella, Angelo Labate, Grazia Annesi, Lorella Manna, Monica Gagliardi, Elena Parrini, Davide Mei, Annalisa Vetro, Claudia Bianchini, Martino Montomoli, Viola Doccini, Carmen Barba, Shinichi Hirose, At- sushi Ishii, Toshimitsu Suzuki, Yushi Inoue, Kazuhiro Yamakawa, Ahmad Beydoun, Wassim Nasreddine, Nathalie Khoueiry Zgheib, Birute Tumiene, Algirdas Utkus, Lynette G. Sadleir, Chontelle King, S. Hande Caglayan, Mutluay Arslan, Zuhal Yap?c?, P?nar To- paloglu, Bulent Kara, Uluc Yis, Dilsad Turkdogan, Asl? Gun- dogdu-Eken, Nerses Bebek, Meng-Han Tsai, Chen-Jui Ho, Chih- Hsiang Lin, Kuang-Lin Lin, I-Jun Chou, Annapurna Poduri, Beth R. Shiedley, Catherine Shain, Jeffrey L. Noebels, Alicia Goldman, Robyn M. Busch, Lara Jehi, Imad M. Najm, Lisa Ferguson, Jean Khoury, Tracy A. Glauser, Peggy O. Clark, Russell J. Buono, Thomas N. Ferraro, Michael R. Sperling, Warren Lo, Michael Privitera, Jac- queline A. French, Steven Schachter, Ruben I. Kuzniecky, Orrin Devinsky, Manu Hegde, David A. Greenberg, Colin A. Ellis, Ethan Goldberg, Katherine L. Helbig, Mahgenn Cosico, Priya Vaidis- waran, Eryn Fitch, Samuel F. Berkovic, Holger Lerche, Daniel H. Lowenstein, David B. Goldstein., Motelow J.E., Povysil G., Dhindsa R.S., Stanley K.E., Allen A.S., Feng Y.-C.A., Howrigan D.P., Abbott L.E., Tashman K., Cerrato F., Cusick C., Singh T., Heyne H., Byrnes A.E., Churchhouse C., Watts N., Solomonson M., Lal D., Gupta N., Neale B.M., Cavalleri G.L., Cossette P., Cotsapas C., De Jonghe P., Dixon-Salazar T., Guerrini R., Hakonarson H., Heinzen E.L., Helbig I., Kwan P., Marson A.G., Petrovski S., Kamalakaran S., Sisodiya S.M., Stewart R., Weckhuysen S., Depondt C., Dlugos D.J., Scheffer I.E., Striano P., Freyer C., Krause R., May P., McKenna K., Regan B.M., Bennett C.A., Leu C., Leech S.L., O'Brien T.J., Todaro M., Stamberger H., Andrade D.M., Ali Q.Z., Sadoway T.R., Krestel H., Schaller A., Papacostas S.S., Kousiappa I., Tanteles G.A., Christou Y., Sterbova K., Vlckova M., Sedlackova L., Lassuthova P., Klein K.M., Rosenow F., Reif P.S., Knake S., Neubauer B.A., Zimprich F., Feucht M., Reinthaler E.M., Kunz W.S., Zsurka G., Surges R., Baumgartner T., von Wrede R., Pendziwiat M., Muhle H., Rademacher A., van Baalen A., von Spiczak S., Stephani U., Afawi Z., Korczyn A.D., Kanaan M., Canavati C., Kurlemann G., Muller-Schluter K., Kluger G., Hausler M., Blatt I., Lemke J.R., Krey I., Weber Y.G., Wolking S., Becker F., Lauxmann S., Bosselmann C., Kegele J., Hengsbach C., Rau S., Steinhoff B.J., Schulze-Bonhage A., Borggrafe I., Schankin C.J., Schubert-Bast S., Schreiber H., Mayer T., Korinthenberg R., Brockmann K., Wolff M., Dennig D., Madeleyn R., Kalviainen R., Saarela A., Timonen O., Linnankivi T., Lehesjoki A.-E., Rheims S., Lesca G., Ryvlin P., Maillard L., Valton L., Derambure P., Bartolomei F., Hirsch E., Michel V., Chassoux F., Rees M.I., Chung S.-K., Pickrell W.O., Powell R., Baker M.D., Fonferko-Shadrach B., Lawthom C., Anderson J., Schneider N., Balestrini S., Zagaglia S., Braatz V., Johnson M.R., Auce P., Sills G.J., Baum L.W., Sham P.C., Cherny S.S., Lui C.H.T., Delanty N., Doherty C.P., Shukralla A., El-Naggar H., Widdess-Walsh P., Barisic N., Canafoglia L., Franceschetti S., Castellotti B., Granata T., Ragona F., Zara F., Iacomino M., Riva A., Madia F., Vari M.S., Salpietro V., Scala M., Mancardi M.M., Nobili L., Amadori E., Giacomini T., Bisulli F., Pippucci T., Licchetta L., Minardi R., Tinuper P., Muccioli L., Mostacci B., Gambardella A., Labate A., Annesi G., Manna L., Gagliardi M., Parrini E., Mei D., Vetro A., Bianchini C., Montomoli M., Doccini V., Barba C., Hirose S., Ishii A., Suzuki T., Inoue Y., Yamakawa K., Beydoun A., Nasreddine W., Khoueiry Zgheib N., Tumiene B., Utkus A., Sadleir L.G., King C., Caglayan S.H., Arslan M., Yapici Z., Topaloglu P., Kara B., Yis U., Turkdogan D., Gundogdu-Eken A., Bebek N., Tsai M.-H., Ho C.-J., Lin C.-H., Lin K.-L., Chou I.-J., Poduri A., Shiedley B.R., Shain C., Noebels J.L., Goldman A., Busch R.M., Jehi L., Najm I.M., Ferguson L., Khoury J., Glauser T.A., Clark P.O., Buono R.J., Ferraro T.N., Sperling M.R., Lo W., Privitera M., French J.A., Schachter S., Kuzniecky R.I., Devinsky O., Hegde M., Greenberg D.A., Ellis C.A., Goldberg E., Helbig K.L., Cosico M., Vaidiswaran P., Fitch E., Berkovic S.F., Lerche H., Lowenstein D.H., Goldstein D.B., Epi25 Collaborative, Institut de Neurosciences des Systèmes (INS), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
0301 basic medicine ,focal epilepsy ,Whole Exome Sequencing ,Cohort Studies ,Epilepsy ,0302 clinical medicine ,Genetic Marker ,Missense mutation ,Exome ,whole-exome sequencing ,generalized epilepsy ,ComputingMilieux_MISCELLANEOUS ,Genetics (clinical) ,Exome sequencing ,seizures ,Genetics ,ClinVar ,Phenotype ,epileptic encephalopathy ,Epi25 ,intolerance ,Case-Control Studie ,Human ,Genetic Markers ,seizure ,Disease Association ,Biology ,Article ,03 medical and health sciences ,Exome Sequencing ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Generalized epilepsy ,Gene ,Louvain ,[SCCO.NEUR]Cognitive science/Neuroscience ,Correction ,Genetic Variation ,medicine.disease ,epilepsy ,Human genetics ,030104 developmental biology ,Case-Control Studies ,Human medicine ,Cohort Studie ,Genetic generalized epilepsy ,030217 neurology & neurosurgery - Abstract
Summary Both mild and severe epilepsies are influenced by variants in the same genes, yet an explanation for the resulting phenotypic variation is unknown. As part of the ongoing Epi25 Collaboration, we performed a whole-exome sequencing analysis of 13,487 epilepsy-affected individuals and 15,678 control individuals. While prior Epi25 studies focused on gene-based collapsing analyses, we asked how the pattern of variation within genes differs by epilepsy type. Specifically, we compared the genetic architectures of severe developmental and epileptic encephalopathies (DEEs) and two generally less severe epilepsies, genetic generalized epilepsy and non-acquired focal epilepsy (NAFE). Our gene-based rare variant collapsing analysis used geographic ancestry-based clustering that included broader ancestries than previously possible and revealed novel associations. Using the missense intolerance ratio (MTR), we found that variants in DEE-affected individuals are in significantly more intolerant genic sub-regions than those in NAFE-affected individuals. Only previously reported pathogenic variants absent in available genomic datasets showed a significant burden in epilepsy-affected individuals compared with control individuals, and the ultra-rare pathogenic variants associated with DEE were located in more intolerant genic sub-regions than variants associated with non-DEE epilepsies. MTR filtering improved the yield of ultra-rare pathogenic variants in affected individuals compared with control individuals. Finally, analysis of variants in genes without a disease association revealed a significant burden of loss-of-function variants in the genes most intolerant to such variation, indicating additional epilepsy-risk genes yet to be discovered. Taken together, our study suggests that genic and sub-genic intolerance are critical characteristics for interpreting the effects of variation in genes that influence epilepsy.
- Published
- 2021
33. Mise en abyme of post-traumatic stress disorder and infantile regression revealed by intracranial electrical stimulation in epilepsy.
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Robin A, Barbeau EJ, Denuelle M, Guillen A, De Barros A, Sol JC, Mirabel H, Lotterie JA, Yrondi A, Rulquin F, Valton L, and Curot J
- Abstract
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2024
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34. No major effect of dopamine receptor 1/5 antagonist SCH-23390 on epileptic activity in the Tg2576 mouse model of amyloidosis.
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B Szabo A, Sayegh F, Gauzin S, Lejards C, Guiard B, Valton L, Verret L, Rampon C, and Dahan L
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- Mice, Animals, Dopamine Antagonists pharmacology, Receptors, Dopamine D2 metabolism, Benzazepines pharmacology, Benzazepines therapeutic use, Receptors, Dopamine D1 metabolism, Disease Models, Animal, Alzheimer Disease drug therapy, Epilepsy drug therapy, Amyloidosis drug therapy
- Abstract
The excitation-inhibition imbalance manifesting as epileptic activities in Alzheimer's disease is gaining more and more attention, and several potentially involved cellular and molecular pathways are currently under investigation. Based on in vitro studies, dopamine D1-type receptors in the anterior cingulate cortex and the hippocampus have been proposed to participate in this peculiar co-morbidity in mouse models of amyloidosis. Here, we tested the implication of dopaminergic transmission in vivo in the Tg2576 mouse model of Alzheimer's disease by monitoring epileptic activities via intracranial EEG before and after treatment with dopamine antagonists. Our results show that neither the D1-like dopamine receptor antagonist SCH23390 nor the D2-like dopamine receptor antagonist haloperidol reduces the frequency of epileptic activities. While requiring further investigation, our results indicate that on a systemic level, dopamine receptors are not significantly contributing to epilepsy observed in vivo in this mouse model of Alzheimer's disease., (© 2024 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
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- 2024
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35. [Evaluation of the relevance of the pharmaceutical educational interview on the knowledge and satisfaction of patients who received a vagus nerve neurostimulator implantation].
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Marqueyssat GS, Valton L, Civade E, and Laborde C
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- Humans, Patient Satisfaction, Vagus Nerve, Pharmaceutical Preparations, Treatment Outcome, Retrospective Studies, Vagus Nerve Stimulation adverse effects, Vagus Nerve Stimulation methods, Drug Resistant Epilepsy etiology, Drug Resistant Epilepsy therapy, Drug-Related Side Effects and Adverse Reactions
- Abstract
Introduction: Vagal neurostimulation (VNS) medical devices (MDs) are used to treat drug-resistant epilepsy. Using a magnet, the patient can activate on the stimulations in order to stop a seizure or interrupt the adverse effects (AEs) of the device. The objective is to evaluate the improvement of the patients' knowledge about the VNS following a pharmaceutical educational interview (PEI) as well as their satisfaction., Materials and Methods: The pharmaceutical educational interview regarding drugs and DMs was performed by the clinical pharmacist at the patient's bed after VNS implantation. A questionnaire about VNS devices (operation, adverse effects, recommendations) and assessing knowledge was submitted to patients before and after the PEI. Satisfaction was assessed by the Likert scale., Results: From March 2020 to August 2021, 18 implanted patients were included in the study. In 78% of cases (14/18), the total number of good responses after PEI increased. The mean good response was significantly increased from 16.11/25 (64%) before PEI to 22.33/25 (89%) after PEI (P-value<0.01). The maximum satisfaction score (4/4) was given in 71% of the items., Discussion-Conclusion: The results support the relevance of PEI. Patients feel a need for information and consider the interview useful. An improvement in knowledge was observed, which allows us to hope for an optimization of the effectiveness of the device, in particular, a reduction in seizures and AE. This study shows the feasibility and the interest of the development of clinical pharmacy applied to medical devices in complementarity with the expertise on drugs., (Copyright © 2023 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.)
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- 2024
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36. Large-scale network dynamics underlying the first few hundred milliseconds after stimulus presentation: An investigation of visual recognition memory using iEEG.
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Kopal J, Hlinka J, Despouy E, Valton L, Denuelle M, Sol JC, Curot J, and Barbeau EJ
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- Humans, Memory, Recognition, Psychology, Frontal Lobe, Magnetic Resonance Imaging, Brain Mapping methods, Brain diagnostic imaging
- Abstract
Recognition memory is the ability to recognize previously encountered objects. Even this relatively simple, yet extremely fast, ability requires the coordinated activity of large-scale brain networks. However, little is known about the sub-second dynamics of these networks. The majority of current studies into large-scale network dynamics is primarily based on imaging techniques suffering from either poor temporal or spatial resolution. We investigated the dynamics of large-scale functional brain networks underlying recognition memory at the millisecond scale. Specifically, we analyzed dynamic effective connectivity from intracranial electroencephalography while epileptic subjects (n = 18) performed a fast visual recognition memory task. Our data-driven investigation using Granger causality and the analysis of communities with the Louvain algorithm spotlighted a dynamic interplay of two large-scale networks associated with successful recognition. The first network involved the right visual ventral stream and bilateral frontal regions. It was characterized by early, predominantly bottom-up information flow peaking at 115 ms. It was followed by the involvement of another network with predominantly top-down connectivity peaking at 220 ms, mainly in the left anterior hemisphere. The transition between these two networks was associated with changes in network topology, evolving from a more segregated to a more integrated state. These results highlight that distinct large-scale brain networks involved in visual recognition memory unfold early and quickly, within the first 300 ms after stimulus onset. Our study extends the current understanding of the rapid network changes during rapid cognitive processes., (© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
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- 2023
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37. Radiosurgical Corpus Callosotomy for Intractable Epilepsy: Retrospective Long-Term Safety and Efficacy Assessment in 19 Patients an Review of the Literature.
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Hamdi H, Boissonneau S, Valton L, McGonigal A, Bartolomei F, and Regis J
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- Humans, Retrospective Studies, Treatment Outcome, Corpus Callosum diagnostic imaging, Corpus Callosum surgery, Magnetic Resonance Imaging, Seizures surgery, Syncope surgery, Drug Resistant Epilepsy surgery, Radiosurgery methods
- Abstract
Background: Some patients suffering from intractable epileptic seizures, particularly drop attacks (DAs), are nonremediable by curative techniques. Palliative procedure carries a significant rate of surgical and neurological complications., Objective: To propose evaluation of safety and efficacy of Gamma Knife corpus callosotomy (GK-CC) as an alternative to microsurgical corpus callosotomy., Methods: This study included retrospective analysis of 19 patients who underwent GK-CC between 2005 and 2017., Results: Of the 19 patients, 13 (68%) had improvement in seizure control and 6 had no significant improvement. Of the 13/19 (68%) with improvement in seizures, 3 (16%) became completely seizure-free, 2 (11%) became free of DA and generalized tonic-clonic but with residual other seizures, 3 (16%) became free of DA only, and 5 (26%) had >50% reduction in frequency of all seizure types. In the 6 (31%) patients with no appreciable improvement, there were residual untreated commissural fibers and incomplete callosotomy rather than failure of Gamma Knife to disconnect. Seven patients showed a transient mild complication (37% of patients, 33% of the procedures). No permanent complication or neurological consequence was observed during the clinical and radiological workup with a mean of 89 (42-181) months, except 1 patient who had no improvement of epilepsy and then aggravation of the pre-existing cognitive and walking difficulties (Lennox-Gastaut). The median time of improvement after GK-CC was 3 (1-6) months., Conclusion: Gamma Knife callosotomy is safe and accurate with comparable efficacy to open callosotomy in this cohort of patients with intractable epilepsy suffering from severe drop attacks., (Copyright © Congress of Neurological Surgeons 2023. All rights reserved.)
- Published
- 2023
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38. Early identification of seizure freedom with medical treatment in patients with mesial temporal lobe epilepsy and hippocampal sclerosis.
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Cheval M, Houot M, Chastan N, Szurhaj W, Marchal C, Catenoix H, Valton L, Gavaret M, Herlin B, Biraben A, Lagarde S, Mazzola L, Minotti L, Maillard L, and Dupont S
- Subjects
- Humans, Retrospective Studies, Sclerosis pathology, Hippocampus pathology, Electroencephalography, Freedom, Epilepsy, Temporal Lobe complications, Epilepsy, Temporal Lobe drug therapy, Epilepsy, Temporal Lobe pathology, Hippocampal Sclerosis
- Abstract
Background: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is usually associated with a poor response to antiseizure medications. We focused on MTLE-HS patients who were seizure free on medication to: (1) determine the clinical factors associated with seizure freedom and (2) develop a machine-learning classifier to better earlier identify those patients., Methods: We performed a retrospective, multicentric study comparing 64 medically treated seizure-free MTLE-HS patients with 200 surgically treated drug-resistant MTLE-HS patients. First, we collected medical history and seizure semiology data. Then, we developed a machine-learning classifier based on clinical data., Results: Medically treated seizure-free MTLE-HS patients were seizure-free for at least 2 years, and for a median time of 7 years at last follow-up. Compared to drug-resistant MTLE-HS patients, they exhibited: an older age at epilepsy onset (22.5 vs 8.0 years, p < 0.001), a lesser rate of: febrile seizures (39.0% vs 57.5%, p = 0.035), focal aware seizures (previously referred to as aura)(56.7% vs 90.0%, p < 0.001), autonomic focal aware seizures in presence of focal aware seizure (17.6% vs 59.4%, p < 0.001), dystonic posturing of the limbs (9.8% vs 47.0%, p < 0.001), gestural (27.4% vs 94.0%, p < 0.001), oro-alimentary (32.3% vs 75.5%, p < 0.001) or verbal automatisms (12.9% vs 36.0%, p = 0.001). The classifier had a positive predictive value of 0.889, a sensitivity of 0.727, a specificity of 0.962, a negative predictive value of 0.893., Conclusions: Medically treated seizure-free MTLE-HS patients exhibit a distinct clinical profile. A classifier built with readily available clinical data can identify them accurately with excellent positive predictive value. This may help to individualize the management of MTLE-HS patients according to their expected pharmacosensitivity., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
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- 2023
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39. Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease - the influence of sleep and noradrenergic transmission.
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B Szabo A, Cattaud V, Bezzina C, Dard RF, Sayegh F, Gauzin S, Lejards C, Valton L, Rampon C, Verret L, and Dahan L
- Subjects
- Mice, Animals, Mice, Transgenic, Sleep physiology, Disease Models, Animal, Sleep, REM, Alzheimer Disease pathology, Epilepsy
- Abstract
The link between Alzheimer's disease (AD) and network hypersynchrony - manifesting as epileptic activities - received considerable attention in the past decade. However, several questions remain unanswered as to its mechanistic underpinnings. Therefore, our objectives were (1) to better characterise epileptic events in the Tg2576 mouse model throughout the sleep-wake cycle and disease progression via electrophysiological recordings and (2) to explore the involvement of noradrenergic transmission in this pathological hypersynchrony. Over and above confirming the previously described early presence and predominance of epileptic events during rapid-eye-movement (REM) sleep, we also show that these events do not worsen with age and are highly phase-locked to the section of the theta cycle during REM sleep where hippocampal pyramidal cells reach their highest firing probability. Finally, we reveal an antiepileptic mechanism of noradrenergic transmission via α1-adrenoreceptors that could explain the intriguing distribution of epileptic events over the sleep-wake cycle in this model, with potential therapeutic implications in the treatment of the epileptic events occurring in many AD patients., Competing Interests: Disclosure statement The authors have no actual or potential conflicts of interest., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
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40. Local neuronal excitation and global inhibition during epileptic fast ripples in humans.
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Curot J, Barbeau E, Despouy E, Denuelle M, Sol JC, Lotterie JA, Valton L, and Peyrache A
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- Humans, Brain pathology, Cerebral Cortex pathology, Brain Mapping, Electroencephalography, Epilepsy pathology, Brain Waves physiology
- Abstract
Understanding the neuronal basis of epileptic activity is a major challenge in neurology. Cellular integration into larger scale networks is all the more challenging. In the local field potential, interictal epileptic discharges can be associated with fast ripples (200-600 Hz), which are a promising marker of the epileptogenic zone. Yet, how neuronal populations in the epileptogenic zone and in healthy tissue are affected by fast ripples remain unclear. Here, we used a novel 'hybrid' macro-micro depth electrode in nine drug-resistant epileptic patients, combining classic depth recording of local field potentials (macro-contacts) and two or three tetrodes (four micro-wires bundled together) enabling up to 15 neurons in local circuits to be simultaneously recorded. We characterized neuronal responses (190 single units) with the timing of fast ripples (2233 fast ripples) on the same hybrid and other electrodes that target other brain regions. Micro-wire recordings reveal signals that are not visible on macro-contacts. While fast ripples detected on the closest macro-contact to the tetrodes were always associated with fast ripples on the tetrodes, 82% of fast ripples detected on tetrodes were associated with detectable fast ripples on the nearest macro-contact. Moreover, neuronal recordings were taken in and outside the epileptogenic zone of implanted epileptic subjects and they revealed an interlay of excitation and inhibition across anatomical scales. While fast ripples were associated with increased neuronal activity in very local circuits only, they were followed by inhibition in large-scale networks (beyond the epileptogenic zone, even in healthy cortex). Neuronal responses to fast ripples were homogeneous in local networks but differed across brain areas. Similarly, post-fast ripple inhibition varied across recording locations and subjects and was shorter than typical inter-fast ripple intervals, suggesting that this inhibition is a fundamental refractory process for the networks. These findings demonstrate that fast ripples engage local and global networks, including healthy tissue, and point to network features that pave the way for new diagnostic and therapeutic strategies. They also reveal how even localized pathological brain dynamics can affect a broad range of cognitive functions., (© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.)
- Published
- 2023
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41. Specific profiles of new-onset vs. non-inaugural status epilepticus: From diagnosis to 1-year outcome.
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Benaiteau M, Valton L, Gardy L, Denuelle M, Debs R, Wucher V, Rulquin F, Barbeau EJ, Bonneville F, Pariente J, and Curot J
- Abstract
While new-onset status epilepticus (NOSE) is a harbinger of chronic epilepsy, prospective medical data are sparse in terms of specifying whether the evolution of status epilepticus (SE) and seizure expression in NOSE resembles what occurs in patients who have already been diagnosed with epilepsy [non-inaugural SE (NISE)] in all aspects apart from its inaugural nature. The aim of this study was to compare the clinical, MRI, and EEG features that could distinguish NOSE from NISE. We conducted a prospective monocentric study in which all patients ≥18 years admitted for SE over a 6-month period were included. A total of 109 patients (63 NISE and 46 NOSE cases) were included. Despite similar modified Rankin scores before SE, several aspects of the clinical history distinguished NOSE from NISE patients. NOSE patients were older and frequently had neurological comorbidity and preexisting cognitive decline, but they had a similar prevalence of alcohol consumption to NISE patients. NOSE and NISE evolve in the same proportions as refractory SE (62.5% NOSE, 61% NISE) and share common features such as the same incidence (33% NOSE, 42% NISE, and p = 0.53) and volumes of peri-ictal abnormalities on MRI. However, in NOSE patients, we observed greater non-convulsive semiology (21.7% NOSE, 6% NISE, and p = 0.02), more periodic lateral discharges on EEG ( p = 0.004), later diagnosis, and higher severity according to the STESS and EMSE scales ( p < 0.0001). Mortality occurred in 32.6% of NOSE patients and 21% of NISE patients at 1 year ( p = 0.19), but with different causes of death occurring at different time points: more early deaths directly linked to SE at 1 month occurred in the NOSE group, while there were more remote deaths linked to causal brain lesions in the NISE group at final follow-up. In survivors, 43.6% of the NOSE cases developed into epilepsy. Despite acute causal brain lesions, the novelty related to its inaugural nature is still too often associated with a delay in diagnosing SE and a poorer outcome, which justifies the need to more clearly specify the various types of SE to constantly raise awareness among clinicians. These results highlight the relevance of including novelty-related criteria, clinical history, and temporality of occurrence in the nosology of SE., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Benaiteau, Valton, Gardy, Denuelle, Debs, Wucher, Rulquin, Barbeau, Bonneville, Pariente and Curot.)
- Published
- 2023
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42. Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy.
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B Szabo A, Cretin B, Gérard F, Curot J, J Barbeau E, Pariente J, Dahan L, and Valton L
- Abstract
The observation that a pathophysiological link might exist between Alzheimer's disease (AD) and epilepsy dates back to the identification of the first cases of the pathology itself and is now strongly supported by an ever-increasing mountain of literature. An overwhelming majority of data suggests not only a higher prevalence of epilepsy in Alzheimer's disease compared to healthy aging, but also that AD patients with a comorbid epileptic syndrome, even subclinical, have a steeper cognitive decline. Moreover, clinical and preclinical investigations have revealed a marked sleep-related increase in the frequency of epileptic activities. This characteristic might provide clues to the pathophysiological pathways underlying this comorbidity. Furthermore, the preferential sleep-related occurrence of epileptic events opens up the possibility that they might hasten cognitive decline by interfering with the delicately orchestrated synchrony of oscillatory activities implicated in sleep-related memory consolidation. Therefore, we scrutinized the literature for mechanisms that might promote sleep-related epileptic activity in AD and, possibly dementia onset in epilepsy, and we also aimed to determine to what degree and through which processes such events might alter the progression of AD. Finally, we discuss the implications for patient care and try to identify a common basis for methodological considerations for future research and clinical practice., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 B. Szabo, Cretin, Gérard, Curot, J. Barbeau, Pariente, Dahan and Valton.)
- Published
- 2022
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43. Interactions between antiseizure medications and contraception: A study about the knowledge of patients and their specialist physicians.
- Author
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Gosset A, Denuelle M, Valton L, Sommet A, Bénévent J, and Tremollières F
- Subjects
- Anticonvulsants adverse effects, Contraception methods, Contraceptive Agents therapeutic use, Female, Humans, Pregnancy, Epilepsy drug therapy, Physicians
- Abstract
Planning pregnancy is very important for women with epilepsy (WWE), because of the potential teratogenic effects and neurodevelopmental disorders of different antiseizure medications (ASMs). Nevertheless, contraception in WWE can be challenging due to the existence of drug interactions between ASMs and hormonal contraception. The aim of this study was to assess women's knowledge of potential interactions between their ASMs and contraceptive options. The second objective was to assess neurologist's knowledge of the potential interactions between ASMs and contraceptive methods. An anonymous online survey was proposed to reproductive-age WWE during consultation with their neurologist. Another online survey was proposed to neurologists. These surveys were performed through a French regional medical network. A total of 79 patients agreed to respond to the survey. Forty-nine women used lamotrigine alone or in combination, 15 used an enzyme-inducing ASM alone or in combination, 13 used non-enzyme-inducing ASM and 2 used both lamotrigine and an enzyme-inducing ASM. Half of the WWE had mistaken beliefs about interactions between their ASM and contraception. Among them, 35% of the women treated with an enzyme-inducing ASM were unaware of a potential decreased efficacy of hormonal contraception. Moreover, 51% of the women who were taking lamotrigine did not know that combined hormonal contraception might decrease the efficacy of their ASM. On the other hand, 64.5% of WWE without an enzyme-inducing ASM wrongly thought that their ASM can decrease their hormonal contraceptive efficacy. A total of 20 neurologists answered the online survey. It revealed specific gaps concerning interactions between ASM and contraceptives; in fact, 35% of answers concerning the identification of specific enzyme-inducing ASMs were wrong. This study therefore highlights the need for educational efforts for both WWE and their physicians regarding drug interactions between ASMs and hormonal contraceptives., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
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44. Hidden Objective Memory Deficits Behind Subjective Memory Complaints in Patients With Temporal Lobe Epilepsy.
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Lemesle B, Barbeau EJ, Milongo Rigal E, Denuelle M, Valton L, Pariente J, and Curot J
- Subjects
- Humans, Memory Disorders complications, Memory Disorders etiology, Mental Recall, Neuropsychological Tests, Epilepsy, Temporal Lobe complications, Epilepsy, Temporal Lobe diagnostic imaging, Epilepsy, Temporal Lobe pathology, Memory, Episodic
- Abstract
Background and Objectives: The aim of this work was to test the hypothesis that patients with temporal lobe epilepsy (TLE) with subjective initial memory complaints (not confirmed by an objective standard assessment) and various phenotypes also show objective very long-term memory deficit with accelerated long-term forgetting. We tested patients with TLE with 2 surprise memory tests after 3 weeks: the standard Free and Cued Selective Reminding Test (FCSRT) and Epireal, a new test specifically designed to capture more ecologic aspects of autobiographical memory., Methods: Forty-seven patients with TLE (12 with hippocampal sclerosis, 12 with amygdala enlargement, 11 with extensive lesions, 12 with normal MRI) who complained about their memory, but for whom the standard neuropsychological assessment did not reveal any memory impairment after a standard delay of 20 minutes, underwent 2 surprise memory tests after 3 weeks. They were compared to 35 healthy controls., Results: After 3 weeks, FCSRT and Epireal recall scores were significantly lower in patients than in controls ( p < 0.001). There was no significant correlation between FCSRT and Epireal scores ( p = 0.99). Seventy-six percent of patients with TLE had objective impairment on at least 1 of these very long-term memory tests, regardless of the existence and type of lesion or response to antiseizure medication. Easily applicable, Epireal had a higher effect size, detected deficits in 28% more patients, and is a useful addition to the standard workup., Discussion: Assessing long-term memory should be broadened to a wide spectrum of patients with TLE with a memory complaint, regardless of the epileptic syndrome, regardless of whether it is associated with a lesion. This could lead to rethinking TLE nosology associated with memory., (© 2021 American Academy of Neurology.)
- Published
- 2022
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45. Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy.
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Bourgeois-Vionnet J, Ryvlin P, Elsensohn MH, Michel V, Valton L, Derambure P, Frazzini V, Hirsch E, Maillard L, Bartolomei F, Biberon J, Petit J, Biraben A, Crespel A, Thomas P, Lemesle-Martin M, Convers P, Leclercq M, Boulogne S, Roy P, and Rheims S
- Subjects
- Anticonvulsants therapeutic use, Cross-Sectional Studies, Humans, Prospective Studies, Seizures drug therapy, Seizures epidemiology, Coffee, Epilepsies, Partial drug therapy, Epilepsies, Partial epidemiology
- Abstract
Objective: To assess the relation between coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy., Methods: Cross-sectional analysis of data collected in the SAVE study, which included patients with drug-resistant focal epilepsy during long-term EEG monitoring. Patients in whom both coffee consumption and data about seizure frequency, including focal to bilateral tonic-clonic seizures (FBTCS), were available were selected. Coffee consumption was collected using a standardized self-report questionnaire and classified into four groups: none, rare (from less than 1 cup/week to up 3 cups/week), moderate (from 4 cups/week to 3 cups/day), and high (more than 4 cups/day)., Results: Six hundred and nineteen patients were included. There was no relation between coffee consumption and total seizure frequency (p = 0.902). In contrast, the number of FBTCS reported over the past year was significantly associated with usual coffee consumption (p = 0.029). Specifically, number of FBCTS in patients who reported moderate coffee consumption was lower than in others. In comparison with patients with moderate coffee consumption, the odds ratio (95%CI) for reporting at least 1 FBTCS per year was 1.6 (1.03-2.49) in patients who never take coffee, 1.62 (1.02-2.57) in those with rare consumption and 2.05 (1.24-3.4) in those with high consumption. Multiple ordinal logistic regression showed a trend toward an association between coffee consumption and number of FBTCS (p = 0.08)., Conclusions and Relevance: Our data suggest that effect of coffee consumption on seizures might depend on dose with potential benefits on FBTCS frequency at moderate doses. These results will have to be confirmed by prospective studies., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2022
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46. CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients.
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Le Roux M, Barth M, Gueden S, Desbordes de Cepoy P, Aeby A, Vilain C, Hirsch E, de Saint Martin A, Portes VD, Lesca G, Riquet A, Chaton L, Villeneuve N, Villard L, Cances C, Valton L, Renaldo F, Vermersch AI, Altuzarra C, Nguyen-Morel MA, Van Gils J, Angelini C, Biraben A, Arnaud L, Riant F, and Van Bogaert P
- Subjects
- Ataxia, Child, Preschool, Female, Humans, Male, Spinocerebellar Ataxias, Calcium Channels genetics, Epilepsy drug therapy, Epilepsy genetics, Seizures etiology, Seizures genetics
- Abstract
CACNA1A pathogenic mutations are involved in various neurological phenotypes including episodic ataxia (EA2), spinocerebellar ataxia (SCA6), and familial hemiplegic migraine (FHM1). Epilepsy is poorly documented. We studied 18 patients (10 males) carrying de novo or inherited CACNA1A mutations, with median age of 2,5 years at epilepsy onset. Eight mutations were novel. Two variants known leading to gain of function (GOF) were found in 5 patients. Five other patients had non-sense variants leading to loss of function (LOF). Seizures were most often revealed by either status epilepticus (SE) (n = 8), eventually triggered by fever (n = 5), or absences/behavioural arrests (n = 7). Non-epileptic paroxysmal events were frequent and consisted in recurrent hemiplegic accesses (n = 9), jitteriness in the neonatal period (n = 6), and ocular paroxysmal events (n = 9). Most of the patients had early permanent cerebellar dysfunction (n = 16) and early moderate to severe global developmental delay (GDD)/intellectual deficiency (ID) (n = 17). MRI was often abnormal, with cerebellar (n = 8) and/or cerebral (n = 6) atrophy. Stroke-like occurred in 2 cases. Some antiepileptic drugs including topiramate, levetiracetam, lamotrigine and valproate were effective on seizures. Acetazolamide and calcium channel blockers were often effective when used. More than half of the patients had refractory epilepsy. CACNA1A mutation should be evoked in front of 2 main electro-clinical phenotypes that are associated with permanent cerebellar dysfunction and moderate to severe GDD/ID. The first one, found in all 5 patients with GOF variants, is characterized by intractable seizures, early and recurrent SE and hemiplegic accesses. The second, less severe, found in 5 patients with LOF variants, is characterized by refractory early onset absence seizures., Competing Interests: Declaration of competing interest None of the authors has any conflict of interest to disclose., (Copyright © 2021 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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47. Stereoelectroencephalography (SEEG) and epilepsy surgery in posttraumatic epilepsy: A multicenter retrospective study.
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Fierain A, McGonigal A, Lagarde S, Catenoix H, Valton L, Rheims S, Nica A, Trebuchon A, Carron R, and Bartolomei F
- Subjects
- Electroencephalography, Humans, Magnetic Resonance Imaging, Retrospective Studies, Stereotaxic Techniques, Young Adult, Epilepsy surgery, Hemispherectomy
- Abstract
Purpose: Posttraumatic epilepsy (PTE) is a common cause of drug-resistant epilepsy, especially in young adults. Nevertheless, such patients are not common candidates for intracranial presurgical evaluation. We investigated the role of stereoelectroencephalography (SEEG) in defining epileptogenicity and surgical strategy in patients with PTE., Methods: We analyzed ictal SEEG recordings from 18 patients. We determined the seizure onset zone (SOZ) by quantifying the epileptogenicity of the sampled structures, using the "epileptogenicity index" (EI). We also identified seizure onset patterns (SOPs) through visual and frequency analysis. Postsurgical outcome was assessed by Engel's classification., Results: The SOZ in PTE was most often located in temporal lobes, followed by frontal lobes. The SOZ was network-organized in the majority of the cases. Half of the SOP did not contain fast discharges. Half of the recordings showed SOZ that were less extensive than the posttraumatic lesions seen on brain magnetic resonance imaging (MRI). All but one operated patient benefited from tailored cortectomy. Only 3 patients were contraindicated for surgical resection due to bilateral epileptogenicity. The overall surgical outcome was good in majority of patients (67% Engel I)., Conclusion: Despite the potential risk of bilateral or multifocal epilepsy, patients with PTE may benefit from presurgical assessment in well-selected cases. In this context, SEEG allows guidance of tailored resections adapted to the SOZ., Competing Interests: Declaration of competing interest The authors have no conflict of interest to declare., (Copyright © 2020. Published by Elsevier Inc.)
- Published
- 2020
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48. Awake Craniotomy and Memory Induction Through Electrical Stimulation: Why Are Penfield's Findings Not Replicated in the Modern Era?
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Curot J, Roux FE, Sol JC, Valton L, Pariente J, and Barbeau EJ
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- Humans, Brain physiology, Craniotomy methods, Electric Stimulation, Memory physiology, Wakefulness
- Abstract
From the 1930s through the early 1960s, Wilder Penfield12 collected a large number of memories induced by electrical brain stimulation (EBS) during awake craniotomy. As a result, he was a major contributor to several neuroscientific and neuropsychological concepts of long-term memory. His 1963 paper, which recorded all the cases of memories he induced in his operating room, remains a substantial point of reference in neuroscience in 2019, although some of his interpretations are now debatable. However, it is highly surprising that, since Penfield's12 reports, there has been no other surgical publication on memories induced during awake surgery. In this review, we explore this phenomenon and analyze some of the reasons that might explain it. We hypothesize that the main reasons for lack of subsequent reports are related to changes in operative procedures (ie, use of anesthetics, time constraints, and insufficient debriefings) and changes in EBS parameters, rather than to the sites that are stimulated, the pathology treated, or the tasks used. If reminiscences are still induced, they should be reported in detail to add valuable contributions to the understanding of long-term memory networks, especially memories that are difficult to reproduce in the laboratory, such as autobiographical memories., (Copyright © 2020 by the Congress of Neurological Surgeons.)
- Published
- 2020
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49. Recording local field potential and neuronal activity with tetrodes in epileptic patients.
- Author
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Despouy E, Curot J, Reddy L, Nowak LG, Deudon M, Sol JC, Lotterie JA, Denuelle M, Maziz A, Bergaud C, Thorpe SJ, Valton L, and Barbeau EJ
- Subjects
- Action Potentials, Electrodes, Electrodes, Implanted, Humans, Seizures, Epilepsy, Neurons
- Abstract
Background: Recordings with tetrodes have proven to be more effective in isolating single neuron spiking activity than with single microwires. However, tetrodes have never been used in humans. We report on the characteristics, safety, compatibility with clinical intracranial recordings in epileptic patients, and performance, of a new type of hybrid electrode equipped with tetrodes., New Method: 240 standard clinical macroelectrodes and 102 hybrid electrodes were implanted in 28 patients. Hybrids (diameter 800 μm) are made of 6 or 9 macro-contacts and 2 or 3 tetrodes (diameter 70-80 μm)., Results: No clinical complication or adverse event was associated with the hybrids. Impedance and noise of recordings were stable over time. The design enabled multiscale spatial analyses that revealed physiopathological events which were sometimes specific to one tetrode, but could not be recorded on the macro-contacts. After spike sorting, the single-unit yield was similar to other hybrid electrodes and was sometimes as high as >10 neurons per tetrode., Comparison With Existing Method(s): This new hybrid electrode has a smaller diameter than other available hybrid electrodes. It provides novel spatial information due to the configuration of the tetrodes. The single-unit yield appears promising., Conclusions: This new hybrid electrode is safe, easy to use, and works satisfactorily for conducting multi-scale seizure and physiological analyses., Competing Interests: Declaration of Competing Interest ED is funded through a CIFRE industrial research agreement (no. 2015/1135) signed between DIXI Medical and the Centre de Recherche Cerveau et Cognition (CerCo). The remaining authors have no conflicts of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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50. A Fast Visual Recognition Memory System in Humans Identified Using Intracerebral ERP.
- Author
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Despouy E, Curot J, Deudon M, Gardy L, Denuelle M, Sol JC, Lotterie JA, Valton L, and Barbeau EJ
- Subjects
- Adult, Drug Resistant Epilepsy diagnosis, Drug Resistant Epilepsy physiopathology, Drug Resistant Epilepsy psychology, Female, Humans, Male, Middle Aged, Photic Stimulation methods, Time Factors, Young Adult, Brain physiology, Electrocorticography methods, Evoked Potentials, Visual physiology, Memory physiology, Recognition, Psychology physiology, Visual Perception physiology
- Abstract
One key item of information retrieved when surveying our visual world is whether or not objects are familiar. However, there is no consensus on the respective roles of medial temporal lobe structures, particularly the perirhinal cortex (PRC) and hippocampus. We considered whether the PRC could support a fast recognition memory system independently from the hippocampus. We recorded the intracerebral electroencephalograph activity of epileptic patients while they were performing a fast visual recognition memory task, constraining them to use their quickest strategy. We performed event-related potential (ERP) and classification analyses. The PRC was, by far, the earliest region involved in recognition memory. This activity occurred before the first behavioral responses and was found to be related to reaction times, unlike the hippocampus. Single-trial analyses showed that decoding power was equivalent in the PRC and hippocampus but occurred much earlier in the PRC. A critical finding was that recognition memory-related activity occurred in different frontal and parietal regions, including the supplementary motor area, before the hippocampus. These results, based on ERP analyses, suggest that the human brain is equipped with a fast recognition memory system, which may bypass the hippocampus and in which the PRC plays a critical role., (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2020
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