Author: "Valsecchi. MG" - Searchworks@Jio Institute Digital Library Search Results

578 results on '"Valsecchi. MG"'

1. Basket trials in very rare diseases: are they feasible?

Author: Risca, G, Zheng, H, Valsecchi, M, Galimberti, S, Valsecchi, MG, Galimberti, S., Risca, G, Zheng, H, Valsecchi, M, Galimberti, S, Valsecchi, MG, and Galimberti, S.
Abstract: Background In recent years, innovative designs have been proposed in the context of personalized medicine to study the effect of single/multiple drugs on multiple/single sub-populations simultaneously. Specifically, basket trials are used to study a single targeted therapy in multiple diseases or disease types sharing common genetic characteristics. This approach is very useful in rare diseases, where basket trials allow for a more efficient analysis due to borrowing of information across sub-trials. Explicitly, the treatment effect in each sub-trial may provide information on the treatment effect in other sub-trials. Our aim is to assess the feasibility and robustness of a basket design in the setting of very rare diseases, an even more challenging situation. Methods The clinical setting of interest involves a few trials, each one using the same therapy on very small numbers of patients with different diseases. We evaluated the standard Bayesian approaches on a binary and a continuous endpoint. To achieve concurrent borrowing of information, several methods for a binary outcome have been considered: i) the standard Bayesian hierarchical model (1), ii) the exchangeability nonexchangeability model by Neuenschwander (2) and iii) its recent improvement given by Daniells (3). The case of a continuous endpoint, which might be very informative when the innovative treatment is highly effective, has been addressed with the strategy proposed by Ouma (4). Our simulation study considered various scenarios characterised by the treatment effects of about five sub-trials, each involving a maximum of 15 subjects. Results The results of the simulation study suggest that basket trials are feasible even in the context of very rare diseases, especially when the effect size is large and consistent across sub-trials. Conclusions Operating characteristics of the different approaches showed promising results. This encourages our further work to investigate leveraging external information
Published: 2024

2. BIVARIATE COPULA MODELS IN THE PRESENCE OF COMPLEX PATTERNS FOR THE SURROGATE ENDPOINT FOR A SURVIVAL TRUE ENDPOINT

Author: Capitoli, G, Rotolo, F, Risca, G, Galimberti, S, Valsecchi, M, Valsecchi, MG, Capitoli, G, Rotolo, F, Risca, G, Galimberti, S, Valsecchi, M, and Valsecchi, MG
Abstract: Introduction The selection of the primary "endpoint" is a very important step in the design of clinical trials. Typically, a clinical trial aims to assess the treatment's effect on this endpoint. It often appears, however, that the most sensitive and relevant clinical endpoint, which will be called the "true" endpoint, might be difficult to assess, and to overcome this problem, a seemingly attractive solution is to replace the true endpoint with another one, which is measured earlier, more conveniently or more frequently. Such a "replacement" endpoint is termed a "surrogate" endpoint and aims to evaluate the effect of a specific treatment for a specific disease. Once a candidate surrogate is identified according to specific properties, several formal methods are available for validating the surrogate endpoint, depending on the number of trials performed. The first formal statistical approach dates back to 1989, when Prentice proposed a definition of a surrogate endpoint and four criteria to validate it. The most important criterion among these is "The Prentice's Criterion", which implies that the surrogate captures the full effect of treatment upon the true endpoint. A meta-analytic approach to validating a surrogate endpoint was recently proposed for a multi-trial context [1-3]. It consists in estimating associations at two different levels: the association between the surrogate and the clinical endpoint, called the "individual-level association", and the association between the effect of treatment on the surrogate and on the clinical endpoint, called "trial-level association". A good surrogate has biological/clinical plausibility and is shown, statistically, to have strong individual-level and trial-level associations with the true endpoint. In hematological malignancies, Minimal Residual Disease (MRD) −which measures residual leukemic cell concentration in the blood or the bone marrow− is a promising early endpoint. However, despite the strong rationale, the MRD
Published: 2024

3. The Role for Tocilizumab in COVID-19 Patients: Reflections on Monza Cohort Data

Author: Capici S, Sala L, Galimberti S, Valsecchi MG, Squillace N, Gustinetti G, Cazzaniga ME, and Bonfanti P
Subjects: sars-cov-2, covid-19, pneumonia, tocilizumab, Infectious and parasitic diseases, RC109-216
Abstract: Serena Capici,1,* Luca Sala,1,* Stefania Galimberti,2 Maria Grazia Valsecchi,2 Nicola Squillace,3 Giulia Gustinetti,3 Marina Elena Cazzaniga,1,4 Paolo Bonfanti3,4 1Phase 1 Research Unit, ASST Monza, Monza, Italy; 2Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy; 3Infectious Disease Unit, ASST Monza, Monza, Italy; 4School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy*These authors contributed equally to this workCorrespondence: Marina Elena CazzanigaPhase 1 Research Unit, ASST Monza, Monza, ItalyTel +390392339037Email marina.cazzaniga@asst-monza.itAbstract: The severe acute respiratory syndrome coronavirus 2 pandemic has dominated the global health scenario from the beginning of 2020 and still represents a major health emergency. Cytokine inhibitors as tocilizumab have been used to treat COVID-19 severe pneumonia with conflicting results. We performed a retrospective study whose results can contribute to the general overview regarding the role of these agents in severe COVID-19 pneumonia, suggesting an interesting, even not statistically significant evidence of the effectiveness of tocilizumab treatment in this disease and sow a seed of reflection about their use in future waves of pandemic. We compared two cohorts of patients treated with local standard of care and with tocilizumab in the experimental one. With a median follow-up of 92 days, deaths were 6 and 16 in the tocilizumab and the standard of care group, respectively. With a longer follow-up than previous studies, a trend in difference with regards to mortality of the groups was observed.Keywords: Sars-Cov-2, COVID-19, pneumonia, tocilizumab
Published: 2021

4. Early Onset Delirium During Hospitalization Increases In-Hospital and Postdischarge Mortality in COVID-19 Patients: A Multicenter Prospective Study

Author: Trevisan, C, Grande, G, Rebora, P, Zucchelli, A, Valsecchi, M, Focà, E, Ecarnot, F, Marengoni, A, Bellelli, G, Valsecchi, MG, Trevisan, C, Grande, G, Rebora, P, Zucchelli, A, Valsecchi, M, Focà, E, Ecarnot, F, Marengoni, A, Bellelli, G, and Valsecchi, MG
Abstract: Objective: Delirium is a common feature in COVID-19 patients. Although its association with in-hospital mortality has previously been reported, data concerning postdischarge mortality and delirium subtypes are scarce. We evaluated the association between delirium and its subtypes and both in-hospital and postdischarge mortality. Methods: This multicenter longitudinal clinical-based study was conducted in Monza and Brescia, Italy. The study population included 1,324 patients (median age: 68 years) with COVID-19 admitted to 4 acute clinical wards in northern Italy during the first pandemic waves (February 2020 to January 2021). Delirium within 48 hours of hospital admission was assessed through validated scores and/or clinically according to DSM-5 criteria. The association of delirium—and its subtypes—with in-hospital and postdischarge mortality (over a median observation period of 257 [interquartile range: 189–410] days) was evaluated through Cox proportional hazards models. Results: The 223 patients (16.8%) presenting delirium had around 2-fold increased in-hospital (hazard ratio [HR] = 1.94; 95% CI, 1.38–2.73) and postdischarge (HR = 2.01; 95% CI, 1.48–2.73) mortality than those without delirium. All delirium subtypes were associated with greater risk of death compared to the absence of delirium, but hypoactive delirium revealed the strongest associations with both in-hospital (HR=2.03; 95% CI, 1.32–3.13) and postdischarge (HR=2.22; 95% CI, 1.52–3.26) mortality. Conclusions: In patients with COVID-19, early onset delirium is associated not only with in-hospital mortality but also with shorter postdischarge survival. This suggests that delirium detection and management are crucial to improving the prognosis of COVID-19 patients.
Published: 2023

5. Validation of a skewed surrogate endpoint for a time-to-event outcome: the use of a Zaga distribution

Author: Risca, G, Capitoli, G, Rotolo, F, Galimberti, S, Valsecchi, M, Valsecchi, MG, Risca, G, Capitoli, G, Rotolo, F, Galimberti, S, Valsecchi, M, and Valsecchi, MG
Published: 2023

6. Hypersensitivity Reactions to Native E. coli L-asparaginase in Children with Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction

Author: Moricke, A, Rizzari, C, Alten, J, Attarbaschi, A, Beier, R, Biondi, A, Burkhardt, B, Bodmer, N, Boos, J, Cario, G, Conter, V, Flotho, C, Kulozik, A, Lanvers-Kaminsky, C, Mann, G, Niggli, F, Silvestri, D, Von Stackelberg, A, Stanulla, M, Valsecchi, M, Schrappe, M, Zimmermann, M, Moricke A., Rizzari C., Alten J., Attarbaschi A., Beier R., Biondi A., Burkhardt B., Bodmer N., Boos J., Cario G., Conter V., Flotho C., Kulozik A., Lanvers-Kaminsky C., Mann G., Niggli F., Silvestri D., Von Stackelberg A., Stanulla M., Valsecchi MG., Schrappe M., Zimmermann M., Moricke, A, Rizzari, C, Alten, J, Attarbaschi, A, Beier, R, Biondi, A, Burkhardt, B, Bodmer, N, Boos, J, Cario, G, Conter, V, Flotho, C, Kulozik, A, Lanvers-Kaminsky, C, Mann, G, Niggli, F, Silvestri, D, Von Stackelberg, A, Stanulla, M, Valsecchi, M, Schrappe, M, Zimmermann, M, Moricke A., Rizzari C., Alten J., Attarbaschi A., Beier R., Biondi A., Burkhardt B., Bodmer N., Boos J., Cario G., Conter V., Flotho C., Kulozik A., Lanvers-Kaminsky C., Mann G., Niggli F., Silvestri D., Von Stackelberg A., Stanulla M., Valsecchi MG., Schrappe M., and Zimmermann M.
Published: 2023

7. Hypersensitivity Reactions to Native E. coli L-asparaginase in Children with Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction

Author: Moricke A., Rizzari C., Alten J., Attarbaschi A., Beier R., Biondi A., Burkhardt B., Bodmer N., Boos J., Cario G., Conter V., Flotho C., Kulozik A., Lanvers-Kaminsky C., Mann G., Niggli F., Silvestri D., Von Stackelberg A., Stanulla M., Valsecchi MG., Schrappe M., Zimmermann M., Moricke, A, Rizzari, C, Alten, J, Attarbaschi, A, Beier, R, Biondi, A, Burkhardt, B, Bodmer, N, Boos, J, Cario, G, Conter, V, Flotho, C, Kulozik, A, Lanvers-Kaminsky, C, Mann, G, Niggli, F, Silvestri, D, Von Stackelberg, A, Stanulla, M, Valsecchi, M, Schrappe, M, and Zimmermann, M
Subjects: acute lymphoblastic leukemia, immunotherapy, MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, chemotherapy, childhood
Published: 2023

8. Serum anti-Müllerian hormone as a marker of ovarian reserve after cancer treatment and/or hematopoietic stem cell transplantation in childhood: proposal for a systematic approach to gonadal assessment

Author: Molinari S, Parissone F, Evasi V, P De Lorenzo, Valsecchi MG, Cesaro S, Fraschini D, Sangalli R, Cacace G, Biondi A, Balduzzi A, and Cattoni A
Subjects: General Economics, Econometrics and Finance
Published: 2022
Full Text: View/download PDF

9. The effect of frailty on in-hospital and medium-term mortality of patients with COronaVIrus Disease-19: the FRACOVID study

Author: Rebora, P, Focà, E, Salvatori, A, Zucchelli, A, Ceravolo, I, Ornago, A, Finazzi, A, Arsuffi, S, Bonfanti, P, Citerio, G, Mazzola, P, Ecarnot, F, Valsecchi, M, Marengoni, A, Bellelli, G, Ornago, AM, Valsecchi, MG, marengoni, A, Rebora, P, Focà, E, Salvatori, A, Zucchelli, A, Ceravolo, I, Ornago, A, Finazzi, A, Arsuffi, S, Bonfanti, P, Citerio, G, Mazzola, P, Ecarnot, F, Valsecchi, M, Marengoni, A, Bellelli, G, Ornago, AM, Valsecchi, MG, and marengoni, A
Abstract: BacKGrOUnd: Older people hospitalized for cOvid-19 are at highest risk of death. Frailty assessment can detect heterogeneity in risk among people of the same chronological age. We investigated the association between frailty and in-hospital and medium-term mortality in middle-aged and older adults with COVID-19 during the first two pandemic waves. meTHOdS: This study is an observational multicenter study. We recorded sociodemographic factors (age, sex), smoking status, date of symp-tom onset, biological data, need for supplemental oxygen, comorbidities, cognitive and functional status, in-hospital mortality. We calculated a Frailty Index (FI) as the ratio between deficits presented and total deficits considered for each patient (theoretical range 0-1). We also assessed the clinical Frailty Scale (cFS). mortality at follow-up was ascertained from a regional registry. reSULTS: in total, 1344 patients were included; median age 68 years (Q1-Q3, 56-79); 857 (64%) were men. median cFS score was 3 (Q1-Q3 2-5) and was lower in younger vs. older patients. median Fi was 0.06 (Q1-Q3 0.03-0.09) and increased with increasing age. Overall, 244 (18%) patients died in-hospital and 288 (22%) over a median follow-up of 253 days. FI and CFS were significantly associated with risk of death. In two different models using the same covariates, each increment of 0.1 in Fi increased the overall hazard of death by 35% (Hr=1.35, 95%ci 1.23-1.48), similar to the hazard for each increment of cFS (Hr=1.37, 95%ci 1.25-1.50). cOncLUSiOnS: Frailty, assessed with the Fi or cFS, predicts in-hospital and medium-term mortality and may help estimate vulnerability in middle-aged and older cOvid-19 patients.
Published: 2022

10. The association between low skeletal muscle mass and delirium: results from the nationwide multi-centre Italian Delirium Day 2017

Author: Zucchelli, A, Manzoni, F, Morandi, A, Di Santo, S, Rossi, E, Valsecchi, Mg, Inzitari, M, Cherubini, A, Bo, M, Mossello, E, Marengoni, A, Bellelli, G, Tarasconi, A, Sella, M, Auriemma, S, Paternò, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Margola, A, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Giani, A, Famularo, S, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Monacelli, F, Candiani, T, Ballestrero, A, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, De, F, Pietrogrande, L, De, B, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Bianchetti, A, Crucitti, A, Di Francesco, V, Fontana, G, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cannistrà, U, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambara, V, Saitta, A, Corica, F, Braga, M, Ettorre, E, Camellini, C, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuari, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Di, M, Degl'Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, D'Imporzano, E, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samy Salama Fahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Pezzoni, D, Gentile, S, Platto, C, D'Ambrosio, V, Faraci, B, Brambilla, C, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Confente, S, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, C Boffelli S, Corsini, Filippi, A, Delpin, K, Bertoletti, E, Vannucci, M, Tesi, F, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Riva, E, Dell'Acqua, D, Cottino, M, Vezzadini, G, Avanzi, S, Orini, S, Sgrilli, F, Mello, A, Lombardi, L, Muti, E, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Riccò, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, A Millul A, Barelli, De, G, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cat, C, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Scapigliati, A, Cortegiani, A, Vitale, F, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccalà, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D., Zucchelli, A, Manzoni, F, Morandi, A, Di Santo, S, Rossi, E, Valsecchi, M, Inzitari, M, Cherubini, A, Bo, M, Mossello, E, Marengoni, A, Bellelli, G, Citerio, G, Zucchelli, Alberto, Valsecchi, M G, and A Tarasconi, M Sella, S Auriemma, G Paternò, G Faggian, C Lucarelli, N De Grazia, C Alberto, A Margola, L Porcella, I Nardiello, E Chimenti, M Zeni, A Giani, S Famularo, E Romairone, C Minaglia, C Ceccotti, G Guerra, G Mantovani, F Monacelli, C Minaglia, T Candiani, A Ballestrero, C Minaglia, F Santolini, C Minaglia, M Rosso, V Bono, S Sibilla, P Dal Santo, M Ceci, P Barone, T Schirinzi, A Formenti, G Nastasi, G Isaia, D Gonella, A Battuello, S Casson, D Calvani, F Boni, A Ciaccio, R Rosa, G Sanna, S Manfredini, L Cortese, M Rizzo, R Prestano, A Greco, M Lauriola, G Gelosa, V Piras, M Arena, D Cosenza, A Bellomo, M LaMontagna, L Gabbani, L Lambertucci, S Perego, G Parati, G Basile, V Gallina, G Pilone, C Giudice, F De, L Pietrogrande, B De, M Mosca, I Corazzin, P Rossi, V Nunziata, F D'Amico, A Grippa, S Giardini, R Barucci, A Cossu, L Fiorin, M Arena, M Distefano, M Lunardelli, M Brunori, I Ruffini, E Abraham, A Varutti, E Fabbro, A Catalano, G Martino, D Leotta, A Marchet, G Dell'Aquila, A Scrimieri, M Davoli, M Casella, A Cartei, G Polidori, G Basile, D Brischetto, S Motta, R Saponara, P Perrone, G Russo, D Del, C Car, T Pirina, S Franzoni, A Cotroneo, F Ghiggia, G Volpi, C Menichetti, M Bo, A Panico, P Calogero, G Corvalli, M Mauri, E Lupia, R Manfredini, F Fabbian, A March, M Pedrotti, M Veronesi, E Strocchi, A Bianchetti, A Crucitti, V Di Francesco, G Fontana, L Bonanni, F Barbone, C Serrati, G Ballardini, M Simoncelli, G Ceschia, C Scarpa, R Brugiolo, S Fusco, T Ciarambino, C Biagini, E Tonon, M Porta, D Venuti, M DelSette, M Poeta, G Barbagallo, G Trovato, A Delitala, P Arosio, F Reggiani, G Zuliani, B Ortolani, E Mussio, A Girardi, A Coin, G Ruotolo, A Castagna, M Masina, R Cimino, A Pinciaroli, G Tripodi, U Cannistrà, F Cassadonte, M Vatrano, F Cassandonte, L Scaglione, P Fogliacco, C Muzzuilini, F Romano, A Padovani, L Rozzini, A Cagnin, F Fragiacomo, G Desideri, E Liberatore, A Bruni, G Orsitto, M Franco, L Bonfrate, M Bonetto, N Pizio, G Magnani, G Cecchetti, A Longo, V Bubba, L Marinan, M Cotelli, M Turla, M Brunori, M Sessa, L Abruzzi, G Castoldi, D LoVetere, C Musacchio, M Novello, A Cavarape, A Bini, A Leonardi, F Seneci, W Grimaldi, F Fimognari, V Bambara, A Saitta, F Corica, M Braga, E Ettorre, C Camellini, A Marengoni, A Bruni, A Crescenzo, G Noro, R Turco, M Ponzetto, L Giuseppe, B Mazzei, G Maiuri, D Costaggiu, R Damato, E Fabbro, G Patrizia, L Santuari, M Gallucci, C Minaglia, M Paragona, P Bini, D Modica, C Abati, M Clerici, I Barbera, F NigroImperiale, A Manni, C Votino, C Castiglioni, M Di, M Degl'Innocenti, G Moscatelli, S Guerini, C Casini, D Dini, S DeNotariis, F Bonometti, C Paolillo, A Riccardi, A Tiozzo, A SamySalamaFahmy, A Riccardi, C Paolillo, M DiBari, S Vanni, A Scarpa, D Zara, P Ranieri, P Calogero, G Corvalli, D Pezzoni, S Gentile, A Morandi, C Platto, V D'Ambrosio, B Faraci, C Ivaldi, P Milia, F DeSalvo, C Solaro, M Strazzacappa, M Bo, A Panico, M Cazzadori, S Confente, M Bonetto, G Magnani, G Cecchetti, V Guerini, B Bernardini, C Corsini, S Boffelli, A Filippi, K Delpin, E Bertoletti, M Vannucci, F Tesi, P Crippa, A Malighetti, C Caltagirone, S DiSant, D Bettini, F Maltese, M Formilan, G Abruzzese, C Minaglia, D Cosimo, M Azzini, M Cazzadori, M Colombo, G Procino, S Fascendini, F Barocco, P Del, F D'Amico, A Grippa, A Mazzone, E Riva, D Dell'Acqua, M Cottino, G Vezzadini, S Avanzi, S Orini, F Sgrilli, A Mello, L Lombardi, E Muti, B Dijk, S Fenu, C Pes, P Gareri, A Castagna, M Passamonte, F De, R Rigo, L Locusta, L Caser, G Rosso, S Cesarini, R Cozzi, C Santini, P Carbone, I Cazzaniga, R Lovati, A Cantoni, P Ranzani, D Barra, G Pompilio, S Dimori, S Cernesi, C Riccò, F Piazzolla, E Capittini, C Rota, F Gottardi, L Merla, A Barelli, A Millul, G De, G Morrone, M Bigolari, C Minaglia, M Macchi, F Zambon, F D'Amico, F D'Amico, C Pizzorni, G DiCasaleto, G Menculini, M Marcacci, G Catanese, D Sprini, T DiCasalet, M Bocci, S Borga, P Caironi, C Cat, E Cingolani, L Avalli, G Greco, G Citerio, L Gandini, G Cornara, R Lerda, L Brazzi, F Simeone, M Caciorgna, D Alampi, S Francesconi, E Beck, B Antonini, K Vettoretto, M Meggiolaro, E Garofalo, A Bruni, S Notaro, R Varutti, F Bassi, G Mistraletti, A Marino, R Rona, E Rondelli, I Riva, A Scapigliati, A Cortegiani, F Vitale, L Pistidda, R D'Andrea, L Querci, P Gnesin, M Todeschini, M Lugano, G Castelli, M Ortolani, A Cotoia, S Maggiore, L DiTizio, R Graziani, I Testa, E Ferretti, C Castioni, F Lombardi, R Caserta, M Pasqua, S Simoncini, F Baccarini, M Rispoli, F Grossi, L Cancelliere, M Carnelli, F Puccini, G Biancofiore, A Siniscalchi, C Laici, E Mossello, M Torrini, G Pasetti, S Palmese, R Oggioni, V Mangani, S Pini, M Martelli, E Rigo, F Zuccalà, A Cherri, R Spina, I Calamai, N Petrucci, A Caicedo, F Ferri, P Gritti, N Brienza, R Fonnesu, M Dessena, G Fullin, D Saggioro
Subjects: Male, Aging, medicine.medical_specialty, Sarcopenia, medicine.medical_treatment, Socio-culturale, Older person, Logistic regression, Delirium, Older persons, Sarcopenia, Internal medicine, mental disorders, Delirium, Older persons, medicine, Dementia, Humans, LS4_4, Muscle, Skeletal, Pathological, Aged, Rehabilitation, business.industry, Area under the curve, Settore MED/23 - Chirurgia Cardiaca, Skeletal, medicine.disease, Skeletal muscle mass, Cross-Sectional Studies, Italy, Muscle, Female, Geriatrics and Gerontology, medicine.symptom, business
Abstract: Introduction Delirium and sarcopenia are common, although underdiagnosed, geriatric syndromes. Several pathological mechanisms can link delirium and low skeletal muscle mass, but few studies have investigated their association. We aimed to investigate (1) the association between delirium and low skeletal muscle mass and (2) the possible role of calf circumference mass in finding cases with delirium. Methods The analyses were conducted employing the cross-sectional “Delirium Day” initiative, on patient 65 years and older admitted to acute hospital medical wards, emergency departments, rehabilitation wards, nursing homes and hospices in Italy in 2017. Delirium was diagnosed as a 4 + score at the 4-AT scale. Low skeletal muscle mass was operationally defined as calf circumference ≤ 34 cm in males and ≤ 33 cm in females. Logistic regression models were used to investigate the association between low skeletal muscle mass and delirium. The discriminative ability of calf circumference was evaluated using non-parametric ROC analyses. Results A sample of 1675 patients was analyzed. In total, 73.6% of participants had low skeletal muscle mass and 24.1% exhibited delirium. Low skeletal muscle mass and delirium showed an independent association (OR: 1.50; 95% CI 1.09–2.08). In the subsample of patients without a diagnosis of dementia, the inclusion of calf circumference in a model based on age and sex significantly improved its discriminative accuracy [area under the curve (AUC) 0.69 vs 0.57, p Discussion and conclusion Low muscle mass is independently associated with delirium. In patients without a previous diagnosis of dementia, calf circumference may help to better identify those who develop delirium.
Published: 2022

11. Delirium and Clusters of Older Patients Affected by Multimorbidity in Acute Hospitals

Author: Monacelli, F, Signori, A, Marengoni, A, Di Santo, S, Rossi, E, Valsecchi, Mg, Morandi, A, Bellelli, G, Tarasconi, A, Sella, M, Auriemma, S, Paternò, G, Faggian, G, Lucarelli, C, De Grazia, N, Alberto, C, Porcella, L, Nardiello, I, Chimenti, E, Zeni, M, Giani, A, Famularo, S, Romairone, E, Minaglia, C, Ceccotti, C, Guerra, G, Mantovani, G, Candiani, T, Ballestrero, A, Santolini, F, Rosso, M, Bono, V, Sibilla, S, Dal Santo, P, Ceci, M, Barone, P, Schirinzi, T, Formenti, A, Nastasi, G, Isaia, G, Gonella, D, Battuello, A, Casson, S, Calvani, D, Boni, F, Ciaccio, A, Rosa, R, Sanna, G, Manfredini, S, Cortese, L, Rizzo, M, Prestano, R, Greco, A, Lauriola, M, Gelosa, G, Piras, V, Arena, M, Cosenza, D, Bellomo, A, Lamontagna, M, Gabbani, L, Lambertucci, L, Perego, S, Parati, G, Basile, G, Gallina, V, Pilone, G, Giudice, C, Pietrogrande, L, Mosca, M, Corazzin, I, Rossi, P, Nunziata, V, D'Amico, F, Grippa, A, Giardini, S, Barucci, R, Cossu, A, Fiorin, L, Distefano, M, Lunardelli, M, Brunori, M, Ruffini, I, Abraham, E, Varutti, A, Fabbro, E, Catalano, A, Martino, G, Leotta, D, Marchet, A, Dell'Aquila, G, Scrimieri, A, Davoli, M, Casella, M, Cartei, A, Polidori, G, Brischetto, D, Motta, S, Saponara, R, Perrone, P, Russo, G, Del, D, Car, C, Pirina, T, Franzoni, S, Cotroneo, A, Ghiggia, F, Volpi, G, Menichetti, C, Bo, M, Panico, A, Calogero, P, Corvalli, G, Mauri, M, Lupia, E, Manfredini, R, Fabbian, F, March, A, Pedrotti, M, Veronesi, M, Strocchi, E, Borghi, C, Bianchetti, A, Crucitti, A, Difrancesco, V, Fontana, G, Bonanni, L, Barbone, F, Serrati, C, Ballardini, G, Simoncelli, M, Ceschia, G, Scarpa, C, Brugiolo, R, Fusco, S, Ciarambino, T, Biagini, C, Tonon, E, Porta, M, Venuti, D, Delsette, M, Poeta, M, Barbagallo, G, Trovato, G, Delitala, A, Arosio, P, Reggiani, F, Zuliani, G, Ortolani, B, Mussio, E, Girardi, A, Coin, A, Ruotolo, G, Castagna, A, Masina, M, Cimino, R, Pinciaroli, A, Tripodi, G, Cannistrà, U, Cassadonte, F, Vatrano, M, Scaglione, L, Fogliacco, P, Muzzuilini, C, Romano, F, Padovani, A, Rozzini, L, Cagnin, A, Fragiacomo, F, Desideri, G, Liberatore, E, Bruni, A, Orsitto, G, Franco, M, Bonfrate, L, Bonetto, M, Pizio, N, Magnani, G, Cecchetti, G, Longo, A, Bubba, V, Marinan, L, Cotelli, M, Turla, M, Sessa, M, Abruzzi, L, Castoldi, G, Lovetere, D, Musacchio, C, Novello, M, Cavarape, A, Bini, A, Leonardi, A, Seneci, F, Grimaldi, W, Fimognari, F, Bambara, V, Saitta, A, Corica, F, Braga, M, Ettorre, E, Camellini, C, Annoni, G, Crescenzo, A, Noro, G, Turco, R, Ponzetto, M, Giuseppe, L, Mazzei, B, Maiuri, G, Costaggiu, D, Damato, R, Formilan, M, Patrizia, G, Santuari, L, Gallucci, M, Paragona, M, Bini, P, Modica, D, Abati, C, Clerici, M, Barbera, I, Nigroimperiale, F, Manni, A, Votino, C, Castiglioni, C, Degl'Innocenti, M, Moscatelli, G, Guerini, S, Casini, C, Dini, D, D'Imporzano, E, Denotariis, S, Bonometti, F, Paolillo, C, Riccardi, A, Tiozzo, A, Samy Salama Fahmy, A, Dibari, M, Vanni, S, Scarpa, A, Zara, D, Ranieri, P, Alessandro, M, Pezzoni, D, Platto, C, D'Ambrosio, V, Ivaldi, C, Milia, P, Desalvo, F, Solaro, C, Strazzacappa, M, Cazzadori, M, Confente, S, Grasso, M, Troisi, E, Guerini, V, Bernardini, B, Corsini, C, Boffelli, S, Filippi, A, Delpin, K, Faraci, B, Bertoletti, E, Vannucci, M, Tesi, F, Crippa, P, Malighetti, A, Caltagirone, C, Disant, S, Bettini, D, Maltese, F, Abruzzese, G, Cosimo, D, Azzini, M, Colombo, M, Procino, G, Fascendini, S, Barocco, F, Del, P, Mazzone, A, Riva, E, Dell'Acqua, D, Cottino, M, Vezzadini, G, Avanzi, S, Brambilla, C, Orini, S, Sgrilli, F, Mello, A, Lombardi, L, Muti, E, Dijk, B, Fenu, S, Pes, C, Gareri, P, Passamonte, M, Rigo, R, Locusta, L, Caser, L, Rosso, G, Cesarini, S, Cozzi, R, Santini, C, Carbone, P, Cazzaniga, I, Lovati, R, Cantoni, A, Ranzani, P, Barra, D, Pompilio, G, Dimori, S, Cernesi, S, Riccò, C, Piazzolla, F, Capittini, E, Rota, C, Gottardi, F, Merla, L, Barelli, A, Millul, A, Morrone, G, Bigolari, M, Macchi, M, Zambon, F, Pizzorni, C, Dicasaleto, G, Menculini, G, Marcacci, M, Catanese, G, Sprini, D, Dicasalet, T, Bocci, M, Borga, S, Caironi, P, Cingolani, E, Avalli, L, Greco, G, Citerio, G, Gandini, L, Cornara, G, Lerda, R, Brazzi, L, Simeone, F, Caciorgna, M, Alampi, D, Francesconi, S, Beck, E, Antonini, B, Vettoretto, K, Meggiolaro, M, Garofalo, E, Notaro, S, Varutti, R, Bassi, F, Mistraletti, G, Marino, A, Rona, R, Rondelli, E, Riva, I, Cortegiani, A, Vitale, F, Pistidda, L, D'Andrea, R, Querci, L, Gnesin, P, Todeschini, M, Lugano, M, Castelli, G, Ortolani, M, Cotoia, A, Maggiore, S, Ditizio, L, Graziani, R, Testa, I, Ferretti, E, Castioni, C, Lombardi, F, Caserta, R, Pasqua, M, Simoncini, S, Baccarini, F, Rispoli, M, Grossi, F, Cancelliere, L, Carnelli, M, Puccini, F, Biancofiore, G, Siniscalchi, A, Laici, C, Mossello, E, Torrini, M, Pasetti, G, Palmese, S, Oggioni, R, Mangani, V, Pini, S, Martelli, M, Rigo, E, Zuccalà, F, Cherri, A, Spina, R, Calamai, I, Petrucci, N, Caicedo, A, Ferri, F, Gritti, P, Brienza, N, Fonnesu, R, Dessena, M, Fullin, G, Saggioro, D., Monacelli, F, Signori, A, Marengoni, A, Di Santo, S, Rossi, E, Valsecchi, M, Morandi, A, and Bellelli, G
Subjects: medicine.medical_specialty, multimorbidity, Delirium, multimorbidity, Socio-culturale, Older patients, mental disorders, Medicine, Dementia, Multimorbidity, Humans, Medical history, LS4_4, General Nursing, Aged, Aged, 80 and over, Routine screening, business.industry, Health Policy, Delirium, General Medicine, Targeted interventions, medicine.disease, Hospitals, Cross-Sectional Studies, Charlson comorbidity index, Emergency medicine, Geriatrics and Gerontology, medicine.symptom, business
Abstract: Objectives Delirium is commonly seen in older adults with multimorbidity, during a hospitalization, resulting from the interplay between predisposing factors such as advanced age, frailty, and dementia, and a series of precipitating factors. The association between delirium and specific multimorbidity is largely unexplored so far although of potential key relevance for targeted interventions. The aim of the study was to check for a potential association of multimorbidity with delirium in a large cohort of older patients hospitalized for an acute medical or surgical condition. Design This is a cross-sectional study nested in the 2017 Delirium Day project. Setting and Participants The study includes 1829 hospitalized patients (age: 81.8, SD: 5.5). Of them, 419 (22.9%) had delirium. Methods Sociodemographic and medical history were collected. The 4AT was used to assess the presence of delirium. The Charlson Comorbidity index was used to assess multimorbidity. Results The results identified neurosensorial multimorbidity as the most prevalent, including patients with dementia, cerebrovascular diseases, and sensory impairments. In light of the highest co-occurrence of 3 neurosensorial chronic conditions, we could hypothesize that a baseline altered brain functional and neural connectivity might determine the vulnerability signature for incipient overall system disruption in presence of acute insults. Conclusions and Implications Eventually, our findings moved a step forward in supporting the key importance of routine screening for sensory impairments and cognitive status of older patients for the highest risk of in-hospital delirium. In fact, preventive interventions could be particularly relevant and effective in preventing delirium in such vulnerable populations and might help refining this early diagnosis.
Published: 2022

12. Mapping the human genetic architecture of COVID-19

Author: Niemi, MEK, Karjalainen, J, Liao, RG, Neale, BM, Daly, M, Ganna, A, Pathak, GA, Andrews, SJ, Kanai, M, Veerapen, K, Fernandez-Cadenas, I, Schulte, EC, Striano, P, Marttila, M, Minica, C, Marouli, E, Karim, MA, Wendt, FR, Savage, J, Sloofman, L, Butler-Laporte, G, Kim, H-N, Kanoni, S, Okada, Y, Byun, J, Han, Y, Uddin, MJ, Smith, GD, Willer, CJ, Buxbaum, JD, Mehtonen, J, Finucane, H, Cordioli, M, Martin, AR, Zhou, W, Pasaniuc, B, Julienne, H, Aschard, H, Shi, H, Yengo, L, Polimanti, R, Ghoussaini, M, Schwartzentruber, J, Dunham, I, Chwialkowska, K, Francescatto, M, Trankiem, A, Balaconis, MK, Davis, L, Lee, S, Priest, J, Renieri, A, Sankaran, VG, van Heel, D, Deelen, P, Richards, JB, Nakanishi, T, Biesecker, L, Kerchberger, VE, Kenneth, J, Mari, F, Bernasconi, A, Ceri, S, Canakoglu, A, Wolford, B, Faucon, A, Dutta, AK, Schurmann, C, Harry, E, Birney, E, Nguyen, H, Nasir, J, Kaunisto, M, Solomonson, M, Dueker, N, Vadgama, N, Limou, S, Rahmouni, S, Mbarek, H, Darwish, D, Uddin, MM, Albertos, R, Perez-Tur, J, Li, R, Folkersen, L, Moltke, I, Koelling, N, Teumer, A, Kousathanas, A, Utrilla, A, Verdugo, RA, Zarate, R, Medina-Gomez, C, Gomez-Cabrero, D, Carnero-Montoro, E, Cadilla, CL, Moreno-Estrada, A, Garmendia, A, Moya, L, Sedaghati-Khayat, B, Boua, PR, Fave, M-J, Francioli, L, Lemacon, A, Migeotte, I, Patel, S, Varnai, R, Szentpeteri, JL, Sipeky, C, Colombo, F, von Hohenstaufen, K, Lio, P, Vallerga, C, Wang, Q, Tanigawa, Y, Im, H, Han, C, Song, H, Lim, J, Lee, Y, Kim, S, Im, S, Atanasovska, B, Ahmad, HF, Boer, C, Jansen, P, Franke, L, Kaja, E, Pasko, D, Kennis-Szilagyi, I, Kornilov, SA, Prijatelj, V, Prokic, I, Sivanadhan, I, Perumal, S, Esmaeeli, S, Pearson, NM, Auton, A, Shelton, JF, Shastri, AJ, Filshtein-Sonmez, T, Coker, D, Symons, A, Esparza-Gordillo, J, Aslibekyan, S, O'Connell, J, Ye, C, Weldon, CH, Perera, M, O'Leary, K, Tuck, M, O'Brien, T, Meltzer, D, O'Donnell, P, Nutescu, E, Yang, G, Alarcon, C, Herrmann, S, Mazurek, S, Banagan, J, Hamidi, Z, Barbour, A, Raffat, N, Moreno, D, Friedman, P, Ferwerda, B, van de Beek, D, Brouwer, MC, Vlaar, APJ, Wiersinga, WJ, Posthuma, D, Tissink, E, Zwinderman, AHK, Uffelmann, E, van Agtmael, M, Algera, AG, van Baarle, F, Bax, D, Beudel, M, Bogaard, HJ, Bomers, M, Bonta, PI, Bos, L, Botta, M, de Brabander, J, de Bree, G, de Bruin, S, Bugiani, M, Bulle, E, Chouchane, O, Cloherty, A, Dongelmans, D, Elbers, P, Fleuren, L, Geerlings, S, Geerts, B, Geijtenbeek, T, Girbes, A, Goorhuis, B, Grobusch, MP, Hafkamp, F, Hagens, L, Hamann, J, Harris, V, Hemke, R, Hermans, SM, Heunks, L, Hollmann, M, Horn, J, Hovius, JW, de Jong, MD, Koning, R, van Mourik, N, Nellen, J, Nossent, EJ, Paulus, F, Peters, E, van der Poll, T, Preckel, B, Prins, JM, Raasveld, J, Reijnders, T, Schinkel, M, Schultz, MJ, Schuurman, A, Sigaloff, K, Smit, M, Stijnis, CS, Stilma, W, Teunissen, C, Thoral, P, Tsonas, A, van der Valk, M, Veelo, D, de Vries, H, van Vugt, M, Wouters, D, Minnaar, RP, Kromhout, A, van Uffelen, KWJ, Wolterman, RA, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Bouysran, Y, Busson, A, Peyrassol, X, Wilkin, F, Pichon, B, Smits, G, Vandernoot, I, Goffard, J-C, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Jadot, L, Azarzar, S, Dellot, P, Gofflot, S, Claassen, S, Bertrand, A, Parzibut, G, Clarinval, M, Moermans, C, Malaise, O, El Kandoussi, K, Thonon, R, Huynen, P, Mesdagh, A, Melo, S, Jacques, N, Di Valentin, E, Giroule, F, Collignon, A, Radermecker, C, Lebrun, M, Peree, H, Latour, S, Barada, O, Sanchez, J, Josse, C, Boujemla, B, Meunier, M, Mariavelle, E, Anania, S, Gazon, H, Juszczak, D, Fadeur, M, Camby, S, Meuris, C, Thys, M, Jacques, J, Henket, M, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Von Frenckell, C, Mni, M, Wery, M, Staderoli, A, Belhaj, Y, Lambermont, B, Morrison, DR, Mooser, V, Forgetta, V, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chasse, M, Kaufmann, DE, Lathrop, GM, Adra, D, Davis, LK, Cox, NJ, Below, JE, Sealock, JM, Faucon, AB, Shuey, MM, Polikowsky, HG, Petty, LE, Shaw, DM, Chen, H-H, Zhu, W, Ludwig, KU, Schroeder, J, Maj, C, Rolker, S, Noethen, MM, Fazaal, J, Keitel, V, Jensen, B-EO, Feldt, T, Kurth, I, Marx, N, Dreher, M, Pink, I, Cornberg, M, Illig, T, Lehmann, C, Schommers, P, Augustin, M, Rybniker, J, Knopp, L, Eggermann, T, Volland, S, Altmueller, J, Berger, MM, Brenner, T, Hinney, A, Witzke, O, Bals, R, Herr, C, Ludwig, N, Walter, J, Fuchsberger, C, Pattaro, C, De Grandi, A, Pramstaller, P, Emmert, D, Melotti, R, Foco, L, Mascalzoni, D, Gogele, M, Domingues, F, Hicks, A, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Goldstein, DB, Kiryluk, K, Sengupta, S, Chung, W, Reilly, MP, Khan, A, Wang, C, Povysil, G, Bhardwaj, N, Gharavi, AG, Ionita-Laza, I, Shang, N, O'Byrne, SM, Nandakumar, R, Menon, A, So, YS, Hod, E, Pendrick, D, Park, S-K, Kim, H-L, Kang, CK, Lee, H-J, Song, K-H, Yoon, KJ, Paik, N-J, Seok, W, Yoon, H, Joo, E-J, Chang, Y, Ryu, S, Park, WB, Park, JS, Park, KU, Ham, SY, Jung, J, Kim, ES, Kim, HB, Ellinghaus, D, Degenhardt, F, Caceres, M, Juzenas, S, Lenz, TL, Albillos, A, Julia, A, Heidecker, B, Garcia, F, Kurth, F, Tran, F, Hanses, F, Zoller, H, Holter, JC, Fernandez, J, Sander, LE, Rosenstiel, P, Koehler, P, de Cid, R, Asselta, R, Schreiber, S, Hehr, U, Prati, D, Baselli, G, Valenti, L, Bujanda, L, Banales, JM, Duga, S, D'Amato, M, Romero-Gomez, M, Buti, M, Invernizzi, P, Franke, A, Hov, JR, Karlsen, TH, Folseraas, T, Maya-Miles, D, Teles, A, Azuure, C, Wacker, EM, Uellendahl-Werth, F, Elabd, H, Arora, J, Lerga-Jaso, J, Wienbrandt, L, Ruehlemann, MC, Wendorff, M, Vadla, MS, Lenning, OB, Oezer, O, Myhre, R, Raychaudhuri, S, Tanck, A, Gassner, C, Hemmrich-Stanisak, G, Kaessens, J, Basso, MEF, Schulzky, M, Wittig, M, Braun, N, Wesse, T, Albrecht, W, Yi, X, Ortiz, AB, Garrido Chercoles, A, Ruiz, A, Mantovani, A, Holten, AR, Mayer, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Braun, A, Barreira, A, Lleo, A, Kildal, AB, Glueck, A, Carreras Nolla, A, Latiano, A, Dyrhol-Riise, AM, Muscatello, A, Voza, A, Rando-Segura, A, Solier, A, Karina, B, Cortes, B, Mateos, B, Nafria-Jimenez, B, Schaefer, B, Bellinghausen, C, Ferrando, C, Quereda, C, Skurk, C, Thibeault, C, Spinner, CD, Lange, C, Hu, C, Cappadona, C, Bianco, C, Sancho, C, Hoff, DAL, Galimberti, D, Jimenez, D, Pestana, D, Toapanta, D, Azzolini, E, Scarpini, E, Helbig, ET, Urrechaga, E, Paraboschi, EM, Pontali, E, Reverter, E, Navas, E, Arana, E, Garcia Sanchez, F, Ceriotti, F, Malvestiti, F, Mesonero, F, Pezzoli, G, Lamorte, G, Neb, H, My, I, Hernandez, I, de Rojas, I, Galvan-Femenia, I, Heyckendorf, J, Badia, JR, Schneider, J, Goikoetxea, J, Kraft, J, Mueller, KE, Gaede, KI, Garcia-Etxebarria, K, Tonby, K, Heggelund, L, Izquierdo-Sanchez, L, Sumoy, L, Lippert, LJ, Terranova, L, Garbarino, L, Tellez, L, Roade, L, Ostadreza, M, Intxausti, M, Kogevinas, M, Gutierrez-Stampa, MA, Vehreschild, MJGT, Marquie, M, Castoldi, M, Cecconi, M, Boada, M, Seilmaier, MJ, Mazzocco, M, Rodriguez-Gandia, M, Imaz Ayo, N, Blay, N, Martinez, N, Cornely, OA, Palmieri, O, Tentorio, P, Rodrigues, PM, Espana, PP, Hoffmann, P, Bacher, P, Suwalski, P, de Pablo, R, Nieto, R, Badalamenti, S, Ciesek, S, Bombace, S, Wilfling, S, Brunak, S, Heilmann-Heimbach, S, Ripke, S, Bahmer, T, Landmesser, U, Protzer, U, Rimoldi, V, Skogen, V, Andrade, V, Moreno, V, Poller, W, Farre, X, Wang, X, Khodamoradi, Y, Karadeniz, Z, de Salazar, A, Palom, A, Garcia-Fernandez, A-E, Blanco-Grau, A, Zanella, A, Bandera, A, Nebel, A, Biondi, A, Caba Llero-Garralda, A, Gori, A, Lind, A, Fracanzani, AL, Peschuck, A, Pesenti, A, De la Horra, C, Milani, C, Paccapelo, C, Angelini, C, Cea, C, Muniz-Diaz, E, Sandoval, E, Calderon, EJ, Solligard, E, Aziz, F, Martinelli-Boneschi, F, Peyvandi, F, Blasi, F, Medrano, FJ, Rodriguez-Frias, F, Mueller, F, Grasselli, G, Costantino, G, Cardamone, G, Foti, G, Matullo, G, Kurihara, H, Afset, JE, Damas, JK, Ampuero, J, Martin, J, Erdmann, J, Bergan, J, Goerg, S, Ferrusquia-Acosta, J, Hernandez Quero, J, Delgado, J, Guerrero, JM, Risnes, K, Bettini, LR, Moreira, L, Gustad, LT, Santoro, L, Scudeller, L, Riveiro-Barciela, M, Schaefer, M, Carrabba, M, Valsecchi, MG, Hernandez-Tejero, M, Acosta-Herrera, M, D'Angio, M, Baldini, M, Cazzaniga, M, Ciccarelli, M, Bocciolone, M, Miozzo, M, Chueca, N, Montano, N, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Castro, P, Ferrer, R, Gualtierotti, R, Gallego-Duran, R, Morilla, R, Haider, S, Marsal, S, Aneli, S, Pelusi, S, Bosari, S, Aliberti, S, Dudman, S, Zheng, T, Pumarola, T, Gonzalez Cejudo, T, Monzani, V, Friaza, V, Peter, W, Dopazo, X, May, S, Grimsrud, MM, Gudbjartsson, DF, Stefansson, K, Sulem, P, Sveinbjornsson, G, Melsted, P, Norddahl, G, Moore, KHS, Thorsteinsdottir, U, Holm, H, Alarcon-Riquelme, ME, Bernardo, D, Martinez-Bueno, M, Rojo Rello, S, Magi, R, Milani, L, Metspalu, A, Laisk, T, Lall, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Palotie, A, Rivolta, C, Bochud, P-Y, Bibert, S, Boillat, N, Nussle, SG, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Bochud, PY, Friolet, R, Vollenweider, P, Pagani, JL, Oddo, M, zu Bentrup, FM, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, RM, Lannepoudenx, Y, Portopena, L, Desgranges, F, Filippidis, P, Guery, B, Haefliger, D, Kampouri, EE, Manuel, O, Munting, A, Iou-Olivgeris, MP, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hugli, O, Meuwly, JY, Pantet, O, Bochud, M, D'Acremont, V, Younes, SE, Albrich, WC, Cerny, A, O'Mahony, L, von Mering, C, Frischknecht, M, Kleger, G-R, Filipovic, M, Kahlert, CR, Wozniak, H, Negro, TR, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, Carreras, A, Mercader, JM, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castano-Vinyals, G, Dobano, C, Gori, M, Mondelli, MU, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, MA, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, GP, Spagnesi, M, Canaccini, A, Ognibene, A, Monforte, AD, Girardis, M, Antinori, A, Francisci, D, Schiaroli, E, Scotton, PG, Panese, S, Scaggiante, R, Della Monica, M, Capasso, M, Fiorentino, G, Castori, M, Aucella, F, Di Biagio, A, Masucci, L, Valente, S, Mandala, M, Zucchi, P, Giannattasio, F, Coviello, DA, Mussini, C, Bosio, G, Tavecchia, L, Crotti, L, Rizzi, M, La Rovere, MT, Sarzi-Braga, S, Bussotti, M, Ravaglia, S, Artuso, R, Perrella, A, Romani, D, Bergomi, P, Catena, E, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Di Pietro, M, Sabrina, R, Luchi, S, Barbieri, C, Acquilini, D, Andreucci, E, Paciosi, F, Segala, FV, Tiseo, G, Falcone, M, Lista, M, Poscente, M, De Vivo, O, Petrocelli, P, Guarnaccia, A, Baroni, S, Perticaroli, V, Furini, S, Dei, S, Benetti, E, Picchiotti, N, Sanarico, M, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Bergomi, M, Zguro, K, Capitani, K, Tanfoni, M, Fallerini, C, Daga, S, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, MA, Lo Rizzo, C, Pinto, AM, Beligni, G, Tommasi, A, Di Sarno, L, Palmieri, M, Carriero, ML, Alaverdian, D, Iuso, N, Inchingolo, G, Busani, S, Bruno, R, Vecchia, M, Belli, MA, Mantovani, S, Ludovisi, S, Quiros-Roldan, E, Antoni, MD, Zanella, I, Siano, M, Emiliozzi, A, Fabbiani, M, Rossetti, B, Zanelli, G, Bergantini, L, D'Alessandro, M, Cameli, P, Bennet, D, Anedda, F, Marcantonio, S, Scolletta, S, Guerrini, S, Conticini, E, Frediani, B, Spertilli, C, Donati, A, Guidelli, L, Corridi, M, Croci, L, Piacentini, P, Desanctis, E, Cappelli, S, Verzuri, A, Anemoli, V, Pancrazi, A, Lorubbio, M, Merlini, E, Miraglia, FG, Venturelli, S, Cossarizza, A, Vergori, A, Gabrieli, A, Riva, A, Andretta, F, Gatti, F, Parisi, SG, Baratti, S, Piscopo, C, Russo, R, Andolfo, I, Iolascon, A, Carella, M, Merla, G, Squeo, GM, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Sanguinetti, M, Giorli, A, Salerni, L, Parravicini, P, Menatti, E, Trotta, T, Coiro, G, Lena, F, Martinelli, E, Mancarella, S, Gabbi, C, Maggiolo, F, Ripamonti, D, Bachetti, T, Suardi, C, Parati, G, Botta, G, Di Domenico, P, Rancan, I, Bianchi, F, Colombo, R, van Heel, DA, Hunt, KA, Trembath, RC, Huang, QQ, Martin, HC, Mason, D, Trivedi, B, Wright, J, Finer, S, Griffiths, CJ, Akhtar, S, Anwar, M, Arciero, E, Ashraf, S, Breen, G, Chung, R, Curtis, CJ, Chowdhury, M, Colligan, G, Deloukas, P, Durham, C, Griffiths, C, Hurles, M, Hussain, S, Islam, K, Lavery, C, Lee, SH, Lerner, R, MacArthur, D, MacLaughlin, B, Martin, H, Miah, S, Newman, B, Safa, N, Tahmasebi, F, Smith, AV, Boughton, AP, Li, KW, LeFaive, J, Annis, A, Jannes, CE, Krieger, JE, Pereira, AC, Velho, M, Marques, E, Lima, IR, Tada, MT, Valino, K, McCarthy, M, Rosenberger, C, Lee, JE, Chang, D, Hammer, C, Hunkapiller, J, Mahajan, A, Pendergrass, S, Sucheston-Campbell, L, Yaspan, B, Lee, HS, Shin, E, Jang, HY, Kym, S, Kim, Y-S, Jeong, H, Kwon, KT, Kim, S-W, Kim, JY, Jang, YR, Kim, HA, Lee, JY, Choe, K-W, Kang, YM, Jee, SH, Jung, KJ, Parikh, V, Ashley, E, Wheeler, M, Rivas, M, Bustamante, C, Pinksy, B, Febbo, P, Farh, K, Schroth, GP, deSouza, F, Dalton, K, Christle, J, Deboever, C, Szalma, S, Rubinacci, S, Delaneau, O, Gorzynski, J, de Jong, H, Sutton, S, Youlton, N, Joshi, R, Jimenez-Morales, D, Hughes, C, Amar, D, Ioannidis, A, Hershman, S, Kirillova, A, Seo, K, Huang, Y, Shoura, M, Hammond, N, Watson, N, Raja, A, Huang, C, Sahoo, M, Wang, H, Zhen, J, Rakitko, A, Ilinsky, V, Yermakovich, D, Popov, I, Chernitsov, A, Kovalenko, E, Krasnenko, A, Plotnikov, N, Stetsenko, I, Kim, A, Cirulli, ET, Barrett, KMS, Bolze, A, White, S, Washington, NL, Lu, JT, Riffle, S, Tanudjaja, F, III, RJM, Leonetti, N, Neveux, I, Dabe, S, Grzymski, JJ, Minano, JIE, Aguirre, LA, Lopez-Collazo, E, Pazos, MDLM, Cerrato, L, Lozano-Rodriguez, R, Avendano-Ortiz, J, Terron Arcos, V, Marina Montalban-Hernandez, K, Valentin Quiroga, J, Pascual-Iglesias, A, Maroun-Eid, C, Martin-Quiros, A, Namkoong, H, Imoto, S, Katayama, K, Fukunaga, K, Kitagawa, Y, Sato, T, Hasegawa, N, Kumanogoh, A, Kimura, A, Ai, M, Tokunaga, K, Kanai, T, Miyano, S, Ogawa, S, Edahiro, R, Sonehara, K, Shirai, Y, Ishii, M, Kabata, H, Masaki, K, Kamata, H, Ikemura, S, Chubachi, S, Okamori, S, Terai, H, Tanaka, H, Morita, A, Lee, H, Asakura, T, Sasaki, J, Morisaki, H, Uwamino, Y, Nanki, K, Mikami, Y, Tomono, K, Kato, K, Matsuda, F, Takahashi, M, Hizawa, N, Takeda, Y, Hirata, H, Shiroyama, T, Miyawaki, S, Suzuki, K, Maeda, Y, Nii, T, Noda, Y, Niitsu, T, Adachi, Y, Enomoto, T, Amiya, S, Hara, R, Takahashi, K, Anzai, T, Hasegawa, T, Ito, S, Koike, R, Endo, A, Uchimura, Y, Miyazaki, Y, Honda, T, Tateishi, T, Tohda, S, Ichimura, N, Sonobe, K, Sassa, C, Nakajima, J, Nannya, Y, Omae, Y, Harada, N, Hiki, M, Takagi, H, Nakamura, A, Tagaya, E, Kawana, M, Arimura, K, Ishiguro, T, Takayanagi, N, Isono, T, Takaku, Y, Takano, K, Anan, R, Nakajima, Y, Nakano, Y, Nishio, K, Ueda, S, Hayashi, R, Tateno, H, Hase, I, Yoshida, S, Suzuki, S, Mitamura, K, Saito, F, Ueda, T, Azuma, M, Nagasaki, T, Yasui, Y, Hasegawa, Y, Mutoh, Y, Yoshiyama, T, Shoko, T, Kojima, M, Adachi, T, Ishikawa, M, Watanabe, K, Manabe, T, Ito, F, Fukui, T, Funatsu, Y, Koh, H, Hirai, Y, Kawashima, H, Narita, A, Niwa, K, Sekikawa, Y, Yoshiya, K, Yoshihara, T, Suzuki, Y, Nakayama, S, Masuzawa, K, Nishi, K, Nishitsuji, M, Tani, M, Inoue, T, Hirano, T, Kobayashi, K, Miyazawa, N, Kimura, Y, Sado, R, Ogura, T, Kitamura, H, Murohashi, K, Nakachi, I, Baba, R, Arai, D, Fuke, S, Saito, H, Kuwahara, N, Fujiwara, A, Okada, T, Baba, T, Noda, J, Mashimo, S, Yagi, K, Shiomi, T, Hashiguchi, M, Odani, T, Mochimaru, T, Oyamada, Y, Mori, N, Izumi, N, Nagata, K, Taki, R, Murakami, K, Yamada, M, Sugiura, H, Hayashi, K, Shimizu, T, Gon, Y, Fujitani, S, Tsuchida, T, Yoshida, T, Kagaya, T, Kita, T, Sakagami, S, Kimizuka, Y, Kawana, A, Nakamura, Y, Ishikura, H, Takata, T, Kikuchi, T, Taniyama, D, Nakamura, M, Kodama, N, Kaneyama, Y, Maeda, S, Nagasaki, Y, Okamoto, M, Ishihara, S, Ito, A, Chihara, Y, Takeuchi, M, Onoi, K, Hashimoto, N, Wakahara, K, Ando, A, Masuda, M, Wakabayashi, A, Watanabe, H, Sageshima, H, Nakada, T-A, Abe, R, Shimada, T, Kawamura, K, Ichikado, K, Nishiyama, K, Yamasaki, M, Hashimoto, S, Kusaka, Y, Ohba, T, Isogai, S, Takada, M, Kanda, H, Komase, Y, Sano, F, Asano, K, Oguma, T, Harada, M, Takahashi, T, Shibusawa, T, Abe, S, Kono, Y, Togashi, Y, Izumo, T, Inomata, M, Awano, N, Ogata, T, Kanehiro, A, Ozaki, S, Fuchimoto, Y, Ogura, S, Yoshida, K, Beppu, S, Fukuyama, S, Eriguchi, Y, Yonekawa, A, Inoue, Y, Yamagata, K, Chiba, S, Narumoto, O, Nagai, H, Ooshima, N, Motegi, M, Sagara, H, Tanaka, A, Ohta, S, Shibata, Y, Tanino, Y, Sato, Y, Yamada, Y, Hashino, T, Shinoki, M, Iwagoe, H, Imamura, T, Umeda, A, Shimada, H, Endo, M, Hayashi, S, Nakano, S, Yatomi, M, Maeno, T, Ishii, T, Utsugi, M, Ono, A, Kanaoka, K, Ihara, S, Komuta, K, Boezen, M, Claringbould, A, Lopera, E, Warmerdam, R, Vonk, JM, van Blokland, I, Lanting, P, Ori, APS, Obeidat, M, Cordero, AIH, Sin, DD, Bosse, Y, Joubert, P, Hao, K, Nickle, D, Timens, W, van den Berge, M, Feng, Y-CA, Mercader, J, Weiss, ST, Karlson, EW, Smoller, JW, Murphy, SN, Meigs, JB, Woolley, AE, Green, RC, Perez, EF, Zollner, S, Wang, J, Beck, A, Sloofman, LG, Ascolillo, S, Sebra, RP, Collins, BL, Levy, T, Sealfon, SC, Jordan, DM, Thompson, RC, Gettler, K, Chaudhary, K, Belbin, GM, Preuss, M, Hoggart, C, Choi, S, Underwood, SJ, Salib, I, Britvan, B, Keller, K, Tang, L, Peruggia, M, Hiester, LL, Niblo, K, Aksentijevich, A, Labkowsky, A, Karp, A, Zlatopolsky, M, Zyndorf, M, Charney, AW, Beckmann, ND, Schadt, EE, Abul-Husn, NS, Cho, JH, Itan, Y, Kenny, EE, Loos, RJF, Nadkarni, GN, Do, R, O'Reilly, P, Huckins, LM, Ferreira, MAR, Abecasis, GR, Leader, JB, Cantor, MN, Justice, AE, Carey, DJ, Chittoor, G, Josyula, NS, Kosmicki, JA, Horowitz, JE, Baras, A, Gass, MC, Yadav, A, Mirshahi, T, Hottenga, JJ, Bartels, M, de Geus, EJC, Nivard, MG, Verma, A, Ritchie, MD, Rader, D, Li, B, Verma, SS, Lucas, A, Bradford, Y, Zara, F, Salpietro, V, Scala, M, Iacomino, M, Scudieri, P, Bocciardi, R, Minetti, C, Vari, MS, Rahier, J-F, Giorgio, E, Carli, D, Louis, E, Bulik, CM, Landen, M, Brusco, A, Ferrero, GB, Madia, F, Fundin, B, Ismail, SI, Saad, C, Al-Sarraj, Y, Badji, RM, Al-Muftah, W, Al Thani, A, Afifi, N, Klovins, J, Rovite, V, Rescenko, R, Peculis, R, Ustinova, M, Zeberg, H, Frithiof, R, Hultstrom, M, Lipcsey, M, Johnson, R, Geschwind, DH, Freimer, N, Butte, MJ, Ding, Y, Chiu, A, Chang, TS, Boutros, P, Moutsianas, L, Caulfield, MJ, Scott, RH, Walker, S, Stuckey, A, Odhams, CA, Rhodes, D, Fowler, T, Rendon, A, Chan, G, Arumugam, P, Karczewski, KJ, Wilson, DJ, Spencer, CA, Crook, DW, Wyllie, DH, O'Connell, AM, Atkinson, EG, Tsuo, K, Baya, N, Turley, P, Gupta, R, Walters, RK, Palmer, DS, Sarma, G, Cheng, N, Lu, W, Churchhouse, C, Goldstein, JI, King, D, Seed, C, Daly, MJ, Bryant, S, Satterstrom, FK, Band, G, Earle, SG, Lin, S-K, Arning, N, Armstrong, J, Rudkin, JK, Callier, S, Cusick, C, Soranzo, N, Zhao, JH, Danesh, J, Di Angelantonio, E, Butterworth, AS, Sun, YV, Huffman, JE, Cho, K, O'Donnell, CJ, Tsao, P, Gaziano, JM, Peloso, G, Ho, Y-L, Mian, M, Scaggiante, F, Chang, X, Glessner, JR, Hakonarson, H, Baillie, JK, McGuigan, PJ, Moore, LSP, Vizcaychipi, MP, Hall, K, Campbell, A, Nichol, A, Ward, G, Page, VJ, Semple, MG, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Aldera, EL, Alegria, A, Angus, B, Ashish, A, Atkinson, D, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Basude, S, Baxter, D, Beadsworth, M, Bernatoniene, J, Berridge, J, Best, N, Bothma, P, Chadwick, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Child, J, Chukkambotla, S, Clark, T, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M-T, Dark, P, Dawson, C, Dervisevic, S, Donnison, P, Douthwaite, S, Drummond, A, DuRand, I, Dushianthan, A, Dyer, T, Evans, C, Eziefula, C, Fegan, C, Finn, A, Fullerton, D, Garg, S, Garg, A, Gkrania-Klotsas, E, Godden, J, Goldsmith, A, Graham, C, Hardy, E, Hartshorn, S, Harvey, D, Havalda, P, Hawcutt, DB, Hobrok, M, Hodgson, L, Hormis, A, Jacobs, M, Jain, S, Jennings, P, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kendall, J, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Laha, S, Laird, S, Larkin, S, Leiner, T, Lillie, P, Limb, J, Linnett, V, Little, J, Lyttle, M, MacMahon, M, MacNaughton, E, Mankregod, R, Masson, H, Matovu, E, McCullough, K, McEwen, R, Meda, M, Mills, GH, Minton, J, Ward, K, Mirfenderesky, M, Mohandas, K, Mok, Q, Moon, J, Moore, E, Morgan, P, Morris, C, Mortimore, K, Moses, S, Mpenge, M, Mulla, R, Murphy, M, Nagel, M, Nagarajan, T, Nelson, M, O'Shea, MK, Otahal, I, Ostermann, M, Pais, M, Panchatsharam, S, Papakonstantinou, D, Paraiso, H, Patel, B, Pattison, N, Pepperell, J, Peters, M, Phull, M, Pintus, S, Pooni, JS, Post, F, Price, D, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Roberts, M, Roberts, D, Rose, A, Rousseau, G, Ryan, B, Saluja, T, Shah, A, Shanmuga, P, Sharma, A, Shawcross, A, Sizer, J, Shankar-Hari, M, Smith, R, Snelson, C, Spittle, N, Staines, N, Stambach, T, Stewart, R, Subudhi, P, Szakmany, T, Tatham, K, Thomas, J, Thompson, C, Thompson, R, Tridente, A, Tupper-Carey, D, Twagira, M, Ustianowski, A, Vallotton, N, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Walden, A, Welters, I, Whitehouse, T, Whittaker, P, Whittington, A, Papineni, P, Wijesinghe, M, Williams, M, Wilson, L, Cole, S, Winchester, S, Wiselka, M, Wolverson, A, Wooton, DG, Workman, A, Yates, B, Young, P, Beale, R, Bretherick, AD, Clohisey, S, Fourman, MH, Furniss, J, Gountouna, E, Grimes, G, Haley, C, Harrison, D, Hayward, C, Keating, S, Klaric, L, Klenerman, P, Law, A, Meynert, AM, Millar, J, Pairo-Castineira, E, Parkinson, N, Ponting, CP, Porteous, DJ, Rawlik, K, Richmond, A, Rowan, K, Russell, CD, Shen, X, Shih, B, Tenesa, A, Vitart, V, Wang, B, Wilson, JF, Wu, Y, Yang, J, Yang, Z, Zechner, M, Zhai, R, Zheng, C, Norman, L, Pius, R, Drake, TM, Fairfield, CJ, Knight, SR, Mclean, KA, Murphy, D, Shaw, CA, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Leeming, G, Wham, M, Hendry, R, Scott-Brown, J, Begg, C, Hinds, C, Ho, AYW, Horby, PW, Knight, J, Ling, L, Maslove, D, McAuley, D, Montgomery, H, Openshaw, PJM, Summers, C, Walsh, T, Armstrong, L, Bates, H, Dooks, E, Farquhar, F, Hairsine, B, McParland, C, Packham, S, Alldis, Z, Lain, RA-C, Bibi, F, Biddle, J, Blow, S, Bolton, M, Borra, C, Bowles, R, Burton, M, Choudhury, Y, Collier, D, Cox, A, Easthope, A, Ebano, P, Fotiadis, S, Gurasashvili, J, Halls, R, Hartridge, P, Kallon, D, Kassam, J, Lancoma-Malcolm, I, Matharu, M, May, P, Mitchelmore, O, Newman, T, Patel, M, Pheby, J, Pinzuti, I, Prime, Z, Prysyazhna, O, Shiel, J, Taylor, M, Tierney, C, Wood, S, Zak, A, Zongo, O, Forsey, M, Nicholson, A, Riches, J, Vertue, M, Wasson, C, Finn, S, Green, J, Collins, E, King, B, Grauslyte, L, Hussain, M, Pogreban, T, Rosaroso, L, Salciute, E, Franke, G, Wong, J, George, A, Akeroyd, L, Bano, S, Bromley, M, Gurr, L, Lawton, T, Morgan, J, Sellick, K, Warren, D, Wilkinson, B, McGowan, J, Ledgard, C, Stacey, A, Pye, K, Bellwood, R, Bentley, M, Loosley, R, McGuinness, H, Tench, H, Wolf-Roberts, R, Gibson, S, Lyle, A, McNeela, F, Radhakrishnan, J, Hughes, A, Ali, A, Brady, M, Dale, S, Dance, A, Gledhill, L, Greig, J, Hanson, K, Holdroyd, K, Home, M, Kelly, D, Kitson, R, Matapure, L, Melia, D, Mellor, S, Nortcliffe, T, Pinnell, J, Robinson, M, Shaw, L, Shaw, R, Thomis, L, Wilson, A, Wood, T, Bayo, L-A, Merwaha, E, Ishaq, T, Hanley, S, Antcliffe, D, Banach, D, Brett, S, Coghlan, P, Fernandez, Z, Gordon, A, Rojo, R, Arias, SS, Templeton, M, Jha, R, Krishnamurthy, V, Lim, L, Bi, R, Scholefield, B, Ashton, L, Williams, A, Cheyne, C, Saunderson, A, Allan, A, Anderson, F, Kaye, C, Liew, J, Medhora, J, Scott, T, Trumper, E, Botello, A, Polgarova, P, Stroud, K, Meaney, E, Jones, M, Ng, A, Agrawal, S, Pathan, N, White, D, Daubney, E, Elston, K, Parker, R, Reddy, A, Turner-Bone, I, Wilding, L, Harding, P, Jacob, R, Jones, C, Denmade, C, Croft, M, White, I, Griffin, D, Muchenje, N, Mupudzi, M, Partridge, R, Conyngham, J-A, Thomas, R, Wright, M, Corral, MA, Bastion, V, Clarke, D, David, B, Kent, H, Lorusso, R, Lubimbi, G, Murdoch, S, Penacerrada, M, Thomas, A, Valentine, J, Vochin, A, Wulandari, R, Djeugam, B, Dawson, J, Garrioch, S, Tolson, M, Aldridge, J, Martins, LGDA, Carungcong, J, Beavis, S, Dale, K, Gascoyne, R, Hawes, J, Pritchard, K, Stevenson, L, Whileman, A, Cowley, A, Highgate, J, Crawley, R, Crew, A, Cunningham, M, Daniels, A, Harrison, L, Hope, S, Inweregbu, K, Jones, S, Lancaster, N, Matthews, J, Wray, G, Benham, L, Bradshaw, Z, Brown, J, Caswell, M, Melling, S, Preston, S, Slawson, N, Stoddard, E, Warden, S, Combes, E, Joefield, T, Monnery, S, Beech, V, Trotman, S, Hopkins, B, Scriven, J, Thrasyvoulou, L, Willis, H, Anderson, S, Birch, J, Hammerton, K, O'Leary, R, Abernathy, C, Foster, L, Gratrix, A, Martinson, V, Parkinson, P, Stones, E, Carbral-Ortega, L, Kapoor, R, Loader, D, Castle, K, Brandwood, C, Smith, L, Clark, R, Birchall, K, Kolakaluri, L, Baines, D, Sukumaran, A, Mapfunde, I, Meredith, M, Morris, L, Ryan, L, Clark, A, Sampson, J, Peters, C, Dent, M, Langley, M, Wei, S, Andrew, A, Chablani, M, Kirkby, A, Netherton, K, Bates, M, Dasgin, J, Gill, J, Nilsson, A, Apetri, E, Basikolo, C, Blackledge, B, Catlow, L, Charles, B, Doonan, R, Harris, J, Harvey, A, Horner, D, Knowles, K, Lomas, D, Lyons, C, Marsden, T, McLaughlan, D, McMorrow, L, Pendlebury, J, Perez, J, Poulaka, M, Proudfoot, N, Slaughter, M, Slevin, K, Thomas, V, Walker, D, Michael, A, Collis, M, Clark, M, Coulding, M, Jude, E, McCormick, J, Mercer, O, Potla, D, Rehman, H, Savill, H, Turner, V, Davey, M, Golden, D, Seaman, R, Hunt, J, Dearden, J, Dobson, E, Mulcahy, M, Munt, S, O'Connor, G, Philbin, J, Rishton, C, Tully, R, Winnard, S, Cagova, L, Fofano, A, Garner, L, Holcombe, H, Mepham, S, Mitchell, AM, Mwaura, L, Praman, K, Zamikula, J, Bercades, G, Brealey, D, Hass, I, MacCallum, N, Martir, G, Raith, E, Reyes, A, Smyth, D, Taylor, A, Hughes, RA, Thomas, H, Rees, A, Duskova, M, Phipps, J, Brooks, S, Edwards, M, Alexander, P, Allen, S, Bradley-Potts, J, Brantwood, C, Egan, J, Felton, T, Padden, G, Ward, L, Moss, S, Glasgow, S, Beesley, K, Board, S, Kubisz-Pudelko, A, Lewis, A, Perry, J, Pippard, L, Wood, D, Buckley, C, Brown, A, Gregory, J, O'Connell, S, Smith, T, Belagodu, Z, Fuller, B, Gherman, A, Olufuwa, O, Paramsothy, R, Stuart, C, Oakley, N, Kamundi, C, Tyl, D, Collins, K, Silva, P, Taylor, J, King, L, Coates, C, Crowley, M, Wakefield, P, Beadle, J, Johnson, L, Sargeant, J, Anderson, M, Jardine, C, Williams, D, Parris, V, Quaid, S, Watson, E, Melville, J, Naisbitt, J, Joseph, R, Lazo, M, Walton, O, Neal, A, Hill, M, Kannan, T, Wild, L, Allan, E, Darlington, K, Davies, F, Easton, J, Kumar, S, Lean, R, Menzies, D, Pugh, R, Qiu, X, Davies, L, Williams, H, Scanlon, J, Davies, G, Mackay, C, Lewis, J, Rees, S, Coetzee, S, Gales, A, Raj, M, Sell, C, Langton, H, Watters, M, Novis, C, Arbane, G, Bociek, A, Campos, S, Grau, N, Jones, TO, Lim, R, Marotti, M, Whitton, C, Barron, A, Collins, C, Kaul, S, Passmore, H, Prendergast, C, Reed, A, Rogers, P, Shokkar, R, Woodruff, M, Middleton, H, Polgar, O, Nolan, C, Thwaites, V, Mahay, K, Sri-Chandana, C, Scherewode, J, Stephenson, L, Marsh, S, Bancroft, H, Bellamy, M, Carmody, M, Daglish, J, Moore, F, Rhodes, J, Sangombe, M, Kadiri, S, Ayers, A, Harrison, W, North, J, Cavazza, A, Cockrell, M, Corcoran, E, Depante, M, Finney, C, Jerome, E, McPhail, M, Nayak, M, Noble, H, O'Reilly, K, Pappa, E, Saha, R, Saha, S, Smith, J, Knighton, A, Gill, M, Paul, P, Ratnam, V, Shelton, S, Wynter, I, Baptista, D, Crowe, R, Fernandes, R, Herdman-Grant, R, Joseph, A, Loveridge, A, McKenley, I, Morino, E, Naranjo, A, Simms, R, Sollesta, K, Swain, A, Venkatesh, H, Khera, J, Fox, J, Barber, R, Hewitt, C, Hilldrith, A, Jackson-Lawrence, K, Shepardson, S, Wills, M, Butler, S, Tavares, S, Cunningham, A, Hindale, J, Arif, S, George, L, Twiss, S, Wright, D, Holland, M, Keenan, N, Lyons, M, Wassall, H, Marsh, C, Mahenthran, M, Carter, E, Kong, T, Adanini, O, Bhatia, N, Msiska, M, Mew, L, Mwaura, E, Williams, F, Wren, L, Sutherland, S-B, Battle, C, Brinkworth, E, Harford, R, Murphy, C, Newey, L, Rees, T, Arnold, S, Hardy, J, Houlden, H, Moncur, E, Tariq, A, Tucci, A, Convery, K, Fottrell-Gould, D, Hudig, L, Keshet-Price, J, Randell, G, Stammers, K, Abdelrazik, M, Bakthavatsalam, D, Elhassan, M, Ganesan, A, Haldeos, A, Moreno-Cuesta, J, Purohit, D, Vincent, R, Xavier, K, Rohit, K, Alasdair, F, Saleem, M, David, C, Jenkins, S, Lamond, Z, Wall, A, Reynolds, J, Campbell, H, Thompsom, M, Dodds, S, Duffy, S, Butcher, D, O'Sullivan, S, Butterworth-Cowin, N, Deacon, B, Hibbert, M, Pothecary, C, Tetla, D, Woodford, C, Durga, L, Kennard-Holden, G, de Gordoa, LO-R, Peasgood, E, Phillips, C, Skinner, D, Gaylard, J, Mullan, D, Newman, J, Davies, E, Roche, L, Sathe, S, Brimfield, L, Daly, Z, Pogson, D, Rose, S, Collins, A, Khaliq, W, Gude, ET, Allen, L, Beranova, E, Crisp, N, Deery, J, Hazelton, T, Knight, A, Price, C, Tilbey, S, Turki, S, Turney, S, Giles, J, Booth, S, Bell, G, English, K, Katary, A, Wilcox, L, Campbell, R, Clarke, N, Whiteside, J, Mascarenhas, M, Donaldson, A, Matheson, J, Barrett, F, O'Hara, M, O'Keefe, L, Bradley, C, Walker, R, Maynard, V, Patel, T, Smith, M, Kazi, A, Hartley, J, Dykes, J, Hijazi, M, Keith, S, Khan, M, Ryan-Smith, J, Springle, P, Truman, N, Saad, S, Coleman, D, Fine, C, Matt, R, Gay, B, Dalziel, J, Ali, S, Goodchild, D, Harling, R, Bhatterjee, R, Goddard, W, Davison, C, Duberly, S, Hargreaves, J, Bolton, R, Verlander, M, Blackman, H, Creagh-Brown, B, Donlon, S, Michalak-Glinska, N, Mtuwa, S, Pristopan, V, Salberg, A, Smith, E, Stone, S, Piercy, C, Verula, J, Burda, D, Montaser, R, Harden, L, Mayangao, I, Marriott, C, Bradley, P, Harris, C, Cooper, J, Finch, C, Liderth, S, Quinn, A, Waddington, N, Fidler, K, Tagliavini, E, Donnelly, K, Abel, L, Brett, M, Digby, B, Gemmell, L, Hornsby, J, MacGoey, P, O'Neil, P, Price, R, Rodden, N, Rooney, K, Sundaram, R, Thomson, N, Flanagan, R, Hughes, G, Latham, S, McKenna, E, Anderson, J, Hull, R, Rhead, K, Branney, D, Frankham, J, Pitts, S, White, N, Cristiano, D, Dormand, N, Farzad, Z, Gummadi, M, Liyanage, K, Patel, BV, Salmi, S, Sloane, G, Varghese, M, Zborowski, AC, Bean, S, Burt, K, Spivey, M, Eastgate-Jackson, C, Filipe, H, Martin, D, Maharajh, A, Garcia, SM, De Neef, M, Lynch, C, Howe, GS, Singh, J, Turner, K, Ellis, H, Stroud, N, Cherian, S, Cutler, S, Heron, AE, Roynon-Reed, A, Williams, G, Richards, O, Cheema, Y, Ahmad, N, Barker, J, Bauchmuller, K, Bird, S, Cawthron, K, Harrington, K, Jackson, Y, Kibutu, F, Lenagh, B, Masuko, S, Raithatha, A, Wiles, M, Willson, J, Newell, H, Lye, A, Nwafor, L, Jarman, C, Rowland-Jones, S, Foote, D, Cole, J, Watson, J, Hesseldon, L, Macharia, I, Chetam, L, Ford, A, Housley, K, Milner, L, Hanratty, H, Trower, H, Phillips, P, Oxspring, S, Donne, B, Bevan, E, Trodd, D, Watson, G, Brown, CW, Bunni, L, Jennings, C, Latif, M, Marshall, R, Subramanian, G, Bandla, N, Gellamucho, M, Davies, M, Trim, F, Eapen, B, Ahmed, C, Baines, B, Clamp, S, Colley, J, Haq, R, Hayes, A, Hulme, J, Joseph, S, Kumar, R, Maqsood, Z, Purewal, M, Chandler, B, Elliott, K, Mallinson, J, Turnbull, A, Dent, K, Horsley, E, Akhtar, MN, Pearson, S, Potoczna, D, Spencer, S, Blakemore, H, Borislavova, B, Faulkner, B, Gendall, E, Goff, E, Hayes, K, Thomas, M, Worner, R, Smith, K, Stephens, D, Delgado, CC, Dawson, D, Ding, L, Durrant, G, Ezeobu, O, Farnell-Ward, S, Harrison, A, Kanu, R, Leaver, S, Maccacari, E, Manna, S, Saluzzio, RP, Queiroz, J, Samakomva, T, Sicat, C, Texeira, J, Da Gloria, EF, Lisboa, A, Rawlins, J, Mathew, J, Kinch, A, Hurt, WJ, Shah, N, Clark, V, Thanasi, M, Yun, N, Patel, K, Crickmore, V, Debreceni, G, Wilkins, J, Nicol, L, Burn, I, Hambrook, G, Manso, K, Penn, R, Shanmugasundaram, P, Tebbutt, J, Thornton, D, Rostron, A, Roy, A, Woods, L, Cornell, S, Wakinshaw, F, Rogerson, K, Jarmain, J, Anderson, P, Archer, K, Austin, K, Davis, C, Durie, A, Kelsall, O, Thrush, J, Vigurs, C, Wood, H-L, Tranter, H, Cowley, N, McAlindon, M, Digby, S, Low, E, Morgan, A, Cother, N, Rankin, T, Clayton, S, McCurdy, A, Allibone, S, Mary-Genetu, R, Patel, A, Mac, A, Murphy, A, Mahjoob, P, Nazari, R, Worsley, L, Fagan, A, Ali, IMA, Beaumont, K, Blunt, M, Coton, Z, Curgenven, H, Elsaadany, M, Fernandes, K, Ally, SM, Rangarajan, H, Sarathy, V, Selvanayagam, S, Vedage, D, White, M, Fernandez-Roman, J, Hamilton, DO, Johnson, E, Johnston, B, Martinez, ML, Mulla, S, Shaw, D, Waite, AAC, Waugh, V, Welters, ID, Williams, K, Bemand, T, Black, E, Dela Rosa, A, Howle, R, Jhanji, S, Baikady, RR, Tatham, KC, Thomas, B, Halkes, M, Mercer, P, Thornton, L, West, J, Baird, T, Ruddy, J, Reece-Anthony, R, Birt, M, Cowton, A, Kay, A, Kent, M, Potts, K, Wilkinson, A, Naylor, S, Brown, E, Purvis, S, Davies, R, Duffin, D, Hill, H, Player, B, Thomas, E, Beith, CM, Black, K, Clements, S, Morrison, A, Strachan, D, Clarkson, M, D'Sylva, S, Norman, K, Coventry, T, Fowler, S, McGregor, A, Brady, A, Chan, R, McIvor, S, Prady, H, Whittle, H, Mathew, B, Clapham, M, Harper, R, Poultney, U, Rice, P, Mutch, R, Baird, Y, Butler, A, Chadbourn, I, Folkes, L, Fox, H, Gardner, A, Gomez, R, Hobden, G, King, K, Margarson, M, Martindale, T, Meadows, E, Raynard, D, Thirlwall, Y, Helm, D, Margalef, J, Greer, S, Shuker, K, Smuts, S, Duffield, J, Smith, O, Mallon, L, Claire, W, Birkinshaw, I, Carter, J, Howard, K, Ingham, J, Joy, R, Pearson, H, Roche, S, Scott, Z, Knights, E, Price, A, Thorpe, C, Abraheem, A, Bamford, P, Cawley, K, Dunmore, C, Faulkner, M, Girach, R, Jeffrey, H, Jones, R, London, E, Nagra, I, Nasir, F, Sainsbury, H, Smedley, C, Khade, R, Sundar, A, Tsinaslanidis, G, Behan, T, Burnett, C, Hatton, J, Heeney, E, Mitra, A, Newton, M, Pollard, R, Stead, R, Bough, L, Goodsell, J, Tutton, R, Williams, P, Williams, S, Winter-Goodwin, B, Auld, F, Donnachie, J, Edmond, I, Prentice, L, Runciman, N, Salutous, D, Symon, L, Todd, A, Turner, P, Short, A, Sweeney, L, Murdoch, E, Senaratne, D, Burns, K, Higham, A, Anderson, T, Hawcutt, D, O'Malley, L, Rad, L, Rogers, N, Saunderson, P, Allison, KS, Afolabi, D, Whitbread, J, Jones, D, Dore, R, Lankester, L, Nikitas, N, Wells, C, Stowe, B, Spencer, K, Cathcart, S, Duffy, K, Puxty, A, Puxty, K, Turner, L, Ireland, J, Semple, G, Barry, P, Hilltout, P, Evitts, J, Tyler, A, Waldron, J, Irvine, V, Shelley, B, Akinkugbe, O, Bamford, A, Beech, E, Belfield, H, Bell, M, Davies, C, Jones, GAL, McHugh, T, Meghari, H, O'Neill, L, Peters, MJ, Ray, S, Tomas, AL, Gorman, C, Gupta, A, Timlick, E, Brady, R, Bonner, S, Hugill, K, Jones, J, Liggett, S, Bashyal, A, Davidson, N, Hutton, P, McKechnie, S, Wilson, J, Flint, N, Rekha, P, Hales, D, Cruz, C, Gopal, S, Harris, N, Lake, V, Metherell, S, Radford, E, Clement, I, Gulati, A, Hays, C, Webster, K, Hudson, A, Webster, A, Stephenson, E, McCormack, L, Slater, V, Nixon, R, Hanson, H, Fearby, M, Kelly, S, Bridgett, V, Robinson, P, Almaden-Boyle, C, Austin, P, Cabrelli, L, Casey, M, Chapman, S, Whyte, C, Brayne, A, Fisher, E, Jackson, P, Kaye, D, Love, N, Parkin, J, Tuckey, V, van Koutrik, L, Carter, S, Andrew, B, Findlay, L, Adams, K, Bruce, M, Connolly, K, Duncan, T, Michael, HT, Lindergard, G, Hey, S, Fox, C, Alfonso, J, Durrans, LJ, Guerin, J, Hruska, M, Eltayeb, A, Lamb, T, Hodgkiss, T, Cooper, L, Rothwell, J, Dennis, C, Srikaran, S, Sukha, A, Davies, K, O'Brien, L, Omar, Z, Perkins, E, Lewis, T, Sutherland, I, Brooke, H, Buckley, S, Suarez, JC, Charlesworth, R, Hansson, K, Norris, J, Poole, A, Sandhu, R, Sloan, B, Smithson, E, Thirumaran, M, Wagstaff, V, Metcalfe, A, Camsooksai, J, Humphrey, C, Wadams, B, Death, Y, Adams, C, Agasou, A, Arden, T, Bowes, A, Boyle, P, Beekes, M, Button, H, Capps, N, Carnahan, M, Carter, A, Childs, D, Donaldson, D, Hard, K, Hurford, F, Hussain, Y, Javaid, A, Jose, S, Leigh, M, Martin, T, Millward, H, Motherwell, N, Rikunenko, R, Stickley, J, Summers, J, Ting, L, Tivenan, H, Tonks, L, Wilcox, R, Bokhari, M, Lucas, R, McCormick, W, Ritzema, J, Sanderson, A, Wild, H, Baxter, N, Henderson, S, Kennedy-Hay, S, Rooney, L, Sim, M, McCreath, G, Brunton, M, Caterson, J, Coles, H, Frise, M, Rai, SG, Keating, L, Tilney, E, Bartley, S, Bhuie, P, Downes, C, Holding, K, Riches, K, Hilton, M, Hayman, M, Subramanian, D, Daniel, P, Zitter, L, Benyon, S, Marriott, S, Park, L, Keenan, S, Gordon, E, Quinn, H, Baines, K, Andrew, G, Barclay, L, Callaghan, M, Clark, S, Hope, D, Marshall, L, McCulloch, C, Briton, K, Singleton, J, Birch, S, Simpson, K, Craig, J, Demetriou, C, Eckbad, C, Hierons, S, Howie, L, Mitchard, S, Ramos, L, Serrano-Ruiz, A, White, K, Kelly, F, Amin, V, Anastasescu, E, Anumakonda, V, Karthik, K, Kausar, R, Reid, K, Imeson-Wood, J, Bellini, A, Bryant, J, Pickard, A, Roe, N, Sowter, J, Howlett, A, Criste, K, Cusack, R, Golder, K, Golding, H, Jones, O, Leggett, S, Male, M, Marani, M, Prager, K, Williams, T, Roberts, B, Salmon, K, Gondo, P, Hadebe, B, Kayani, A, Masunda, B, Ahmed, A, Morris, A, Jakkula, S, Long, K, Whiteley, S, Wilby, E, Ogg, B, Moultrie, S, Odam, M, Bewley, J, Garland, Z, Grimmer, L, Gumbrill, B, Sweet, K, Webster, D, Efford, G, Bennett, S, Goodwin, E, Jackson, M, Kent, A, Tibke, C, Woodyatt, W, Zaki, A, Daniel, A, Finn, J, Bremmer, P, Allan, J, Geary, T, Houston, G, Meikle, A, O'Brien, P, Bell, D, Boyle, R, Douglas, K, Glass, L, Lee, E, Lennon, L, Rattray, A, Charnock, R, McFarland, D, Cosgrove, D, Attwood, B, Parsons, P, Carmody, S, Oblak, M, Popescu, M, Thankachen, M, Baruah, R, Morris, S, Ferguson, S, Shepherd, A, Altabaibeh, A, Alvaro, A, Gilbert, K, Ma, L, Mostoles, L, Parmar, C, Jetha, C, Booker, L, Pratley, A, Cosier, T, Millen, G, Schumacher, N, Weston, H, Rand, J, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Docherty, AB, Dunning, J, Filipe, ADS, Fletcher, T, Green, CA, Harrison, EM, Hiscox, JA, Ijaz, S, Khoo, S, Lim, WS, Mentzer, AJ, Merson, L, Noursadeghi, M, Moore, SC, Palmarini, M, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Robertson, DL, Sancho-Shimizu, V, Scott, JT, de Silva, T, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Tedder, RS, Thomson, EC, Thompson, AAR, Thwaites, RS, Turtle, LCW, Gupta, RK, Palmieri, C, Swann, OV, Zambon, M, Dumas, M-E, Griffin, JL, Takats, Z, Chechi, K, Andrikopoulos, P, Osagie, A, Olanipekun, M, Liggi, S, Lewis, MR, Correia, GDS, Sands, CJ, Takis, P, Maslen, L, Greenhalf, W, Shaw, V, McDonald, SE, Ahmed, KA, Armstrong, JA, Ashworth, M, Asiimwe, IG, Bakshi, S, Barlow, SL, Booth, L, Brennan, B, Bullock, K, Catterall, BWA, Clark, JJ, Clarke, EA, Cox, H, Dincarslan, O, Dunn, C, Dyer, P, Elliott, A, Evans, A, Finch, L, Fisher, LWS, Foster, T, Garcia-Dorival, I, Gunning, P, Hartley, C, Jensen, RL, Jones, CB, Jones, TR, Khandaker, S, Kiy, RT, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, LA, Mancini, M, McDonald, S, McEvoy, L, McLauchlan, J, Metelmann, S, Miah, NS, Middleton, J, Mitchell, J, Murphy, EG, Penrice-Randal, R, Pilgrim, J, Prince, T, Reynolds, W, Ridley, PM, Sales, D, Shaw, VE, Shears, RK, Small, B, Subramaniam, KS, Szemiel, A, Taggart, A, Tanianis-Hughes, J, Trochu, E, van Tonder, L, Wilcock, E, Zhang, JE, Flaherty, L, Maziere, N, Cass, E, Carracedo, AD, Carlucci, N, Holmes, A, Massey, H, Murphy, L, Wrobel, N, McCafferty, S, Morrice, K, MacLean, A, Armstrong, R, Boz, C, Coutts, A, Cullum, L, Day, N, Donnelly, L, Duncan, E, Fawkes, A, Finernan, P, Gilchrist, T, Golightly, A, Hafezi, K, Law, D, Law, R, Law, S, Macgillivray, L, Maclean, A, Mal, H, Mcmaster, E, Meikle, J, Oosthuyzen, W, Paterson, T, Stenhouse, A, Swets, M, Szoor-McElhinney, H, Taneski, F, Wackett, T, Ward, M, Weaver, J, Coyle, J, Gallagher, B, Lidstone-Scott, R, Hamilton, D, Schon, K, Furlong, A, Biggs, H, Griffiths, F, Andrews, E, Brickell, K, Smyth, M, Carson, G, Hardwick, H, Donohue, C, Initiative, CHG, Team, AC, Grp, NS-CS, Force, HCT, Task, HGC, FHoGID, RegCOVID, P-PredictUs, SeroCOVID, CRiPSI, Team, GHR, Working, UCLAHATLASDM, COVID-19 Host Genetics initiative, including authors, Amsterdam Neuroscience - Complex Trait Genetics, Complex Trait Genetics, Internal Medicine, Epidemiology, Oral and Maxillofacial Surgery, UK Research and Innovation, NIHR, UKRI MRC COVID-19 Rapid Response Call, Niemi, Mari E. K., Karjalainen, Juha, Liao, Rachel G., Neale, Benjamin M., Daly, Mark, Ganna, Andrea, Pathak, Gita A., Andrews, Shea J., Kanai, Masahiro, Veerapen, Kumar, Fernandez-Cadenas, Israel, Schulte, Eva C., Striano, Pasquale, Marttila, Minttu, Minica, Camelia, Marouli, Eirini, Karim, Mohd Anisul, Wendt, Frank R., Savage, Jeanne, Sloofman, Laura, Butler-Laporte, Guillaume, Kim, Han-Na, Kanoni, Stavroula, Okada, Yukinori, Byun, Jinyoung, Han, Younghun, Uddin, Mohammed Jashim, Smith, George Davey, Willer, Cristen J., Buxbaum, Joseph D., Mehtonen, Juha, Finucane, Hilary, Cordioli, Mattia, Martin, Alicia R., Zhou, Wei, Pasaniuc, Bogdan, Julienne, Hanna, Aschard, Hugue, Shi, Huwenbo, Yengo, Loic, Polimanti, Renato, Ghoussaini, Maya, Schwartzentruber, Jeremy, Dunham, Ian, Chwialkowska, Karolina, Francescatto, Margherita, Trankiem, Amy, Balaconis, Mary K., Davis, Lea, Lee, Sulggi, Priest, Jame, Renieri, Alessandra, Sankaran, Vijay G., van Heel, David, Deelen, Patrick, Richards, J. Brent, Nakanishi, Tomoko, Biesecker, Le, Kerchberger, V. Eric, Baillie, J. Kenneth, Mari, Francesca, Bernasconi, Anna, Baillie, Stefano Ceri, Canakoglu, Arif, Wolford, Brooke, Faucon, Annika, Dutta, Atanu Kumar, Schurmann, Claudia, Harry, Emi, Birney, Ewan, Nguyen, Huy, Nasir, Jamal, Kaunisto, Mari, Solomonson, Matthew, Dueker, Nicole, Vadgama, Nirmal, Limou, Sophie, Rahmouni, Souad, Mbarek, Hamdi, Darwish, Dima, Uddin, Md Mesbah, Albertos, Raquel, Pérez-Tur, Jordi, Li, Ruolin, Folkersen, Lasse, Moltke, Ida, Koelling, Nil, Teumer, Alexander, Kousathanas, Athanasio, Utrilla, Alicia, Verdugo, Ricardo A., Zárate, Ruth, Medina-Gómez, Carolina, Gómez-Cabrero, David, Carnero-Montoro, Elena, Cadilla, Carmen L., Moreno-Estrada, André, Garmendia, Adriana, Moya, Leire, Sedaghati-Khayat, Bahar, Boua, Palwendé Romuald, Favé, Marie-Julie, Francioli, Laurent, Lemaçon, Audrey, Migeotte, Isabelle, Patel, Sanjay, Varnai, Reka, Szentpeteri, Jozsef L., Sipeky, Csilla, Colombo, Francesca, von Hohenstaufen, Kathrin, Lio, Pietro, Vallerga, Costanza, Wang, Qingbo, Tanigawa, Yosuke, Im, Hogune, Han, Chulho, Song, Han, Lim, Jiwoo, Lee, Younhe, Kim, Sugyeong, Im, Sangyoon, Atanasovska, Biljana, Ahmad, Hajar Fauzan, Boer, Cindy, Jansen, Philip, Franke, Lude, Kaja, Elżbieta, Pasko, Dorota, Kennis-Szilagyi, Ingrid, Kornilov, Sergey A., Prijatelj, Vid, Prokić, Ivana, Sivanadhan, Ilangkumaran, Perumal, Sarala, Esmaeeli, Sahar, Pearson, Nathaniel M., Auton, Adam, Shelton, Janie F., Shastri, Anjali J., Filshtein-Sonmez, Teresa, Coker, Daniella, Symons, Antony, Esparza-Gordillo, Jorge, Aslibekyan, Stella, O’Connell, Jared, Ye, Chelsea, Weldon, Catherine H., Perera, Minoli, O’Leary, Kevin, Tuck, Matthew, O’Brien, Travi, Meltzer, David, O’Donnell, Peter, Nutescu, Edith, Yang, Guang, Alarcon, Cristina, Herrmann, Stefanie, Mazurek, Sophia, Banagan, Jeff, Hamidi, Zacharia, Barbour, April, Raffat, Noora, Moreno, Diana, Friedman, Paula, Ferwerda, Bart, van de Beek, Diederik, Brouwer, Matthijs C., Vlaar, Alexander P. J., Wiersinga, W. Joost, Posthuma, Danielle, Tissink, Elleke, Koos Zwinderman, A. H., Uffelmann, Emil, van Agtmael, Michiel, Algera, Anne Geke, van Baarle, Frank, Bax, Diane, Beudel, Martijn, Jan Bogaard, Harm, Bomers, Marije, Bonta, Peter I., Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Bugiani, Marianna, Bulle, Esther, Chouchane, Osoul, Cloherty, Alex, Dongelmans, Dave, Elbers, Paul, Fleuren, Luca, Geerlings, Suzanne, Geerts, Bart, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hafkamp, Florianne, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Marku, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Koning, Rutger, van Mourik, Niel, Nellen, Jeannine, Nossent, Esther J., Paulus, Frederique, Peters, Edgar, van der Poll, Tom, Preckel, Bennedikt, Prins, Jan M., Raasveld, Jorinde, Reijnders, Tom, Schinkel, Michiel, Schultz, Marcus J., Schuurman, Alex, Sigaloff, Kim, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa, van der Valk, Marc, Veelo, Denise, de Vries, Heder, van Vugt, Michèle, Wouters, Dorien, Minnaar, René P., Kromhout, Adrie, van Uffelen, Kees W. J., Wolterman, Ruud A., Roberts, Genevieve, Park, Danny, Ball, Catherine A., Coignet, Marie, Mccurdy, Shannon, Knight, Spencer, Partha, Raghavendran, Rhead, Brooke, Zhang, Miao, Berkowitz, Nathan, Gaddis, Michael, Noto, Keith, Ruiz, Luong, Pavlovic, Milo, Hong, Eurie L., Rand, Kristin, Girshick, Ahna, Guturu, Harendra, Baltzell, Asher Haug, Guntz, Julien, Beguin, Yve, Pigazzini, Sara, Nkambule, Lindokuhle, Bouysran, Youssef, Busson, Adeline, Peyrassol, Xavier, Wilkin, Françoise, Pichon, Bruno, Smits, Guillaume, Vandernoot, Isabelle, Goffard, Jean-Christophe, Georges, Michel, Moutschen, Michel, Misset, Benoit, Darcis, Gille, Guiot, Julien, Jadot, Laurent, Azarzar, Samira, Dellot, Patricia, Gofflot, Stéphanie, Claassen, Sabine, Bertrand, Axelle, Parzibut, Gille, Clarinval, Mathilde, Moermans, Catherine, Malaise, Olivier, El Kandoussi, Kamilia, Thonon, Raphaël, Huynen, Pascale, Mesdagh, Alyssia, Melo, Sofia, Jacques, Nicola, Di Valentin, Emmanuel, Giroule, Françoi, Collignon, Alice, Radermecker, Coraline, Lebrun, Marielle, Perée, Hélène, Latour, Samuel, Barada, Olivia, Sanchez, Judit, Josse, Claire, Boujemla, Bouchra, Meunier, Margot, Mariavelle, Emeline, Anania, Sandy, Gazon, Hélène, Juszczak, Danusia, Fadeur, Marjorie, Camby, Séverine, Meuris, Christelle, Thys, Marie, Jacques, Jessica, Henket, Monique, Léonard, Philippe, Frippiat, Frederic, Giot, Jean-Baptiste, Sauvage, Anne-Sophie, Von Frenckell, Christian, Mni, Myriam, Wéry, Marie, Staderoli, Alicia, Belhaj, Yasmine, Lambermont, Bernard, Morrison, David R., Mooser, Vincent, Forgetta, Vincenzo, Li, Rui, Ghosh, Biswarup, Laurent, Laetitia, Belisle, Alexandre, Henry, Danielle, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Vulesevic, Branka, Bouab, Meriem, Guzman, Charlotte, Petitjean, Loui, Tselios, Chri, Xue, Xiaoqing, Afilalo, Jonathan, Afilalo, Marc, Oliveira, Maureen, Brenner, Bluma, Brassard, Nathalie, Durand, Madeleine, Schurr, Erwin, Lepage, Pierre, Ragoussis, Jianni, Auld, Daniel, Chassé, Michaël, Kaufmann, Daniel E., Lathrop, G. Mark, Adra, Darin, Davis, Lea K., Cox, Nancy J., Below, Jennifer E., Sealock, Julia M., Faucon, Annika B., Shuey, Megan M., Polikowsky, Hannah G., Petty, Lauren E., Shaw, Douglas M., Chen, Hung-Hsin, Zhu, Wanying, Ludwig, Kerstin U., Schröder, Julia, Maj, Carlo, Rolker, Selina, Nöthen, Markus M., Fazaal, Julia, Keitel, Verena, Jensen, Björn-Erik Ole, Feldt, Torsten, Kurth, Ingo, Marx, Nikolau, Dreher, Michael, Pink, Isabell, Cornberg, Marku, Illig, Thoma, Lehmann, Clara, Schommers, Philipp, Augustin, Max, Rybniker, Jan, Knopp, Lisa, Eggermann, Thoma, Volland, Sonja, Altmüller, Janine, Berger, Marc M., Brenner, Thorsten, Hinney, Anke, Witzke, Oliver, Bals, Robert, Herr, Christian, Ludwig, Nicole, Walter, Jörn, Fuchsberger, Christian, Pattaro, Cristian, De Grandi, Alessandro, Pramstaller, Peter, Emmert, David, Melotti, Roberto, Foco, Luisa, Mascalzoni, Deborah, Gögele, Martin, Domingues, Francisco, Hicks, Andrew, Gignoux, Christopher R., Wicks, Stephen J., Crooks, Kristy, Barnes, Kathleen C., Daya, Michelle, Shortt, Jonathan, Rafaels, Nichola, Chavan, Sameer, Goldstein, David B., Kiryluk, Krzysztof, Sengupta, Soumitra, Chung, Wendy, Reilly, Muredach P., Khan, Atla, Wang, Chen, Povysil, Gundula, Bhardwaj, Nitin, Gharavi, Ali G., Ionita-Laza, Iuliana, Shang, Ning, O’Byrne, Sheila M., Nandakumar, Renu, Menon, Amritha, So, Yat S., Hod, Eldad, Pendrick, Danielle, Park, Soo-Kyung, Kim, Hyung-Lae, Kang, Chang Kyung, Lee, Hyo-Jung, Song, Kyoung-Ho, Jae Yoon, Kyung, Paik, Nam-Jong, Seok, Woojin, Yoon, Heejun, Joo, Eun-Jeong, Chang, Yoosoo, Ryu, Seungho, Park, Wan Beom, Su Park, Jeong, Un Park, Kyoung, Ham, Sin Young, Jung, Jongtak, Kim, Eu Suk, Kim, Hong Bin, Ellinghaus, David, Degenhardt, Frauke, Cáceres, Mario, Juzenas, Simona, Lenz, Tobias L., Albillos, Agustín, Julià, Antonio, Heidecker, Bettina, Garcia, Federico, Kurth, Florian, Tran, Florian, Hanses, Frank, Zoller, Heinz, Holter, Jan C., Fernández, Javier, Sander, Leif Erik, Rosenstiel, Philip, Koehler, Philipp, de Cid, Rafael, Asselta, Rosanna, Schreiber, Stefan, Hehr, Ute, Prati, Daniele, Baselli, Guido, Valenti, Luca, Bujanda, Lui, Banales, Jesus M., Duga, Stefano, D’Amato, Mauro, Romero-Gómez, Manuel, Buti, Maria, Invernizzi, Pietro, Franke, Andre, Hov, Johannes R., Karlsen, Tom H., Folseraas, Trine, Maya-Miles, Dougla, Teles, Ana, Azuure, Clinton, Wacker, Eike Matthia, Uellendahl-Werth, Florian, Elabd, Hesham, Arora, Jatin, Lerga-Jaso, Jon, Wienbrandt, Lar, Rühlemann, Malte Christoph, Wendorff, Mareike, Vadla, May Sissel, Lenning, Ole Bernt, Özer, Onur, Myhre, Ronny, Raychaudhuri, Soumya, Tanck, Anja, Gassner, Christoph, Hemmrich-Stanisak, Georg, Kässens, Jan, Figuera Basso, Maria E., Schulzky, Martin, Wittig, Michael, Braun, Nicole, Wesse, Tanja, Albrecht, Wolfgang, Yi, Xiaoli, Ortiz, Aaron Blandino, Chercoles, Adolfo Garrido, Ruiz, Agustín, Mantovani, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Barreira, Ana, Lleo, Ana, Kildal, Anders Benjamin, Glück, Andrea, Nolla, Anna Carrera, Latiano, Anna, Dyrhol-Riise, Anne Ma, Muscatello, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Karina, Banasik, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Bellinghausen, Carla, Ferrando, Carlo, Quereda, Carmen, Skurk, Carsten, Thibeault, Charlotte, Spinner, Christoph D., Lange, Christoph, Hu, Cinzia, Cappadona, Claudio, Bianco, Cristiana, Sancho, Cristina, Lihaug Hoff, Dag Arne, Galimberti, Daniela, Jiménez, David, Pestaña, David, Toapanta, David, Azzolini, Elena, Scarpini, Elio, Helbig, Elisa T., Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Navas, Enrique, Arana, Eunate, Sánchez, Félix García, Ceriotti, Ferruccio, Malvestiti, Francesco, Mesonero, Francisco, Pezzoli, Gianni, Lamorte, Giuseppe, Neb, Holger, My, Ilaria, Hernández, Isabel, de Rojas, Itziar, Galván-Femenia, Iván, Heyckendorf, Jan, Badia, Joan Ramon, Schneider, Jochen, Goikoetxea, Josune, Kraft, Julia, Müller, Karl Erik, Gaede, Karoline I., Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lar, Izquierdo-Sanchez, Laura, Sumoy, Lauro, Lippert, Lena J., Terranova, Leonardo, Garbarino, Lucia, Téllez, Lui, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, Manoli, Gutiérrez-Stampa, María A., Vehreschild, Maria J. G. T., Marquié, Marta, Castoldi, Massimo, Cecconi, Maurizio, Boada, Mercè, Seilmaier, Michael J., Mazzocco, Michela, Rodríguez-Gandía, Miguel, Ayo, Natale Imaz, Blay, Natalia, Martínez, Nilda, Cornely, Oliver A., Palmieri, Orazio, Tentorio, Paolo, Rodrigues, Pedro M., España, Pedro P., Hoffmann, Per, Bacher, Petra, Suwalski, Phillip, de Pablo, Raúl, Nieto, Rosa, Badalamenti, Salvatore, Ciesek, Sandra, Bombace, Sara, Wilfling, Sibylle, Brunak, Søren, Heilmann-Heimbach, Stefanie, Ripke, Stephan, Bahmer, Thoma, Landmesser, Ulf, Protzer, Ulrike, Rimoldi, Valeria, Skogen, Vegard, Andrade, Victor, Moreno, Victor, Poller, Wolfgang, Farre, Xavier, Wang, Xiaomin, Khodamoradi, Yascha, Karadeniz, Zehra, de Salazar, Adolfo, Palom, Adriana, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Zanella, Alberto, Bandera, Alessandra, Nebel, Almut, Biondi, Andrea, Caballero-Garralda, Andrea, Gori, Andrea, Lind, Andrea, Fracanzani, Anna Ludovica, Peschuck, Anna, Pesenti, Antonio, de la Horra, Carmen, Milani, Chiara, Paccapelo, Cinzia, Angelini, Claudio, Cea, Cristina, Muñiz-Diaz, Eduardo, Sandoval, Elena, Calderón, Enrique J., Solligård, Erik, Aziz, Fátima, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Blasi, Francesco, Medrano, Francisco J., Rodriguez-Frias, Francisco, Müller, Fredrik, Grasselli, Giacomo, Costantino, Giorgio, Cardamone, Giulia, Foti, Giuseppe, Matullo, Giuseppe, Kurihara, Hayato, Afset, Jan Egil, Damås, Jan Kristian, Ampuero, Javier, Martín, Javier, Erdmann, Jeanette, Bergan, Jona, Goerg, Siegfried, Ferrusquía-Acosta, Jose, Quero, Jose Hernández, Delgado, Juan, Guerrero, Juan M., Risnes, Kari, Bettini, Laura Rachele, Moreira, Leticia, Gustad, Lise Tuset, Santoro, Luigi, Scudeller, Luigia, Riveiro-Barciela, Mar, Schaefer, Marco, Carrabba, Maria, Valsecchi, Maria G., Hernandez-Tejero, María, Acosta-Herrera, Marialbert, D’Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Ciccarelli, Michele, Bocciolone, Monica, Miozzo, Monica, Chueca, Natalia, Montano, Nicola, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Castro, Pedro, Ferrer, Ricard, Gualtierotti, Roberta, Gallego-Durán, Rocío, Morilla, Rubén, Haider, Sammra, Marsal, Sara, Aneli, Serena, Pelusi, Serena, Bosari, Silvano, Aliberti, Stefano, Dudman, Susanne, Zheng, Tenghao, Pumarola, Toma, Cejudo, Trinidad Gonzalez, Monzani, Valter, Friaza, Vicente, Peter, Wolfgang, Dopazo, Ximo, May, Sandra, Grimsrud, Marit M., Gudbjartsson, Daniel F., Stefansson, Kari, Sulem, Patrick, Sveinbjornsson, Gardar, Melsted, Pall, Norddahl, Gudmundur, Swerford Moore, Kristjan Helgi, Thorsteinsdottir, Unnur, Holm, Hilma, Alarcón-Riquelme, Marta E., Bernardo, David, Martínez-Bueno, Manuel, Rello, Silvia Rojo, Magi, Reedik, Milani, Lili, Metspalu, Andre, Laisk, Triin, Läll, Kristi, Lepamets, Maarja, Esko, Tõnu, Reimann, Ene, Naaber, Paul, Laane, Edward, Pesukova, Jaana, Peterson, Pärt, Kisand, Kai, Tabri, Jekaterina, Allos, Raili, Hensen, Kati, Starkopf, Joel, Ringmets, Inge, Tamm, Anu, Kallaste, Anne, Alavere, Helene, Metsalu, Kristjan, Puusepp, Mairo, Kristiansson, Kati, Koskelainen, Sami, Perola, Marku, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Rivolta, Carlo, Bochud, Pierre-Yve, Bibert, Stéphanie, Boillat, Noémie, Nussle, Semira Gonseth, Albrich, Werner, Quinodoz, Mathieu, Kamdar, Dhryata, Suh, Noémie, Neofytos, Dionysio, Erard, Véronique, Voide, Cathy, Bochud, P. Y., Rivolta, C., Bibert, S., Quinodoz, M., Kamdar, D., Neofytos, D., Erard, V., Voide, C., Friolet, R., Vollenweider, P., Pagani, J. L., Oddo, M., zu Bentrup, F. Meyer, Conen, A., Clerc, O., Marchetti, O., Guillet, A., Guyat-Jacques, C., Foucras, S., Rime, M., Chassot, J., Jaquet, M., Viollet, R. Merlet, Lannepoudenx, Y., Portopena, L., Desgranges, F., Filippidis, P., Guéry, B., Haefliger, D., Kampouri, E. E., Manuel, O., Munting, A., Papadimitriou-Olivgeris, M., Regina, J., Rochat-Stettler, L., Suttels, V., Tadini, E., Tschopp, J., Van Singer, M., Viala, B., Boillat-Blanco, N., Brahier, T., Hügli, O., Meuwly, J. Y., Pantet, O., Nussle, S. Gonseth, Bochud, M., D’Acremont, V., Younes, S. Estoppey, Albrich, W. C., Suh, N., Cerny, A., O’Mahony, L., von Mering, C., Frischknecht, M., Kleger, G. -R., Filipovic, M., Kahlert, C. R., Wozniak, H., Negro, T. Rochat, Pugin, J., Bouras, K., Knapp, C., Egger, T., Perret, A., Montillier, P., di Bartolomeo, C., Barda, B., Carreras, Anna, Galván-Femenía, Iván, Farré, Xavier, Cortés, Beatriz, Mercader, Josep Maria, Guindo-Martinez, Marta, Torrents, David, Garcia-Aymerich, Judith, Castaño-Vinyals, Gemma, Dobaño, Carlota, Gori, Marco, Mondelli, Mario Umberto, Castelli, Francesco, Vaghi, Massimo, Rusconi, Stefano, Montagnani, Francesca, Bargagli, Elena, Franchi, Federico, Mazzei, Maria Antonietta, Cantarini, Luca, Tacconi, Danilo, Feri, Marco, Scala, Raffaele, Spargi, Genni, Nencioni, Cesira, Bandini, Maria, Caldarelli, Gian Piero, Spagnesi, Maurizio, Canaccini, Anna, Ognibene, Agostino, D’Arminio Monforte, Antonella, Girardis, Massimo, Antinori, Andrea, Francisci, Daniela, Schiaroli, Elisabetta, Scotton, Pier Giorgio, Panese, Sandro, Scaggiante, Renzo, Monica, Matteo Della, Capasso, Mario, Fiorentino, Giuseppe, Castori, Marco, Aucella, Filippo, Di Biagio, Antonio, Masucci, Luca, Valente, Serafina, Mandalà, Marco, Zucchi, Patrizia, Giannattasio, Ferdinando, Coviello, Domenico A., Mussini, Cristina, Bosio, Giancarlo, Tavecchia, Luisa, Crotti, Lia, Rizzi, Marco, La Rovere, Maria Teresa, Sarzi-Braga, Simona, Bussotti, Maurizio, Ravaglia, Sabrina, Artuso, Rosangela, Perrella, Antonio, Romani, Davide, Bergomi, Paola, Catena, Emanuele, Vincenti, Antonella, Ferri, Claudio, Grassi, Davide, Pessina, Gloria, Tumbarello, Mario, Di Pietro, Massimo, Sabrina, Ravaglia, Luchi, Sauro, Barbieri, Chiara, Acquilini, Donatella, Andreucci, Elena, Paciosi, Francesco, Segala, Francesco Vladimiro, Tiseo, Giusy, Falcone, Marco, Lista, Mirjam, Poscente, Monica, De Vivo, Oreste, Petrocelli, Paola, Guarnaccia, Alessandra, Baroni, Silvia, Perticaroli, Valentina, Furini, Simone, Dei, Simona, Benetti, Elisa, Picchiotti, Nicola, Sanarico, Maurizio, Ceri, Stefano, Pinoli, Pietro, Raimondi, Francesco, Biscarini, Filippo, Stella, Alessandra, Bergomi, Mattia, Zguro, Kristina, Capitani, Katia, Tanfoni, Marco, Fallerini, Chiara, Daga, Sergio, Baldassarri, Margherita, Fava, Francesca, Frullanti, Elisa, Valentino, Floriana, Doddato, Gabriella, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Lo Rizzo, Caterina, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Di Sarno, Laura, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Iuso, Nicola, Inchingolo, Gabriele, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Mantovani, Stefania, Ludovisi, Serena, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Siano, Matteo, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Zanelli, Giacomo, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennet, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Guerrini, Susanna, Conticini, Edoardo, Frediani, Bruno, Spertilli, Chiara, Donati, Alice, Guidelli, Luca, Corridi, Marta, Croci, Leonardo, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Verzuri, Agnese, Anemoli, Valentina, Pancrazi, Alessandro, Lorubbio, Maria, Merlini, Esther, Miraglia, Federica Gaia, Venturelli, Sophie, Cossarizza, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Andretta, Francesca, Gatti, Francesca, Parisi, Saverio Giuseppe, Baratti, Stefano, Piscopo, Carmelo, Russo, Roberta, Andolfo, Immacolata, Iolascon, Achille, Carella, Massimo, Merla, Giuseppe, Squeo, Gabriella Maria, Raggi, Pamela, Marciano, Carmen, Perna, Rita, Bassetti, Matteo, Sanguinetti, Maurizio, Giorli, Alessia, Salerni, Lorenzo, Parravicini, Pierpaolo, Menatti, Elisabetta, Trotta, Tullio, Coiro, Gabriella, Lena, Fabio, Martinelli, Enrico, Mancarella, Sandro, Gabbi, Chiara, Maggiolo, Franco, Ripamonti, Diego, Bachetti, Tiziana, Suardi, Claudia, Parati, Gianfranco, Bottà, Giordano, Di Domenico, Paolo, Rancan, Ilaria, Bianchi, Francesco, Colombo, Riccardo, van Heel, David A., Hunt, Karen A., Trembath, Richard C., Huang, Qin Qin, Martin, Hilary C., Mason, Dan, Trivedi, Bhavi, Wright, John, Finer, Sarah, Griffiths, Christopher J., Akhtar, Shaheen, Anwar, Mohammad, Arciero, Elena, Ashraf, Samina, Breen, Gerome, Chung, Raymond, Curtis, Charles J., Chowdhury, Maharun, Colligan, Grainne, Deloukas, Pano, Durham, Ceri, Griffiths, Chri, Hurles, Matt, Hussain, Shapna, Islam, Kamrul, Khan, Ahsan, Khan, Amara, Lavery, Cath, Lee, Sang Hyuck, Lerner, Robin, Macarthur, Daniel, Maclaughlin, Bev, Martin, Hilary, Miah, Shefa, Newman, Bill, Safa, Nishat, Tahmasebi, Farah, Smith, Albert V., Boughton, Andrew P., Li, Kevin W., Lefaive, Jonathon, Annis, Aubrey, Jannes, Cinthia E., Krieger, Jose E., Pereira, Alexandre C., Velho, Mariliza, Marques, Emanuelle, Lima, Isabella Ramo, Tada, Mauricio Teruo, Valino, Karina, Mccarthy, Mark, Rosenberger, Carrie, Lee, Jong Eun, Chang, Diana, Hammer, Christian, Hunkapiller, Julie, Mahajan, Anubha, Pendergrass, Sarah, Sucheston-Campbell, Lara, Yaspan, Brian, Lee, Hyun Soo, Shin, Eunsoon, Jang, Hye Yoon, Kim, Sunmie, Kym, Sungmin, Kim, Yeon-Sook, Jeong, Hyeongseok, Kwon, Ki Tae, Kim, Shin-Woo, Kim, Jin Yong, Jang, Young Rock, Kim, Hyun ah, Lee, Ji Yeon, Lee, Jeong Eun, Lee, Shinwon, Choe, Kang-Won, Kang, Yu Min, Jee, Sun Ha, Jung, Keum Ji, Parikh, Victoria, Ashley, Euan, Wheeler, Matthew, Rivas, Manuel, Bustamante, Carlo, Pinksy, Benjamin, Febbo, Phillip, Farh, Kyle, Schroth, Gary P., Desouza, Franci, Dalton, Karen, Christle, Jeff, Deboever, Christopher, Szalma, Sándor, Rubinacci, Simone, Delaneau, Olivier, Gorzynski, John, de Jong, Hannah, Sutton, Shirley, Youlton, Nathan, Joshi, Ruchi, Jimenez-Morales, David, Hughes, Christopher, Amar, David, Ioannidis, Alex, Hershman, Steve, Kirillova, Anna, Seo, Kinya, Huang, Yong, Shoura, Massa, Hammond, Nathan, Watson, Nathaniel, Raja, Archana, Huang, Chunhong, Sahoo, Malaya, Wang, Hannah, Zhen, Jimmy, Rakitko, Alexander, Ilinsky, Valery, Yermakovich, Danat, Popov, Iaroslav, Chernitsov, Alexander, Kovalenko, Elena, Krasnenko, Anna, Plotnikov, Nikolay, Stetsenko, Ivan, Kim, Anna, Cirulli, Elizabeth T., Schiabor Barrett, Kelly M., Bolze, Alexandre, White, Simon, Washington, Nicole L., Lu, James T., Riffle, Stephen, Tanudjaja, Francisco, Wang, Xueqing, Ramirez, Jimmy M., Leonetti, Nicole, Sandoval, Efren, Neveux, Iva, Dabe, Shaun, Grzymski, Joseph J., Esteban Miñano, Juan Ignacio, Aguirre, Luis A., López-Collazo, Eduardo, de la Mata Pazos, Manuel, Cerrato, Luciano, Lozano-Rodríguez, Roberto, Avendaño-Ortiz, José, Arcos, Verónica Terrón, Montalbán-Hernández, Karla Marina, Quiroga, Jaime Valentín, Pascual-Iglesias, Alejandro, Maroun-Eid, Charbel, Martín-Quirós, Alejandro, Namkoong, Ho, Imoto, Seiya, Katayama, Kazuhiko, Fukunaga, Koichi, Kitagawa, Yuko, Sato, Toshiro, Hasegawa, Naoki, Kumanogoh, Atsushi, Kimura, Akinori, Ai, Masumi, Tokunaga, Katsushi, Kanai, Takanori, Miyano, Satoru, Ogawa, Seishi, Edahiro, Ryuya, Sonehara, Kyuto, Shirai, Yuya, Ishii, Makoto, Kabata, Hiroki, Masaki, Katsunori, Kamata, Hirofumi, Ikemura, Shinnosuke, Chubachi, Shotaro, Okamori, Satoshi, Terai, Hideki, Tanaka, Hiromu, Morita, Atsuho, Lee, Ho, Asakura, Takanori, Sasaki, Junichi, Morisaki, Hiroshi, Uwamino, Yoshifumi, Nanki, Kosaku, Mikami, Yohei, Tomono, Kazunori, Kato, Kazuto, Matsuda, Fumihiko, Takahashi, Meiko, Hizawa, Nobuyuki, Takeda, Yoshito, Hirata, Haruhiko, Shiroyama, Takayuki, Miyawaki, Satoru, Suzuki, Ken, Maeda, Yuichi, Nii, Takuro, Noda, Yoshimi, Niitsu, Takayuki, Adachi, Yuichi, Enomoto, Takatoshi, Amiya, Saori, Hara, Reina, Takahashi, Kunihiko, Anzai, Tatsuhiko, Hasegawa, Takanori, Ito, Satoshi, Koike, Ryuji, Endo, Akifumi, Uchimura, Yuji, Miyazaki, Yasunari, Honda, Takayuki, Tateishi, Tomoya, Tohda, Shuji, Ichimura, Naoya, Sonobe, Kazunari, Sassa, Chihiro, Nakajima, Jun, Nannya, Yasuhito, Omae, Yosuke, Takahashi, Kazuhisa, Harada, Norihiro, Hiki, Makoto, Takagi, Haruhi, Nakamura, Ai, Tagaya, Etsuko, Kawana, Masatoshi, Arimura, Ken, Ishiguro, Takashi, Takayanagi, Noboru, Isono, Taisuke, Takaku, Yotaro, Takano, Kenji, Anan, Ryusuke, Nakajima, Yukiko, Nakano, Yasushi, Nishio, Kazumi, Ueda, Soichiro, Hayashi, Reina, Tateno, Hiroki, Hase, Isano, Yoshida, Shuichi, Suzuki, Shoji, Mitamura, Keiko, Saito, Fumitake, Ueda, Tetsuya, Azuma, Masanori, Nagasaki, Tadao, Yasui, Yoshinori, Hasegawa, Yoshinori, Mutoh, Yoshikazu, Yoshiyama, Takashi, Shoko, Tomohisa, Kojima, Mitsuaki, Adachi, Tomohiro, Ishikawa, Motonao, Takahashi, Kenichiro, Watanabe, Kazuyoshi, Manabe, Tadashi, Ito, Fumimaro, Fukui, Takahiro, Funatsu, Yohei, Koh, Hidefumi, Hirai, Yoshihiro, Kawashima, Hidetoshi, Narita, Atsuya, Niwa, Kazuki, Sekikawa, Yoshiyuki, Saito, Fukuki, Yoshiya, Kazuhisa, Yoshihara, Tomoyuki, Suzuki, Yusuke, Nakayama, Sohei, Masuzawa, Keita, Nishi, Koichi, Nishitsuji, Masaru, Tani, Maiko, Inoue, Takashi, Hirano, Toshiyuki, Kobayashi, Keigo, Miyazawa, Naoki, Kimura, Yasuhiro, Sado, Reiko, Ogura, Takashi, Kitamura, Hideya, Murohashi, Kota, Nakachi, Ichiro, Baba, Rie, Arai, Daisuke, Fuke, Satoshi, Saito, Hiroshi, Kuwahara, Naota, Fujiwara, Akiko, Okada, Takenori, Baba, Tomoya, Noda, Junya, Mashimo, Shuko, Yagi, Kazuma, Shiomi, Tetsuya, Hashiguchi, Mizuha, Odani, Toshio, Mochimaru, Takao, Oyamada, Yoshitaka, Mori, Nobuaki, Izumi, Namiki, Nagata, Kaoru, Taki, Reiko, Murakami, Koji, Yamada, Mitsuhiro, Sugiura, Hisatoshi, Hayashi, Kentaro, Shimizu, Tetsuo, Gon, Yasuhiro, Fujitani, Shigeki, Tsuchida, Tomoya, Yoshida, Toru, Kagaya, Takashi, Kita, Toshiyuki, Sakagami, Satoru, Kimizuka, Yoshifumi, Kawana, Akihiko, Nakamura, Yoshihiko, Ishikura, Hiroyasu, Takata, Tohru, Kikuchi, Takahide, Taniyama, Daisuke, Nakamura, Morio, Kodama, Nobuhiro, Kaneyama, Yasunari, Maeda, Shunsuke, Nagasaki, Yoji, Okamoto, Masaki, Ishihara, Sayoko, Ito, Akihiro, Chihara, Yusuke, Takeuchi, Mayumi, Onoi, Keisuke, Hashimoto, Naozumi, Wakahara, Keiko, Ando, Akira, Masuda, Makoto, Wakabayashi, Aya, Watanabe, Hiroki, Sageshima, Hisako, Nakada, Taka-Aki, Abe, Ryuzo, Shimada, Tadanaga, Kawamura, Kodai, Ichikado, Kazuya, Nishiyama, Kenta, Yamasaki, Masaki, Hashimoto, Satoru, Kusaka, Yu, Ohba, Takehiko, Isogai, Susumu, Takada, Minoru, Kanda, Hidenori, Komase, Yuko, Sano, Fumiaki, Asano, Koichiro, Oguma, Tsuyoshi, Harada, Masahiro, Takahashi, Takeshi, Shibusawa, Takayuki, Abe, Shinji, Kono, Yuta, Togashi, Yuki, Izumo, Takehiro, Inomata, Minoru, Awano, Nobuyasu, Ogawa, Shinichi, Ogata, Tomouki, Ishihara, Shoichiro, Kanehiro, Arihiko, Ozaki, Shinji, Fuchimoto, Yasuko, Kitagawa, Yuichiro, Yoshida, Shozo, Ogura, Shinji, Nishiyama, Kei, Yoshida, Kousuke, Beppu, Satoru, Fukuyama, Satoru, Eriguchi, Yoshihiro, Yonekawa, Akiko, Inoue, Yoshiaki, Yamagata, Kunihiro, Chiba, Shigeru, Narumoto, Osamu, Nagai, Hideaki, Ooshima, Nobuharu, Motegi, Mitsuru, Sagara, Hironori, Tanaka, Akihiko, Ohta, Shin, Shibata, Yoko, Tanino, Yoshinori, Sato, Yuki, Yamada, Yuichiro, Hashino, Takuya, Shinoki, Masato, Iwagoe, Hajime, Imamura, Tomonori, Umeda, Akira, Shimada, Hisato, Endo, Mayu, Hayashi, Shinichi, Takahashi, Mai, Nakano, Shigefumi, Yatomi, Masakiyo, Maeno, Toshitaka, Ishii, Tomoo, Utsugi, Mitsuyoshi, Ono, Akihiro, Kanaoka, Kensuke, Ihara, Shoichi, Komuta, Kiyoshi, Boezen, Marike, Claringbould, Annique, Lopera, Esteban, Warmerdam, Robert, Vonk, Judith. M., van Blokland, Irene, Lanting, Pauline, Ori, Anil P. S., Obeidat, Ma’En, Hernández Cordero, Ana I., Sin, Don D., Bossé, Yohan, Joubert, Philippe, Hao, Ke, Nickle, David, Timens, Wim, van den Berge, Maarten, Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Perez, Emma F., Zöllner, Sebastian, Wang, Jiongming, Beck, Andrew, Sloofman, Laura G., Ascolillo, Steven, Sebra, Robert P., Collins, Brett L., Levy, Te, Sealfon, Stuart C., Jordan, Daniel M., Thompson, Ryan C., Gettler, Kyle, Chaudhary, Kumardeep, Belbin, Gillian M., Preuss, Michael, Hoggart, Clive, Choi, Sam, Underwood, Slayton J., Salib, Irene, Britvan, Bari, Keller, Katherine, Tang, Lara, Peruggia, Michael, Hiester, Liam L., Niblo, Kristi, Aksentijevich, Alexandra, Labkowsky, Alexander, Karp, Avromie, Zlatopolsky, Menachem, Zyndorf, Marissa, Charney, Alexander W., Beckmann, Noam D., Schadt, Eric E., Abul-Husn, Noura S., Cho, Judy H., Itan, Yuval, Kenny, Eimear E., Loos, Ruth J. F., Nadkarni, Girish N., Do, Ron, O’Reilly, Paul, Huckins, Laura M., Ferreira, Manuel A. R., Abecasis, Goncalo R., Leader, Joseph B., Cantor, Michael N., Justice, Anne E., Carey, Dave J., Chittoor, Geetha, Josyula, Navya Shilpa, Kosmicki, Jack A., Horowitz, Julie E., Baras, Ari, Gass, Matthew C., Yadav, Ashish, Mirshahi, Tooraj, Jan Hottenga, Jouke, Bartels, Meike, de Geus, Eco J. C., Nivard, Michel G., Verma, Anurag, Ritchie, Marylyn D., Rader, Daniel, Li, Binglan, Verma, Shefali S., Lucas, Anastasia, Bradford, Yuki, Zara, Federico, Salpietro, Vincenzo, Scala, Marcello, Iacomino, Michele, Scudieri, Paolo, Bocciardi, Renata, Minetti, Carlo, Riva, Antonella, Vari, Maria Stella, Rahier, Jean-Françoi, Giorgio, Elisa, Carli, Diana, Louis, Edouad, Bulik, Cynthia M., Landén, Mikael, Brusco, Alfredo, Ferrero, Giovanni Battista, Madia, Francesca, Fundín, Bengt, Ismail, Said I., Saad, Chadi, Al-Sarraj, Yaser, Badji, Radja Messai, Al-Muftah, Wadha, Al Thani, Asma, Afifi, Nahla, Klovins, Jani, Rovite, Vita, Rescenko, Raimond, Peculis, Raiti, Ustinova, Monta, Zeberg, Hugo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklo, Johnson, Ruth, Geschwind, Daniel H., Freimer, Nelson, Butte, Manish J., Ding, Yi, Chiu, Alec, Chang, Timothy S., Boutros, Paul, Moutsianas, Louka, Caulfield, Mark J., Scott, Richard H., Walker, Susan, Stuckey, Alex, Odhams, Christopher A., Rhodes, Daniel, Fowler, Tom, Rendon, Augusto, Chan, Georgia, Arumugam, Prabhu, Karczewski, Konrad J., Wilson, Daniel J., Spencer, Chris A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikola, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Seed, Cotton, Daly, Mark J., Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicola, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Soranzo, Nicole, Zhao, Jing Hua, Danesh, John, Di Angelantonio, Emanuele, Butterworth, Adam S., Sun, Yan V., Huffman, Jennifer E., Cho, Kelly, O’Donnell, Christopher J., Tsao, Phil, Gaziano, J. Michael, Peloso, Gina, Ho, Yuk-Lam, Mian, Michael, Scaggiante, Federica, Chang, Xiao, Glessner, Joseph R., Hakonarson, Hakon, Mcguigan, Peter J., Prockter Moore, Luke Stephen, Vizcaychipi, Marcela Paola, Hall, Kathryn, Campbell, Andy, Nichol, Ailstair, Ward, Geraldine, Page, Valerie Joan, Semple, Malcolm G., Adeniji, Kayode, Agranoff, Daniel, Agwuh, Ken, Ail, Dhiraj, Aldera, Erin L., Alegria, Ana, Angus, Brian, Ashish, Abdul, Atkinson, Dougal, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Barrett, Nichola, Bassford, Christopher, Basude, Sneha, Baxter, David, Beadsworth, Michael, Bernatoniene, Jolanta, Berridge, John, Best, Nicola, Bothma, Pieter, Chadwick, David, Brittain-Long, Robin, Bulteel, Naomi, Burden, Tom, Burtenshaw, Andrew, Caruth, Vikki, Chambler, Duncan, Chee, Nigel, Child, Jenny, Chukkambotla, Srikanth, Clark, Tom, Collini, Paul, Cosgrove, Catherine, Cupitt, Jason, Cutino-Moguel, Maria-Teresa, Dark, Paul, Dawson, Chri, Dervisevic, Samir, Donnison, Phil, Douthwaite, Sam, Drummond, Andrew, Durand, Ingrid, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Eziefula, Chi, Fegan, Christopher, Finn, Adam, Fullerton, Duncan, Garg, Sanjeev, Garg, Atul, Gkrania-Klotsas, Effrossyni, Godden, Jo, Goldsmith, Arthur, Graham, Clive, Hardy, Elaine, Hartshorn, Stuart, Harvey, Daniel, Havalda, Peter, Hawcutt, Daniel B., Hobrok, Maria, Hodgson, Luke, Hormis, Anil, Jacobs, Michael, Jain, Susan, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Kegg, Stephen, Kelsey, Michael, Kendall, Jason, Kerrison, Caroline, Kerslake, Ian, Koch, Oliver, Koduri, Gouri, Koshy, George, Laha, Shondipon, Laird, Steven, Larkin, Susan, Leiner, Tama, Lillie, Patrick, Limb, Jame, Linnett, Vanessa, Little, Jeff, Lyttle, Mark, Macmahon, Michael, Macnaughton, Emily, Mankregod, Ravish, Masson, Huw, Matovu, Elijah, Mccullough, Katherine, Mcewen, Ruth, Meda, Manjula, Mills, Gary H., Minton, Jane, Ward, Karl, Mirfenderesky, Mariyam, Mohandas, Kavya, Mok, Quen, Moon, Jame, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Mortimore, Katherine, Moses, Samuel, Mpenge, Mbiye, Mulla, Rohinton, Murphy, Michael, Nagel, Megan, Nagarajan, Thapa, Nelson, Mark, O’Shea, Matthew K., Otahal, Igor, Ostermann, Marlie, Pais, Mark, Panchatsharam, Selva, Papakonstantinou, Danai, Paraiso, Hassan, Patel, Brij, Pattison, Natalie, Pepperell, Justin, Peters, Mark, Phull, Mandeep, Pintus, Stefania, Pooni, Jagtur Singh, Post, Frank, Price, David, Prout, Rachel, Rae, Nikola, Reschreiter, Henrik, Reynolds, Tim, Richardson, Neil, Roberts, Mark, Roberts, Devender, Rose, Alistair, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shah, Aarti, Shanmuga, Prad, Sharma, Anil, Shawcross, Anna, Sizer, Jeremy, Shankar-Hari, Manu, Smith, Richard, Snelson, Catherine, Spittle, Nick, Staines, Nikki, Stambach, Tom, Stewart, Richard, Subudhi, Pradeep, Szakmany, Tama, Tatham, Kate, Thomas, Jo, Thompson, Chri, Thompson, Robert, Tridente, Ascanio, Tupper-Carey, Darell, Twagira, Mary, Ustianowski, Andrew, Vallotton, Nick, Vincent-Smith, Lisa, Visuvanathan, Shico, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Walden, Andrew, Welters, Ingeborg, Whitehouse, Tony, Whittaker, Paul, Whittington, Ashley, Papineni, Padmasayee, Wijesinghe, Meme, Williams, Martin, Wilson, Lawrence, Cole, Sarah, Winchester, Stephen, Wiselka, Martin, Wolverson, Adam, Wooton, Daniel G., Workman, Andrew, Yates, Bryan, Young, Peter, Beale, Rupert, Bretherick, Andrew D., Clohisey, Sara, Fourman, Max Head, Furniss, Jame, Gountouna, Elvina, Grimes, Graeme, Haley, Chri, Harrison, David, Hayward, Caroline, Keating, Sean, Klaric, Lucija, Klenerman, Paul, Law, Andy, Meynert, Alison M., Millar, Jonathan, Pairo-Castineira, Erola, Parkinson, Nichola, Ponting, Chris P., Porteous, David J., Rawlik, Konrad, Richmond, Anne, Rowan, Kathy, Russell, Clark D., Shen, Xia, Shih, Barbara, Tenesa, Albert, Vitart, Veronique, Wang, Bo, Wilson, James F., Wu, Yang, Yang, Jian, Yang, Zhijian, Zechner, Marie, Zhai, Ranran, Zheng, Chenqing, Norman, Lisa, Pius, Riinu, Drake, Thomas M., Fairfield, Cameron J., Knight, Stephen R., Mclean, Kenneth A., Murphy, Derek, Shaw, Catherine A., Dalton, Jo, Girvan, Michelle, Saviciute, Egle, Roberts, Stephanie, Harrison, Janet, Marsh, Laura, Connor, Marie, Halpin, Sophie, Jackson, Clare, Gamble, Carrol, Leeming, Gary, Law, Andrew, Wham, Murray, Hendry, Ro, Scott-Brown, Jame, Begg, Colin, Hinds, Charle, Wai Ho, Antonia Ying, Horby, Peter W., Knight, Julian, Ling, Lowell, Maslove, David, Mcauley, Danny, Montgomery, Hugh, Nichol, Alistair, Openshaw, Peter J. M., Summers, Charlotte, Walsh, Timothy, Armstrong, Lisa, Bates, Hayley, Dooks, Emma, Farquhar, Fiona, Hairsine, Brigid, Mcparland, C., Packham, Sophie, Alldis, Zoe, Astin-Chamberlain, Raine, Bibi, Fatima, Biddle, Jack, Blow, Sarah, Bolton, Matthew, Borra, Catherine, Bowles, Ruth, Burton, Maudrian, Choudhury, Yasmin, Collier, David, Cox, Amber, Easthope, Amy, Ebano, Patrizia, Fotiadis, Stavro, Gurasashvili, Jana, Halls, Rosslyn, Hartridge, Pippa, Kallon, Delordson, Kassam, Jamila, Lancoma-Malcolm, Ivone, Matharu, Maninderpal, May, Peter, Mitchelmore, Oliver, Newman, Tabitha, Patel, Mital, Pheby, Jane, Pinzuti, Irene, Prime, Zoe, Prysyazhna, Oleksandra, Shiel, Julian, Taylor, Melanie, Tierney, Carey, Wood, Suzanne, Zak, Anne, Zongo, Olivier, Forsey, Miranda, Nicholson, Anne, Riches, Joanne, Vertue, Mark, Wasson, Christopher, Finn, Stephanie, Green, Jackie, Collins, Erin, King, Bernadette, Grauslyte, Lina, Hussain, Musarat, Pogreban, Tatiana, Rosaroso, Lace, Salciute, Erika, Franke, George, Wong, Joanna, George, Aparna, Akeroyd, Louise, Bano, Shereen, Bromley, Matt, Gurr, Lucy, Lawton, Tom, Morgan, Jame, Sellick, Kirsten, Warren, Deborah, Wilkinson, Brian, Mcgowan, Janet, Ledgard, Camilla, Stacey, Amelia, Pye, Kate, Bellwood, Ruth, Bentley, Michael, Loosley, Ronda, Mcguinness, Heather, Tench, Helen, Wolf-Roberts, Rebecca, Gibson, Sian, Lyle, Amanda, Mcneela, Fiona, Radhakrishnan, Jayachandran, Hughes, Alistair, Ali, Asifa, Brady, Megan, Dale, Sam, Dance, Annalisa, Gledhill, Lisa, Greig, Jill, Hanson, Kathryn, Holdroyd, Kelly, Home, Marie, Kelly, Diane, Kitson, Ro, Matapure, Lear, Melia, Deborah, Mellor, Samantha, Nortcliffe, Tonicha, Pinnell, Jez, Robinson, Matthew, Shaw, Lisa, Shaw, Ryan, Thomis, Lesley, Wilson, Alison, Wood, Tracy, Bayo, Lee-Ann, Merwaha, Ekta, Ishaq, Tahira, Hanley, Sarah, Antcliffe, David, Banach, Dorota, Brett, Stephen, Coghlan, Phoebe, Fernandez, Ziortza, Gordon, Anthony, Rojo, Roceld, Arias, Sonia Sousa, Templeton, Maie, Jha, Rajeev, Krishnamurthy, Vinodh, Lim, Lai, Bi, Rehana, Scholefield, Barney, Ashton, Lydia, Williams, Alison, Cheyne, Claire, Saunderson, Anne, Allan, Angela, Anderson, Felicity, Kaye, Callum, Liew, Jade, Medhora, Jasmine, Scott, Teresa, Trumper, Erin, Botello, Adriana, Polgarova, Petra, Stroud, Katerina, Meaney, Eoghan, Jones, Megan, Ng, Anthony, Agrawal, Shruti, Pathan, Nazima, White, Deborah, Daubney, Esther, Elston, Kay, Parker, Robert, Reddy, Amie, Turner-Bone, Ian, Wilding, Laura, Harding, Peter, Jacob, Reni, Jones, Cathy, Denmade, Craig, Croft, Maria, White, Ian, Lim, Li, Griffin, Denise, Muchenje, Nycola, Mupudzi, Mcdonald, Partridge, Richard, Conyngham, Jo-Anna, Thomas, Rachel, Wright, Mary, Corral, Maria Alvarez, Bastion, Victoria, Clarke, Daphene, David, Beena, Kent, Harriet, Lorusso, Rachel, Lubimbi, Gamu, Murdoch, Sophie, Penacerrada, Melchizedek, Thomas, Alastair, Valentine, Jennifer, Vochin, Ana, Wulandari, Retno, Djeugam, Brice, Dawson, Joy, Garrioch, Sweyn, Tolson, Melanie, Aldridge, Jonathan, de Almeida Martins, Laura Gome, Carungcong, Jaime, Beavis, Sarah, Dale, Katie, Gascoyne, Rachel, Hawes, Joanne, Pritchard, Kelly, Stevenson, Lesley, Whileman, Amanda, Cowley, Anne, Highgate, Judith, Crawley, Rikki, Crew, Abigail, Cunningham, Mishell, Daniels, Allison, Harrison, Laura, Hope, Susan, Inweregbu, Ken, Jones, Sian, Lancaster, Nicola, Matthews, Jamie, Nicholson, Alice, Wray, Gemma, Benham, Leonie, Bradshaw, Zena, Brown, Joanna, Caswell, Melanie, Melling, Sarah, Preston, Stephen, Slawson, Nicola, Stoddard, Emma, Warden, Scott, Combes, Edward, Joefield, Teishel, Monnery, Sonja, Beech, Valerie, Trotman, Sallyanne, Hopkins, Bridget, Scriven, Jame, Thrasyvoulou, Laura, Willis, Heather, Anderson, Susan, Birch, Janine, Collins, Emma, Hammerton, Kate, O’Leary, Ryan, Abernathy, Caroline, Foster, Louise, Gratrix, Andrew, Martinson, Vicky, Parkinson, Priyai, Stones, Elizabeth, Carbral-Ortega, Llucia, Kapoor, Ritoo, Loader, David, Castle, Karen, Brandwood, Craig, Smith, Lara, Clark, Richard, Birchall, Katie, Kolakaluri, Laurel, Baines, Deborah, Sukumaran, Anila, Mapfunde, Isheunesu, Meredith, Megan, Morris, Lucy, Ryan, Lucy, Clark, Amy, Sampson, Julia, Peters, Cecilia, Dent, Martin, Langley, Margaret, Ashraf, Saima, Wei, Shuying, Andrew, Angela, Chablani, Manish, Kirkby, Amy, Netherton, Kimberley, Bates, Michelle, Dasgin, Jo, Gill, Jaspret, Nilsson, Annette, Apetri, Elena, Basikolo, Cathrine, Blackledge, Bethan, Catlow, Laura, Charles, Bethan, Doonan, Reece, Harris, Jade, Harvey, Alice, Horner, Daniel, Knowles, Karen, Lee, Stephanie, Lomas, Diane, Lyons, Chloe, Marsden, Tracy, Mclaughlan, Danielle, Mcmorrow, Liam, Pendlebury, Jessica, Perez, Jane, Poulaka, Maria, Proudfoot, Nicola, Slaughter, Melanie, Slevin, Kathryn, Thomas, Vicky, Walker, Danielle, Michael, Angiy, Collis, Matthew, Clark, Martyn, Coulding, Martina, Jude, Edward, Mccormick, Jacqueline, Mercer, Oliver, Potla, Darsh, Rehman, Hafiz, Savill, Heather, Turner, Victoria, Davey, Miriam, Golden, David, Seaman, Rebecca, Hunt, Jodie, Dearden, Joy, Dobson, Emma, Mulcahy, Michelle, Munt, Sheila, O’Connor, Grainne, Philbin, Jennifer, Rishton, Chloe, Tully, Redmond, Winnard, Sarah, Cagova, Lenka, Fofano, Adama, Garner, Lucie, Holcombe, Helen, Mepham, Sue, Mitchell, Alice Michael, Mwaura, Lucy, Praman, K., Vuylsteke, Alain, Zamikula, Julie, Bercades, Georgia, Brealey, David, Hass, Ingrid, Maccallum, Niall, Martir, Glady, Raith, Eamon, Reyes, Anna, Smyth, Deborah, Taylor, Abigail, Hughes, Rachel Anne, Thomas, Helen, Rees, Alun, Duskova, Michaela, Phipps, Janet, Brooks, Suzanne, Edwards, Michelle, Alexander, Peter, Allen, Schvearn, Bradley-Potts, Joanne, Brantwood, Craig, Egan, Jasmine, Felton, Timothy, Padden, Grace, Ward, Luke, Moss, Stuart, Glasgow, Susannah, Beesley, Kate, Board, Sarah, Kubisz-Pudelko, Agnieszka, Lewis, Alison, Perry, Je, Pippard, Lucy, Wood, Di, Buckley, Clare, Brown, Alison, Gregory, Jane, O’Connell, Susan, Smith, Tim, Belagodu, Zakaula, Fuller, Bridget, Gherman, Anca, Olufuwa, Olumide, Paramsothy, Remi, Stuart, Carmel, Oakley, Naomi, Kamundi, Charlotte, Tyl, David, Collins, Katy, Silva, Pedro, Taylor, June, King, Laura, Coates, Charlotte, Crowley, Maria, Wakefield, Phillipa, Beadle, Jane, Johnson, Laura, Sargeant, Janet, Anderson, Madeleine, Jardine, Catherine, Williams, Dewi, Parris, Victoria, Quaid, Sheena, Watson, Ekaterina, Melville, Julie, Naisbitt, Jay, Joseph, Rosane, Lazo, Maria, Walton, Olivia, Neal, Alan, Hill, Michaela, Kannan, Thogulava, Wild, Laura, Allan, Elizabeth, Darlington, Kate, Davies, Ffyon, Easton, Jack, Kumar, Sumit, Lean, Richard, Menzies, Daniel, Pugh, Richard, Qiu, Xinyi, Davies, Llino, Williams, Hannah, Scanlon, Jeremy, Davies, Gwyneth, Mackay, Callum, Lewis, Joannne, Rees, Stephanie, Coetzee, Samantha, Gales, Alistair, Raj, Meena, Sell, Craig, Langton, Helen, Watters, Malcolm, Novis, Catherine, Arbane, Gill, Bociek, Aneta, Campos, Sara, Grau, Neu, Jones, Tim Owen, Lim, Rosario, Marotti, Martina, Whitton, Christopher, Barron, Anthony, Collins, Ciara, Kaul, Sundeep, Passmore, Heather, Prendergast, Claire, Reed, Anna, Rogers, Paula, Shokkar, Rajvinder, Woodruff, Meriel, Middleton, Hayley, Polgar, Oliver, Nolan, Claire, Thwaites, Vicky, Mahay, Kanta, Sri-Chandana, Chunda, Scherewode, Joslan, Stephenson, Lorraine, Marsh, Sarah, Bancroft, Hollie, Bellamy, Mary, Carmody, Margaret, Daglish, Jacqueline, Moore, Faye, Rhodes, Joanne, Sangombe, Mirriam, Kadiri, Salma, Ayers, Amanda, Harrison, Wendy, North, Julie, Cavazza, Anna, Cockrell, Maeve, Corcoran, Eleanor, Depante, Maria, Finney, Clare, Jerome, Ellen, Mcphail, Mark, Nayak, Monalisa, Noble, Harriet, O’Reilly, Kevin, Pappa, Evita, Saha, Rohit, Saha, Sian, Smith, John, Knighton, Abigail, Gill, Mandy, Paul, Paul, Ratnam, Valli, Shelton, Sarah, Wynter, Inez, Baptista, David, Crowe, Rebecca, Fernandes, Rita, Herdman-Grant, Rosaleen, Joseph, Anna, Loveridge, Adam, Mckenley, India, Morino, Eriko, Naranjo, Andre, Simms, Richard, Sollesta, Kathryn, Swain, Andrew, Venkatesh, Harish, Khera, Jacyntha, Fox, Jonathan, Barber, Russell, Hewitt, Claire, Hilldrith, Annette, Jackson-Lawrence, Karen, Shepardson, Sarah, Wills, Maryanne, Butler, Susan, Tavares, Silvia, Cunningham, Amy, Hindale, Julia, Arif, Sarwat, George, Linsha, Twiss, Sophie, Wright, David, Holland, Maureen, Keenan, Natalie, Lyons, Marc, Wassall, Helen, Marsh, Chri, Mahenthran, Mervin, Carter, Emma, Kong, Thoma, Adanini, Oluronke, Bhatia, Nikhil, Msiska, Maine, Mew, Louise, Mwaura, Esther, Williams, Felicity, Wren, Lynn, Sutherland, Sara-Beth, Battle, Ceri, Brinkworth, Elaine, Harford, Rachel, Murphy, Carl, Newey, Luke, Rees, Tabitha, Williams, Marie, Arnold, Sophie, Hardy, John, Houlden, Henry, Moncur, Eleanor, Tariq, Ambreen, Tucci, Arianna, Convery, Karen, Fottrell-Gould, Deirdre, Hudig, Lisa, Keshet-Price, Jocelyn, Randell, Georgina, Stammers, Katie, Abdelrazik, Marwa, Bakthavatsalam, Dhanalakshmi, Elhassan, Munzir, Ganesan, Arunkumar, Haldeos, Anne, Moreno-Cuesta, Jeronimo, Purohit, Dharam, Vincent, Rachel, Xavier, Kugan, Rohit, Kumar, Alasdair, Frater, Saleem, Malik, David, Carter, Jenkins, Samuel, Lamond, Zoe, Wall, Alanna, Reynolds, Jessica, Campbell, Helen, Thompsom, Maria, Dodds, Steve, Duffy, Stacey, Butcher, Deborah, O’Sullivan, Susie, Butterworth-Cowin, Nicola, Deacon, Bethan, Hibbert, Meg, Pothecary, Carla, Tetla, Dariusz, Woodford, Christopher, Durga, Latha, Kennard-Holden, Gareth, de Gordoa, Laura Ortiz-Ruiz, Peasgood, Emily, Phillips, Claire, Skinner, Denise, Gaylard, Jane, Mullan, Dee, Newman, Julie, Davies, Ellie, Roche, Lisa, Sathe, Sonia, Brimfield, Lutece, Daly, Zoe, Pogson, David, Rose, Steve, Collins, Amy, Khaliq, Waqa, Gude, Estefania Treu, Allen, Louise, Beranova, Eva, Crisp, Nikki, Deery, Joanne, Hazelton, Tracy, Knight, Alicia, Price, Carly, Tilbey, Sorrell, Turki, Salah, Turney, Sharon, Giles, Julian, Booth, Simon, Bell, Gillian, English, Katy, Katary, Amro, Wilcox, Louise, Campbell, Rachael, Clarke, Noreen, Whiteside, Jonathan, Mascarenhas, Mairi, Donaldson, Avril, Matheson, Joanna, Barrett, Fiona, O’Hara, Marianne, O’Keefe, Laura, Bradley, Clare, Collier, Dawn, Walker, Rachel, Maynard, Victoria, Patel, Tahera, Smith, Matthew, Kazi, Aayesha, Hartley, Janice, Dykes, Joseph, Hijazi, Muhammad, Keith, Sarah, Khan, Meherunnisa, Ryan-Smith, Janet, Springle, Philippa, Thomas, Jacqueline, Truman, Nick, Saad, Samuel, Coleman, Dabheoc, Fine, Christopher, Matt, Roseanna, Gay, Bethan, Dalziel, Jack, Ali, Syamlan, Goodchild, Drew, Harling, Rhiannan, Bhatterjee, Ravi, Goddard, Wendy, Davison, Chloe, Duberly, Stephen, Hargreaves, Jeanette, Bolton, Rachel, Verlander, Mark, Williams, Alexandra, Blackman, Helen, Creagh-Brown, Ben, Donlon, Sinead, Michalak-Glinska, Natalia, Mtuwa, Sheila, Pristopan, Veronika, Salberg, Armorel, Smith, Eleanor, Stone, Sarah, Piercy, Charle, Verula, Jerik, Burda, Dorota, Montaser, Rugia, Harden, Lesley, Mayangao, Irving, Marriott, Cheryl, Bradley, Paul, Harris, Celia, Cooper, Joshua, Finch, Cheryl, Liderth, Sarah, Quinn, Alison, Waddington, Natalia, Fidler, Katy, Tagliavini, Emma, Donnelly, Kevin, Abel, Lynn, Brett, Michael, Digby, Brian, Gemmell, Lisa, Hornsby, Jame, Macgoey, Patrick, O’Neil, Pauline, Price, Richard, Rodden, Natalie, Rooney, Kevin, Sundaram, Radha, Thomson, Nicola, Flanagan, Rebecca, Hughes, Gareth, Latham, Scott, Mckenna, Emma, Anderson, Jennifer, Hull, Robert, Rhead, Kat, Branney, Debbie, Frankham, Jordan, Pitts, Sally, White, Nigel, Cristiano, Daniele, Dormand, Natalie, Farzad, Zohreh, Gummadi, Mahitha, Liyanage, Kamal, Patel, Brijesh V., Salmi, Sara, Sloane, Geraldine, Varghese, Mathew, Zborowski, Anelise C., Bean, Sarah, Burt, Karen, Spivey, Michael, Eastgate-Jackson, Christine, Filipe, Helder, Martin, Daniel, Maharajh, Amitaa, Garcia, Sara Mingo, De Neef, Mark, Lynch, Ceri, Howe, Gwenllian Sera, Singh, Jayaprakash, Turner, Keri, Ellis, Hannah, Stroud, Natalie, Cherian, Shiney, Cutler, Sean, Heron, Anne Emma, Roynon-Reed, Anna, Williams, Gemma, Richards, Owen, Cheema, Yusuf, Ahmad, Norfaizan, Barker, Joann, Bauchmuller, Kri, Bird, Sarah, Cawthron, Kay, Harrington, Kate, Jackson, Yvonne, Kibutu, Faith, Lenagh, Becky, Masuko, Shamiso, Raithatha, Ajay, Wiles, Matthew, Willson, Jayne, Newell, Helen, Lye, Alison, Nwafor, Lorenza, Jarman, Claire, Rowland-Jones, Sarah, Foote, David, Cole, Joby, Thompson, Roger, Watson, Jame, Hesseldon, Lisa, Macharia, Irene, Chetam, Luke, Smith, Jacqui, Ford, Amber, Anderson, Samantha, Birchall, Kathryn, Housley, Kay, Walker, Sara, Milner, Leanne, Hanratty, Helena, Trower, Helen, Phillips, Patrick, Oxspring, Simon, Donne, Ben, Bevan, Emily, Martin, Jane, Trodd, Dawn, Watson, Geoff, Brown, Caroline Wrey, Bunni, Lara, Jennings, Claire, Latif, Monica, Marshall, Rebecca, Subramanian, Gayathri, Bandla, Nageswar, Gellamucho, Minnie, Davies, Michelle, Thompson, Christopher, Trim, Fiona, Eapen, Beena, Ahmed, Cecilia, Baines, Balvinder, Clamp, Sarah, Colley, Julie, Haq, Risna, Hayes, Anne, Hulme, Jonathan, Hussain, Samia, Joseph, Sibet, Kumar, Rita, Maqsood, Zahira, Purewal, Manjit, Chandler, Ben, Elliott, Kerry, Mallinson, Janine, Turnbull, Alison, Dent, Kathy, Horsley, Elizabeth, Akhtar, Muhmmad Nauman, Pearson, Sandra, Potoczna, Dorota, Spencer, Sue, Blakemore, Hayley, Borislavova, Borislava, Faulkner, Beverley, Gendall, Emma, Goff, Elizabeth, Hayes, Kati, Thomas, Matt, Worner, Ruth, Smith, Kerry, Stephens, Deanna, Delgado, Carlos Castro, Dawson, Deborah, Ding, Lijun, Durrant, Georgia, Ezeobu, Obiageri, Farnell-Ward, Sarah, Harrison, Abiola, Kanu, Rebecca, Leaver, Susannah, Maccacari, Elena, Manna, Soumendu, Saluzzio, Romina Peperman, Queiroz, Joana, Samakomva, Tinashe, Sicat, Christine, Texeira, Joana, Da Gloria, Edna Fernande, Lisboa, Ana, Rawlins, John, Mathew, Jisha, Kinch, Ashley, Hurt, William Jame, Shah, Nirav, Clark, Victoria, Thanasi, Maria, Yun, Nikki, Patel, Kamal, Crickmore, Vikki, Debreceni, Gabor, Wilkins, Joy, Nicol, Liz, Burn, Iona, Hambrook, Geraldine, Manso, Katarina, Penn, Ruth, Shanmugasundaram, Pradeep, Tebbutt, Julie, Thornton, Danielle, Rostron, Anthony, Roy, Alistair, Woods, Lindsey, Cornell, Sarah, Wakinshaw, Fiona, Rogerson, Kimberley, Jarmain, Jordan, Anderson, Peter, Archer, Katie, Austin, Karen, Davis, Caroline, Durie, Alison, Kelsall, Olivia, Thrush, Jessica, Vigurs, Charlie, Wood, Hannah-Louise, Tranter, Helen, Harrison, Alison, Cowley, Nichola, Mcalindon, Michael, Digby, Stephen, Low, Emma, Morgan, Aled, Cother, Naiara, Rankin, Tobia, Clayton, Sarah, Mccurdy, Alex, Allibone, Suzanne, Mary-Genetu, Roman, Patel, Amit, Mac, Ainhi, Murphy, Anthony, Mahjoob, Parisa, Nazari, Roonak, Worsley, Lucy, Fagan, Andrew, Mohamed Ali, Inthakab Ali, Beaumont, Karen, Blunt, Mark, Coton, Zoe, Curgenven, Hollie, Elsaadany, Mohamed, Fernandes, Kay, Ally, Sameena Mohamed, Rangarajan, Harini, Sarathy, Varun, Selvanayagam, Sivarupan, Vedage, Dave, White, Matthew, Fernandez-Roman, Jaime, Hamilton, David O., Johnson, Emily, Johnston, Brian, Martinez, Maria Lopez, Mulla, Suleman, Shaw, David, Waite, Alicia A. C., Waugh, Victoria, Welters, Ingeborg D., Williams, Karen, Bemand, Thoma, Black, Ethel, Rosa, Arnold Dela, Howle, Ryan, Jhanji, Shaman, Baikady, Ravishankar Rao, Tatham, Kate Colette, Thomas, Benjamin, Halkes, Matthew, Mercer, Pauline, Thornton, Lorraine, West, Joe, Baird, Tracy, Ruddy, Jim, Reece-Anthony, Rosie, Birt, Mark, Cowton, Amanda, Kay, Andrea, Kent, Melanie, Potts, Kathryn, Wilkinson, Ami, Naylor, Suzanne, Brown, Ellen, Clark, Michele, Purvis, Sarah, Cole, Jade, Davies, Rhy, Duffin, Donna, Hill, Helen, Player, Ben, Thomas, Emma, Williams, Angharad, Beith, Claire Marie, Black, Karen, Clements, Suzanne, Morrison, Alan, Strachan, Dominic, Taylor, Margaret, Clarkson, Michelle, D’Sylva, Stuart, Norman, Kathryn, Coventry, Tina, Fowler, Susan, Mcgregor, Amanda, Brady, Ailbhe, Chan, Rebekah, Mcivor, Shane, Prady, Helena, Whittle, Helen, Mathew, Bijoy, Clapham, Melanie, Harper, Rosemary, Poultney, Una, Rice, Polly, Mutch, Rachel, Baird, Yolanda, Butler, Aaron, Chadbourn, Indra, Folkes, Linda, Fox, Heather, Gardner, Amy, Gomez, Raquel, Hobden, Gillian, King, Kirsten, Margarson, Michael, Martindale, Tim, Meadows, Emma, Raynard, Dana, Thirlwall, Yvette, Helm, David, Margalef, Jordi, Greer, Sandra, Shuker, Karen, Smuts, Sara, Duffield, Joseph, Smith, Oliver, Mallon, Lewi, Claire, Watkin, Birkinshaw, Isobel, Carter, Joseph, Howard, Kate, Ingham, Joanne, Joy, Rosie, Pearson, Harriet, Roche, Samantha, Scott, Zoe, Knights, Ellen, Price, Alicia, Thomas, Alice, Thorpe, Chri, Abraheem, Azmerelda, Bamford, Peter, Cawley, Kathryn, Dunmore, Charlie, Faulkner, Maria, Girach, Rumanah, Jeffrey, Helen, Jones, Rhianna, London, Emily, Nagra, Imrun, Nasir, Farah, Sainsbury, Hannah, Smedley, Clare, Khade, Reena, Sundar, Ashok, Tsinaslanidis, George, Behan, Teresa, Burnett, Caroline, Hatton, Jonathan, Heeney, Elaine, Mitra, Atideb, Newton, Maria, Pollard, Rachel, Stead, Rachael, Birch, Jenny, Bough, Laura, Goodsell, Josie, Tutton, Rebecca, Williams, Patricia, Williams, Sarah, Winter-Goodwin, Barbara, Auld, Fiona, Donnachie, Joanne, Edmond, Ian, Prentice, Lynn, Runciman, Nikole, Salutous, Dario, Symon, Lesley, Todd, Anne, Turner, Patricia, Short, Abigail, Sweeney, Laura, Murdoch, Euan, Senaratne, Dhaneesha, Burns, Karen, Higham, Andrew, Anderson, Taya, Hawcutt, Dan, O’Malley, Laura, Rad, Laura, Rogers, Naomi, Saunderson, Paula, Allison, Kathryn Sian, Afolabi, Deborah, Whitbread, Jennifer, Jones, Dawn, Dore, Rachael, Lankester, Liana, Nikitas, Nikita, Wells, Colin, Stowe, Bethan, Spencer, Kayleigh, Cathcart, Susanne, Duffy, Katharine, Puxty, Alex, Puxty, Kathryn, Turner, Lynne, Ireland, Jane, Semple, Gary, Barry, Peter, Hilltout, Paula, Evitts, Jayne, Tyler, Amanda, Waldron, Joanne, Irvine, Val, Shelley, Benjamin, Akinkugbe, Olugbenga, Bamford, Alasdair, Beech, Emily, Belfield, Holly, Bell, Michael, Davies, Charlene, Jones, Gareth A. L., Mchugh, Tara, Meghari, Hamza, O’Neill, Lauran, Peters, Mark J., Ray, Samiran, Tomas, Ana Luisa, Gorman, Claire, Gupta, Abhinav, Timlick, Elizabeth, Brady, Rebecca, Bonner, Stephen, Hugill, Keith, Jones, Jessica, Liggett, Steven, Bashyal, Archana, Davidson, Neil, Hutton, Paula, Mckechnie, Stuart, Wilson, Jean, Flint, Neil, Rekha, Patel, Hales, Dawn, Cruz, Carina, Gopal, Shameer, Harris, Nichola, Lake, Victoria, Metherell, Stella, Radford, Elizabeth, Clement, Ian, Patel, Bijal, Gulati, A., Hays, Carole, Webster, K., Hudson, Anne, Webster, Andrea, Stephenson, Elaine, Mccormack, Louise, Slater, Victoria, Nixon, Rachel, Hanson, Helen, Fearby, Maggie, Kelly, Sinead, Bridgett, Victoria, Robinson, Philip, Almaden-Boyle, Christine, Austin, Pauline, Cabrelli, Louise, Cole, Stephen, Casey, Matt, Chapman, Susan, Whyte, Clare, Brayne, Adam, Fisher, Emma, Hunt, Jane, Jackson, Peter, Kaye, Duncan, Love, Nichola, Parkin, Juliet, Tuckey, Victoria, van Koutrik, Lynne, Carter, Sasha, Andrew, Benedict, Findlay, Louise, Adams, Katie, Bruce, Michelle, Connolly, Karen, Duncan, Tracy, T. -Michael, Helen, Lindergard, Gabriella, Hey, Samuel, Fox, Claire, Alfonso, Jordan, Durrans, Laura Jayne, Guerin, Jacinta, Hruska, Martin, Eltayeb, Ayaa, Lamb, Thoma, Hodgkiss, Tracey, Cooper, Lisa, Rothwell, Joanne, Dennis, Catherine, Mcgregor, Alastair, Srikaran, Sinduya, Sukha, Anisha, Davies, Kim, O’Brien, Linda, Omar, Zohra, Perkins, Emma, Lewis, Tracy, Sutherland, Isobel, Brooke, Hollie, Buckley, Sarah, Suarez, Jose Cebrian, Charlesworth, Ruth, Hansson, Karen, Norris, John, Poole, Alice, Rose, Alastair, Sandhu, Rajdeep, Sloan, Brendan, Smithson, Elizabeth, Thirumaran, Muthu, Wagstaff, Veronica, Metcalfe, Alexandra, Camsooksai, Julie, Humphrey, Charlotte, Jenkins, Sarah, Wadams, Beverley, Death, Yasmin, Adams, Colene, Agasou, Anita, Arden, Tracie, Bowes, Amy, Boyle, Pauline, Beekes, Mandy, Button, Heather, Capps, Nigel, Carnahan, Mandy, Carter, Anne, Childs, Danielle, Donaldson, Denise, Hard, Kelly, Hurford, Fran, Hussain, Yasmin, Javaid, Ayesha, Jones, Jame, Jose, Sanal, Leigh, Michael, Martin, Terry, Millward, Helen, Motherwell, Nichola, Rikunenko, Rachel, Stickley, Jo, Summers, Julie, Ting, Louise, Tivenan, Helen, Tonks, Louise, Wilcox, Rebecca, Bokhari, Maria, Lucas, Rachael, Mccormick, Wendy, Ritzema, Jenny, Sanderson, Amanda, Wild, Helen, Baxter, Nicola, Henderson, Steven, Kennedy-Hay, Sophie, Mcparland, Christopher, Rooney, Laura, Sim, Malcolm, Mccreath, Gordan, Brunton, Mark, Caterson, Je, Coles, Holly, Frise, Matthew, Rai, Sabi Gurung, Keating, Liza, Tilney, Emma, Bartley, Shauna, Bhuie, Parminder, Downes, Charlotte, Holding, Kathleen, Riches, Katie, Hilton, Mary, Hayman, Mel, Subramanian, Deepak, Daniel, Priya, Zitter, Letizia, Benyon, Sarah, Marriott, Suzie, Park, Linda, Keenan, Samantha, Gordon, Elizabeth, Quinn, Helen, Baines, Kizzy, Andrew, Gillian, Barclay, Lucy, Callaghan, Marie, Clark, Sarah, Hope, Dave, Marshall, Lucy, Mcculloch, Corrienne, Briton, Kate, Singleton, Jo, Birch, Sophie, Simpson, Kerry, Craig, Jayne, Demetriou, Carrie, Eckbad, Charlotte, Hierons, Sarah, Howie, Lucy, Mitchard, Sarah, Ramos, Lidia, Serrano-Ruiz, Alfredo, White, Katie, Kelly, Fiona, Amin, Vishal, Anastasescu, Elena, Anumakonda, Vikram, Karthik, Komala, Kausar, Rizwana, Reid, Karen, Smith, Jacqueline, Imeson-Wood, Janet, Bellini, Arianna, Bryant, Jade, Mayer, Anton, Pickard, Amy, Roe, Nichola, Sowter, Jason, Howlett, Alex, Criste, Kristine, Cusack, Rebecca, Golder, Kim, Golding, Hannah, Jones, Oliver, Leggett, Samantha, Male, Michelle, Marani, Martyna, Prager, Kirsty, Williams, Toran, Roberts, Belinda, Salmon, Karen, Gondo, Prisca, Hadebe, B., Kayani, Abdul, Masunda, Bridgett, Ahmed, Ashar, Morris, Anna, Jakkula, Sriniva, Long, Kate, Whiteley, Simon, Wilby, Elizabeth, Ogg, Bethan, Moultrie, Sam, Odam, M., Bewley, Jeremy, Garland, Zoe, Grimmer, Lisa, Gumbrill, Bethany, Johnson, Rebekah, Sweet, Katie, Webster, Denise, Efford, Georgia, Bennett, Sara, Goodwin, Emma, Jackson, Matthew, Kent, Alissa, Tibke, Clare, Woodyatt, Wiesia, Zaki, Ahmed, Daniel, Amelia, Finn, Joanne, Saha, Rajnish, Bremmer, Pamela, Allan, J., Geary, T., Houston, Gordon, Meikle, A., O’Brien, P., Bell, Dina, Boyle, Rosalind, Douglas, Katie, Glass, Lynn, Lee, Emma, Lennon, Liz, Rattray, Austin, Charnock, Rob, Mcfarland, Denise, Cosgrove, Denise, Attwood, Ben, Parsons, Penny, Carmody, Siobhain, Oblak, Metod, Popescu, Monica, Thankachen, Mini, Baruah, Rosie, Morris, Sheila, Ferguson, Susie, Shepherd, Amy, Altabaibeh, Abdelhakim, Alvaro, Ana, Gilbert, Kayleigh, Ma, Louise, Mostoles, Loreta, Parmar, Chetan, Simpson, Kathryn, Jetha, Champa, Booker, Lauren, Pratley, Anezka, Cosier, Tracey, Millen, Gemma, Schumacher, Natasha, Weston, Heather, Rand, Jame, Alex, Beatrice, Bach, Benjamin, Barclay, Wendy S., Bogaert, Debby, Chand, Meera, Cooke, Graham S., Docherty, Annemarie B., Dunning, Jake, da Silva Filipe, Ana, Fletcher, Tom, Green, Christoper A., Harrison, Ewen M., Hiscox, Julian A., Ijaz, Samreen, Khoo, Saye, Lim, Wei Shen, Mentzer, Alexander J., Merson, Laura, Noursadeghi, Mahdad, Moore, Shona C., Palmarini, Massimo, Paxton, William A., Pollakis, Georgio, Price, Nichola, Rambaut, Andrew, Robertson, David L., Sancho-Shimizu, Vanessa, Scott, Janet T., de Silva, Thushan, Sigfrid, Louise, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Tedder, Richard S., Thomson, Emma C., Roger Thompson, A. A., Thwaites, Ryan S., Turtle, Lance C. W., Gupta, Rishi K., Palmieri, Carlo, Swann, Olivia V., Zambon, Maria, Dumas, Marc-Emmanuel, Griffin, Julian L., Takats, Zoltan, Chechi, Kanta, Andrikopoulos, Petro, Osagie, Anthonia, Olanipekun, Michael, Liggi, Sonia, Lewis, Matthew R., Correia, Gonçalo dos Santo, Sands, Caroline J., Takis, Panteleimon, Maslen, Lynn, Greenhalf, William, Shaw, Victoria, Mcdonald, Sarah E., Keating, Seán, Ahmed, Katie A., Armstrong, Jane A., Ashworth, Milton, Asiimwe, Innocent G., Bakshi, Siddharth, Barlow, Samantha L., Booth, Laura, Brennan, Benjamin, Bullock, Katie, Catterall, Benjamin W. A., Clark, Jordan J., Clarke, Emily A., Cooper, Louise, Cox, Helen, Davis, Christopher, Dincarslan, Oslem, Dunn, Chri, Dyer, Philip, Elliott, Angela, Evans, Anthony, Finch, Lorna, Fisher, Lewis W. S., Foster, Terry, Garcia-Dorival, Isabel, Gunning, Philip, Hartley, Catherine, Jensen, Rebecca L., Jones, Christopher B., Jones, Trevor R., Khandaker, Shadia, King, Katharine, Kiy, Robyn T., Koukorava, Chrysa, Lake, Annette, Lant, Suzannah, Latawiec, Diane, Lavelle-Langham, Lara, Lefteri, Daniella, Lett, Lauren, Livoti, Lucia A., Mancini, Maria, Mcdonald, Sarah, Mcevoy, Laurence, Mclauchlan, John, Metelmann, Soeren, Miah, Nahida S., Middleton, Joanna, Mitchell, Joyce, Murphy, Ellen G., Penrice-Randal, Rebekah, Pilgrim, Jack, Prince, Tessa, Reynolds, Will, Ridley, P. Matthew, Sales, Debby, Shaw, Victoria E., Shears, Rebecca K., Small, Benjamin, Subramaniam, Krishanthi S., Szemiel, Agnieska, Taggart, Aislynn, Tanianis-Hughes, Jolanta, Thomas, Jordan, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Zhang, J. Eunice, Flaherty, Lisa, Maziere, Nicole, Cass, Emily, Carracedo, Alejandra Doce, Carlucci, Nicola, Holmes, Anthony, Massey, Hannah, Murphy, Lee, Wrobel, Nicola, Mccafferty, Sarah, Morrice, Kirstie, Maclean, Alan, Armstrong, Ruth, Boz, Ceilia, Brown, Adam, Coutts, Audrey, Cullum, Louise, Day, Nicky, Donnelly, Lorna, Duncan, Esther, Fawkes, Angie, Finernan, Paul, Gilchrist, Tammy, Golightly, Ailsa, Hafezi, Katarzyna, Law, Dawn, Law, Rachel, Law, Sarah, Macgillivray, Louise, Mal, Hanning, Mcmaster, Ellie, Meikle, Jen, Oosthuyzen, Wilna, Paterson, Trevor, Stenhouse, Andrew, Swets, Maaike, Szoor-McElhinney, Helen, Taneski, Filip, Wackett, Tony, Ward, Mairi, Weaver, Jane, Coyle, Judy, Gallagher, Bernadette, Lidstone-Scott, Rebecca, Hamilton, Debbie, Schon, Katherine, Furlong, Anita, Biggs, Heather, Griffiths, Fiona, Andrews, Eleanor, Brickell, Kathy, Smyth, Michelle, Murphy, Lorna, Carson, Gail, Hardwick, Hayley, Donohue, Chloe, Pérez-Tur, Jordi [0000-0002-9111-1712], Martín, Javier [0000-0002-2202-0622], Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Massachusetts General Hospital [Boston], A list of authors and their affiliations appears in the Supplementary Information, Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, ANR-20-CO11-0001,AABIFNCOV,Bases génétiques et immunologiques des auto-anticorps contre les interférons de type I prédisposant aux formes sévères de COVID-19.(2020), ANR-20-COVI-0003,GENCOVID,Identification des défauts monogéniques de l'immunité responsables des formes sévères de COVID-19 chez les patients précédemment en bonne santé(2020), ANR-21-COVR-0039,GenMIS-C,Recherche des Déficits immunitaires innées monogéniques prédisposant au syndrome inflammatoire multisystémique chez l'enfant.(2021), UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Niemi, M, Karjalainen, J, Liao, R, Neale, B, Daly, M, Ganna, A, Pathak, G, Andrews, S, Kanai, M, Veerapen, K, Fernandez-Cadenas, I, Schulte, E, Striano, P, Marttila, M, Minica, C, Marouli, E, Karim, M, Wendt, F, Savage, J, Sloofman, L, Butler-Laporte, G, Kim, H, Kanoni, S, Okada, Y, Byun, J, Han, Y, Uddin, M, Smith, G, Willer, C, Buxbaum, J, Mehtonen, J, Finucane, H, Cordioli, M, Martin, A, Zhou, W, Pasaniuc, B, Julienne, H, Aschard, H, Shi, H, Yengo, L, Polimanti, R, Ghoussaini, M, Schwartzentruber, J, Dunham, I, Chwialkowska, K, Francescatto, M, Trankiem, A, Balaconis, M, Davis, L, Lee, S, Priest, J, Renieri, A, Sankaran, V, van Heel, D, Deelen, P, Richards, J, Nakanishi, T, Biesecker, L, Kerchberger, V, Baillie, J, Mari, F, Bernasconi, A, Baillie, S, Canakoglu, A, Wolford, B, Faucon, A, Dutta, A, Schurmann, C, Harry, E, Birney, E, Nguyen, H, Nasir, J, Kaunisto, M, Solomonson, M, Dueker, N, Vadgama, N, Limou, S, Rahmouni, S, Mbarek, H, Darwish, D, Albertos, R, Pérez-Tur, J, Li, R, Folkersen, L, Moltke, I, Koelling, N, Teumer, A, Kousathanas, A, Utrilla, A, Verdugo, R, Zárate, R, Medina-Gómez, C, Gómez-Cabrero, D, Carnero-Montoro, E, Cadilla, C, Moreno-Estrada, A, Garmendia, A, Moya, L, Sedaghati-Khayat, B, Boua, P, Favé, M, Francioli, L, Lemaçon, A, Migeotte, I, Patel, S, Varnai, R, Szentpeteri, J, Sipeky, C, Colombo, F, von Hohenstaufen, K, Lio, P, Vallerga, C, Wang, Q, Tanigawa, Y, Im, H, Han, C, Song, H, Lim, J, Lee, Y, Kim, S, Im, S, Atanasovska, B, Ahmad, H, Boer, C, Jansen, P, Franke, L, Kaja, E, Pasko, D, Kennis-Szilagyi, I, Kornilov, S, Prijatelj, V, Prokić, I, Sivanadhan, I, Perumal, S, Esmaeeli, S, Pearson, N, Auton, A, Shelton, J, Shastri, A, Filshtein-Sonmez, T, Coker, D, Symons, A, Esparza-Gordillo, J, Aslibekyan, S, O’Connell, J, Ye, C, Weldon, C, Perera, M, O’Leary, K, Tuck, M, O’Brien, T, Meltzer, D, O’Donnell, P, Nutescu, E, Yang, G, Alarcon, C, Herrmann, S, Mazurek, S, Banagan, J, Hamidi, Z, Barbour, A, Raffat, N, Moreno, D, Friedman, P, Ferwerda, B, van de Beek, D, Brouwer, M, Vlaar, A, Wiersinga, W, Posthuma, D, Tissink, E, Koos Zwinderman, A, Uffelmann, E, van Agtmael, M, Algera, A, van Baarle, F, Bax, D, Beudel, M, Jan Bogaard, H, Bomers, M, Bonta, P, Bos, L, Botta, M, de Brabander, J, de Bree, G, de Bruin, S, Bugiani, M, Bulle, E, Chouchane, O, Cloherty, A, Dongelmans, D, Elbers, P, Fleuren, L, Geerlings, S, Geerts, B, Geijtenbeek, T, Girbes, A, Goorhuis, B, Grobusch, M, Hafkamp, F, Hagens, L, Hamann, J, Harris, V, Hemke, R, Hermans, S, Heunks, L, Hollmann, M, Horn, J, Hovius, J, de Jong, M, Koning, R, van Mourik, N, Nellen, J, Nossent, E, Paulus, F, Peters, E, van der Poll, T, Preckel, B, Prins, J, Raasveld, J, Reijnders, T, Schinkel, M, Schultz, M, Schuurman, A, Sigaloff, K, Smit, M, Stijnis, C, Stilma, W, Teunissen, C, Thoral, P, Tsonas, A, van der Valk, M, Veelo, D, de Vries, H, van Vugt, M, Wouters, D, Minnaar, R, Kromhout, A, van Uffelen, K, Wolterman, R, Roberts, G, Park, D, Ball, C, Coignet, M, Mccurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, E, Rand, K, Girshick, A, Guturu, H, Baltzell, A, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Bouysran, Y, Busson, A, Peyrassol, X, Wilkin, F, Pichon, B, Smits, G, Vandernoot, I, Goffard, J, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Jadot, L, Azarzar, S, Dellot, P, Gofflot, S, Claassen, S, Bertrand, A, Parzibut, G, Clarinval, M, Moermans, C, Malaise, O, El Kandoussi, K, Thonon, R, Huynen, P, Mesdagh, A, Melo, S, Jacques, N, Di Valentin, E, Giroule, F, Collignon, A, Radermecker, C, Lebrun, M, Perée, H, Latour, S, Barada, O, Sanchez, J, Josse, C, Boujemla, B, Meunier, M, Mariavelle, E, Anania, S, Gazon, H, Juszczak, D, Fadeur, M, Camby, S, Meuris, C, Thys, M, Jacques, J, Henket, M, Léonard, P, Frippiat, F, Giot, J, Sauvage, A, Von Frenckell, C, Mni, M, Wéry, M, Staderoli, A, Belhaj, Y, Lambermont, B, Morrison, D, Mooser, V, Forgetta, V, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, D, Lathrop, G, Adra, D, Cox, N, Below, J, Sealock, J, Shuey, M, Polikowsky, H, Petty, L, Shaw, D, Chen, H, Zhu, W, Ludwig, K, Schröder, J, Maj, C, Rolker, S, Nöthen, M, Fazaal, J, Keitel, V, Jensen, B, Feldt, T, Kurth, I, Marx, N, Dreher, M, Pink, I, Cornberg, M, Illig, T, Lehmann, C, Schommers, P, Augustin, M, Rybniker, J, Knopp, L, Eggermann, T, Volland, S, Altmüller, J, Berger, M, Brenner, T, Hinney, A, Witzke, O, Bals, R, Herr, C, Ludwig, N, Walter, J, Fuchsberger, C, Pattaro, C, De Grandi, A, Pramstaller, P, Emmert, D, Melotti, R, Foco, L, Mascalzoni, D, Gögele, M, Domingues, F, Hicks, A, Gignoux, C, Wicks, S, Crooks, K, Barnes, K, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Goldstein, D, Kiryluk, K, Sengupta, S, Chung, W, Reilly, M, Khan, A, Wang, C, Povysil, G, Bhardwaj, N, Gharavi, A, Ionita-Laza, I, Shang, N, O’Byrne, S, Nandakumar, R, Menon, A, So, Y, Hod, E, Pendrick, D, Park, S, Kang, C, Lee, H, Song, K, Jae Yoon, K, Paik, N, Seok, W, Yoon, H, Joo, E, Chang, Y, Ryu, S, Park, W, Su Park, J, Un Park, K, Ham, S, Jung, J, Kim, E, Ellinghaus, D, Degenhardt, F, Cáceres, M, Juzenas, S, Lenz, T, Albillos, A, Julià, A, Heidecker, B, Garcia, F, Kurth, F, Tran, F, Hanses, F, Zoller, H, Holter, J, Fernández, J, Sander, L, Rosenstiel, P, Koehler, P, de Cid, R, Asselta, R, Schreiber, S, Hehr, U, Prati, D, Baselli, G, Valenti, L, Bujanda, L, Banales, J, Duga, S, D’Amato, M, Romero-Gómez, M, Buti, M, Invernizzi, P, Franke, A, Hov, J, Karlsen, T, Folseraas, T, Maya-Miles, D, Teles, A, Azuure, C, Wacker, E, Uellendahl-Werth, F, Elabd, H, Arora, J, Lerga-Jaso, J, Wienbrandt, L, Rühlemann, M, Wendorff, M, Vadla, M, Lenning, O, Özer, O, Myhre, R, Raychaudhuri, S, Tanck, A, Gassner, C, Hemmrich-Stanisak, G, Kässens, J, Figuera Basso, M, Schulzky, M, Wittig, M, Braun, N, Wesse, T, Albrecht, W, Yi, X, Ortiz, A, Chercoles, A, Ruiz, A, Mantovani, A, Holten, A, Mayer, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Braun, A, Barreira, A, Lleo, A, Kildal, A, Glück, A, Nolla, A, Latiano, A, Dyrhol-Riise, A, Muscatello, A, Voza, A, Rando-Segura, A, Solier, A, Karina, B, Cortes, B, Mateos, B, Nafria-Jimenez, B, Schaefer, B, Bellinghausen, C, Ferrando, C, Quereda, C, Skurk, C, Thibeault, C, Spinner, C, Lange, C, Hu, C, Cappadona, C, Bianco, C, Sancho, C, Lihaug Hoff, D, Galimberti, D, Jiménez, D, Pestaña, D, Toapanta, D, Azzolini, E, Scarpini, E, Helbig, E, Urrechaga, E, Paraboschi, E, Pontali, E, Reverter, E, Navas, E, Arana, E, Sánchez, F, Ceriotti, F, Malvestiti, F, Mesonero, F, Pezzoli, G, Lamorte, G, Neb, H, My, I, Hernández, I, de Rojas, I, Galván-Femenia, I, Heyckendorf, J, Badia, J, Schneider, J, Goikoetxea, J, Kraft, J, Müller, K, Gaede, K, Garcia-Etxebarria, K, Tonby, K, Heggelund, L, Izquierdo-Sanchez, L, Sumoy, L, Lippert, L, Terranova, L, Garbarino, L, Téllez, L, Roade, L, Ostadreza, M, Intxausti, M, Kogevinas, M, Gutiérrez-Stampa, M, Vehreschild, M, Marquié, M, Castoldi, M, Cecconi, M, Boada, M, Seilmaier, M, Mazzocco, M, Rodríguez-Gandía, M, Ayo, N, Blay, N, Martínez, N, Cornely, O, Palmieri, O, Tentorio, P, Rodrigues, P, España, P, Hoffmann, P, Bacher, P, Suwalski, P, de Pablo, R, Nieto, R, Badalamenti, S, Ciesek, S, Bombace, S, Wilfling, S, Brunak, S, Heilmann-Heimbach, S, Ripke, S, Bahmer, T, Landmesser, U, Protzer, U, Rimoldi, V, Skogen, V, Andrade, V, Moreno, V, Poller, W, Farre, X, Wang, X, Khodamoradi, Y, Karadeniz, Z, de Salazar, A, Palom, A, Garcia-Fernandez, A, Blanco-Grau, A, Zanella, A, Bandera, A, Nebel, A, Biondi, A, Caballero-Garralda, A, Gori, A, Lind, A, Fracanzani, A, Peschuck, A, Pesenti, A, de la Horra, C, Milani, C, Paccapelo, C, Angelini, C, Cea, C, Muñiz-Diaz, E, Sandoval, E, Calderón, E, Solligård, E, Aziz, F, Martinelli-Boneschi, F, Peyvandi, F, Blasi, F, Medrano, F, Rodriguez-Frias, F, Müller, F, Grasselli, G, Costantino, G, Cardamone, G, Foti, G, Matullo, G, Kurihara, H, Afset, J, Damås, J, Ampuero, J, Martín, J, Erdmann, J, Bergan, J, Goerg, S, Ferrusquía-Acosta, J, Quero, J, Delgado, J, Guerrero, J, Risnes, K, Bettini, L, Moreira, L, Gustad, L, Santoro, L, Scudeller, L, Riveiro-Barciela, M, Schaefer, M, Carrabba, M, Valsecchi, M, Hernandez-Tejero, M, Acosta-Herrera, M, D’Angiò, M, Baldini, M, Cazzaniga, M, Ciccarelli, M, Bocciolone, M, Miozzo, M, Chueca, N, Montano, N, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Castro, P, Ferrer, R, Gualtierotti, R, Gallego-Durán, R, Morilla, R, Haider, S, Marsal, S, Aneli, S, Pelusi, S, Bosari, S, Aliberti, S, Dudman, S, Zheng, T, Pumarola, T, Cejudo, T, Monzani, V, Friaza, V, Peter, W, Dopazo, X, May, S, Grimsrud, M, Gudbjartsson, D, Stefansson, K, Sulem, P, Sveinbjornsson, G, Melsted, P, Norddahl, G, Swerford Moore, K, Thorsteinsdottir, U, Holm, H, Alarcón-Riquelme, M, Bernardo, D, Martínez-Bueno, M, Rello, S, Magi, R, Milani, L, Metspalu, A, Laisk, T, Läll, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Palotie, A, Rivolta, C, Bochud, P, Bibert, S, Boillat, N, Nussle, S, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Friolet, R, Vollenweider, P, Pagani, J, Oddo, M, zu Bentrup, F, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, R, Lannepoudenx, Y, Portopena, L, Desgranges, F, Filippidis, P, Guéry, B, Haefliger, D, Kampouri, E, Manuel, O, Munting, A, Papadimitriou-Olivgeris, M, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hügli, O, Meuwly, J, Pantet, O, Bochud, M, D’Acremont, V, Younes, S, Cerny, A, O’Mahony, L, von Mering, C, Frischknecht, M, Kleger, G, Filipovic, M, Kahlert, C, Wozniak, H, Negro, T, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, Carreras, A, Galván-Femenía, I, Farré, X, Cortés, B, Mercader, J, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castaño-Vinyals, G, Dobaño, C, Gori, M, Mondelli, M, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, M, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, G, Spagnesi, M, Canaccini, A, Ognibene, A, D’Arminio Monforte, A, Girardis, M, Antinori, A, Francisci, D, Schiaroli, E, Scotton, P, Panese, S, Scaggiante, R, Monica, M, Capasso, M, Fiorentino, G, Castori, M, Aucella, F, Di Biagio, A, Masucci, L, Valente, S, Mandalà, M, Zucchi, P, Giannattasio, F, Coviello, D, Mussini, C, Bosio, G, Tavecchia, L, Crotti, L, Rizzi, M, La Rovere, M, Sarzi-Braga, S, Bussotti, M, Ravaglia, S, Artuso, R, Perrella, A, Romani, D, Bergomi, P, Catena, E, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Di Pietro, M, Sabrina, R, Luchi, S, Barbieri, C, Acquilini, D, Andreucci, E, Paciosi, F, Segala, F, Tiseo, G, Falcone, M, Lista, M, Poscente, M, De Vivo, O, Petrocelli, P, Guarnaccia, A, Baroni, S, Perticaroli, V, Furini, S, Dei, S, Benetti, E, Picchiotti, N, Sanarico, M, Ceri, S, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Bergomi, M, Zguro, K, Capitani, K, Tanfoni, M, Fallerini, C, Daga, S, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, M, Lo Rizzo, C, Pinto, A, Beligni, G, Tommasi, A, Di Sarno, L, Palmieri, M, Carriero, M, Alaverdian, D, Iuso, N, Inchingolo, G, Busani, S, Bruno, R, Vecchia, M, Belli, M, Mantovani, S, Ludovisi, S, Quiros-Roldan, E, Antoni, M, Zanella, I, Siano, M, Emiliozzi, A, Fabbiani, M, Rossetti, B, Zanelli, G, Bergantini, L, D’Alessandro, M, Cameli, P, Bennet, D, Anedda, F, Marcantonio, S, Scolletta, S, Guerrini, S, Conticini, E, Frediani, B, Spertilli, C, Donati, A, Guidelli, L, Corridi, M, Croci, L, Piacentini, P, Desanctis, E, Cappelli, S, Verzuri, A, Anemoli, V, Pancrazi, A, Lorubbio, M, Merlini, E, Miraglia, F, Venturelli, S, Cossarizza, A, Vergori, A, Gabrieli, A, Riva, A, Andretta, F, Gatti, F, Parisi, S, Baratti, S, Piscopo, C, Russo, R, Andolfo, I, Iolascon, A, Carella, M, Merla, G, Squeo, G, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Sanguinetti, M, Giorli, A, Salerni, L, Parravicini, P, Menatti, E, Trotta, T, Coiro, G, Lena, F, Martinelli, E, Mancarella, S, Gabbi, C, Maggiolo, F, Ripamonti, D, Bachetti, T, Suardi, C, Parati, G, Bottà, G, Di Domenico, P, Rancan, I, Bianchi, F, Colombo, R, Hunt, K, Trembath, R, Huang, Q, Martin, H, Mason, D, Trivedi, B, Wright, J, Finer, S, Griffiths, C, Akhtar, S, Anwar, M, Arciero, E, Ashraf, S, Breen, G, Chung, R, Curtis, C, Chowdhury, M, Colligan, G, Deloukas, P, Durham, C, Hurles, M, Hussain, S, Islam, K, Lavery, C, Lerner, R, Macarthur, D, Maclaughlin, B, Miah, S, Newman, B, Safa, N, Tahmasebi, F, Smith, A, Boughton, A, Li, K, Lefaive, J, Annis, A, Jannes, C, Krieger, J, Pereira, A, Velho, M, Marques, E, Lima, I, Tada, M, Valino, K, Mccarthy, M, Rosenberger, C, Lee, J, Chang, D, Hammer, C, Hunkapiller, J, Mahajan, A, Pendergrass, S, Sucheston-Campbell, L, Yaspan, B, Shin, E, Jang, H, Kym, S, Kim, Y, Jeong, H, Kwon, K, Kim, J, Jang, Y, Choe, K, Kang, Y, Jee, S, Jung, K, Parikh, V, Ashley, E, Wheeler, M, Rivas, M, Bustamante, C, Pinksy, B, Febbo, P, Farh, K, Schroth, G, Desouza, F, Dalton, K, Christle, J, Deboever, C, Szalma, S, Rubinacci, S, Delaneau, O, Gorzynski, J, de Jong, H, Sutton, S, Youlton, N, Joshi, R, Jimenez-Morales, D, Hughes, C, Amar, D, Ioannidis, A, Hershman, S, Kirillova, A, Seo, K, Huang, Y, Shoura, M, Hammond, N, Watson, N, Raja, A, Huang, C, Sahoo, M, Wang, H, Zhen, J, Rakitko, A, Ilinsky, V, Yermakovich, D, Popov, I, Chernitsov, A, Kovalenko, E, Krasnenko, A, Plotnikov, N, Stetsenko, I, Kim, A, Cirulli, E, Schiabor Barrett, K, Bolze, A, White, S, Washington, N, Lu, J, Riffle, S, Tanudjaja, F, Ramirez, J, Leonetti, N, Neveux, I, Dabe, S, Grzymski, J, Esteban Miñano, J, Aguirre, L, López-Collazo, E, de la Mata Pazos, M, Cerrato, L, Lozano-Rodríguez, R, Avendaño-Ortiz, J, Arcos, V, Montalbán-Hernández, K, Quiroga, J, Pascual-Iglesias, A, Maroun-Eid, C, Martín-Quirós, A, Namkoong, H, Imoto, S, Katayama, K, Fukunaga, K, Kitagawa, Y, Sato, T, Hasegawa, N, Kumanogoh, A, Kimura, A, Ai, M, Tokunaga, K, Kanai, T, Miyano, S, Ogawa, S, Edahiro, R, Sonehara, K, Shirai, Y, Ishii, M, Kabata, H, Masaki, K, Kamata, H, Ikemura, S, Chubachi, S, Okamori, S, Terai, H, Tanaka, H, Morita, A, Asakura, T, Sasaki, J, Morisaki, H, Uwamino, Y, Nanki, K, Mikami, Y, Tomono, K, Kato, K, Matsuda, F, Takahashi, M, Hizawa, N, Takeda, Y, Hirata, H, Shiroyama, T, Miyawaki, S, Suzuki, K, Maeda, Y, Nii, T, Noda, Y, Niitsu, T, Adachi, Y, Enomoto, T, Amiya, S, Hara, R, Takahashi, K, Anzai, T, Hasegawa, T, Ito, S, Koike, R, Endo, A, Uchimura, Y, Miyazaki, Y, Honda, T, Tateishi, T, Tohda, S, Ichimura, N, Sonobe, K, Sassa, C, Nakajima, J, Nannya, Y, Omae, Y, Harada, N, Hiki, M, Takagi, H, Nakamura, A, Tagaya, E, Kawana, M, Arimura, K, Ishiguro, T, Takayanagi, N, Isono, T, Takaku, Y, Takano, K, Anan, R, Nakajima, Y, Nakano, Y, Nishio, K, Ueda, S, Hayashi, R, Tateno, H, Hase, I, Yoshida, S, Suzuki, S, Mitamura, K, Saito, F, Ueda, T, Azuma, M, Nagasaki, T, Yasui, Y, Hasegawa, Y, Mutoh, Y, Yoshiyama, T, Shoko, T, Kojima, M, Adachi, T, Ishikawa, M, Watanabe, K, Manabe, T, Ito, F, Fukui, T, Funatsu, Y, Koh, H, Hirai, Y, Kawashima, H, Narita, A, Niwa, K, Sekikawa, Y, Yoshiya, K, Yoshihara, T, Suzuki, Y, Nakayama, S, Masuzawa, K, Nishi, K, Nishitsuji, M, Tani, M, Inoue, T, Hirano, T, Kobayashi, K, Miyazawa, N, Kimura, Y, Sado, R, Ogura, T, Kitamura, H, Murohashi, K, Nakachi, I, Baba, R, Arai, D, Fuke, S, Saito, H, Kuwahara, N, Fujiwara, A, Okada, T, Baba, T, Noda, J, Mashimo, S, Yagi, K, Shiomi, T, Hashiguchi, M, Odani, T, Mochimaru, T, Oyamada, Y, Mori, N, Izumi, N, Nagata, K, Taki, R, Murakami, K, Yamada, M, Sugiura, H, Hayashi, K, Shimizu, T, Gon, Y, Fujitani, S, Tsuchida, T, Yoshida, T, Kagaya, T, Kita, T, Sakagami, S, Kimizuka, Y, Kawana, A, Nakamura, Y, Ishikura, H, Takata, T, Kikuchi, T, Taniyama, D, Nakamura, M, Kodama, N, Kaneyama, Y, Maeda, S, Nagasaki, Y, Okamoto, M, Ishihara, S, Ito, A, Chihara, Y, Takeuchi, M, Onoi, K, Hashimoto, N, Wakahara, K, Ando, A, Masuda, M, Wakabayashi, A, Watanabe, H, Sageshima, H, Nakada, T, Abe, R, Shimada, T, Kawamura, K, Ichikado, K, Nishiyama, K, Yamasaki, M, Hashimoto, S, Kusaka, Y, Ohba, T, Isogai, S, Takada, M, Kanda, H, Komase, Y, Sano, F, Asano, K, Oguma, T, Harada, M, Takahashi, T, Shibusawa, T, Abe, S, Kono, Y, Togashi, Y, Izumo, T, Inomata, M, Awano, N, Ogata, T, Kanehiro, A, Ozaki, S, Fuchimoto, Y, Ogura, S, Yoshida, K, Beppu, S, Fukuyama, S, Eriguchi, Y, Yonekawa, A, Inoue, Y, Yamagata, K, Chiba, S, Narumoto, O, Nagai, H, Ooshima, N, Motegi, M, Sagara, H, Tanaka, A, Ohta, S, Shibata, Y, Tanino, Y, Sato, Y, Yamada, Y, Hashino, T, Shinoki, M, Iwagoe, H, Imamura, T, Umeda, A, Shimada, H, Endo, M, Hayashi, S, Nakano, S, Yatomi, M, Maeno, T, Ishii, T, Utsugi, M, Ono, A, Kanaoka, K, Ihara, S, Komuta, K, Boezen, M, Claringbould, A, Lopera, E, Warmerdam, R, Vonk, J, van Blokland, I, Lanting, P, Ori, A, Obeidat, M, Hernández Cordero, A, Sin, D, Bossé, Y, Joubert, P, Hao, K, Nickle, D, Timens, W, van den Berge, M, Feng, Y, Weiss, S, Karlson, E, Smoller, J, Murphy, S, Meigs, J, Woolley, A, Green, R, Perez, E, Zöllner, S, Wang, J, Beck, A, Ascolillo, S, Sebra, R, Collins, B, Levy, T, Sealfon, S, Jordan, D, Thompson, R, Gettler, K, Chaudhary, K, Belbin, G, Preuss, M, Hoggart, C, Choi, S, Underwood, S, Salib, I, Britvan, B, Keller, K, Tang, L, Peruggia, M, Hiester, L, Niblo, K, Aksentijevich, A, Labkowsky, A, Karp, A, Zlatopolsky, M, Zyndorf, M, Charney, A, Beckmann, N, Schadt, E, Abul-Husn, N, Cho, J, Itan, Y, Kenny, E, Loos, R, Nadkarni, G, Do, R, O’Reilly, P, Huckins, L, Ferreira, M, Abecasis, G, Leader, J, Cantor, M, Justice, A, Carey, D, Chittoor, G, Josyula, N, Kosmicki, J, Horowitz, J, Baras, A, Gass, M, Yadav, A, Mirshahi, T, Jan Hottenga, J, Bartels, M, de Geus, E, Nivard, M, Verma, A, Ritchie, M, Rader, D, Li, B, Verma, S, Lucas, A, Bradford, Y, Zara, F, Salpietro, V, Scala, M, Iacomino, M, Scudieri, P, Bocciardi, R, Minetti, C, Vari, M, Rahier, J, Giorgio, E, Carli, D, Louis, E, Bulik, C, Landén, M, Brusco, A, Ferrero, G, Madia, F, Fundín, B, Ismail, S, Saad, C, Al-Sarraj, Y, Badji, R, Al-Muftah, W, Al Thani, A, Afifi, N, Klovins, J, Rovite, V, Rescenko, R, Peculis, R, Ustinova, M, Zeberg, H, Frithiof, R, Hultström, M, Lipcsey, M, Johnson, R, Geschwind, D, Freimer, N, Butte, M, Ding, Y, Chiu, A, Chang, T, Boutros, P, Moutsianas, L, Caulfield, M, Scott, R, Walker, S, Stuckey, A, Odhams, C, Rhodes, D, Fowler, T, Rendon, A, Chan, G, Arumugam, P, Karczewski, K, Wilson, D, Spencer, C, Crook, D, Wyllie, D, O’Connell, A, Atkinson, E, Tsuo, K, Baya, N, Turley, P, Gupta, R, Walters, R, Palmer, D, Sarma, G, Cheng, N, Lu, W, Churchhouse, C, Goldstein, J, King, D, Seed, C, Bryant, S, Satterstrom, F, Band, G, Earle, S, Lin, S, Arning, N, Armstrong, J, Rudkin, J, Callier, S, Cusick, C, Soranzo, N, Zhao, J, Danesh, J, Di Angelantonio, E, Butterworth, A, Sun, Y, Huffman, J, Cho, K, O’Donnell, C, Tsao, P, Gaziano, J, Peloso, G, Ho, Y, Mian, M, Scaggiante, F, Chang, X, Glessner, J, Hakonarson, H, Mcguigan, P, Prockter Moore, L, Vizcaychipi, M, Hall, K, Campbell, A, Nichol, A, Ward, G, Page, V, Semple, M, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Aldera, E, Alegria, A, Angus, B, Ashish, A, Atkinson, D, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Basude, S, Baxter, D, Beadsworth, M, Bernatoniene, J, Berridge, J, Best, N, Bothma, P, Chadwick, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Child, J, Chukkambotla, S, Clark, T, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M, Dark, P, Dawson, C, Dervisevic, S, Donnison, P, Douthwaite, S, Drummond, A, Durand, I, Dushianthan, A, Dyer, T, Evans, C, Eziefula, C, Fegan, C, Finn, A, Fullerton, D, Garg, S, Garg, A, Gkrania-Klotsas, E, Godden, J, Goldsmith, A, Graham, C, Hardy, E, Hartshorn, S, Harvey, D, Havalda, P, Hawcutt, D, Hobrok, M, Hodgson, L, Hormis, A, Jacobs, M, Jain, S, Jennings, P, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kendall, J, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Laha, S, Laird, S, Larkin, S, Leiner, T, Lillie, P, Limb, J, Linnett, V, Little, J, Lyttle, M, Macmahon, M, Macnaughton, E, Mankregod, R, Masson, H, Matovu, E, Mccullough, K, Mcewen, R, Meda, M, Mills, G, Minton, J, Ward, K, Mirfenderesky, M, Mohandas, K, Mok, Q, Moon, J, Moore, E, Morgan, P, Morris, C, Mortimore, K, Moses, S, Mpenge, M, Mulla, R, Murphy, M, Nagel, M, Nagarajan, T, Nelson, M, O’Shea, M, Otahal, I, Ostermann, M, Pais, M, Panchatsharam, S, Papakonstantinou, D, Paraiso, H, Patel, B, Pattison, N, Pepperell, J, Peters, M, Phull, M, Pintus, S, Pooni, J, Post, F, Price, D, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Roberts, M, Roberts, D, Rose, A, Rousseau, G, Ryan, B, Saluja, T, Shah, A, Shanmuga, P, Sharma, A, Shawcross, A, Sizer, J, Shankar-Hari, M, Smith, R, Snelson, C, Spittle, N, Staines, N, Stambach, T, Stewart, R, Subudhi, P, Szakmany, T, Tatham, K, Thomas, J, Thompson, C, Tridente, A, Tupper-Carey, D, Twagira, M, Ustianowski, A, Vallotton, N, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Walden, A, Welters, I, Whitehouse, T, Whittaker, P, Whittington, A, Papineni, P, Wijesinghe, M, Williams, M, Wilson, L, Cole, S, Winchester, S, Wiselka, M, Wolverson, A, Wooton, D, Workman, A, Yates, B, Young, P, Beale, R, Bretherick, A, Clohisey, S, Fourman, M, Furniss, J, Gountouna, E, Grimes, G, Haley, C, Harrison, D, Hayward, C, Keating, S, Klaric, L, Klenerman, P, Law, A, Meynert, A, Millar, J, Pairo-Castineira, E, Parkinson, N, Ponting, C, Porteous, D, Rawlik, K, Richmond, A, Rowan, K, Russell, C, Shen, X, Shih, B, Tenesa, A, Vitart, V, Wang, B, Wilson, J, Wu, Y, Yang, J, Yang, Z, Zechner, M, Zhai, R, Zheng, C, Norman, L, Pius, R, Drake, T, Fairfield, C, Mclean, K, Murphy, D, Shaw, C, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Leeming, G, Wham, M, Hendry, R, Scott-Brown, J, Begg, C, Hinds, C, Wai Ho, A, Horby, P, Knight, J, Ling, L, Maslove, D, Mcauley, D, Montgomery, H, Openshaw, P, Summers, C, Walsh, T, Armstrong, L, Bates, H, Dooks, E, Farquhar, F, Hairsine, B, Mcparland, C, Packham, S, Alldis, Z, Astin-Chamberlain, R, Bibi, F, Biddle, J, Blow, S, Bolton, M, Borra, C, Bowles, R, Burton, M, Choudhury, Y, Collier, D, Cox, A, Easthope, A, Ebano, P, Fotiadis, S, Gurasashvili, J, Halls, R, Hartridge, P, Kallon, D, Kassam, J, Lancoma-Malcolm, I, Matharu, M, May, P, Mitchelmore, O, Newman, T, Patel, M, Pheby, J, Pinzuti, I, Prime, Z, Prysyazhna, O, Shiel, J, Taylor, M, Tierney, C, Wood, S, Zak, A, Zongo, O, Forsey, M, Nicholson, A, Riches, J, Vertue, M, Wasson, C, Finn, S, Green, J, Collins, E, King, B, Grauslyte, L, Hussain, M, Pogreban, T, Rosaroso, L, Salciute, E, Franke, G, Wong, J, George, A, Akeroyd, L, Bano, S, Bromley, M, Gurr, L, Lawton, T, Morgan, J, Sellick, K, Warren, D, Wilkinson, B, Mcgowan, J, Ledgard, C, Stacey, A, Pye, K, Bellwood, R, Bentley, M, Loosley, R, Mcguinness, H, Tench, H, Wolf-Roberts, R, Gibson, S, Lyle, A, Mcneela, F, Radhakrishnan, J, Hughes, A, Ali, A, Brady, M, Dale, S, Dance, A, Gledhill, L, Greig, J, Hanson, K, Holdroyd, K, Home, M, Kelly, D, Kitson, R, Matapure, L, Melia, D, Mellor, S, Nortcliffe, T, Pinnell, J, Robinson, M, Shaw, L, Shaw, R, Thomis, L, Wilson, A, Wood, T, Bayo, L, Merwaha, E, Ishaq, T, Hanley, S, Antcliffe, D, Banach, D, Brett, S, Coghlan, P, Fernandez, Z, Gordon, A, Rojo, R, Arias, S, Templeton, M, Jha, R, Krishnamurthy, V, Lim, L, Bi, R, Scholefield, B, Ashton, L, Williams, A, Cheyne, C, Saunderson, A, Allan, A, Anderson, F, Kaye, C, Liew, J, Medhora, J, Scott, T, Trumper, E, Botello, A, Polgarova, P, Stroud, K, Meaney, E, Jones, M, Ng, A, Agrawal, S, Pathan, N, White, D, Daubney, E, Elston, K, Parker, R, Reddy, A, Turner-Bone, I, Wilding, L, Harding, P, Jacob, R, Jones, C, Denmade, C, Croft, M, White, I, Griffin, D, Muchenje, N, Mupudzi, M, Partridge, R, Conyngham, J, Thomas, R, Wright, M, Corral, M, Bastion, V, Clarke, D, David, B, Kent, H, Lorusso, R, Lubimbi, G, Murdoch, S, Penacerrada, M, Thomas, A, Valentine, J, Vochin, A, Wulandari, R, Djeugam, B, Dawson, J, Garrioch, S, Tolson, M, Aldridge, J, de Almeida Martins, L, Carungcong, J, Beavis, S, Dale, K, Gascoyne, R, Hawes, J, Pritchard, K, Stevenson, L, Whileman, A, Cowley, A, Highgate, J, Crawley, R, Crew, A, Cunningham, M, Daniels, A, Harrison, L, Hope, S, Inweregbu, K, Jones, S, Lancaster, N, Matthews, J, Wray, G, Benham, L, Bradshaw, Z, Brown, J, Caswell, M, Melling, S, Preston, S, Slawson, N, Stoddard, E, Warden, S, Combes, E, Joefield, T, Monnery, S, Beech, V, Trotman, S, Hopkins, B, Scriven, J, Thrasyvoulou, L, Willis, H, Anderson, S, Birch, J, Hammerton, K, O’Leary, R, Abernathy, C, Foster, L, Gratrix, A, Martinson, V, Parkinson, P, Stones, E, Carbral-Ortega, L, Kapoor, R, Loader, D, Castle, K, Brandwood, C, Smith, L, Clark, R, Birchall, K, Kolakaluri, L, Baines, D, Sukumaran, A, Mapfunde, I, Meredith, M, Morris, L, Ryan, L, Clark, A, Sampson, J, Peters, C, Dent, M, Langley, M, Wei, S, Andrew, A, Chablani, M, Kirkby, A, Netherton, K, Bates, M, Dasgin, J, Gill, J, Nilsson, A, Apetri, E, Basikolo, C, Blackledge, B, Catlow, L, Charles, B, Doonan, R, Harris, J, Harvey, A, Horner, D, Knowles, K, Lomas, D, Lyons, C, Marsden, T, Mclaughlan, D, Mcmorrow, L, Pendlebury, J, Perez, J, Poulaka, M, Proudfoot, N, Slaughter, M, Slevin, K, Thomas, V, Walker, D, Michael, A, Collis, M, Clark, M, Coulding, M, Jude, E, Mccormick, J, Mercer, O, Potla, D, Rehman, H, Savill, H, Turner, V, Davey, M, Golden, D, Seaman, R, Hunt, J, Dearden, J, Dobson, E, Mulcahy, M, Munt, S, O’Connor, G, Philbin, J, Rishton, C, Tully, R, Winnard, S, Cagova, L, Fofano, A, Garner, L, Holcombe, H, Mepham, S, Mitchell, A, Mwaura, L, Praman, K, Zamikula, J, Bercades, G, Brealey, D, Hass, I, Maccallum, N, Martir, G, Raith, E, Reyes, A, Smyth, D, Taylor, A, Hughes, R, Thomas, H, Rees, A, Duskova, M, Phipps, J, Brooks, S, Edwards, M, Alexander, P, Allen, S, Bradley-Potts, J, Brantwood, C, Egan, J, Felton, T, Padden, G, Ward, L, Moss, S, Glasgow, S, Beesley, K, Board, S, Kubisz-Pudelko, A, Lewis, A, Perry, J, Pippard, L, Wood, D, Buckley, C, Brown, A, Gregory, J, O’Connell, S, Smith, T, Belagodu, Z, Fuller, B, Gherman, A, Olufuwa, O, Paramsothy, R, Stuart, C, Oakley, N, Kamundi, C, Tyl, D, Collins, K, Silva, P, Taylor, J, King, L, Coates, C, Crowley, M, Wakefield, P, Beadle, J, Johnson, L, Sargeant, J, Anderson, M, Jardine, C, Williams, D, Parris, V, Quaid, S, Watson, E, Melville, J, Naisbitt, J, Joseph, R, Lazo, M, Walton, O, Neal, A, Hill, M, Kannan, T, Wild, L, Allan, E, Darlington, K, Davies, F, Easton, J, Kumar, S, Lean, R, Menzies, D, Pugh, R, Qiu, X, Davies, L, Williams, H, Scanlon, J, Davies, G, Mackay, C, Lewis, J, Rees, S, Coetzee, S, Gales, A, Raj, M, Sell, C, Langton, H, Watters, M, Novis, C, Arbane, G, Bociek, A, Campos, S, Grau, N, Jones, T, Lim, R, Marotti, M, Whitton, C, Barron, A, Collins, C, Kaul, S, Passmore, H, Prendergast, C, Reed, A, Rogers, P, Shokkar, R, Woodruff, M, Middleton, H, Polgar, O, Nolan, C, Thwaites, V, Mahay, K, Sri-Chandana, C, Scherewode, J, Stephenson, L, Marsh, S, Bancroft, H, Bellamy, M, Carmody, M, Daglish, J, Moore, F, Rhodes, J, Sangombe, M, Kadiri, S, Ayers, A, Harrison, W, North, J, Cavazza, A, Cockrell, M, Corcoran, E, Depante, M, Finney, C, Jerome, E, Mcphail, M, Nayak, M, Noble, H, O’Reilly, K, Pappa, E, Saha, R, Saha, S, Smith, J, Knighton, A, Gill, M, Paul, P, Ratnam, V, Shelton, S, Wynter, I, Baptista, D, Crowe, R, Fernandes, R, Herdman-Grant, R, Joseph, A, Loveridge, A, Mckenley, I, Morino, E, Naranjo, A, Simms, R, Sollesta, K, Swain, A, Venkatesh, H, Khera, J, Fox, J, Barber, R, Hewitt, C, Hilldrith, A, Jackson-Lawrence, K, Shepardson, S, Wills, M, Butler, S, Tavares, S, Cunningham, A, Hindale, J, Arif, S, George, L, Twiss, S, Wright, D, Holland, M, Keenan, N, Lyons, M, Wassall, H, Marsh, C, Mahenthran, M, Carter, E, Kong, T, Adanini, O, Bhatia, N, Msiska, M, Mew, L, Mwaura, E, Williams, F, Wren, L, Sutherland, S, Battle, C, Brinkworth, E, Harford, R, Murphy, C, Newey, L, Rees, T, Arnold, S, Hardy, J, Houlden, H, Moncur, E, Tariq, A, Tucci, A, Convery, K, Fottrell-Gould, D, Hudig, L, Keshet-Price, J, Randell, G, Stammers, K, Abdelrazik, M, Bakthavatsalam, D, Elhassan, M, Ganesan, A, Haldeos, A, Moreno-Cuesta, J, Purohit, D, Vincent, R, Xavier, K, Rohit, K, Alasdair, F, Saleem, M, David, C, Jenkins, S, Lamond, Z, Wall, A, Reynolds, J, Campbell, H, Thompsom, M, Dodds, S, Duffy, S, Butcher, D, O’Sullivan, S, Butterworth-Cowin, N, Deacon, B, Hibbert, M, Pothecary, C, Tetla, D, Woodford, C, Durga, L, Kennard-Holden, G, de Gordoa, L, Peasgood, E, Phillips, C, Skinner, D, Gaylard, J, Mullan, D, Newman, J, Davies, E, Roche, L, Sathe, S, Brimfield, L, Daly, Z, Pogson, D, Rose, S, Collins, A, Khaliq, W, Gude, E, Allen, L, Beranova, E, Crisp, N, Deery, J, Hazelton, T, Knight, A, Price, C, Tilbey, S, Turki, S, Turney, S, Giles, J, Booth, S, Bell, G, English, K, Katary, A, Wilcox, L, Campbell, R, Clarke, N, Whiteside, J, Mascarenhas, M, Donaldson, A, Matheson, J, Barrett, F, O’Hara, M, O’Keefe, L, Bradley, C, Walker, R, Maynard, V, Patel, T, Smith, M, Kazi, A, Hartley, J, Dykes, J, Hijazi, M, Keith, S, Khan, M, Ryan-Smith, J, Springle, P, Truman, N, Saad, S, Coleman, D, Fine, C, Matt, R, Gay, B, Dalziel, J, Ali, S, Goodchild, D, Harling, R, Bhatterjee, R, Goddard, W, Davison, C, Duberly, S, Hargreaves, J, Bolton, R, Verlander, M, Blackman, H, Creagh-Brown, B, Donlon, S, Michalak-Glinska, N, Mtuwa, S, Pristopan, V, Salberg, A, Smith, E, Stone, S, Piercy, C, Verula, J, Burda, D, Montaser, R, Harden, L, Mayangao, I, Marriott, C, Bradley, P, Harris, C, Cooper, J, Finch, C, Liderth, S, Quinn, A, Waddington, N, Fidler, K, Tagliavini, E, Donnelly, K, Abel, L, Brett, M, Digby, B, Gemmell, L, Hornsby, J, Macgoey, P, O’Neil, P, Price, R, Rodden, N, Rooney, K, Sundaram, R, Thomson, N, Flanagan, R, Hughes, G, Latham, S, Mckenna, E, Anderson, J, Hull, R, Rhead, K, Branney, D, Frankham, J, Pitts, S, White, N, Cristiano, D, Dormand, N, Farzad, Z, Gummadi, M, Liyanage, K, Salmi, S, Sloane, G, Varghese, M, Zborowski, A, Bean, S, Burt, K, Spivey, M, Eastgate-Jackson, C, Filipe, H, Martin, D, Maharajh, A, Garcia, S, De Neef, M, Lynch, C, Howe, G, Singh, J, Turner, K, Ellis, H, Stroud, N, Cherian, S, Cutler, S, Heron, A, Roynon-Reed, A, Williams, G, Richards, O, Cheema, Y, Ahmad, N, Barker, J, Bauchmuller, K, Bird, S, Cawthron, K, Harrington, K, Jackson, Y, Kibutu, F, Lenagh, B, Masuko, S, Raithatha, A, Wiles, M, Willson, J, Newell, H, Lye, A, Nwafor, L, Jarman, C, Rowland-Jones, S, Foote, D, Cole, J, Watson, J, Hesseldon, L, Macharia, I, Chetam, L, Ford, A, Housley, K, Milner, L, Hanratty, H, Trower, H, Phillips, P, Oxspring, S, Donne, B, Bevan, E, Martin, J, Trodd, D, Watson, G, Brown, C, Bunni, L, Jennings, C, Latif, M, Marshall, R, Subramanian, G, Bandla, N, Gellamucho, M, Davies, M, Trim, F, Eapen, B, Ahmed, C, Baines, B, Clamp, S, Colley, J, Haq, R, Hayes, A, Hulme, J, Joseph, S, Kumar, R, Maqsood, Z, Purewal, M, Chandler, B, Elliott, K, Mallinson, J, Turnbull, A, Dent, K, Horsley, E, Akhtar, M, Pearson, S, Potoczna, D, Spencer, S, Blakemore, H, Borislavova, B, Faulkner, B, Gendall, E, Goff, E, Hayes, K, Thomas, M, Worner, R, Smith, K, Stephens, D, Delgado, C, Dawson, D, Ding, L, Durrant, G, Ezeobu, O, Farnell-Ward, S, Harrison, A, Kanu, R, Leaver, S, Maccacari, E, Manna, S, Saluzzio, R, Queiroz, J, Samakomva, T, Sicat, C, Texeira, J, Da Gloria, E, Lisboa, A, Rawlins, J, Mathew, J, Kinch, A, Hurt, W, Shah, N, Clark, V, Thanasi, M, Yun, N, Patel, K, Crickmore, V, Debreceni, G, Wilkins, J, Nicol, L, Burn, I, Hambrook, G, Manso, K, Penn, R, Shanmugasundaram, P, Tebbutt, J, Thornton, D, Rostron, A, Roy, A, Woods, L, Cornell, S, Wakinshaw, F, Rogerson, K, Jarmain, J, Anderson, P, Archer, K, Austin, K, Davis, C, Durie, A, Kelsall, O, Thrush, J, Vigurs, C, Wood, H, Tranter, H, Cowley, N, Mcalindon, M, Digby, S, Low, E, Morgan, A, Cother, N, Rankin, T, Clayton, S, Mccurdy, A, Allibone, S, Mary-Genetu, R, Patel, A, Mac, A, Murphy, A, Mahjoob, P, Nazari, R, Worsley, L, Fagan, A, Mohamed Ali, I, Beaumont, K, Blunt, M, Coton, Z, Curgenven, H, Elsaadany, M, Fernandes, K, Ally, S, Rangarajan, H, Sarathy, V, Selvanayagam, S, Vedage, D, White, M, Fernandez-Roman, J, Hamilton, D, Johnson, E, Johnston, B, Martinez, M, Mulla, S, Waite, A, Waugh, V, Williams, K, Bemand, T, Black, E, Rosa, A, Howle, R, Jhanji, S, Baikady, R, Thomas, B, Halkes, M, Mercer, P, Thornton, L, West, J, Baird, T, Ruddy, J, Reece-Anthony, R, Birt, M, Cowton, A, Kay, A, Kent, M, Potts, K, Wilkinson, A, Naylor, S, Brown, E, Purvis, S, Davies, R, Duffin, D, Hill, H, Player, B, Thomas, E, Beith, C, Black, K, Clements, S, Morrison, A, Strachan, D, Clarkson, M, D’Sylva, S, Norman, K, Coventry, T, Fowler, S, Mcgregor, A, Brady, A, Chan, R, Mcivor, S, Prady, H, Whittle, H, Mathew, B, Clapham, M, Harper, R, Poultney, U, Rice, P, Mutch, R, Baird, Y, Butler, A, Chadbourn, I, Folkes, L, Fox, H, Gardner, A, Gomez, R, Hobden, G, King, K, Margarson, M, Martindale, T, Meadows, E, Raynard, D, Thirlwall, Y, Helm, D, Margalef, J, Greer, S, Shuker, K, Smuts, S, Duffield, J, Smith, O, Mallon, L, Claire, W, Birkinshaw, I, Carter, J, Howard, K, Ingham, J, Joy, R, Pearson, H, Roche, S, Scott, Z, Knights, E, Price, A, Thorpe, C, Abraheem, A, Bamford, P, Cawley, K, Dunmore, C, Faulkner, M, Girach, R, Jeffrey, H, Jones, R, London, E, Nagra, I, Nasir, F, Sainsbury, H, Smedley, C, Khade, R, Sundar, A, Tsinaslanidis, G, Behan, T, Burnett, C, Hatton, J, Heeney, E, Mitra, A, Newton, M, Pollard, R, Stead, R, Bough, L, Goodsell, J, Tutton, R, Williams, P, Williams, S, Winter-Goodwin, B, Auld, F, Donnachie, J, Edmond, I, Prentice, L, Runciman, N, Salutous, D, Symon, L, Todd, A, Turner, P, Short, A, Sweeney, L, Murdoch, E, Senaratne, D, Burns, K, Higham, A, Anderson, T, O’Malley, L, Rad, L, Rogers, N, Saunderson, P, Allison, K, Afolabi, D, Whitbread, J, Jones, D, Dore, R, Lankester, L, Nikitas, N, Wells, C, Stowe, B, Spencer, K, Cathcart, S, Duffy, K, Puxty, A, Puxty, K, Turner, L, Ireland, J, Semple, G, Barry, P, Hilltout, P, Evitts, J, Tyler, A, Waldron, J, Irvine, V, Shelley, B, Akinkugbe, O, Bamford, A, Beech, E, Belfield, H, Bell, M, Davies, C, Jones, G, Mchugh, T, Meghari, H, O’Neill, L, Ray, S, Tomas, A, Gorman, C, Gupta, A, Timlick, E, Brady, R, Bonner, S, Hugill, K, Jones, J, Liggett, S, Bashyal, A, Davidson, N, Hutton, P, Mckechnie, S, Flint, N, Rekha, P, Hales, D, Cruz, C, Gopal, S, Harris, N, Lake, V, Metherell, S, Radford, E, Clement, I, Gulati, A, Hays, C, Webster, K, Hudson, A, Webster, A, Stephenson, E, Mccormack, L, Slater, V, Nixon, R, Hanson, H, Fearby, M, Kelly, S, Bridgett, V, Robinson, P, Almaden-Boyle, C, Austin, P, Cabrelli, L, Casey, M, Chapman, S, Whyte, C, Brayne, A, Fisher, E, Jackson, P, Kaye, D, Love, N, Parkin, J, Tuckey, V, van Koutrik, L, Carter, S, Andrew, B, Findlay, L, Adams, K, Bruce, M, Connolly, K, Duncan, T, T. -Michael, H, Lindergard, G, Hey, S, Fox, C, Alfonso, J, Durrans, L, Guerin, J, Hruska, M, Eltayeb, A, Lamb, T, Hodgkiss, T, Cooper, L, Rothwell, J, Dennis, C, Srikaran, S, Sukha, A, Davies, K, O’Brien, L, Omar, Z, Perkins, E, Lewis, T, Sutherland, I, Brooke, H, Buckley, S, Suarez, J, Charlesworth, R, Hansson, K, Norris, J, Poole, A, Sandhu, R, Sloan, B, Smithson, E, Thirumaran, M, Wagstaff, V, Metcalfe, A, Camsooksai, J, Humphrey, C, Wadams, B, Death, Y, Adams, C, Agasou, A, Arden, T, Bowes, A, Boyle, P, Beekes, M, Button, H, Capps, N, Carnahan, M, Carter, A, Childs, D, Donaldson, D, Hard, K, Hurford, F, Hussain, Y, Javaid, A, Jose, S, Leigh, M, Martin, T, Millward, H, Motherwell, N, Rikunenko, R, Stickley, J, Summers, J, Ting, L, Tivenan, H, Tonks, L, Wilcox, R, Bokhari, M, Lucas, R, Mccormick, W, Ritzema, J, Sanderson, A, Wild, H, Baxter, N, Henderson, S, Kennedy-Hay, S, Rooney, L, Sim, M, Mccreath, G, Brunton, M, Caterson, J, Coles, H, Frise, M, Rai, S, Keating, L, Tilney, E, Bartley, S, Bhuie, P, Downes, C, Holding, K, Riches, K, Hilton, M, Hayman, M, Subramanian, D, Daniel, P, Zitter, L, Benyon, S, Marriott, S, Park, L, Keenan, S, Gordon, E, Quinn, H, Baines, K, Andrew, G, Barclay, L, Callaghan, M, Clark, S, Hope, D, Marshall, L, Mcculloch, C, Briton, K, Singleton, J, Birch, S, Simpson, K, Craig, J, Demetriou, C, Eckbad, C, Hierons, S, Howie, L, Mitchard, S, Ramos, L, Serrano-Ruiz, A, White, K, Kelly, F, Amin, V, Anastasescu, E, Anumakonda, V, Karthik, K, Kausar, R, Reid, K, Imeson-Wood, J, Bellini, A, Bryant, J, Pickard, A, Roe, N, Sowter, J, Howlett, A, Criste, K, Cusack, R, Golder, K, Golding, H, Jones, O, Leggett, S, Male, M, Marani, M, Prager, K, Williams, T, Roberts, B, Salmon, K, Gondo, P, Hadebe, B, Kayani, A, Masunda, B, Ahmed, A, Morris, A, Jakkula, S, Long, K, Whiteley, S, Wilby, E, Ogg, B, Moultrie, S, Odam, M, Bewley, J, Garland, Z, Grimmer, L, Gumbrill, B, Sweet, K, Webster, D, Efford, G, Bennett, S, Goodwin, E, Jackson, M, Kent, A, Tibke, C, Woodyatt, W, Zaki, A, Daniel, A, Finn, J, Bremmer, P, Allan, J, Geary, T, Houston, G, Meikle, A, O’Brien, P, Bell, D, Boyle, R, Douglas, K, Glass, L, Lee, E, Lennon, L, Rattray, A, Charnock, R, Mcfarland, D, Cosgrove, D, Attwood, B, Parsons, P, Carmody, S, Oblak, M, Popescu, M, Thankachen, M, Baruah, R, Morris, S, Ferguson, S, Shepherd, A, Altabaibeh, A, Alvaro, A, Gilbert, K, Ma, L, Mostoles, L, Parmar, C, Jetha, C, Booker, L, Pratley, A, Cosier, T, Millen, G, Schumacher, N, Weston, H, Rand, J, Alex, B, Bach, B, Barclay, W, Bogaert, D, Chand, M, Cooke, G, Docherty, A, Dunning, J, da Silva Filipe, A, Fletcher, T, Green, C, Harrison, E, Hiscox, J, Ijaz, S, Khoo, S, Lim, W, Mentzer, A, Merson, L, Noursadeghi, M, Moore, S, Palmarini, M, Paxton, W, Pollakis, G, Price, N, Rambaut, A, Robertson, D, Sancho-Shimizu, V, Scott, J, de Silva, T, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Tedder, R, Thomson, E, Roger Thompson, A, Thwaites, R, Turtle, L, Palmieri, C, Swann, O, Zambon, M, Dumas, M, Griffin, J, Takats, Z, Chechi, K, Andrikopoulos, P, Osagie, A, Olanipekun, M, Liggi, S, Lewis, M, Correia, G, Sands, C, Takis, P, Maslen, L, Greenhalf, W, Shaw, V, Mcdonald, S, Ahmed, K, Ashworth, M, Asiimwe, I, Bakshi, S, Barlow, S, Booth, L, Brennan, B, Bullock, K, Catterall, B, Clark, J, Clarke, E, Cox, H, Dincarslan, O, Dunn, C, Dyer, P, Elliott, A, Evans, A, Finch, L, Fisher, L, Foster, T, Garcia-Dorival, I, Gunning, P, Hartley, C, Jensen, R, Khandaker, S, Kiy, R, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, L, Mancini, M, Mcevoy, L, Mclauchlan, J, Metelmann, S, Miah, N, Middleton, J, Mitchell, J, Murphy, E, Penrice-Randal, R, Pilgrim, J, Prince, T, Reynolds, W, Ridley, P, Sales, D, Shears, R, Small, B, Subramaniam, K, Szemiel, A, Taggart, A, Tanianis-Hughes, J, Trochu, E, van Tonder, L, Wilcock, E, Zhang, J, Flaherty, L, Maziere, N, Cass, E, Carracedo, A, Carlucci, N, Holmes, A, Massey, H, Murphy, L, Wrobel, N, Mccafferty, S, Morrice, K, Maclean, A, Armstrong, R, Boz, C, Coutts, A, Cullum, L, Day, N, Donnelly, L, Duncan, E, Fawkes, A, Finernan, P, Gilchrist, T, Golightly, A, Hafezi, K, Law, D, Law, R, Law, S, Macgillivray, L, Mal, H, Mcmaster, E, Meikle, J, Oosthuyzen, W, Paterson, T, Stenhouse, A, Swets, M, Szoor-McElhinney, H, Taneski, F, Wackett, T, Ward, M, Weaver, J, Coyle, J, Gallagher, B, Lidstone-Scott, R, Schon, K, Furlong, A, Biggs, H, Griffiths, F, Andrews, E, Brickell, K, Smyth, M, Carson, G, Hardwick, H, Donohue, C, COVID-19 Host Genetics Initiative, Karjalainen, J., Neale, B.M., Daly, M., Ganna, A., Liao, R.G., Pathak, G.A., Andrews, S.J., Kanai, M., Veerapen, K., Fernandez-Cadenas, I., Schulte, E.C., Striano, P., Marttila, M., Minica, C., Marouli, E., Karim, M.A., Wendt, F.R., Savage, J., Sloofman, L., Butler-Laporte, G., Kim, H.N., Kanoni, S., Okada, Y., Byun, J., Han, Y., Uddin, M.J., Smith, G.D., Willer, C.J., Buxbaum, J.D., Mehtonen, J., Finucane, H., Cordioli, M., Martin, A.R., Zhou, W., Pasaniuc, B., Julienne, H., Aschard, H., Shi, H., Yengo, L., Polimanti, R., Ghoussaini, M., Schwartzentruber, J., Dunham, I., Chwialkowska, K., Francescatto, M., Trankiem, A., Balaconis, M.K., Davis, L., Lee, S., Priest, J., Renieri, A., Sankaran, V.G., van Heel, D., Deelen, P., Richards, J.B., Nakanishi, T., Biesecker, L., Kerchberger, V.E., Baillie, J.K., Mari, F., Bernasconi, A., Baillie, S.C., Canakoglu, A., Wolford, B., Faucon, A., Dutta, A.K., Schurmann, C., Harry, E., Birney, E., Nguyen, H., Nasir, J., Kaunisto, M., Solomonson, M., Dueker, N., Vadgama, N., Limou, S., Rahmouni, S., Mbarek, H., Darwish, D., Uddin, M.M., Albertos, R., Pérez-Tur, J., Li, R., Folkersen, L., Moltke, I., Koelling, N., Teumer, A., Kousathanas, A., Utrilla, A., Verdugo, R.A., Zárate, R., Medina-Gómez, C., Gómez-Cabrero, D., Carnero-Montoro, E., Cadilla, C.L., Moreno-Estrada, A., Garmendia, A., Moya, L., Sedaghati-Khayat, B., Boua, P.R., Favé, M.J., Francioli, L., Lemaçon, A., Migeotte, I., Patel, S., Varnai, R., Szentpeteri, J.L., Sipeky, C., Colombo, F., von Hohenstaufen, K., Lio, P., Vallerga, C., Wang, Q., Tanigawa, Y., Im, H., Han, C., Song, H., Lim, J., Lee, Y., Kim, S., Im, S., Atanasovska, B., Ahmad, H.F., Boer, C., Jansen, P., Franke, L., Kaja, E., Pasko, D., Kennis-Szilagyi, I., Kornilov, S.A., Prijatelj, V., Prokić, I., Sivanadhan, I., Perumal, S., Esmaeeli, S., Pearson, N.M., Auton, A., Shelton, J.F., Shastri, A.J., Filshtein-Sonmez, T., Coker, D., Symons, A., Esparza-Gordillo, J., Aslibekyan, S., O'Connell, J., Ye, C., Weldon, C.H., Perera, M., O'Leary, K., Tuck, M., O'Brien, T., Meltzer, D., O'Donnell, P., Nutescu, E., Yang, G., Alarcon, C., Herrmann, S., Mazurek, S., Banagan, J., Hamidi, Z., Barbour, A., Raffat, N., Moreno, D., Friedman, P., Ferwerda, B., van de Beek, D., Brouwer, M.C., Vlaar, APJ, Wiersinga, W.J., Posthuma, D., Tissink, E., Koos Zwinderman, A.H., Uffelmann, E., van Agtmael, M., Algera, A.G., van Baarle, F., Bax, D., Beudel, M., Jan Bogaard, H., Bomers, M., Bonta, P.I., Bos, L., Botta, M., de Brabander, J., de Bree, G., de Bruin, S., Bugiani, M., Bulle, E., Chouchane, O., Cloherty, A., Dongelmans, D., Elbers, P., Fleuren, L., Geerlings, S., Geerts, B., Geijtenbeek, T., Girbes, A., Goorhuis, B., Grobusch, M.P., Hafkamp, F., Hagens, L., Hamann, J., Harris, V., Hemke, R., Hermans, S.M., Heunks, L., Hollmann, M., Horn, J., Hovius, J.W., de Jong, M.D., Koning, R., van Mourik, N., Nellen, J., Nossent, E.J., Paulus, F., Peters, E., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, J., Reijnders, T., Schinkel, M., Schultz, M.J., Schuurman, A., Sigaloff, K., Smit, M., Stijnis, C.S., Stilma, W., Teunissen, C., Thoral, P., Tsonas, A., van der Valk, M., Veelo, D., de Vries, H., van Vugt, M., Wouters, D., Minnaar, R.P., Kromhout, A., van Uffelen, KWJ, Wolterman, R.A., Roberts, G., Park, D., Ball, C.A., Coignet, M., McCurdy, S., Knight, S., Partha, R., Rhead, B., Zhang, M., Berkowitz, N., Gaddis, M., Noto, K., Ruiz, L., Pavlovic, M., Hong, E.L., Rand, K., Girshick, A., Guturu, H., Baltzell, A.H., Guntz, J., Beguin, Y., Pigazzini, S., Nkambule, L., Bouysran, Y., Busson, A., Peyrassol, X., Wilkin, F., Pichon, B., Smits, G., Vandernoot, I., Goffard, J.C., Georges, M., Moutschen, M., Misset, B., Darcis, G., Guiot, J., Jadot, L., Azarzar, S., Dellot, P., Gofflot, S., Claassen, S., Bertrand, A., Parzibut, G., Clarinval, M., Moermans, C., Malaise, O., El Kandoussi, K., Thonon, R., Huynen, P., Mesdagh, A., Melo, S., Jacques, N., Di Valentin, E., Giroule, F., Collignon, A., Radermecker, C., Lebrun, M., Perée, H., Latour, S., Barada, O., Sanchez, J., Josse, C., Boujemla, B., Meunier, M., Mariavelle, E., Anania, S., Gazon, H., Juszczak, D., Fadeur, M., Camby, S., Meuris, C., Thys, M., Jacques, J., Henket, M., Léonard, P., Frippiat, F., Giot, J.B., Sauvage, A.S., Von Frenckell, C., Mni, M., Wéry, M., Staderoli, A., Belhaj, Y., Lambermont, B., Morrison, D.R., Mooser, V., Forgetta, V., Ghosh, B., Laurent, L., Belisle, A., Henry, D., Abdullah, T., Adeleye, O., Mamlouk, N., Kimchi, N., Afrasiabi, Z., Rezk, N., Vulesevic, B., Bouab, M., Guzman, C., Petitjean, L., Tselios, C., Xue, X., Afilalo, J., Afilalo, M., Oliveira, M., Brenner, B., Brassard, N., Durand, M., Schurr, E., Lepage, P., Ragoussis, J., Auld, D., Chassé, M., Kaufmann, D.E., Lathrop, G.M., Adra, D., Davis, L.K., Cox, N.J., Below, J.E., Sealock, J.M., Faucon, A.B., Shuey, M.M., Polikowsky, H.G., Petty, L.E., Shaw, D.M., Chen, H.H., Zhu, W., Ludwig, K.U., Schröder, J., Maj, C., Rolker, S., Nöthen, M.M., Fazaal, J., Keitel, V., Jensen, B.O., Feldt, T., Kurth, I., Marx, N., Dreher, M., Pink, I., Cornberg, M., Illig, T., Lehmann, C., Schommers, P., Augustin, M., Rybniker, J., Knopp, L., Eggermann, T., Volland, S., Altmüller, J., Berger, M.M., Brenner, T., Hinney, A., Witzke, O., Bals, R., Herr, C., Ludwig, N., Walter, J., Fuchsberger, C., Pattaro, C., De Grandi, A., Pramstaller, P., Emmert, D., Melotti, R., Foco, L., Mascalzoni, D., Gögele, M., Domingues, F., Hicks, A., Gignoux, C.R., Wicks, S.J., Crooks, K., Barnes, K.C., Daya, M., Shortt, J., Rafaels, N., Chavan, S., Goldstein, D.B., Kiryluk, K., Sengupta, S., Chung, W., Reilly, M.P., Khan, A., Wang, C., Povysil, G., Bhardwaj, N., Gharavi, A.G., Ionita-Laza, I., Shang, N., O'Byrne, S.M., Nandakumar, R., Menon, A., So, Y.S., Hod, E., Pendrick, D., Park, S.K., Kim, H.L., Kang, C.K., Lee, H.J., Song, K.H., Jae Yoon, K., Paik, N.J., Seok, W., Yoon, H., Joo, E.J., Chang, Y., Ryu, S., Park, W.B., Su Park, J., Un Park, K., Ham, S.Y., Jung, J., Kim, E.S., Kim, H.B., Ellinghaus, D., Degenhardt, F., Cáceres, M., Juzenas, S., Lenz, T.L., Albillos, A., Julià, A., Heidecker, B., Garcia, F., Kurth, F., Tran, F., Hanses, F., Zoller, H., Holter, J.C., Fernández, J., Sander, L.E., Rosenstiel, P., Koehler, P., de Cid, R., Asselta, R., Schreiber, S., Hehr, U., Prati, D., Baselli, G., Valenti, L., Bujanda, L., Banales, J.M., Duga, S., D'Amato, M., Romero-Gómez, M., Buti, M., Invernizzi, P., Franke, A., Hov, J.R., Karlsen, T.H., Folseraas, T., Maya-Miles, D., Teles, A., Azuure, C., Wacker, E.M., Uellendahl-Werth, F., ElAbd, H., Arora, J., Lerga-Jaso, J., Wienbrandt, L., Rühlemann, M.C., Wendorff, M., Vadla, M.S., Lenning, O.B., Özer, O., Myhre, R., Raychaudhuri, S., Tanck, A., Gassner, C., Hemmrich-Stanisak, G., Kässens, J., Figuera Basso, M.E., Schulzky, M., Wittig, M., Braun, N., Wesse, T., Albrecht, W., Yi, X., Ortiz, A.B., Chercoles, A.G., Ruiz, A., Mantovani, A., Holten, A.R., Mayer, A., Cherubini, A., Protti, A., Aghemo, A., Gerussi, A., Ramirez, A., Braun, A., Barreira, A., Lleo, A., Kildal, A.B., Glück, A., Nolla, A.C., Latiano, A., Dyrhol-Riise, A.M., Muscatello, A., Voza, A., Rando-Segura, A., Solier, A., Karina, B., Cortes, B., Mateos, B., Nafria-Jimenez, B., Schaefer, B., Bellinghausen, C., Ferrando, C., Quereda, C., Skurk, C., Thibeault, C., Spinner, C.D., Lange, C., Hu, C., Cappadona, C., Bianco, C., Sancho, C., Lihaug Hoff, D.A., Galimberti, D., Jiménez, D., Pestaña, D., Toapanta, D., Azzolini, E., Scarpini, E., Helbig, E.T., Urrechaga, E., Paraboschi, E.M., Pontali, E., Reverter, E., Navas, E., Arana, E., Sánchez, F.G., Ceriotti, F., Malvestiti, F., Mesonero, F., Pezzoli, G., Lamorte, G., Neb, H., My, I., Hernández, I., de Rojas, I., Galván-Femenia, I., Heyckendorf, J., Badia, J.R., Schneider, J., Goikoetxea, J., Kraft, J., Müller, K.E., Gaede, K.I., Garcia-Etxebarria, K., Tonby, K., Heggelund, L., Izquierdo-Sanchez, L., Sumoy, L., Lippert, L.J., Terranova, L., Garbarino, L., Téllez, L., Roade, L., Ostadreza, M., Intxausti, M., Kogevinas, M., Gutiérrez-Stampa, M.A., Vehreschild, MJGT, Marquié, M., Castoldi, M., Cecconi, M., Boada, M., Seilmaier, M.J., Mazzocco, M., Rodríguez-Gandía, M., Ayo, N.I., Blay, N., Martínez, N., Cornely, O.A., Palmieri, O., Tentorio, P., Rodrigues, P.M., España, P.P., Hoffmann, P., Bacher, P., Suwalski, P., de Pablo, R., Nieto, R., Badalamenti, S., Ciesek, S., Bombace, S., Wilfling, S., Brunak, S., Heilmann-Heimbach, S., Ripke, S., Bahmer, T., Landmesser, U., Protzer, U., Rimoldi, V., Skogen, V., Andrade, V., Moreno, V., Poller, W., Farre, X., Wang, X., Khodamoradi, Y., Karadeniz, Z., de Salazar, A., Palom, A., Garcia-Fernandez, A.E., Blanco-Grau, A., Zanella, A., Bandera, A., Nebel, A., Biondi, A., Caballero-Garralda, A., Gori, A., Lind, A., Fracanzani, A.L., Peschuck, A., Pesenti, A., de la Horra, C., Milani, C., Paccapelo, C., Angelini, C., Cea, C., Muñiz-Diaz, E., Sandoval, E., Calderón, E.J., Solligård, E., Aziz, F., Martinelli-Boneschi, F., Peyvandi, F., Blasi, F., Medrano, F.J., Rodriguez-Frias, F., Müller, F., Grasselli, G., Costantino, G., Cardamone, G., Foti, G., Matullo, G., Kurihara, H., Afset, J.E., Damås, J.K., Ampuero, J., Martín, J., Erdmann, J., Bergan, J., Goerg, S., Ferrusquía-Acosta, J., Quero, J.H., Delgado, J., Guerrero, J.M., Risnes, K., Bettini, L.R., Moreira, L., Gustad, L.T., Santoro, L., Scudeller, L., Riveiro-Barciela, M., Schaefer, M., Carrabba, M., Valsecchi, M.G., Hernandez-Tejero, M., Acosta-Herrera, M., D'Angiò, M., Baldini, M., Cazzaniga, M., Ciccarelli, M., Bocciolone, M., Miozzo, M., Chueca, N., Montano, N., Faverio, P., Preatoni, P., Bonfanti, P., Omodei, P., Castro, P., Ferrer, R., Gualtierotti, R., Gallego-Durán, R., Morilla, R., Haider, S., Marsal, S., Aneli, S., Pelusi, S., Bosari, S., Aliberti, S., Dudman, S., Zheng, T., Pumarola, T., Cejudo, T.G., Monzani, V., Friaza, V., Peter, W., Dopazo, X., May, S., Grimsrud, M.M., Gudbjartsson, D.F., Stefansson, K., Sulem, P., Sveinbjornsson, G., Melsted, P., Norddahl, G., Swerford Moore, K.H., Thorsteinsdottir, U., Holm, H., Alarcón-Riquelme, M.E., Bernardo, D., Martínez-Bueno, M., Rello, S.R., Magi, R., Milani, L., Metspalu, A., Laisk, T., Läll, K., Lepamets, M., Esko, T., Reimann, E., Naaber, P., Laane, E., Pesukova, J., Peterson, P., Kisand, K., Tabri, J., Allos, R., Hensen, K., Starkopf, J., Ringmets, I., Tamm, A., Kallaste, A., Alavere, H., Metsalu, K., Puusepp, M., Kristiansson, K., Koskelainen, S., Perola, M., Donner, K., Kivinen, K., Palotie, A., Bochud, P.Y., Boillat, N., Nussle, S.G., Albrich, W., Pagani, J.L., Zu Bentrup, F.M., Viollet, R.M., Kampouri, E.E., Meuwly, J.Y., D'Acremont, V., Younes, S.E., Albrich, W.C., O'Mahony, L., Kleger, G.R., Kahlert, C.R., Negro, T.R., Carreras, A., Galván-Femenía, I., Farré, X., Cortés, B., Mercader, J.M., Guindo-Martinez, M., Torrents, D., Garcia-Aymerich, J., Castaño-Vinyals, G., Dobaño, C., Gori, M., Mondelli, M.U., Castelli, F., Vaghi, M., Rusconi, S., Montagnani, F., Bargagli, E., Franchi, F., Mazzei, M.A., Cantarini, L., Tacconi, D., Feri, M., Scala, R., Spargi, G., Nencioni, C., Bandini, M., Caldarelli, G.P., Spagnesi, M., Canaccini, A., Ognibene, A., D'Arminio Monforte, A., Girardis, M., Antinori, A., Francisci, D., Schiaroli, E., Scotton, P.G., Panese, S., Scaggiante, R., Monica, M.D., Capasso, M., Fiorentino, G., Castori, M., Aucella, F., Di Biagio, A., Masucci, L., Valente, S., Mandalà, M., Zucchi, P., Giannattasio, F., Coviello, D.A., Mussini, C., Bosio, G., Tavecchia, L., Crotti, L., Rizzi, M., La Rovere, M.T., Sarzi-Braga, S., Bussotti, M., Ravaglia, S., Artuso, R., Perrella, A., Romani, D., Bergomi, P., Catena, E., Vincenti, A., Ferri, C., Grassi, D., Pessina, G., Tumbarello, M., Di Pietro, M., Sabrina, R., Luchi, S., Barbieri, C., Acquilini, D., Andreucci, E., Paciosi, F., Segala, F.V., Tiseo, G., Falcone, M., Lista, M., Poscente, M., De Vivo, O., Petrocelli, P., Guarnaccia, A., Baroni, S., Perticaroli, V., Furini, S., Dei, S., Benetti, E., Picchiotti, N., Sanarico, M., Ceri, S., Pinoli, P., Raimondi, F., Biscarini, F., Stella, A., Bergomi, M., Zguro, K., Capitani, K., Tanfoni, M., Fallerini, C., Daga, S., Baldassarri, M., Fava, F., Frullanti, E., Valentino, F., Doddato, G., Giliberti, A., Tita, R., Amitrano, S., Bruttini, M., Croci, S., Meloni, I., Mencarelli, M.A., Lo Rizzo, C., Pinto, A.M., Beligni, G., Tommasi, A., Di Sarno, L., Palmieri, M., Carriero, M.L., Alaverdian, D., Iuso, N., Inchingolo, G., Busani, S., Bruno, R., Vecchia, M., Belli, M.A., Mantovani, S., Ludovisi, S., Quiros-Roldan, E., Antoni, M.D., Zanella, I., Siano, M., Emiliozzi, A., Fabbiani, M., Rossetti, B., Zanelli, G., Bergantini, L., D'Alessandro, M., Cameli, P., Bennet, D., Anedda, F., Marcantonio, S., Scolletta, S., Guerrini, S., Conticini, E., Frediani, B., Spertilli, C., Donati, A., Guidelli, L., Corridi, M., Croci, L., Piacentini, P., Desanctis, E., Cappelli, S., Verzuri, A., Anemoli, V., Pancrazi, A., Lorubbio, M., Merlini, E., Miraglia, F.G., Venturelli, S., Cossarizza, A., Vergori, A., Gabrieli, A., Riva, A., Andretta, F., Gatti, F., Parisi, S.G., Baratti, S., Piscopo, C., Russo, R., Andolfo, I., Iolascon, A., Carella, M., Merla, G., Squeo, G.M., Raggi, P., Marciano, C., Perna, R., Bassetti, M., Sanguinetti, M., Giorli, A., Salerni, L., Parravicini, P., Menatti, E., Trotta, T., Coiro, G., Lena, F., Martinelli, E., Mancarella, S., Gabbi, C., Maggiolo, F., Ripamonti, D., Bachetti, T., Suardi, C., Parati, G., Bottà, G., Di Domenico, P., Rancan, I., Bianchi, F., Colombo, R., van Heel, D.A., Hunt, K.A., Trembath, R.C., Huang, Q.Q., Martin, H.C., Mason, D., Trivedi, B., Wright, J., Finer, S., Griffiths, C.J., Akhtar, S., Anwar, M., Arciero, E., Ashraf, S., Breen, G., Chung, R., Curtis, C.J., Chowdhury, M., Colligan, G., Deloukas, P., Durham, C., Griffiths, C., Hurles, M., Hussain, S., Islam, K., Lavery, C., Lee, S.H., Lerner, R., MacArthur, D., MacLaughlin, B., Martin, H., Miah, S., Newman, B., Safa, N., Tahmasebi, F., Smith, A.V., Boughton, A.P., Li, K.W., LeFaive, J., Annis, A., Jannes, C.E., Krieger, J.E., Pereira, A.C., Velho, M., Marques, E., Lima, I.R., Tada, M.T., Valino, K., McCarthy, M., Rosenberger, C., Lee, J.E., Chang, D., Hammer, C., Hunkapiller, J., Mahajan, A., Pendergrass, S., Sucheston-Campbell, L., Yaspan, B., Lee, H.S., Shin, E., Jang, H.Y., Kym, S., Kim, Y.S., Jeong, H., Kwon, K.T., Kim, S.W., Kim, J.Y., Jang, Y.R., Kim, H.A., Lee, J.Y., Choe, K.W., Kang, Y.M., Jee, S.H., Jung, K.J., Parikh, V., Ashley, E., Wheeler, M., Rivas, M., Bustamante, C., Pinksy, B., Febbo, P., Farh, K., Schroth, G.P., deSouza, F., Dalton, K., Christle, J., Deboever, C., Szalma, S., Rubinacci, S., Delaneau, O., Gorzynski, J., de Jong, H., Sutton, S., Youlton, N., Joshi, R., Jimenez-Morales, D., Hughes, C., Amar, D., Ioannidis, A., Hershman, S., Kirillova, A., Seo, K., Huang, Y., Shoura, M., Hammond, N., Watson, N., Raja, A., Huang, C., Sahoo, M., Wang, H., Zhen, J., Rakitko, A., Ilinsky, V., Yermakovich, D., Popov, I., Chernitsov, A., Kovalenko, E., Krasnenko, A., Plotnikov, N., Stetsenko, I., Kim, A., Cirulli, E.T., Schiabor Barrett, K.M., Bolze, A., White, S., Washington, N.L., Lu, J.T., Riffle, S., Tanudjaja, F., Ramirez, J.M., Leonetti, N., Neveux, I., Dabe, S., Grzymski, J.J., Esteban Miñano, J.I., Aguirre, L.A., López-Collazo, E., de la Mata Pazos, M., Cerrato, L., Lozano-Rodríguez, R., Avendaño-Ortiz, J., Arcos, V.T., Montalbán-Hernández, K.M., Quiroga, J.V., Pascual-Iglesias, A., Maroun-Eid, C., Martín-Quirós, A., Namkoong, H., Imoto, S., Katayama, K., Fukunaga, K., Kitagawa, Y., Sato, T., Hasegawa, N., Kumanogoh, A., Kimura, A., Ai, M., Tokunaga, K., Kanai, T., Miyano, S., Ogawa, S., Edahiro, R., Sonehara, K., Shirai, Y., Ishii, M., Kabata, H., Masaki, K., Kamata, H., Ikemura, S., Chubachi, S., Okamori, S., Terai, H., Tanaka, H., Morita, A., Lee, H., Asakura, T., Sasaki, J., Morisaki, H., Uwamino, Y., Nanki, K., Mikami, Y., Tomono, K., Kato, K., Matsuda, F., Takahashi, M., Hizawa, N., Takeda, Y., Hirata, H., Shiroyama, T., Miyawaki, S., Suzuki, K., Maeda, Y., Nii, T., Noda, Y., Niitsu, T., Adachi, Y., Enomoto, T., Amiya, S., Hara, R., Takahashi, K., Anzai, T., Hasegawa, T., Ito, S., Koike, R., Endo, A., Uchimura, Y., Miyazaki, Y., Honda, T., Tateishi, T., Tohda, S., Ichimura, N., Sonobe, K., Sassa, C., Nakajima, J., Nannya, Y., Omae, Y., Harada, N., Hiki, M., Takagi, H., Nakamura, A., Tagaya, E., Kawana, M., Arimura, K., Ishiguro, T., Takayanagi, N., Isono, T., Takaku, Y., Takano, K., Anan, R., Nakajima, Y., Nakano, Y., Nishio, K., Ueda, S., Hayashi, R., Tateno, H., Hase, I., Yoshida, S., Suzuki, S., Mitamura, K., Saito, F., Ueda, T., Azuma, M., Nagasaki, T., Yasui, Y., Hasegawa, Y., Mutoh, Y., Yoshiyama, T., Shoko, T., Kojima, M., Adachi, T., Ishikawa, M., Watanabe, K., Manabe, T., Ito, F., Fukui, T., Funatsu, Y., Koh, H., Hirai, Y., Kawashima, H., Narita, A., Niwa, K., Sekikawa, Y., Yoshiya, K., Yoshihara, T., Suzuki, Y., Nakayama, S., Masuzawa, K., Nishi, K., Nishitsuji, M., Tani, M., Inoue, T., Hirano, T., Kobayashi, K., Miyazawa, N., Kimura, Y., Sado, R., Ogura, T., Kitamura, H., Murohashi, K., Nakachi, I., Baba, R., Arai, D., Fuke, S., Saito, H., Kuwahara, N., Fujiwara, A., Okada, T., Baba, T., Noda, J., Mashimo, S., Yagi, K., Shiomi, T., Hashiguchi, M., Odani, T., Mochimaru, T., Oyamada, Y., Mori, N., Izumi, N., Nagata, K., Taki, R., Murakami, K., Yamada, M., Sugiura, H., Hayashi, K., Shimizu, T., Gon, Y., Fujitani, S., Tsuchida, T., Yoshida, T., Kagaya, T., Kita, T., Sakagami, S., Kimizuka, Y., Kawana, A., Nakamura, Y., Ishikura, H., Takata, T., Kikuchi, T., Taniyama, D., Nakamura, M., Kodama, N., Kaneyama, Y., Maeda, S., Nagasaki, Y., Okamoto, M., Ishihara, S., Ito, A., Chihara, Y., Takeuchi, M., Onoi, K., Hashimoto, N., Wakahara, K., Ando, A., Masuda, M., Wakabayashi, A., Watanabe, H., Sageshima, H., Nakada, T.A., Abe, R., Shimada, T., Kawamura, K., Ichikado, K., Nishiyama, K., Yamasaki, M., Hashimoto, S., Kusaka, Y., Ohba, T., Isogai, S., Takada, M., Kanda, H., Komase, Y., Sano, F., Asano, K., Oguma, T., Harada, M., Takahashi, T., Shibusawa, T., Abe, S., Kono, Y., Togashi, Y., Izumo, T., Inomata, M., Awano, N., Ogata, T., Kanehiro, A., Ozaki, S., Fuchimoto, Y., Ogura, S., Yoshida, K., Beppu, S., Fukuyama, S., Eriguchi, Y., Yonekawa, A., Inoue, Y., Yamagata, K., Chiba, S., Narumoto, O., Nagai, H., Ooshima, N., Motegi, M., Sagara, H., Tanaka, A., Ohta, S., Shibata, Y., Tanino, Y., Sato, Y., Yamada, Y., Hashino, T., Shinoki, M., Iwagoe, H., Imamura, T., Umeda, A., Shimada, H., Endo, M., Hayashi, S., Nakano, S., Yatomi, M., Maeno, T., Ishii, T., Utsugi, M., Ono, A., Kanaoka, K., Ihara, S., Komuta, K., Boezen, M., Claringbould, A., Lopera, E., Warmerdam, R., Vonk, J.M., van Blokland, I., Lanting, P., Ori, APS, Obeidat, M., Hernández Cordero, A.I., Sin, D.D., Bossé, Y., Joubert, P., Hao, K., Nickle, D., Timens, W., van den Berge, M., Feng, Y.A., Mercader, J., Weiss, S.T., Karlson, E.W., Smoller, J.W., Murphy, S.N., Meigs, J.B., Woolley, A.E., Green, R.C., Perez, E.F., Zöllner, S., Wang, J., Beck, A., Sloofman, L.G., Ascolillo, S., Sebra, R.P., Collins, B.L., Levy, T., Sealfon, S.C., Jordan, D.M., Thompson, R.C., Gettler, K., Chaudhary, K., Belbin, G.M., Preuss, M., Hoggart, C., Choi, S., Underwood, S.J., Salib, I., Britvan, B., Keller, K., Tang, L., Peruggia, M., Hiester, L.L., Niblo, K., Aksentijevich, A., Labkowsky, A., Karp, A., Zlatopolsky, M., Zyndorf, M., Charney, A.W., Beckmann, N.D., Schadt, E.E., Abul-Husn, N.S., Cho, J.H., Itan, Y., Kenny, E.E., Loos, RJF, Nadkarni, G.N., Do, R., O'Reilly, P., Huckins, L.M., Ferreira, MAR, Abecasis, G.R., Leader, J.B., Cantor, M.N., Justice, A.E., Carey, D.J., Chittoor, G., Josyula, N.S., Kosmicki, J.A., Horowitz, J.E., Baras, A., Gass, M.C., Yadav, A., Mirshahi, T., Jan Hottenga, J., Bartels, M., de Geus, EJC, Nivard, M.G., Verma, A., Ritchie, M.D., Rader, D., Li, B., Verma, S.S., Lucas, A., Bradford, Y., Zara, F., Salpietro, V., Scala, M., Iacomino, M., Scudieri, P., Bocciardi, R., Minetti, C., Vari, M.S., Rahier, J.F., Giorgio, E., Carli, D., Louis, E., Bulik, C.M., Landén, M., Brusco, A., Ferrero, G.B., Madia, F., Fundín, B., Ismail, S.I., Saad, C., Al-Sarraj, Y., Badji, R.M., Al-Muftah, W., Al Thani, A., Afifi, N., Klovins, J., Rovite, V., Rescenko, R., Peculis, R., Ustinova, M., Zeberg, H., Frithiof, R., Hultström, M., Lipcsey, M., Johnson, R., Geschwind, D.H., Freimer, N., Butte, M.J., Ding, Y., Chiu, A., Chang, T.S., Boutros, P., Moutsianas, L., Caulfield, M.J., Scott, R.H., Walker, S., Stuckey, A., Odhams, C.A., Rhodes, D., Fowler, T., Rendon, A., Chan, G., Arumugam, P., Karczewski, K.J., Wilson, D.J., Spencer, C.A., Crook, D.W., Wyllie, D.H., O'Connell, A.M., Atkinson, E.G., Tsuo, K., Baya, N., Turley, P., Gupta, R., Walters, R.K., Palmer, D.S., Sarma, G., Cheng, N., Lu, W., Churchhouse, C., Goldstein, J.I., King, D., Seed, C., Daly, M.J., Bryant, S., Satterstrom, F.K., Band, G., Earle, S.G., Lin, S.K., Arning, N., Armstrong, J., Rudkin, J.K., Callier, S., Cusick, C., Soranzo, N., Zhao, J.H., Danesh, J., Di Angelantonio, E., Butterworth, A.S., Sun, Y.V., Huffman, J.E., Cho, K., O'Donnell, C.J., Tsao, P., Gaziano, J.M., Peloso, G., Ho, Y.L., Mian, M., Scaggiante, F., Chang, X., Glessner, J.R., Hakonarson, H., McGuigan, P.J., Prockter Moore, L.S., Vizcaychipi, M.P., Hall, K., Campbell, A., Nichol, A., Ward, G., Page, V.J., Semple, M.G., Adeniji, K., Agranoff, D., Agwuh, K., Ail, D., Aldera, E.L., Alegria, A., Angus, B., Ashish, A., Atkinson, D., Bari, S., Barlow, G., Barnass, S., Barrett, N., Bassford, C., Basude, S., Baxter, D., Beadsworth, M., Bernatoniene, J., Berridge, J., Best, N., Bothma, P., Chadwick, D., Brittain-Long, R., Bulteel, N., Burden, T., Burtenshaw, A., Caruth, V., Chambler, D., Chee, N., Child, J., Chukkambotla, S., Clark, T., Collini, P., Cosgrove, C., Cupitt, J., Cutino-Moguel, M.T., Dark, P., Dawson, C., Dervisevic, S., Donnison, P., Douthwaite, S., Drummond, A., DuRand, I., Dushianthan, A., Dyer, T., Evans, C., Eziefula, C., Fegan, C., Finn, A., Fullerton, D., Garg, S., Garg, A., Gkrania-Klotsas, E., Godden, J., Goldsmith, A., Graham, C., Hardy, E., Hartshorn, S., Harvey, D., Havalda, P., Hawcutt, D.B., Hobrok, M., Hodgson, L., Hormis, A., Jacobs, M., Jain, S., Jennings, P., Kaliappan, A., Kasipandian, V., Kegg, S., Kelsey, M., Kendall, J., Kerrison, C., Kerslake, I., Koch, O., Koduri, G., Koshy, G., Laha, S., Laird, S., Larkin, S., Leiner, T., Lillie, P., Limb, J., Linnett, V., Little, J., Lyttle, M., MacMahon, M., MacNaughton, E., Mankregod, R., Masson, H., Matovu, E., McCullough, K., McEwen, R., Meda, M., Mills, G.H., Minton, J., Ward, K., Mirfenderesky, M., Mohandas, K., Mok, Q., Moon, J., Moore, E., Morgan, P., Morris, C., Mortimore, K., Moses, S., Mpenge, M., Mulla, R., Murphy, M., Nagel, M., Nagarajan, T., Nelson, M., O'Shea, M.K., Otahal, I., Ostermann, M., Pais, M., Panchatsharam, S., Papakonstantinou, D., Paraiso, H., Patel, B., Pattison, N., Pepperell, J., Peters, M., Phull, M., Pintus, S., Pooni, J.S., Post, F., Price, D., Prout, R., Rae, N., Reschreiter, H., Reynolds, T., Richardson, N., Roberts, M., Roberts, D., Rose, A., Rousseau, G., Ryan, B., Saluja, T., Shah, A., Shanmuga, P., Sharma, A., Shawcross, A., Sizer, J., Shankar-Hari, M., Smith, R., Snelson, C., Spittle, N., Staines, N., Stambach, T., Stewart, R., Subudhi, P., Szakmany, T., Tatham, K., Thomas, J., Thompson, C., Thompson, R., Tridente, A., Tupper-Carey, D., Twagira, M., Ustianowski, A., Vallotton, N., Vincent-Smith, L., Visuvanathan, S., Vuylsteke, A., Waddy, S., Wake, R., Walden, A., Welters, I., Whitehouse, T., Whittaker, P., Whittington, A., Papineni, P., Wijesinghe, M., Williams, M., Wilson, L., Cole, S., Winchester, S., Wiselka, M., Wolverson, A., Wooton, D.G., Workman, A., Yates, B., Young, P., Beale, R., Bretherick, A.D., Clohisey, S., Fourman, M.H., Furniss, J., Gountouna, E., Grimes, G., Haley, C., Harrison, D., Hayward, C., Keating, S., Klaric, L., Klenerman, P., Law, A., Meynert, A.M., Millar, J., Pairo-Castineira, E., Parkinson, N., Ponting, C.P., Porteous, D.J., Rawlik, K., Richmond, A., Rowan, K., Russell, C.D., Shen, X., Shih, B., Tenesa, A., Vitart, V., Wang, B., Wilson, J.F., Wu, Y., Yang, J., Yang, Z., Zechner, M., Zhai, R., Zheng, C., Norman, L., Pius, R., Drake, T.M., Fairfield, C.J., Knight, S.R., Mclean, K.A., Murphy, D., Shaw, C.A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Jackson, C., Gamble, C., Leeming, G., Wham, M., Hendry, R., Scott-Brown, J., Begg, C., Hinds, C., Wai Ho, A.Y., Horby, P.W., Knight, J., Ling, L., Maslove, D., McAuley, D., Montgomery, H., Openshaw, PJM, Summers, C., Walsh, T., Armstrong, L., Bates, H., Dooks, E., Farquhar, F., Hairsine, B., McParland, C., Packham, S., Alldis, Z., Astin-Chamberlain, R., Bibi, F., Biddle, J., Blow, S., Bolton, M., Borra, C., Bowles, R., Burton, M., Choudhury, Y., Collier, D., Cox, A., Easthope, A., Ebano, P., Fotiadis, S., Gurasashvili, J., Halls, R., Hartridge, P., Kallon, D., Kassam, J., Lancoma-Malcolm, I., Matharu, M., May, P., Mitchelmore, O., Newman, T., Patel, M., Pheby, J., Pinzuti, I., Prime, Z., Prysyazhna, O., Shiel, J., Taylor, M., Tierney, C., Wood, S., Zak, A., Zongo, O., Forsey, M., Nicholson, A., Riches, J., Vertue, M., Wasson, C., Finn, S., Green, J., Collins, E., King, B., Grauslyte, L., Hussain, M., Pogreban, T., Rosaroso, L., Salciute, E., Franke, G., Wong, J., George, A., Akeroyd, L., Bano, S., Bromley, M., Gurr, L., Lawton, T., Morgan, J., Sellick, K., Warren, D., Wilkinson, B., McGowan, J., Ledgard, C., Stacey, A., Pye, K., Bellwood, R., Bentley, M., Loosley, R., McGuinness, H., Tench, H., Wolf-Roberts, R., Gibson, S., Lyle, A., McNeela, F., Radhakrishnan, J., Hughes, A., Ali, A., Brady, M., Dale, S., Dance, A., Gledhill, L., Greig, J., Hanson, K., Holdroyd, K., Home, M., Kelly, D., Kitson, R., Matapure, L., Melia, D., Mellor, S., Nortcliffe, T., Pinnell, J., Robinson, M., Shaw, L., Shaw, R., Thomis, L., Wilson, A., Wood, T., Bayo, L.A., Merwaha, E., Ishaq, T., Hanley, S., Antcliffe, D., Banach, D., Brett, S., Coghlan, P., Fernandez, Z., Gordon, A., Rojo, R., Arias, S.S., Templeton, M., Jha, R., Krishnamurthy, V., Lim, L., Bi, R., Scholefield, B., Ashton, L., Williams, A., Cheyne, C., Saunderson, A., Allan, A., Anderson, F., Kaye, C., Liew, J., Medhora, J., Scott, T., Trumper, E., Botello, A., Polgarova, P., Stroud, K., Meaney, E., Jones, M., Ng, A., Agrawal, S., Pathan, N., White, D., Daubney, E., Elston, K., Parker, R., Reddy, A., Turner-Bone, I., Wilding, L., Harding, P., Jacob, R., Jones, C., Denmade, C., Croft, M., White, I., Griffin, D., Muchenje, N., Mupudzi, M., Partridge, R., Conyngham, J.A., Thomas, R., Wright, M., Corral, M.A., Bastion, V., Clarke, D., David, B., Kent, H., Lorusso, R., Lubimbi, G., Murdoch, S., Penacerrada, M., Thomas, A., Valentine, J., Vochin, A., Wulandari, R., Djeugam, B., Dawson, J., Garrioch, S., Tolson, M., Aldridge, J., de Almeida Martins, L.G., Carungcong, J., Beavis, S., Dale, K., Gascoyne, R., Hawes, J., Pritchard, K., Stevenson, L., Whileman, A., Cowley, A., Highgate, J., Crawley, R., Crew, A., Cunningham, M., Daniels, A., Harrison, L., Hope, S., Inweregbu, K., Jones, S., Lancaster, N., Matthews, J., Wray, G., Benham, L., Bradshaw, Z., Brown, J., Caswell, M., Melling, S., Preston, S., Slawson, N., Stoddard, E., Warden, S., Combes, E., Joefield, T., Monnery, S., Beech, V., Trotman, S., Hopkins, B., Scriven, J., Thrasyvoulou, L., Willis, H., Anderson, S., Birch, J., Hammerton, K., O'Leary, R., Abernathy, C., Foster, L., Gratrix, A., Martinson, V., Parkinson, P., Stones, E., Carbral-Ortega, L., Kapoor, R., Loader, D., Castle, K., Brandwood, C., Smith, L., Clark, R., Birchall, K., Kolakaluri, L., Baines, D., Sukumaran, A., Mapfunde, I., Meredith, M., Morris, L., Ryan, L., Clark, A., Sampson, J., Peters, C., Dent, M., Langley, M., Wei, S., Andrew, A., Chablani, M., Kirkby, A., Netherton, K., Bates, M., Dasgin, J., Gill, J., Nilsson, A., Apetri, E., Basikolo, C., Blackledge, B., Catlow, L., Charles, B., Doonan, R., Harris, J., Harvey, A., Horner, D., Knowles, K., Lomas, D., Lyons, C., Marsden, T., McLaughlan, D., McMorrow, L., Pendlebury, J., Perez, J., Poulaka, M., Proudfoot, N., Slaughter, M., Slevin, K., Thomas, V., Walker, D., Michael, A., Collis, M., Clark, M., Coulding, M., Jude, E., McCormick, J., Mercer, O., Potla, D., Rehman, H., Savill, H., Turner, V., Davey, M., Golden, D., Seaman, R., Hunt, J., Dearden, J., Dobson, E., Mulcahy, M., Munt, S., O'Connor, G., Philbin, J., Rishton, C., Tully, R., Winnard, S., Cagova, L., Fofano, A., Garner, L., Holcombe, H., Mepham, S., Mitchell, A.M., Mwaura, L., Zamikula, J., Bercades, G., Brealey, D., Hass, I., MacCallum, N., Martir, G., Raith, E., Reyes, A., Smyth, D., Taylor, A., Hughes, R.A., Thomas, H., Rees, A., Duskova, M., Phipps, J., Brooks, S., Edwards, M., Alexander, P., Allen, S., Bradley-Potts, J., Brantwood, C., Egan, J., Felton, T., Padden, G., Ward, L., Moss, S., Glasgow, S., Beesley, K., Board, S., Kubisz-Pudelko, A., Lewis, A., Perry, J., Pippard, L., Wood, D., Buckley, C., Brown, A., Gregory, J., O'Connell, S., Smith, T., Belagodu, Z., Fuller, B., Gherman, A., Olufuwa, O., Paramsothy, R., Stuart, C., Oakley, N., Kamundi, C., Tyl, D., Collins, K., Silva, P., Taylor, J., King, L., Coates, C., Crowley, M., Wakefield, P., Beadle, J., Johnson, L., Sargeant, J., Anderson, M., Jardine, C., Williams, D., Parris, V., Quaid, S., Watson, E., Melville, J., Naisbitt, J., Joseph, R., Lazo, M., Walton, O., Neal, A., Hill, M., Kannan, T., Wild, L., Allan, E., Darlington, K., Davies, F., Easton, J., Kumar, S., Lean, R., Menzies, D., Pugh, R., Qiu, X., Davies, L., Williams, H., Scanlon, J., Davies, G., Mackay, C., Lewis, J., Rees, S., Coetzee, S., Gales, A., Raj, M., Sell, C., Langton, H., Watters, M., Novis, C., Arbane, G., Bociek, A., Campos, S., Grau, N., Jones, T.O., Lim, R., Marotti, M., Whitton, C., Barron, A., Collins, C., Kaul, S., Passmore, H., Prendergast, C., Reed, A., Rogers, P., Shokkar, R., Woodruff, M., Middleton, H., Polgar, O., Nolan, C., Thwaites, V., Mahay, K., Sri-Chandana, C., Scherewode, J., Stephenson, L., Marsh, S., Bancroft, H., Bellamy, M., Carmody, M., Daglish, J., Moore, F., Rhodes, J., Sangombe, M., Kadiri, S., Ayers, A., Harrison, W., North, J., Cavazza, A., Cockrell, M., Corcoran, E., Depante, M., Finney, C., Jerome, E., McPhail, M., Nayak, M., Noble, H., O'Reilly, K., Pappa, E., Saha, R., Saha, S., Smith, J., Knighton, A., Gill, M., Paul, P., Ratnam, V., Shelton, S., Wynter, I., Baptista, D., Crowe, R., Fernandes, R., Herdman-Grant, R., Joseph, A., Loveridge, A., McKenley, I., Morino, E., Naranjo, A., Simms, R., Sollesta, K., Swain, A., Venkatesh, H., Khera, J., Fox, J., Barber, R., Hewitt, C., Hilldrith, A., Jackson-Lawrence, K., Shepardson, S., Wills, M., Butler, S., Tavares, S., Cunningham, A., Hindale, J., Arif, S., George, L., Twiss, S., Wright, D., Holland, M., Keenan, N., Lyons, M., Wassall, H., Marsh, C., Mahenthran, M., Carter, E., Kong, T., Adanini, O., Bhatia, N., Msiska, M., Mew, L., Mwaura, E., Williams, F., Wren, L., Sutherland, S.B., Battle, C., Brinkworth, E., Harford, R., Murphy, C., Newey, L., Rees, T., Arnold, S., Hardy, J., Houlden, H., Moncur, E., Tariq, A., Tucci, A., Convery, K., Fottrell-Gould, D., Hudig, L., Keshet-Price, J., Randell, G., Stammers, K., Abdelrazik, M., Bakthavatsalam, D., Elhassan, M., Ganesan, A., Haldeos, A., Moreno-Cuesta, J., Purohit, D., Vincent, R., Xavier, K., Rohit, K., Alasdair, F., Saleem, M., David, C., Jenkins, S., Lamond, Z., Wall, A., Reynolds, J., Campbell, H., Thompsom, M., Dodds, S., Duffy, S., Butcher, D., O'Sullivan, S., Butterworth-Cowin, N., Deacon, B., Hibbert, M., Pothecary, C., Tetla, D., Woodford, C., Durga, L., Kennard-Holden, G., de Gordoa, L.O., Peasgood, E., Phillips, C., Skinner, D., Gaylard, J., Mullan, D., Newman, J., Davies, E., Roche, L., Sathe, S., Brimfield, L., Daly, Z., Pogson, D., Rose, S., Collins, A., Khaliq, W., Gude, E.T., Allen, L., Beranova, E., Crisp, N., Deery, J., Hazelton, T., Knight, A., Price, C., Tilbey, S., Turki, S., Turney, S., Giles, J., Booth, S., Bell, G., English, K., Katary, A., Wilcox, L., Campbell, R., Clarke, N., Whiteside, J., Mascarenhas, M., Donaldson, A., Matheson, J., Barrett, F., O'Hara, M., O'Keefe, L., Bradley, C., Walker, R., Maynard, V., Patel, T., Smith, M., Kazi, A., Hartley, J., Dykes, J., Hijazi, M., Keith, S., Khan, M., Ryan-Smith, J., Springle, P., Truman, N., Saad, S., Coleman, D., Fine, C., Matt, R., Gay, B., Dalziel, J., Ali, S., Goodchild, D., Harling, R., Bhatterjee, R., Goddard, W., Davison, C., Duberly, S., Hargreaves, J., Bolton, R., Verlander, M., Blackman, H., Creagh-Brown, B., Donlon, S., Michalak-Glinska, N., Mtuwa, S., Pristopan, V., Salberg, A., Smith, E., Stone, S., Piercy, C., Verula, J., Burda, D., Montaser, R., Harden, L., Mayangao, I., Marriott, C., Bradley, P., Harris, C., Cooper, J., Finch, C., Liderth, S., Quinn, A., Waddington, N., Fidler, K., Tagliavini, E., Donnelly, K., Abel, L., Brett, M., Digby, B., Gemmell, L., Hornsby, J., MacGoey, P., O'Neil, P., Price, R., Rodden, N., Rooney, K., Sundaram, R., Thomson, N., Flanagan, R., Hughes, G., Latham, S., McKenna, E., Anderson, J., Hull, R., Rhead, K., Branney, D., Frankham, J., Pitts, S., White, N., Cristiano, D., Dormand, N., Farzad, Z., Gummadi, M., Liyanage, K., Patel, B.V., Salmi, S., Sloane, G., Varghese, M., Zborowski, A.C., Bean, S., Burt, K., Spivey, M., Eastgate-Jackson, C., Filipe, H., Martin, D., Maharajh, A., Garcia, S.M., De Neef, M., Lynch, C., Howe, G.S., Singh, J., Turner, K., Ellis, H., Stroud, N., Cherian, S., Cutler, S., Heron, A.E., Roynon-Reed, A., Williams, G., Richards, O., Cheema, Y., Ahmad, N., Barker, J., Bauchmuller, K., Bird, S., Cawthron, K., Harrington, K., Jackson, Y., Kibutu, F., Lenagh, B., Masuko, S., Raithatha, A., Wiles, M., Willson, J., Newell, H., Lye, A., Nwafor, L., Jarman, C., Rowland-Jones, S., Foote, D., Cole, J., Watson, J., Hesseldon, L., Macharia, I., Chetam, L., Ford, A., Housley, K., Milner, L., Hanratty, H., Trower, H., Phillips, P., Oxspring, S., Donne, B., Bevan, E., Martin, J., Trodd, D., Watson, G., Brown, C.W., Bunni, L., Jennings, C., Latif, M., Marshall, R., Subramanian, G., Bandla, N., Gellamucho, M., Davies, M., Trim, F., Eapen, B., Ahmed, C., Baines, B., Clamp, S., Colley, J., Haq, R., Hayes, A., Hulme, J., Joseph, S., Kumar, R., Maqsood, Z., Purewal, M., Chandler, B., Elliott, K., Mallinson, J., Turnbull, A., Dent, K., Horsley, E., Akhtar, M.N., Pearson, S., Potoczna, D., Spencer, S., Blakemore, H., Borislavova, B., Faulkner, B., Gendall, E., Goff, E., Hayes, K., Thomas, M., Worner, R., Smith, K., Stephens, D., Delgado, C.C., Dawson, D., Ding, L., Durrant, G., Ezeobu, O., Farnell-Ward, S., Harrison, A., Kanu, R., Leaver, S., Maccacari, E., Manna, S., Saluzzio, R.P., Queiroz, J., Samakomva, T., Sicat, C., Texeira, J., Da Gloria, E.F., Lisboa, A., Rawlins, J., Mathew, J., Kinch, A., Hurt, W.J., Shah, N., Clark, V., Thanasi, M., Yun, N., Patel, K., Crickmore, V., Debreceni, G., Wilkins, J., Nicol, L., Burn, I., Hambrook, G., Manso, K., Penn, R., Shanmugasundaram, P., Tebbutt, J., Thornton, D., Rostron, A., Roy, A., Woods, L., Cornell, S., Wakinshaw, F., Rogerson, K., Jarmain, J., Anderson, P., Archer, K., Austin, K., Davis, C., Durie, A., Kelsall, O., Thrush, J., Vigurs, C., Wood, H.L., Tranter, H., Cowley, N., McAlindon, M., Digby, S., Low, E., Morgan, A., Cother, N., Rankin, T., Clayton, S., McCurdy, A., Allibone, S., Mary-Genetu, R., Patel, A., Mac, A., Murphy, A., Mahjoob, P., Nazari, R., Worsley, L., Fagan, A., Mohamed Ali, I.A., Beaumont, K., Blunt, M., Coton, Z., Curgenven, H., Elsaadany, M., Fernandes, K., Ally, S.M., Rangarajan, H., Sarathy, V., Selvanayagam, S., Vedage, D., White, M., Fernandez-Roman, J., Hamilton, D.O., Johnson, E., Johnston, B., Martinez, M.L., Mulla, S., Shaw, D., Waite, AAC, Waugh, V., Welters, I.D., Williams, K., Bemand, T., Black, E., Rosa, A.D., Howle, R., Jhanji, S., Baikady, R.R., Tatham, K.C., Thomas, B., Halkes, M., Mercer, P., Thornton, L., West, J., Baird, T., Ruddy, J., Reece-Anthony, R., Birt, M., Cowton, A., Kay, A., Kent, M., Potts, K., Wilkinson, A., Naylor, S., Brown, E., Purvis, S., Davies, R., Duffin, D., Hill, H., Player, B., Thomas, E., Beith, C.M., Black, K., Clements, S., Morrison, A., Strachan, D., Clarkson, M., D'Sylva, S., Norman, K., Coventry, T., Fowler, S., McGregor, A., Brady, A., Chan, R., McIvor, S., Prady, H., Whittle, H., Mathew, B., Clapham, M., Harper, R., Poultney, U., Rice, P., Mutch, R., Baird, Y., Butler, A., Chadbourn, I., Folkes, L., Fox, H., Gardner, A., Gomez, R., Hobden, G., King, K., Margarson, M., Martindale, T., Meadows, E., Raynard, D., Thirlwall, Y., Helm, D., Margalef, J., Greer, S., Shuker, K., Smuts, S., Duffield, J., Smith, O., Mallon, L., Claire, W., Birkinshaw, I., Carter, J., Howard, K., Ingham, J., Joy, R., Pearson, H., Roche, S., Scott, Z., Knights, E., Price, A., Thorpe, C., Abraheem, A., Bamford, P., Cawley, K., Dunmore, C., Faulkner, M., Girach, R., Jeffrey, H., Jones, R., London, E., Nagra, I., Nasir, F., Sainsbury, H., Smedley, C., Khade, R., Sundar, A., Tsinaslanidis, G., Behan, T., Burnett, C., Hatton, J., Heeney, E., Mitra, A., Newton, M., Pollard, R., Stead, R., Bough, L., Goodsell, J., Tutton, R., Williams, P., Williams, S., Winter-Goodwin, B., Auld, F., Donnachie, J., Edmond, I., Prentice, L., Runciman, N., Salutous, D., Symon, L., Todd, A., Turner, P., Short, A., Sweeney, L., Murdoch, E., Senaratne, D., Burns, K., Higham, A., Anderson, T., Hawcutt, D., O'Malley, L., Rad, L., Rogers, N., Saunderson, P., Allison, K.S., Afolabi, D., Whitbread, J., Jones, D., Dore, R., Lankester, L., Nikitas, N., Wells, C., Stowe, B., Spencer, K., Cathcart, S., Duffy, K., Puxty, A., Puxty, K., Turner, L., Ireland, J., Semple, G., Barry, P., Hilltout, P., Evitts, J., Tyler, A., Waldron, J., Irvine, V., Shelley, B., Akinkugbe, O., Bamford, A., Beech, E., Belfield, H., Bell, M., Davies, C., Jones, GAL, McHugh, T., Meghari, H., O'Neill, L., Peters, M.J., Ray, S., Tomas, A.L., Gorman, C., Gupta, A., Timlick, E., Brady, R., Bonner, S., Hugill, K., Jones, J., Liggett, S., Bashyal, A., Davidson, N., Hutton, P., McKechnie, S., Wilson, J., Flint, N., Rekha, P., Hales, D., Cruz, C., Gopal, S., Harris, N., Lake, V., Metherell, S., Radford, E., Clement, I., Hays, C., Hudson, A., Webster, A., Stephenson, E., McCormack, L., Slater, V., Nixon, R., Hanson, H., Fearby, M., Kelly, S., Bridgett, V., Robinson, P., Almaden-Boyle, C., Austin, P., Cabrelli, L., Casey, M., Chapman, S., Whyte, C., Brayne, A., Fisher, E., Jackson, P., Kaye, D., Love, N., Parkin, J., Tuckey, V., van Koutrik, L., Carter, S., Andrew, B., Findlay, L., Adams, K., Bruce, M., Connolly, K., Duncan, T., T-Michael, H., Lindergard, G., Hey, S., Fox, C., Alfonso, J., Durrans, L.J., Guerin, J., Hruska, M., Eltayeb, A., Lamb, T., Hodgkiss, T., Cooper, L., Rothwell, J., Dennis, C., Srikaran, S., Sukha, A., Davies, K., O'Brien, L., Omar, Z., Perkins, E., Lewis, T., Sutherland, I., Brooke, H., Buckley, S., Suarez, J.C., Charlesworth, R., Hansson, K., Norris, J., Poole, A., Sandhu, R., Sloan, B., Smithson, E., Thirumaran, M., Wagstaff, V., Metcalfe, A., Camsooksai, J., Humphrey, C., Wadams, B., DeAth, Y., Adams, C., Agasou, A., Arden, T., Bowes, A., Boyle, P., Beekes, M., Button, H., Capps, N., Carnahan, M., Carter, A., Childs, D., Donaldson, D., Hard, K., Hurford, F., Hussain, Y., Javaid, A., Jose, S., Leigh, M., Martin, T., Millward, H., Motherwell, N., Rikunenko, R., Stickley, J., Summers, J., Ting, L., Tivenan, H., Tonks, L., Wilcox, R., Bokhari, M., Lucas, R., McCormick, W., Ritzema, J., Sanderson, A., Wild, H., Baxter, N., Henderson, S., Kennedy-Hay, S., Rooney, L., Sim, M., McCreath, G., Brunton, M., Caterson, J., Coles, H., Frise, M., Rai, S.G., Keating, L., Tilney, E., Bartley, S., Bhuie, P., Downes, C., Holding, K., Riches, K., Hilton, M., Hayman, M., Subramanian, D., Daniel, P., Zitter, L., Benyon, S., Marriott, S., Park, L., Keenan, S., Gordon, E., Quinn, H., Baines, K., Andrew, G., Barclay, L., Callaghan, M., Clark, S., Hope, D., Marshall, L., McCulloch, C., Briton, K., Singleton, J., Birch, S., Simpson, K., Craig, J., Demetriou, C., Eckbad, C., Hierons, S., Howie, L., Mitchard, S., Ramos, L., Serrano-Ruiz, A., White, K., Kelly, F., Amin, V., Anastasescu, E., Anumakonda, V., Karthik, K., Kausar, R., Reid, K., Imeson-Wood, J., Bellini, A., Bryant, J., Pickard, A., Roe, N., Sowter, J., Howlett, A., Criste, K., Cusack, R., Golder, K., Golding, H., Jones, O., Leggett, S., Male, M., Marani, M., Prager, K., Williams, T., Roberts, B., Salmon, K., Gondo, P., Kayani, A., Masunda, B., Ahmed, A., Morris, A., Jakkula, S., Long, K., Whiteley, S., Wilby, E., Ogg, B., Moultrie, S., Bewley, J., Garland, Z., Grimmer, L., Gumbrill, B., Sweet, K., Webster, D., Efford, G., Bennett, S., Goodwin, E., Jackson, M., Kent, A., Tibke, C., Woodyatt, W., Zaki, A., Daniel, A., Finn, J., Bremmer, P., Houston, G., O'Brien, P., Bell, D., Boyle, R., Douglas, K., Glass, L., Lee, E., Lennon, L., Rattray, A., Charnock, R., McFarland, D., Cosgrove, D., Attwood, B., Parsons, P., Carmody, S., Oblak, M., Popescu, M., Thankachen, M., Baruah, R., Morris, S., Ferguson, S., Shepherd, A., Altabaibeh, A., Alvaro, A., Gilbert, K., Ma, L., Mostoles, L., Parmar, C., Jetha, C., Booker, L., Pratley, A., Cosier, T., Millen, G., Schumacher, N., Weston, H., Rand, J., Alex, B., Bach, B., Barclay, W.S., Bogaert, D., Chand, M., Cooke, G.S., Docherty, A.B., Dunning, J., da Silva Filipe, A., Fletcher, T., Green, C.A., Harrison, E.M., Hiscox, J.A., Ijaz, S., Khoo, S., Lim, W.S., Mentzer, A.J., Merson, L., Noursadeghi, M., Moore, S.C., Palmarini, M., Paxton, W.A., Pollakis, G., Price, N., Rambaut, A., Robertson, D.L., Sancho-Shimizu, V., Scott, J.T., de Silva, T., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Tedder, R.S., Thomson, E.C., Roger Thompson, A.A., Thwaites, R.S., Turtle, LCW, Gupta, R.K., Palmieri, C., Swann, O.V., Zambon, M., Dumas, M.E., Griffin, J.L., Takats, Z., Chechi, K., Andrikopoulos, P., Osagie, A., Olanipekun, M., Liggi, S., Lewis, M.R., Correia, GDS, Sands, C.J., Takis, P., Maslen, L., Greenhalf, W., Shaw, V., McDonald, S.E., Ahmed, K.A., Armstrong, J.A., Ashworth, M., Asiimwe, I.G., Bakshi, S., Barlow, S.L., Booth, L., Brennan, B., Bullock, K., Catterall, BWA, Clark, J.J., Clarke, E.A., Cox, H., Dincarslan, O., Dunn, C., Dyer, P., Elliott, A., Evans, A., Finch, L., Fisher, LWS, Foster, T., Garcia-Dorival, I., Gunning, P., Hartley, C., Jensen, R.L., Jones, C.B., Jones, T.R., Khandaker, S., Kiy, R.T., Koukorava, C., Lake, A., Lant, S., Latawiec, D., Lavelle-Langham, L., Lefteri, D., Lett, L., Livoti, L.A., Mancini, M., McDonald, S., McEvoy, L., McLauchlan, J., Metelmann, S., Miah, N.S., Middleton, J., Mitchell, J., Murphy, E.G., Penrice-Randal, R., Pilgrim, J., Prince, T., Reynolds, W., Ridley, P.M., Sales, D., Shaw, V.E., Shears, R.K., Small, B., Subramaniam, K.S., Szemiel, A., Taggart, A., Tanianis-Hughes, J., Trochu, E., van Tonder, L., Wilcock, E., Zhang, J.E., Flaherty, L., Maziere, N., Cass, E., Carracedo, A.D., Carlucci, N., Holmes, A., Massey, H., Murphy, L., Wrobel, N., McCafferty, S., Morrice, K., MacLean, A., Armstrong, R., Boz, C., Coutts, A., Cullum, L., Day, N., Donnelly, L., Duncan, E., Fawkes, A., Finernan, P., Gilchrist, T., Golightly, A., Hafezi, K., Law, D., Law, R., Law, S., Macgillivray, L., Maclean, A., Mal, H., Mcmaster, E., Meikle, J., Oosthuyzen, W., Paterson, T., Stenhouse, A., Swets, M., Szoor-McElhinney, H., Taneski, F., Wackett, T., Ward, M., Weaver, J., Coyle, J., Gallagher, B., Lidstone-Scott, R., Hamilton, D., Schon, K., Furlong, A., Biggs, H., Griffiths, F., Andrews, E., Brickell, K., Smyth, M., Carson, G., Hardwick, H., Donohue, C., Neale, Benjamin M. [0000-0003-1513-6077], Apollo - University of Cambridge Repository, Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Guided Treatment in Optimal Selected Cancer Patients (GUTS), AII - Infectious diseases, Amsterdam Neuroscience - Neuroinfection & -inflammation, Neurology, Infectious diseases, Center of Experimental and Molecular Medicine, APH - Aging & Later Life, APH - Global Health, APH - Quality of Care, Amsterdam institute for Infection and Immunity, APH - Health Behaviors & Chronic Diseases, Global Health, APH - Methodology, Graduate School, ACS - Heart failure & arrhythmias, Anesthesiology, ACS - Diabetes & metabolism, APH - Digital Health, APH - Personalized Medicine, ACS - Microcirculation, Niemi, M. E. K., Liao, R. G., Neale, B. M., Pathak, G. A., Andrews, S. J., Schulte, E. C., Karim, M. A., Wendt, F. R., Kim, H. -N., Uddin, M. J., Smith, G. D., Willer, C. J., Buxbaum, J. D., Martin, A. R., Balaconis, M. K., Sankaran, V. G., Brent Richards, J., Eric Kerchberger, V., Kenneth Baillie, J., Dutta, A. K., Uddin, M. M., Perez-Tur, J., Verdugo, R. A., Zarate, R., Medina-Gomez, C., Gomez-Cabrero, D., Cadilla, C. L., Boua, P. R., Fave, M. -J., Lemacon, A., Szentpeteri, J. L., Ahmad, H. F., Kornilov, S. A., Prokic, I., Pearson, N. M., Shelton, J. F., Shastri, A. J., Weldon, C. H., Brouwer, M. C., Vlaar, A. P. J., Joost Wiersinga, W., Algera, A. G., Bogaard, H. J., Bonta, P. I., Grobusch, M. P., Hermans, S. M., Hovius, J. W., de Jong, M. D., Nossent, E. J., Prins, J. M., Schultz, M. J., Stijnis, C. S., Minnaar, R. P., van Uffelen, K. W. J., Wolterman, R. A., Ball, C. A., Mccurdy, S., Hong, E. L., Baltzell, A. H., Goffard, J. -C., Peree, H., Leonard, P., Giot, J. -B., Sauvage, A. -S., Wery, M., Morrison, D. R., Chasse, M., Kaufmann, D. E., Mark Lathrop, G., Davis, L. K., Cox, N. J., Below, J. E., Sealock, J. M., Faucon, A. B., Shuey, M. M., Polikowsky, H. G., Petty, L. E., Shaw, D. M., Chen, H. -H., Ludwig, K. U., Schroder, J., Nothen, M. M., Jensen, B. -E. O., Altmuller, J., Berger, M. M., Gogele, M., Gignoux, C. R., Wicks, S. J., Barnes, K. C., Goldstein, D. B., Reilly, M. P., Gharavi, A. G., O'Byrne, S. M., So, Y. S., Park, S. -K., Kim, H. -L., Kang, C. K., Lee, H. -J., Song, K. -H., Yoon, K. J., Paik, N. -J., Joo, E. -J., Park, W. B., Park, J. S., Park, K. U., Ham, S. Y., Kim, E. S., Kim, H. B., Caceres, M., Lenz, T. L., Julia, A., Holter, J. C., Fernandez, J., Sander, L. E., Banales, J. M., Romero-Gomez, M., Hov, J. R., Karlsen, T. H., Wacker, E. M., Elabd, H., Ruhlemann, M. C., Vadla, M. S., Lenning, O. B., Ozer, O., Kassens, J., Figuera Basso, M. E., Ortiz, A. B., Chercoles, A. G., Holten, A. R., Kildal, A. B., Gluck, A., Nolla, A. C., Dyrhol-Riise, A. M., Spinner, C. D., Hoff, D. A. L., Jimenez, D., Pestana, D., Helbig, E. T., Paraboschi, E. M., Sanchez, F. G., Hernandez, I., Galvan-Femenia, I., Badia, J. R., Muller, K. E., Gaede, K. I., Lippert, L. J., Tellez, L., Gutierrez-Stampa, M. A., Vehreschild, M. J. G. T., Marquie, M., Seilmaier, M. J., Rodriguez-Gandia, M., Ayo, N. I., Martinez, N., Cornely, O. A., Rodrigues, P. M., Espana, P. P., Garcia-Fernandez, A. -E., Fracanzani, A. L., Muniz-Diaz, E., Calderon, E. J., Solligard, E., Medrano, F. J., Muller, F., Afset, J. E., Damas, J. K., Ferrusquia-Acosta, J., Quero, J. H., Guerrero, J. M., Bettini, L. R., Gustad, L. T., Valsecchi, M. G., D'Angio, M., Gallego-Duran, R., Cejudo, T. G., Grimsrud, M. M., Gudbjartsson, D. F., Moore, K. H. S., Alarcon-Riquelme, M. E., Martinez-Bueno, M., Rello, S. R., Lall, K., Bochud, P. -Y., Nussle, S. G., Meyer zu Bentrup, F., Merlet Viollet, R., Guery, B., Hugli, O., Gonseth Nussle, S., Estoppey Younes, S., Rochat Negro, T., Mercader, J. M., Castano-Vinyals, G., Dobano, C., Mondelli, M. U., Mazzei, M. A., Caldarelli, G. P., Monforte, A. D., Scotton, P. G., Monica, M. D., Mandala, M., Coviello, D. A., La Rovere, M. T., Segala, F. V., Mencarelli, M. A., Pinto, A. M., Carriero, M. L., Ann Belli, M., Antoni, M. D., Miraglia, F. G., Parisi, S. G., Squeo, G. M., Botta, G., Hunt, K. A., Trembath, R. C., Martin, H. C., Griffiths, C. J., Curtis, C. J., Huang, Q. Q., Lee, S. H., Macarthur, D., Maclaughlin, B., Smith, A. V., Boughton, A. P., Li, K. W., Lefaive, J., Jannes, C. E., Krieger, J. E., Pereira, A. C., Lima, I. R., Tada, M. T., Mccarthy, M., Lee, J. E., Lee, H. S., Jang, H. Y., Kim, Y. -S., Kwon, K. T., Kim, S. -W., Kim, J. Y., Jang, Y. R., Kim, H., Lee, J. Y., Choe, K. -W., Kang, Y. M., Jee, S. H., Jung, K. J., Schroth, G. P., Desouza, F., Cirulli, E. T., Schiabor Barrett, K. M., Washington, N. L., Lu, J. T., Ramirez, J. M., Grzymski, J. J., Minano, J. I. E., Aguirre, L. A., Lopez-Collazo, E., Lozano-Rodriguez, R., Avendano-Ortiz, J., Arcos, V. T., Montalban-Hernandez, K. M., Quiroga, J. V., Martin-Quiros, A., Nakada, T. -A., Vonk, J. M., Ori, A. P. S., Hernandez Cordero, A. I., Sin, D. D., Bosse, Y., Feng, Y. -C. A., Weiss, S. T., Karlson, E. W., Smoller, J. W., Murphy, S. N., Meigs, J. B., Woolley, A. E., Green, R. C., Perez, E. F., Zollner, S., Sloofman, L. G., Sebra, R. P., Collins, B. L., Sealfon, S. C., Jordan, D. M., Thompson, R. C., Belbin, G. M., Underwood, S. J., Hiester, L. L., Charney, A. W., Beckmann, N. D., Schadt, E. E., Abul-Husn, N. S., Cho, J. H., Kenny, E. E., Loos, R. J. F., Nadkarni, G. N., Huckins, L. M., Ferreira, M. A. R., Abecasis, G. R., Leader, J. B., Cantor, M. N., Justice, A. E., Carey, D. J., Josyula, N. S., Kosmicki, J. A., Horowitz, J. E., Gass, M. C., Hottenga, J. J., de Geus, E. J. C., Nivard, M. G., Ritchie, M. D., Verma, S. S., Vari, M. S., Rahier, J. -F., Bulik, C. M., Landen, M., Ferrero, G. B., Fundin, B., Ismail, S. I., Badji, R. M., Hultstrom, M., Geschwind, D. H., Butte, M. J., Chang, T. S., Caulfield, M. J., Scott, R. H., Odhams, C. A., Karczewski, K. J., Wilson, D. J., Spencer, C. A., Crook, D. W., Wyllie, D. H., O'Connell, A. M., Atkinson, E. G., Walters, R. K., Palmer, D. S., Goldstein, J. I., Kyle Satterstrom, F., Earle, S. G., Lin, S. -K., Rudkin, J. K., Zhao, J. H., Butterworth, A. S., Sun, Y. V., Huffman, J. E., O'Donnell, C. J., Michael Gaziano, J., Ho, Y. -L., Glessner, J. R., Mcguigan, P. J., Moore, L. S. P., Vizcaychipi, M. P., Page, V. J., Aldera, E. L., Cutino-Moguel, M. -T., Durand, I., Hawcutt, D. B., Macmahon, M., Macnaughton, E., Mccullough, K., Mcewen, R., O'Shea, M. K., Pooni, J. S., Wooton, D. G., Bretherick, A. D., Fourman, M. H., Meynert, A. M., Ponting, C. P., Porteous, D. J., Russell, C. D., Wilson, J. F., Drake, T. M., Fairfield, C. J., Knight, S. R., Mclean, K. A., Shaw, C. A., Ho, A. Y. W., Horby, P. W., Mcauley, D., Openshaw, P. J. M., Semple, M. G., Mcgowan, J., Mcguinness, H., Mcneela, F., Bayo, L. -A., Arias, S. S., Conyngham, J. -A., Corral, M. A., de Almeida Martins, L. G., Mclaughlan, D., Mcmorrow, L., Mccormick, J., Mitchell, A. M., Maccallum, N., Hughes, R. A., Jones, T. O., Mcphail, M., Mckenley, I., Sutherland, S. -B., de Gordoa, L. O. -R., Gude, E. T., Macgoey, P., Mckenna, E., Patel, B. V., Zborowski, A. C., Garcia, S. M., Howe, G. S., Heron, A. E., Mills, G. H., Brown, C. W., Akhtar, M. N., Delgado, C. C., Saluzzio, R. P., Da Gloria, E. F., Hurt, W. J., Wood, H. -L., Mcalindon, M., Mccurdy, A., Ali, I. A. M., Ally, S. M., Hamilton, D. O., Lopez Martinez, M., Waite, A. A. C., Welters, I. D., Rosa, A. D., Baikady, R. R., Tatham, K. C., Beith, C. M., Mcgregor, A., Mcivor, S., Allison, K. S., Jones, G. A. L., Mchugh, T., Peters, M. J., Tomas, A. L., Mckechnie, S., Mccormack, L., Michael, H. T., Durrans, L. J., Suarez, J. C., Death, Y., Mccormick, W., Mccreath, G., Rai, S. G., Mcculloch, C., Mcfarland, D., Barclay, W. S., Cooke, G. S., Docherty, A. B., Green, C. A., Harrison, E. M., Hiscox, J. A., Lim, W. S., Mentzer, A. J., Paxton, W. A., Robertson, D. L., Scott, J. T., Tedder, R. S., Thomson, E. C., Thwaites, R. S., Gupta, R. K., Swann, O. V., Dumas, M. -E., Griffin, J. L., Lewis, M. R., dos Santos Correia, G., Sands, C. J., Mcdonald, S. E., Ahmed, K. A., Armstrong, J. A., Asiimwe, I. G., Barlow, S. L., Catterall, B. W. A., Clark, J. J., Clarke, E. A., Fisher, L. W. S., Jensen, R. L., Jones, C. B., Jones, T. R., Kiy, R. T., Livoti, L. A., Mcdonald, S., Mcevoy, L., Mclauchlan, J., Miah, N. S., Moore, S. C., Murphy, E. G., Matthew Ridley, P., Shaw, V. E., Shears, R. K., Subramaniam, K. S., Eunice Zhang, J., Carracedo, A. D., Mccafferty, S., Turtle, L. C. W., Data Science Genetic Epidemiology Lab, Institute for Molecular Medicine Finland, HUS Helsinki and Uusimaa Hospital District, University of Helsinki, Research Programs Unit, Doctoral Programme in Population Health, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, and University of Zurich
Subjects: Male, 45/43, Autoimmunity, Autoimmunity/genetics, Body Mass Index, COVID-19/genetics, COVID-19/virology, Critical Illness, Female, Genetic Loci/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Geographic Mapping, Hospitalization, Host-Pathogen Interactions/genetics, Humans, Inflammation/complications, Information Dissemination, Multifactorial Inheritance, Racial Groups/genetics, SARS-CoV-2/pathogenicity, Smoking, environmental risk factors, Q1, 631/208, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genetics, Genome-wide association studies, SARS-CoV-2, Viral infection, GWAS, Aetiology, Lung, QC, 0303 health sciences, HERITABILITY, 3. Good health, covid-19, Science & Technology - Other Topics, Identification (biology), Infection, Human, 631/208/205/2138, Settore BIO/11 - Biologia Molecolare, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Clinical Research, Biodefense, Genetics, GENOME-WIDE ASSOCIATION, Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714 [VDP], METAANALYSIS, 1000 Multidisciplinary, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, Prevention, Racial Groups, Pneumonia, genetic architecture, Human genetics, Genetic Loci, genetic factors, 570 Life sciences, biology, 030217 neurology & neurosurgery, Medizin, Infektionsmedicin, Genome-wide association studies, Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, Pandemic, 2.1 Biological and endogenous factors, pandemi, Multidisciplinary, article, Public Health, Global Health, Social Medicine and Epidemiology, Racial Group, 10124 Institute of Molecular Life Sciences, Host-Pathogen Interaction, Multidisciplinary Sciences, Infectious Diseases, Host-Pathogen Interactions, Critical Illne, COVID-19, GWAS, genetic factors, environmental risk factors, therapy, Infectious Medicine, Coronavirus disease 2019 (COVID-19), SUSCEPTIBILITY LOCI, General Science & Technology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Computational biology, Biology, Vaccine Related, 692/699/255/2514, Environmental risk, Mendelian randomization, COVID-19 Host Genetics Initiative, QH426, 631/326/596/4130, 030304 developmental biology, Inflammation, therapy, SARS-CoV-2, Human Genome, COVID-19, Genetic architecture, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Emerging Infectious Diseases, Good Health and Well Being, Viral infection, 3111 Biomedicine
Abstract: Niemi, Mari E. K. et al. 39 páginas, figuras y tablas. Contiene material suplementario., The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3-7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
Published: 2021
Full Text: View/download PDF

13. Adverse events in survival data: from clinical questions to methods for statistical analysis

Author: Tassistro E, Antolini L, Bernasconi DP, Valsecchi MG, Tassistro, E, Antolini, L, Bernasconi, D, and Valsecchi, M
Subjects: survival analysis, adverse events, competing risks, inverse probability of censoring weighting
Abstract: When studying a novel treatment with a survival time outcome, failure can be defined to include a serious adverse event (AE) among the endpoints typically considered, for instance relapse (RL) or progression. These events act as competing risks, where the occurrence of RL as first event and the subsequent treatment change exclude the possibility of observing AE related to the treatment itself. In principle, the analysis of AE could be tackled by two different approaches: 1. the description of the observed occurrence of AE as first event: treatment ability to protect from RL has an impact on the chance of observing AE due to the competing risks action. The more the treatment protects from RL, the greater is the chance to observe an AE as first event; 2. the assessment of the treatment impact on the development of AE in patients who are RL free in time: one should consider the occurrence of AE as if RL would not exclude the possibility of observing AE related to the treatment itself. In the first part of the presentation we review the strategy of analysis for the two approaches starting from the type of clinical question of interest. Then we identify the suitable quantities and estimators according to two features, usually needed in a survival context: - the estimator should address for the presence of right censoring - the theoretical quantity and estimator should be functions of time. In the second part of the presentation we propose alternative methods, such as regression models, stratified Kaplan-Meier curves and inverse probability of censoring weighting, to relax the assumption of independence between the potential time to AE and the potential time to RL. We show through simulations that these methods overcome the problems related to the use of standard competing risks estimators in the second approach.
Published: 2021

14. Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia

Author: Andres-Jensen, L, Attarbaschi, A, Bardi, E, Barzilai-Birenboim, S, Bhojwani, D, Hagleitner, M, Halsey, C, Harila-Saari, A, van Litsenburg, R, Hudson, M, Jeha, S, Kato, M, Kremer, L, Mlynarski, W, Moricke, A, Pieters, R, Piette, C, Raetz, E, Ronceray, L, Toro, C, Valsecchi, M, Vrooman, L, Weinreb, S, Winick, N, Schmiegelow, K, Hagleitner, MM, van Litsenburg, RRL, Hudson, MM, Valsecchi, MG, Vrooman, LM, Andres-Jensen, L, Attarbaschi, A, Bardi, E, Barzilai-Birenboim, S, Bhojwani, D, Hagleitner, M, Halsey, C, Harila-Saari, A, van Litsenburg, R, Hudson, M, Jeha, S, Kato, M, Kremer, L, Mlynarski, W, Moricke, A, Pieters, R, Piette, C, Raetz, E, Ronceray, L, Toro, C, Valsecchi, M, Vrooman, L, Weinreb, S, Winick, N, Schmiegelow, K, Hagleitner, MM, van Litsenburg, RRL, Hudson, MM, Valsecchi, MG, and Vrooman, LM
Abstract: 5-year overall survival rates have surpassed 90% for childhood acute lymphocytic leukaemia, but survivors are at risk for permanent health sequelae. Although event-free survival appropriately represents the outcome for cancers with poor overall survival, this metric is inadequate when cure rates are high but challenged by serious, persistent complications. Accordingly, a group of experts in paediatric haematology-oncology, representative of 17 international acute lymphocytic leukaemia study groups, launched an initiative to construct a measure, designated severe toxicity-free survival (STFS), to quantify the occurrence of physician-prioritised toxicities to be integrated with standard cancer outcome reporting. Five generic inclusion criteria (not present before cancer diagnosis, symptomatic, objectifiable, of unacceptable severity, permanent, or requiring unacceptable treatments) were used to assess 855 health conditions, which resulted in inclusion of 21 severe toxicities. Consensus definitions were reached through a modified Delphi process supplemented by two additional plenary meetings. The 21 severe toxicities include severe adverse health conditions that substantially affect activities of daily living and are refractory to therapy (eg, refractory seizures), are without therapeutic options (eg, blindness), or require substantially invasive treatment (eg, cardiac transplantation). Incorporation of STFS assessment into clinical trials has the potential to improve and diversify treatment strategies, focusing not only on traditional outcome events and overall survival but also the frequencies of the most severe toxicities. The two major aims of this Review were to: prioritise and define unacceptable long-term toxicity for patients with childhood acute lymphocytic leukaemia, and define how these toxicities should be combined into a composite quantity to be integrated with other reported outcomes. Although STFS quantifies the clinically unacceptable health tradeoff fo
Published: 2021

15. Infant T-cell acute lymphoblastic leukaemia with t(6;7) (TCRB-MYB) translocation

Author: Ramdeny, P, Mullanfroze, K, de Lorenzo, P, Valsecchi, M, Meijerink, J, Pieters, R, Baruchel, A, Vora, A, Ramdeny, PS, Valsecchi, MG, Ramdeny, P, Mullanfroze, K, de Lorenzo, P, Valsecchi, M, Meijerink, J, Pieters, R, Baruchel, A, Vora, A, Ramdeny, PS, and Valsecchi, MG
Abstract: T-ALL is rare in infancy with only 10 (1.5%) of 651 patients of that subtype in the Interfant-06 infant ALL trial. We report 3 cases of t(6;7) (TCR/MYB) infant T-cell Acute Lymphoblastic Leukaemia who appear to have a distinct clinical presentation with CNS disease and refractory disease or late relapse.
Published: 2021

16. Adverse events in survival data: from clinical questions to methods for statistical analysis

Author: Tassistro, E, Antolini, L, Bernasconi, D, Valsecchi, M, Tassistro E, Antolini L, Bernasconi DP, Valsecchi MG, Tassistro, E, Antolini, L, Bernasconi, D, Valsecchi, M, Tassistro E, Antolini L, Bernasconi DP, and Valsecchi MG
Abstract: When studying a novel treatment with a survival time outcome, failure can be defined to include a serious adverse event (AE) among the endpoints typically considered, for instance relapse (RL) or progression. These events act as competing risks, where the occurrence of RL as first event and the subsequent treatment change exclude the possibility of observing AE related to the treatment itself. In principle, the analysis of AE could be tackled by two different approaches: 1. the description of the observed occurrence of AE as first event: treatment ability to protect from RL has an impact on the chance of observing AE due to the competing risks action. The more the treatment protects from RL, the greater is the chance to observe an AE as first event; 2. the assessment of the treatment impact on the development of AE in patients who are RL free in time: one should consider the occurrence of AE as if RL would not exclude the possibility of observing AE related to the treatment itself. In the first part of the presentation we review the strategy of analysis for the two approaches starting from the type of clinical question of interest. Then we identify the suitable quantities and estimators according to two features, usually needed in a survival context: - the estimator should address for the presence of right censoring - the theoretical quantity and estimator should be functions of time. In the second part of the presentation we propose alternative methods, such as regression models, stratified Kaplan-Meier curves and inverse probability of censoring weighting, to relax the assumption of independence between the potential time to AE and the potential time to RL. We show through simulations that these methods overcome the problems related to the use of standard competing risks estimators in the second approach.
Published: 2021

17. Cluster analysis reveals the prognostic role of serum albumin within the normal range in patients with primary biliary cholangitis

Author: Gerussi, A, Verda, D, Bernasconi, D, Carbone, M, Komori, A, Abe, M, Inao, M, Namisaki, T, Mochida, S, Yoshiji, H, Hirschfield, G, Lindor, K, Pares, A, Corpechot, C, Cazzagon, N, Floreani, A, Marzioni, M, Alvaro, D, Gentilucci, U, Cristoferi, L, Valsecchi, M, Muselli, M, Hansen, B, Tanaka, A, Invernizzi, P, Lindor, KD, Gentilucci, UV, Valsecchi, MG, Gerussi, A, Verda, D, Bernasconi, D, Carbone, M, Komori, A, Abe, M, Inao, M, Namisaki, T, Mochida, S, Yoshiji, H, Hirschfield, G, Lindor, K, Pares, A, Corpechot, C, Cazzagon, N, Floreani, A, Marzioni, M, Alvaro, D, Gentilucci, U, Cristoferi, L, Valsecchi, M, Muselli, M, Hansen, B, Tanaka, A, Invernizzi, P, Lindor, KD, Gentilucci, UV, and Valsecchi, MG
Published: 2021

18. Clustering Reveals the Prognostic Role of Serum Albumin Values Within the Normal Range in Patients with Primary Biliary Cholangitis

Author: Gerussi, A, Verda, D, Bernasconi, D, Carbone, M, Komori, A, Abe, M, Inao, M, Namisaki, T, Mochida, S, Yoshiji, H, Hirschfield, G, Lindor, K, Pares, A, Corpechot, C, Cazzagon, N, Floreani, A, Marzioni, M, Alvaro, D, Vespasiani-Gentilucci, U, Cristoferi, L, Valsecchi, M, Muselli, M, Hansen, B, Tanaka, A, Invernizzi, P, Bernasconi, DP, Valsecchi, MG, Hansen, BE, Gerussi, A, Verda, D, Bernasconi, D, Carbone, M, Komori, A, Abe, M, Inao, M, Namisaki, T, Mochida, S, Yoshiji, H, Hirschfield, G, Lindor, K, Pares, A, Corpechot, C, Cazzagon, N, Floreani, A, Marzioni, M, Alvaro, D, Vespasiani-Gentilucci, U, Cristoferi, L, Valsecchi, M, Muselli, M, Hansen, B, Tanaka, A, Invernizzi, P, Bernasconi, DP, Valsecchi, MG, and Hansen, BE
Published: 2021

19. Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer

Author: Bajetta, E., Floriani, I., Di Bartolomeo, M., Labianca, R., Falcone, A., Di Costanzo, F., Comella, G., Amadori, D., Pinto, C., Carlomagno, C., Nitti, D., Daniele, B., Mini, E., Poli, D., Santoro, A., Mosconi, S., Casaretti, R., Boni, C., Pinotti, G., Bidoli, P., Landi, L., Rosati, G., Ravaioli, A., Cantore, M., Di Fabio, F., Aitini, E., Marchet, A., Floriani, I., Rulli, E., Cropalato Di Tullio, M., Poli, D., Galli, F., Biagioli, E., De Simone, I., Poli, D., Mangano, S., Tonato, M., Zucca, E., Valsecchi, MG., Floriani, I., Bajetta, E., Di Bartolomeo, M., Labianca, R., Amadori, D., Falcone, A., Di Costanzo, F., Daniele, B., Pinto, C., Comella, G., Nitti, D., Mini, E., De Placido, S., Marchet, A., Bajetta, E., Di Bartolomeo, M., Catena, L., Schiavo, M., Pinotti, G., Proserpio, I., Rosati, G., Bordonaro, R., Cordio, S., Burrafato, G., Bochicchio, A.M., Aieta, M., Fazio, N., Spada, F., Amoroso, V., Marini, G., Soto Parra, H., Novello, G., Massidda, B., Ionta, M.T., Comandè, M., Venezia, R., Bertolini, A., Menatti, E., Zanlorenzi, L., Colombo, A., Iop, A., Bonura, S., Mazza, E., Viganò, M., Ardizzoia, A., DellʼOro, S., Lo Re, G., Santeufemia, D., Buonadonna, A., Luisi, D., Ucci, G., Di Lucca, G., Bonetti, A., Bergamo, F., Alù, M., Vastola, F., Marchetti, P., Corsi, D.C., Massa, E., Di Pinto, G., Duro, M., Oliani, C., Franchini, M., Inzoli, A., Gebbia, N., Repetto, L., Rota, S., Frontini, L., Labianca, R., Mosconi, S., Quadri, A., De Grossi, S., Bidoli, P., Cazzaniga, M.E., Villa, F., Foa, P., Ferrari, D., Aitini, E., Rabbi, C., Barni, S., Petrelli, F., Giordano, M., Luchena, G., Pirovano, M., Nasisi, A., Catalano, V., Giordani, P., Zaniboni, A., Leone, F., Ferrario, S., Beretta, G.D., Menichetti, E.T., Conte, D., Mari, D., Giannicola, R., Pierantoni, C., Luporini, A.G., Ravaioli, A., Tassinari, D., Nicolini, M., Amadori, D., Frassineti, G.L., Turci, D., Zumaglini, F., Tamberi, S., Piancastelli, A., Cruciani, G., Falcone, A., Landi, L., Minuti, G., Cantore, M., Orlandi, M., Mambrini, A., Ciarlo, A., Cavaciocchi, D., Del Monte, F., Ricci, S., Brunetti, M.I., Lencioni, M., Sisani, M., Sozzi, P., Granetto, C., Chiara, S., Galetto, A.S., Ribecco, A.S., DeCensi, A., Ciuffreda, L., Baldini, E.E., Camisa, R., Todeschini, R., Santoro, A., Rimassa, L., Carnaghi, C., Pressiani, T., Boni, C., Rondini, E., Gnoni, R., Di Costanzo, F., Gasperoni, S., Cavanna, L., Palladino, M.A., Mattioli, R., Laici, G., Pucci, F., Alessio, M.D., Bernardini, I., Tomasello, G., Baldino, G., Rossetti, R., Giaquinta, S., Pinto, C., Di Fabio, F., Rijas Llimpe, F.L., Brandes, A.A., Marzola, M., Montesarchio, V., Rea, A., Daniele, B., Genua, G., Casaretti, R., Silvestro, L., Montano, M., Sarobba, M.G., Sanna, G., Filippelli, G., Dima, G., Greco, E., Roselli, M., Natale, D., Condemi, G., Fumi, G., Tafuto, S., Masullo, P., Nitti, D., Marchet, A., Tiberio, G., de Manzoni, G., Fiorentini, G., Mazzanti, R., Carlomagno, C., De Stefano, A., Cartenì, G., and Otero, M.
Published: 2014
Full Text: View/download PDF

20. Genomewide Association Study of Severe Covid-19 with Respiratory Failure

Author: Ellinghaus, D, Degenhardt, F, Bujanda, L, Buti, M, Albillos, A, Invernizzi, P, Fernandez, J, Prati, D, Baselli, G, Asselta, R, Grimsrud, MM, Milani, C, Aziz, F, Kassens, J, May, S, Wendorff, M, Wienbrandt, L, Uellendahl-Werth, F, Zheng, TH, Yi, XL, de Pablo, R, Chercoles, AG, Palom, A, Garcia-Fernandez, AE, Rodriguez-Frias, F, Zanella, A, Bandera, A, Protti, A, Aghemo, A, Lleo, A, Biondi, A, Caballero-Garralda, A, Gori, A, Tanck, A, Nolla, AC, Latiano, A, Fracanzani, AL, Peschuck, A, Julia, A, Pesenti, A, Voza, A, Jimenez, D, Mateos, B, Jimenez, BN, Quereda, C, Paccapelo, C, Gassner, C, Angelini, C, Cea, C, Solier, A, Pestana, D, Muniz-Diaz, E, Sandoval, E, Paraboschi, EM, Navas, E, Sanchez, FG, Ceriotti, F, Martinelli-Boneschi, F, Peyvandi, F, Blasi, F, Tellez, L, Blanco-Grau, A, Hemmrich-Stanisak, G, Grasselli, G, Costantino, G, Cardamone, G, Foti, G, Aneli, S, Kurihara, H, ElAbd, H, My, I, Galvan-Femenia, I, Martin, J, Erdmann, J, Ferrusquia-Acosta, J, Garcia-Etxebarria, K, Izquierdo-Sanchez, L, Bettini, LR, Sumoy, L, Terranova, L, Moreira, L, Santoro, L, Scudeller, L, Mesonero, F, Roade, L, Ruhlemann, MC, Schaefer, M, Carrabba, M, Riveiro-Barciela, M, Basso, MEF, Valsecchi, MG, Hernandez-Tejero, M, Acosta-Herrera, M, D'Angio, M, Baldini, M, Cazzaniga, M, Schulzky, M, Cecconi, M, Wittig, M, Ciccarelli, M, Rodriguez-Gandia, M, Bocciolone, M, Miozzo, M, Montano, N, Braun, N, Sacchi, N, Martinez, N, Ozer, O, Palmieri, O, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Tentorio, P, Castro, P, Rodrigues, PM, Blandino, A, de Cid, R, Ferrer, R, Gualtierotti, R, Nieto, R, Goerg, S, Badalamenti, S, Marsal, S, Matullo, G, Pelusi, S, Juzenas, S, Aliberti, S, Monzani, V, Moreno, V, Wesse, T, Lenz, TL, Pumarola, T, Rimoldi, V, Bosari, S, Albrecht, W, Peter, W, Romero-Gomez, M, D'Amato, M, Duga, S, Banales, JM, Hov, JR, Folseraas, T, Valenti, L, Franke, A, and Karlsen, TH
Abstract: BackgroundThere is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. MethodsWe conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case-control panels. ResultsWe detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P
Published: 2020

21. Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols

Author: Cario, G, Leoni, V, Conter, V, Attarbaschi, A, Zaliova, M, Sramkova, L, Cazzaniga, G, Fazio, G, Sutton, R, Elitzur, S, Izraeli, S, Lauten, M, Locatelli, F, Basso, G, Buldini, B, Bergmann, AK, Lentes, J, Steinemann, D, Göhring, G, Schlegelberger, B, Haas, OA, Schewe, D, Buchmann, S, Moericke, A, White, D, Revesz, T, Stanulla, M, Mann, G, Bodmer, N, Arad-Cohen, N, Zuna, J, Valsecchi, MG, Zimmermann, M, Schrappe, M, Biondi, A, Cario, G, Leoni, V, Conter, V, Attarbaschi, A, Zaliova, M, Sramkova, L, Cazzaniga, G, Fazio, G, Sutton, R, Elitzur, S, Izraeli, S, Lauten, M, Locatelli, F, Basso, G, Buldini, B, Bergmann, AK, Lentes, J, Steinemann, D, Göhring, G, Schlegelberger, B, Haas, OA, Schewe, D, Buchmann, S, Moericke, A, White, D, Revesz, T, Stanulla, M, Mann, G, Bodmer, N, Arad-Cohen, N, Zuna, J, Valsecchi, MG, Zimmermann, M, Schrappe, M, and Biondi, A
Abstract: ABL-class fusions other than BCR-ABL1 characterize around 2-3% of precursor B-cell acute lymphoblastic leukemia. Case series indicated that patients suffering from these subtypes have a dismal outcome and may benefit from the introduction of tyrosine kinase inhibitors. We analyzed clinical characteristics and outcome of 46 ABL-class fusion positive cases other than BCR-ABL1 treated according to AIEOP-BFM (Associazione Italiana di Ematologia-Oncologia Pediatrica-Berlin-Frankfurt-Münster) ALL 2000 and 2009 protocols; 13 of them received a tyrosine kinase inhibitor (TKI) during different phases of treatment. ABL-class fusion positive cases had a poor early treatment response: minimal residual disease levels of ≥5x10-4 were observed in 71.4% of patients after induction treatment and in 51.2% after consolidation phase. For the entire cohort of 46 cases, the 5-year probability of event-free survival was 49.1+8.9% and that of overall survival 69.6+7.8%; the cumulative incidence of relapse was 25.6+8.2% and treatment-related mortality (TRM) 20.8+6.8%. One out of 13 cases with TKI added to chemotherapy relapsed while eight of 33 cases without TKI treatment suffered from relapse, including six in 17 patients who had not received hematopoietic stem cell transplantation. Stem cell transplantation seems to be effective in preventing relapses (only three relapses in 25 patients), but was associated with a very high TRM (6 patients). These data indicate a major need for an early identification of ABL-class fusion positive acute lymphoblastic leukemia cases and to establish a properly designed, controlled study aimed at investigating the use of TKI, the appropriate chemotherapy backbone and the role of hematopoietic stem cell transplantation. (Registered at: clinicaltrials.gov identifier: NTC00430118, NCT00613457, NCT01117441).
Published: 2020

22. Modeling the hazard of transition into the absorbing state in the illness-death model

Author: Tassistro, E, Bernasconi, D, Rebora, P, Valsecchi, M, Antolini, L, Bernasconi, DP, Valsecchi, MG, Tassistro, E, Bernasconi, D, Rebora, P, Valsecchi, M, Antolini, L, Bernasconi, DP, and Valsecchi, MG
Abstract: The illness-death model is the simplest multistate model where the transition from the initial state 0 to the absorbing state 2 may involve an intermediate state 1 (e.g., disease relapse). The impact of the transition into state 1 on the subsequent transition hazard to state 2 enables insight to be gained into the disease evolution. The standard approach of analysis is modeling the transition hazards from 0 to 2 and from 1 to 2, including time to illness as a time-varying covariate and measuring time from origin even after transition into state 1. The hazard from 1 to 2 can be also modeled separately using only patients in state 1, measuring time from illness and including time to illness as a fixed covariate. A recently proposed approach is a model where time after the transition into state 1 is measured in both scales and time to illness is included as a time-varying covariate. Another possibility is a model where time after transition into state 1 is measured only from illness and time to illness is included as a fixed covariate. Through theoretical reasoning and simulation protocols, we discuss the use of these models and we develop a practical strategy aiming to (a) validate the properties of the illness-death process, (b) estimate the impact of time to illness on the hazard from state 1 to 2, and (c) quantify the impact that the transition into state 1 has on the hazard of the absorbing state. The strategy is also applied to a literature dataset on diabetes.
Published: 2020

23. Transplant-related toxicity and mortality: an AIEOP prospective study in 636 pediatric patients transplanted for acute leukemia

Author: Balduzzi, A, Valsecchi, MG, Silvestri, D, Locatelli, F, Manfredini, L, Busca, A, Iori, AP, Messina, C, Prete, A, Andolina, M, Porta, F, Favre, C, Ceppi, S, Giorgiani, G, Lanino, E, Rovelli, A, Fagioli, F, De Fusco, C, Rondelli, R, and Uderzo, C
Published: 2002
Full Text: View/download PDF

24. Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Acute Lymphoblastic Leukemia Studies, 1982–1995

Author: Conter, V, Aricò, M, Valsecchi, MG, Basso, G, Biondi, A, Madon, E, Mandelli, F, Paolucci, G, Pession, A, Rizzari, C, Rondelli, R, Zanesco, L, and Masera, G
Published: 2000
Full Text: View/download PDF

25. Molecular detection of minimal residual disease is a strong predictive factor of relapse in childhood B-lineage acute lymphoblastic leukemia with medium risk features. A case control study of the International BFM study group

Author: Biondi, A, Valsecchi, MG, Seriu, T, D'Aniello, E, Willemse, MJ, Fasching, K, Pannunzio, A, Gadner, H, Schrappe, M, Kamps, WA, Bartram, CR, van Dongen, JJM, and Panzer-Grümayer, ER
Published: 2000
Full Text: View/download PDF

26. Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation

Author: Uderzo, C, Fumagalli, M, De Lorenzo, P, Busca, A, Vassallo, E, Bonanomi, S, Lanino, E, Dini, G, Varotto, S, Messina, C, Miniero, R, Valsecchi, MG, and Balduzzi, A
Published: 2000
Full Text: View/download PDF

27. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia

Author: Messina, C, Valsecchi, MG, Aricò, M, Locatelli, F, Rossetti, F, Rondelli, R, Cesaro, S, Uderzo, C, Conter, V, Pession, A, Sotti, G, Loiacono, G, Santoro, N, Miniero, R, Dini, G, Favre, C, Meloni, G, Testi, AM, Werner, B, Silvestri, D, Arrighini, A, Varotto, S, Pillon, M, Basso, G, Lombardi, A, Masera, G, and Zanesco, L
Published: 1998
Full Text: View/download PDF

28. Modelling the hazard of transition into the absorbing state in the illness-death model

Author: Tassistro, E, Bernasconi, DP, Rebora, P, Valsecchi, MG, Antolini L, Tassistro, E, Bernasconi, D, Rebora, P, Valsecchi, M, and Antolini, L
Subjects: transition hazard, time scale, illness-death, survival, Markov model, MED/01 - STATISTICA MEDICA
Abstract: The illness-death model is the simplest multistate model where the transition from an initial state 0 to an absorbing state 2 may involve also an intermediate state 1 (e.g. disease relapse). The impact of the transition into state 1 on the subsequent hazard of the absorbing state enables to increase the knowledge about the evolution of the disease. The approaches commonly applied to analyse illness-death data depend on the choice of the time scale(s) used to measure follow-up time after the transition to illness. In multistate literature, the original (or “clock forward”) time scale is commonly used to measure follow-up time for subjects in state 0 and can be considered also for those in state 1, since time from the initial state can be measured even after the transition to illness. The time to such transition can be included as covariate in models estimated on the entire set of subjects (full-sample models). The follow-up time after the transition to state 1 can be measured also in the “clock reset” scale, which uses the intermediate state as a new origin. In this case, models are commonly estimated only on the subjects who develop illness (sub-sample models) and the time of occurrence of the intermediate event can be included as a covariate. An approach proposed in literature consists in a model where the follow-up time after the transition into the intermediate state is measured in both scales and time to illness is included as a time-varying covariate. A further possibility is to measure the follow-up time in the clock forward scale before the transition into state 1 and in the clock reset scale after that transition. Through theoretical reasoning and simulation protocols we developed practical strategies a statistician can follow to: (a) validate the Markov, semi-Markov and extended semi-Markov properties of the illness-death process, from which the choice of the scale to measure time after illness, for the transition hazard into the absorbing state, depends; (b) estimate the impact of time to the intermediate event on the hazard from the illness state to the absorbing state, proposing also a novel modelling approach that ensures the interpretability of the model coefficient of the time to illness in case of non-Markov data; (c) quantify the impact that the transition into the intermediate state has on the hazard of the absorbing state.
Published: 2019

29. Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study

Author: Ferrua, F, Cicalese, M, Galimberti, S, Giannelli, S, Dionisio, F, Barzaghi, F, Migliavacca, M, Bernardo, M, Calbi, V, Assanelli, A, Facchini, M, Fossati, C, Albertazzi, E, Scaramuzza, S, Brigida, I, Scala, S, Basso-Ricci, L, Pajno, R, Casiraghi, M, Canarutto, D, Salerio, F, Albert, M, Bartoli, A, Wolf, H, Fiori, R, Silvani, P, Gattillo, S, Villa, A, Biasco, L, Dott, C, Culme-Seymour, E, van Rossem, K, Atkinson, G, Valsecchi, M, Roncarolo, M, Ciceri, F, Naldini, L, Aiuti, A, Cicalese, MP, Bernardo, ME, Assanelli, AA, Albert, MH, Wolf, HM, Fiori, Rossan, Culme-Seymour, EJ, Valsecchi, MG, Roncarolo, MG, Ferrua, F, Cicalese, M, Galimberti, S, Giannelli, S, Dionisio, F, Barzaghi, F, Migliavacca, M, Bernardo, M, Calbi, V, Assanelli, A, Facchini, M, Fossati, C, Albertazzi, E, Scaramuzza, S, Brigida, I, Scala, S, Basso-Ricci, L, Pajno, R, Casiraghi, M, Canarutto, D, Salerio, F, Albert, M, Bartoli, A, Wolf, H, Fiori, R, Silvani, P, Gattillo, S, Villa, A, Biasco, L, Dott, C, Culme-Seymour, E, van Rossem, K, Atkinson, G, Valsecchi, M, Roncarolo, M, Ciceri, F, Naldini, L, Aiuti, A, Cicalese, MP, Bernardo, ME, Assanelli, AA, Albert, MH, Wolf, HM, Fiori, Rossan, Culme-Seymour, EJ, Valsecchi, MG, and Roncarolo, MG
Abstract: Background: Wiskott-Aldrich syndrome is a rare, life-threatening, X-linked primary immunodeficiency characterised by microthrombocytopenia, infections, eczema, autoimmunity, and malignant disease. Lentiviral vector-mediated haemopoietic stem/progenitor cell (HSPC)gene therapy is a potentially curative treatment that represents an alternative to allogeneic HSPC transplantation. Here, we report safety and efficacy data from an interim analysis of patients with severe Wiskott-Aldrich syndrome who received lentiviral vector-derived gene therapy. Methods: We did a non-randomised, open-label, phase 1/2 clinical study in paediatric patients with severe Wiskott-Aldrich syndrome, defined by either WAS gene mutation or absent Wiskott-Aldrich syndrome protein (WASP)expression or a Zhu clinical score of 3 or higher. We included patients who had no HLA-identical sibling donor available or, for children younger than 5 years of age, no suitable 10/10 matched unrelated donor or 6/6 unrelated cord blood donor. After treatment with rituximab and a reduced-intensity conditioning regimen of busulfan and fludarabine, patients received one intravenous infusion of autologous CD34+ cells genetically modified with a lentiviral vector encoding for human WAS cDNA. The primary safety endpoints were safety of the conditioning regimen and safety of lentiviral gene transfer into HSPCs. The primary efficacy endpoints were overall survival, sustained engraftment of genetically corrected HSPCs, expression of vector-derived WASP, improved T-cell function, antigen-specific responses to vaccinations, and improved platelet count and mean platelet volume normalisation. This interim analysis was done when the first six patients treated had completed at least 3 years of follow-up. The planned analyses are presented for the intention-to-treat population. This trial is registered with ClinicalTrials.gov (number NCT01515462)and EudraCT (number 2009-017346-32). Findings: Between April 20, 2010, and Feb 26, 201
Published: 2019

30. ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells

Author: Portale, F, Cricrì, G, Bresolin, S, Lupi, M, Gaspari, S, Silvestri, D, Russo, B, Marino, N, Ubezio, P, Pagni, F, Vergani, P, Te Kronnie, G, Valsecchi, M, Locatelli, F, Rizzari, C, Biondi, A, Dander, E, D'Amico, G, Portale F, Cricrì G, Bresolin S, Lupi M, Gaspari S, Silvestri D, Russo B, Marino N, Ubezio P, Pagni F, Vergani P, Te Kronnie G, Valsecchi MG, Locatelli F, Rizzari C, Biondi A, Dander E, D'Amico G., Portale, F, Cricrì, G, Bresolin, S, Lupi, M, Gaspari, S, Silvestri, D, Russo, B, Marino, N, Ubezio, P, Pagni, F, Vergani, P, Te Kronnie, G, Valsecchi, M, Locatelli, F, Rizzari, C, Biondi, A, Dander, E, D'Amico, G, Portale F, Cricrì G, Bresolin S, Lupi M, Gaspari S, Silvestri D, Russo B, Marino N, Ubezio P, Pagni F, Vergani P, Te Kronnie G, Valsecchi MG, Locatelli F, Rizzari C, Biondi A, Dander E, and D'Amico G.
Abstract: B-cell precursor-acute lymphoblastic leukemia modulates the bone marrow (BM) niche to become leukemia-supporting and chemo-protective by reprogramming the stromal microenvironment. New therapies targeting the interplay between leukemia and stroma can help improve disease outcome. We identified ActivinA, a TGF-b family member with a well-described role in promoting several solid malignancies, as a factor favoring leukemia that could represent a new potential target for therapy. ActivinA resulted over-expressed in the leukemic BM and its production was strongly induced in mesenchymal stromal cells after culture with leukemic cells. Moreover, MSCs isolated from BM of leukemic patients showed an intrinsic ability to secrete higher amounts of ActivinA compared to their normal counterparts. The pro-inflammatory leukemic BM microenvironment synergized with leukemic cells to induce stromal-derived ActivinA. Gene expression analysis of ActivinA-treated leukemic cells showed that this protein was able to significantly influence motility-associated pathways. Interestingly, ActivinA promoted random motility and CXCL12-driven migration of leukemic cells, even at suboptimal chemokine concentrations, characterizing the leukemic niche. Conversely, ActivinA severely impaired CXCL12-induced migration of healthy CD34 + cells. This opposite effect can be explained by the ability of ActivinA to increase intracellular calcium only in leukemic cells, boosting cytoskeleton dynamics through a higher rate of actin polymerization. Moreover, by stimulating the invasiveness of the leukemic cells, ActivinA was found to be a leukemia-promoting factor. Importantly, the ability of ActivinA to enhance BM engraftment and the metastatic potential of leukemic cells was confirmed in a xenograft mouse model of the disease. Overall, ActivinA was seen to be a key factor in conferring a migratory advantage to leukemic cells over healthy hematopoiesis within the leukemic niche.
Published: 2019

31. Results of a Multicentre, Randomized, Controlled Open-Label Study on the Use of Anti-T-Lymphocyte Globulin (ATLG) and Rituximab for Immunomodulation of Graft-Versus-Host Disease (GvHD) and Graft Failure (GF) in Patients with Non-Malignant Disorders.

Author: Algeri, M, Galimberti, S, Bernardo, M, Rovelli, A, Zecca, M, La Nasa, G, Marktel, S, Merli, P, Bertaina, A, Pagliara, D, Boccieri, E, Del Bufalo, F, Gaspari, S, Ruggeri, A, Capitoli, G, Valsecchi, M, Locatelli, F, Bernardo, ME, Valsecchi, MG, Algeri, M, Galimberti, S, Bernardo, M, Rovelli, A, Zecca, M, La Nasa, G, Marktel, S, Merli, P, Bertaina, A, Pagliara, D, Boccieri, E, Del Bufalo, F, Gaspari, S, Ruggeri, A, Capitoli, G, Valsecchi, M, Locatelli, F, Bernardo, ME, and Valsecchi, MG
Published: 2019

32. New approaches for the validation of a highly skewed surrogate for a survival endpoint

Author: Galimberti, S, Capitoli, G, Rotolo, F, Valsecchi, M, Valsecchi, MG, Galimberti, S, Capitoli, G, Rotolo, F, Valsecchi, M, and Valsecchi, MG
Published: 2019

33. The validation of a highly skewed surrogate for a survival endpoint: new approaches

Author: Capitoli, G, Rotolo, F, Rebora, P, Valsecchi, M, Galimberti, S, Valsecchi, MG, Capitoli, G, Rotolo, F, Rebora, P, Valsecchi, M, Galimberti, S, and Valsecchi, MG
Published: 2019

34. Patients' and physicians' interpretation of chemotherapy-induced peripheral neurotoxicity

Author: Cavaletti, G, Cornblath, Dr, Merkies, Isj, Postma, Tj, Rossi, E, Alberti, P, Bruna, J, Argyriou, Aa, Briani, C, Velasco, R, Kalofonos, Hp, Psimaras, D, Ricard, D, Pace, A, Faber, Cg, Lalisang, Ri, Brandsma, D, Koeppen, S, Kerrigan, S, Schenone, A, Grisold, W, Mazzeo, A, Padua, Luca, Dorsey, Sg, Penas-Prado, M, Valsecchi, Mg, Padua L (ORCID:0000-0003-2570-9326), Cavaletti, G, Cornblath, Dr, Merkies, Isj, Postma, Tj, Rossi, E, Alberti, P, Bruna, J, Argyriou, Aa, Briani, C, Velasco, R, Kalofonos, Hp, Psimaras, D, Ricard, D, Pace, A, Faber, Cg, Lalisang, Ri, Brandsma, D, Koeppen, S, Kerrigan, S, Schenone, A, Grisold, W, Mazzeo, A, Padua, Luca, Dorsey, Sg, Penas-Prado, M, Valsecchi, Mg, and Padua L (ORCID:0000-0003-2570-9326)
Abstract: To test if and how chemotherapy-induced peripheral neurotoxicity (CIPN) is perceived differently by patients and physicians, making assessment and interpretation challenging. We performed a secondary analysis of the CI-PeriNomS study which included 281 patients with stable CIPN. We tested: (a) the association between patients' perception of activity limitation in performing eight common tasks and neurological impairment and (b) how the responses to questions related to these daily activities are interpreted by the treating oncologist. To achieve this, we compared patients' perception of their activity limitation with neurological assessment and the oncologists' blind interpretation. Distribution of the scores attributed by oncologists to each daily life maximum limitation ("impossible") generated three groups: Group 1 included limitations oncologists attributed mainly to motor impairment; Group 2 ones mainly attributed to sensory impairment and Group 3 ones with uncertain motor and sensory impairment. Only a subset of questions showed a significant trend between severity in subjective limitation, reported by patients, and neurological impairment. In Group 1, neurological examination confirmed motor impairment in only 51%-65% of patients; 76%-78% of them also had vibration perception impairment. In Group 2, sensory impairment ranged from 84% to 100%; some degree of motor impairment occurred in 43%-56% of them. In Group 3 strength reduction was observed in 49%-50% and sensory perception was altered in up to 82%. Interpretation provided by the panel of experienced oncologists was inconsistent with the neurological impairment. These observations highlight the need of a core set of outcome measures for future CIPN trials.
Published: 2019

35. Soluble CD163 and mannose receptor as markers of liver disease severity and long term prognosis in patients with primary biliary cholangitis

Author: Bossen, L, Rebora, P, Bernuzzi, F, Aloise, C, Jepsen, P, Gerussi, A, Moller, H, Valsecchi, M, Carbone, M, Gronbæk, H, Invernizzi, P, Moller, HJ, Valsecchi, MG, Bossen, L, Rebora, P, Bernuzzi, F, Aloise, C, Jepsen, P, Gerussi, A, Moller, H, Valsecchi, M, Carbone, M, Gronbæk, H, Invernizzi, P, Moller, HJ, and Valsecchi, MG
Published: 2019

36. Prospective Study on Allogeneic Bone Marrow Transplantation (Allo BMT) versus Chemotherapy (Chemo) for Very High-Risk (VHR) Childhood Acute Lymphoblastic Leukaemia in First Complete Remission

Author: Uderzo, C, Balduzzi, A, De Lorenzo, P, Valsecchi, MG, Gadner, H, Klingebiel, T, Zimmermann, M, and Schrappe, M
Published: 2001
Full Text: View/download PDF

37. Methods for the validation of a highly skewed continuous surrogate endpoint for a time to event endpoint

Author: Capitoli, G, Rotolo, F, Valsecchi, MG, Galimberti, S, Capitoli, G, Rotolo, F, Valsecchi, M, and Galimberti, S
Subjects: Acute lymphoblatic leukaemia, Minimal Residual Disease (MRD), Highly skewed distribution, Surrogate endpoints, Copula models
Published: 2018

38. Development of new methods for the validation of non standard distributions for the surrogate endpoint for a time to event endpoint

Author: Capitoli, G, Rotolo, F, PACIFICO, CLAUDIA, Valsecchi, MG, Galimberti, S, Capitoli, G, Rotolo, F, Pacifico, C, Valsecchi, M, and Galimberti, S
Subjects: Copula model, Surrogate endpoint, acute lymphoblastic leukaemia, Minimal residual disease (MRD), highly skewed distribution
Published: 2018

39. Assessing the effect of a partly unobserved, exogenous, binary time-dependent covariate on survival probabilities using generalised pseudo-values

Author: Pötschger, U, Heinzl, H, Valsecchi, M, Mittlböck, M, Valsecchi, MG, Pötschger, U, Heinzl, H, Valsecchi, M, Mittlböck, M, and Valsecchi, MG
Abstract: Background: Investigating the impact of a time-dependent intervention on the probability of long-term survival is statistically challenging. A typical example is stem-cell transplantation performed after successful donor identification from registered donors. Here, a suggested simple analysis based on the exogenous donor availability status according to registered donors would allow the estimation and comparison of survival probabilities. As donor search is usually ceased after a patient's event, donor availability status is incompletely observed, so that this simple comparison is not possible and the waiting time to donor identification needs to be addressed in the analysis to avoid bias. It is methodologically unclear, how to directly address cumulative long-term treatment effects without relying on proportional hazards while avoiding waiting time bias. Methods: The pseudo-value regression technique is able to handle the first two issues; a novel generalisation of this technique also avoids waiting time bias. Inverse-probability-of-censoring weighting is used to account for the partly unobserved exogenous covariate donor availability. Results: Simulation studies demonstrate unbiasedness and satisfying coverage probabilities of the new method. A real data example demonstrates that study results based on generalised pseudo-values have a clear medical interpretation which supports the clinical decision making process. Conclusions: The proposed generalisation of the pseudo-value regression technique enables to compare survival probabilities between two independent groups where group membership becomes known over time and remains partly unknown. Hence, cumulative long-term treatment effects are directly addressed without relying on proportional hazards while avoiding waiting time bias.
Published: 2018

40. Non-parametric estimation of survival probabilities with a time-dependent exposure switch: Application to (simulated) heart transplant data

Author: Bernasconi, D, Valsecchi, M, Antolini, L, Bernasconi, DP, Valsecchi, MG, Bernasconi, D, Valsecchi, M, Antolini, L, Bernasconi, DP, and Valsecchi, MG
Abstract: Background: To summarize the survival experience of patients waiting for heart transplant and to compare it with the post-transplant survival it is not possible to use the Kaplan-Meier estimator considering the intervention status as fixed in time because of the well known “immortal time bias” issue. Methods: We reviewed and applied to a simulated dataset the available methods to perform a non-parametric analysis accounting for the time-varying nature of the transplant status. Specifically we considered the Simon-Makuch estimator and the recently proposed “clock-back” estimator. Results: We showed that the Simon-Makuch estimator for the survival of patients on list is unbiased but the corresponding estimator of the post-transplant survival is not reliable for non-markov contexts like the one considered. Instead, if the semi-Markov assumption could be postulated (the post-transplant mortality depends mainly on the time since transplant and not on the waiting time to the intervention), the "clock-back" estimator produces valid results. Conclusion: We enlightened the importance of testing the process memory assumptions (e.g. Markov properties) in order to choose the approach more reliable. Moreover, we recommend the use of the Simon-Makuch method to study the survival of patients before the intervention and the use of the "clock back" estimator for the post-intervention survival in semi-markovian contexts.
Published: 2018

41. The presence of mutated and deleted PTEN is associated with an increased risk of relapse in childhood T cell acute lymphoblastic leukaemia treated with AIEOP-BFM ALL protocols

Author: Paganin, M, Grillo, M, Silvestri, D, Scapinello, G, Buldini, B, Cazzaniga, G, Biondi, A, Valsecchi, M, Conter, V, Te Kronnie, G, Basso, G, Grillo, MF, Valsecchi, MG, Paganin, M, Grillo, M, Silvestri, D, Scapinello, G, Buldini, B, Cazzaniga, G, Biondi, A, Valsecchi, M, Conter, V, Te Kronnie, G, Basso, G, Grillo, MF, and Valsecchi, MG
Abstract: Notwithstanding the improvement in treatment results for paediatric T cell acute lymphoblastic leukaemia (T-ALL) it remains important to understand if genetic aberrations influence therapy response. PTEN tumour suppressor gene inactivation is a frequent event in T-ALL but its effect on patient therapy response is debatable. We analysed the effect of the presence of mutated PTEN on outcome in 257 children with T-ALL treated with Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)-Berlin-Frankfürt-Münster (BFM) protocols. PTEN mutations were present in 31 (12·1%) patients and were significantly associated with increased risk of relapse. PTEN mutations also indicate a poor prognosis in T-ALL patients in the absence of NOTCH1 mutations or in the group of patients with co-presence of PTEN mutation and deletions. These results indicate that PTEN genomic aberrations and the biologically consequential PTEN inactivation contribute to adverse therapy response in T-ALL patients; PTEN status as a biomarker may contribute to the development of new molecularly-defined stratification algorithms
Published: 2018

42. Risk stratification of oxaliplatin induced peripheral neurotoxicity applying electrophysiological testing of dorsal sural nerve

Author: Alberti, P, Rossi, E, Argyriou, A, Kalofonos, H, Briani, C, Cacciavillani, M, Campagnolo, M, Bruna, J, Velasco, R, Cazzaniga, M, Cortinovis, D, Valsecchi., M, Cavaletti, G, Argyriou, AA, Kalofonos, HP, Cazzaniga, ME, Valsecchi. MG, Alberti, P, Rossi, E, Argyriou, A, Kalofonos, H, Briani, C, Cacciavillani, M, Campagnolo, M, Bruna, J, Velasco, R, Cazzaniga, M, Cortinovis, D, Valsecchi., M, Cavaletti, G, Argyriou, AA, Kalofonos, HP, Cazzaniga, ME, and Valsecchi. MG
Abstract: Purpose: We aimed to verify the predictiveness of dorsal sural nerve neurophysiological monitoring in obtaining risk stratification for oxaliplatin-induced peripheral neurotoxicity (OXAPN). Methods: We conducted a secondary analysis on a cohort of 110 colorectal cancer patients who were evaluated clinically and neurophysiologically before chemotherapy, at mid-treatment and at discontinuation. We applied the classification tree analysis method to predict the end-of-treatment OXAPN neurophysiological diagnosis, using data recorded at mid-treatment. We then ascertained the correlation between the obtained classes and neurological impairment at the end of treatment (Fisher’s exact test). Results: Dorsal sural nerve monitoring enabled us to stratify oxaliplatin-treated patients into risk classes with an implemented approach to neurophysiology application in this setting. Neurological outcome at discontinuation was predicted by neurophysiological monitoring performed during chemotherapy administration. Conclusions: We demonstrated the role that neurophysiology may play in clinical trials as an early surrogate marker that can predict OXAPN development at the end of treatment. Specifically, we propose abnormal dorsal sural sensory nerve testing as an early biomarker in identifying patients at high risk of eventually developing OXAPN.
Published: 2018

43. NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL

Author: Prieto, C, Lopez-Millan, B, Roca-Ho, H, Stam, Ronald, Romero-Moya, D, Rodriguez-Baena, FJ, Sanjuan-Pla, A, Ayllon, V, Ramirez, M, Bardini, M, de Lorenzo, P, Valsecchi, MG, Stanulla, M, Iglesias, M, Ballerini, P, Carcaboso, AM, Mora, J, Locatelli, F (Franco), Bertaina, A, Padilla, L, Rodriguez-Manzaneque, JC, Buen, C, Menendez, P, Prieto, C, Lopez-Millan, B, Roca-Ho, H, Stam, Ronald, Romero-Moya, D, Rodriguez-Baena, FJ, Sanjuan-Pla, A, Ayllon, V, Ramirez, M, Bardini, M, de Lorenzo, P, Valsecchi, MG, Stanulla, M, Iglesias, M, Ballerini, P, Carcaboso, AM, Mora, J, Locatelli, F (Franco), Bertaina, A, Padilla, L, Rodriguez-Manzaneque, JC, Buen, C, and Menendez, P
Published: 2018

44. Efficacy and safety of extracranial vein angioplasty in multiple sclerosis: A randomized clinical trial

Author: Zamboni, P, Tesio, L, Galimberti, S, Massacesi, L, Salvi, F, D'Alessandro, R, Cenni, P, Galeotti, R, Papini, D, D'Amico, R, Simi, S, Valsecchi, M, Filippini, G, Valsecchi, MG, Zamboni, P, Tesio, L, Galimberti, S, Massacesi, L, Salvi, F, D'Alessandro, R, Cenni, P, Galeotti, R, Papini, D, D'Amico, R, Simi, S, Valsecchi, M, Filippini, G, and Valsecchi, MG
Abstract: Importance: Chronic cerebrospinal venous insufficiency (CCSVI) is characterized by restricted venous outflow from the brain and spinal cord. Whether this condition is associated with multiple sclerosis (MS) and whether venous percutaneous transluminal angioplasty (PTA) is beneficial in persons with MS and CCSVI is controversial. Objective: To determine the efficacy and safety of venous PTA in patients with MS and CCSVI. Design, Setting, and Participants: We analyzed 177 patients with relapsing-remitting MS; 62 were ineligible, including 47 (26.6%) who did not have CCSVI on color Doppler ultrasonography screening. A total of 115 patients were recruited in the study timeframe. All patients underwent a randomized, double-blind, sham-controlled, parallel-group trial in 6MS centers in Italy. The trial began in August 2012 and concluded in March 2016; data were analyzed from April 2016 to September 2016. The analysis was intention to treat. Interventions: Patients were randomly allocated (2:1) to either venous PTA or catheter venography without venous angioplasty (sham). Main Outcomes and Measures: Two primary end pointswere assessed at 12 months: (1) a composite functional measure (ie, walking control, balance, manual dexterity, postvoid residual urine volume, and visual acuity) and (2) a measure of new combined brain lesions on magnetic resonance imaging, including the proportion of lesion-free patients. Combined lesions included T1 gadolinium-enhancing lesions plus new or enlarged T2 lesions. Results: Of the included 115 patients with relapsing-remitting MS, 76 were allocated to the PTA group (45 female [59%]; mean [SD] age, 40.0 [10.3] years) and 39 to the sham group (29 female [74%]; mean [SD] age, 37.5 [10.6] years); 112 (97.4%) completed follow-up. No serious adverse events occurred. Flow restoration was achieved in 38 of 71 patients (54%) in the PTA group. The functional composite measure did not differ between the PTA and sham groups (41.7%vs 48.7%; odds ratio, 0
Published: 2018

45. Predictive value of minimal residual disease in philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies

Author: Cazzaniga, G, De Lorenzo, P, Alten, J, Röttgers, S, Hancock, J, Saha, V, Castor, A, Madsen, H, Gandemer, V, Cavé, H, Leoni, V, Köhler, R, Ferrari, G, Bleckmann, K, Pieters, R, Van Der Velden, V, Stary, J, Zuna, J, Escherich, G, Stadt, U, Aricò, M, Conter, V, Schrappe, M, Valsecchi, M, Biondi, A, Röttgers, Si, Madsen, HO, Ferrari, GM, Stadt, UZ, Conter, Valentino, Valsecchi, MG, Cazzaniga, G, De Lorenzo, P, Alten, J, Röttgers, S, Hancock, J, Saha, V, Castor, A, Madsen, H, Gandemer, V, Cavé, H, Leoni, V, Köhler, R, Ferrari, G, Bleckmann, K, Pieters, R, Van Der Velden, V, Stary, J, Zuna, J, Escherich, G, Stadt, U, Aricò, M, Conter, V, Schrappe, M, Valsecchi, M, Biondi, A, Röttgers, Si, Madsen, HO, Ferrari, GM, Stadt, UZ, Conter, Valentino, and Valsecchi, MG
Abstract: The prognostic value of minimal residual disease (MRD) in Philadelphia-chromosome-positive (Ph+) childhood acute lymphoblastic leukemia (ALL) treated with tyrosine kinase inhibitors is not fully established. We detected MRD by real-time quantitative polymerase chain reaction (RQ-PCR) of rearranged immunoglobulin/T-cell receptor genes (IG/TR) and/or BCR/ABL1 fusion transcript to investigate its predictive value in patients receiving Berlin-Frankfurt-MÃ1⁄4nster (BFM) high-risk (HR) therapy and post-induction intermittent imatinib (the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia (EsPhALL) study). MRD was monitored after induction (time point (TP)1), consolidation Phase IB (TP2), HR Blocks, reinductions, and at the end of therapy. MRD negativity progressively increased over time, both by IG/TR and BCR/ABL1. Of 90 patients with IG/TR MRD at TP1, nine were negative and none relapsed, while 11 with MRD<5Ã10â4and 70 with MRDâ¥5Ã10â4had a comparable 5-year cumulative incidence of relapse of 36.4 (15.4) and 35.2 (5.9), respectively. Patients who achieved MRD negativity at TP2 had a low relapse risk (5-yr cumulative incidence of relapse (CIR)=14.3[9.8]), whereas those who attained MRD negativity at a later date showed higher CIR, comparable to patients with positive MRD at any level. BCR/ABL1 MRD negative patients at TP1 had a relapse risk similar to those who were IG/TR MRD negative (1/8 relapses). The overall concordance between the two methods is 69%, with significantly higher positivity by BCR/ABL1. In conclusion, MRD monitoring by both methods may be functional not only for measuring response but also for guiding biological studies aimed at investigating causes for discrepancies, although from our data IG/TR MRD monitoring appears to be more reliable. Early MRD negativity is highly predictive of favorable outcome. The earlier MRD negativity is achieved, the better the prognosis.
Published: 2018

46. Reduced-Intensity delayed intensification in standard-Risk pediatric acute lymphoblastic leukemia defined by undetectable minimal residual disease: Results of an international randomized trial (AIEOP-BFM ALL 2000)

Author: Schrappe, M, Bleckmann, K, Zimmermann, M, Biondi, A, Möricke, A, Locatelli, F, Cario, G, Rizzari, C, Attarbaschi, A, Valsecchi, M, Bartram, C, Barisone, E, Niggli, F, Niemeyer, C, Testi, A, Mann, G, Ziino, O, Schäfer, B, Panzer-Grümayer, R, Beier, R, Parasole, R, Göhring, G, Ludwig, W, Casale, F, Schlegel, P, Basso, G, Conter, V, Valsecchi, MG, Bartram, CR, Testi, AM, Ludwig, WD, Schlegel, PG, Schrappe, M, Bleckmann, K, Zimmermann, M, Biondi, A, Möricke, A, Locatelli, F, Cario, G, Rizzari, C, Attarbaschi, A, Valsecchi, M, Bartram, C, Barisone, E, Niggli, F, Niemeyer, C, Testi, A, Mann, G, Ziino, O, Schäfer, B, Panzer-Grümayer, R, Beier, R, Parasole, R, Göhring, G, Ludwig, W, Casale, F, Schlegel, P, Basso, G, Conter, V, Valsecchi, MG, Bartram, CR, Testi, AM, Ludwig, WD, and Schlegel, PG
Abstract: Purpose Delayed intensification (DI) is an integral part of treatment of childhood acute lymphoblastic leukemia (ALL), but it is associated with relevant toxicity. Therefore, standard-risk patients of trial AIEOP-BFM ALL 2000 (Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With ALL) were investigated with the specific aim to reduce treatment intensity. Patients and Methods Between July 2000 and July 2006, 1,164 patients (1 to 17 years of age) with standard-risk ALL (defined as the absence of high-risk cytogenetics and undetectable minimal residual disease on days 33 and 78) were randomly assigned to either experimental reduced-intensity DI (protocol III; P-III) or standard DI (protocol II; P-II). Cumulative drug doses of P-III were reduced by 30% for dexamethasone and 50% for vincristine, doxorubicin, and cyclophosphamide, which shortened the treatment duration from 49 to 29 days. The study aimed at noninferiority of reduced-intensity P-III; analyses were performed according to treatment given. Results For P-III and P-II, respectively, the 8-year rate of disease-free survival (6 SE) was 89.2 6 1.3% and 92.3 6 1.2% (P = .04); cumulative incidence of relapse, 8.7 6 1.2% and 6.4 6 1.1% (P = .09); and overall survival, 96.1 6 0.8% and 98.0 6 0.6% (P = .06). Patients with ETV6-RUNX1âpositive ALL and patients 1 to 6 years of age performed equally well in both arms. The incidence of death during remission was comparable, which indicates equivalent toxicity. The 8-year cumulative incidence rate of secondary malignancies was 1.3 6 0.5% and 0.6 6 0.4% for P-III and P-II, respectively (P = .37). Conclusion Although the criteria used for the standard-risk definition in this trial identified patients with exceptionally good prognosis, reduction of chemotherapy was not successful mainly because of an increased rate of relapse. The data suggest that treatment reduction is feasible in specific subgroups, which underlines the biologic heterogeneity o
Published: 2018

47. Preoperative Oral Carbohydrate Load Versus Placebo in Major Elective Abdominal Surgery (PROCY): A Randomized, Placebo-controlled, Multicenter, Phase III Trial

Author: Gianotti, L, Biffi, R, Sandini, M, Marrelli, D, Vignali, A, Caccialanza, R, Viganò, J, Sabbatini, A, Di Mare, G, Alessiani, M, Antomarchi, F, Valsecchi, M, Bernasconi, D, Valsecchi, MG, Bernasconi, DP, Gianotti, L, Biffi, R, Sandini, M, Marrelli, D, Vignali, A, Caccialanza, R, Viganò, J, Sabbatini, A, Di Mare, G, Alessiani, M, Antomarchi, F, Valsecchi, M, Bernasconi, D, Valsecchi, MG, and Bernasconi, DP
Abstract: OBJECTIVE:: To explore whether preoperative oral carbohydrate (CHO) loading could achieve a reduction in the occurrence of postoperative infections. BACKGROUND:: Hyperglycemia may increase the risk of infection. Preoperative CHO loading can achieve postoperative glycemic control. METHODS:: This was a randomized, controlled, multicenter, open-label trial. Nondiabetic adult patients who were candidates for elective major abdominal operation were randomized (1:1) to a CHO (preoperative oral intake of 800?mL of water containing 100?g of CHO) or placebo group (intake of 800?mL of water). The blood glucose level was measured every 4?hours for 4 days. Insulin was administered when the blood glucose level was >180?mg/dL. The primary endpoint was the occurrence of postoperative infection. The secondary endpoint was the number of patients needing insulin. RESULTS:: From January 2011 through December 2015, 880 patients were randomly allocated to the CHO (n = 438) or placebo (n = 442) group. From each group, 331 patients were available for the analysis. Postoperative infection occurred in 16.3% (54/331) of CHO group patients and 16.0% (53/331) of placebo group patients (relative risk 1.019, 95% confidence interval 0.720â1.442, P = 1.00). Insulin was needed in 8 (2.4%) CHO group patients and 53 (16.0%) placebo group patients (relative risk 0.15, 95% confidence interval 0.07â0.31, P < 0.001). CONCLUSIONS:: Oral preoperative CHO load is effective for avoiding a blood glucose level >180?mg/dL, but without affecting the risk of postoperative infectious complication
Published: 2018

48. Marriage and parenthood among subjects cured of childhood cancer: a report from the Italian AIEOP Off-Therapy Registry

Author: Pivetta, EMANUELE EMILIO, Maule, MILENA MARIA, Pisani, Paola, Zugna, Daniela, Haupt, R, Jankovic, M, Arico', M, Casale, F, Clerico, A, CORDERO DI MONTEZEMOLO, Luca, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, Mg, Dama, Elisa, Magnani, C, Merletti, Franco, Pastore, G., Pivetta E., Maule MM., Pisani P., Zugna D., Haupt R., Jankovic M., Arico' M., Casale F., Clerico A., Cordero di Montezemolo L., Kiren V., Locatelli F., Palumbo G., Pession A., Pillon M., Santoro N., Terenziani M., Valsecchi MG., Dama E., Magnani C., Merletti F., Pastore G., Pivetta, E, Maule, Mm, Pisani, P, Zugna, D, Haupt, R, Jankovic, M, Aricò, M, Casale, Fiorina, Clerico, A, CORDERO DI MONTEZEMOLO, L, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, Mg, Dama, E, Magnani, C, Merletti, F, and Pastore, G.
Subjects: Quality of life, Fertility, childhood cancer, Marriage, Long-term survivors, childhood cancer, marriage, fertility, long-term survivors, quality of life
Abstract: The aim of this study was to describe the patterns of marriage and parenthood in a cohort of childhood cancer survivors included in the Off-Therapy Registry maintained by the Italian Association of Pediatric Hematology and Oncology. Design and Methods We analyzed a cohort of 6,044 patients diagnosed with cancer between 1960 and 1998, while aged 0 to 14 years and who were 18 years old or older by December 2003. They were followed up through the regional vital statistics registers until death or the end of follow up (October 30, 2006), whichever occurred first, and their marital status and date of birth of their children were recorded. The cumulative probabilities of being married and having a first child were computed by gender and compared by tumor type within the cohort. Marriage and fertility rates (the latter defined as the number of live births per woman-year) were compared with those of the Italian population of the same age, gender, area of residence and calendar period by means of the observed to expected (O/E) ratios. Results During the follow-up period, 4,633 (77%) subjects had not married. The marriage O/E ratios were 0.56 (95% CI: 0.51-0.61) and 0.70 (95% CI: 0.65-0.76) among men and women, respectively. Overall, 263 men had 367 liveborn children, and 473 women had 697 liveborn children. The female fertility O/E ratio was 0.57 (95% CI: 0.53-0.62) overall, and 1.08 (95% CI: 0.99-1.17) when analyses were restricted to married/cohabiting women Conclusions Childhood cancer survivors are less likely to marry and to have children than the general population, confirming the life-long impact of their previous disease on their social behavior and choices. The inclusion of counseling in the strategies of management and long-term surveillance of childhood cancer patients could be beneficial to survivors as they approach adulthood.
Published: 2011

49. Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster

Author: Cazzaniga, G, Bisanti, L, Randi, G, Deandrea, S, Bungaro, S, Pregliasco, F, Perotti, D, Spreafico, F, Masera, G, Valsecchi, M, Biondi, A, Greaves, M, Valsecchi, MG, Cazzaniga, G, Bisanti, L, Randi, G, Deandrea, S, Bungaro, S, Pregliasco, F, Perotti, D, Spreafico, F, Masera, G, Valsecchi, M, Biondi, A, Greaves, M, and Valsecchi, MG
Published: 2017

50. Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I

Author: Azario, I, Pievani, A, Del Priore, F, Antolini, L, Santi, L, Corsi, A, Cardinale, L, Sawamoto, K, Kubaski, F, Gentner, B, Bernardo, M, Valsecchi, M, Riminucci, M, Tomatsu, S, Aiuti, A, Biondi, A, Serafini, M, SANTI, LUDOVICA, Bernardo, ME, Valsecchi, MG, Azario, I, Pievani, A, Del Priore, F, Antolini, L, Santi, L, Corsi, A, Cardinale, L, Sawamoto, K, Kubaski, F, Gentner, B, Bernardo, M, Valsecchi, M, Riminucci, M, Tomatsu, S, Aiuti, A, Biondi, A, Serafini, M, SANTI, LUDOVICA, Bernardo, ME, and Valsecchi, MG
Abstract: Umbilical cord blood (UCB) is a promising source of stem cells to use in early haematopoietic stem cell transplantation (HSCT) approaches for several genetic diseases that can be diagnosed at birth. Mucopolysaccharidosis type I (MPS-I) is a progressive multi-system disorder caused by deficiency of lysosomal enzyme Î±-L-iduronidase, and patients treated with allogeneic HSCT at the onset have improved outcome, suggesting to administer such therapy as early as possible. Given that the best characterized MPS-I murine model is an immunocompetent mouse, we here developed a transplantation system based on murine UCB. With the final aim of testing the therapeutic efficacy of UCB in MPS-I mice transplanted at birth, we first defined the features of murine UCB cells and demonstrated that they are capable of multi-lineage haematopoietic repopulation of myeloablated adult mice similarly to bone marrow cells. We then assessed the effectiveness of murine UCB cells transplantation in busulfan-conditioned newborn MPS-I mice. Twenty weeks after treatment, iduronidase activity was increased in visceral organs of MPS-I animals, glycosaminoglycans storage was reduced, and skeletal phenotype was ameliorated. This study explores a potential therapy for MPS-I at a very early stage in life and represents a novel model to test UCB-based transplantation approaches for various diseases.
Published: 2017

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

578 results on '"Valsecchi. MG"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources