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411 results on '"Valmori, Danila"'

1. Consensus nomenclature for CD8+ T cell phenotypes in cancer

Author

Apetoh, Lionel, Smyth, Mark J, Drake, Charles G, Abastado, Jean-Pierre, Apte, Ron N, Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H, Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P, Comin-Anduix, Begoña, Coukos, Georges, Dhodapkar, Madhav V, Dranoff, Glenn, Frazer, Ian H, Fridman, Wolf-Hervé, Gabrilovich, Dmitry I, Gilboa, Eli, Gnjatic, Sacha, Jäger, Dirk, Kalinski, Pawel, Kaufman, Howard L, Kiessling, Rolf, Kirkwood, John, Knuth, Alexander, Liblau, Roland, Lotze, Michael T, Lugli, Enrico, Marincola, Francesco, Melero, Ignacio, Melief, Cornelis J, Mempel, Thorsten R, Mittendorf, Elizabeth A, Odun, Kunle, Overwijk, Willem W, Palucka, Anna Karolina, Parmiani, Giorgio, Ribas, Antoni, Romero, Pedro, Schreiber, Robert D, Schuler, Gerold, Srivastava, Pramod K, Tartour, Eric, Valmori, Danila, van der Burg, Sjoerd H, van der Bruggen, Pierre, van den Eynde, Benoît J, Wang, Ena, Zou, Weiping, Whiteside, Theresa L, Speiser, Daniel E, Pardoll, Drew M, Restifo, Nicholas P, and Anderson, Ana C

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, 2.1 Biological and endogenous factors, Aetiology, anergy, anticancer immunity, CD8(+) T cells, cytotoxicity, exhaustion, effector, IFN gamma, senescence, stemness, CD8+ T cells, IFNγ, Oncology and carcinogenesis
Abstract

Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T cells in cancer calls for a more precise definition of the CD8+ T cell immune phenotypes in cancer and the abandonment of the generic terms "pro-tumor" and "antitumor." Based on recent studies investigating the functions of CD8+ T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8+ T cells in cancer.

Published
2015

10. Supplementary Figure 1 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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11. Supplementary Methods from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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12. Supplementary Figure 1 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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13. Supplementary Table 1 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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15. Supplementary Figure Legend from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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16. Supplementary Table 2 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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17. Data from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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18. Supplementary Figure Legend from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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19. Supplementary Figure 5 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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20. Supplementary Figure 3 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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21. Data from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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26. Supplementary Figure 4 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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27. Supplementary Figure 6 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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28. Supplementary Figure 1 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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29. Supplementary Figure 5 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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30. Supplementary Table 1 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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32. Supplementary Figure 4 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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33. Supplementary Figure 2 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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35. Supplementary Figure 2 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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36. Supplementary Figure 3 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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38. Supplementary Materials, Legends for Figures 1-5 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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40. Phase I/II Multicenter Trial of a Novel Therapeutic Cancer Vaccine, HepaVac-101, for Hepatocellular Carcinoma

Author

Löffler, Markus W., primary, Gori, Stefania, additional, Izzo, Francesco, additional, Mayer-Mokler, Andrea, additional, Ascierto, Paolo A., additional, Königsrainer, Alfred, additional, Ma, Yuk Ting, additional, Sangro, Bruno, additional, Francque, Sven, additional, Vonghia, Luisa, additional, Inno, Alessandro, additional, Avallone, Antonio, additional, Ludwig, Jörg, additional, Alcoba, Diego Duarte, additional, Flohr, Christian, additional, Aslan, Katrin, additional, Mendrzyk, Regina, additional, Schuster, Heiko, additional, Borrelli, Marco, additional, Valmori, Danila, additional, Chaumette, Tanguy, additional, Heidenreich, Regina, additional, Gouttefangeas, Cécile, additional, Forlani, Greta, additional, Tagliamonte, Maria, additional, Fusco, Caterina, additional, Penta, Roberta, additional, Iñarrairaegui, Mercedes, additional, Gnad-Vogt, Ulrike, additional, Reinhardt, Carsten, additional, Weinschenk, Toni, additional, Accolla, Roberto S., additional, Singh-Jasuja, Harpreet, additional, Rammensee, Hans-Georg, additional, and Buonaguro, Luigi, additional

Published
2022
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44. Vaccination with NY-ESO-1 Protein and CpG in Montanide Induces Integrated Antibody/Th1 Responses and CD8 T Cells through Cross-Priming

Author

Valmori, Danila, Souleimanian, Naira E., Tosello, Valeria, Bhardwaj, Nina, Adams, Sylvia, O'Neill, David, Pavlick, Anna, Escalon, Juliet B., Cruz, Crystal M., Angiulli, Angelica, Angiulli, Francesca, Mears, Gregory, Vogel, Susan M., Pan, Linda, Jungbluth, Achim A., Hoffmann, Eric W., Venhaus, Ralph, Ritter, Gerd, Old, Lloyd J., and Ayyoub, Maha

Published
2007
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46. Human [ROR[gamma]t.sup.+] [T.sub.H]17 cells preferentially differentiate from naive [FOXP3.sup.+]Treg in the presence of lineage-specific polarizing factors

Author

Valmori, Danila, Raffin, Caroline, Raimbaud, Isabelle, and Ayyoub, Maha

Subjects
T cells -- Properties, Transforming growth factors -- Research, Interleukins -- Properties, Autoimmunity -- Research, Science and technology
Abstract

[ROR[gamma]t.sup.+] [T.sub.H]17 cells are a proinflammatory [CD4.sup.+] T-cell population associated with autoimmune tissue injury. In mice, priming of [T.sub.H]17 requires TGF-[beta], which alone directs the priming of [FOXP3.sup.+] regulatory T cells (Treg), in association with inflammatory cytokines. Priming of human [T.sub.H]17 cells from conventional naive [CD4.sup.+] T cells under similar conditions, however, has proved difficult to achieve. Here, we report that differentiation of human [T.sub.H]17 cells preferentially occurs from [FOXP3.sup.+] naive Treg (NTreg) in the presence of IL-2 and IL-1[beta] and is increased by IL-23 and TGF-[beta]. IL-1[beta]-mediated differentiation correlated with IL-1RI expression in stimulated NTreg and was accompanied by induction of [ROR[gamma]t along with down-regulation of FOXP3. IL-17-secreting cells in NTreg cultures cosecreted TNF-[alpha] and IL-2 and contained distinct subpopulations cosecreting or not cosecreting IFN-[gamma] and other [T.sub.H]17-associated cytokines. Polarized NTreg contained significant subpopulations of CCR6-expressing cells that were highly enriched in IL-17-secreting cells. Finally, analysis of CCR6 expression with respect to that of IL-1RI identified distinct IL-17-secreting subpopulations that had maintained or lost their suppressive functions. Together our results support the concept that priming of human [T.sub.H]17 from naive [CD4.sup.+] T cells preferentially takes place from [FOXP3.sup.+] Treg precursors in the presence of lineage-specific polarizing factors. IL-1 | IL-17 | IL-23 | TGF-[beta] | CD4 T cells doi/ 10.1073/pnas.1008247107

Published
2010

47. Human memory [FOXP3.sup.+] Tregs secrete IL-17 ex vivo and constitutively express the [T.sub.H]17 lineage-specific transcription factor ROR[gamma]t

Author

Ayyoub, Maha, Deknuydt, Florence, Raimbaud, Isabelle, Dousset, Christelle, Leveque, Lucie, Bioley, Gilles, and Valmori, Danila

Subjects
DNA binding proteins -- Properties, Memory -- Physiological aspects, T cells -- Properties, Science and technology
Abstract

Recent studies have suggested a close relationship between [CD4.sup.+][FOXP3.sup.+] regulatory T cells (Tregs) and proinflammatory IL-17-producing T helper cells ([T.sub.H]17) expressing the lineage-specific transcription factor ROR[gamma]t. We report here the unexpected finding that human memory Tregs secrete IL-17 ex vivo and constitutively express ROR[gamma]t. IL-17-secreting Tregs share some phenotypic and functional features with conventional [T.sub.H]17 cells, expressing high levels of CCR4 and CCR6 and low levels of CXCR3. However, unlike conventional [T.sub.H]17 cells, they express low levels of CD161 and mostly fail to cosecrete IL-22 and TNF-[alpha] ex vivo. Ex vivo secretion of IL-17 and constitutive expression of ROR[gamma]t by human memory Tregs suggest that, in addition to their well-known suppressive functions, these cells likely play additional, as yet undescribed, proinflammatory functions.

Published
2009

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