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748 results on '"Valli, Ludovico"'

10. Tailoring Gold Nanoisland-Based Biosensors for Ultrasensitive Detection of Doxorubicin in Biological Fluids.

Author

Quarta, Alessandra, Bettini, Simona, Cuscunà, Massimo, Lorenzo, Daniela, Epifani, Gianmichele, Gigli, Giuseppe, Valli, Ludovico, Aliyev, Jamil A., Kazimov, Elkhan E., Bakhishova, Matanat J., Gasymov, Oktay K., and Simeone, Daniela

Abstract

Recent advancements in medical science have ushered in the era of "Personalized Medicine," which tailors treatments to individual genetics, lifestyle, and environmental factors. A cornerstone of this approach is continuous monitoring and adjustment of treatment regimens to optimize effectiveness while minimizing side effects. In therapeutic drug monitoring (TDM), crucial for drugs like doxorubicin (DOX) with severe side effects, traditional methods such as spectrofluorimetry and chromatography are utilized, but they suffer from cost and complexity issues. Biosensors, especially those leveraging Localized Surface Plasmon Resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS), offer a promising alternative. This study focuses on developing a cost-effective plasmonic biosensor using gold nanoislands semiembedded in a glass substrate. The LSPR platform, based on gold nanoislands (Au NIs) with an average diameter of 23 nm, offers a rapid method for ultrasensitive, label-free detection of DOX in biological fluids up to the nanomolar range, even in diluted (1:10) and undiluted blood serum samples from cancer patients receiving the drug. The method capitalizes on the extraordinary adhesion between the nanoislands and the glass matrix, preserving plasmon integrity while enhancing the electric field surrounding the nanoislands for improved sensitivity. Moreover, by exploiting nanoislands with Au/Al2O3 core/shell structures with an average diameter and gap of about 70 and 7 nm, respectively, highly efficient SERS-active platforms are created, enabling the detection of ultralow DOX concentrations down to picomolar range, where the LSPR system is insensitive. The combined use of both systems enables the detection of DOX across a broad range, from low to high nanomolar concentrations, in biological fluids. This integration of semiembedded nanoislands presents a scalable and multifunctional approach suitable for point-of-care diagnostics, offering reproducible and stable characteristics over time. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Chiral Recognition by Supramolecular Porphyrin–Hemicucurbit[8]uril-Functionalized Gravimetric Sensors

Author

Magna, Gabriele, primary, Šakarašvili, Marko, additional, Stefanelli, Manuela, additional, Giancane, Gabriele, additional, Bettini, Simona, additional, Valli, Ludovico, additional, Ustrnul, Lukas, additional, Borovkov, Victor, additional, Aav, Riina, additional, Monti, Donato, additional, Di Natale, Corrado, additional, and Paolesse, Roberto, additional

Published
2023
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39. Growth and characterization of films containing fullerenes and water soluble porphyrins for solar energy conversion applications

Author

Sgobba, Vito, Guldi, Dirk M., Giancane, Gabriele, Prato, Maurizio, Conoci, Sabrina, Valli, Ludovico, Casilli, Serena, and Ricciardi, Giampaolo

Subjects
Porphyrins -- Structure, Porphyrins -- Research, Solar energy -- Research, Chemistry
Abstract

Coulomb interactions are used between cationic fullerene derivatives at the water surface and anionic porphyrins dissolved in the water subphase to deposit monolayer dyad films. The films resulting from the interaction are transferred through the Langmuir-Schafer method, that is, horizontal lifting of the electrostatistically induced donor-acceptor systems.

Published
2007

40. Ethane-bridged zinc porphyrin dimers in Langmuir-Shafer thin films: Structural and spectroscopic properties

Author

Valli, Ludovico, Casilli, Serena, Giotta, Livia, Pignataro, Bruno, Conoci, Sabrina, Borovkov, Victor V., Inoue, Yoshihisa, and Sortino, Salvatore

Subjects
Porphyrins -- Optical properties, Dielectric films -- Optical properties, Thin films -- Optical properties, Zinc compounds -- Optical properties, Chemicals, plastics and rubber industries
Abstract

The structural and spectroscopic properties of ethane-bridged Zn porphyrin dimers in Langmuir-Schafer (LS) thin films are investigated. Diluting ethane-bridged Zn porphyrin dimers in arachidic acid minimizes the porphyrin aggregation and with ethane-bridged Zn porphyrin dimers exhibiting the anti conformation the LS films become photoresponsive, showing fluorescence emission and triplet-triplet transient absorption.

Published
2006

49. Sub‐ and Supramolecular X‐Ray Characterization of Engineered Tissues from Equine Tendon, Bovine Dermis, and Fish Skin Type‐I Collagen

Author

Terzi, Alberta, primary, Gallo, Nunzia, additional, Bettini, Simona, additional, Sibillano, Teresa, additional, Altamura, Davide, additional, Madaghiele, Marta, additional, De Caro, Liberato, additional, Valli, Ludovico, additional, Salvatore, Luca, additional, Sannino, Alessandro, additional, and Giannini, Cinzia, additional

Published
2020
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