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19 results on '"Valleri, Maurizio"'

3. Nonsteroidal Anti-Inflammatory Drugs–1-Phenylethylamine Diastereomeric Salts: A Systematic Solid-State Investigation

Author

Rossi, Patrizia, primary, Ceccarelli, Jacopo, additional, Milazzo, Stella, additional, Paoli, Paola, additional, Morais Missina, Juliana, additional, Ciattini, Samuele, additional, Ienco, Andrea, additional, Tuci, Giulia, additional, Valleri, Maurizio, additional, Giovannoni, Maria Paola, additional, Guerrini, Gabriella, additional, and Conti, Luca, additional

Published
2021
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12. Relationships between Anhydrous and Solvated Species of Dexketoprofen Trometamol: A Solid-State Point of View

Author

Rossi, Patrizia, Paoli, Paola, Chelazzi, Laura, Milazzo, Stella, Biagi, Diletta, Valleri, Maurizio, Ienco, Andrea, Valtancoli, Barbara, and Conti, Luca

Abstract

The three different solid forms of dexktoprofen trometamol (DK-T_A, DK-T_B, and DK-T_2H2O) have been studied by using X-ray diffraction and calorimetric methods. In the molecular and crystal structure of DK-T_A, the thermodynamically stable form used in the tablets production process, all the potential H-bond donors and acceptors of each trometamol cation are involved in strong H-bonds which hold together the cations as well as the dexketoprofen/trometamol ionic pairs. The dihydrate species is quickly formed starting from DK-T_Aapparently without the formation of an amorphous phase, and the process is fully reversible. In addition, the two solids have comparable crystal density (cell parameters and space group of the resulting hydrate were determined by X-ray powder diffraction). We speculate that the anhydrous and hydrate crystal architectures did not suffer upon the hydration/dehydration process and that the hydrate form belongs to the class of the channel hydrates and most probably is a planar hydrate. Finally, the unit cell parameters and space group were determined also for the metastable DK-T_Bsolid form.

Published
2020
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18. New solid self-microemulsifying systems to enhance dissolution rate of poorly water soluble drugs.

Author

Mura, Paola, Valleri, Maurizio, Cirri, Marzia, and Mennini, Natascia

Subjects
DRUG tablets, DRUG delivery systems, DRUG solubility testing, SOLID dosage forms, CHEMICAL stability, DRUG side effects, EXCIPIENTS
Abstract

Context: An adequate drug dissolution behavior is essential for the therapeutic effectiveness of all solid dosage forms. Objective: To develop a new solid self-micro-emulsifying drug delivery system (S-SMEDDS) to improve the dissolution properties of poorly water-soluble drugs, such as glyburide. Methods: Liquid self-micro-emulsifying drug delivery systems (SMEDDS) consisted of Labrafac-Hydro®, Tween® 20, Transcutol®, and drug. S-SMEDDS were prepared by adsorption of SMEDDS onto different adsorbents; the obtained powders were evaluated for flow, compactability and liquid-retention potential. The reconstitution ability of S-SMEDDS into SMEDDS by re-dispersion in water was assessed. Tablets, prepared by direct compression of selected S-SMEDDS, were characterized for technological properties and dissolution behavior. Results: Neusilin US2 was selected as the most effective adsorbent, based on its better flow and compacting properties, greater surface area and mesoporosity. The significantly higher ( P < 0.001) drug dissolution rate from S-SMEDDS-based tablets than from commercial tablets was ascribed to enhanced wetting and surface area of drug, finely distributed onto the hydrophilic adsorbent, and, above all, to the already drug dissolved form in the SMEDDS system. Properties, drug content and dissolution from S-SMEDDS tablets were unchanged after 25°C and 60% RH six-month storage. Conclusions: The developed tablets showed the advantages of SMEDDS, allowing a strong improvement of drug dissolution, together with increased physical and chemical stability. [ABSTRACT FROM AUTHOR]

Published
2012
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