17 results on '"Valle ED"'
Search Results
2. La responsabilità sciistica
- Author
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Valle (Ed.), Laura and Sesta (Ed.), Michele
- Published
- 2012
- Full Text
- View/download PDF
3. La lengua, ¿patria común? :$bideas e ideologías del español /$cJosé del Valle (ed.).
- Author
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José del Valle (ed.) and José del Valle (ed.)
- Subjects
- Language policy--Spain, Spanish language--Political aspects--Spain
- Abstract
¿Cuál es la naturaleza de las disputas en torno al estatus simbólico del español? Este libro aspira a responder parcialmente a esta pregunta a través del análisis tanto de las políticas contemporáneas orientadas a la difusión del idioma como de los discursos paralelos de legitimación. Desde el concepto de ideología lingüística y frente a los paradigmas del nacionalismo y la globalización, se analizan críticamente líneas de acción político-lingüística asociadas con instituciones tales como la RAE y el Instituto Cervantes: la afirmación del español como base de la hispanofonía, su diseño y explotación como activo económico, su difusión como lengua global y su aceptación en España como lengua común. Colaboran en este volumen José del Valle, Mauro Fernández, Laura Villa, Kathryn A. Woolard, Ángel López García y Luis Fernando Lara.
- Published
- 2007
4. Fabrication and Validation of Sub-Cellular Carbon Fiber Electrodes.
- Author
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Richie J, Letner JG, Mclane-Svoboda A, Huan Y, Ghaffari DH, Valle ED, Patel PR, Chiel HJ, Pelled G, Weiland JD, and Chestek CA
- Subjects
- Mice, Rats, Animals, Carbon Fiber, Electrodes, Implanted, Electrodes, Neurons physiology, Cerebral Cortex physiology
- Abstract
Multielectrode arrays for interfacing with neurons are of great interest for a wide range of medical applications. However, current electrodes cause damage over time. Ultra small carbon fibers help to address issues but controlling the electrode site geometry is difficult. Here we propose a methodology to create small, pointed fiber electrodes (SPFe). We compare the SPFe to previously made blowtorched fibers in characterization. The SPFe result in small site sizes [Formula: see text] with consistently sharp points (20.8 ± 7.64°). Additionally, these electrodes were able to record and/or stimulate neurons multiple animal models including rat cortex, mouse retina, Aplysia ganglia and octopus axial cord. In rat cortex, these electrodes recorded significantly higher peak amplitudes than the traditional blowtorched fibers. These SPFe may be applicable to a wide range of applications requiring a highly specific interface with individual neurons.
- Published
- 2024
- Full Text
- View/download PDF
5. A Wireless Neural Stimulator IC for Cortical Visual Prosthesis.
- Author
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Lee J, Letner J, Lim J, Sun Y, Jeong S, Kim Y, Koo B, Atzeni G, Liao J, Richie J, Valle ED, Patel P, Jang T, Chestek C, Phillips J, Weiland J, Sylvester D, Kim HS, and Blaauw D
- Abstract
We propose a 0.25 × 0.25 × 0.3 mm (~0.02 mm
3 ) optically powered mote for visual cortex stimulation to restore vision. Up to 1024 implanted motes can be individually addressed. The complete StiMote system was confirmed fully functional when optically powered and cortex stimulation was confirmed in-vivo with a live rat brain.- Published
- 2023
- Full Text
- View/download PDF
6. Full-field, conformal epiretinal electrode array using hydrogel and polymer hybrid technology.
- Author
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Zhou M, Young BK, Valle ED, Koo B, Kim J, and Weiland JD
- Subjects
- Animals, Swine, Electrodes, Implanted, Polymers, Hydrogels, Retina surgery, Elastomers, Microelectrodes, Iridium chemistry, Platinum
- Abstract
Shape-morphable electrode arrays can form 3D surfaces to conform to complex neural anatomy and provide consistent positioning needed for next-generation neural interfaces. Retinal prostheses need a curved interface to match the spherical eye and a coverage of several cm to restore peripheral vision. We fabricated a full-field array that can (1) cover a visual field of 57° based on electrode position and of 113° based on the substrate size; (2) fold to form a compact shape for implantation; (3) self-deploy into a curvature fitting the eye after implantation. The full-field array consists of multiple polymer layers, specifically, a sandwich structure of elastomer/polyimide-based-electrode/elastomer, coated on one side with hydrogel. Electrodeposition of high-surface-area platinum/iridium alloy significantly improved the electrical properties of the electrodes. Hydrogel over-coating reduced electrode performance, but the electrodes retained better properties than those without platinum/iridium. The full-field array was rolled into a compact shape and, once implanted into ex vivo pig eyes, restored to a 3D curved surface. The full-field retinal array provides significant coverage of the retina while allowing surgical implantation through an incision 33% of the final device diameter. The shape-changing material platform can be used with other neural interfaces that require conformability to complex neuroanatomy., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
7. Evaluation of the cytotoxicity and genotoxicity of glufosinate-ammonium at technical and commercial grades in HepG2 cells.
- Author
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Gallardo-Valle ED, Carbajal-Nogueda D, Moreno-Godínez ME, Flores-Alfaro E, Parra-Rojas I, Huerta-Beristain G, Domínguez-Reyes T, and Ramírez-Vargas MA
- Subjects
- Humans, Hep G2 Cells, Comet Assay, Mutagens toxicity, DNA Damage, Pesticides toxicity
- Abstract
Exposure to genotoxic agents is associated with the development of cancer and related diseases. For this reason, assessing the genotoxicity of chemical compounds is necessary. In this line, information about the genotoxic effect of glufosinate-ammonium (GLA) has been reported only for the technical grade. However, humans are frequently exposed to commercial formulations of pesticides. Commercial formulations are characterized by using inner agents that increase toxicity compared to pesticides in technical grade. This study aimed to determine the cytotoxic and genotoxic effects of GLA on HepG2 cells. MTT and comet assays were performed to evaluate cell viability and DNA damage, respectively. HepG2 cells were exposed for 24 h to different concentrations of GLA (at 0.01 µg/mL; 0.04 µg/mL; 0.1 µg/mL; 0.24 µg/mL; 0.52 µg/mL; 1.25 µg/mL; 2.62 µg/mL and 13.12 µg/mL) in commercial- (Finale Ultra®) or technical-grade (GLA
T ). The results indicated that only Finale Ultra® induced a reduction in cell viability at 13.12 µg/mL. Furthermore, exposure to Finale Ultra® or GLAT was associated with increased DNA damage at concentrations from 0.52-13.12- µg/mL. This study shows the genotoxic effect of GLA on HepG2 cells.- Published
- 2023
- Full Text
- View/download PDF
8. Comparing the relative and absolute effect of erenumab: is a 50% response enough? Results from the ESTEEMen study.
- Author
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Ornello R, Baraldi C, Guerzoni S, Lambru G, Andreou AP, Raffaelli B, Gendolla A, Barbanti P, Aurilia C, Egeo G, Cevoli S, Favoni V, Vernieri F, Altamura C, Russo A, Silvestro M, Valle ED, Mancioli A, Ranieri A, Alfieri G, Latysheva N, Filatova E, Talbot J, Cheng S, Holle D, Scheffler A, Nežádal T, Čtrnáctá D, Šípková J, Matoušová Z, Casalena A, Maddestra M, Viola S, Affaitati G, Giamberardino MA, Pistoia F, Reuter U, and Sacco S
- Subjects
- Calcitonin Gene-Related Peptide, Calcitonin Gene-Related Peptide Receptor Antagonists pharmacology, Calcitonin Gene-Related Peptide Receptor Antagonists therapeutic use, Female, Humans, Male, Antibodies, Monoclonal, Humanized therapeutic use, Migraine Disorders drug therapy, Migraine Disorders prevention & control
- Abstract
Background: Monoclonal antibodies acting on the calcitonin gene-related peptide (CGRP) or its receptor have changed migraine preventive treatment. Those treatments have led to reconsidering the outcomes of migraine prevention. Available data mostly considered benefits in terms of relative efficacy (percent or absolute decrease in monthly migraine days [MMDs] or headache days compared with baseline). However, not enough attention has been paid to residual MMDs and/or migraine-related disability in treated patients. In the present study, we aimed at comparing the relative and absolute efficacy of erenumab., Methods: ESTEEMen was a collaborative project among 16 European headache centers which already performed real-life data collections on patients treated with erenumab for at least 12 weeks. For the present study, we performed a subgroup analysis on patients with complete data on MMDs at baseline and at weeks 9-12 of treatment. Starting from efficacy thresholds proposed by previous literature, we classified patients into 0-29%, 30-49%, 50-74%, and ≥75% responders according to MMD decrease from baseline to weeks 9-12 of treatment. For each response category, we reported the median MMDs and Headache Impact test-6 (HIT-6) scores at baseline and at weeks 9-12. We categorized the number of residual MMDs at weeks 9-12 as follows: 0-3, 4-7, 8-14, ≥15. We classified HIT-6 score into four categories: ≤49, 50-55, 56-59, and ≥60. To keep in line with the original scope of the ESTEEMen study, calculations were performed in men and women., Results: Out of 1215 patients, at weeks 9-12, 381 (31.4%) had a 0-29% response, 186 (15.3%) a 30-49% response, 396 (32.6%) a 50-74% response, and 252 (20.7%) a ≥75% response; 246 patients (20.2%) had 0-3 residual MMDs, 443 (36.5%) had 4-7 MMDs, 299 (24.6%) had 8-14 MMDs, and 227 (18.7%) had ≥15 MMDs. Among patients with 50-74% response, 246 (62.1%) had 4-7 and 94 (23.7%) 8-14 residual MMDs, while among patients with ≥75% response 187 (74.2%) had 0-3 and 65 (25.8%) had 4-7 residual MMDs., Conclusions: The present study shows that even patients with good relative response to erenumab may have a clinically non-negligible residual migraine burden. Relative measures of efficacy cannot be enough to thoroughly consider the efficacy of migraine prevention., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
9. Efficacy and safety of erenumab in the real-life setting of S. Antonio Abate Hospital's Headache Center (Gallarate).
- Author
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Valle ED, Di Falco M, Mancioli A, Corbetta S, and La Spina I
- Subjects
- Headache drug therapy, Hospitals, Humans, Antibodies, Monoclonal, Humanized, Temefos
- Published
- 2020
- Full Text
- View/download PDF
10. Clinical Predictors of Progressive Beta-Cell Failure in Type 2 Diabetes.
- Author
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Irace C, Tripolino C, Carallo C, Scavelli FB, Valle ED, Cortese C, and Gnasso A
- Subjects
- Diabetes Mellitus, Type 2 drug therapy, Female, Follow-Up Studies, Humans, Hypoglycemic Agents pharmacology, Hypoglycemic Agents therapeutic use, Insulin-Secreting Cells drug effects, Male, Middle Aged, Proportional Hazards Models, Diabetes Mellitus, Type 2 pathology, Insulin-Secreting Cells pathology
- Abstract
Objectives: The aim of the study was to identify factors associated with progressive beta-cell failure in a cohort of nonselected subjects with type 2 diabetes., Methods: Two hundred twenty-four medical records were evaluated. Progressive beta-cell failure was defined as the following: glycated hemoglobin is higher than 7.5% despite combined drug therapy and appropriate diet (ie, isocaloric or hypocaloric diet depending on body weight) and absence of any illness causing acute hyperglycemia. The following factors were considered as possible predictors: diabetes-related symptoms, fasting plasma glucose at the onset of disease, family history of type 2 diabetes, number of visits per year, and residency. Further potential predictors were disease duration, age, body mass index, estimated glomerular filtration rate, and hypertension and/or hyperlipidemia at the enrollment in the study., Results: The prevalence of beta-cell failure was 41%. Independent predictors of failure were longer disease duration (hazard ratio [HR] for each year of diabetes, 1.03; confidence intervals (CIs), 1.01-1.05; P = 0.03), history of hypertension (HR, 1.90; CIs, 1.73-2.89; P = 0.04), hyperlipidemia (HR, 1.65; CIs, 1.06-2.58; P = 0.03), residence in suburb (HR, 1.78; CIs, 1.06-3.01; P = 0.03), and presence of symptoms at the onset of disease (HR, 2.47; CIs, 1.51-4.03; P = 0.0001)., Conclusions: Patients with long disease duration, hypertension, and hyperlipidemia who are residents in suburbs and had diabetes-related symptoms at diagnosis might deserve intensive treatment to obtain adequate and stable glycemic control.
- Published
- 2015
- Full Text
- View/download PDF
11. Overlapping MRI findings in progressive supranuclear palsy - corticobasal syndrome.
- Author
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Prezzi ED, Vasconcellos LF, and Marussi VH
- Subjects
- Basal Ganglia pathology, Cerebral Cortex pathology, Female, Humans, Middle Aged, Neuroimaging methods, Syndrome, Tomography, Emission-Computed, Single-Photon, Magnetic Resonance Imaging methods, Mesencephalon pathology, Supranuclear Palsy, Progressive pathology
- Published
- 2014
- Full Text
- View/download PDF
12. [Demographic Dynamics and Educational Inequality in Mexico].
- Author
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Giorguli Saucedo SE, Vargas Valle ED, Ulloa VS, Hubert C, and Potter JE
- Abstract
This paper seeks to explore the link between educational processes and Mexico's demographic dynamic. In the tradition of thought on population and development, it has been hypothesized that the population growth rate, family size and migration influence the accumulation of human capital among the school-age population. This study explores the link between the academic performance of youth between the age of 14 and 23 and the youth dependency ratio, teenage fertility and internal and international migration, using data aggregated at the municipal level for the year 2000. The analysis uses indicators on the educational supply at the municipal level based on the administrative statistics of the Public Education Secretariat (SEP).
- Published
- 2010
- Full Text
- View/download PDF
13. Religious Affiliation, Ethnicity, and Child Mortality in Chiapas, México.
- Author
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Valle ED, Potter JE, and Fernández L
- Abstract
We investigate whether there is a relationship between religious affiliation and child mortality among indigenous and nonindigenous groups in Chiapas, México. Our analysis relies on Brass-type estimates of child mortality by ethnicity and religious affiliation and multivariate analyses that adjust for various socioeconomic and demographic factors. The data are from the 2000 Mexican Census 10 percent sample. Among indigenous people, Presbyterians have lower rates of child mortality than Catholics. However, no significant differentials are found in child mortality by religious affiliation among nonindigenous people. The indigenous health ministry of the Presbyterian Church and the social and cultural transformations that tend to accompany religious conversion may have an impact on child survival among disadvantaged populations such as the indigenous people in Chiapas.
- Published
- 2009
- Full Text
- View/download PDF
14. Pulmonary artery rupture by the Swan-Ganz catheter: case report.
- Author
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Schechter MC, Prezzi ED, Cabral G, Fernandes ES, and Vianna AO
- Abstract
Pulmonary artery catheter is frequently used to monitor patients during liver transplantation. Recently developed less invasive methods for estimating cardiac output and pulmonary capillary wedge pressure together with the failure of randomized studies to demonstrate reduced mortality in pulmonary artery catheter-monitored patients, has restricted its applicability. Pulmonary artery rupture by pulmonary artery catheter is a rare, but dangerous complication. The purpose of this report is to describe a pulmonary artery rupture caused by monitorization with a pulmonary artery catheter, reviewing the clinical approach and discussing hemodynamic monitoring with the pulmonary artery catheter during liver transplantation. A 56 year old female patient, with cirrhosis caused by hepatitis C virus (MELD score 26) presented with acute hepatic encephalopathy. She was medicated and received a liver transplantation with invasive monitoring with a pulmonary artery catheter. In the first 24 hours after surgery, the patient presented with hemodynamic instability, low hematocrit, and cardiorespiratory arrest. After cardiopulmonary resuscitation, hemopericardium was diagnosed by transthoracic echocardiography and even after pericardiocentesis the patient developed recurrent hemopericardium. Pulmonary angiography did not disclose large vessellesions. The pulmonary artery rupture diagnosis was only made after sternotomy and direct lesion observation. Complications from use of pulmonary artery catheter are infrequent, however, due to their clinical severity, can cause high morbidity and mortality. A decreased use of pulmonary artery catheter reduced the number of complications observed. New clinical studies comparing pulmonary artery catheter with non-invasive methods for pulmonary capillary wedge pressure measurement must be conducted in liver transplantation.
- Published
- 2009
15. Use of noninvasive positive pressure ventilation and spinal anesthesia during hip replacement arthroplasty in a patient with severe chronic obstructive pulmonary disease: case report.
- Author
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Gonçalves GÂ, Prezzi ED, Carletti GM, Chindamo G, Rocha TH, Varella E, and Vianna AO
- Abstract
Anesthetic management of patients with severe chronic obstructive pulmonary disease is extensively discussed, due to the high rates of complications in this subtype of patients submitted to medium and high complexity surgical procedures. The objective of this study is to report use of noninvasive positive pressure mechanical ventilation - bilevel positive airway pressure - and spinal anesthesia in a patient with severe chronic obstructive pulmonary disease during total hip arthroplasty. An 81 year old, male patient with severe chronic obstructive pulmonary disease (GOLD 4) was submitted to total hip arthroplasty due to a femoral bone fracture under spinal anestesia and noninvasive positive pressure mechanical ventilation-bilevel positive airway pressure with expiratory pressure of 7 cmH2O, inspiratory pressure of 15 cmH2O and O2 flow of 3 L/min. During the procedure, the patient had one episode of bronchospasm that was promptly reverted pharmacologically with no complications in the postoperative period. The combination of less invasive anesthetic and ventilation techniques is easy to apply and may be useful in the perioperative management of patients with high anesthetic morbidity. Interaction between clinical, surgical and anesthetic teams for these cases is very important to reduce the mortality associated with extensive procedures in severe patients.
- Published
- 2008
16. Endobronchial inflammatory pseudotumor: a case report.
- Author
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Sanchez PG, Madke GR, Pilla ES, Foergnes R, Felicetti JC, Valle Ed, and Geyer G
- Subjects
- Adult, Biopsy, Bronchial Diseases pathology, Bronchial Diseases surgery, Bronchoscopy, Cough, Humans, Male, Plasma Cell Granuloma, Pulmonary pathology, Plasma Cell Granuloma, Pulmonary surgery, Tomography, X-Ray Computed, Bronchial Diseases diagnosis, Plasma Cell Granuloma, Pulmonary diagnosis
- Abstract
Inflammatory pseudotumor of the lung is a rare form of benign neoplasia and is generally characterized by a solitary pulmonary nodule. The endobronchial presentation is uncommon. Conservative surgery remains the treatment of choice, and surgeons should always strive to achieve tumor-free margins due to the possibility of local recidivism. This article reports the case of a 36-year-old male patient with recurrent attacks of wheezing and cough. The patient underwent successful bronchoplasty for the resection of an endobronchial inflammatory pseudotumor.
- Published
- 2007
- Full Text
- View/download PDF
17. Characterization of HSP27 phosphorylation induced by microtubule interfering agents: implication of p38 signalling pathway.
- Author
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Casado P, Zuazua-Villar P, Prado MA, Valle ED, Iglesias JM, Martínez-Campa C, Lazo PS, and Ramos S
- Subjects
- Cell Line, Tumor, HSP27 Heat-Shock Proteins, Heat-Shock Proteins chemistry, Humans, JNK Mitogen-Activated Protein Kinases physiology, Microtubules enzymology, Microtubules metabolism, Molecular Chaperones, Neoplasm Proteins chemistry, Paclitaxel pharmacology, Phosphorylation drug effects, Serine metabolism, Vincristine pharmacology, Heat-Shock Proteins metabolism, MAP Kinase Signaling System drug effects, MAP Kinase Signaling System physiology, Microtubules drug effects, Neoplasm Proteins metabolism, Tubulin Modulators pharmacology, p38 Mitogen-Activated Protein Kinases physiology
- Abstract
Vincristine and paclitaxel are widely used antitumoral drugs that interfere with microtubule dynamics. We have previously demonstrated that vincristine induces phosphorylation of HSP27 at serine 82 in MCF-7 cells. In this report, we show that vincristine also causes phosphorylation of serines 78 and 15. Moreover, we demonstrate that phosphorylation of this chaperone is induced by the p38 signalling pathway while the JNK pathway is not implicated. Differences between vincristine and paclitaxel treatments are also appreciated. Thus, while vincristine induces a strong phosphorylation of the three serines, paclitaxel induces a weak phosphorylation of serine 78 and has no effect over serines 82 and 15 phosphorylation. Interestingly, pre-treatment of cells with a ten-fold excess of paclitaxel abolishes vincristine-induced phosphorylation of HSP27.
- Published
- 2007
- Full Text
- View/download PDF
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