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589 results on '"Valladares M"'

1. A randomised phase 2 study comparing different dose approaches of induction treatment of regorafenib in previously treated metastatic colorectal cancer patients (REARRANGE trial)

Author

Tabernero, Josep, Argilés, Guillem, Falcone, Alfredo, Ciardiello, Fortunato, Goldberg, Richard, Bennouna, Jaafar, Argilés, Tabernero, J., Mulet, N., Limón, M.L., Valladares, M., Jiménez, P., Vieitez, J. M<ce:sup loc='post">a</ce:sup>, Grávalos, C., García-Alfonso, P., Santos, C., Páez, D., Tobeña, M., Sastre, J., García Paredes, B., Benavides, M., Aranda, E., Cano, M.T., Loupakis, F., Rguez Garrote, M., Guillén, C., Rivera, Ma F., Safont, J., Hiret, S., Bennouna, J., Pannier, D., Malka, D., Falcone, A., Cremolini, C., Mulet, Nuria, Valladares-Ayerbes, Manuel, Viéitez, José M., Grávalos, Cristina, García-Alfonso, Pilar, Santos, Cristina, Tobeña, María, García-Paredes, Beatriz, Benavides, Manuel, Cano, María T., Loupakis, Fotios, Rodríguez-Garrote, Mercedes, Rivera, Fernando, Goldberg, Richard M., Cremolini, Chiara, Tabernero, Josep M., and Aranda, Enrique

Published
2022
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2. The TRASGO Project. Present Status and Results

Author

García-Castro, D., Ajoor, M., Alvarez-Pol, H., Blanco, A., Cabanelas, P., Callón-Rivas, J., Collazo, J., Clemencio, F., Cuenca-García, J. J., Cruces, M., Fonte, P., Fontenla, Y., Flores, J., Garzón, J. A., Gomis-Moreno, A., Iglesias, A., Kornakov, G., Kurtukian-Nieto, T., Lopes, L., Loureiro, C., Pazos, A., Rodríguez, C., Saraiva, J. P., Seco, M., Valladares, M., Villasante-Marcos, V., and Xuna, J.

Published
2021
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3. Advances in diagnosis of gastrointestinal nematodes in livestock and companion animals

Author

Rinaldi, Laura, primary, Krücken, J., additional, Martinez-Valladares, M., additional, Pepe, P., additional, Maurelli, M.P., additional, de Queiroz, C., additional, Castilla Gómez de Agüero, V., additional, Wang, T., additional, Cringoli, Giuseppe, additional, Charlier, J., additional, Gilleard, J.S., additional, and von Samson-Himmelstjerna, G., additional

Published
2022
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4. Anthelmintic resistance in ruminants: challenges and solutions

Author

Charlier, J., primary, Bartley, D.J., additional, Sotiraki, S., additional, Martinez-Valladares, M., additional, Claerebout, E., additional, von Samson-Himmelstjerna, G., additional, Thamsborg, S.M., additional, Hoste, H., additional, Morgan, E.R., additional, and Rinaldi, L., additional

Published
2022
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5. Influence of BRAF and PIK3CA mutations on the efficacy of FOLFIRI plus bevacizumab or cetuximab as first-line therapy in patients with RAS wild-type metastatic colorectal carcinoma and

Author

Viéitez, J.M., Jiménez, P., Aguilar, E. Aranda, Gómez, A., Gil Calle, S., Salud, A., Valladares, M., Graña, B., García-Alfonso, P., Rivera, F., Quintero, G., Reina, J.J., González Flores, E., Salgado, M., Grande, E., Guillén, C., Garcia Carbonero, R., Flor, M.J., Safont, M.J., La Casta, A., Arévalo, S., Sastre, J., López López, R., Manzano, H., Guillot, M., Hernández Yagüe, X., Arrivi, A., Falcó, E., Gallego, J., Escudero, P., Cabezas, I., Juárez, A., Gálvez, E., Grávalos, C., Robles, L., Polo, E., Dueñas, R., Campos, J.M., Albert, A., Salinas, P., Montagut, C., Provencio, M., Ruiz Casado, A., Muñoz, J., Gil Raga, M., Chilet, M.R., González González, F.J., Massutí, B., López, A., Aparicio, J., Marín, M., Alfaro, J., Zanui, M., Gutiérrez Abad, D., García Tapiador, A.M., García-Girón, C., Molina Saera, J., Torres Sánchez, E., López, I., Bosch, C., Valero, J., Martínez de Prado, P., Cano, M.T., Reina-Zoilo, J.J., Salud-Salvia, A., Robles-Díaz, L., Gil, S., Asensio-Martínez, E., García-Paredes, B., López, R.L., Valladares-Ayerbes, M., Aranda, E., and Díaz-Rubio, E.

Published
2021
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6. Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe

Author

Charlier, J., Rinaldi, L., Musella, V., Ploeger, H.W., Chartier, C., Vineer, H. Rose, Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T.L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E.R., Bartley, D.J., and Claerebout, E.

Published
2020
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11. Author Correction: Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer

Author

Borrero-Palacios, A., Cebrián, A., Gómez del Pulgar, M. T., García-Carbonero, R., Garcia-Alfonso, P., Aranda, E., Elez, E., López-López, R., Cervantes, A., Valladares, M., Nadal, C., Viéitez, J. M., Guillén-Ponce, C., Rodríguez, J., Hernández, I., García, J. L., Vega-Bravo, R., Puime-Otin, A., Martínez-Useros, J., Del Puerto-Nevado, L., Rincón, R., Rodríguez-Remírez, M., Rojo, F., and García-Foncillas, J.

Published
2019
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12. Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer

Author

Borrero-Palacios, A., Cebrián, A., Gómez del Pulgar, M. T., García-Carbonero, R., Garcia-Alfonso, P., Aranda, E., Elez, E., López-López, R., Cervantes, A., Valladares, M., Nadal, C., Viéitez, J. M., Guillén-Ponce, C., Rodríguez, J., Hernández, I., García, J. L., Vega-Bravo, R., Puime-Otin, A., Martínez-Useros, J., Del Puerto-Nevado, L., Rincón, R., Rodríguez-Remírez, M., Rojo, F., and García-Foncillas, J.

Published
2019
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15. 382P Sequential RAS mutation status evaluation in circulating free DNA (cfDNA) in RAS wild type (wt) metastatic colorectal cancer (mCRC) patients (pt) starting first-line (1L) treatment with panitumumab (P) and chemotherapy (CT). PERSEIDA (Idylla Cohort) study

Author

Valladares, M., primary, Safont Aguileria, M.J., additional, González-Flores, E., additional, García Alfonso, P., additional, López Muñoz, A.M., additional, Aranda Aguilar, E., additional, Falco Ferrer, E., additional, Rodriguez-Salas, N., additional, Cirera, L., additional, Llanos-Munoz, M., additional, Aparicio, J., additional, Pimentel, P., additional, Castillo Trujillo, A.O., additional, Salgado Fernandez, M., additional, Salud Salvia, M.A., additional, Vidal Tocino, R., additional, Massuti Sureda, B., additional, Garcia-Carbonero, R., additional, Vicente Conesa, M.A.D.L.A., additional, and Lloansi Vila, A., additional

Published
2022
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19. Varied hydrological regime of a semi-arid coastal wetland

Author

Cuevas Jaime G., Valladares María, Glasner Lucas, Bresciani Etienne, Núñez Paloma, Rojas José L., and González Mercedes

Subjects
instrumental artifacts, sand barrier, diurnal cycles, storm surges, wetlands, Hydraulic engineering, TC1-978
Abstract

Coastal wetlands are transitional ecosystems between land and sea. Participants of citizen science programs have detected frequent floods in wetlands, as well as small pools that appear and then disappear. Considering that it is not clear whether their main hydrologic drivers are of marine or continental origin, we studied the El Culebrón wetland located in the Chilean semi-arid zone. El Culebrón is strongly influenced by extreme rain events. This wetland also experiences seasonal changes in its water stage (WS). A high mean sea level agreed with 41% of the WS rises. High intensity storm surges coincided with 53% of WS peaks. A small tsunami in 2022 impacted the WS, and another very intense tsunami flooded it in 2015. An apparent diurnal cycle in the WS was discarded due to an instrumental artifact. The combination of the aforementioned factors provided an explanation for 91% of the WS rises. The probable and novel mechanism for sea level and storm surge influence on WS is the formation of a sand barrier between the coastal lagoon and the sea. As a whole, El Culebrón receives varied influences from both the sea and the mainland, but it seems to be more dependent on freshwater sources.

Published
2024
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22. Anthelmintic resistance in ruminants:challenges and solutions

Author

Rollinson, David, Stothard, Russell, Charlier, J., Bartley, D. J., Sotiraki, S., Martinez-Valladares, M., Claerebout, E., von Samson-Himmelstjerna, G., Thamsborg, S. M., Hoste, H., Morgan, E. R., Rinaldi, L., Rollinson, David, Stothard, Russell, Charlier, J., Bartley, D. J., Sotiraki, S., Martinez-Valladares, M., Claerebout, E., von Samson-Himmelstjerna, G., Thamsborg, S. M., Hoste, H., Morgan, E. R., and Rinaldi, L.

Abstract

Anthelmintic resistance (AR) is a growing concern for effective parasite control in farmed ruminants globally. Combatting AR will require intensified and integrated research efforts in the development of innovative diagnostic tests to detect helminth infections and AR, sustainable anthelmintic treatment strategies and the development of complementary control approaches such as vaccination and plant-based control. It will also require a better understanding of socio-economic drivers of anthelmintic treatment decisions, in order to support a behavioural shift and develop targeted communication strategies that promote the uptake of evidence-based sustainable solutions. Here, we review the state-of-the-art in these different fields of research activity related to AR in helminths of livestock ruminants in Europe and beyond. We conclude that in the advent of new challenges and solutions emerging from continuing spread of AR and intensified research efforts, respectively, there is a strong need for transnational multi-actor initiatives. These should involve all key stakeholders to develop indicators of infection and sustainable control, set targets and promote good practices to achieve them.

Published
2022

29. Corrigendum to “Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe” [Prev. Vet. Med. 182 (2020) 105103]

Author

Charlier, J., Rinaldi, L., Musella, V., Ploeger, H.W., Chartier, C., Rose Vineer, H., Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T.L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E.R., Bartley, D.J., and Claerebout, E.

Published
2021
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31. Randomized study of weekly irinotecan plus high-dose 5-fluorouracil (FUIRI) versus biweekly irinotecan plus 5-fluorouracil/leucovorin (FOLFIRI) as first-line chemotherapy for patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors Study

Author

Aranda, E., Valladares, M., Martinez-Villacampa, M., Benavides, M., Gomez, A., Massutti, B., Marcuello, E., Constenla, M., Cámara, J.C., Carrato, A., Dueñas, R., Reboredo, M., Navarro, M., and Díaz-Rubio, E.

Published
2009
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33. Palliative Sedation in COVID-19 End-of-Life Care. Retrospective Cohort Study

Author

Ramos-Rincon J, Moreno-Perez O, Gomez-Martinez N, Priego-Valladares M, Climent-Grana E, Marti-Pastor A, Portilla-Sogorb J, Sanchez-Martinez R, and Merino E

Subjects
symptom assessment, palliative care, death, COVID-19, palliative medicine
Abstract

Background and Objectives: Descriptions of end-of-life in COVID-19 are limited to small cross-sectional studies. We aimed to assess end-of-life care in inpatients with COVID-19 at Alicante General University Hospital (ALC) and compare differences according to palliative and non-palliative sedation. Material and Methods: This was a retrospective cohort study in inpatients included in the ALC COVID-19 Registry (PCR-RT or antigen-confirmed cases) who died during conventional admission from 1 March to 15 December 2020. We evaluated differences among deceased cases according to administration of palliative sedation. Results: Of 747 patients evaluated, 101 died (13.5%). Sixty-eight (67.3%) died in acute medical wards, and 30 (44.1%) received palliative sedation. The median age of patients with palliative sedation was 85 years; 44% were women, and 30% of cases were nosocomial. Patients with nosocomial acquisition received more palliative sedation than those infected in the community (81.8% [9/11] vs 36.8% [21/57], p = 0.006), and patients admitted with an altered mental state received it less (20% [6/23] vs. 53.3% [24/45], p = 0.032). The median time from admission to starting palliative sedation was 8.5 days (interquartile range [IQR] 3.0-14.5). The main symptoms leading to palliative sedation were dyspnea at rest (90%), pain (60%), and delirium/agitation (36.7%). The median time from palliative sedation to death was 21.8 h (IQR 10.4-41.1). Morphine was used in all palliative sedation perfusions: the main regimen was morphine + hyoscine butyl bromide + midazolam (43.3%). Conclusions: End-of-life palliative sedation in patients with COVID-19 was initiated quite late. Clinicians should anticipate the need for palliative sedation in these patients and recognize the breathlessness, pain, and agitation/delirium that foreshadow death.

Published
2021

34. Mortality and Prognostic Factors in Patients over 90 Years of Age Admitted in Internal Medicine: A Spanish Prospective Cohort Study

Author

Ramos-Rincon J, Albert-Ribera M, Priego-Valladares M, Gonzalez-de-la-Aleja P, Garcia-Navarro M, and Sanchez-Martinez R

Subjects
nonagenarians, dependence, comprehensive geriatric assessment, mortality
Abstract

Background: The prevalence of multimorbidity and the number of chronic pathologies increases with age, and hospitalization rates are higher in very elderly patients. Aims: To identify predictors of mortality in patients aged 90 years or more at 6 and 12 months after admission to the internal medicine ward. Materials and methods: Prospective cohort study in patients aged 90 years or older who were admitted to the internal medicine ward of Alicante General University Hospital from November 2018 to March 2019. We collected data for patient scores on the Barthel, Lawton-Brody, and Short Portable Mental Status Questionnaire; a nutritional questionnaire; the Charlson index; PALIAR and PROFUND prognostic indexes; and mortality at 6 and 12 months. Results: In the bivariate analysis adjusted for gender and comorbidity, malnutrition was associated with mortality at 6 and 12 months (odds ratio (OR) 5.17, 95% confidence interval (C11 1.30, 20.50; OR 7.78, 95% CI 1.47, 40.9, respectively), as were moderate-severe cognitive impairment (6 months: OR 12.0, 95% CI 2.79, 52.0; 12 months: OR 10.73, 95% CI 2.40, 47.8) and high-risk scores on the PALIAR (6 months: OR 9.18, 95% CI 1.99, 42.27;12 months: OR 11.7, 95% CI 2.62, 51.60) and PROFUND (6 months: OR 10.7, 95% CI 1.68, 68.80; 12 months: OR 20.9, 95% CI 3.15, 139.0) prognostic indexes. The Barthel index was associated with mortality only at 6 months (OR 6.16; 95% CI 1.69, 22.4). Conclusions: In nonagenarian inpatients, a worse score on the comprehensive assessment and a higher score on prognostic indexes were associated with increased risk of mortality at 6 and 12 months. Copyright (C) 2021, Taiwan Society of Geriatric Emergency & Critical Care Medicine.

Published
2021

36. Corrigendum to “Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe” [Prev. Vet. Med. 182 (2020) 105103]

Author

Klinische infectiologie en microb. lab., dI&I I&I-4, Charlier, J., Rinaldi, L., Musella, V., Ploeger, H.W., Chartier, C., Rose Vineer, H., Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T.L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E.R., Bartley, D.J., Claerebout, E., Klinische infectiologie en microb. lab., dI&I I&I-4, Charlier, J., Rinaldi, L., Musella, V., Ploeger, H.W., Chartier, C., Rose Vineer, H., Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T.L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E.R., Bartley, D.J., and Claerebout, E.

Published
2021

41. Influence of BRAF and PIK3CA mutations on the efficacy of FOLFIRI plus bevacizumab or cetuximab as first-line therapy in patients with RAS wild-type metastatic colorectal carcinoma and <3 baseline circulating tumour cells: the randomised phase II VISNÚ-2 study

Author

Sastre, J., primary, García-Alfonso, P., additional, Viéitez, J.M., additional, Cano, M.T., additional, Rivera, F., additional, Reina-Zoilo, J.J., additional, Salud-Salvia, A., additional, Quintero, G., additional, Robles-Díaz, L., additional, Safont, M.J., additional, La Casta, A., additional, Gil, S., additional, Polo, E., additional, Asensio-Martínez, E., additional, García-Paredes, B., additional, López, R.L., additional, Guillot, M., additional, Valladares-Ayerbes, M., additional, Aranda, E., additional, Díaz-Rubio, E., additional, Jiménez, P., additional, Aguilar, E. Aranda, additional, Gómez, A., additional, Gil Calle, S., additional, Salud, A., additional, Valladares, M., additional, Graña, B., additional, Reina, J.J., additional, González Flores, E., additional, Salgado, M., additional, Grande, E., additional, Guillén, C., additional, Garcia Carbonero, R., additional, Flor, M.J., additional, Arévalo, S., additional, Sastre, J., additional, López López, R., additional, Manzano, H., additional, Hernández Yagüe, X., additional, Arrivi, A., additional, Falcó, E., additional, Gallego, J., additional, Escudero, P., additional, Cabezas, I., additional, Juárez, A., additional, Gálvez, E., additional, Grávalos, C., additional, Robles, L., additional, Dueñas, R., additional, Campos, J.M., additional, Albert, A., additional, Salinas, P., additional, Montagut, C., additional, Provencio, M., additional, Ruiz Casado, A., additional, Muñoz, J., additional, Gil Raga, M., additional, Chilet, M.R., additional, González González, F.J., additional, Massutí, B., additional, López, A., additional, Aparicio, J., additional, Marín, M., additional, Alfaro, J., additional, Zanui, M., additional, Gutiérrez Abad, D., additional, García Tapiador, A.M., additional, García-Girón, C., additional, Molina Saera, J., additional, Torres Sánchez, E., additional, López, I., additional, Bosch, C., additional, Valero, J., additional, and Martínez de Prado, P., additional

Published
2021
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44. Electrochemical Evaluation of Chrysin Flavonoid as Corrosion Inhibitor for Mild Steel in Sulphuric Acid Solution

Author

Díaz, M. Y., Valladares, M. G., Menchaca, E. C., Uruchurtu, J., Díaz, M. Y., Valladares, M. G., Menchaca, E. C., and Uruchurtu, J.

Abstract

Recently research is focused on natural organic compounds as metallic corrosion inhibitors demonstrating good corrosion protection and efficiencies. Steel corrosion behavior in acid media was evaluated in the presence of a pure natural flavonoid metabolite named Chrysin present in different plants. The evaluation of corrosion protection was studied using polarization curves, electrochemical impedance spectroscopy (EIS) and electrochemical current density under potentiostatic conditions. Polarization curves present active dissolution and at high overpotentials two passivation regions were found. Slight corrosion protection was obtained from EIS measurements and potentiostatic curves at three different anodic potentials: -370, +216 and +600 mV, revealed a more stable passive film in the presence of Chrysin at both passive regions. High corrosion protection was obtained on the film formed at +600 mV during the first 4 hours of immersion.

Published
2020

45. Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe

Author

Klinische infectiologie en microb. lab., dI&I I&I-4, Charlier, J., Rinaldi, L., Musella, V., Ploeger, H. W., Chartier, C., Vineer, H. Rose, Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T. L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E. R., Bartley, D. J., Claerebout, E., Klinische infectiologie en microb. lab., dI&I I&I-4, Charlier, J., Rinaldi, L., Musella, V., Ploeger, H. W., Chartier, C., Vineer, H. Rose, Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T. L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E. R., Bartley, D. J., and Claerebout, E.

Published
2020

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