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6. Applications of Metallic Nanoparticles in Lung Cancer Treatment

Author

Kumar, Harsh, Akash, K., Bhardwaj, Kanchan, Taneja, Akriti, Singh, Shubhangi, Manickam, Sivakumar, Valko, Marian, Kuča, Kamil, Rezaei, Nima, Series Editor, Aguiar, Rodrigo, Editorial Board Member, Ahmed, Atif A., Editorial Board Member, Ambrosio, Maria R., Editorial Board Member, Artac, Mehmet, Editorial Board Member, Augustine, Tanya N., Editorial Board Member, Bambauer, Rolf, Editorial Board Member, Bhat, Ajaz Ahmad, Editorial Board Member, Bertolaccini, Luca, Editorial Board Member, Bianchini, Chiara, Editorial Board Member, Cavic, Milena, Editorial Board Member, Chakrabarti, Sakti, Editorial Board Member, Cho, William C. S., Editorial Board Member, Czarnecka, Anna M., Editorial Board Member, Domingues, Cátia, Editorial Board Member, Eşkazan, A. Emre, Editorial Board Member, Fares, Jawad, Editorial Board Member, Fonseca Alves, Carlos E., Editorial Board Member, Fru, Pascaline, Editorial Board Member, Da Gama Duarte, Jessica, Editorial Board Member, García, Mónica C., Editorial Board Member, Gener, Melissa A.H., Editorial Board Member, Estrada Guadarrama, José Antonio, Editorial Board Member, Hargadon, Kristian M., Editorial Board Member, Holvoet, Paul, Editorial Board Member, Jurisic, Vladimir, Editorial Board Member, Kabir, Yearul, Editorial Board Member, Katsila, Theodora, Editorial Board Member, Kleeff, Jorg, Editorial Board Member, Liang, Chao, Editorial Board Member, Tan, Mei Lan, Editorial Board Member, Li, Weijie, Editorial Board Member, Prado López, Sonia, Editorial Board Member, Macha, Muzafar A., Editorial Board Member, Malara, Natalia, Editorial Board Member, Orhan, Adile, Editorial Board Member, Prado-Garcia, Heriberto, Editorial Board Member, Pérez-Velázquez, Judith, Editorial Board Member, Rashed, Wafaa M., Editorial Board Member, Sanguedolce, Francesca, Editorial Board Member, Sorrentino, Rosalinda, Editorial Board Member, Shubina, Irina Zh., Editorial Board Member, de Araujo, Heloisa Sobreiro Selistre, Editorial Board Member, Torres-Suárez, Ana Isabel, Editorial Board Member, Włodarczyk, Jakub, Editorial Board Member, Yeong, Joe Poh Sheng, Editorial Board Member, Toscano, Marta A., Editorial Board Member, Wong, Tak-Wah, Editorial Board Member, Yin, Jun, Editorial Board Member, and Yu, Bin, Editorial Board Member

Published
2024
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12. Frentizole derivatives with mTOR inhibiting and senomorphic properties

Author

Chrienova, Zofia, Rysanek, David, Novak, Josef, Vasicova, Pavla, Oleksak, Patrik, Andrys, Rudolf, Skarka, Adam, Dumanovic, Jelena, Milovanovic, Zoran, Jacevic, Vesna, Chvojkova, Marketa, Holubova, Kristina, Vales, Karel, Skoupilova, Veronika, Valko, Marian, Jomova, Klaudia, Alomar, Suliman Y., Botelho, Fernanda D., Franca, Tanos C.C., Kuca, Kamil, Hodny, Zdenek, and Nepovimova, Eugenie

Published
2023
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22. Age-associated changes in innate and adaptive immunity: role of the gut microbiota.

Author

Haoyu Gao, Nepovimova, Eugenie, Adam, Vojtech, Heger, Zbynek, Valko, Marian, Qinghua Wu, and Kuca, Kamil

Subjects
OLDER people, GUT microbiome, NATURAL immunity, HUMAN microbiota, B cells
Abstract

Aging is generally regarded as an irreversible process, and its intricate relationship with the immune system has garnered significant attention due to its profound implications for the health and well-being of the aging population. As people age, a multitude of alterations occur within the immune system, affecting both innate and adaptive immunity. In the realm of innate immunity, aging brings about changes in the number and function of various immune cells, including neutrophils, monocytes, and macrophages. Additionally, certain immune pathways, like the cGAS-STING, become activated. These alterations can potentially result in telomere damage, the disruption of cytokine signaling, and impaired recognition of pathogens. The adaptive immune system, too, undergoes a myriad of changes as age advances. These include shifts in the number, frequency, subtype, and function of T cells and B cells. Furthermore, the human gut microbiota undergoes dynamic changes as a part of the aging process. Notably, the interplay between immune changes and gut microbiota highlights the gut's role in modulating immune responses and maintaining immune homeostasis. The gut microbiota of centenarians exhibits characteristics akin to those found in young individuals, setting it apart from the microbiota observed in typical elderly individuals. This review delves into the current understanding of how aging impacts the immune system and suggests potential strategies for reversing aging through interventions in immune factors. [ABSTRACT FROM AUTHOR]

Published
2024
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23. c-Jun N-terminal kinase signaling in aging.

Author

Yihao Li, Li You, Nepovimova, Eugenie, Adam, Vojtech, Heger, Zbynek, Jomova, Klaudia, Valko, Marian, Qinghua Wu, and Kuca, Kamil

Subjects
PSYCHOLOGICAL aspects of aging, PROTEINS, CELL communication, GUT microbiome, BRAIN, APOPTOSIS, CELLULAR signal transduction, GASTROINTESTINAL system, FIBROSIS, CIRCADIAN rhythms, TRANSFERASES, HEALTH promotion, STEM cells, EXTRACELLULAR matrix, T-cell exhaustion, LONGEVITY
Abstract

Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the precise underlying mechanisms, particularly the involvement of specific molecular regulatory proteins in the aging process, remain insufficiently understood. Emerging evidence indicates that c-Jun N-terminal kinase (JNK) serves as a potential regulator within the intricate molecular clock governing aging-related processes. JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate β-galactosidase activity, and induce telomere shortening, thereby contributing to immune system aging. Moreover, the circadian rhythm protein is implicated in JNK-mediated aging. Through this comprehensive review, we meticulously elucidate the intricate regulatory mechanisms orchestrated by JNK signaling in aging processes, offering unprecedented molecular insights with significant implications and highlighting potential therapeutic targets. We also explore the translational impact of targeting JNK signaling for interventions aimed at extending healthspan and promoting longevity. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Antimicrobial and antifungal activities of bifunctional cooper(ii) complexes with non-steroidal anti-inflammatory drugs, flufenamic, mefenamic and tolfenamic acids and 1,10-phenanthroline

Author

Hudecova Lenka, Jomova Klaudia, Lauro Peter, Simunkova Miriama, Alwasel Saleh H., Alhazza Ibrahim M., Moncol Jan, and Valko Marian

Subjects
cu(ii) complexes, antimicrobial activity, antifungal activity, nsaid, escherichia coli, saccharomyces cerevisiae, Chemistry, QD1-999
Abstract

Cooper(ii) complexes represent a promising group of compounds with antimicrobial and antifungal properties. In the present work, a series of Cu(ii) complexes containing the non-steroidal anti-inflammatory drugs, tolfenamic acid, mefenamic acid and flufenamic acid as their redox-cycling functionalities, and 1,10-phenanthroline as an intercalating component, has been studied. The antibacterial activities of all three complexes, [Cu(tolf-O,O′)2(phen)] (1), [Cu(mef-O,O′)2(phen)] (2) and [Cu(fluf-O,O′)2(phen)] (3), were tested against the prokaryotic model organisms Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) and their antifungal activities were evaluated towards the yeast, Saccharomyces cerevisiae (S. cerevisiae). The antibacterial activity of both strains has been compared with the antibiotic Neomycin. The calculated IC50 values revealed slight differences in the antibacterial activities of the complexes in the order 1 ∼ 3 > 2. The most profound growth inhibition of E. coli was observed, at its highest concentration, for the complex 1, which contains chlorine atoms in the ligand environment. The trend obtained from IC50 values is generally in agreement with the determined MIC values. Similarly, the complex 1 showed the greatest growth inhibition of the yeast S. cerevisiae and the overall antifungal activities of the Cu(ii) complexes were found to follow the order 1 > 3 ≫ 2. However, for complex 2, even at the highest concentration tested (150 μM), a 50% decrease in yeast growth was not achieved. It appears that the most potent antimicrobial and antifungal Cu(ii) complexes are those containing halogenated NSAIDs. The mechanisms by which Cu(ii) complexes cause antibacterial and antifungal activities can be understood on the basis of redox-cycling reactions between cupric and cuprous species which lead to the formation of free radicals. The higher efficacy of the Cu(ii) complexes against bacterial cells may be due to an absence of membrane-protected nuclear DNA, meaning that on entering a cell, they can interact directly with its DNA. Contrastingly, for the complexes to interact with the DNA in yeast cells, they must first penetrate through the nuclear membrane.

Published
2020
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33. Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality: Structure, SOD-mimetic activity, interaction with albumin, DNA damage study and anticancer activity

Author

Simunkova, Miriama, Lauro, Peter, Jomova, Klaudia, Hudecova, Lenka, Danko, Martin, Alwasel, Saleh, Alhazza, Ibrahim M., Rajcaniova, Simona, Kozovska, Zuzana, Kucerova, Lucia, Moncol, Jan, Svorc, Lubomir, and Valko, Marian

Published
2019
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38. Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).

Author

Huang, Xueqin, You, Li, Nepovimova, Eugenie, Psotka, Miroslav, Malinak, David, Valko, Marian, Sivak, Ladislav, Korabecny, Jan, Heger, Zbynek, Adam, Vojtech, Wu, Qinghua, and Kuca, Kamil

Subjects
PHOSPHATIDYLINOSITOL 3-kinases, PROTEIN kinases, DNA repair, DRUG resistance in cancer cells, KINASES, COMBINATION drug therapy, PHOSPHOINOSITIDES
Abstract

Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberrant stimulation of the PI3K/AKT/mTOR signalling pathway are linked to a plethora of diseases including cancer. In recent decades, numerous inhibitors related to the PI3K/AKT/mTOR signalling have made great strides in cancer treatment, like copanlisib and sirolimus. Notably, most of the PIKK inhibitors (such as VX-970 and M3814) related to DNA damage response have also shown good efficacy in clinical trials. However, these drugs still require a suitable combination therapy to overcome drug resistance or improve antitumor activity. Based on the aforementioned facts, we summarised the efficacy of PIKK, PI3K, and AKT inhibitors in the therapy of human malignancies and the resistance mechanisms of targeted therapy, in order to provide deeper insights into cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Formulation of pH-responsive highly swellable hydrogel scaffolds for controlled release of tramadol HCl: characterization and biocompatibility evaluation

Author

Abdullah, Zainab, primary, Ashraf, Muhammad Umer, additional, Barkat, Kashif, additional, Badshah, Syed Faisal, additional, Rehman, Umaira, additional, Razzaq, Asma, additional, Mahmood, Asif, additional, Ulhaq, Farid, additional, Chopra, Hitesh, additional, Rashid, Summya, additional, Valko, Marian, additional, Alomar, Suliman, additional, Kuca, Kamil, additional, and Sharma, Rohit, additional

Published
2023
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49. Mercury Toxicity

Author

Jomova, Klaudia, Valko, Marian, Kretsinger, Robert H., editor, Uversky, Vladimir N., editor, and Permyakov, Eugene A., editor

Published
2013
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