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3. The development of 2 clonally and histologically distinct subtypes of extranodal B-cell lymphomas in the brain and skin in 1 individual

Author

Joffe, Daniel, primary, Rohan, Thomas Z., additional, Mandel, Jenna, additional, Suriano, Jayson, additional, Banner, Lauren, additional, Valiga, Alexander, additional, Porcu, Pierluigi, additional, Gong, Jerald Z., additional, Lee, Jason B., additional, Alpdogan, Onder, additional, and Nikbakht, Neda, additional

Published
2024
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4. The Development of 2 Clonally and Histologically Distinct Subtypes of Extranodal B-Cell Lymphomas in the Brain and Skin in 1 Individual

Author

Joffe, Daniel, Rohan, Thomas Z., Mandel, Jenna, Suriano, Jayson, Banner, Lauren, Valiga, Alexander, Porcu, Pierluigi, Gong, Jerald Z., Lee, Jason B., Alpdogan, Onder, Nikbakht, Neda, Joffe, Daniel, Rohan, Thomas Z., Mandel, Jenna, Suriano, Jayson, Banner, Lauren, Valiga, Alexander, Porcu, Pierluigi, Gong, Jerald Z., Lee, Jason B., Alpdogan, Onder, and Nikbakht, Neda

Published
2024

5. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Author

Kaur, Amanpreet, Webster, Marie R, Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H, Dang, Vanessa M, Appleton, Jessica, O’Connell, Michael P, Cheng, Phil, Valiga, Alexander A, Morissette, Rachel, McDonnell, Nazli B, Ferrucci, Luigi, Kossenkov, Andrew V, Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H, Lehrmann, Elin, Becker, Kevin G, Flaherty, Keith T, Frederick, Dennie T, Wargo, Jennifer A, Cooper, Zachary A, Tetzlaff, Michael T, Hudgens, Courtney, Aird, Katherine M, Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S, Chan, Matthew, Menzies, Alexander M, Long, Georgina V, Johnson, Douglas B, Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W, Bosenberg, Marcus, Ribas, Antoni, and Weeraratna, Ashani T

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Adult, Aging, Animals, Cell Line, Tumor, Culture Media, Conditioned, DNA Damage, DNA-(Apurinic or Apyrimidinic Site) Lyase, Disease Progression, Drug Resistance, Neoplasm, Fibroblasts, Humans, Indoles, Male, Melanoma, Membrane Proteins, Mice, Microphthalmia-Associated Transcription Factor, Middle Aged, Molecular Targeted Therapy, Neoplasm Metastasis, Neovascularization, Pathologic, Oxidative Stress, Phenotype, Reactive Oxygen Species, Sulfonamides, Tumor Microenvironment, Vemurafenib, Wnt Signaling Pathway, Wnt1 Protein, beta Catenin, General Science & Technology
Abstract

Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment on tumour progression have been largely unexplored. Since dermal fibroblasts can have profound impacts on melanoma progression, we examined whether age-related changes in dermal fibroblasts could drive melanoma metastasis and response to targeted therapy. Here we find that aged fibroblasts secrete a Wnt antagonist, sFRP2, which activates a multi-step signalling cascade in melanoma cells that results in a decrease in β-catenin and microphthalmia-associated transcription factor (MITF), and ultimately the loss of a key redox effector, APE1. Loss of APE1 attenuates the response of melanoma cells to DNA damage induced by reactive oxygen species, rendering the cells more resistant to targeted therapy (vemurafenib). Age-related increases in sFRP2 also augment both angiogenesis and metastasis of melanoma cells. These data provide an integrated view of how fibroblasts in the aged microenvironment contribute to tumour progression, offering new possibilities for the design of therapy for the elderly.

Published
2016

9. Supplementary Figure S6 from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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10. Data from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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11. Supplementary Data Figure Legends from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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12. Supplementary Table 2 from Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, primary, Webster, Marie R., primary, Valiga, Alexander A., primary, Kaur, Amanpreet, primary, Vultur, Adina, primary, Li, Ling, primary, Herlyn, Meenhard, primary, Villanueva, Jessie, primary, Liu, Qin, primary, Yin, Xiangfan, primary, Widura, Sandy, primary, Nelson, Janelle, primary, Ruiz, Nivia, primary, Camilli, Tura C., primary, Indig, Fred E., primary, Flaherty, Keith T., primary, Wargo, Jennifer A., primary, Frederick, Dennie T., primary, Cooper, Zachary A., primary, Nair, Suresh, primary, Amaravadi, Ravi K., primary, Schuchter, Lynn M., primary, Karakousis, Giorgos C., primary, Xu, Wei, primary, Xu, Xiaowei, primary, and Weeraratna, Ashani T., primary

Published
2023
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13. Distinguishing Dystrophic Calcification from Calciphylaxis

Author

Jones, Elizabeth, Valiga, Alexander, Solowey, Miriam, Jones, Elizabeth, Valiga, Alexander, and Solowey, Miriam

Abstract

Introduction Calcinosis cutis, a disorder in which calcium salts deposit in skin and subcutis, is categorized into five subtypes: dystrophic calcification, metastatic calcification, idiopathic calcification, iatrogenic calcification, and calciphylaxis. Dystrophic calcification, the most common subtype, typically results from local tissue damage1,2 and is proposed to be caused by the release of phosphate binding proteins by necrotic cells in response to tissue damage, inflammation, or hypoxia.2 The condition often presents with nontender nodules of the skin or subcutis and normal serum calcium. Calciphylaxis is believed to be caused by impaired inhibition of calcification in the microvasculature.3 A deficiency in carboxylated matrix Gla protein, a vitamin K dependent inhibitor of vascular calcification, has been associated with calciphylaxis.3 Conditions resulting in vitamin K deficiency, including Warfarin usage and end stage renal disease, have been implicated.3 Several causes of nonuremic calciphylaxis have been reported, notably in association with alcoholic cirrhosis.1,4,5 Additional risk factors include hypercalcemia, hyperphosphatemia, and hyperparathyroidism.3 Intramural vascular calcification of small to medium-sized vessels, typically of the dermis and subcutaneous fat, is a key pathologic diagnostic criterion of calciphylaxis.1 Following medial calcification, subintimal fibroplasia and thrombosis result in vascular occlusion, ischemia, inflammation, and necrosis of surrounding tissue.3 Consequently, calciphylaxis is associated with severely painful lesions.3 Diagnosis requires clinicopathologic correlation as diagnostic histopathological findings of intramural calcification of small vessels and vasculopathy can be subtle. The following case underscores how variations in the clinicopathologic presentation of dystrophic calcification and calciphylaxis can create diagnostic challenges.

Published
2023

16. Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

Author

Webster, Marie R., Xu, Mai, Kinzler, Kathryn A., Kaur, Amanpreet, Appleton, Jessica, OʼConnell, Michael P., Marchbank, Katie, Valiga, Alexander, Dang, Vanessa M., Perego, Michela, Zhang, Gao, Slipicevic, Ana, Keeney, Frederick, Lehrmann, Elin, Wood, William, III, Becker, Kevin G., Kossenkov, Andrew V., Frederick, Dennie T., Flaherty, Keith T., Xu, Xiaowei, Herlyn, Meenhard, Murphy, Maureen E., and Weeraratna, Ashani T.

Published
2015
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21. Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

Author

Webster, Marie R., primary, Fane, Mitchell E., additional, Alicea, Gretchen M., additional, Basu, Subhasree, additional, Kossenkov, Andrew V., additional, Marino, Gloria E., additional, Douglass, Stephen M., additional, Kaur, Amanpreet, additional, Ecker, Brett L., additional, Gnanapradeepan, Keerthana, additional, Ndoye, Abibatou, additional, Kugel, Curtis, additional, Valiga, Alexander, additional, Palmer, Jessica, additional, Liu, Qin, additional, Xu, Xiaowei, additional, Morris, Jessicamarie, additional, Yin, Xiangfan, additional, Wu, Hong, additional, Xu, Wei, additional, Zheng, Cathy, additional, Karakousis, Giorgos C., additional, Amaravadi, Ravi K., additional, Mitchell, Tara C., additional, Almeida, Filipe V., additional, Xiao, Min, additional, Rebecca, Vito W., additional, Wang, Ying-Jie, additional, Schuchter, Lynn M., additional, Herlyn, Meenhard, additional, Murphy, Maureen E., additional, and Weeraratna, Ashani T., additional

Published
2020
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22. Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Author

Kaur, Amanpreet, Webster, Marie R., Marchbank, Katie, Behera, Reeti, Ndoye, Abibatou, Kugel, Curtis H., Dang, Vanessa M., Appleton, Jessica, OConnell, Michael P., Cheng, Phil, Valiga, Alexander A., Morissette, Rachel, McDonnell, Nazli B., Ferrucci, Luigi, Kossenkov, Andrew V., Meeth, Katrina, Tang, Hsin-Yao, Yin, Xiangfan, Wood, William H., Lehrmann, Elin, Becker, Kevin G., Flaherty, Keith T., Frederick, Dennie T., Wargo, Jennifer A., Cooper, Zachary A., Tetzlaff, Michael T., Hudgens, Courtney, Aird, Katherine M., Zhang, Rugang, Xu, Xiaowei, Liu, Qin, Bartlett, Edmund, Karakousis, Giorgos, Eroglu, Zeynep, Lo, Roger S., Chan, Matthew, Menzies, Alexander M., Long, Georgina V., Johnson, Douglas B., Sosman, Jeffrey, Schilling, Bastian, Schadendorf, Dirk, Speicher, David W., Bosenberg, Marcus, Ribas, Antoni, and Weeraratna, Ashani T.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Amanpreet Kaur; Marie R. Webster; Katie Marchbank; Reeti Behera; Abibatou Ndoye; Curtis H. Kugel; Vanessa M. Dang; Jessica Appleton; Michael P. OConnell; Phil Cheng; Alexander A. Valiga; Rachel Morissette; [...]

Published
2016
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23. Sarcomatoid Dedifferentiated Melanoma: The Diagnostic Role of Next-Generation Sequencing

Author

Valiga, Alexander A., Fuller, Collin G., Doyle, Jessica A., and Lee, Jason B.

Abstract

Sarcomatoid dedifferentiated melanoma (SDDM) represents a diagnostic challenge as this cutaneous spindle cell melanoma lacks expression of classic melanocytic markers including S100, SOX10, Melan-A, HMB45, and MITF. The expression of the emerging melanoma marker preferentially expressed antigen in melanoma (PRAME) in SDDM is largely unknown. In this article, a case of SDDM arising in association with a nodular melanoma is highlighted. A 65-year-old man presented with a several week history of an ulcerated lesion on the right medial knee. A shave biopsy of the lesion revealed a biphasic neoplasm, which consisted of a centrally located poorly differentiated spindle cell component and an adjacent nodular component consisting of atypical melanocytes arranged in nests and fascicles. While the nodular component stained for S100, SOX10, and Melan-A, the spindle cell component failed to stain for these conventional melanocytic markers, only staining diffusely for CD10 and faintly for CD68. Both components stained for PRAME diffusely albeit less intensely within the spindle cell component. Next-generation DNA sequencing assay of the microdissected biphasic components revealed a shared mutation of NRAS. The results of the PRAME immunohistochemical stain and next-generation DNA sequencing assay facilitated in establishing the diagnosis of SDDM in association with nodular melanoma.

Published
2022
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25. Abstract 993: Wnt-er is coming: WNT5A promotes a slow cycling phenotype via p53 in conditions of stress

Author

Webster, Marie R., primary, Fane, Mitchell, additional, Kaur, Amanpreet, additional, Alicea, Gretchen, additional, Ecker, Brett L., additional, Ndoye, Abibatou, additional, Kugel, Curtis, additional, Basu, Subhasree, additional, Valiga, Alexander, additional, Appleton, Jessica L., additional, Murphy, Maureen E., additional, and Weeraratna, Ashani, additional

Published
2018
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26. Rise in male cosmetic procedures in dermatology: A 4.5‐year clinical evaluation.

Author

Wang, Jordan V., Valiga, Alexander, Albornoz, Christian A., and Geronemus, Roy G.

Subjects
*PHYSICIANS, *GENDER affirmation surgery, *COSMETIC dermatology, *CONSUMER behavior, *PATHOLOGICAL physiology, *SKIN aging
Abstract

This commentary examines the growing popularity of cosmetic procedures in men. With the recent increase in aesthetic procedures across the nation, it is important for physicians to understand trends as they evolve, which can help to optimize clinical training, business operations, and practice management. Although the popularity of cosmetic procedures in men has increased, available data on consumer behavior is limited. Our data fills this gap by examining the patterns of cosmetic procedures in men. Due to hormonal and anatomic differences, the pathophysiology of cutaneous aging differs between sexes, which can have significant implications for treatment. Our data demonstrates a positive trend in recent years and also breaks it down by individual procedures. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Erratum: Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Author

Kaur, Amanpreet, primary, Webster, Marie R., additional, Marchbank, Katie, additional, Behera, Reeti, additional, Ndoye, Abibatou, additional, Kugel, Curtis H., additional, Dang, Vanessa M., additional, Appleton, Jessica, additional, O’Connell, Michael P., additional, Cheng, Phil, additional, Valiga, Alexander A., additional, Morissette, Rachel, additional, McDonnell, Nazli B., additional, Ferrucci, Luigi, additional, Kossenkov, Andrew V., additional, Meeth, Katrina, additional, Tang, Hsin-Yao, additional, Yin, Xiangfan, additional, Wood, William H., additional, Lehrmann, Elin, additional, Becker, Kevin G., additional, Flaherty, Keith T., additional, Frederick, Dennie T., additional, Wargo, Jennifer A., additional, Cooper, Zachary A., additional, Tetzlaff, Michael T., additional, Hudgens, Courtney, additional, Aird, Katherine M., additional, Zhang, Rugang, additional, Xu, Xiaowei, additional, Liu, Qin, additional, Bartlett, Edmund, additional, Karakousis, Giorgos, additional, Eroglu, Zeynep, additional, Lo, Roger S., additional, Chan, Matthew, additional, Menzies, Alexander M., additional, Long, Georgina V., additional, Johnson, Douglas B., additional, Sosman, Jeffrey, additional, Schilling, Bastian, additional, Schadendorf, Dirk, additional, Speicher, David W., additional, Bosenberg, Marcus, additional, Ribas, Antoni, additional, and Weeraratna, Ashani T., additional

Published
2016
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29. Abstract A04: Aging microenvironment modulates melanoma invasion and metastasis

Author

Kaur, Amanpreet, primary, Marchbank, Katie, additional, Dang, Vanessa, additional, O'Connell, Michael, additional, Webster, Marie, additional, Appleton, Jessica, additional, Cheng, Phil, additional, Valiga, Alexander, additional, Morissette, Rachel, additional, McDonnell, Nazli, additional, Ferrucci, Luigi, additional, Kossenkov, Andrew, additional, Meeth, Katrina, additional, Bosenberg, Marcus, additional, Tang, Hsin-Yao, additional, Yin, Xiangfan, additional, Wood, William, additional, Lehrmann, Elin, additional, Becker, Kevin, additional, Flaherty, Keith, additional, Frederick, Dennie, additional, Wargo, Jennifer, additional, Aird, Katherine, additional, Zhang, Rugang, additional, Xu, Xiaowei, additional, Liu, Qin, additional, Speicher, David, additional, and Weeraratna, Ashani, additional

Published
2015
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30. Abstract B27: Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites

Author

Webster, Marie R., primary, Xu, Mai, additional, Kinzler, Kathryn, additional, Kaur, Amanpreet, additional, Appleton, Jessica, additional, O'Connell, Michael P., additional, Marchbank, Katie, additional, Valiga, Alexander, additional, Dang, Vanessa, additional, Perego, Michela, additional, Zhang, Gao, additional, Slipicevic, Ana, additional, Keeney, Frederick, additional, Lehrmann, Elin, additional, Wood, William, additional, Becker, Kevin, additional, Kossenkov, Andrew V., additional, Herlyn, Meenhard, additional, Murphy, Maureen, additional, and Weeraratna, Ashani T., additional

Published
2015
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31. Wnt5A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells

Author

Webster, Marie R., primary, Xu, Mai, additional, Kinzler, Kathryn A., additional, Kaur, Amanpreet, additional, Appleton, Jessica, additional, O'Connell, Michael P., additional, Marchbank, Katie, additional, Valiga, Alexander, additional, Dang, Vanessa M., additional, Perego, Michela, additional, Zhang, Gao, additional, Slipicevic, Ana, additional, Keeney, Frederick, additional, Lehrmann, Elin, additional, Wood, William, additional, Becker, Kevin G., additional, Kossenkov, Andrew V., additional, Frederick, Dennie T., additional, Flaherty, Keith T., additional, Xu, Xiaowei, additional, Herlyn, Meenhard, additional, Murphy, Maureen E., additional, and Weeraratna, Ashani T., additional

Published
2014
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32. Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Author

O'Connell, Michael P., primary, Marchbank, Katie, additional, Webster, Marie R., additional, Valiga, Alexander A., additional, Kaur, Amanpreet, additional, Vultur, Adina, additional, Li, Ling, additional, Herlyn, Meenhard, additional, Villanueva, Jessie, additional, Liu, Qin, additional, Yin, Xiangfan, additional, Widura, Sandy, additional, Nelson, Janelle, additional, Ruiz, Nivia, additional, Camilli, Tura C., additional, Indig, Fred E., additional, Flaherty, Keith T., additional, Wargo, Jennifer A., additional, Frederick, Dennie T., additional, Cooper, Zachary A., additional, Nair, Suresh, additional, Amaravadi, Ravi K., additional, Schuchter, Lynn M., additional, Karakousis, Giorgos C., additional, Xu, Wei, additional, Xu, Xiaowei, additional, and Weeraratna, Ashani T., additional

Published
2013
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33. Comparative Secretome Analysis of Epithelial and Mesenchymal Subpopulations of Head and Neck Squamous Cell Carcinoma Identifies S100A4 as a Potential Therapeutic Target

Author

Rasanen, Kati, primary, Sriswasdi, Sira, additional, Valiga, Alexander, additional, Tang, Hsin-Yao, additional, Zhang, Gao, additional, Perego, Michela, additional, Somasundaram, Rajasekharan, additional, Li, Ling, additional, Speicher, Kaye, additional, Klein-Szanto, Andres J., additional, Basu, Devraj, additional, Rustgi, Anil K., additional, Speicher, David W., additional, and Herlyn, Meenhard, additional

Published
2013
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34. Wnt5 A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.

Author

Webster, Marie R., Xu, Mai, Kinzler, Kathryn A., Kaur, Amanpreet, Appleton, Jessica, O'Connell, Michael P., Marchbank, Katie, Valiga, Alexander, Dang, Vanessa M., Perego, Michela, Zhang, Gao, Slipicevic, Ana, Keeney, Frederick, Lehrmann, Elin, Wood, William, Becker, Kevin G., Kossenkov, Andrew V., Frederick, Dennie T., Flaherty, Keith T., and Xu, Xiaowei

Subjects
ONCOGENES, MELANOMA, BIOMARKERS, OLD age, CANCER invasiveness, GENETICS
Abstract

We have previously shown that Wnt5 A drives invasion in melanoma. We have also shown that Wnt5 A promotes resistance to therapy designed to target the BRAFV600E mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5 A respond to therapeutic stress by increasing p21 and expressing classical markers of senescence, including positivity for senescence-associated β-galactosidase ( SA- β-gal), senescence-associated heterochromatic foci ( SAHF), H3 K9 Me chromatin marks, and PML bodies. We find that despite this, these cells retain their ability to migrate and invade. Further, despite the expression of classic markers of senescence such as SA- β-gal and SAHF, these Wnt5 A-high cells are able to colonize the lungs in in vivo tail vein colony-forming assays. This clearly underscores the fact that these markers do not indicate true senescence in these cells, but instead an adaptive stress response that allows the cells to evade therapy and invade. Notably, silencing Wnt5 A reduces expression of these markers and decreases invasiveness. The combined data point to Wnt5 A as a master regulator of an adaptive stress response in melanoma, which may contribute to therapy resistance. [ABSTRACT FROM AUTHOR]

Published
2015
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35. X-Linked Ichthyosis.

Author

Valiga, Alexander A., Forrester, Vernon, and Wilson, Barbara B.

Published
2019

36. Enlarging nodule on the thigh.

Author

Valiga AA, Grandhi R, and Tjarks BJ

Subjects
Adenocarcinoma secondary, Aged, Diagnosis, Differential, Humans, Immunohistochemistry, Skin Neoplasms secondary, Thigh, Adenocarcinoma diagnosis, Adenocarcinoma pathology, Colonic Neoplasms pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology
Published
2019

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