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Background: To adapt quickly to changes in the environment, significant functional changes occur in the human body exposed to various negative factors (including extreme occupational stress). The endocrine system, with the activation of the sympathoadrenal and pituitary-adrenocortical axis, plays an important role in this process. The aim of our investigation was to study the features of interhormonal relationships between the sympathoadrenal and pituitary-adrenocortical axis and the thyroid and gonadal hormones among professional, at-risk staff. Materials and Methods: A total of 156 police officers stationed in the Archangelsk region were examined. Depending on their professional activity, 3 groups were formed. Group 1 included 48 police officers who were sent to the conflict regions to maintain law enforcement – combatants. Group 2 included 52 duty officers who had never been in a territory with military conflict. Group 3 was formed from 56 students of the Police Training Center. Spearman’s rank correlation coefficient was calculated to measure the strength and direction of the relationship between two variables. Results: Among the studied groups of police officers, we found that the severity of interhormonal correlation depended on the intensity of professional activity. The highest number of significant interhormonal correlations was registered in the group of combatants, and these correlations were recorded between the hormones of all parts of the endocrine system: pituitarysympathoadrenal and thyroid-gonad hormones. Conclusion: The revealed multiple significant intersystem hormonal correlations among combatants, as compared with duty and student policemen, indicate that the functional intensity of the endocrine system is due to the extreme state of the professional environment.

At the present time occur a lot of political, ideological, religion, economic crises and other conflicts that lead to global changes of social sphere. The frequent cases of local armed conflict, terrorism act takes a considerable mobilization of economic and human resources. As a rule, the professional members of a police task force occupation for maintain securities are with extreme environments. The occupational hazard effect may evident by overstrain and depletion of functional regulatory mechanisms that provide the adaptation. The law-enforcement officers of Ministry of Home Affairs, aged 23-35 years were investigated. In according to professional occupation this one was divided in three groups: combatants that send on a mission to Caucasus for maintenance of law order; law-enforcement school students; policemen that maintain law order in territory without war conflict and never take part in combat mission. The blood serum steroid hormones (cortisol, testosterone, progesterone and estradiol) were determined. It was provided comparative analysis of means between groups: combatants before – after mission; combatant – students – policemen. Analyses of our results are shown that hormonal levels at all persons were in normal physiological limits. Together with it, significant differences of steroid serum hormonal means between comparative groups as for dependent samples well as for independent samples were revealed. The differences of endocrine system index (hormonal levels of steroid hormones) at different law-enforcement officer groups with intensive professional stress are reactions for adaptation of organism to extreme factors, probably. They provide optimal adaptive changes to response on environment stress.