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1. Management of immunosuppressive therapy in kidney transplant recipients with COVID-19. A multicentre national study derived from the Spanish Society of Nephrology COVID registry

Author

López-Oliva, María O., Pérez-Flores, Isabel, Molina, María, José Aladrén, María, Trujillo, Hernando, Redondo-Pachón, Dolores, López, Verónica, Facundo, Carme, Villanego, Florentino, Rodríguez, Marisa, Carmen Ruiz, Maria, Antón, Paula, Rivas-Oural, Alba, Cabello, Sheila, Portolés, José, de la Vara, Lourdes, Tabernero, Guadalupe, Valero, Rosalía, Galeano, Cristina, Moral, Esperanza, Ventura, Ana, Coca, Armando, Ángel Muñoz, Miguel, Hernández-Gallego, Román, Shabaka, Amir, Ledesma, Gabriel, Bouarich, Hanane, Ángeles Rodríguez, María, Pérez Tamajón, Lourdes, Cruzado, Leónidas, Emilio Sánchez, José, and Jiménez, Carlos

Published
2023
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2. Manejo de la inmunosupresión en pacientes trasplantados de riñón con COVID19. Estudio multicéntrico nacional derivado del registro COVID de la Sociedad Española de Nefrología

Author

López-Oliva, María O., Pérez-Flores, Isabel, Molina, María, Aladrén, M. José, Trujillo, Hernando, Redondo-Pachón, Dolores, López, Verónica, Facundo, Carme, Villanego, Florentino, Rodríguez, Marisa, Ruiz, M. Carmen, Antón, Paula, Rivas-Oural, Alba, Cabello, Sheila, Portolés, José, de la Vara, Lourdes, Tabernero, Guadalupe, Valero, Rosalía, Galeano, Cristina, Moral, Esperanza, Ventura, Ana, Coca, Armando, Muñoz, Miguel Ángel, Hernández-Gallego, Román, Shabaka, Amir, Ledesma, Gabriel, Bouarich, Hanane, Rodríguez, M. Ángeles, Pérez Tamajón, Lourdes, Cruzado, Leónidas, Sánchez, J. Emilio, and Jiménez, Carlos

Published
2023
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5. #2120 Impact on CKD classification and comorbidities using GFR estimated by European Kidney Function Consortium equation in kidney transplant recipients

Author

Belotto, Miguel Martínez, primary, Ortega, María José, additional, Rodríguez, María, additional, Escagedo, Clara, additional, Pasache, José Enrique, additional, García, Cristina, additional, Valero, Rosalía, additional, López del Moral, Covadonga, additional, Belmar, Lara, additional, de la Oliva Valentín, María, additional, Ruiz, Juan Carlos, additional, and Rodrigo, Emilio, additional

Published
2024
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6. #466 Comparison of CKDEPI vs EKFC equations in estimating glomerular filtration rate in kidney transplant recipients

Author

Belotto, Miguel Martínez, primary, Ortega, María José, additional, Rodríguez, María, additional, Escagedo, Clara, additional, García, Cristina, additional, Pasache, José Enrique, additional, López del Moral, Covadonga, additional, Valero, Rosalía, additional, Belmar, Lara, additional, de la Oliva Valentín, María, additional, Ruiz, Juan Carlos, additional, and Rodrigo, Emilio, additional

Published
2024
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8. Donor-Derived Cell-Free DNA at 1 Month after Kidney Transplantation Relates to HLA Class II Eplet Mismatch Load

Author

González-López, Elena, primary, Ocejo-Vinyals, Javier Gonzalo, additional, Renuncio-García, Mónica, additional, Roa-Bautista, Adriel, additional, San Segundo Arribas, David, additional, Escagedo, Clara, additional, García-Saiz, María del Mar, additional, Valero, Rosalía, additional, García-Berbel, Pilar, additional, Ruíz San Millán, Juan Carlos, additional, and Rodrigo, Emilio, additional

Published
2023
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9. Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study)

Author

Pérez-Sáez, María José, Lafuente Covarrubias, Omar, Hernández, Domingo, Moreso, Francesc, Melilli, Edoardo, Juega, Javier, de Sousa, Erika, López-Sánchez, Paula, Rodríguez-Ferrero, María Luisa, Maruri-Kareaga, Naroa, Navarro, María Dolores, Valero, Rosalía, Mazuecos, María Auxiliadora, Llamas, Francisco, Martín-Moreno, Paloma, Fernández-García, Antón, Espí, Jordi, Jiménez, Carlos, Ramos, Ana, Gavela, Eva, Pascual, Julio, Portolés, Jose M., and on behalf of the GEODAS Group

Published
2019
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10. Torque Teno Virus Load Predicts Opportunistic Infections after Kidney Transplantation but Is Not Associated with Maintenance Immunosuppression Exposure

Author

Cañamero, Lucía, primary, Benito-Hernández, Adalberto, additional, González, Elena, additional, Escagedo, Clara, additional, Rodríguez-Vidriales, María, additional, García-Saiz, María del Mar, additional, Valero, Rosalía, additional, Belmar, Lara, additional, de Cos, María Angeles, additional, Francia, María Victoria, additional, Ruiz, Juan Carlos, additional, and Rodrigo, Emilio, additional

Published
2023
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12. Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion Does Not Increase Graft Fibrosis in the First Year Posttransplant Surveillance Biopsy

Author

Barreda, Paloma, primary, Miñambres, Eduardo, additional, Ballesteros, María Ángeles, additional, Mazón, Jaime, additional, Gómez-Román, Javier, additional, Gómez Ortega, José María, additional, Belmar, Lara, additional, Valero, Rosalía, additional, Ruiz, Juan Carlos, additional, and Rodrigo, Emilio, additional

Published
2022
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13. Manejo de la inmunosupresión en pacientes trasplantados de riñón con COVID19. Estudio multicéntrico nacional derivado del registro COVID de la S.E.N

Author

López-Oliva, María O., primary, Pérez-Flores, Isabel, additional, Molina, María, additional, José Aladrén, Mª, additional, Trujillo, Hernando, additional, Redondo-Pachón, Dolores, additional, López, Verónica, additional, Facundo, Carme, additional, Villanego, Florentino, additional, Rodríguez, Marisa, additional, Carmen Ruiz, Mª, additional, Antón, Paula, additional, Rivas-Oural, Alba, additional, Cabello, Sheila, additional, Portolés, José, additional, de la Vara, Lourdes, additional, Tabernero, Guadalupe, additional, Valero, Rosalía, additional, Galeano, Cristina, additional, Moral, Esperanza, additional, Ventura, Ana, additional, Coca, Armando, additional, Muñoz, Miguel Ángel, additional, Hernández-Gallego, Román, additional, Shabaka, Amir, additional, Ledesma, Gabriel, additional, Martínez, Patricia, additional, Ángeles Rodríguez, Mª, additional, Tamajón, Lourdes Pérez, additional, Cruzado, Leónidas, additional, Emilio Sánchez, J., additional, and Jiménez, Carlos, additional

Published
2022
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14. Recurrence of immune complex and complement-mediated membranoproliferative glomerulonephritis in kidney transplantation.

Author

Caravaca-Fontán, Fernando, Polanco, Natalia, Villacorta, Blanca, Buxeda, Anna, Coca, Armando, Ávila, Ana, Martínez-Gallardo, Rocío, Galeano, Cristina, Valero, Rosalía, Ramos, Natalia, Allende, Natalia, Cruzado-Vega, Leónidas, Pérez-Sáez, María José, Sevillano, Ángel, González, Esther, Hernández, Ana, Rodrigo, Emilio, Fernández-Ruiz, Mario, Aguado, José María, and Valdivia, Miguel Ángel Pérez

Subjects
KIDNEY transplantation, IMMUNE complexes, GLOMERULONEPHRITIS, KIDNEY diseases, DISEASE remission, NEPHRITIS, KIDNEY failure
Abstract

Introduction Membranoproliferative glomerulonephritis (MPGN) represents a histologic pattern of glomerular injury that may be due to several aetiologies. Few studies have comprehensively analysed the recurrence of MPGN according to the current classification system. Methods We collected a multicentre, retrospective cohort of 220 kidney graft recipients with biopsy-proven native kidney disease due to MPGN between 1981 and 2021 in 11 hospitals. Demographic, clinical and histologic parameters of prognostic interest were collected. The main outcomes were time to kidney failure, time to recurrence of MPGN and disease remission after recurrence. Results The study group included 34 complement-mediated and 186 immune complex–mediated MPGN. A total of 81 patients (37%) reached kidney failure in a median follow-up of 79 months. The main predictors of this event were the development of rejection episodes and disease recurrence. In all, 54 patients (25%) had a disease recurrence in a median of 16 months after kidney transplantation. The incidence of recurrence was higher in patients with dysproteinaemia (67%) and complement-mediated MPGN (62%). In the multivariable model, complement-mediated MPGN emerged as a predictor of recurrence. A total of 33 patients reached kidney failure after recurrence. The main determinants of no remission were early time to recurrence (<15 months), estimated glomerular filtration rate <30 mL/min/1.73 m2 and serum albumin <3.5 g/dL at the time of recurrence. Conclusions One-fourth of the patients with native kidney disease due to MPGN developed clinical recurrence in the allograft, especially in cases with complement-mediated disease or in those associated with dysproteinaemia. The kidney outcomes of disease recurrence with currently available therapies are heterogeneous and thus more effective and individualized therapies are needed. [ABSTRACT FROM AUTHOR]

Published
2023
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15. MO013PATERNAL SAFETY OF THE USE OF MYCOPHENOLIC ACID BY KIDNEY TRANSPLANT RECIPIENTS. RESULTS OF THE EMVARON STUDY

Author

Armando Coca, Ana González-Rinne, Paloma L Martin-Moreno, Mónica Pérez-Mir, Valero Rosalía, Ana Sánchez-Fructuoso, Carlos Jiménez, Marisa Mir, Isabel María López López, Ana Ventura Galiano, Leónidas Cruzado-Vega, Auxiliadora Mazuecos, Natalia Ridao, Ernesto José Fernández-Tagarro, and Nestor Toapanta

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Urology, business, Kidney transplant, Mycophenolic acid, medicine.drug
Abstract

Background and Aims Mycophenolic acid (MPA) is one of the most used immunosuppressive drugs. It is teratogenic in women with a typical embryopathy profile. Regarding its effect on the children of male kidney transplant recipients, although clinical evidence does not indicate a greater risk of malformations, the European Medicines Agency and the Spanish Agency for Medicines and Health Products introduced in 2015 the recommendation to use contraceptive methods because of their genotoxic potential. For this reason, we propose to study the results of the Spanish Kidney Transplant Centers. Method Multicenter retrospective observational study in which 15 Kidney Transplant Centers have participated. Of 3934 men ≤ 60 years old that received a kidney transplant between 2000 and 2015, 3023 were contacted, and 159 men who fathered at least one post-transplant pregnancy (total 252 fetuses) were included. We compared the incidence of abortions and live births with malformations among those who received MPA at the time of conception vs. those who did not. Results In the 252 fetuses (characteristics in table 1) there was an exitus and no differences were detected in the incidence of abortions between the group exposed to MPA (n = 230) and the unexposed group (n = 22), 11.3% vs 18.2%, p = 0.31. Among the 221 live-born fetuses, no differences were found in congenital malformations between the group exposed to MPA (n = 203) and the unexposed (n = 18) 4.9% vs. 16.7%, p = 0.07. Among the malformations described, the typical embryopathy profile of the MPA was not found. Conclusion According to the data of this retrospective national multicenter study, the use of MPA in male kidney transplant recipients does not cause a greater number of abortions or congenital malformations. For these reasons, and given the evidence also published by other groups, it seems necessary to reevaluate the recommendation given on contraception in men treated with MPA.

Published
2020
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18. Paternal safety of the use of mycophenolic acid in kidney transplant recipients. Results of the EMVARON study

Author

Martin‐Moreno, Paloma L., primary, Sánchez‐Fructuoso, Ana I., additional, Mazuecos, Auxiliadora, additional, Mir, Marisa, additional, Lopez‐Lopez, Isabel, additional, González‐Rinne, Ana, additional, Coca, Armando, additional, Valero, Rosalía, additional, Ventura Galiano, Ana, additional, Ridao, Natalia, additional, Toapanta‐Gaibor, Nestor G., additional, Fernández‐Tagarro, Ernesto, additional, Cruzado‐Vega, Leonidas, additional, Pérez‐Mir, Mónica, additional, and Jiménez, Carlos, additional

Published
2021
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24. New-Onset Diabetes after Kidney Transplantation

Author

Rodrigo, Emilio, primary, Fernández-Fresnedo, Gema, additional, Valero, Rosalía, additional, Ruiz, Juan Carlos, additional, Piñera, Celestino, additional, Palomar, Rosa, additional, González-Cotorruelo, Julio, additional, Gómez-Alamillo, Carlos, additional, and Arias, Manuel, additional

Published
2006
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