1. Solid herbal extract of Primula veris L. improves morphofunctional condition of rats’ myocardium in chronic alcohol intoxication
- Author
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Igor I. Prokofiev, Margarita V. Kustova, Alla A. Nesterova, Valentina N. Perfilova, Gulnara H. Khusainova, Ludmila E. Borodkina, Yakov V. Tivon, Ivan N. Tyurenkov, Valeri A. Kataev, and Gusel M. Latypova
- Subjects
Alcohol ,Heart ,Mitochondria ,Primula veris ,Flavones ,Medicine - Abstract
Background and aim: Chronic alcohol intoxication (CAI) induces heart damage. One of the promising ways of its treatment involves the administration of herbal medicinal products. The purpose of this study was to explore the effect of solid herbal extract of Primula veris L. (PVSHE) on the morphofunctional changes in rats’ myocardium after CAI. Experimental procedure: CAI was simulated for 24 weeks. Loading testing was used to assess the functional condition of the heart, the functional assessment of mitochondria was based on the polarographic determination of oxygen consumption rate and determination of the indices of lipid peroxidation and antioxidant enzymes activity. We performed a microscopic examination of the left ventricle following the standard protocol of histological processing and h&e staining. Results and conclusion: PVSHE restricts the toxic effects of ethanol on the heart which was indicated by a higher rise in the rates of myocardial contraction (by an average of 3.9 times, P
- Published
- 2023
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