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A stochastic approach for modeling and analysing the transients due to the users’ water consumptions in a real water distribution system is presented. The analysis is based on field measure...

This paper analyses the propagation and mechanisms of interaction of a pressure wave in a looped water distribution network by means of laboratory and numerical tests. Transients are generated by the complete and fast closure of a valve, simulating an end-user maneuver, located at the downstream end section of a service line. The adequate length of the service line allows capturing each single pressure wave inserted into the network. The executed tests and successive analysis by means of a Lagrangian model (LM) highlight the effect of the network topology and the location of the transient generation point but in a more expeditious way with respect to the use of a complete transient model. The most excited part of the system is the one in close proximity of the end-user and then the corresponding service line. Within the network, pressure waves accumulate in the areas with the smallest diameter pipes. By means of the refined LM—which is able to capture the pressure extreme values occurring in the first phases of the transient—the vulnerability maps of the network are provided. Such maps identify the nodes subjected to the most severe pressure waves in terms of both frequency and amplitude. The exposure level to transients of each node is synthesized by the value of the vulnerability index proposed in this paper.

The growth of tourism in the last decades has left behind a significant footprint on water resources, which is particularly evident in the regions affected by water scarcity or consistent seasonal population fluctuations. However, only limited efforts were spent in evaluating the effects of tourism on water consumption with regard to specific non-residential users such as bathing facilities. The current work aimed at providing an insight into the effects of seaside tourism on water consumption in a case study coastal area in northern Italy that is typically subjected to high tourist fluctuations throughout the year. Analyses were carried out at multiple spatiotemporal scales—from urban to user level, and from yearly to daily scale—by exploiting hourly flow data collected at the inflow points of the area and at some touristic users (i.e. nine bathing facilities and a holiday home). In addition, the impact of weather—temperature and rainfall—on water use was explored. The study revealed consistent inflow fluctuations in the area concerned based on tourism (with a ratio between the maximum and minimum monthly average inflow of about 15.7) and demonstrated that the touristic component of water inflow was considerably higher than the residential component at the height of tourist season (i.e., 176 L/s against 42 L/s). Moreover, significant variations in the water inflow due to tourism and weather were also observed on a daily scale, along with considerable water consumption fluctuations in bathing facilities.

This paper presents the results of the monitoring and analysis of the dynamic behaviour of the Gorino Ferrarese (Ferrara, Italy) water distribution system. The network is subjected to ordinary oper...

The effectiveness of pressure-reducing valves (PRVs) for optimal pressure management of water distribution networks (WDNs) is proven, but problems and operational limitations have been highlighted by some recent experiences. In this study, we analyse the functioning of a piston-actuated pressure-reducing valve (PA-PRV) with a mechanical pilot which is subjected to low-flow regimes, a condition that is often observed in real water distribution networks. The analyses were carried out by means of laboratory tests featuring two sets of experiments, i.e., (a) by testing the behaviour of the PRV when a pre-established initial value and subsequent variation of flow rate occurs in the system and (b) by testing the PRV against a temporal series of flow rates observed at the inlet section of a real district metered area. The first set of tests showed that the PA-PRV tends not to maintain pressure at the imposed set-point and exhibits an unstable behaviour characterised by significant pressure oscillations under some flow rate conditions. The second set of laboratory tests showed that the anomalous behaviour identified in the first set of tests can occur under ordinary operational conditions of a network.

Rasd2 is a thyroid hormone target gene, which encodes for a GTP-binding protein enriched in the striatum where, among other functions, it modulates dopaminergic neurotransmission. Here we report that human RASD2 mRNA is abundant in putamen, but it also occurs in the cerebral cortex, with a distinctive expression pattern that differs from that present in rodents. Consistent with its localization, we found that a genetic variation in RASD2 (rs6518956) affects postmortem prefrontal mRNA expression in healthy humans and is associated with phenotypes of relevance to schizophrenia, including prefrontal and striatal grey matter volume and physiology during working memory, as measured with magnetic resonance imaging. Interestingly, quantitative real-time PCR analysis indicated that RASD2 mRNA is slightly reduced in postmortem prefrontal cortex of patients with schizophrenia. In the attempt to uncover the neurobiological substrates associated with Rasd2 activity, we used knockout mice to analyze the in vivo influence of this G-protein on the prepulse inhibition of the startle response and psychotomimetic drug-related behavioral response. Data showed that Rasd2 mutants display deficits in basal prepulse inhibition that, in turn, exacerbate gating disruption under psychotomimetic drug challenge. Furthermore, we documented that lack of Rasd2 strikingly enhances the behavioral sensitivity to motor stimulation elicited by amphetamine and phencyclidine. Based on animal model data, along with the finding that RASD2 influences prefronto-striatal phenotypes in healthy humans, we suggest that genetic mutation or reduced levels of this G-protein might have a role in cerebral circuitry dysfunction underpinning exaggerated psychotomimetic drugs responses and development of specific biological phenotypes linked to schizophrenia.

Background Rasd2 is a striatal GTP-binding protein that modulates Akt and mTOR signaling cascades, well known to be highly vulnerable pathways in psychiatric disorders. Aims We investigated the association of Rasd2 and its genetic variation with a series of prefronto-striatal phenotypes related to psychosis in rodents and humans. Objectives We want to provide evidence that Rasd2 controls the vulnerability to schizophrenia-related behavior induced by psychothomimetic drugs in mice. Moreover, we aim to find genetic variations within the Rasd2 gene that influence a series of brain schizophrenia-related phenotypes in human. Methods Rasd2 knockout mice were employed to evaluate schizophrenia-like behaviors induced by psychotomimetic drugs like amphetamine and phencyclidine. Furthermore, we investigated if RASD2 genetic variations in humans are associated with mRNA expression in post-mortem prefrontal cortex, as well as prefrontal and striatal grey matter volume and physiology during working memory as measured with MRI in healthy subjects. Finally, we assessed RASD2 mRNA expression levels in post-mortem brains of patients with schizophrenia and bipolar disorder. Results We found that both psychotomimetics triggered greater vulnerability to motor stimulation and to prepulse inhibition deficits in Rasd2 mutants. In humans, we found that a genetic variation (rs6518956) within RASD2 predicts prefrontal mRNA expression as well as prefrontal grey matter volume and prefronto-striatal activity during working memory. Finally, we reported that RASD2 mRNA expression is slightly reduced in post-mortem prefrontal cortex of patients with schizophrenia. Conclusions Collectively, our data suggests that RASD2 represents a gene of potential interest in psychiatric disorders for its ability to modulate prefronto-striatal phenotypes related to schizophrenia.