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Introducción. Los tricobezoares ocurren de forma frecuente en niñas y adolescentes, y se asocian a trastornos psicológicos como depresión, tricotilomanía o tricofagia. Caso clínico. Se presenta una paciente adolescente con síndrome de Rapunzel, con hallazgo adicional de perforación yeyunal debido al tricobezoar. Discusión. Dentro de las complicaciones de los tricobezoares se reporta invaginación intestinal (principalmente de yeyuno), apendicitis, obstrucción biliar, neumonía, pancreatitis secundaria y perforación, esta última como ocurrió en nuestra paciente. Conclusión. En pacientes mujeres adolescentes con dolor abdominal o abdomen agudo, se debe tener en cuenta el diagnóstico de síndrome de Rapunzel, así como sus probables complicaciones.

El objetivo de esta investigación es analizar los usos de Facebook por parte de mujeres en duelo por muerte para recordar a sus seres queridos fallecidos. El diseño fue cualitativo y el método, fenomenológico-hermenéutico. Se entrevistó a 29 mujeres adultas en proceso de duelo. Se halló que la función de “recuerdos” de Facebook genera emociones como la tristeza y la rabia durante los primeros momentos del duelo; esto se debe a que el algoritmo de la red social define los contenidos que aparecen sobre el fallecido. No obstante, en momentos posteriores del duelo, dicha función produce alegría porque ayuda a mantener viva la memoria sobre los fallecidos, no solo para las dolientes, sino para el amplio número de contactos y seguidores de la red social. Por otra parte, el uso de tecnologías digitales mantiene diversos registros de las personas (mensajes, fotografías, videos, etc.), los cuales son utilizados por las dolientes para construir perfiles conmemorativos que son permanente actualizados. Entonces, una experiencia como el duelo, que antes se consideraba privada e íntima, ahora se expresa y experimenta públicamente en escenarios digitales.

En el siguiente artículo ofrecemos algunas reflexiones derivadas de un proceso de investigación en torno a las capacidades políticas para las transiciones en los territorios afectados por el conflicto armado colombiano. Estas reflexiones se refieren a una lectura de la acción comunitaria de las organizaciones de víctimas de Samaná (Caldas, Colombia) a partir de la hermenéutica fenomenológica de Paul Ricoeur. Así hemos llegado a identificar tres símbolos para una lectura de la acción comunitaria: el sujeto víctima que se ha convertido en sujeto superviviente; la emergencia de la alteridad no hegemónica; y el yo como otro. Conclusión: la vida de los sujetos víctimas asociados a este tipo de organizaciones está mediada por la acción comunitaria y sus respectivas narrativas.

Trophoblast cells are often compared to highly invasive carcinoma cells due to their capacity to proliferate in hypoxic conditions and to exhibit analogous vascular, proliferative, migratory, and invasive capacities. Thus, genes that are important for tumorigenesis, such as forkhead box M1 ( FOXM1) may also be involved in processes of trophoblast invasion. Indeed, we found Foxm1 protein and messenger RNA (mRNA) levels decreased as gestational age increased in rat's placentae. Accordingly, when mimicking early placental events in vitro, protein and mRNA expression of FOXM1 increased from 21% to 8% O2, reaching its highest expression at 3% oxygen tension, which reflects early implantation environment, and dropping to very low levels at 1% O2. Remarkably, FOXM1 silencing in JEG-3 cells was able to significantly decrease migration by 27.9%, in comparison with those cells transfected with control siRNA. Moreover, angiogenesis was compromised when conditioned media (CM) from FOXM1-siRNA -JEG-3 (3% O2) was added to human umbilical vein endothelial cells (HUVEC) cells; however, when CM of JEG-3 cells overexpressing FOXM1 at 1% O2 was added, the ability of HUVEC to form tubule networks was restored. Additionally, quantitative real-time polymerase chain reaction (PCR) assays of FOXM1 knockdown and overexpression experiments in JEG-3 cells revealed that the depletion of FOXM1 at 3% O2 and overexpression of FOXM1 at 1% O2 led to downregulation and upregulation of vascular endothelial growth factor transcriptional (VEGF) levels, respectively. Conversely, we also observed deregulation of FOXM1 in placentae derived from pregnancies complicated by preeclampsia (PE). Therefore, we demonstrate that FOXM1 may be a new regulatory protein of early placentation processes and that under chronic hypoxic conditions (1% O2) and in patients with severe PE, its levels decrease.

The academic community of the department of Risaralda, in its permanent interest in evidencing the results of the research processes that are carried out from the Higher Education Institutions and as a product of the VI meeting of researchers of the department of Risaralda held in November 2021 presents its work: “The journey of research as a challenge towards new trends”, which reflects the result of the latest research and advances in different lines of knowledge in Agricultural Sciences, Health Sciences, Social Sciences and Technology and Information Sciences, which seek to solve and meet the demands of the different sectors. This work would not have been possible without the help of each of the teachers, researchers and authors who presented their articles that make up each of the chapters of the book, to them our gratitude for their commitment, dedication and commitment, since their sole purpose is to contribute from the academy and science to scientific and technological development in the search for the solution of problems and thus contribute to transform the reality of our society and communities. We also wish to extend our gratitude to the institutions of the Network that made this publication possible: UTP, UCP, UNAD, UNIREMINGTON; UNISARC, CIAF, Universidad Libre, Uniclaretiana, Fundación Universitaria Comfamiliar and UNIMINUTO, institutions that in one way or another allowed this work to become a reality, which we hope will be of interest to you. Preface............................................................................................................................7 Chapter 1. Technologies and Engineering Towards a humanization in Engineering using soft skills in training in Engineers.............................................................................................................11 Omar Iván Trejos Buriticá1, Luis Eduardo Muñoz Guerrero Innovative materials in construction: review from a bibliometric analysis....................................................................................................................27 Cristian Osorio Gómez, Daniel Aristizábal Torres, Alejandro Alzate Buitrago, Cristhian Camilo Amariles López Bibliometric review of disaster risk management: progress, trends, and challenges.........................................................................................................51 Alejandro Alzate Buitrago, Gloria Milena Molina Vinasco. Incidence of land coverage and geology, in the unstability of lands of the micro-basin of the Combia creek, Pereira, Risaralda....................................73 Alejandro Alzate Buitrago, Daniel Aristizábal Torres. Chapter 2. Arts, Humanities, and Social Sciences Training experience with teachers teaching mathematics using the inquiry methodology ...............................................................................................95 Vivian Libeth Uzuriaga López, Héctor Gerardo Sánchez Bedoya. Interpretation of the multiple representations of the fears associated to the boarding of limited visual patients in the elective I students’ written productions and low vision ...................................................................................113 Eliana Bermúdez Cardona, Ana María Agudelo Guevara, Caterine Villamarín Acosta. The relevance of local knowledge in social sciences............................................131 Alberto Antonio Berón Ospina, Isabel Cristina Castillo Quintero. Basic education students’ conceptions of conflict a view from the peace for the education....................................................................................................143 Astrid Milena Calderón Cárdenas,Carolina Aguirre Arias, Carolina Franco Ossa, Martha Cecilia Gutiérrez Giraldo, Orfa Buitrago. Comprehensive risk prevention in educational settings: an interdisciplinary and socio-educational approach ............................................................................163 Olga María Henao Trujillo, Claudia María López Ortiz. Chapter 3. Natural and Agricultural Sciences Physicochemical characterization of three substrates used in the deep bedding system in swine .......................................................................................175 Juan Manuel Sánchez Rubio, Andrés Felipe Arias Roldan, Jesús Arturo Rincón Sanz, Jaime Andrés Betancourt Vásquez. Periodic solutions in AFM models........................................................................187 Daniel Cortés Zapata, Alexander Gutiérrez Gutiérrez. Phenology in flower and fruit of Rubus glaucus benth. Cv. Thornless in Risaralda: elements for phytosanitary management .........................................199 Shirley Palacios Castro, Andrés Alfonso Patiño Martínez, James Montoya Lerma, Ricardo Flórez, Harry Josué Pérez. Socio-economic and technical characterization of the cultivation of avocado (Persea americana) in Risaralda..............................................................217 Andrés Alfonso Patiño Martínez, Kelly Saudith Castañez Poveda, Eliana Gómez Correa. Biosecurity management in backyard systems in Santa Rosa de Cabal, Risaralda................................................................................................................227 Julia Victoria Arredondo Botero, Jaiver Estiben Ocampo Jaramillo, Juan Sebastián Mera Vallejo, Álvaro de Jesús Aranzazu Hernández. CONTENTS Physical-chemical diagnosis of soils in hillside areas with predominance of Lulo CV. La Selva production system in the department of Risaralda.............241 Adriana Patricia Restrepo Gallón, María Paula Landinez Montes, Jimena Tobón López. Digestibility of three concentrates used in canine feeding....................................271 María Fernanda Mejía Silva, Valentina Noreña Sánchez, Gastón Adolfo Castaño Jiménez. Chapter 4. Economic, Administrative, and Accounting Sciences Financial inclusion in households from socioeconomic strata 1 and 2 in the city of Pereira ..................................................................................................285 Lindy Neth Perea Mosquera, Marlen Isabel Redondo Ramírez, Angélica Viviana Morales. Internal marketing strategies as a competitive advantage for the company Mobilautos SAS de Dosquebradas........................................................................303 Inés Montoya Sánchez, Sandra Patricia Viana Bolaños, Ana María Barrera Rodríguez. Uses of tourist marketing in the tourist sector of the municipality of Belén de Umbría, Risaralda.............................................................................................319 Ana María Barrera Rodríguez, Paola Andrea Echeverri Gutiérrez, María Camila Parra Buitrago, Paola Andrea Martín Muñoz, Angy Paola Ángel Vélez, Luisa Natalia Trejos Ospina. Territorial prospective of Risaralda department (Colombia), based on the SDGS...............................................................................................................333 Juan Guillermo Gil García, Samanta Londoño Velásquez. Chapter 5. Health and Sports Sciences Performance evaluation in times of pandemic. What do medical students think?.......................................................................................................353 Samuel Eduardo Trujillo Henao, Rodolfo A. Cabrales Vega, Germán Alberto Moreno Gómez. The relevance of the therapist’s self and self-reference in the training of psychologists.....................................................................................................371 Maria Paula Marmolejo Lozano, Mireya Ospina Botero. Habits related to oral health which influence lifestyle of elder people in a wellness center for the elderly in Pereira 2020. .............................................387 Isadora Blanco Pérez, Olga Patricia Ramírez Rodríguez, Ángela María Rincón Hurtado. Analysis of the suicide trend in the Coffee Region in Colombia during the years 2012-2018 ..............................................................................................405 Germán Alberto Moreno Gómez, Jennifer Nessim Salazar, Jairo Franco Londoño, Juan Carlos Medina Osorio. Hind limb long bone fractures in canines and felines...........................................419 María Camila Cruz Vélez, Valentina Herrera Morales, Alba Nydia Restrepo Jiménez, Lina Marcela Palomino, Gabriel Rodolfo Izquierdo Bravo. Prevalence of overweight and obesity in children in the rural and urban area of Risaralda....................................................................................................439 Angela María Álvarez López, Angela Liceth Pérez Rendón, Alejandro Gómez Rodas, Luis Enrique Isaza Velásquez. Chapter 6. Architecture, Design and Advertising The artisan crafts of Risaralda, characteristics, importance, and risks within the Colombian Coffee Cultural Landscape, CCCL....................................457 Yaffa Nahir Ivette Gómez Barrera, Javier Alfonso López Morales.

RESUMEN. El cyberbullying es un problema creciente, sobre todo entre la población adolescente. Este fenómeno amerita investigación científica que apunte a explicarlo en el mayor número de aspectos posibles, incluyendo las emociones. En este marco, la presente investigación se ocupa de analizar la ira en adolescentes involucrados en situaciones de cyberbullying. Se realizó un estudio con diseño cualitativo y método fenomenológico-hermenéutico, en el que se entrevistaron 31 adolescentes entre los 12 y 17 años de edad, implicados en situaciones de cyberbullying en los roles de víctimas o espectadores. Las víctimas de ciberacoso sienten ira, especialmente, cuando las agresiones provienen de parte de personas a quienes consideraban sus amigos. Esta emoción se experimenta junto con otros afectos como la tristeza y la vergüenza. Para los espectadores, la ira está asociada a situaciones de injusticia y a la percepción de que los agresores no tienen empatía hacia las víctimas. Los adolescentes reconocen los efectos negativos que el cyberbullying tiene sobre la imagen de las personas en entornos digitales. Comprender el lugar que ocupan las emociones en las agresiones mediadas por TIC es fundamental para generar conocimiento que sirva de base para el diseño e implementación de programas de intervención psicosocial del ciberacoso, y promover espacios de reflexión sobre de lo que significa la intimidad, la amistad y la confianza en la era digital. RESUMO. O cyberbullying é um problema crescente, especialmente entre a população adolescente. Esse fenômeno merece pesquisas científicas que visam explicá-lo no maior número possível de aspectos, incluindo emoções. Dentro dessa estrutura, a presente investigação se preocupa em analisar a raiva em adolescentes envolvidos em situações de cyberbullying. Foi realizado um estudo com desenho qualitativo e método fenomenológico-hermenêutico, no qual foram entrevistados 31 adolescentes entre 12 e 17 anos de idade, envolvidos em situações de cyberbullying no papel de vítimas ou espectadores. As vítimas do cyberbullying sentem raiva, principalmente quando os ataques são de pessoas que consideram amigas. Essa emoção é experimentada junto com outros afetos, como tristeza e vergonha. Para os espectadores, a raiva está associada a situações de injustiça e à percepção de que os agressores não têm empatia pelas vítimas. Os adolescentes reconhecem os efeitos negativos que o cyberbullying tem sobre a imagem das pessoas em ambientes digitais. Compreender o lugar que as emoções ocupam nas agressões mediadas pelas TIC é essencial para gerar conhecimento que serve de base para o desenho e implementação de programas de intervenção psicossocial do cyberbullying e promover espaços de reflexão sobre o que significa intimidade, amizade e confie na era digital. ABSTRACT. Cyberbullying is a growing problem, especially among the adolescent population. This phenomenon warrants scientific research that aims to explain it in as many aspects as possible, including emotions. In this context, this research deals with the analysis of anger in adolescents involved in cyberbullying situations. A study with qualitative design and the phenomenological-hermeneutic method was conducted, in which 31 adolescents between the ages of 12 and 17 were interviewed, involved in cyberbullying situations in the roles of victims or bystanders. Victims of cyberbullying feel angry, especially when the assaults come from people they considered their friends. This emotion is experienced along with other affections such as sadness and shame. For bystanders, anger is associated with situations of injustice and the perception that aggressors have no empathy for the victims. Adolescents recognize the negative effects that cyberbullying has on people's image in digital environments. Understanding the place of emotions in ICT-mediated aggressions is essential to generate knowledge that serves as the basis for the design and implementation of psychosocial intervention programs in cyberbullying, and to promote spaces for reflection on what intimacy, friendship, and trust mean in the digital age.

Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract characterised by multi-factorial aetiology. In IBS physiopathology are involved diverse factors between them biological, psychosocial, and environmental components which affect the immune activation status of gut mucosa. Among these factors is recognized the intestinal parasitosis. Post-infection IBS (PI-IBS) is recognised as a subgroup of functional disorders whose symptoms onset appear after a symptomatic intestinal infection caused by microbial agents. There are few studies regarding of relationship between IBS and intestinal parasitosis in Chile. However, is has been well described a positive association between IBS and Blastocystis hominis infections, one of prevalent parasites in Chile. In other countries, is also described a relationship between IBS and amebiasis and giardiasis. Both, characterized by a common mode of transmission through water as well as contaminated food. Because the high prevalence of parasitosis in our country it is necessary to expand the association studies to clarify the strength of the parasites ethiology in IBS.

Introducción: La relación causa efecto entre la hipertensión arterial sistémica y un mayor riesgo para desarrollar síndrome de apnea-hipopnea obstructiva del sueño (SAHOS) es aún incierta. El desconocimiento de la influencia del SAHOS sobre lahipertensión arterial ha llevado al excesivo diagnóstico de hipertensión arterial idiopática, desmotivando la búsqueda de la real causa subyacente, que en la mayoría de los casos puede deberse a trastornos del sueño. Materiales y métodos: En el presente estudio se incluyen pacientes hipertensos quienesconsultaron en el centro médico ONIRIS, especializado en sueño, y se evaluó en ellos variables como índice de masa corporal, índice cintura cadera, circunferencia del cuello, tabaquismo y alcohol, para determinar cuáles de ellos desarrollaron SAHOS.Resultados: De 309 pacientes estudiados, el 67,4%, fue positivo para SAHOS, confirmando algún grado de asociación entre ésta y la hipertensión arterial. Además, variables incluidas como factores de riesgo arrojaron resultados muy similares a losobtenidos en otros estudios que han demostrado dicha asociación. Conclusiones: Tiene predominio por el sexo masculino, se presenta generalmente en mayores de 50 años y obesos; dichos factores ponen en un riesgo elevado al pacientede desarrollar eventos vasculares que disminuyen la calidad de vida e incluso llevarlo a la muerte.

Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract characterised by multi-factorial aetiology. In IBS physiopathology are involved diverse factors between them biological, psychosocial, and environmental components which affect the immune activation status of gut mucosa. Among these factors is recognized the intestinal parasitosis. Post-infection IBS (PI-IBS) is recognised as a subgroup of functional disorders whose symptoms onset appear after a symptomatic intestinal infection caused by microbial agents. There are few studies regarding of relationship between IBS and intestinal parasitosis in Chile. However, is has been well described a positive association between IBS and Blastocystis hominis infections, one of prevalent parasites in Chile. In other countries, is also described a relationship between IBS and amebiasis and giardiasis. Both, characterized by a common mode of transmission through water as well as contaminated food. Because the high prevalence of parasitosis in our country it is necessary to expand the association studies to clarify the strength of the parasites ethiology in IBS.