7 results on '"Valentina, Genovese"'
Search Results
2. Clinical feasibility of longitudinal lateral ventricular volume measurements on T2-FLAIR across MRI scanner changes
- Author
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Dejan Jakimovski, Robert Zivadinov, Niels Bergsland, Deepa P. Ramasamy, Jesper Hagemeier, Antonia Valentina Genovese, David Hojnacki, Bianca Weinstock-Guttman, and Michael G. Dwyer
- Subjects
Multiple sclerosis ,MRI ,Whole brain atrophy ,Lateral ventricular volume ,Disability progression ,MRI field strength ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Greater brain atrophy is associated with disability progression (DP) in patients with multiple sclerosis (PwMS). However, methodological challenges limit its routine clinical use. Objective: To determine the feasibility of atrophy measures as markers of DP in PwMS scanned across different MRI field strengths. Methods: A total of 980 PwMS were scanned on either 1.5 T or 3.0 T MRI scanners. Demographic and clinical data were retrospectively collected, and the presence of DP was determined according to standard clinical trial criteria. Lateral ventricular volume (LVV) change was measured with the NeuroSTREAM technique on clinical routine T2-FLAIR images. Percent brain volume change (PBVC) was measured using SIENA and ventricular cerebrospinal fluid (vCSF) % change was measured using VIENA and SIENAX algorithms on 3D T1-weighted images (WI). Stable vs. DP PwMS were compared using analysis of covariance (ANCOVA). Mixed modeling determined the effect of MRI scanner change on MRI-derived atrophy measures. Results: Longitudinal LVV analysis was successful in all PwMS. SIENA-based PBVC and VIENA-based changes failed in 37.6% of cases, while SIENAX-based vCSF failed in 12.9% of cases. PwMS with DP (n = 241) had significantly greater absolute (20.9% vs. 8.7%, d = 0.66, p
- Published
- 2021
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3. Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis
- Author
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Deepa P. Ramasamy, Antonia Valentina Genovese, Bianca Weinstock-Guttman, Dejan Jakimovski, Niels Bergsland, Alexis A Lizarraga, David Hojnacki, Robert Zivadinov, Michael G. Dwyer, Channa Kolb, and Jesper Hagemeier
- Subjects
medicine.medical_specialty ,Clinically isolated syndrome ,Proportional hazards model ,business.industry ,Multiple sclerosis ,Hazard ratio ,Urology ,Retrospective cohort study ,medicine.disease ,Confidence interval ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Cerebrospinal fluid ,030220 oncology & carcinogenesis ,medicine ,Radiology, Nuclear Medicine and imaging ,business - Abstract
Background Atrophied T2 lesion volume at MRI is an imaging measure that reflects the replacement of T2 lesions by cerebrospinal fluid spaces in patients with multiple sclerosis (MS). Purpose To investigate the association of atrophied T2 lesion volume and development of disability progression (DP) and conversion to secondary progressive MS (SPMS). Materials and Methods This retrospective study included 1612 participants recruited from 2006 to 2016 and followed up for 5 years with clinical and MRI examinations. Accumulation of T2 lesion volume, atrophied T2 lesion volume, percentage brain volume change (PBVC), and percentage ventricular volume change (PVVC) were measured. Disability progression and secondary progressive conversion were defined by using standardized guidelines. Analysis of covariance (ANCOVA) adjusted for age and Cox regression adjusted for age and sex were used to compare study groups and explore associations between MRI and clinical outcomes. Results A total of 1314 patients with MS (1006 women; mean age, 46 years ± 11 [standard deviation]) and 124 patients with clinically isolated syndrome (100 women; mean age, 39 years ± 11) along with 147 healthy control subjects (97 women; mean age, 42 years ± 13) were evaluated. A total of 336 of 1314 (23%) patients developed DP, and in 67 of 1213 (5.5%) the disease converted from clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS) to SPMS. Patients with conversion to DP had higher atrophied T2 lesion volume (+34.4 mm3; 95% confidence interval [CI]: 17.2 mm3, 51.5 mm3; d = 0.27; P < .001) and PBVC (-0.21%; 95% CI: -0.36%, -0.05%; d = 0.19; P = .042) but not PVVC (0.36%; 95% CI: -0.93%, 1.65%; d = 0.04; P = .89) or T2 lesion volume change (-64.5 mm3; 95% CI: -315.2 mm3, 186.3 mm3; d = 0.03; P = .67) when compared with DP nonconverters. ANCOVA showed that atrophied T2 lesion volume was associated with conversion from CIS or RRMS to SPMS (+26.4 mm3; 95% CI: 4.2 mm3, 56.9 mm3; d = 0.23; P = .002) but not PBVC (-0.14%; 95% CI: -0.46%, 0.18%; d = 0.11; P = .66), PVVC (+0.18%; 95% CI: -2.49%, 2.72%; d = 0.01; P = .75), or T2 lesion volume change (-46.4 mm3; 95% CI: -460.8 mm3, 367.9 mm3; d = 0.03; P = .93). At Cox regression analysis, only atrophied T2 lesion volume was associated with the DP (hazard ratio, 1.23; P < .001) and conversion to SPMS (hazard ratio, 1.16; P = .008). Conclusion Atrophied brain T2 lesion volume is a robust MRI marker of MS disability progression and conversion into a secondary progressive disease course. © RSNA, 2019 Online supplemental material is available for this article. See also the editorial by Chiang in this issue.
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- 2019
4. Neuroimaging Features of COVID-19: Retrospective Northern Italy Multicenter Study and a Scoping Review of the Prevalence of COVID-19 Associated Acute Cerebrovascular Diseases
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Andrea Giorgianni, Sergio Balbi, Valentina Genovese, Luca Valvassori, Letterio S. Politi, Francesca Bandiera, Lisa Nicolì, Anna Mercuri, Enrico Colli-Tibaldi, Carlo Sozzi, Gabriele Vinacci, Casale Silvia, Andrea De Vito, Edoardo Agosti, Alberto Terrana, Nunzio Paolo Nuzzi, E. Bianchini, Fabio Baruzzi, Mirko Trentadue, Laura Longhi, Fabio Triulzi, Pietro Bernasconi, Alessandra Polistena, Francesco D'Amore, Francesco Asteggiano, and Elvis Lafe
- Subjects
Pediatrics ,medicine.medical_specialty ,Multicenter study ,Coronavirus disease 2019 (COVID-19) ,Neuroimaging ,business.industry ,Medicine ,business ,Northern italy - Abstract
Background The primary aim of this study was to provide additional data of neuroimaging features of coronavirus disease 2019 (COVID-19) in a large-scale population admitted in several northern Italy institutions. The secondary aim was to analyze acute cerebrovascular disease (CVD) prevalence in COVID-19. Methods A database of confirmed COVID-19 hospitalized patients who developed acute neurological symptoms and underwent any neuroimaging was retrospectively gathered from twelve institutions based in Lombardy from February 21st to July 10th. To assess the prevalence of CVD we conducted a scoping review following the PRISMA extension guidelines for scoping reviews. We searched PubMed/Medline, SCOPUS and EMBASE databases for peer-reviewed in-press or published studies from December to January 2021 reporting CVD in COVID-19 patients. Results Out of 90 COVID-19 patients who were referred to neuroimaging, 78 (87%) showed CVD, in particular 65 had acute ischemic strokes (AIS), 8 had intracerebral hemorrhages, 2 subarachnoid hemorrhages (SAH) and 3 showed clinical and imaging findings in keeping with posterior reversible encephalopathy syndrome (PRES); 6 patients (7%) showed clinical and imaging findings highly suggestive of encephalitis; 3 patients (3%) showed demyelinating diseases: 1 case of MS progression, 1 case of newly diagnosed MS and 1 case of acute disseminated encephalomyelitis (ADEM); 2 cases (2%) acuity of chronic subdural hematoma (cSDH); 1 patient (1%) with Guillain Barré syndrome. In addiction two patients with CVD developed cauda polyradiculitis and tetraparesis. In our scoping review out of 3275 studies, 24 satisfied the inclusion criteria: in a pooled total population of 136198 patients, the pooled prevalence of CVD was 0.9%. In particular 0.8% of AIS and 0.1% of ICH and 0.003% of PRES. Conclusions Our study shows a high prevalence of CVD among patients who developed acute neurological symptoms, which is in line with papers reporting data comparable to ours. The heterogeneity of clinical reports, however, constitutes a limitation when comparing our findings with those of the clinical papers. Nonetheless, CVD could be a frightening association with COVID-19, particularly in critically ill patients. Healthcare policymakers and clinicians should be prepared to a likely increase in workload and to rearrange the strategy of healthcare delivery.
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- 2021
5. Vascular aspects of multiple sclerosis: emphasis on perfusion and cardiovascular comorbidities
- Author
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Bianca Weinstock-Guttman, Robert Zivadinov, Dejan Jakimovski, Matthew Topolski, and Antonia Valentina Genovese
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medicine.medical_specialty ,Multiple Sclerosis ,business.industry ,General Neuroscience ,Multiple sclerosis ,Central nervous system ,Disease ,Comorbidity ,medicine.disease ,030227 psychiatry ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Cardiovascular Diseases ,Internal medicine ,medicine ,Cardiology ,Humans ,Pharmacology (medical) ,Neurology (clinical) ,business ,Perfusion ,030217 neurology & neurosurgery - Abstract
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system. Over the last two decades, more favorable MS long-term outcomes have contributed toward increase in prevalence of the aged MS population. Emergence of age-associated pathology, such as cardiovascular diseases, may interact with the MS pathophysiology and further contribute to disease progression. Areas covered: This review summarizes the cardiovascular involvement in MS pathology, its disease activity, and progression. The cardiovascular health, the presence of various cardiovascular diseases, and their effect on MS cognitive performance are further explored. In similar fashion, the emerging evidence of a higher incidence of extracranial arterial pathology and its association with brain MS pathology are discussed. Finally, the authors outline the methodologies behind specific perfusion magnetic resonance imaging (MRI) and ultrasound Doppler techniques, which allow measurement of disease-specific and age-specific vascular changes in the aging population and MS patients. Expert opinion: Cardiovascular pathology significantly contributes to worse clinical and MRI-derived disease outcomes in MS. Global and regional cerebral hypoperfusion may be associated with poorer physical and cognitive performance. Prevention, improved detection, and treatment of the cardiovascular-based pathology may improve the overall long-term health of MS patients.
- Published
- 2019
6. Clinical feasibility of longitudinal lateral ventricular volume measurements on T2-FLAIR across MRI scanner changes
- Author
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David Hojnacki, Jesper Hagemeier, Deepa P. Ramasamy, Michael G. Dwyer, Niels Bergsland, Bianca Weinstock-Guttman, Dejan Jakimovski, Robert Zivadinov, and Antonia Valentina Genovese
- Subjects
PMS, progressive MS ,Fluid-attenuated inversion recovery ,CSF, cerebrospinal fluid ,lcsh:RC346-429 ,vCSF, ventricular cerebrospinal fluid ,0302 clinical medicine ,Medicine ,Disability progression ,AN(C)OVA, analysis of (co)variance ,Lateral ventricular volume ,05 social sciences ,Brain ,Regular Article ,DP, disability progression ,SNR, signal-to-noise ratio ,Clinical routine ,Magnetic Resonance Imaging ,Whole brain atrophy ,Neurology ,PPMS, primary-progressive MS ,Brain size ,Disease Progression ,DMT, disease modifying treatment ,lcsh:R858-859.7 ,LVV, lateral ventricular volume ,MRI ,CNR, contrast-to-noise ratio ,Scanner ,RRMS, relapsing-remitting MS ,Cognitive Neuroscience ,PwMS, patients with MS ,PBVC, percent brain volume change ,lcsh:Computer applications to medicine. Medical informatics ,050105 experimental psychology ,MS, multiple sclerosis ,EDSS, Expanded Disability Status Scale ,SPMS, secondary-progressive MS ,Multiple sclerosis ,PLVVC, percent lateral ventricular volume change ,03 medical and health sciences ,Atrophy ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,IQR, interquartile range ,lcsh:Neurology. Diseases of the nervous system ,Retrospective Studies ,SE, standard error ,business.industry ,SIENA, Structural Image Evaluation using Normalisation of Atrophy ,WBV, whole brain volume ,medicine.disease ,FLAIR, fluid-attenuated inversion recovery ,CI, confidence intervals ,MRI field strength ,Feasibility Studies ,Ventricular volume ,sense organs ,Neurology (clinical) ,business ,Nuclear medicine ,030217 neurology & neurosurgery - Abstract
Highlights • Central and whole brain atrophy are faster in MS patients with disability progression. • These measures can be reliably assessed on clinically-available FLAIR images. • They are meaningful even with longitudinal scanner and field strength changes., Background Greater brain atrophy is associated with disability progression (DP) in patients with multiple sclerosis (PwMS). However, methodological challenges limit its routine clinical use. Objective To determine the feasibility of atrophy measures as markers of DP in PwMS scanned across different MRI field strengths. Methods A total of 980 PwMS were scanned on either 1.5 T or 3.0 T MRI scanners. Demographic and clinical data were retrospectively collected, and the presence of DP was determined according to standard clinical trial criteria. Lateral ventricular volume (LVV) change was measured with the NeuroSTREAM technique on clinical routine T2-FLAIR images. Percent brain volume change (PBVC) was measured using SIENA and ventricular cerebrospinal fluid (vCSF) % change was measured using VIENA and SIENAX algorithms on 3D T1-weighted images (WI). Stable vs. DP PwMS were compared using analysis of covariance (ANCOVA). Mixed modeling determined the effect of MRI scanner change on MRI-derived atrophy measures. Results Longitudinal LVV analysis was successful in all PwMS. SIENA-based PBVC and VIENA-based changes failed in 37.6% of cases, while SIENAX-based vCSF failed in 12.9% of cases. PwMS with DP (n = 241) had significantly greater absolute (20.9% vs. 8.7%, d = 0.66, p
- Published
- 2021
7. Between political opportunities and strategic dilemmas: The choice of ’Double Track’ by the activists of an Occupied Social Centre in Italy
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Gianni Piazza and Valentina Genovese
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Cultural Studies ,Political opportunity ,Mobilization ,Eviction ,Sociology and Political Science ,occupied social centres, political opportunity structure, strategic dilemmas. protest campaign. Italy ,05 social sciences ,0507 social and economic geography ,occupied social centres ,political opportunity structure ,Public administration ,Track (rail transport) ,0506 political science ,Politics ,Political system ,Order (exchange) ,strategic dilemmas. protest campaign. Italy ,Law ,Local government ,050602 political science & public administration ,Sociology ,050703 geography - Abstract
According to the political opportunity structure (POS) framework, mobilization tends to intensify when channels of access to the authorities open, leading the protest actors to hope for success. This happened during the protest campaign aimed at the reopening of the occupied Social Centre ‘Experia’ in Catania (Italy), after the eviction by police, because unexpectedly moderate centre-left political actors supported mobilization and the centre-right local government accepted to put the issue on the institutional agenda; nevertheless the social centre was not reopened. In order to explain why the mobilization was unsuccessful, we analysed the protest campaign combining the POS framework with the approach to strategic dilemmas by James Jasper; if opportunities and restraints of the political system influence the choices and behaviours of unconventional actors, in their turn the actions and decisions made by movement activists affect the POS. In this case, the social centre activists filtered the cons...
- Published
- 2016
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