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13 results on '"Valencia, Edward"'

1. Toward Improving Early Diagnosis of Congenital Chagas Disease in an Endemic Setting

Author

Working Group on Chagas Disease in Bolivia and Peru, Messenger, Louisa A., Gilman, Robert H., Verastegui, Manuela, Cardenas, Gerson Galdos, Sanchez, Gerardo, Valencia, Edward, Sanchez, Leny, Malaga, Edith, Rendell, Victoria R., Jois, Malasa, Shah, Vishal, Santos, Nicole, del Carmen Abastoflor, Maria, LaFuente, Carlos, Colanzi, Rony, Bozo, Ricardo, and Bern, Caryn

Published
2017

2. Sustained Domestic Vector Exposure Is Associated With Increased Chagas Cardiomyopathy Risk but Decreased Parasitemia and Congenital Transmission Risk Among Young Women in Bolivia

Author

Working Group on Chagas Disease in Bolivia and Peru, Kaplinski, Michelle, Jois, Malasa, Galdos-Cardenas, Gerson, Rendell, Victoria R., Shah, Vishal, Do, Rose Q., Marcus, Rachel, Pena, Melissa S. Burroughs, del Carmen Abastoflor, Maria, LaFuente, Carlos, Bozo, Ricardo, Valencia, Edward, Verastegui, Manuela, Colanzi, Rony, Gilman, Robert H., and Bern, Caryn

Published
2015

5. HIV and Chagas Disease: An Evaluation of the Use of Real-Time Quantitative Polymerase Chain Reaction to Measure Levels of Trypanosoma cruzi Parasitemia in HIV Patients in Cochabamba, Bolivia

Author

Reimer-McAtee, Melissa J., primary, Mejia, Carolina, additional, Clark, Taryn, additional, Terle, Jules, additional, Pajuelo, Monica J., additional, Cabeza, Jeanne, additional, Lora, Meredith H., additional, Valencia, Edward, additional, Castro, Rosario, additional, Lozano, Daniel, additional, Bern, Caryn, additional, Torrico, Faustino, additional, and Gilman, Robert H., additional

Published
2021
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6. Sustained Domestic Vector Exposure Is Associated With Increased Chagas Cardiomyopathy Risk but Decreased Parasitemia and Congenital Transmission Risk Among Young Women in Bolivia

Author

Kaplinski, Michelle, Jois, Malasa, Galdos-Cardenas, Gerson, Rendell, Victoria R., Shah, Vishal, Do, Rose Q., Marcus, Rachel, Burroughs Pena, Melissa S., del Carmen Abastoflor, Maria, LaFuente, Carlos, Bozo, Ricardo, Valencia, Edward, Verastegui, Manuela, Colanzi, Rony, Gilman, Robert H., Bern, Caryn, Sanchez, Leny, Ferrufino, Lisbeth, Malaga, Edith, Quispe, Sara, Hinojosa, Edith, Ramirez, Margot, Saenza, Eliana, Flores-Franco, Jorge Luis, Acosta, Janet, Sanchez, Gerardo, Suxo, Maribel, Roncales, Hilsen, Ramirez, Fernando, Escalera, Nazaret Bozo, Espinoza, Celia, and Vizcarra, Janet

Subjects
parasitic diseases
Abstract

Vector exposure showed a direct association with Chagas cardiomyopathy, but an inverse relationship with maternal parasitemia and congenital transmission. We hypothesize that repeated antigen exposure maintains an inflammatory response, increasing cardiomyopathy, but this upregulation improves control of parasitemia during pregnancy

Published
2017

7. Virus-like Particle Display of the α-Gal Carbohydrate for Vaccination against Leishmania Infection

Author

Moura, Anna Paula V., primary, Santos, Luiza C. B., additional, Brito, Carlos Ramon Nascimento, additional, Valencia, Edward, additional, Junqueira, Caroline, additional, Filho, Adalberto A. P., additional, Sant’Anna, Mauricio R. V., additional, Gontijo, Nelder F., additional, Bartholomeu, Daniella C., additional, Fujiwara, Ricardo T., additional, Gazzinelli, Ricardo T., additional, McKay, Craig S., additional, Sanhueza, Carlos A., additional, Finn, M. G., additional, and Marques, Alexandre Ferreira, additional

Published
2017
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8. Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients

Author

Ramírez, Juan Carlos, primary, Cura, Carolina Inés, additional, da Cruz Moreira, Otacilio, additional, Lages-Silva, Eliane, additional, Juiz, Natalia, additional, Velázquez, Elsa, additional, Ramírez, Juan David, additional, Alberti, Anahí, additional, Pavia, Paula, additional, Flores-Chávez, María Delmans, additional, Muñoz-Calderón, Arturo, additional, Pérez-Morales, Deyanira, additional, Santalla, José, additional, Marcos da Matta Guedes, Paulo, additional, Peneau, Julie, additional, Marcet, Paula, additional, Padilla, Carlos, additional, Cruz-Robles, David, additional, Valencia, Edward, additional, Crisante, Gladys Elena, additional, Greif, Gonzalo, additional, Zulantay, Inés, additional, Costales, Jaime Alfredo, additional, Alvarez-Martínez, Miriam, additional, Martínez, Norma Edith, additional, Villarroel, Rodrigo, additional, Villarroel, Sandro, additional, Sánchez, Zunilda, additional, Bisio, Margarita, additional, Parrado, Rudy, additional, Maria da Cunha Galvão, Lúcia, additional, Jácome da Câmara, Antonia Cláudia, additional, Espinoza, Bertha, additional, Alarcón de Noya, Belkisyole, additional, Puerta, Concepción, additional, Riarte, Adelina, additional, Diosque, Patricio, additional, Sosa-Estani, Sergio, additional, Guhl, Felipe, additional, Ribeiro, Isabela, additional, Aznar, Christine, additional, Britto, Constança, additional, Yadón, Zaida Estela, additional, and Schijman, Alejandro G., additional

Published
2015
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9. Sustained Domestic Vector Exposure Is Associated With Increased Chagas Cardiomyopathy Risk but Decreased Parasitemia and Congenital Transmission Risk Among Young Women in Bolivia

Author

Kaplinski, Michelle, primary, Jois, Malasa, additional, Galdos-Cardenas, Gerson, additional, Rendell, Victoria R., additional, Shah, Vishal, additional, Do, Rose Q., additional, Marcus, Rachel, additional, Burroughs Pena, Melissa S., additional, del Carmen Abastoflor, Maria, additional, LaFuente, Carlos, additional, Bozo, Ricardo, additional, Valencia, Edward, additional, Verastegui, Manuela, additional, Colanzi, Rony, additional, Gilman, Robert H., additional, and Bern, Caryn, additional

Published
2015
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10. Trypanosoma cruzi-Infected Pregnant Women without Vector Exposure Have Higher Parasitemia Levels: Implications for Congenital Transmission Risk

Author

Rendell, Victoria R., primary, Gilman, Robert H., additional, Valencia, Edward, additional, Galdos-Cardenas, Gerson, additional, Verastegui, Manuela, additional, Sanchez, Leny, additional, Acosta, Janet, additional, Sanchez, Gerardo, additional, Ferrufino, Lisbeth, additional, LaFuente, Carlos, additional, Abastoflor, Maria del Carmen, additional, Colanzi, Rony, additional, and Bern, Caryn, additional

Published
2015
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11. Toward Improving Early Diagnosis of Congenital Chagas Disease in an Endemic Setting.

Author

Messenger, Louisa A., Gilman, Robert H., Verastegui, Manuela, Galdos-Cardenas, Gerson, Sanchez, Gerardo, Valencia, Edward, Sanchez, Leny, Malaga, Edith, Rendell, Victoria R., Jois, Malasa, Shah, Vishal, Santos, Nicole, del Carmen Abastoflor, Maria, LaFuente, Carlos, Colanzi, Rony, Bozo, Ricardo, and Bern, Caryn

Subjects
CHAGAS' disease, EARLY diagnosis, RAPID methods (Microbiology), IMMUNOGLOBULIN M, URBAN hospitals
Abstract

Background. Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy is highly efficacious and well tolerated, but current assays for early detection fail to detect >50% of infected neonates, and 9-month follow-up is low. Methods. Women who presented for delivery at 2 urban hospitals in Santa Cruz Department, Bolivia, were screened by rapid test. Specimens from infants of infected women were tested by microscopy (micromethod), quantitative PCR (qPCR), and immunoglobulin (Ig)M trypomastigote excreted-secreted antigen (TESA)-blots at birth and 1 month and by IgG serology at 6 and 9 months. Results. Among 487 infants of 476 seropositive women, congenital T. cruzi infection was detected in 38 infants of 35 mothers (7.8%). In cord blood, qPCR, TESA-blot, and micromethod sensitivities/specificities were 68.6%/99.1%, 58.3%/99.1%, and 16.7%/100%, respectively. When birth and 1-month results were combined, cumulative sensitivities reached 84.2%, 73.7%, and 34.2%, respectively. Low birthweight and/or respiratory distress were reported in 11 (29%) infected infants. Infants with clinical signs had higher parasite loads and were significantly more likely to be detected by micromethod. Conclusions. The proportion of T. cruzi-infected infants with clinical signs has fallen since the 1990s, but symptomatic congenital Chagas disease still represents a significant, albeit challenging to detect, public health problem. Molecular methods could facilitate earlier diagnosis and circumvent loss to follow-up but remain logistically and economically prohibitive for routine screening in resource-limited settings. [ABSTRACT FROM AUTHOR]

Published
2017
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12. Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruziDNA in Blood Samples from Chagas Disease Patients

Author

Ramírez, Juan Carlos, Cura, Carolina Inés, da Cruz Moreira, Otacilio, Lages-Silva, Eliane, Juiz, Natalia, Velázquez, Elsa, Ramírez, Juan David, Alberti, Anahí, Pavia, Paula, Flores-Chávez, María Delmans, Muñoz-Calderón, Arturo, Pérez-Morales, Deyanira, Santalla, José, Marcos da Matta Guedes, Paulo, Peneau, Julie, Marcet, Paula, Padilla, Carlos, Cruz-Robles, David, Valencia, Edward, Crisante, Gladys Elena, Greif, Gonzalo, Zulantay, Inés, Costales, Jaime Alfredo, Alvarez-Martínez, Miriam, Martínez, Norma Edith, Villarroel, Rodrigo, Villarroel, Sandro, Sánchez, Zunilda, Bisio, Margarita, Parrado, Rudy, Maria da Cunha Galvão, Lúcia, Jácome da Câmara, Antonia Cláudia, Espinoza, Bertha, Alarcón de Noya, Belkisyole, Puerta, Concepción, Riarte, Adelina, Diosque, Patricio, Sosa-Estani, Sergio, Guhl, Felipe, Ribeiro, Isabela, Aznar, Christine, Britto, Constança, Yadón, Zaida Estela, and Schijman, Alejandro G.

Abstract

An international study was performed by 26 experienced PCR laboratories from 14 countries to assess the performance of duplex quantitative real-time PCR (qPCR) strategies on the basis of TaqMan probes for detection and quantification of parasitic loads in peripheral blood samples from Chagas disease patients. Two methods were studied: Satellite DNA (SatDNA) qPCR and kinetoplastid DNA (kDNA) qPCR. Both methods included an internal amplification control. Reportable range, analytical sensitivity, limits of detection and quantification, and precision were estimated according to international guidelines. In addition, inclusivity and exclusivity were estimated with DNA from stocks representing the different Trypanosoma cruzidiscrete typing units and Trypanosoma rangeliand Leishmaniaspp. Both methods were challenged against 156 blood samples provided by the participant laboratories, including samples from acute and chronic patients with varied clinical findings, infected by oral route or vectorial transmission. kDNA qPCR showed better analytical sensitivity than SatDNA qPCR with limits of detection of 0.23 and 0.70 parasite equivalents/mL, respectively. Analyses of clinical samples revealed a high concordance in terms of sensitivity and parasitic loads determined by both SatDNA and kDNA qPCRs. This effort is a major step toward international validation of qPCR methods for the quantification of T. cruziDNA in human blood samples, aiming to provide an accurate surrogate biomarker for diagnosis and treatment monitoring for patients with Chagas disease.

Published
2015
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