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6. A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

Author

Lopes, Mateus S., primary, Baptistella, Gabriel B., additional, Nunes, Giovana G., additional, Ferreira, Matheus V., additional, Cunha, Joice Maria, additional, Oliveira, Kauê Marcel de, additional, Acco, Alexandra, additional, Lopes, Maria Luiza C., additional, Couto Alves, Alexessander, additional, Valdameri, Glaucio, additional, Moure, Vivian R., additional, Picheth, Geraldo, additional, Manica, Graciele C. M., additional, and Rego, Fabiane G. M., additional

Published
2024
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8. Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

Author

Kita, Diogo Henrique, Guragossian, Nathalie, Zattoni, Ingrid Fatima, Moure, Vivian Rotuno, Rego, Fabiane Gomes de Moraes, Lusvarghi, Sabrina, Moulenat, Thomas, Belhani, Billel, Picheth, Geraldo, Bouacida, Sofiane, Bouaziz, Zouhair, Marminon, Christelle, Berredjem, Malika, Jose, Joachim, Gonçalves, Marcos Brown, Ambudkar, Suresh V., Valdameri, Glaucio, and Le Borgne, Marc

Published
2021
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11. Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery

Author

Valdameri, Glaucio, primary, Kita, Diogo Henrique, additional, Dutra, Julia de Paula, additional, Gomes, Diego Lima, additional, Tonduru, Arun Kumar, additional, Kronenberger, Thales, additional, Gavinho, Bruno, additional, Rossi, Izadora Volpato, additional, Carvalho, Mariana Mazetto de, additional, Pérès, Basile, additional, Zattoni, Ingrid Fatima, additional, Rego, Fabiane Gomes de Moraes, additional, Picheth, Geraldo, additional, Freitas, Rilton Alves de, additional, Poso, Antti, additional, Ambudkar, Suresh V., additional, Ramirez, Marcel I., additional, Boumendjel, Ahcène, additional, and Moure, Vivian Rotuno, additional

Published
2023
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14. Supplementary Figure 6 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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15. Data from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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16. Supplementary Figure 3 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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17. Supplementary Figure 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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18. Supplementary Figure 5 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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19. Supplementary Video 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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20. Supplementary Tables 1-9, Movie Legend, Methods from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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21. Supplementary Figure 4 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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22. Supplementary Figure 2 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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23. An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Author

Zanzarini, Isadora da Silva, primary, Barbosa, Gustavo, primary, Prado, Larissa de Oliveira, primary, Zattoni, Ingrid Fatima, primary, Da Paz, Gustavo, primary, Prado, Ademir Luiz do, primary, Volanski, Waldemar, primary, Lavarda, Marcos Dinís, primary, Rego, Fabiane Gomes de Moraes, primary, Picheth, Geraldo, primary, Moure, Vivian Rotuno, primary, and Valdameri, Glaucio, primary

Published
2023
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24. Modulation of defence and iron homeostasis genes in rice roots by the diazotrophic endophyte Herbaspirillum seropedicae

Author

Brusamarello-Santos, Liziane Cristina Campos, Alberton, Dayane, Valdameri, Glaucio, Camilios-Neto, Doumit, Covre, Rafael, Lopes, Katia de Paiva, Zibetti Tadra-Sfeir, Michelle, Faoro, Helisson, Adele Monteiro, Rose, Barbosa-Silva, Adriano, John Broughton, William, Oliveira Pedrosa, Fabio, Wassem, Roseli, and Souza, Emanuel Maltempi de

Published
2019
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27. STRUCTURAL AND MOLECULAR CHARACTERIZATION OF LOPINAVIR AND IVERMECTIN AS BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) INHIBITORS.

Author

de Paula Dutra, Julia, Scheiffer, Gustavo, Kronenberger, Thales, Cruz Gomes, Lucas Julian, Zanzarini, Isadora, dos Santos, Kelly Karoline, Tonduru, Arun K., Poso, Antti, de Moraes Rego, Fabiane Gomes, Picheth, Geraldo, Valdameri, Glaucio, and Moure, Vivian Rotuno

Subjects
BREAST cancer, ATP-binding cassette transporters, IVERMECTIN, ANTIPARASITIC agents, MOLECULAR dynamics, MOLECULAR docking
Abstract

A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors is a promising approach to overcome the resistance in cancer. This study aimed to characterize the molecular mechanism of ABCG2 inhibitors identified by a repurposing drug strategy using antiviral, anti-inflammatory and antiparasitic agents. Lopinavir and ivermectin can be considered as pan-inhibitors of ABC transporters, since both compounds inhibited ABCG2, P-glycoprotein and MRP1. They inhibited ABCG2 activity showing IC50 values of 25.5 and 23.4 µM, respectively. These drugs were highly cytotoxic and not transported by ABCG2. Additionally, these drugs increased the 5D3 antibody binding and did not affect the mRNA and protein expression levels. Cell-based analysis of the type of inhibition suggested a non-competitive inhibition, which was further corroborated by in silico approaches of molecular docking and molecular dynamics simulations. These results showed an overlap of the lopinavir and ivermectin binding sites on ABCG2, mainly interacting with E446 residue. However, the substrate mitoxantrone occupies a different site, binding to the F436 region, closer to the L554/L555 plug. In conclusion, these results revealed the mechanistic basis of lopinavir and ivermectin interaction with ABCG2. [ABSTRACT FROM AUTHOR]

Published
2023
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28. A new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP/ABCG2)

Author

Zattoni, Ingrid Fatima, primary, Kronenberger, Thales, additional, Kita, Diogo Henrique, additional, Guanaes, Lais Danciguer, additional, Guimarães, Matheus Murmel, additional, de Oliveira Prado, Larissa, additional, Ziasch, Melanie, additional, Vesga, Luis C., additional, Gomes de Moraes Rego, Fabiane, additional, Picheth, Geraldo, additional, Gonçalves, Marcos Brown, additional, Noseda, Miguel D., additional, Ducatti, Diogo R.B., additional, Poso, Antti, additional, Robey, Robert W., additional, Ambudkar, Suresh V., additional, Moure, Vivian Rotuno, additional, Gonçalves, Alan Guilherme, additional, and Valdameri, Glaucio, additional

Published
2022
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29. Identification of polyoxovanadates as new P-glycoprotein inhibitors: insights into the mechanism of inhibition

Author

Kita, Diogo Henrique, de Andrade, Gisele Alves, Missina, Juliana Morais, Postal, Kahoana, Boell, Viktor Kalbermatter, Santana, Francielli Sousa, Zattoni, Ingrid Fatima, da Silva Zanzarini, Isadora, Moure, Vivian Rotuno, de Moraes Rego, Fabiane Gomes, Picheth, Geraldo, de Souza, Emanuel Maltempi, Mitchell, David A., Ambudkar, Suresh V., Nunes, Giovana Gioppo, and Valdameri, Glaucio

Subjects
ATP Binding Cassette Transporter, Subfamily B, Member 1, Article
Abstract

A promising strategy to overcome multidrug resistance is the use of inhibitors of ABC drug transporters. For this reason, we evaluated the polyoxovanadates (POVs) ([V(10)O(28)](6−) (V(10)), [H(6)V(14)O(38)(PO(4))](5−) (V(14)), [V(15)O(36)Cl](6−) (V(15)) and [V(18)O(42)I](7−) (V(18)) as inhibitors of three major multidrug resistance-linked ABC transporters: P-glycoprotein (P-gp), ABCG2 and MRP1. All of the POVs selectively inhibited P-gp. V(10) and V(18) were the two most promising compounds, with IC(50) values of transport inhibition of 25.4 and 22.7 μM, respectively. Both compounds inhibited P-gp ATPase activity, with the same IC(50) value of 1.26 μM. V(10) and V(18) triggered different conformational changes in the P-gp protein with time-dependent inhibition, which was confirmed using the synthesized salt of V(10) with rhodamine B, RhoB-V(10).

Published
2021

30. Polyoxovanadates as new P‐glycoprotein inhibitors: insights into the mechanism of inhibition

Author

Kita, Diogo Henrique, primary, Andrade, Gisele Alves, additional, Missina, Juliana Morais, additional, Postal, Kahoana, additional, Boell, Viktor Kalbermatter, additional, Santana, Francielli Sousa, additional, Zattoni, Ingrid Fatima, additional, Zanzarini, Isadora da Silva, additional, Moure, Vivian Rotuno, additional, Rego, Fabiane Gomes de Moraes, additional, Picheth, Geraldo, additional, Souza, Emanuel Maltempi, additional, Mitchell, David A., additional, Ambudkar, Suresh V., additional, Nunes, Giovana Gioppo, additional, and Valdameri, Glaucio, additional

Published
2021
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31. Tetrahydroquinoline/4,5‐Dihydroisoxazole Molecular Hybrids as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)

Author

Vesga, Luis C., primary, Kronenberger, Thales, additional, Tonduru, Arun Kumar, additional, Kita, Diogo Henrique, additional, Zattoni, Ingrid Fatima, additional, Bernal, Cristian Camilo, additional, Bohórquez, Arnold R. Romero, additional, Mendez‐Sánchez, Stelia Carolina, additional, Ambudkar, Suresh V., additional, Valdameri, Glaucio, additional, and Poso, Antti, additional

Published
2021
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32. Multiplexed Flow Cytometric Approach for Detection of Anti-SARS-CoV-2 IgG, IgM and IgA Using Beads Covalently Coupled to the Nucleocapsid Protein

Author

Zattoni, Ingrid Fatima, primary, Huergo, Luciano F., primary, Gerhardt, Edileusa C. M., primary, Nardin, Jeanine M., primary, Santos, Alexia Marques Fernandes dos, primary, Rego, Fabiane Gomes de Moraes, primary, Picheth, Geraldo, primary, Moure, Vivian Rotuno, primary, and Valdameri, Glaucio, primary

Published
2021
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36. Identification of a new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP/ABCG2)

Author

Zattoni, Ingrid Fatima, Kronenberger, Thales, Kita, Diogo Henrique, Guanaes, Lais Danciguer, Guimarães, Matheus Murmel, Prado, Larissa de Oliveira, Ziasch, Melanie, Vesga, Luis Carlos, Picheth, Gerlado, Gonçalves, Marcos Brown, Noseda, Miguel, Poso, Antti, Robey, Robert W., Ambudkar, Suresh V., Moure, Vivian Rotuno, Gonçalves, Alan Guilherme, and Valdameri, Glaucio

Subjects
animal structures, Cancer, multidrug resistance, ABC transporters, porphyrins, ABCG2 inhibitors
Abstract

ABCG2 transporter molecular dynamics simulation data with substrate/inhibitors PHE and POR (3 replicas of 1 microsecond each), in explicit membrane/water systems, description regarding execution is provided in the respective manuscript &nbsp

Published
2020
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37. Biological evaluation of Tetrahydroquinoline/4,5-dihydroisoxazole Molecular Hybrids as novel inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)

Author

Vesga, Luis Carlos, Kronenberger, Thales, Tonduru, Arun Kumar, Kita, Diogo Henrique, Zattoni, Ingrid Fatima, Bernal, Cristian Camilo, Bohórquez, Arnold R. Romero, Mendez-Sánchez, Stelia Carolina, Ambudkar, Suresh V., Valdameri, Glaucio, and Poso, Antti

Subjects
ABCG2, Tetrahydroquinolines, Molecular Hybrids, ABC transporter, Molecular Dynamics simulation
Abstract

ABCG2 transporter molecular dynamics simulation data.

Published
2020
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42. Polyoxovanadates as new P-glycoprotein inhibitors: insights into the mechanism of inhibition.

Author

Henrique Kita, Diogo, Alves de Andrade, Gisele, Morais Missina, Juliana, Postal, Kahoana, Boell, Viktor Kalbermatter, Sousa Santana, Francielli, Fatima Zattoni, Ingrid, da Silva Zanzarini, Isadora, Rotuno Moure, Vivian, de Moraes Rego, Fabiane Gomes, Picheth, Geraldo, Maltempi de Souza, Emanuel, Mitchell, David A., Ambudkar, Suresh V., Gioppo Nunes, Giovana, and Valdameri, Glaucio

Subjects
ATP-binding cassette transporters, P-glycoprotein, MULTIDRUG resistance, RHODAMINE B, ADENOSINE triphosphatase
Abstract

A promising strategy to overcome multidrug resistance is the use of inhibitors of ABC drug transporters. For this reason, we evaluated the polyoxovanadates (POVs) [V10O28]6-(V10), [H6V14O38(PO4)]5-(V14), [V15O36Cl]6-(V15) and [V18O42I]7-(V18) as inhibitors of three major multidrug resistance-linked ABC transporters: P-glycoprotein (P-gp), ABCG2 and MRP1. All of the POVs selectively inhibited P-gp. V10 and V18 were the two most promising compounds, with IC50 values of transport inhibition of 25.4 and 22.7 µM, respectively. Both compounds inhibited P-gp ATPase activity, with the same IC50 value of 1.26 µM. V10 and V18 triggered different conformational changes in the P-gp protein with time-dependent inhibition, which was confirmed using the synthesized salt of V10 with rhodamine B, RhoB-V10. The hydrophilic nature of POVs supports the hypothesis that these compounds target an unusual ligand-binding site, opening new possibilities in the development of potent modulators of ABC transporters. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract ofNasturtium officinale: A randomized, double‐blind, and placebo‐controlled trial

Author

Clemente, Mirna, primary, Miguel, Marilis D, additional, Felipe, Karina B, additional, Gribner, Caroline, additional, F Moura, Paula, additional, R Rigoni, Ana Angelica, additional, B Parisotto, Eduardo, additional, T Piltz, Marina, additional, Valdameri, Glaucio, additional, Henneberg, Railson, additional, B Schonhofen, Christian, additional, S Carvalho, João Luiz, additional, Fernandes, Luiz Claudio, additional, and G Miguel, Obdúlio, additional

Published
2020
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47. Proteomic and Metabolomic Analysis of Azospirillum brasilense ntrC Mutant under High and Low Nitrogen Conditions

Author

Kukolj, Caroline, primary, Pedrosa, Fábio O., additional, de Souza, Gustavo A., additional, Sumner, Lloyd W., additional, Lei, Zhentian, additional, Sumner, Barbara, additional, do Amaral, Fernanda P., additional, Juexin, Wang, additional, Trupti, Joshi, additional, Huergo, Luciano F., additional, Monteiro, Rose Adele, additional, Valdameri, Glaucio, additional, Stacey, Gary, additional, and de Souza, Emanuel M., additional

Published
2019
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49. The ammonium transporter AmtB and the PII signal transduction protein GlnZ are required to inhibit DraG in Azospirillum brasilense

Author

Moure, Vivian R., primary, Siöberg, Catrine L. B., additional, Valdameri, Glaucio, additional, Nji, Emmanuel, additional, Oliveira, Marco Aurelio S., additional, Gerdhardt, Edileusa C. M., additional, Pedrosa, Fabio O., additional, Mitchell, David A., additional, Seefeldt, Lance C., additional, Huergo, Luciano F., additional, Högbom, Martin, additional, Nordlund, Stefan, additional, and Souza, Emanuel M., additional

Published
2019
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50. Biomarkers of oxidative stress and inflammation in people witha physical disability treated with a standardized extract of Nasturtium officinale: A randomized, double-blind, and placebo-controlled trial.

Author

Clemente, Mirna, Miguel, Marilis D, Felipe, Karina B, Gribner, Caroline, Moura, Paula, Rigoni, Ana Angelica, Parisotto, Eduardo, Piltz, Marina, Valdameri, Glaucio, Henneberg, Railson, Schonhofen, Christian, Carvalho, João Luiz, Fernandes, Luiz Claudio, Miguel, Obdúlio, F Moura, Paula, R Rigoni, Ana Angelica, B Parisotto, Eduardo, T Piltz, Marina, B Schonhofen, Christian, and S Carvalho, João Luiz

Abstract

It is well established that plants from the Brassicaceae family, particularly watercress, have been associated to reduce oxidative DNA damage. Nasturtium officinale R. Br (watercress) contains glucosinolates, with anti-inflammatory action and protective effect on human health against oxidative stress. We aimed to evaluate whether the standardized extract of Nasturtium officinale (SENO) is capable of changing biomarkers of oxidative stress and inflammation in people with physical disabilities. 65 people enrolled this study: as a control group composed by; 15 people with no physical disability assessed once, 25 people with physical disabilities using 750 mg/kg/day of SENO, and 25 people with physical disabilities using 750 mg/kg/day of placebo-control for 5 weeks. Biomarkers of oxidative stress and inflammation were analyzed on day 0 and 36. The results indicated that SENO was associated with decreasing levels of lipid peroxidation, protein carbonyl, catalase, superoxide dismutase, and C-reactive protein. Furthermore, the cytokine kit demonstrated below and out of invertible range, which was impossible to detect the inflammatory process. Despite the cytokine kit was not able to detect the inflammation; these data might provide supportive evidence that SENO, have affected positively people with physical disabilities decreasing their biomarkers of oxidative stress and C-reactive protein. Further studies are required. [ABSTRACT FROM AUTHOR]

Published
2020
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