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5 results on '"Valadao, Ana‐Luiza Chaves"'

1. DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma

Author

Taffoni, Clara, Marines, Johanna, Chamma, Hanane, Guha, Soumyabrata, Saccas, Mathilde, Bouzid, Amel, Valadao, Ana‐Luiza Chaves, Maghe, Clément, Jardine, Jane, Park, Mi Kyung, Polak, Katarzyna, De Martino, Mara, Vanpouille‐Box, Claire, Del Rio, Maguy, Gongora, Celine, Gavard, Julie, Bidère, Nicolas, Song, Min Sup, Pineau, Donovan, Hugnot, Jean‐Philippe, Kissa, Karima, Fontenille, Laura, Blanchet, Fabien P, Vila, Isabelle K, and Laguette, Nadine

Published
2023
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2. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

Author

Planès, Rémi, Pinilla, Miriam, Santoni, Karin, Hessel, Audrey, Passemar, Charlotte, Lay, Kenneth, Paillette, Perrine, Valadão, Ana-Luiza Chaves, Robinson, Kim Samirah, Bastard, Paul, Lam, Nathaniel, Fadrique, Ricardo, Rossi, Ida, Pericat, David, Bagayoko, Salimata, Leon-Icaza, Stephen Adonai, Rombouts, Yoann, Perouzel, Eric, Tiraby, Michèle, Zhang, Qian, Cicuta, Pietro, Jouanguy, Emmanuelle, Neyrolles, Olivier, Bryant, Clare E., Floto, Andres R., Goujon, Caroline, Lei, Franklin Zhong, Martin-Blondel, Guillaume, Silva, Stein, Casanova, Jean-Laurent, Cougoule, Céline, Reversade, Bruno, Marcoux, Julien, Ravet, Emmanuel, and Meunier, Etienne

Published
2022
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3. DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma

Author

Taffoni, Clara, primary, Marines, Johanna, additional, Chamma, Hanane, additional, Guha, Soumyabrata, additional, Saccas, Mathilde, additional, Bouzid, Amel, additional, Valadao, Ana‐Luiza Chaves, additional, Maghe, Clément, additional, Jardine, Jane, additional, Park, Mi Kyung, additional, Polak, Katarzyna, additional, De Martino, Mara, additional, Vanpouille‐Box, Claire, additional, Del Rio, Maguy, additional, Gongora, Celine, additional, Gavard, Julie, additional, Bidère, Nicolas, additional, Song, Min Sup, additional, Pineau, Donovan, additional, Hugnot, Jean‐Philippe, additional, Kissa, Karima, additional, Fontenille, Laura, additional, Blanchet, Fabien P, additional, Vila, Isabelle K, additional, and Laguette, Nadine, additional

Published
2022
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5. 2´,3´-Dialdehyde of ATP, ADP, and adenosine inhibit HIV-1 reverse transcriptase and HIV-1 replication.

Author

Schachter J, Valadao AL, Aguiar RS, Barreto-de-Souza V, Rossi AD, Arantes PR, Verli H, Quintana PG, Heise N, Tanuri A, Bou-Habib DC, and Persechini PM

Subjects
Adenosine Triphosphate pharmacology, Cells, Cultured, HIV Reverse Transcriptase metabolism, HIV-1 enzymology, HIV-1 physiology, Humans, Macrophages virology, Adenosine pharmacology, Adenosine Diphosphate pharmacology, Adenosine Triphosphate analogs & derivatives, Anti-HIV Agents pharmacology, HIV Infections drug therapy, HIV Reverse Transcriptase antagonists & inhibitors, HIV-1 drug effects, Virus Replication drug effects
Abstract

The 2´3´-dialdehyde of ATP or oxidized ATP (oATP) is a compound known for specifically making covalent bonds with the nucleotide-binding site of several ATP-binding enzymes and receptors. We investigated the effects of oATP and other oxidized purines on HIV-1 infection and we found that this compound inhibits HIV-1 and SIV infection by blocking early steps of virus replication. oATP, oxidized ADP (oADP), and oxidized Adenosine (oADO) impact the natural activity of endogenous reverse transcriptase enzyme (RT) in cell free virus particles and are able to inhibit viral replication in different cell types when added to the cell cultures either before or after infection. We used UFLC-UV to show that both oADO and oATP can be detected in the cell after being added in the extracellular medium. oATP also suppresses RT activity and replication of the HIV-1 resistant variants M184V and T215Y. We conclude that oATP, oADP and oADO display anti HIV-1 activity that is at in least in part due to inhibitory activity on HIV-1 RT.

Published
2014
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