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5 results on '"Valérie Agasse-Peulon"'

1. Comparison of new approach of GC-HRMS (Q-Orbitrap) to GC–MS/MS (triple-quadrupole) in analyzing the pesticide residues and contaminants in complex food matrices

Author

Aude De Sloovere, Wafa Zaghouani, Pascal Cardinael, Martin Vivier, Valérie Agasse-Peulon, Saida Belarbi, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)

Subjects
Food Contamination, Orbitrap, 01 natural sciences, Gas Chromatography-Mass Spectrometry, Analytical Chemistry, law.invention, 0404 agricultural biotechnology, law, Tandem Mass Spectrometry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Vegetables, Pesticides, ComputingMilieux_MISCELLANEOUS, Detection limit, Chromatography, Pesticide residue, Chemistry, 010401 analytical chemistry, Selected reaction monitoring, Pesticide Residues, 04 agricultural and veterinary sciences, General Medicine, Pesticide, Contamination, 040401 food science, 0104 chemical sciences, Triple quadrupole mass spectrometer, Fruit, Gas chromatography–mass spectrometry, Food Science
Abstract

Performances of multiresidue analysis of one hundred of pesticides and contaminants, using GC-Q-Orbitrap method in full scan mode were compared to those obtained with GC-triple-quadrupole method in multiple reaction monitoring mode. In terms of sensitivity, 86% of molecules exhibited lower limit of detection values using GC-Q-Orbitrap than using GC-triple-quadrupole. For the GC-Q-Orbitrap method, more than 85% of the pesticides and contaminants showed good recovery [70-120%] in wheat samples, with relative standard deviation values 20%. GC-Q-Orbitrap method appeared the most sensitive for most pesticides studied in wheat with limit of quantification values ranged between 0.1 µg/kg and 4 µg/kg. Moreover, the matrix effect was acceptable in wheat extracts for 84 molecules but strong suppression of the chromatographic signal was observed for 16 molecules for the GC-Q-Orbitrap method. The injection of unpurified wheat extracts spiked at 10 µg/kg proved the potential of the GC-Q-Orbitrap method for use in performing high-throughput pesticide screening.

Published
2021
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2. Incorporation of Imidazolium Ionic Liquids in GC Stationary Phases via the Sol–Gel Process

Author

Séverine Tisse, Valérie Agasse-Peulon, Pascal Cardinael, Aurélien Curat, Didier Villemin, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire de chimie moléculaire et thioorganique (LCMT), Centre National de la Recherche Scientifique (CNRS)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU), and Propre

Subjects
chemistry.chemical_classification, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010401 analytical chemistry, Organic Chemistry, Clinical Biochemistry, Analytical chemistry, Polymer, [CHIM.MATE]Chemical Sciences/Material chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, chemistry.chemical_compound, [CHIM.POLY]Chemical Sciences/Polymers, chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Ionic liquid, Structural isomer, Polar, Thermal stability, Counterion, Derivative (chemistry), Sol-gel
Abstract

Room-temperature ionic liquids (RTILs) have proven to be efficient polar or highly polar stationary phases for GC. Nevertheless, the thermal stability of monocationic RTILs limits their use in high-temperature GC. To improve the thermal stability, an RTIL based on a 1-methylimidazolium derivative was anchored in a three-dimensional network using the sol–gel process. Three different strategies were compared: using the derivative pure, in combination with a polymer or copolymerised with diethoxydimethylsilane. This last method allowed for the preparation of hybrid stationary phases with satisfactory efficiency (3500 plates per meter determined by the injection of n-tetradecane at 80 °C, k = 8.19) and very good thermal stability up to 340 °C using the NTf2 counter ion. The stationary phases demonstrated a good ability to separate positional isomers and polycyclic aromatic hydrocarbons. Polarity and molecular interactions with analytes were characterized by calculating the Rohrschneider–McReynolds constants and Abraham system constants. A classification of the polarity of the new stationary phases relative to 44 stationary phases, including commercial and non-commercial ones, was performed based on the RTILs using principal component analysis. Finally, the maximal operating temperature of these new stationary phases was compared with those of the most thermally stable conventional or RTIL-based stationary phases, demonstrating that the sol–gel process is an efficient way to enhance the thermal stability of GC stationary phases.

Published
2020
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3. Development of two-dimensional gas chromatography (GC×GC) coupled with Orbitrap-technology-based mass spectrometry: Interest in the identification of biofuel composition

Author

Chetna Mohabeer, Bechara Taouk, Marie Vaccaro, Nguyen Viet Hung, Pascal Cardinael, Lokmane Abdelouahed, Valérie Agasse-Peulon, Stéphane Marcotte, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire de Sécurité des Procédés Chimiques (LSPC), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Organique Fine (IRCOF), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Propre, Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut de Chimie Organique Fine (IRCOF), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université Le Havre Normandie (ULH), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Spectrum analyzer, Chemical substance, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Orbitrap, Mass spectrometry, 01 natural sciences, Gas Chromatography-Mass Spectrometry, [SPI.MAT]Engineering Sciences [physics]/Materials, law.invention, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, law, [CHIM.CRIS]Chemical Sciences/Cristallography, Molecule, Cellulose, ComputingMilieux_MISCELLANEOUS, Spectroscopy, Horizontal scan rate, Chromatography, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Chemistry, 010401 analytical chemistry, 0104 chemical sciences, Biofuels, Mass spectrum, Gas chromatography, Pyrolysis
Abstract

International audience; Comprehensive gas chromatography (GC) has emerged in recent years as the technique of choice for the analysis of volatile and semivolatile compounds in complex matrices. Coupling it with high‐resolution mass spectrometry (MS) makes a powerful tool for identification and quantification of organic compounds. The results obtained in this study showed a significant improvement by using GC×GC‐EI‐MS in comparison with GC‐EI‐MS; the separation of chromatogram peaks was highly improved, which facilitated detection and identification. However, the limitation of Orbitrap mass analyzer compared with time‐of‐flight analyzer is the data acquisition rate; the frequency average was about 25 Hz at a mass resolving power of 15.000, which is barely sufficient for the proper reconstruction of the narrowest chromatographic peaks. On the other hand, the different spectra obtained in this study showed an average mass accuracy of about 1 ppm. Within this average mass accuracy, some reasonable elemental compositions can be proposed and combined with characteristic fragment ions, and the molecules can be identified with precision. At a mass resolving power of 7.500, the scan rate reaches 43 Hz and the GC×GC‐MS peaks can be represented by more than 10 data points, which should be sufficient for quantification. The GC×GC‐MS was also applied to analyze a cellulose bio‐oil sample. Following this, a highly resolved chromatogram was obtained, allowing EI mass spectra containing molecular and fragment ions of many distinct molecules present in the sample to be identified.

Published
2020
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4. Enhanced Second Harmonic Generation from an Organic Self-Assembled Eutectic Binary Mixture: A Case Study with 3-Nitrobenzoic and 3,5-Dinitrobenzoic Acids

Author

Valérie Dupray, Gérard Coquerel, Morgane Sanselme, Nicolas Couvrat, Gabin Gbabode, F. Simon, Simon Clevers, Valérie Agasse-Peulon, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), and Propre

Subjects
Work (thermodynamics), Materials science, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Analytical chemistry, Binary number, Second-harmonic generation, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Second Harmonic Generation Microscopy, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Condensed Matter Physics, Self assembled, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM]Chemical Sciences, General Materials Science, ComputingMilieux_MISCELLANEOUS, Eutectic system
Abstract

This work illustrates the use of powder second harmonic generation (powder SHG), temperature-resolved second harmonic generation (TR-SHG), and second harmonic generation microscopy (SHGM) in monoph...

Published
2015
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5. Comparison between conventional and comprehensive GC for the search of 58 target compounds and screening of undesiderable polluants in an environmental complex matrix

Author

Gaëlle Semard, Auguste Bruchet, Pascal Cardinael, Valérie Agasse-Peulon, P Bouillon, J., Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Theo Van den Hoven, Christian Kazner, and Lemercier, Aurélien

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

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