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A reproducibility study of the paper: Context and Attribute-Aware Sequential Recommendation via Cross-Attention, {"references":["https://paperswithcode.com/paper/carca-context-and-attribute-aware-next-item"]}

Supplemental material, sj-pdf-2-jhs-10.1177_1753193420970155 for Current national hand surgery registries worldwide by Konstantinos Vakalopoulos, Marianne Arner, Geke Denissen, Jeremy Rodrigues, Michael Schädel-Höpfner, Yngvar Krukhaug, Richard Page and Anne Lübbeke in Journal of Hand Surgery (European Volume)

Supplemental material, sj-pdf-3-jhs-10.1177_1753193420970155 for Current national hand surgery registries worldwide by Konstantinos Vakalopoulos, Marianne Arner, Geke Denissen, Jeremy Rodrigues, Michael Schädel-Höpfner, Yngvar Krukhaug, Richard Page and Anne Lübbeke in Journal of Hand Surgery (European Volume)

Supplemental material, sj-pdf-1-jhs-10.1177_1753193420970155 for Current national hand surgery registries worldwide by Konstantinos Vakalopoulos, Marianne Arner, Geke Denissen, Jeremy Rodrigues, Michael Schädel-Höpfner, Yngvar Krukhaug, Richard Page and Anne Lübbeke in Journal of Hand Surgery (European Volume)

Background: Anastomotic leakage (AL) remains an important complication after colorectal surgery. Experimental research aims to find a solution to overcome this serious complication; however, no validated AL model exists in the rat. This study was designed to develop a feasible new, reproducible AL model for use in colorectal anastomotic research. Methods: Forty-four male Wistar rats, randomly divided into 4 groups, underwent a midline laparotomy and transection of the proximal colon. An anastomosis was created with 3, 4, 5, or 12 (control) sutures. After 7 days, the rats were euthanized and scored for the presence of AL. The secondary outcomes were anastomotic bursting pressure (ABP), histological evaluation, and maturation of collagen. After the initial experiment, the AL model was reproduced in an external academic center to ensure reproducibility. Results: AL occurred in 68.8% of rats treated with an insufficient anastomosis, compared to 10% of the control group (P=0.005). AL rates were highest (81.8%) in the 3-suture group and lowest (50%) when 5 sutures were used. The experiment with 4 sutures was reproduced at an external academic center and showed similar AL rates as in our center (72.7% vs. 63.6%). Conclusions: Our rat model for inducing AL by creating an anastomosis using an insufficient number of sutures is feasible and reproducible. When combining all outcome measures, the AL model for colorectal leakage using 4 sutures is the most suitable for use in future research.

Background: Tissue adhesives may be useful for sealing bowel anastomoses by preventing anastomotic leakage. Prior to clinical implementation, an in-depth analysis of the clinical and immunohistopathological effects of tissue adhesives on the target tissue and of the mechanical strength of the adhesive bond in an in vivo model is needed. Materials and methods: In 84 rats, two bowel segments were glued using one of the following tissue adhesive: Bioglue, Gelatin-resorcinol-formaldehyde (GRF), Glubran 2, Histoacryl Flex, Omnex, Duraseal Xact, or Tissucol. Rats were followed for 7 or 28 days. Endpoints were clinical complication rate, mechanical strength, and immunohistopathological reactions. Results: Of the seven tissue adhesives, GRF and Bioglue showed the highest rates of bowel wall destruction and ileus and the most severe immunohistopathological tissue reactions at 7 and 28 days. Cyanoacrylates (Histoacryl Flex, Omnex, Glubran 2) showed high mechanical strength and mild immunohistopathological reactions at 7 and 28 days. Duraseal Xact and Tissucol were the most inert tissue adhesives, but exhibited low mechanical strength. At 28 days, mechanical strength was significantly correlated to CD8, CD68, and Ki67 cell counts. Conclusion: Based on the clinical and immunohistopathological outcomes, GRF and Bioglue were found to be the least suitable tissue adhesives for colonic use. Duraseal Xact and Tissucol were inert but also showed low mechanical strength. Cyanoacrylates exhibited mild clinical and immunohistopathological effects while maintaining high strength, which makes them promising as colonic sealants.

Background Although cyanoacrylate glue (CA) has been widely used in various kinds of medical applications, its application in gastrointestinal anastomosis remains limited, and outcomes of experimental studies have not been satisfactory. This systematic review summarizes research regarding CA application in intestinal and colorectal anastomosis, and correlates methodological aspects to experimental outcomes. Methods A systematic literature search was performed using Medline, Embase, Cochrane, and Web-of-Science libraries. Articles were selected if CA was applied to intestinal or colorectal anastomoses. Included articles were categorized according to CA molecular structure; the method details in each study were extracted and analyzed. Results Twenty-two articles were included. More than half of the inclusions reported positive outcomes (seven articles) or neutral outcomes (eight articles). Analysis of the methods revealed that methodological details such as CA dosage, time of polymerization were not consistently reported. Porcine studies, inverted anastomosis, and n-butyl-cyanoacrylate studies showed more positive outcomes; everted anastomosis, and oversized sutures might negatively influence the outcomes. Conclusions Owing to the positive outcome from the porcine studies, application of CA in gastrointestinal (GI) anastomosis still seems promising. To achieve a better consistency, more methodological details need to be provided in future studies. Optimizing the dosage of CA, choice of animal model, inverted anastomosis construction, and other method details may improve intestinal and colorectal anastomoses with CA application in future studies. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 102B: 635-642, 2014.