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2. Consideration of hereditary effects in the radiological protection system: evolution and current status.

Author

Amrenova, A., Ainsbury, E., Baudin, C., Giussani, A., Lochard, J., Rühm, W., Scholz-Kreisel, P., Trott, K., Vaillant, L., Wakeford, R., Zölzer, F., and Laurier, D.

Subjects
SCIENTIFIC knowledge, IONIZING radiation, RADIATION exposure, HUMAN genetics, FREQUENCY stability
Abstract

Purpose: The purpose of this paper is to provide an overview of the methodology used to estimate radiation genetic risks and quantify the risk of hereditary effects as outlined in the ICRP Publication 103. It aims to highlight the historical background and development of the doubling dose method for estimating radiation-related genetic risks and its continued use in radiological protection frameworks. Results: This article emphasizes the complexity associated with quantifying the risk of hereditary effects caused by radiation exposure and highlights the need for further clarification and explanation of the calculation method. As scientific knowledge in radiation sciences and human genetics continues to advance in relation to a number of factors including stability of disease frequency, selection pressures, and epigenetic changes, the characterization and quantification of genetic effects still remains a major issue for the radiological protection system of the International Commission on Radiological Protection. Conclusion: Further research and advancements in this field are crucial for enhancing our understanding and addressing the complexities involved in assessing and managing the risks associated with hereditary effects of radiation. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Le principe de limitation des doses et la tolérabilité du risque radiologique

Author

Vaillant, L. and Vaillant, L.

Abstract

Le système de radioprotection vise à protéger l’homme et l’environnement contre les effets nocifs liés à l’exposition aux rayonnements ionisants. Il repose sur 3 principes de gestion : le principe de justification, le principe d’optimisation de la protection et l’application des limites de dose. En ce qui concerne la santé humaine, l’objectif du système est, plus précisément, de prévenir les réactions tissulaires et de maintenir la probabilité d’effets stochastiques à un niveau acceptable, compte-tenu des caractéristiques de la situation d’exposition. Pour les situations d’exposition planifiées, hors exposition médicale, la fixation de limites de dose est nécessaire, non seulement pour atteindre le premier objectif, mais aussi pour contribuer au second. Depuis 1928, la Commission Internationale de Protection Radiologique a développé un système de protection radiologique fondé sur la science, les valeurs et l’expérience, et qui comprend, entre autres, des recommandations portant sur les limites de dose. Cet article a pour but d’explorer la rationalité des valeurs de limites de dose proposées par la Commission.

Published
2024
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6. The Clinical Significance of Urinary Neopterin in the Follow-up of Patients after Exeresis of a Malignant Melanoma

Author

Mura P., Barriere M., Papet Y., Reiss D., Camenen I., Vaillant L., and Lorette G.

Subjects
Crystallography, QD901-999
Abstract

Serial urinary neopterin determinations were performed in 151 patients after exeresis of a malignant melanoma. Values for patients clinically free of disease at the end of the observation were similar to those of healthy subjects. No significant varia tions were observed in patients with cutaneous meta stases. The most important variations were found in patients who developed ganglionic and above all visceral metastases. These data suggest that neopterin determination could be very useful in the follow-up of patients with a malignant melanoma and especially for detecting visceral metastases occurences.

Published
1989
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15. L’analyse du métabolome salivaire révèle des variations du métabolisme de la tyrosine chez des patients atteints de stomatodynie primaire : étude prospective cas-témoins

Author

Moreau, C., primary, El Habnouni, C., additional, Lecron, J.C., additional, Morel, F., additional, Delwail, A., additional, Le Gall-Ianotto, C., additional, Le Garrec, R., additional, Misery, L., additional, Piver, E., additional, Vaillant, L., additional, Lefevre, A., additional, Emond, P., additional, Blasco, H., additional, and Samimi, M., additional

Published
2022
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20. An overview of Internet biosurveillance

Author

Hartley, D.M., Nelson, N.P., Arthur, R.R., Barboza, P., Collier, N., Lightfoot, N., Linge, J.P., van der Goot, E., Mawudeku, A., Madoff, L.C., Vaillant, L., Walters, R., Yangarber, R., Mantero, J., Corley, C.D., and Brownstein, J.S.

Published
2013
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25. The Efficacy of Cancer Immunotherapies Is Compromised by Helicobacter pylori Infection

Author

Oster, P., Vaillant, L., McMillan, B., and Velin, D.

Subjects
Gastric Mucosa, Helicobacter Infections/complications, Helicobacter pylori, Humans, Immunotherapy/adverse effects, Lymphoma, B-Cell, Marginal Zone/pathology, cancer, gut microbiota, immune checkpoint inhibitors, immunotherapy, personalized medicine
Abstract

Helicobacter pylori infects the gastric mucosa of a large number of humans. Although asymptomatic in the vast majority of cases, H pylori infection can lead to the development of peptic ulcers gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Using a variety of mechanisms, H pylori locally suppresses the function of the host immune system to establish chronic infection. Systemic immunomodulation has been observed in both clinical and pre-clinical studies, which have demonstrated that H pylori infection is associated with reduced incidence of inflammatory diseases, such as asthma and Crohn's disease. The introduction of immunotherapies in the arsenal of anti-cancer drugs has revealed a new facet of H pylori-induced immune suppression. In this review, we will describe the intimate interactions between H pylori and its host, and formulate hypothtyeses describing the detrimental impact of H pylori infection on the efficacy of cancer immunotherapies.

Published
2022

29. Controlling healthcare-associated transmission of SARS-CoV-2 variant of concern 202012/01 in a large hospital network

Author

Duverger, C., primary, Souyri, V., additional, Monteil, C., additional, Fournier, S., additional, Espinasse, F., additional, Gramer, M.C., additional, Lepainteur, M., additional, Seytre, D., additional, Zahar, J.R., additional, Nerome, S., additional, Ciotti, C., additional, Garrigues, I., additional, Delaby, M.L., additional, Fortineau, N., additional, Ouzani, S., additional, Kecharem, M., additional, Lucet, J.C., additional, Kernéis, S., additional, Géra, S., additional, Bendjelloul, G., additional, Vaillant, L., additional, Vanderbrugghe, M., additional, Goldstein, V., additional, Loison, C., additional, Borde, S., additional, Moulin, V., additional, Leboydre, C., additional, Derouin, V., additional, Casetta, A., additional, Meyer, L., additional, Akpabie, A., additional, Kassis-Chikhani, N., additional, Maurand, A., additional, Silvie, M., additional, Decousser, J.W., additional, Fourreau, F., additional, Hacquin, B., additional, Tackin, A., additional, Lomont, A., additional, Sabourin, N., additional, Amarsy, R., additional, Roulleau, S., additional, Boufflers, Y., additional, Idri, N., additional, Frange, P., additional, Baune, P., additional, Robert, J., additional, Osinski, N., additional, Tamames, C., additional, Auraix, J., additional, Forest, N., additional, Pierson, E., additional, Lawrence, C., additional, Flament, C., additional, Rolland, G., additional, Mariani, P., additional, Belhacel, K., additional, Salauze, B., additional, Barbut, F., additional, Jolivet, S., additional, Audrain, N., additional, Simon, I., additional, Turpin, L., additional, Rouveau, M., additional, Le Cam, M.T., additional, Eble, C., additional, Zebiche, W., additional, Simha, V., additional, Grudzien, C., additional, Denis, M., additional, Le-Roux, E., additional, Angerand, S., additional, and Charpinet, C., additional

Published
2021
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36. Macrochéilite granulomateuse : efficacité des traitements systémiques dans une série rétrospective multicentrique de 61 patients

Author

Jaouen, F.Y., primary, Tessier, M.-H., additional, Vaillant, L., additional, Azib-Meftah, S., additional, Misery, L., additional, Beneton, N., additional, Delaporte, E., additional, Kaddour, A., additional, Oro, S., additional, Nahon, S., additional, Masson Regnault, M., additional, Sibaud, V., additional, Fricain, J.-C., additional, Bessis, D., additional, Girard, C., additional, and Samimi, M., additional

Published
2020
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39. Liste des Collaborateurs de la 3e Édition

Author

Blond, M.-H., primary, Cissoko, H., additional, De Courtivron, B., additional, De Montgolfier, I., additional, Despert, F., additional, Gold, F., additional, Jonville-Béra, A.-P., additional, Lionnet, C., additional, Tietche, F., additional, Vaillant, L., additional, Vaillant, M.-C., additional, Ajam, É., additional, Burguet, A., additional, Favre, A., additional, Goudeau, A., additional, Le Touze, A., additional, and Saillant, D., additional

Published
2009
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46. Photoluminescence studies of CdS films grown by close-spaced vapor transport hot walls

Author

Mejia-Garcia, C., Escamilla-Esquivel, A., Contreras-Puente, G., Tufino-Velazquez, M., Albor-Aguilera, M.L., Vigil, O., and Vaillant, L.

Subjects
Photoluminescence -- Research, Semiconductor films -- Research, Physics
Abstract

Research was conducted to investigate semiconducting films of CdS developed by a modified close-spaced vapor transport hot-wall method via photoluminescence in the range of 10-300 K. Measurements of photoluminescence on CdS films processed by a modified close-spaced vapor transport hot-wall (CSVT-HW) technique with different substrate temperatures and fixed source temperature were carried out for a wide range of temperatures. Results demonstrate that the CSVT-HW is an important approach to achieve semiconductor thin films with good crystalline quality.

Published
1999

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