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2. Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer : TARGIT-A randomised clinical trial

Author

Vaidya, Jayant S, Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik L, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R, Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Le Blanc-Onfroy, Magali, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J, Niewald, Marcus, Blohmer, Jens, McCready, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David J, and Tobias, Jeffrey S

Published
2020

4. New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer

Author

Vaidya, Jayant S., Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R., Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Blanc-Onfroy, Magali Le, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J., Niewald, Marcus, Blohmer, Jens, McReady, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David, and Tobias, Jeffrey S.

Published
2021
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6. Beliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study

Author

Adamson, Vanessa, Ainsworth, Sarah, Akerlund, Malin, Baker, Ivanna, Barwell, Julian, Beesley, Jayne, Brock, Lisa, Butcher, Chrissie, Carpenter, Janice, Clark, Martyn, Cocks, Shirley, Conteh, Veronica, Coulding, Martina, Darby, Sue, Duckworth, Angela, Evans, Gareth, Fensom, Catherine, Fletcher, Julie, Foster, Kate, Grieg, Sara, Gullaksen, Elaine, Gurasashvili, Jana, Hardstaff, Lisa, Hart, Rachel, Hoare, Kathryn, Hoffman, Jonathan, Holcombe, Christopher, Horton, Lynne, Howell, Antony, Islam, Farah, Jenkinson, Emma, Jewers, Karen, Joshi, Manisha, Kirkby, Amy, Kneeshaw, Peter, Knife, Natalie, Kokan, Jalal, Li, Jin, Lunt, Nicola, Macmillan, Douglas, Makinson, Karen, Mallidis, Evangelos, Manyangadze, Sarah, Masvaure, Charity, Mistry, Raksha, Ngumo, Alice, Ooi, Jane, Patel, Ashraf, Pope, Vanessa, Price, Laura, Rabson, Fiona, Richardson, Lisa, Ridgway, Stephanie, Riley, Karen, Roberts, Lorraine, Ryan-Smith, Janet, Salih, Vian, Scott, Nicky, Shere, Mike, Sloan, Andrew, Solanky, Nita, Taylor, Amanda, Thekkinkattil, Dinesh, Thomas, Heather, Thorat, Mangesh, Townley, Barbara, Vaidya, Jayant S., Wagstaff, Lynda, Walsh, Shane, Waring, Lynsey, Watterson, Donna, Westley, Charlotte, Wilkinson, Lesley, Willis, Nicola, Wiseman, Julia, Thorneloe, Rachael Jane, Horne, Rob, Side, Lucy, Wolf, Michael Scott, and Smith, Samuel George

Published
2019
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8. Opportunities and priorities for breast surgical research

Author

Basu, Narendra N, Benson, John R, Bundred, Nigel J, Carmichael, Amtul R, Coombs, Nathan, Cutress, Ramsey I, Dickson, John, Dixon, J Michael, Douek, Michael, Fairbrother, Patricia, Francis, Adele, Goyal, Amit, Harcourt, Diana, Harvey, James, Holcombe, Chris, Horsnell, Jonathan, Iqbal, Fahad M, Khan, Lucy R, Kirwan, Cliona C, Leff, Daniel R, Maxwell, Anthony J, McIntosh, Stuart A, Paraskeva, Nicole, Potter, Shelley, Rattay, Tim, Reed, Malcolm WR, Sami, Amtul S, Singer, Julian, St John, Edward R, Subramanian, Ash, Tobias, Jeffrey S, Touqan, Nader, Vaidya, Jayant S, Vidya, Raghavan, Winters, Zoe E, and Reed, Malcolm W R

Published
2018
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12. Supplementary Data from Targeted Intraoperative Radiotherapy Impairs the Stimulation of Breast Cancer Cell Proliferation and Invasion Caused by Surgical Wounding

Author

Belletti, Barbara, primary, Vaidya, Jayant S., primary, D'Andrea, Sara, primary, Entschladen, Frank, primary, Roncadin, Mario, primary, Lovat, Francesca, primary, Berton, Stefania, primary, Perin, Tiziana, primary, Candiani, Ezio, primary, Reccanello, Sonia, primary, Veronesi, Andrea, primary, Canzonieri, Vincenzo, primary, Trovò, Mauro G., primary, Zaenker, Kurt S., primary, Colombatti, Alfonso, primary, Baldassarre, Gustavo, primary, and Massarut, Samuele, primary

Published
2023
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13. Abstract P1-09-04: Comparison of length and quality of life (QoL) and the side effects of therapy between breast conserving surgery with intraoperative radiotherapy (TARGIT-IORT) versus mastectomy for in-breast-recurrence of breast cancer

Author

Kolberg, Hans-Christian, primary, Niesing, Helena, additional, Vaidya, Jayant S, additional, Akpolat-Basci, Leyla, additional, Maguz, Abdrhman, additional, Hoffmann, Oliver, additional, Lövey, György, additional, Stephanou, Miltiades, additional, and Kolberg-Liedtke, Cornelia, additional

Published
2023
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15. In Reply to Ward et al.

Author

Vaidya, Jayant S., primary, Bulsara, Max, additional, Wenz, Frederik, additional, Sperk, Elena, additional, Massarut, Samuele, additional, Alvarado, Michael, additional, Williams, Norman R., additional, Brew-Graves, Chris, additional, Bernstein, Marcelle, additional, Holmes, Dennis, additional, Vinante, Lorenzo, additional, Pigorsch, Steffi, additional, Lundgren, Steiner, additional, Uhl, Valery, additional, Joseph, David, additional, and Tobias, Jeffrey S., additional

Published
2023
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16. The TARGIT-A Randomized Trial: TARGIT-IORT Versus Whole Breast Radiation Therapy: Long-Term Local Control and Survival

Author

Vaidya, Jayant S., primary, Bulsara, Max, additional, Wenz, Frederik, additional, Sperk, Elena, additional, Massarut, Samuele, additional, Alvarado, Michael, additional, Williams, Norman R., additional, Brew-Graves, Chris, additional, Bernstein, Marcelle, additional, Holmes, Dennis, additional, Vinante, Lorenzo, additional, Pigorsch, Steffi, additional, Lundgren, Steinar, additional, Uhl, Valery, additional, Joseph, David, additional, and Tobias, Jeffrey S., additional

Published
2023
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18. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial

Author

Vaidya, Jayant S, Wenz, Frederik, Bulsara, Max, Tobias, Jeffrey S, Joseph, David J, Keshtgar, Mohammed, Flyger, Henrik L, Massarut, Samuele, Alvarado, Michael, Saunders, Christobel, Eiermann, Wolfgang, Metaxas, Marinos, Sperk, Elena, Sütterlin, Marc, Brown, Douglas, Esserman, Laura, Roncadin, Mario, Thompson, Alastair, Dewar, John A, Holtveg, Helle M R, Pigorsch, Steffi, Falzon, Mary, Harris, Eleanor, Matthews, April, Brew-Graves, Chris, Potyka, Ingrid, Corica, Tammy, Williams, Norman R, and Baum, Michael

Published
2014
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27. Breast preservation after local recurrence of breast cancer: Comparison of length and quality of life (QoL) between breast conserving surgery with intraoperative radiotherapy (TARGIT-IORT) versus mastectomy.

Author

Kolberg, Hans-Christian, primary, Niesing, Helena, additional, Vaidya, Jayant S., additional, Akpolat-Basci, Leyla, additional, Maguz, Abdrhman, additional, Hoffmann, Oliver, additional, Loevey, Gyoergy, additional, Stephanou, Miltiades, additional, and Kolberg-Liedtke, Cornelia, additional

Published
2022
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31. Abstract P3-19-16: Impact of targeted intraoperative (TARGIT-IORT) tumor bed boost during breast conserving surgery for early breast cancer on breast cancer associated and non-breast cancer associated mortality and morbidity

Author

Kolberg, Hans-Christin, primary, Gutberlet, Stephanie, additional, Vaidya, Jayant S, additional, Krajewska, Maja, additional, Lövey, György, additional, Hoffmann, Oliver, additional, Stephanou, Miltiades, additional, and Kolberg-Liedtke, Cornelia, additional

Published
2022
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32. Effect of Delayed Targeted Intraoperative Radiotherapy vs Whole-Breast Radiotherapy on Local Recurrence and Survival: Long-term Results From the TARGIT-A Randomized Clinical Trial in Early Breast Cancer

Author

Vaidya, Jayant S, Bulsara, Max, Saunders, Christobel, et al, Gruber, Günther, Dedes, Konstantin J, University of Zurich, and Vaidya, Jayant S

Subjects
610 Medicine & health, 2730 Oncology, 1306 Cancer Research, General Medicine, 10174 Clinic for Gynecology
Published
2020
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33. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial

Author

Vaidya, Jayant S, Joseph, David J, Tobias, Jeffrey S, Bulsara, Max, Wenz, Frederik, Saunders, Christobel, Alvarado, Michael, Flyger, Henrik L, Massarut, Samuele, Eiermann, Wolfgang, Keshtgar, Mohammed, Dewar, John, Kraus-Tiefenbacher, Uta, Sütterlin, Marc, Esserman, Laura, Holtveg, Helle MR, Roncadin, Mario, Pigorsch, Steffi, Metaxas, Marinos, Falzon, Mary, Matthews, April, Corica, Tammy, Williams, Norman R, and Baum, Michael

Published
2010
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35. In Regard to Polgar et al

Author

Vaidya, Jayant S., primary, Bulsara, Max, additional, Sperk, Elena, additional, Massarut, Samuele, additional, Douek, Michael, additional, Alvarado, Michael, additional, Pigorsch, Steffi, additional, Holmes, Dennis, additional, Bernstein, Marcelle, additional, Saunders, Christobel, additional, Flyger, Henrik, additional, Joseph, David, additional, Wenz, Frederik, additional, and Tobias, Jeffrey S., additional

Published
2021
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38. New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer

Author

Vaidya, Jayant S; https://orcid.org/0000-0003-1760-1278, Bulsara, Max, Baum, Michael, et al, Gruber, Günther, Dedes, Konstantin J; https://orcid.org/0000-0002-8741-9319, Vaidya, Jayant S; https://orcid.org/0000-0003-1760-1278, Bulsara, Max, Baum, Michael, et al, Gruber, Günther, and Dedes, Konstantin J; https://orcid.org/0000-0002-8741-9319

Abstract

Background: The TARGIT-A trial reported risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy for breast cancer to be as effective as whole-breast external beam radiotherapy (EBRT). Here, we present further detailed analyses. Methods: In total, 2298 women (≥45 years, invasive ductal carcinoma ≤3.5 cm, cN0-N1) were randomised. We investigated the impact of tumour size, grade, ER, PgR, HER2 and lymph node status on local recurrence-free survival, and of local recurrence on distant relapse and mortality. We analysed the predictive factors for recommending supplemental EBRT after TARGIT-IORT as part of the risk-adapted approach, using regression modelling. Non-breast cancer mortality was compared between TARGIT-IORT plus EBRT vs. EBRT. Results: Local recurrence-free survival was no different between TARGIT-IORT and EBRT, in every tumour subgroup. Unlike in the EBRT arm, local recurrence in the TARGIT-IORT arm was not a predictor of a higher risk of distant relapse or death. Our new predictive tool for recommending supplemental EBRT after TARGIT-IORT is at https://targit.org.uk/addrt . Non-breast cancer mortality was significantly lower in the TARGIT-IORT arm, even when patients received supplemental EBRT, HR 0.38 (95% CI 0.17-0.88) P = 0.0091. Conclusion: TARGIT-IORT is as effective as EBRT in all subgroups. Local recurrence after TARGIT-IORT, unlike after EBRT, has a good prognosis. TARGIT-IORT might have a beneficial abscopal effect. Trial registration: ISRCTN34086741 (21/7/2004), NCT00983684 (24/9/2009).

Published
2021

39. Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment

Author

Vaidya, Jayant S; https://orcid.org/0000-0003-1760-1278, Bulsara, Max, Baum, Michael, Tobias, Jeffrey S, Dedes, Konstantin J, Vaidya, Jayant S; https://orcid.org/0000-0003-1760-1278, Bulsara, Max, Baum, Michael, Tobias, Jeffrey S, and Dedes, Konstantin J

Abstract

SummaryIn the randomised TARGIT-A trial, risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy was non-inferior to whole-breast external beam radiotherapy, for local recurrence. In the long-term, no difference was found in any breast cancer outcome, whereas there were fewer deaths from non-breast-cancer causes. TARGIT-IORT should be included in pre-operative consultations with eligible patients.

Published
2021

47. Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial

Author

Vaidya, Jayant S; https://orcid.org/0000-0003-1760-1278, Bulsara, Max, Baum, Michael, et al, Gruber, Günther, Dedes, Konstantin J, Vaidya, Jayant S; https://orcid.org/0000-0003-1760-1278, Bulsara, Max, Baum, Michael, et al, Gruber, Günther, and Dedes, Konstantin J

Abstract

Objective: To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early breast cancer. Design: Prospective, open label, randomised controlled clinical trial. Setting: 32 centres in 10 countries in the United Kingdom, Europe, Australia, the United States, and Canada. Participants: 2298 women aged 45 years and older with invasive ductal carcinoma up to 3.5 cm in size, cN0-N1, eligible for breast conservation and randomised before lumpectomy (1:1 ratio, blocks stratified by centre) to either risk adapted targeted intraoperative radiotherapy (TARGIT-IORT) or external beam radiotherapy (EBRT). Interventions: Random allocation was to the EBRT arm, which consisted of a standard daily fractionated course (three to six weeks) of whole breast radiotherapy, or the TARGIT-IORT arm. TARGIT-IORT was given immediately after lumpectomy under the same anaesthetic and was the only radiotherapy for most patients (around 80%). TARGIT-IORT was supplemented by EBRT when postoperative histopathology found unsuspected higher risk factors (around 20% of patients). Main outcome measures: Non-inferiority with a margin of 2.5% for the absolute difference between the five year local recurrence rates of the two arms, and long term survival outcomes. Results: Between 24 March 2000 and 25 June 2012, 1140 patients were randomised to TARGIT-IORT and 1158 to EBRT. TARGIT-IORT was non-inferior to EBRT: the local recurrence risk at five year complete follow-up was 2.11% for TARGIT-IORT compared with 0.95% for EBRT (difference 1.16%, 90% confidence interval 0.32 to 1.99). In the first five years, 13 additional local recurrences were reported (24/1140 v 11/1158) but 14 fewer deaths (42/1140 v 56/1158) for TARGIT-IORT compared with EBRT. With long term follow-up (median 8.6 years, maximum 18.90 years, interquartile range 7.0-10.6) no statistically significant difference w

Published
2020

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