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Switched capacitor multilevel inverter topologies are attractive among industrial power electronics researchers due to their applicability in sustainable energy systems such as renewable energy source (RES) applications. In this paper, a new switched capacitor (SC)-based grid-tied seven-level inverter is proposed for renewable energy sources (RES) applications. The proposed inverter can generate a seven-level output voltage waveform with voltage boosting ability and a gain factor of 3. Also, the proposed topology can provide the self voltage balancing for capacitors. The most important challenge of the SC-based topologies, i.e., the capacitor charging spike current, is solved by applying a soft charging circuit in the charging loop of the capacitors. The soft charging circuit consists of an inductor and a power diode in the capacitor charging path. Using a small size inductor in the soft charging circuit, the proposed inverter can limit the input current spikes. Comprehensive experiment results and comparisons are presented to verify the accurate performance of the proposed inverter., DC systems, Energy conversion & Storage

This article presents a detailed procedure for deriving the generalized average model (GAM) of a dual active bridge converter. The proposed model incorporates higher orders of harmonic components to increase accuracy. Moreover, the turn ratio of the high-frequency transformer (N_t) is considered for realistic modeling, which removes the conventional assumption of unity turn ratio. A detailed model of the DAB will ensure an accurate control design. Required mathematical expressions are derived and explained thoroughly, with an example showcasing a GAM model of the DAB converter up to the ninth harmonics. Several GAM models using different harmonic orders (first, third, fifth, seventh, and ninth harmonics) are derived and compared to the PLECS simulation model and a real-time simulation of the DAB converter on the PLECS RT-Box-2. Results show that including up to the ninth harmonics in the proposed model of the DAB converter leads to achieving accurate voltage and current amplitudes that are almost identical to the simulation outputs and even better than the experimental results., DC systems, Energy conversion & Storage

Multilevel converters (MLCs) are widely recognized for their exceptional benefits and have emerged as the preferred choice for medium- and high-power/voltage applications. Their usage has also been extended to low-power applications to overcome issues associated with high switching frequencies and electromagnetic interference (EMI) commonly encountered in two-level converters. Common dc-link MLCs have received particular attention in industry due to their ability to eliminate the need for bulky and inefficient transformers and rectifiers, making them a compelling option for different applications, primarily medium- and high-power/voltage applications such as wind turbine (WT) power conversion systems. Furthermore, common dc-link topologies are required for back-to-back (BTB) configurations, as they facilitate the use of a shared dc-link between the rectification and inversion stages. Despite their popularity, there is currently no comprehensive review article dedicated to common dc-link topologies. This article addresses this gap by presenting a comprehensive review of common dc-link MLCs, covering their topological evolution, features, topologies comparison, modulation techniques, control strategies, and industrial application areas. Additionally, future perspectives and recommendations are discussed to provide researchers and engineers with a better understanding of the potential applications and advantages of these converters., DC systems, Energy conversion & Storage

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the highly variable human leukocyte antigen (HLA) region as the strongest susceptibility locus for IBD and specifically DRB1*01:03 as a determining factor for ulcerative colitis (UC). However, for most of the association signal such as delineation could not be made because of tight structures of linkage disequilibrium within the HLA. The aim of this study was therefore to further characterize the HLA signal using a transethnic approach. We performed a comprehensive fine mapping of single HLA alleles in UC in a cohort of 9272 individuals with African American, East Asian, Puerto Rican, Indian and Iranian descent and 40 691 previously analyzed Caucasians, additionally analyzing whole HLA haplotypes. We computationally characterized the binding of associated HLA alleles to human self-peptides and analyzed the physicochemical properties of the HLA proteins and predicted self-peptidomes. Highlighting alleles of the HLA-DRB1*15 group and their correlated HLA-DQ-DR haplotypes, we not only identified consistent associations (regarding effects directions/magnitudes) across different ethnicities but also identified population-specific signals (regarding differences in allele frequencies). We observed that DRB1*01:03 is mostly present in individuals of Western European descent and hardly present in non-Caucasian individuals. We found peptides predicted to bind to risk HLA alleles to be rich in positively charged amino acids. We conclude that the HLA plays an important role for UC susceptibility across different ethnicities. This research further implicates specific features of peptides that are predicted to bind risk and protective HLA proteins.

This paper used an artificial jellyfish search (AJFS) optimizer suitable for selective harmonic elimination-based modulation for multilevel inverter (MLI) voltage control application. The main objective was to remove the undesired lower-order harmonics in the output voltage waveform of an MLI. This algorithm was motivated by the behavior of jellyfish in the ocean. Jellyfish have the ability to find the global best position where a large quantity of nutritious food is available. The paper applied AJFS algorithm on five, seven, and nine levels of CHB-MLI. The optimum switching angle was calculated for the entire modulation range for the desired lower-order harmonics elimi-nation. The problem formulated to achieve the objective was solved in a MATLAB environment. The total harmonic distortion (THD) values of five-, seven-, and nine-level inverters for various modulation indexes were computed using AJFS and compared with the powerful differential evolution (DE) algorithm. The comparison of THD results clearly demonstrated superior THD in the output of CHB-MLI of the AJFS algorithm over DE and GA algorithm for low and medium values of modulation index. The experimental results further validated the better performance of the AJFS algorithm.

BACKGROUND: The burden of inflammatory bowel disease (IBD) is rising globally, with substantial variation in levels and trends of disease in different countries and regions. Understanding these geographical differences is crucial for formulating effective strategies for preventing and treating IBD. We report the prevalence, mortality, and overall burden of IBD in 195 countries and territories between 1990 and 2017, based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. METHODS: We modelled mortality due to IBD using a standard Cause of Death Ensemble model including data mainly from vital registrations. To estimate the non-fatal burden, we used data presented in primary studies, hospital discharges, and claims data, and used DisMod-MR 2.1, a Bayesian meta-regression tool, to ensure consistency between measures. Mortality, prevalence, years of life lost (YLLs) due to premature death, years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were estimated. All of the estimates were reported as numbers and rates per 100 000 population, with 95% uncertainty intervals (UI). FINDINGS: In 2017, there were 6·8 million (95% UI 6·4-7·3) cases of IBD globally. The age-standardised prevalence rate increased from 79·5 (75·9-83·5) per 100 000 population in 1990 to 84·3 (79·2-89·9) per 100 000 population in 2017. The age-standardised death rate decreased from 0·61 (0·55-0·69) per 100 000 population in 1990 to 0·51 (0·42-0·54) per 100 000 population in 2017. At the GBD regional level, the highest age-standardised prevalence rate in 2017 occurred in high-income North America (422·0 [398·7-446·1] per 100 000) and the lowest age-standardised prevalence rates were observed in the Caribbean (6·7 [6·3-7·2] per 100 000 population). High Socio-demographic Index (SDI) locations had the highest age-standardised prevalence rate, while low SDI regions had the lowest age-standardised prevalence rate. At the national level, the USA ha

The results of the recovery of both aldehyde and ketone carbonyl functionalities from the oxime derivatives in aromatic carbonyl compounds using tetrapyridine silver(II) peroxydisulfate [Ag(py)4S2O 8] as a stable, mild, and efficient oxidizing agent is reported. Yields in excess of 85% were achieved at room temperature in both acetonitrile and aqueous media, making the method versatile and suitable for a wide range of aromatic carbonyl oximes.