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4 results on '"Vagino-cervical microbiome"'

1. Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes

Author

Zhuye Jie, Chen Chen, Lilan Hao, Fei Li, Liju Song, Xiaowei Zhang, Jie Zhu, Liu Tian, Xin Tong, Kaiye Cai, Zhe Zhang, Yanmei Ju, Xinlei Yu, Ying Li, Hongcheng Zhou, Haorong Lu, Xuemei Qiu, Qiang Li, Yunli Liao, Dongsheng Zhou, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Na Liu, Jinghua Wu, Wei Zhang, Xiao Liu, Yang Zong, Weibin Liu, Liang Xiao, Yong Hou, Xun Xu, Huanming Yang, Jian Wang, Karsten Kristiansen, and Huijue Jia

Subjects
Vagino-cervical microbiome, Metagenomic shotgun sequencing, Pregnancy history, Delivery history, Breastfeeding, Biology (General), QH301-705.5, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancy history, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.

Published
2022
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2. Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes

Author

Jie, Zhuye, Chen, Chen, Hao, Lilan, Li, Fei, Song, Liju, Zhang, Xiaowei, Zhu, Jie, Tian, Liu, Tong, Xin, Cai, Kaiye, Zhang, Zhe, Ju, Yanmei, Yu, Xinlei, Li, Ying, Zhou, Hongcheng, Lu, Haorong, Qiu, Xuemei, Li, Qiang, Liao, Yunli, Zhou, Dongsheng, Lian, Heng, Zuo, Yong, Chen, Xiaomin, Rao, Weiqiao, Ren, Yan, Wang, Yuan, Zi, Jin, Wang, Rong, Liu, Na, Wu, Jinghua, Zhang, Wei, Liu, Xiao, Zong, Yang, Liu, Weibin, Xiao, Liang, Hou, Yong, Xu, Xun, Yang, Huanming, Wang, Jian, Kristiansen, Karsten, Jia, Huijue, Jie, Zhuye, Chen, Chen, Hao, Lilan, Li, Fei, Song, Liju, Zhang, Xiaowei, Zhu, Jie, Tian, Liu, Tong, Xin, Cai, Kaiye, Zhang, Zhe, Ju, Yanmei, Yu, Xinlei, Li, Ying, Zhou, Hongcheng, Lu, Haorong, Qiu, Xuemei, Li, Qiang, Liao, Yunli, Zhou, Dongsheng, Lian, Heng, Zuo, Yong, Chen, Xiaomin, Rao, Weiqiao, Ren, Yan, Wang, Yuan, Zi, Jin, Wang, Rong, Liu, Na, Wu, Jinghua, Zhang, Wei, Liu, Xiao, Zong, Yang, Liu, Weibin, Xiao, Liang, Hou, Yong, Xu, Xun, Yang, Huanming, Wang, Jian, Kristiansen, Karsten, and Jia, Huijue

Abstract

The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancy history, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth., The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancy history, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.

Published
2022

3. Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes

Author

Lilan Hao, Dongsheng Zhou, Liju Song, Liang Xiao, Yuan Wang, Heng Lian, Zhe Zhang, Yanmei Ju, Ying Li, Chen Chen, Xin Tong, Na Liu, Qiang Li, Kaiye Cai, Jie Zhu, Yong Hou, Liu Tian, Yan Ren, Fei Li, Karsten Kristiansen, Yong Zuo, Xuemei Qiu, Zhuye Jie, Jinghua Wu, Hongcheng Zhou, Huijue Jia, Xiaomin Chen, Wei Zhang, Xiaowei Zhang, Liao Yunli, Haorong Lu, Jian Wang, Yang Zong, Weibin Liu, Xinlei Yu, Xiao Liu, Jin Zi, Rong Wang, Weiqiao Rao, Huanming Yang, and Xun Xu

Subjects
media_common.quotation_subject, Breastfeeding, Physiology, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Delivery history, Pregnancy history, Pregnancy, RNA, Ribosomal, 16S, Genetics, medicine, Humans, Microbiome, Molecular Biology, Menstrual cycle, 030304 developmental biology, media_common, Vagino-cervical microbiome, 0303 health sciences, Lactobacillus crispatus, biology, Cesarean Section, Microbiota, medicine.disease, biology.organism_classification, Metagenomic shotgun sequencing, Computational Mathematics, Lactobacillus, medicine.anatomical_structure, Metagenomics, Cohort, Vagina, Female, Breast feeding, 030217 neurology & neurosurgery
Abstract

The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancy history, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancy history, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.

Published
2020

4. Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes.

Author

Jie Z, Chen C, Hao L, Li F, Song L, Zhang X, Zhu J, Tian L, Tong X, Cai K, Zhang Z, Ju Y, Yu X, Li Y, Zhou H, Lu H, Qiu X, Li Q, Liao Y, Zhou D, Lian H, Zuo Y, Chen X, Rao W, Ren Y, Wang Y, Zi J, Wang R, Liu N, Wu J, Zhang W, Liu X, Zong Y, Liu W, Xiao L, Hou Y, Xu X, Yang H, Wang J, Kristiansen K, and Jia H

Subjects
Humans, Female, Pregnancy, RNA, Ribosomal, 16S genetics, Vagina microbiology, Lactobacillus genetics, Cesarean Section, Microbiota
Abstract

The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancyhistory, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth., (Copyright © 2022. Published by Elsevier B.V.)

Published
2022
Full Text
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