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The aim of this current research was to investigate airborne fungi in indoor environments at primary schools. The study also examined the correlation between these fungi and building characteristics, as well as some geographical and meteorological parameters. To achieve this aim, a passive sampling method was used. In this study, 148 samples were collected from the indoor environments of 24 schools located in Qom, Iran. To collect the samples, passive sampling was performed using Petri plates containing Sabouraud dextrose agar (SDA). The characteristics of school buildings were evaluated by checklist. The mean ± SD fungal load of indoor air in selected schools was found to be 10.1 ± 14.0 colonies (CFU/dm2 / h). According to the IMA standard, the majority of the classes (71.7%) were in very good condition. The dominant species were as follows: "Aspergillus niger," "Aspergillus candidus," and "Aspergillus flavus." Furthermore, the fungal load of girls' schools was significantly higher than that of the boys' schools (p < 0.05). The correlation analysis using the Pearson test showed that there was a direct correlation between the mean fungal load of classrooms and the number of students (p < 0.01). The highest concentration of fungi was found on the ground floor and in poor ventilation conditions (p < 0.05). During the study, it was found that schools located in the western part of Qom, Iran, had a higher concentration of fungi. This can be attributed to their exposure to the prevailing winds and the penetration of outdoor dusty air into indoor environments. The large number of students in each class and the inappropriate ventilation, which are the causes of airborne culturable fungi of these classes, call for the need for proper operation of school buildings.

A mesoporous MFI zeolite membrane was synthesized using polyacrylamide as a secondary template to separate nickel, chromium, and nitrate ions from water. Various analytical methods were employed to characterize the zeolite powders and membranes. Subsequently, tests were conducted to evaluate water permeation and the rejection of heavy metals and nitrate ions. The incorporation of 0.03 kg kg–1 polyacrylamide resulted in a 90 % mesostructure in the MFI zeolite. Higher amounts of polymer had no positive effect on the mesoporous structure. The membrane demonstrated a high water flux (22 L m–2 h–1) with 99 % nickel and 93 % chromium rejection, and effective nitrate rejection (up to 34 %). Increasing the total dissolved solids from 1 to 1000 µA A–1 led to a 50 % increase in water flux. Additionally, raising the pressure by 2 bar resulted in an 80 % increase in the water flux and 15 % improvement in nitrate rejection.

Abstract Introduction Noncommunicable diseases (NCDs) are the leading cause of morbidity and mortality worldwide, accounting for 74% of deaths annually. Satellite imagery provides previously unattainable data about factors related to NCDs that overcome limitations of traditional, non-satellite-derived environmental data, such as subjectivity and requirements of a smaller geographic area of focus. This systematic literature review determined how satellite imagery has been used to address the top NCDs in the world, including cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes. Methods A literature search was performed using PubMed (including MEDLINE), CINAHL, Web of Science, Science Direct, Green FILE, and Engineering Village for articles published through June 6, 2023. Quantitative, qualitative, and mixed-methods peer-reviewed studies about satellite imagery in the context of the top NCDs (cancer, cardiovascular disease, chronic respiratory disease, and diabetes) were included. Articles were assessed for quality using the criteria from the Oxford Centre for Evidence-Based Medicine. Results A total of 43 studies were included, including 5 prospective comparative cohort trials, 22 retrospective cohort studies, and 16 cross-sectional studies. Country economies of the included studies were 72% high-income, 16% upper-middle-income, 9% lower-middle-income, and 0% low-income. One study was global. 93% of the studies found an association between the satellite data and NCD outcome(s). A variety of methods were used to extract satellite data, with the main methods being using publicly available algorithms (79.1%), preprocessing techniques (34.9%), external resource tools (30.2%) and publicly available models (13.9%). All four NCD types examined appeared in at least 20% of the studies. Conclusion Researchers have demonstrated they can successfully use satellite imagery data to investigate the world’s top NCDs. However, given the rapid increase in satellite technology and artificial intelligence, much of satellite imagery used to address NCDs remains largely untapped. In particular, with most existing studies focusing on high-income countries, future research should use satellite data, to overcome limitations of traditional data, from lower-income countries which have a greater burden of morbidity and mortality from NCDs. Furthermore, creating and refining effective methods to extract and process satellite data may facilitate satellite data’s use among scientists studying NCDs worldwide.

Abstract Background Drug combination therapy is preferred over monotherapy in clinical research to improve therapeutic effects. Developing a new nanodelivery system for cancer drugs can reduce side effects and provide several advantages, including matched pharmacokinetics and potential synergistic activity. This study aimed to examine and determine the efficiency of the gemini surfactants (GSs) as a pH-sensitive polymeric carrier and cell-penetrating agent in cancer cells to achieve dual drug delivery and synergistic effects of curcumin (Cur) combined with tamoxifen citrate (TMX) in the treatment of MCF-7 and MDA-MB-231 human BC cell lines. Methods The synthesized NPs were self-assembled using a modified nanoprecipitation method. The functional groups and crystalline form of the nanoformulation were examined by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and dynamic light scattering (DLS) used to assess zeta potential and particle size, and the morphological analysis determined by transmission electron microscopy (TEM). The anticancer effect was evaluated through an in vitro cytotoxicity MTT assay, flow cytometry analysis, and apoptosis analysis performed for mechanism investigation. Results The tailored NPs were developed with a size of 252.3 ± 24.6 nm and zeta potential of 18.2 ± 4.4 mV capable of crossing the membrane of cancer cells. The drug loading and release efficacy assessment showed that the loading of TMX and Cur were 93.84% ± 1.95% and 90.18% ± 0.56%, respectively. In addition, the drug release was more controlled and slower than the free state. Polymeric nanocarriers improved controlled drug release 72.19 ± 2.72% of Tmx and 55.50 ± 2.86% of Cur were released from the Tmx-Cur-Gs NPs after 72 h at pH = 5.5. This confirms the positive effect of polymeric nanocarriers on the controlled drug release mechanism. moreover, the toxicity test showed that combination-drug delivery was much more greater than single-drug delivery in MCF-7 and MDA-MB-231 cell lines. Cellular imaging showed excellent internalization of TMX-Cur-GS NPs in both MCF-7 and MDA-MB-231 cells and synergistic anticancer effects, with combination indices of 0.561 and 0.353, respectively. Conclusion The combined drug delivery system had a greater toxic effect on cell lines than single-drug delivery. The synergistic effect of TMX and Cur with decreasing inhibitory concentrations could be a more promising system for BC-targeted therapy using GS NPs.

Abstract Directed transportation of materials at molecular scale is important due to its crucial role in the development of nanoelectromechanical devices, particularly the directional movements along the carbon nanotubes (CNTs), due to the applications of CNTs as nano-manipulators, confined reactors, and drug or other materials delivery systems. In the present investigation, we evaluate the movements of C60 fullerenes on the surface of the cone-shaped CNTs. The fullerene molecules indicate directed motion toward the narrower end of CNTs, which is due to the potential energy gradient along the nanotube length. A continuum model is proposed to evaluate the mechanism of the directed motion and the results of the theoretical model are compared with numerical simulations. Directed movements have been examined at various opening angles of CNTs, considering the trajectories of motions, variation of potential energy, and diffusion coefficients. At smaller opening angles, the driving force on the C60 increases and the molecule experiences more directed transport along the nanotube. The motion of fullerene has also been simulated inside the cone-shaped CNTs, with similar opening angle, and different average radius. At lower average radius of the cone-like nanotubes, the motion of C60 is comparatively more rectilinear. Directional transport of fullerene has been observed in the opposite direction, when the molecule moves on the external surface of the cone-like CNTs, which is due to the stronger interaction of C60 with the parts of the external surface with larger radius. The effect of temperature has been evaluated by performing the simulations at the temperature range of 100 to 400 K. The direction of the velocity reveals that the thermal fluctuations at higher temperatures hinder the directed motion of molecule along the cone-shaped CNTs. The results of the present study propose a new method to obtain directed transport of molecules which can be helpful in different applications such as drug delivery systems.

Drawing upon the hermeneutic basis that understanding and interpretation of a text is conditioned by the reader’s preunderstanding, this article examines ʾAllamah Ṭabāṭabāʾī’s interpretive preunderstandings. In so doing, the article first, will explore ʾAllamah’s constitutive and non-constitutive preunderstandings. As the foundation of his Qur'anic interpretation, the constitutive category is divided into three subcategories: text-specific, interpreter-specific, and interpretation-specific. The non-constitutive category is studied under the following two subcategories: the imposed and non-imposed preunderstandings. Although the article studies ʾAllamah Ṭabāṭabāʾī’s interpretive preunderstandings, this categorization can be applied in studying any scriptural hermeneutic discourse. The contribution of this article to the field, is not limited to Allamah Ṭabāṭabāʾī’s interpretive preunderstandings. The method applied in this study can be used in the study of any scriptural hermeneutics.

Understanding the motion of surface-rolling nanomachines has attracted lots of attention in recent studies, due to their ability in carrying molecular payloads and nanomaterials on the surface. Controlling the surface motion of these nanovehicles is beneficial in the fabrication of nano-transportation systems. In the present study, molecular dynamics (MD) simulations alongside the potential energy analysis have been utilized to investigate the motion of C60 and C60-based nanovehicles on the silicene monolayer. Nano-machine simulations are performed using molecular mechanic forcefield. Compared with graphene and hexagonal boron-nitride, the molecules experience a higher energy barrier on the silicene, which leads to a lower diffusion coefficient and higher activation energy of C60 and nanomachines. Overcoming the maximum energy barrier against sliding motion is more probable at higher temperatures where the nanomachines receive higher thermal energy. After evaluating the motion of molecules around local vacancies, we introduce a nanoroad structure that can restrict surface motion. The motion of C60 and nanovehicles over the surface is limited to the width of nanorods up to a certain temperature. To increase the controllability of the motion, a thermal gradient has been applied to the surface and the molecules move toward the lower temperature regions, where they find lower energy levels. Comparing the results of this study with other investigations regarding the surface motion of molecules on boron-nitride and graphene surfaces brings forth the idea of controlling the motion by silicene-based hybrid substrates, which can be further investigated.

Background. Respectful maternity care (RMC) is a crucial approach to enhancing the experiences of mothers. This study aimed to explore women's views on the factors contributing to disrespect and abuse (D and A) during childbirth. Methods. A qualitative study was conducted with 12 postpartum women selected through purposive sampling to ensure maximum diversity. Data were gathered through in-depth semi-structured interviews and analyzed using a conventional content analysis method. Results. The analysis revealed seven key categories. These categories included respect for women, meeting needs and preferences, involvement of women, continuity of care, empathy, adequate human and non-human resources, and factors that deter D and A. Conclusion. It is essential to develop effective interventions to enhance RMC across various dimensions. Providing RMC during and after childbirth necessitates the involvement of policymakers and health managers. This can be accomplished by addressing the welfare and environmental needs, showing empathy towards mothers, safeguarding their privacy, alleviating staff workloads, and transforming the attitudes of healthcare workers.

Abstract There is inconsistent evidence relating to the effects of megestrol acetate (MA) supplementation on cancer patients suffering from anorexia–cachexia syndrome. This review aimed to examine the dose–response effect of MA supplementation in patients with cancer‐associated anorexia/cachexia. Relevant keywords were searched in PubMed, Scopus and ISI Web of Science from inception to June 2023 for randomized controlled trials (RCTs) examining the effect of MA on pathologies in patients with cancer‐associated cachexia. Our primary outcomes were changes in body weight and appetite. However, fatigue and quality of life were secondary outcomes. The mean difference (MD) and 95% confidence interval (95% CI) were estimated using the random‐effects method. Thirteen trials comprising 1229 participants (mean age 60 years) were identified. The results of our highest versus lowest analysis revealed that MA supplementation was not associated with any increase in body weight (MD: 0.64 kg, 95% CI [−0.11, 1.38], P = 0.093, I2 = 69.1%; GRADE = very low certainty). Twelve trials, including 14 effect sizes derived from 1369 patients (intervention = 689, control = 680), provided data on the effect of MA on body weight. Subgroup analyses showed a significant increase in body weight following short‐term intervention (≤8 weeks) and a combination of radiation/chemotherapy as concurrent treatment. A linear dose–response meta‐analysis indicated that each 200 mg/day increment in MA consumption had a significant increase in weight gain (MD: 0.44; 95% CI [0.13, 0.74], P = 0.005; I2 = 97.1%); however, the magnitude of the effect was small. MA administration significantly affected the quality of life based on pooled effect sizes (MD: 1.15, 95% CI [0.76, 1.54], P

Abstract Background and aims Although minimally invasive hysterectomy offers advantages, abdominal hysterectomy remains the predominant surgical method. Creating a standardized dataset and establishing a hysterectomy registry system present opportunities for early interventions in reducing volume and selecting benign hysterectomy methods. This research aims to develop a dataset for designing benign hysterectomy registration system. Methods Between April and September 2020, a qualitative study was carried out to create a data set for enrolling patients who were candidate for hysterectomy. At this stage, the research team conducted an information needs assessment, relevant data element identification, registry software development, and field testing; Subsequently, a web-based application was designed. In June 2023the registry software was evaluated using data extracted from medical records of patients admitted at Al-Zahra Hospital in Tabriz, Iran. Results During two months, 40 patients with benign hysterectomy were successfully registered. The final dataset for the hysterectomy patient registry comprise 11 main groups, 27 subclasses, and a total of 91 Data elements. Mandatory data and essential reports were defined. Furthermore, a web-based registry system designed and evaluated based on data set and various scenarios. Conclusion Creating a hysterectomy registration system is the initial stride toward identifying and registering hysterectomy candidate patients. this system capture information about the procedure techniques, and associated complications. In Iran, this registry can serve as a valuable resource for assessing the quality of care delivered and the distribution of clinical measures.

Abstract Background Insufficient physical activity (PA) is a major risk factor for non-communicable diseases (NCDs) and one of the leading causes of premature mortality worldwide. This study examined the prevalence and independent determinants of insufficient PA among adults resident of Tehran utilizing Tehran Cohort Study Data (TeCS). Method We used the recruitment phase data from the TeCS with complete data on PA. PA was assessed through a Likert-scaled question and categorized into three groups. Utilizing data from the 2016 national census, the age- and sex-weighted prevalence of insufficient PA in Tehran was determined. The adjusted logistic regression model is used to neutralize influencing factors and determine the factors associated with insufficient PA. Result The weighted prevalence of insufficient PA was 16.9% among the 8213 adult citizens of Tehran, with a greater prevalence among females (19.0% vs. 14.8% among males). Additionally, older age groups, unemployed, housewives, and illiterate educated participants displayed a much higher prevalence of insufficient PA (p 30: 1.85, 95% CI: 1.56–2.18, p

Abstract Introduction Several side effects within the patients undergoing hematopoietic stem cell transplantation (HSCT), especially ones that influence nutrition intake, can cause weight loss and malnutrition. Based on studies, oral nutritional supplement (ONS) may reinforce their nutrient intake and progress clinical outcomes. The objective of this research is to investigate the effect of oral nutrition supplements on the nutritional and clinical status of patients undergoing autologous hematopoietic stem cell transplantation. Methods After block randomization used the website www.randomization , 38 patients will be enrolled in this study, patients will be allocated to the intervention (ONS) or control groups in a 1: 1 ratio. Patients in the ONS group will receive 250 ml of standard formula (Ensure®, Abbott Nutrition) which has 14–15% protein twice a day, in the morning and bedtime snacks for 21 days. All the procedures done in the control group will be the same as the ONS group except receiving ONS. We will examine the outcomes include; weight, appetite, hand grip strength, calf circumference, mid-arm circumference, total energy intake, protein intake, carbohydrate intake, fat intake, severity of oral mucositis, rate of infection during hospitalization, graft failure, recurrence rate after transplantation, the number of days it takes for neutrophil and platelet engraftment to occur, number of readmissions after transplantation during three months, mortality rate up to three months after transplantation and the three-day food diary record; all the evaluations will be carried out in three steps; 7 days before transplant, on the 14th day after transplantation, and on the 90th day after the transplantation. Discussion These patients’ weight loss and malnourishment are significant concerns. The use of ONS in patients receiving HSCT has not been the subject of any research. Trial registration This clinical trial was registered in Iranian Registry of Clinical Trials ( http://www.irct.ir ) on 2022-12-09 with the code number IRCT20220208053971N2.

Abstract Rainfed regions have inconsistent spatial and temporal rainfall. So, these regions could face water deficiency during critical stages of crop growth. In this regard, multi-environment trials could play a key role in introducing stable genotypes with good performance across several rainfed regions. Grass pea, as a potential forage crop, is a resilient plant that could grow in unsuitable circumstances. In this study, agro-morphological attributes of 16 grass pea genotypes were examined in four semi-warm rain-fed regions during the years 2018–2021. The MLM analysis of variance showed a significant genotype-by-environment interaction (GEI) for dry yield, seed yield, days to maturity, days to flowering, and plant height of grass pea. The PLS (partial least squares) regression revealed that rainfall in the grass pea establishment stage (October and November) is meaningful. For grass pea cultivation, monthly rainfall during plant growth is important, especially in May, with an aim for seed yield. Regarding dry yield, G5, G10, G11, G12, G13, and G15 were selected as good performers and stable genotypes using DY × WAASB biplots, while SY × WAASB biplot manifested G2, G3, G12, and G13 as superior genotypes with stable seed yield. Considering equal weights for yield as well as the WAASB stability index (50/50), G13 was selected as the best one. Among test environments, E2 and E11 played a prominent role in distinguishing the above genotypes from other ones. In this study, MTSI (multi-trait stability index) analysis was applied to select a stable genotype, considering all measured agro-morphological traits simultaneously. Henceforth, the G5 and G15 grass pea genotypes were discerningly chosen due to their commendable performance in the WAASBY plot. In this context, G13 did not emerge as the winner based on MTSI; however, it exhibited an MTSI value in close proximity to the outer boundary of the circle. Consequently, upon comprehensive consideration of all traits, it is deduced that G5, G13, and G15 can be appraised as promising superior genotypes with stability across diverse environmental conditions.