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1. Reperfusion therapies in patients with acute ischaemic stroke and atrial fibrillation: data on safety and effectiveness from a multi-centre cohort study

Author

Cancelloni, Virginia, Buratti, Mariachiara, Tsivgoulis, Georgios, Furie, Karen L., Tadi, Prasanna, Caso, Valeria, Becattini, Cecilia, Agnelli, Giancarlo, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Alberti, Andrea, Venti, Michele, de Magistris, Ilaria Leone, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria G., Cimini, Ludovica A., Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Sohn, Sung-I. I., Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Sagris, Dimitrios, Adamou, Anastasia, Vadikolias, Kostantinos, Palaiodimou, Lina, Chondrogianni, Maria, Mumoli, Nicola, Galati, Franco, Sacco, Simona, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Mancuso, Michelangelo, Orlandi, Giovanni, Pascarella, Rosario, Tassinari, Tiziana, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Lettieri, Federica, Giuntini, Martina, Lotti, Enrico M., Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Halvatsiotis, Panagiotis, Monaco, Serena, Baronello, Mario M., Csiba, Laszlò, Szabò, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars P., Kepplinger, Jessica, Deleu, Dirk, Gourbali, Vanessa, Yaghi, Shadi, and Paciaroni, Maurizio

Published
2024
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2. Anticoagulation in acute ischemic stroke patients with mechanical heart valves: To bridge or not with heparin. The ESTREM study

Author

Paciaroni, Maurizio, primary, Caso, Valeria, additional, Romoli, Michele, additional, Becattini, Cecilia, additional, Salerno, Alexander, additional, Rapillo, Costanza, additional, Simonnet, Fanny, additional, Strambo, Davide, additional, Canavero, Isabella, additional, Zedde, Marialuisa, additional, Pascarella, Rosario, additional, Sohn, Sung-Il, additional, Sacco, Simona, additional, Ornello, Raffaele, additional, Barlinn, Kristian, additional, Schoene, Daniela, additional, Rahmig, Jan, additional, Mosconi, Maria Giulia, additional, Leone De Magistris, Ilaria, additional, Alberti, Andrea, additional, Venti, Michele, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Padroni, Marina, additional, Laudisi, Michele, additional, Zini, Andrea, additional, Gentile, Luana, additional, Kargiotis, Odysseas, additional, Tsivgoulis, Georgios, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Karapanayiotides, Theodore, additional, Engelter, Stefan T, additional, Polymeris, Alexandros A, additional, Zietz, Annaelle, additional, Bandini, Fabio, additional, Caliandro, Pietro, additional, Reale, Giuseppe, additional, Moci, Marco, additional, Zauli, Aurelia, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Giorli, Elisa, additional, Toni, Danilo, additional, Andrighetti, Marco, additional, Falcou, Anne, additional, Palaiodimou, Lina, additional, Ntaios, George, additional, Sagris, Dimitrios, additional, Karagkiozi, Efstathia, additional, Adamou, Anastasia, additional, Halvatsiotis, Panagiotis, additional, Flomin, Yuriy, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Popovic, Nemanja, additional, Pantoni, Leonardo, additional, Mele, Francesco, additional, Molitierno, Nicola, additional, Lochner, Piergiorgio, additional, Pezzini, Alessandro, additional, Del Sette, Massimo, additional, Sassos, Davide, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Lotti, Enrico Maria, additional, Mastrangelo, Vincenzo, additional, Chiti, Alberto, additional, Naldi, Andrea, additional, Vanacker, Peter, additional, Ferrante, Mario, additional, Volodina, Vera, additional, Mancuso, Michelangelo, additional, Giannini, Nicola, additional, Baldini, Marco, additional, Vadikolias, Kostantinos, additional, Kitmeridou, Sofia, additional, Saggese, Carlo Emanuele, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, and Michel, Patrik, additional

Published
2023
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3. Prestroke CHA2DS2-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study

Author

Acciarresi, Monica, Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Caso, Valeria, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Morotti, Andrea, Costa, Paolo, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H., Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, D'Amore, Cataldo, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Liantinioti, Chrissoula, Corea, Francesco, Del Sette, Massimo, Ageno, Walter, De Lodovici, Maria Luisa, Bono, Giorgio, Baldi, Antonio, D'Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario Maimone, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Mosconi, Maria Giulia, and Lees, Kennedy R.

Published
2017
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4. Anticoagulation in acute ischemic stroke patients with mechanical heart valves: To bridge or not with heparin. The ESTREM study

Author

Paciaroni, Maurizio, Caso, Valeria, Romoli, Michele, Becattini, Cecilia, Salerno, Alexander, Rapillo, Costanza, Simonnet, Fanny, Strambo, Davide, Canavero, Isabella, Zedde, Marialuisa, Pascarella, Rosario, Sohn, Sung-Il, Sacco, Simona, Ornello, Raffaele, Barlinn, Kristian, Schoene, Daniela, Rahmig, Jan, Mosconi, Maria Giulia, Leone De Magistris, Ilaria, Alberti, Andrea, Venti, Michele, Silvestrelli, Giorgio, Ciccone, Alfonso, Padroni, Marina, Laudisi, Michele, Zini, Andrea, Gentile, Luana, Kargiotis, Odysseas, Tsivgoulis, Georgios, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Masotti, Luca, Grifoni, Elisa, Rocco, Alessandro, Diomedi, Marina, Karapanayiotides, Theodore, Engelter, Stefan T, Polymeris, Alexandros A, Zietz, Annaelle, Bandini, Fabio, Caliandro, Pietro, Reale, Giuseppe, Moci, Marco, Zauli, Aurelia, Cappellari, Manuel, Emiliani, Andrea, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Giorli, Elisa, Toni, Danilo, Andrighetti, Marco, Falcou, Anne, Palaiodimou, Lina, Ntaios, George, Sagris, Dimitrios, Karagkiozi, Efstathia, Adamou, Anastasia, Halvatsiotis, Panagiotis, Flomin, Yuriy, Scoditti, Umberto, Genovese, Antonio, Popovic, Nemanja, Pantoni, Leonardo, Mele, Francesco, Molitierno, Nicola, Lochner, Piergiorgio, Pezzini, Alessandro, Del Sette, Massimo, Sassos, Davide, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Lotti, Enrico Maria, Mastrangelo, Vincenzo, Chiti, Alberto, Naldi, Andrea, Vanacker, Peter, Ferrante, Mario, Volodina, Vera, Mancuso, Michelangelo, Giannini, Nicola, Baldini, Marco, Vadikolias, Kostantinos, Kitmeridou, Sofia, Saggese, Carlo Emanuele, Tassinari, Tiziana, Saia, Valentina, and Michel, Patrik

Subjects
Mechanical heart valve, acute stroke, oral anticoagulants, prevention
Published
2023

5. The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Mosconi, Maria Giulia, Giustozzi, Michela, Tsivgoulis, Georgios, Seiffge, David Julian, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna M., Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, De Magistris, Ilaria Leone, Cancelloni, Virginia, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Moci, Marco, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Morotti, Andrea, Magoni, Mauro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Halvatsiotis, Panagiotis, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Baronello, Mario Maimone, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and De Marchis, Gian Marco

Abstract

Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of ischemic and severe bleeding events in ischemic stroke patients having both AF and reduced ejection fraction (rEF) (⩽40%), compared to ischemic stroke patients with AF but without rEF.Methods: We performed a retrospective analysis that drew data from prospective studies. The primary outcome was the composite of either ischemic (stroke or systemic embolism), or hemorrhagic events (symptomatic intracranial bleeding and severe extracranial bleeding).Results: The cohort for this analysis comprised 3477 patients with ischemic stroke and AF, of which, 643 (18.3%) had also rEF. After a mean follow-up of 7.5 ± 9.1 months, 375 (10.8%) patients had 382 recorded outcome events, for an annual rate of 18.0%. While the number of primary outcome events in patients with rEF was 86 (13.4%), compared to 289 (10.2%) for the patients without rEF; on multivariable analysis rEF was not associated with the primary outcome (OR 1.25; 95% CI 0.84–1.88). At the end of follow-up, 321 (49.9%) patients with rEF were deceased or disabled (mRS ⩾3), compared with 1145 (40.4%) of those without rEF; on multivariable analysis, rEF was correlated with mortality or disability (OR 1.35; 95% CI 1.03–1.77).Conclusions: In patients with ischemic stroke and AF, the presence of rEF was not associated with the composite outcome of ischemic or hemorrhagic events over short-term follow-up but was associated with increased mortality or disability.

Published
2023
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6. Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy

Author

Caliandro, Pietro, Cancelloni, Virginia, Marco, Moci, Reale, Giuseppe, Zauli, Aurelia, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Calabresi, Paolo, Giulia Mosconi, Maria, Giustozzi, Michela, Tsivgoulis, Georgios, Julian Seiffge, David, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Marco De Marchis, Gian, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, McTaggart, Ryan, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Maria Lotti, Enrico, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Leone De Magistris, Ilaria, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Emanuele Saggese, Carlo, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Chiara Caselli, Maria, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Halvatsiotis, Panagiotis, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Poli, Loris, Magoni, Mauro, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Girardi, Laura, Maimone Baronello, Mario, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and Paciaroni, Maurizio

Abstract

Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulation therapy (OAC/AP). Our study aims to evaluate the safety and efficacy of OAC/AP therapy as secondary prevention in people with AF and ischaemic stroke.Patients and methods: We performed a post-hoc analysis of pooled individual data from multicenter prospective cohort studies and compared outcomes in the OAC/AP cohort and patients on DOAC/VKA anticoagulation alone (OAC cohort). Primary outcome was a composite of ischaemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischaemic and haemorrhagic events considered separately. A multivariable logistic regression analysis was performed to identify independent predictors for outcome events. To compare the risk of outcome events between the two cohorts, the relation between the survival function and the set of explanatory variables were calculated by Cox proportional hazard models and the results were reported as adjusted hazard ratios (HR). Finally another analysis was performed to compare the overall risk of outcome events in both OAC/AP and OAC cohorts after propensity score matching (PSM).Results: During a mean follow-up time of 7.5 ± 9.1 months (median follow-up time 3.5 months, interquartile range ±3), 2284 stroke patients were on oral anticoagulants and 215 were on combined therapy. The multivariable model demonstrated that the composite outcome is associated with age (OR: 1.03, 95% CI: 1.01–1.04 for each year increase) and concomitant antiplatelet therapy (OR: 2.2, 95% CI: 1.48–3.27), the ischaemic outcome with congestive heart failure (OR: 1.55, 95% CI: 1.02–2.36) and concomitant antiplatelet therapy (OR: 1.93, 95% CI: 1.19–3.13) and the haemorrhagic outcome with age (OR: 1.03, 95% CI: 1.01–1.06 for each year increase), alcoholism (OR: 2.15, 95% CI: 1.06–4.39) and concomitant antiplatelet therapy (OR: 2.22, 95% CI: 1.23–4.02). Cox regression demonstrated a higher rate of the composite outcome (hazard ratio of 1.93 [95% CI, 1.35–2.76]), ischaemic events (HR: 2.05 [95% CI: 1.45–2.87]) and bleeding outcomes (HR: 1.90 [95% CI, 1.06–3.40]) in OAC/AP cohort. After PSM analysis, the composite outcome remained more frequent in people treated with OAC + AP (RR: 1.70 [95% CI, 1.05–2.74]).Discussion: Secondary prevention with combination of oral anticoagulant and antiplatelet therapy after ischaemic stroke was associated with worse outcomes in our cohort.Conclusion: Further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischaemic stroke in patients with atrial fibrillation.

Published
2023
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7. Prognostic value of trans-thoracic echocardiography in patients with acute stroke and atrial fibrillation: findings from the RAF study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Caso, Valeria, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H., Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria Giulia, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Liantinioti, Chrissoula, Corea, Francesco, Del Sette, Massimo, Ageno, Walter, De Lodovici, Maria Luisa, Bono, Giorgio, Baldi, Antonio, D’Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario Maimone, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, and Lees, Kennedy R.

Published
2016
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8. Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema: The ALESSA Score Study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Tsivgoulis, Georgios, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Falocci, Nicola, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria Giulia, Cimini, Ludovica Anna, Procopio, Antonio, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Colombo, Giovanna, Silvestrelli, Giorgio, Ciccone, Alfonso, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, De Lodovici, Maria Luisa, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, D’Anna, Sebastiano, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Lotti, Enrico Maria, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Baronello, Mario Maimone, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Gourbali, Vanessa, and Yaghi, Shadi

Published
2017
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9. Early Recurrence and Cerebral Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Effect of Anticoagulation and Its Timing: The RAF Study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Caso, Valeria, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H., Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Liantinioti, Chrissoula, Corea, Francesco, Del Sette, Massimo, Ageno, Walter, De Lodovici, Maria Luisa, Bono, Giorgio, Baldi, Antonio, D’Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Acciarresi, Monica, D’Amore, Cataldo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario Maimone, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Mosconi, Maria Giulia, Bubba, Valentina, Silvestri, Ilenia, and Lees, Kennedy R.

Published
2015
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10. Early recurrence in paroxysmal versus sustained atrial fibrillation in patients with acute ischaemic stroke

Author

Paciaroni, Maurizio, primary, Angelini, Filippo, additional, Agnelli, Giancarlo, additional, Tsivgoulis, Georgios, additional, Furie, Karen L, additional, Tadi, Prasanna, additional, Becattini, Cecilia, additional, Falocci, Nicola, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil H, additional, Lees, Kennedy R, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, Altavilla, Riccardo, additional, D’Amore, Cataldo, additional, Mosconi, Maria G, additional, Cimini, Ludovica A, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Cappellari, Manuel, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Bandini, Fabio, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Masotti, Luca, additional, Vannucchi, Vieri, additional, Sohn, Sung-Il, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Ntaios, George, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Kostantinos, additional, Vadikolias, Kostantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Mumoli, Nicola, additional, Consoli, Domenico, additional, Galati, Franco, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Orlandi, Giovanni, additional, Giannini, Nicola, additional, Gialdini, Gino, additional, Tassinari, Tiziana, additional, Lodovici, Maria Luisa De, additional, Bono, Giorgio, additional, Rueckert, Christina, additional, Baldi, Antonio, additional, Toni, Danilo, additional, Letteri, Federica, additional, Giuntini, Martina, additional, Lotti, Enrico M, additional, Flomin, Yuriy, additional, Pieroni, Alessio, additional, Kargiotis, Odysseas, additional, Karapanayiotides, Theodore, additional, Monaco, Serena, additional, Baronello, Mario M, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Sette, Massimo Del, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Michel Pd-Mer, Patrik, additional, Vanacker, Peter, additional, Barlinn, Kristian, additional, Pallesen, Lars P, additional, Kepplinger, Jessica, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Gourbali, Vanessa, additional, Yaghi, Shadi, additional, and Caso, Valeria, additional

Published
2018
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11. Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non–Vitamin‐K Oral Anticoagulants (RAF‐NOACs) Study

Author

Paciaroni, Maurizio, primary, Agnelli, Giancarlo, additional, Falocci, Nicola, additional, Tsivgoulis, Georgios, additional, Vadikolias, Kostantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Cappellari, Manuel, additional, Zedde, Marialuisa, additional, Ntaios, George, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Kostantinos, additional, Silvestrelli, Giorgio, additional, Lanari, Alessia, additional, Ciccone, Alfonso, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Abdul‐Rahim, Azmil H., additional, Lees, Kennedy R., additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D'Amore, Cataldo, additional, Becattini, Cecilia, additional, Mosconi, Maria Giulia, additional, Cimini, Ludovica Anna, additional, Soloperto, Rossana, additional, Masotti, Luca, additional, Vannucchi, Vieri, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung‐Il, additional, Marcheselli, Simona, additional, Mumoli, Nicola, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Yaghi, Shadi, additional, Toni, Danilo, additional, Letteri, Federica, additional, Tassinari, Tiziana, additional, Kargiotis, Odysseas, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Giannini, Nicola, additional, Bandini, Fabio, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Consoli, Domenico, additional, Galati, Franco, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Gialdini, Gino, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Monaco, Serena, additional, Maimone Baronello, Mario, additional, Karapanayiotides, Theodore, additional, and Caso, Valeria, additional

Published
2017
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12. Sex-related differences in risk factors, type of treatment received and outcomes in patients with atrial fibrillation and acute stroke: Results from the RAF-study (Early Recurrence and Cerebral Bleeding in Patients with Acute Ischemic Stroke and Atrial Fibrillation)

Author

Antonenko, Kateryna, primary, Paciaroni, Maurizio, additional, Agnelli, Giancarlo, additional, Falocci, Nicola, additional, Becattini, Cecilia, additional, Marcheselli, Simona, additional, Rueckert, Christina, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Sohn, Sung-Il, additional, Tassinari, Tiziana, additional, Abdul-Rahim, Azmil H, additional, Michel, Patrik, additional, Cordier, Maria, additional, Vanacker, Peter, additional, Remillard, Suzette, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D’Amore, Cataldo, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Orlandi, Giovanni, additional, Chiti, Alberto, additional, Gialdini, Gino, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Putaala, Jukka, additional, Tatlisumak, Turgut, additional, Masotti, Luca, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Martini, Giuseppe, additional, Tsivgoulis, Georgios, additional, Vadikolias, Kostantinos, additional, Papageorgiou, Sokratis G, additional, Corea, Francesco, additional, Sette, Massimo Del, additional, Ageno, Walter, additional, Lodovici, Maria Luisa De, additional, Bono, Giorgio, additional, Baldi, Antonio, additional, D’Anna, Sebastiano, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Consoli, Domenico, additional, Galati, Franco, additional, Pieroni, Alessio, additional, Toni, Danilo, additional, Monaco, Serena, additional, Baronello, Mario M, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Kepplinger, Jessica, additional, Bodechtel, Ulf, additional, Gerber, Johannes, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Mosconi, Maria G, additional, Lees, Kennedy R, additional, and Caso, Valeria, additional

Published
2016
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13. Early recurrence in paroxysmal versus sustained atrial fibrillation in patients with acute ischaemic stroke

Author

Paciaroni, Maurizio, Angelini, Filippo, Agnelli, Giancarlo, Tsivgoulis, Georgios, Furie, Karen L, Tadi, Prasanna, Becattini, Cecilia, Falocci, Nicola, Zedde, Marialuisa, Abdul-Rahim, Azmil H, Lees, Kennedy R, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, Altavilla, Riccardo, D’Amore, Cataldo, Mosconi, Maria G, Cimini, Ludovica A, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, Lodovici, Maria Luisa De, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Lotti, Enrico M, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Baronello, Mario M, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Sette, Massimo Del, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel Pd-Mer, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars P, Kepplinger, Jessica, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Gourbali, Vanessa, Yaghi, Shadi, and Caso, Valeria

Abstract

Background The relationship between different patterns of atrial fibrillation and early recurrence after an acute ischaemic stroke is unclear.Purpose In a prospective cohort study, we evaluated the rates of early ischaemic recurrence after an acute ischaemic stroke in patients with paroxysmal atrial fibrillation or sustained atrial fibrillation which included persistent and permanent atrial fibrillation.Methods In patients with acute ischaemic stroke, atrial fibrillation was categorised as paroxysmal atrial fibrillation or sustained atrial fibrillation. Ischaemic recurrences were the composite of ischaemic stroke, transient ischaemic attack and symptomatic systemic embolism occurring within 90 days from acute index stroke.Results A total of 2150 patients (1155 females, 53.7%) were enrolled: 930 (43.3%) had paroxysmal atrial fibrillation and 1220 (56.7%) sustained atrial fibrillation. During the 90-day follow-up, 111 ischaemic recurrences were observed in 107 patients: 31 in patients with paroxysmal atrial fibrillation (3.3%) and 76 with sustained atrial fibrillation (6.2%) (hazard ratio (HR) 1.86 (95% CI 1.24–2.81)). Patients with sustained atrial fibrillation were on average older, more likely to have diabetes mellitus, hypertension, history of stroke/ transient ischaemic attack, congestive heart failure, atrial enlargement, high baseline NIHSS-score and implanted pacemaker. After adjustment by Cox proportional hazard model, sustained atrial fibrillation was not associated with early ischaemic recurrences (adjusted HR 1.23 (95% CI 0.74–2.04)).Conclusions After acute ischaemic stroke, patients with sustained atrial fibrillation had a higher rate of early ischaemic recurrence than patients with paroxysmal atrial fibrillation. After adjustment for relevant risk factors, sustained atrial fibrillation was not associated with a significantly higher risk of recurrence, thus suggesting that the risk profile associated with atrial fibrillation, rather than its pattern, is determinant for recurrence.

Published
2019
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14. Prognostic value of trans-thoracic echocardiography in patients with acute stroke and atrial fibrillation: findings from the RAF study

Author

Paciaroni, Maurizio, primary, Agnelli, Giancarlo, additional, Falocci, Nicola, additional, Caso, Valeria, additional, Becattini, Cecilia, additional, Marcheselli, Simona, additional, Rueckert, Christina, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Sohn, Sung-Il, additional, Tassinari, Tiziana, additional, Abdul-Rahim, Azmil H., additional, Michel, Patrik, additional, Cordier, Maria, additional, Vanacker, Peter, additional, Remillard, Suzette, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D’Amore, Cataldo, additional, Mosconi, Maria Giulia, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Orlandi, Giovanni, additional, Chiti, Alberto, additional, Gialdini, Gino, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Putaala, Jukka, additional, Tatlisumak, Turgut, additional, Masotti, Luca, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Martini, Giuseppe, additional, Tsivgoulis, Georgios, additional, Vadikolias, Kostantinos, additional, Liantinioti, Chrissoula, additional, Corea, Francesco, additional, Del Sette, Massimo, additional, Ageno, Walter, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Baldi, Antonio, additional, D’Anna, Sebastiano, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Consoli, Domenico, additional, Galati, Franco, additional, Pieroni, Alessio, additional, Toni, Danilo, additional, Monaco, Serena, additional, Baronello, Mario Maimone, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Kepplinger, Jessica, additional, Bodechtel, Ulf, additional, Gerber, Johannes, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, and Lees, Kennedy R., additional

Published
2015
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15. Sex-related differences in risk factors, type of treatment received and outcomes in patients with atrial fibrillation and acute stroke: Results from the RAF-study (Early Recurrence and Cerebral Bleeding in Patients with Acute Ischemic Stroke and Atrial Fibrillation)

Author

Antonenko, Kateryna, Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H, Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Papageorgiou, Sokratis G, Corea, Francesco, Sette, Massimo Del, Ageno, Walter, Lodovici, Maria Luisa De, Bono, Giorgio, Baldi, Antonio, D’Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario M, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Mosconi, Maria G, Lees, Kennedy R, and Caso, Valeria

Abstract

Introduction Atrial fibrillation is an independent risk factor of thromboembolism. Women with atrial fibrillation are at a higher overall risk for stroke compared to men with atrial fibrillation. The aim of this study was to evaluate for sex differences in patients with acute stroke and atrial fibrillation, regarding risk factors, treatments received and outcomes.Methods Data were analyzed from the “Recurrence and Cerebral Bleeding in Patients with Acute Ischemic Stroke and Atrial Fibrillation” (RAF-study), a prospective, multicenter, international study including only patients with acute stroke and atrial fibrillation. Patients were followed up for 90 days. Disability was measured by the modified Rankin Scale (0–2 favorable outcome, 3–6 unfavorable outcome).Results Of the 1029 patients enrolled, 561 were women (54.5%) (p< 0.001) and younger (p< 0.001) compared to men. In patients with known atrial fibrillation, women were less likely to receive oral anticoagulants before index stroke (p= 0.026) and were less likely to receive anticoagulants after stroke (71.3% versus 78.4%, p= 0.01). There was no observed sex difference regarding the time of starting anticoagulant therapy between the two groups (6.4 ± 11.7 days for men versus 6.5 ± 12.4 days for women, p= 0.902). Men presented with more severe strokes at onset (mean NIHSS 9.2 ± 6.9 versus 8.1 ± 7.5, p< 0.001). Within 90 days, 46 (8.2%) recurrent ischemic events (stroke/TIA/systemic embolism) and 19 (3.4%) symptomatic cerebral bleedings were found in women compared to 30 (6.4%) and 18 (3.8%) in men (p= 0.28 and p= 0.74). At 90 days, 57.7% of women were disabled or deceased, compared to 41.1% of the men (p< 0.001). Multivariate analysis did not confirm this significance.Conclusions Women with atrial fibrillation were less likely to receive oral anticoagulants prior to and after stroke compared to men with atrial fibrillation, and when stroke occurred, regardless of the fact that in our study women were younger and with less severe stroke, outcomes did not differ between the sexes.

Published
2017
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16. Maximal voluntary ventilation in myasthenia gravis

Author

Heliopoulos, Ioannis, primary, Patlakas, Georgios, additional, Vadikolias, Kostantinos, additional, Artemis, Nicolaos, additional, Kleopa, Kleopas A., additional, Maltezos, Eustratios, additional, and Piperidou, Haritomeni, additional

Published
2003
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