151 results on '"Vachal, Petr"'
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2. Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor
3. Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors.
4. Harnessing the Power of C–H Functionalization Chemistry to Accelerate Drug Discovery
5. Harnessing the Power of C–H Functionalization Chemistry to Accelerate Drug Discovery.
6. Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques
7. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
8. Late-Stage Functionalization for the Optimization of Reversible BTK Inhibitors
9. Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores
10. ORGANIC CHEMISTRY: Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
11. Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties
12. Late-Stage Functionalization for the Optimization of Reversible BTK Inhibitors.
13. Synthesis of HDAC Inhibitor Libraries via Microscale Workflow
14. Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization
15. Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)
16. Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc04751j Click here for additional data file
17. Structure-based analysis and optimization of a highly enantioselective catalyst for the Strecker reaction
18. Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation
19. Profiling and Application of Photoredox C(sp3)–C(sp2) Cross-Coupling in Medicinal Chemistry
20. A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions
21. Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors
22. Correction: The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
23. Selective functionalization of complex heterocycles via an automated strong base screening platform
24. Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents
25. ChemInform Abstract: The Medicinal Chemist′s Toolbox for Late Stage Functionalization of Drug-Like Molecules
26. Chemoselective Peptide Modification via Photocatalytic Tryptophan ß-Position Conjugation.
27. Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach
28. The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
29. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
30. Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis
31. 1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia
32. High-Throughput Purification Platform in Support of Drug Discovery
33. ChemInform Abstract: A General Catalyst for the Asymmetric Strecker Reaction.
34. ChemInform Abstract: Enantioselective Catalytic Addition of HCN to Ketoimines. Catalytic Synthesis of Quaternary Amino Acids.
35. A direct functionalization of tertiary alkyl bromides with O-, N-, and C-nucleophiles
36. 1-Sulfonyl-4-acylpiperazines as Selective Cannabinoid-1 Receptor (CB1R) Inverse Agonists for the Treatment of Obesity
37. A Direct Functionalization of Tertiary Alkyl Bromides with O-, N-, and C-Nucleophiles.
38. Highly Selective and Potent Agonists of Sphingosine-1-phosphate 1 (S1P1) Receptor.
39. Synthesis and Study of Alendronate Derivatives as Potential Prodrugs of Alendronate Sodium for the Treatment of Low Bone Density and Osteoporosis
40. General Facile Synthesis of 2,5-Diarylheteropentalenes.
41. Cyanation of Carbonyl and Imino Groups
42. General facile synthesis of 2,5-diarylheteropentalenes
43. Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptor
44. Structure‐Based Analysis and Optimization of a Highly Enantioselective Catalyst for the Strecker Reaction.
45. Practical Synthesis of a Soluble Schiff Base Catalyst for the Asymmetric Strecker Reaction
46. ChemInform Abstract: A New Approach to the Synthesis of Benzofuro[3,2-b]quinolines, Benzothieno[3,2-b]quinolines and Indolo[3,2-b]quinolines.
47. ChemInform Abstract: Synthesis and Analgesic Activity of Some 1‐Benzofurans, 1‐Benzothiophenes and Indoles.
48. A General Catalyst for the Asymmetric Strecker Reaction
49. Enantioselective Catalytic Addition of HCN to Ketoimines. Catalytic Synthesis of Quaternary Amino Acids
50. Highly Selective and Potent Agonists of Sphingosine-1-phosphate 1 (S1P1) Receptor.
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