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21 results on '"Vaccaro, Daniel"'

1. Virtual Sensor Implementation in Hydroelectric Turbines: A Digital Twin Approach for Clearance Violation Analysis

Author

Marticorena, Matías, Mayer, Rodrigo, Vignolo, Juan, Vaccaro, Daniel, Peyrano, Oscar García, IFToMM, Series Editor, Ceccarelli, Marco, Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Agrawal, Sunil K., Advisory Editor, Ball, Andrew D., editor, Ouyang, Huajiang, editor, Sinha, Jyoti K., editor, and Wang, Zuolu, editor

Published
2024
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2. Dissecting the treatment-naive ecosystem of human melanoma brain metastasis

Author

Biermann, Jana, Melms, Johannes C, Amin, Amit Dipak, Wang, Yiping, Caprio, Lindsay A, Karz, Alcida, Tagore, Somnath, Barrera, Irving, Ibarra-Arellano, Miguel A, Andreatta, Massimo, Fullerton, Benjamin T, Gretarsson, Kristjan H, Sahu, Varun, Mangipudy, Vaibhav S, Nguyen, Trang TT, Nair, Ajay, Rogava, Meri, Ho, Patricia, Koch, Peter D, Banu, Matei, Humala, Nelson, Mahajan, Aayushi, Walsh, Zachary H, Shah, Shivem B, Vaccaro, Daniel H, Caldwell, Blake, Mu, Michael, Wünnemann, Florian, Chazotte, Margot, Berhe, Simon, Luoma, Adrienne M, Driver, Joseph, Ingham, Matthew, Khan, Shaheer A, Rapisuwon, Suthee, Slingluff, Craig L, Eigentler, Thomas, Röcken, Martin, Carvajal, Richard, Atkins, Michael B, Davies, Michael A, Agustinus, Albert, Bakhoum, Samuel F, Azizi, Elham, Siegelin, Markus, Lu, Chao, Carmona, Santiago J, Hibshoosh, Hanina, Ribas, Antoni, Canoll, Peter, Bruce, Jeffrey N, Bi, Wenya Linda, Agrawal, Praveen, Schapiro, Denis, Hernando, Eva, Macosko, Evan Z, Chen, Fei, Schwartz, Gary K, and Izar, Benjamin

Subjects
Cancer, Biotechnology, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Brain Neoplasms, CD8-Positive T-Lymphocytes, Ecosystem, Humans, Melanoma, RNA-Seq, brain metastasis, chromosomal instability, melanoma, neuronal-like cell state, single-cell genomics, spatial transcriptomics, tumor-microenvironment, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant intra-tumoral B to plasma cell differentiation in lymphoid aggregates in MBM. MBM harbored larger fractions of monocyte-derived macrophages and dysfunctional TOX+CD8+ T cells with distinct expression of immune checkpoints. This work provides comprehensive insights into MBM biology and serves as a foundational resource for further discovery and therapeutic exploration.

Published
2022

3. Online Method for Assessment and Tracking of Wear in Kaplan Turbine Runner Blades Operating Mechanism

Author

García Peyrano, Oscar, Vaccaro, Daniel, Mayer, Rodrigo, Marticorena, Matías, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Zhang, Hao, editor, Feng, Guojin, editor, Wang, Hongjun, editor, Gu, Fengshou, editor, and Sinha, Jyoti K., editor

Published
2023
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21. Close your eyes and sleep. Sleep.

Author

Vaccaro, Daniel J.

Subjects
SHORT story (Literary form)
Abstract

The short story "Close Your Eyes and Sleep. Sleep" by Daniel J. Vaccaro is presented.

Published
2008

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