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2. Clinical Impact of Sarcopenia in the Decision-Making Process for Patients with Acute Diverticulitis.

Author

Puccioni, Caterina, Fransvea, Pietro, Rodolfino, Elena, Cintoni, Marco, Vacca, Alessandro, Benedetto, Dario, Mele, Maria Cristina, and Sganga, Gabriele

Subjects
MUSCLE mass, LUMBAR vertebrae, SARCOPENIA, DIVERTICULOSIS, DIVERTICULITIS
Abstract

Background: Acute diverticulitis (AD), an inflammatory complication of diverticulosis, affects around 4% of individuals with diverticulosis, with increased incidence in older populations. This study aims to assess the impact of sarcopenia, the age-related loss of muscle mass, on the clinical decision-making and outcomes of patients with AD. Materials and Methods: A retrospective study was conducted on 237 patients admitted to the Emergency Department (ED) between January 2014 and February 2022. Patients diagnosed with AD Hinchey ≥ 2 via contrasted tomography (CT) were included. Sarcopenia was assessed using CT scans at the third lumbar vertebra (L3), with skeletal muscle area (SMA) normalized by height to calculate the skeletal muscle index (SMI). Patients were divided into two groups based on sarcopenia status and analysed for surgical outcomes, non-operative management (NOM) success, and complications. Results: The prevalence of sarcopenia was 46%. Sarcopenic patients were significantly older and had lower BMI and higher frailty scores. A higher proportion of sarcopenic patients underwent Hartmann, while non-sarcopenic patients more often had anastomosis. Sarcopenia did not significantly affect overall morbidity, mortality, or the failure rate of NOM. However, sarcopenic patients with a BMI > 25 had a higher likelihood of requiring redo surgeries. Conclusions: Sarcopenia plays a critical role in the surgical management of AD but does not predict worse clinical outcomes. The decision to perform surgery, particularly Hartmann's procedure, is influenced by sarcopenia, yet morbidity and mortality rates are comparable between sarcopenic and non-sarcopenic patients. These findings highlight the need for sarcopenia to be considered in preoperative assessments. [ABSTRACT FROM AUTHOR]

Published
2025
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5. Contributors

Author

Alexiou, Athanasios, primary, Amenta, Francesco, additional, Amoroso, Nicola, additional, Andrews, Jessica L., additional, Arba, Francesco, additional, Armato, Ubaldo, additional, Ashraf, Ghulam Md, additional, Attardo, Lapo, additional, Avelino-Silva, Thiago Junqueira, additional, Ayres, Annelise, additional, Bagetta, Giacinto, additional, Balietti, Marta, additional, Battineni, Gopi, additional, Beheshti, Siamak, additional, Belbasis, Lazaros, additional, Bellou, Vanesa, additional, Bergantin, Leandro Bueno, additional, Berríos, Waleska, additional, Boccardi, Virginia, additional, Bosco, Andrea, additional, Briggs, Robert, additional, Burtscher, Johannes, additional, Burtscher, Martin, additional, Caffò, Alessandro O., additional, Cajas-Salazar, Nohelia, additional, Callisaya, Michele L., additional, Caricati-Neto, Afonso, additional, Carlesi, Cecilia, additional, Castillo-Ordoñez, Willian Orlando, additional, Chan, Victor T.T., additional, Chatzichronis, Stylianos, additional, Cheung, Carol Y., additional, Chiarini, Anna M., additional, Cipollini, Virginia, additional, Cipriani, Gabriele, additional, Claeysen, Sylvie, additional, Claffey, Paul, additional, Clarnette, Roger, additional, Corasaniti, Maria Tiziana, additional, Cornelis, Elise, additional, Dal Prà, Ilaria, additional, Darvesh, Sultan, additional, DeBay, Drew R., additional, Del Dotto, Paolo, additional, De Reuck, Jacques, additional, De Vriendt, Patricia, additional, Dharmadasa, Thanuja, additional, Dovey, Kathryn, additional, Downey, H. Fred, additional, Dyer, Adam H., additional, Eccher, Claudio, additional, Endres, Kristina, additional, Evangelou, Evangelos, additional, Fernandez, Francesca, additional, Fong Yan, Alycia, additional, Frith, Emily, additional, Garcez, Flavia Barreto, additional, Giannoni, Patrizia, additional, Giubilei, Franco, additional, Glazachev, Oleg S., additional, Glynn-Servedio, B.E., additional, Golimstok, Angel, additional, Gorus, Ellen, additional, Gottesman, Rebecca F., additional, Hatashita, Shizuo, additional, Holle, Bernhard, additional, Housseini, Mahboobeh, additional, Huynh, William, additional, Ienco, Elena Caldarazzo, additional, Ismeurt, Caroline, additional, Jayakody, Oshadi, additional, Kamalraj, Pabiththa, additional, Wolf-Ostermann, Karin, additional, Kawaguchi, Kazunori, additional, Kennelly, Sean P., additional, Kiernan, Matthew C., additional, King, Anna E., additional, Kitaguchi, Nobuya, additional, Kito, Shinsuke, additional, Laporte Uribe, Franziska, additional, Liu, Yue, additional, Lopez, Antonella, additional, Loprinzi, Paul D., additional, Low, Lee-Fay, additional, Mallet, Robert T., additional, Manukhina, Eugenia B., additional, Marucci, Gabriella, additional, Matias-Guiu, Jordi A., additional, Matthew Wai Kin, Wong, additional, Mecocci, Patrizia, additional, Molloy, D. William, additional, Monteleone, Domenico, additional, Morrone, Luigi Antonio, additional, Moruzzi, Michele, additional, Müller, Thomas, additional, Nady, Braidy, additional, Nunomura, Akihiko, additional, Nuti, Angelo, additional, O'Caoimh, Rónán, additional, O'Halloran, Paul, additional, Padovani, Marina, additional, Pallotta, Graziano, additional, Paolacci, Lucia, additional, Parker, Helen, additional, Perminder Singh, Sachdev, additional, Philippe, Couratier, additional, Poljak, Anne, additional, Raglio, Alfredo, additional, Rainero, Innocenzo, additional, Regan, Bridget, additional, Reid, Larry D., additional, Reinhardt, Sven, additional, René Thyrian, Jochen, additional, Rinnoci, Valentina, additional, Río-Sancho, Sergio del, additional, Rombolà, Laura, additional, Rozenfeld Olchik, Maira, additional, Rubino, Elisa, additional, Sakai, Kazuyoshi, additional, Sakurada, Tsukasa, additional, Sakurada, Shinobu, additional, Savundranayagam, Marie Y., additional, Scorza, Fúlvio Alexandre, additional, Scuteri, Damiana, additional, Serebrovskaya, Tatiana V., additional, Shigeta, Masahiro, additional, Shinagawa, Shunichiro, additional, Spano, Giuseppina, additional, Stuart, Kimberley E., additional, Tagai, Kenji, additional, Tamaoki, Toshio, additional, Taylor, Dylan Z., additional, Traini, Enea, additional, Troili, Fernanda, additional, Vacca, Alessandro, additional, Vickers, James C., additional, Walf, Alicia A., additional, Walker, Keenan A., additional, Wells, Yvonne, additional, Woltjer, Randall J., additional, and Wood, Paul L., additional

Published
2020
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8. Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-González, Pablo, Valero, Sergi, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Smith, A. David, Saenz, Aldo, Bizzarro, Alessandra, Lauria, Alessandra, Vacca, Alessandro, Solomon, Alina, Anastasiou, Anna, Richardson, Anna, Boland, Anne, Koivisto, Anne, Daniele, Antonio, Greco, Antonio, Marianthi, Arnaoutoglou, McGuinness, Bernadette, Fin, Bertrand, Ferrari, Camilla, Custodero, Carlo, Ferrarese, Carlo, Ingino, Carlos, Mangone, Carlos, Reyes Toso, Carlos, Martínez, Carmen, Cuesta, Carolina, Muchnik, Carolina, Joachim, Catharine, Ortiz, Cecilia, Besse, Céline, Johansson, Charlotte, Zoia, Chiara Paola, Laske, Christoph, Anastasiou, Costas, Palacio, Dana Lis, Politis, Daniel G., Janowitz, Daniel, Craig, David, Mann, David M., Neary, David, Jürgen, Deckert, Daian, Delphine, Belezhanska, Diyana, Kohler, Eduardo, Castaño, Eduardo M., Koutsouraki, Effrosyni, Chipi, Elena, De Roeck, Ellen, Costantini, Emanuele, Vardy, Emma R. L. C., Piras, Fabrizio, Roveta, Fausto, Piras, Federica, Prestia, Federico Ariel, Assogna, Francesca, Salani, Francesca, Sala, Gessica, Lacidogna, Giordano, Novack, Gisela, Wilcock, Gordon, Thonberg, Håkan, Kölsch, Heike, Weber, Heike, Boecker, Henning, Etchepareborda, Ignacio, Piaceri, Irene, Tuomilehto, Jaakko, Lindström, Jaana, Laczo, Jan, Johnston, Janet, Deleuze, Jean-François, Harris, Jenny, Schott, Jonathan M., Priller, Josef, Bacha, Juan Ignacio, Snowden, Julie, Lisso, Julieta, Mihova, Kalina Yonkova, Traykov, Latchezar, Morelli, Laura, Brusco, Luis Ignacio, Rainer, Malik, Takalo, Mari, Bjerke, Maria, Del Zompo, Maria, Serpente, Maria, Sanchez Abalos, Mariana, Rios, Mario, Peltonen, Markku, Herrman, Martin J., Kohler, Matias, Rojo, Matias, Jones, Matthew, Orsini, Michela, Medel, Nancy, Olivar, Natividad, Fox, Nick C., Salvadori, Nicola, Hooper, Nigel M., Galeano, Pablo, Solis, Patricia, Bastiani, Patrizia, Passmore, Peter, Heun, Reinhard, Antikainen, Riitta, Olaso, Robert, Perneczky, Robert, Germani, Sandra, López-García, Sara, Love, Seth, Mehrabian, Shima, Bagnoli, Silvia, Kochen, Silvia, Andreoni, Simona, Teipel, Stefan, Todd, Stephen, Pickering-Brown, Stuart, Natunen, Teemu, Tegos, Thomas, Laatikainen, Tiina, Strandberg, Timo, Polvikoski, Tuomo M., Matoska, Vaclav, Ciullo, Valentina, Cores, Valeria, Solfrizzi, Vincenzo, Lisetti, Viviana, Sevillano, Zulma, Abdelnour, C., Aguilera, N., Alarcon, E., Alegret, M., Benaque, A., Boada, M., Buendia, M., Cañabate, P., Carracedo, A., de Rojas, I., Diego, S., Espinosa, A., Gailhajenet, A., García-González, P., Gil, S., Guitart, M., González-Pérez, A., Hernández, I., Ibarria, M., Lafuente, A., Macias, J., Maroñas, O., Martín, E., Martínez, M.T., Marquié, M., Mauleón, A., Montrreal, L., Moreno-Grau, S., Moreno, M., Orellana, A., Ortega, G., Pancho, A., Pelejá, E., Pérez-Cordon, A., Pineda, J.A., Preckler, S., Quintela, I., Real, L.M., Rosende-Roca, M., Ruiz, A., Sáez, M.E., Sanabria, A., Serrano-Rios, M., Sotolongo-Grau, O., Tárraga, L., Valero, S., Vargas, L., Adarmes-Gómez, A.D., Alarcón-Martín, E., Alonso, M.D., Álvarez, I., Álvarez, V., Amer-Ferrer, G., Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Bullido, M.J., Burguera, J.A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M.J., Clarimón, J., Cruz-Gamero, J.M., de Pancorbo, M.M., del Ser, T., Diez-Fairen, M., Escuela, R., Garrote-Espina, L., Fortea, J., Franco-Macías, E., Frank-García, A., Garcia Madrona, S., Gómez-Garre, P., Hevilla, S., Jesús, S., Labrador Espinosa, M.A., Lage, C., Legaz, A., Lleó, A., Lopez de Munain, A., López-García, S., Macias-García, D., Manzanares, S., Marín, M., Marín-Muñoz, J., Marín, T., Martín Montes, A., Martínez, B., Martínez, C., Martínez, V., Martínez-Lage Álvarez, P., Medina, M., Mendioroz Iriarte, M., Menéndez-González, M., Mir, P., Molinuevo, J.L., Pastor, P., Pérez Tur, J., Periñán-Tocino, T., Pineda-Sanchez, R., Piñol-Ripoll, G., Rábano, A., Real de Asúa, D., Rodrigo, S., Rodríguez-Rodríguez, E., Royo, J.L., Sanchez del Valle Díaz, R., Sánchez-Juan, P., Sastre, I., Vicente, M.P., Vigo-Ortega, R., Vivancos, L., Macleod, C., McCracken, C., Brayne, Carol, Bresner, Catherine, Grozeva, Detelina, Bellou, Eftychia, Sommerville, Ewen W., Matthews, F., Leonenko, Ganna, Menzies, Georgina, Windle, Gill, Harwood, Janet, Phillips, Judith, Bennett, K., Luckuck, Lauren, Clare, Linda, Woods, Robert, Saad, Salha, Burholt, Vanessa, Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., Ruiz, Agustín, Smith, A David, Saenz, Aldo, Bizzarro, Alessandra, Lauria, Alessandra, Vacca, Alessandro, Solomon, Alina, Anastasiou, Anna, Richardson, Anna, Boland, Anne, Koivisto, Anne, Daniele, Antonio, Greco, Antonio, Marianthi, Arnaoutoglou, McGuinness, Bernadette, Fin, Bertrand, Ferrari, Camilla, Custodero, Carlo, Ferrarese, Carlo, Ingino, Carlos, Mangone, Carlos, Reyes Toso, Carlos, Martínez, Carmen, Cuesta, Carolina, Muchnik, Carolina, Joachim, Catharine, Ortiz, Cecilia, Besse, Céline, Johansson, Charlotte, Zoia, Chiara Paola, Laske, Christoph, Anastasiou, Costas, Palacio, Dana Lis, Politis, Daniel G, Janowitz, Daniel, Craig, David, Mann, David M, Neary, David, Jürgen, Deckert, Daian, Delphine, Belezhanska, Diyana, Kohler, Eduardo, Castaño, Eduardo M, Koutsouraki, Effrosyni, Chipi, Elena, De Roeck, Ellen, Costantini, Emanuele, Vardy, Emma R L C, Piras, Fabrizio, Roveta, Fausto, Piras, Federica, Prestia, Federico Ariel, Assogna, Francesca, Salani, Francesca, Sala, Gessica, Lacidogna, Giordano, Novack, Gisela, Wilcock, Gordon, Thonberg, Håkan, Kölsch, Heike, Weber, Heike, Boecker, Henning, Etchepareborda, Ignacio, Piaceri, Irene, Tuomilehto, Jaakko, Lindström, Jaana, Laczo, Jan, Johnston, Janet, Deleuze, Jean-François, Harris, Jenny, Schott, Jonathan M, Priller, Josef, Bacha, Juan Ignacio, Snowden, Julie, Lisso, Julieta, Mihova, Kalina Yonkova, Traykov, Latchezar, Morelli, Laura, Brusco, Luis Ignacio, Rainer, Malik, Takalo, Mari, Bjerke, Maria, Del Zompo, Maria, Serpente, Maria, Sanchez Abalos, Mariana, Rios, Mario, Peltonen, Markku, Herrman, Martin J, Kohler, Matias, Rojo, Matias, Jones, Matthew, Orsini, Michela, Medel, Nancy, Olivar, Natividad, Fox, Nick C, Salvadori, Nicola, Hooper, Nigel M, Galeano, Pablo, Solis, Patricia, Bastiani, Patrizia, Passmore, Peter, Heun, Reinhard, Antikainen, Riitta, Olaso, Robert, Perneczky, Robert, Germani, Sandra, López-García, Sara, Love, Seth, Mehrabian, Shima, Bagnoli, Silvia, Kochen, Silvia, Andreoni, Simona, Teipel, Stefan, Todd, Stephen, Pickering-Brown, Stuart, Natunen, Teemu, Tegos, Thomas, Laatikainen, Tiina, Strandberg, Timo, Polvikoski, Tuomo M, Matoska, Vaclav, Ciullo, Valentina, Cores, Valeria, Solfrizzi, Vincenzo, Lisetti, Viviana, Sevillano, Zulma, Abdelnour, C., Aguilera, N., Alarcon, E., Alegret, M., Benaque, A., Boada, M., Buendia, M., Cañabate, P., Carracedo, A., Corbatón-Anchuelo, A., de Rojas, I., Diego, S., Espinosa, A., Gailhajenet, A., García-González, P., Gil, S., Guitart, M., González-Pérez, A., Hernández, I., Ibarria, M., Lafuente, A., Macias, J., Maroñas, O., Martín, E., Martínez, M. T., Marquié, M., Mauleón, A., Montrreal, L., Moreno-Grau, S., Moreno, M., Orellana, A., Ortega, G., Pancho, A., Pelejá, E., Pérez-Cordon, A., Pineda, J. A., Preckler, S., Quintela, I., Real, L. M., Rosende-Roca, M., Ruiz, A., Sáez, M. E., Sanabria, A., Serrano-Rios, M., Sotolongo-Grau, O., Tárraga, L., Valero, S., Vargas, L., Adarmes-Gómez, A. D., Alarcón-Martín, E., Alonso, M. D., Álvarez, I., Álvarez, V., Amer-Ferrer, G., Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Buiza-Rueda, D., Bullido, M. J., Burguera, J. A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M. J., Clarimón, J., Cruz-Gamero, J. M., de Pancorbo, M. M., Del Ser, T., Diez-Fairen, M., Escuela, R., Garrote-Espina, L., Fortea, J., Franco-Macías, E., Frank-García, A., García-Alberca, J. M., Garcia Madrona, S., Garcia-Ribas, G., Gómez-Garre, P., Hevilla, S., Jesús, S., Labrador Espinosa, M. A., Lage, C., Legaz, A., Lleó, A., Lopez de Munain, A., López-García, S., Macias-García, D., Manzanares, S., Marín, M., Marín-Muñoz, J., Marín, T., Martín Montes, A., Martínez, B., Martínez, C., Martínez, V., Martínez-Lage Álvarez, P., Medina, M., Mendioroz Iriarte, M., Menéndez-González, M., Mir, P., Molinuevo, J. L., Pastor, P., Pérez Tur, J., Periñán-Tocino, T., Pineda-Sanchez, R., Piñol-Ripoll, G., Rábano, A., Real de Asúa, D., Rodrigo, S., Rodríguez-Rodríguez, E., Royo, J. L., Sanchez Del Valle Díaz, R., Sánchez-Juan, P., Sastre, I., Vicente, M. P., Vigo-Ortega, R., Vivancos, L., Macleod, C., McCracken, C., Brayne, Carol, Bresner, Catherine, Grozeva, Detelina, Bellou, Eftychia, Sommerville, Ewen W, Matthews, F., Leonenko, Ganna, Menzies, Georgina, Windle, Gill, Harwood, Janet, Phillips, Judith, Bennett, K., Luckuck, Lauren, Clare, Linda, Woods, Robert, Saad, Salha, Burholt, Vanessa, Rongve, Arvid, Brussels Heritage Lab, Clinical sciences, Neuroprotection & Neuromodulation, and Neurology

Subjects
polygenic risk scores, Multidisciplinary, Common variants, Neuroscience(all), neurology, Medizin, General Physics and Astronomy, ddc:500, General Chemistry, Alzheimer's disease, General Biochemistry, Genetics and Molecular Biology, RISK STRATIFICATION
Abstract

The original version of this Article omitted from the author list the 212th author Patrizia Mecocci, who is from the Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. Consequently, the “Sample Contribution” section of Author Contributions was updated to add “P.M” between “P.D.” and “R.C.”. Additionally, the original version of this Article contained the incorrect affiliation for author Patrick Gavin Kehoe, which incorrectly read “German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany”. The correct version replaces this affiliation with “Bristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK”. This has been corrected in both the PDF and HTML versions of the Article. CA extern

Published
2023
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9. Busulfan or Treosulfan Conditioning Platform for Allogeneic Stem Cell Transplantation in Patients Aged >60 y with Acute Myeloid Leukemia/Myelodysplastic Syndrome: A Subanalysis of the GITMO AlloEld Study

Author

Malagola, M., Polverelli, N., Martino, Michelangelo, Patriarca, Fabrizio, Bruno, Brunella, Giaccone, L., Grillo, G., Bramanti, S., Bernasconi, P., De Gobbi, M., Natale, A., Terruzzi, E., Olivieri, Alessandra, Chiusolo, Patrizia, Carella, A. M., Casini, Marina, Maffini, E., Nozzoli, C., Mazza, P., Bassi, S., Onida, F., Vacca, Alessandro, Falcioni, S., Luppi, M., Iori, A. P., Pavone, V., Skert, C., Carluccio, P., Borghero, C., Proia, A., Selleri, C., Rubini, V., Sacchi, N., Oldani, E., Bonifazi, F., Ciceri, F., Russo, Daniele, Bernardi, S., Farina, M., Fiore, M., Lupo Stanghellini, M. T., Fanin, R., Faraci, D. G., Castagna, Luigi, Colombo, A. A., Nicoli, P., Santarone, S., Scortechini, I., Metafuni, Elisabetta, Merla, E., Cavattoni, I., Cutini, I., Mazzone, A., Saporiti, G., Canale, F. A., Piras, Edoardo, Galieni, P., Debbia, G., La Rocca, U., Mele, Dario Antonio, Carobolante, F., Elice, F., Fanelli, F., Martino M., Patriarca F., Bruno B., Olivieri A., Chiusolo P. (ORCID:0000-0002-1355-1587), Casini M. (ORCID:0000-0002-3209-7770), Vacca A., Russo D., Castagna L., Metafuni E., Piras E., Mele A., Malagola, M., Polverelli, N., Martino, Michelangelo, Patriarca, Fabrizio, Bruno, Brunella, Giaccone, L., Grillo, G., Bramanti, S., Bernasconi, P., De Gobbi, M., Natale, A., Terruzzi, E., Olivieri, Alessandra, Chiusolo, Patrizia, Carella, A. M., Casini, Marina, Maffini, E., Nozzoli, C., Mazza, P., Bassi, S., Onida, F., Vacca, Alessandro, Falcioni, S., Luppi, M., Iori, A. P., Pavone, V., Skert, C., Carluccio, P., Borghero, C., Proia, A., Selleri, C., Rubini, V., Sacchi, N., Oldani, E., Bonifazi, F., Ciceri, F., Russo, Daniele, Bernardi, S., Farina, M., Fiore, M., Lupo Stanghellini, M. T., Fanin, R., Faraci, D. G., Castagna, Luigi, Colombo, A. A., Nicoli, P., Santarone, S., Scortechini, I., Metafuni, Elisabetta, Merla, E., Cavattoni, I., Cutini, I., Mazzone, A., Saporiti, G., Canale, F. A., Piras, Edoardo, Galieni, P., Debbia, G., La Rocca, U., Mele, Dario Antonio, Carobolante, F., Elice, F., Fanelli, F., Martino M., Patriarca F., Bruno B., Olivieri A., Chiusolo P. (ORCID:0000-0002-1355-1587), Casini M. (ORCID:0000-0002-3209-7770), Vacca A., Russo D., Castagna L., Metafuni E., Piras E., and Mele A.

Abstract

Background. The conditioning regimens with different alkylators at different doses can influence the outcome of allogeneic stem cell transplantation (SCT), but conclusive data are missing. Methods. With the aim to analyze real-life allogeneic SCTs performed in Italy between 2006 and 2017 in elderly patients (aged >60 y) with acute myeloid leukemia or myelodysplastic syndrome, we collected 780 first transplants data. For analysis purposes, patients were grouped according to the type of alkylator included in the conditioning (busulfan [BU]-based; n = 618; 79%; treosulfan [TREO]-based; n=162; 21%). Results. No significant differences were observed in nonrelapse mortality, cumulative incidence of relapse, and overall survival, although in the TREO-based group, we observed a greater proportion of elderly patients (P < 0.001); more active diseases at the time of SCT (P < 0.001); a higher prevalence of patients with either hematopoietic cell transplantation-comorbidity index ≥3 (P < 0.001) or a good Karnofsky performance status (P = 0.025); increased use of peripheral blood stem cells as graft sources (P < 0.001); and greater use of reduced intensity conditioning regimens (P = 0.013) and of haploidentical donors (P < 0.001). Moreover, the 2-y cumulative incidence of relapse with myeloablative doses of BU was significantly lower than that registered with reduced intensity conditioning (21% versus 31%; P = 0.0003). This was not observed in the TREO-based group. Conclusions. Despite a higher number of risk factors in the TREO group, no significant differences were observed in nonrelapse mortality, cumulative incidence of relapse, and overall survival according to the type of alkylator, suggesting that TREO has no advantage over BU in terms of efficacy and toxicity in acute myeloid leukemia and myelodysplastic syndrome.

Published
2023

23. Acute Clinical Impact of COVID-19 Quarantine on Patients with Alzheimer's Disease and Other Dementias: An Observational Study

Author

Rainero, Innocenzo, primary, Bruni, Amalia C., additional, Marra, Camillo, additional, Cagnin, Annachiara, additional, Bonanni, Laura, additional, Cupidi, Chiara, additional, Laganà, Valentina, additional, Rubino, Elisa, additional, Vacca, Alessandro, additional, Di Lorenzo, Raffaele, additional, Provero, Paolo, additional, Isella, Valeria, additional, Vanacore, Nicola, additional, Agosta, Federica, additional, Appollonio, Ildebrando, additional, Caffarra, Paolo, additional, Bussè, Cinzia, additional, Sambati, Renato, additional, Quaranta, Davide, additional, Guglielmi, Valeria, additional, Logroscino, Giancarlo, additional, Filippi, Massimo, additional, Tedeschi, Gioacchino, additional, and Ferrarese, Carlo, additional

Published
2020
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26. Response to a letter to the editor

Author

Rubino, Elisa, primary, Zhang, Ming, additional, Mongini, Tiziana, additional, Boschi, Silvia, additional, Vercelli, Liliana, additional, Vacca, Alessandro, additional, Govone, Flora, additional, Gai, Annalisa, additional, Giordana, Maria Teresa, additional, Grinberg, Mark, additional, Rogaeva, Ekaterina, additional, and Rainero, Innocenzo, additional

Published
2019
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27. Consistent effects of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: Additional findings from the randomized, sham-controlled, double-blind PRESTO trial 11 Medical and Health Sciences 1103 Clinical Sciences

Author

Martelletti, Paolo, Barbanti, Piero, Grazzi, Licia, Pierangeli, Giulia, Rainero, Innocenzo, Geppetti, Pierangelo, Ambrosini, Anna, Sarchielli, Paola, Tassorelli, Cristina, Liebler, Eric, De Tommaso, Marina, Bitetto, Vito, De Icco, Roberto, Martinelli, Daniele, Sances, Grazia, Bianchi, Monica, Padovan, Anna Maria, Ricci, Katia Ivana, Vecchio, Eleonora, Cortelli, Pietro, Cevoli, Sabina, Terlizzi, Rossana, Negro, Andrea, Chiariello, Gabriella Addolorata, De Martino, Paola, Gai, Annalisa, Govone, Flora, Masuzzo, Federica, Rubino, Elisa, Torrieri, MARIA CLAUDIA, Vacca, Alessandro, Chiarugi, Alberto, De Cesaris, Francesco, Puma, Simone Li, Lupi, Chiara, Marone, Ilaria, Perrotta, Armando, Corbelli, Ilenia, Romoli, Michele, Simoni, Simone, Verzina, Angela, Aurilia, Cinzia, Egeo, Gabriella, Fofi, Luisa, Andersson, Annelie, Spitzer, Lia, Marin, Juana, Mcclure, Candace, Thackeray, Lisa, Baldi, Maria Giovanna, and Di Maro, Daniela

Subjects
Adult, Male, Analgesics, Adolescent, Vagus Nerve Stimulation, Neuromodulation, Migraine Disorders, Double-blind, Pain intensity, Middle Aged, Young Adult, Treatment Outcome, Anesthesiology and Pain Medicine, Double-Blind Method, Italy, Humans, Pain Management, Open-label, Female, Migraine, Vagus nerve stimulation, Aged, Neurology (clinical)
Published
2018

28. ATXN2 intermediate repeat expansions influence the clinical phenotype in frontotemporal dementia

Author

Rubino, Elisa, primary, Mancini, Cecilia, additional, Boschi, Silvia, additional, Ferrero, Patrizia, additional, Ferrone, Marina, additional, Bianca, Stefano, additional, Zucca, Milena, additional, Orsi, Laura, additional, Pinessi, Lorenzo, additional, Govone, Flora, additional, Vacca, Alessandro, additional, Gai, Annalisa, additional, Giordana, Maria Teresa, additional, Brusco, Alfredo, additional, and Rainero, Innocenzo, additional

Published
2019
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29. The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey.

Author

Rainero, Innocenzo, Bruni, Amalia C., Marra, Camillo, Cagnin, Annachiara, Bonanni, Laura, Cupidi, Chiara, Laganà, Valentina, Rubino, Elisa, Vacca, Alessandro, Di Lorenzo, Raffaele, Provero, Paolo, Isella, Valeria, Vanacore, Nicola, Agosta, Federica, Appollonio, Ildebrando, Caffarra, Paolo, Bussè, Cinzia, Sambati, Renato, Quaranta, Davide, and Guglielmi, Valeria

Subjects
CAREGIVERS, DEMENTIA patients, COVID-19, LEWY body dementia, PATIENTS' families, FRONTOTEMPORAL lobar degeneration, VASCULAR dementia
Abstract

Introduction: Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer's disease and other dementias, and evaluated caregivers' distress during COVID-19 quarantine. Methods: The study involved 87 Italian Dementia Centers. Patients with Alzheimer's Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after quarantine declaration. Main outcomes were patients' changes in cognitive, behavioral, and motor symptoms. Secondary outcomes were effects on caregivers' psychological features. Results: 4913 patients (2934 females, 1979 males) fulfilled the inclusion criteria. Caregivers reported a worsening in cognitive functions in 55.1% of patients, mainly in subjects with DLB and AD. Aggravation of behavioral symptoms was observed in 51.9% of patients. In logistic regression analysis, previous physical independence was associated with both cognitive and behavioral worsening (odds ratio 1.85 [95% CI 1.42–2.39], 1.84 [95% CI 1.43–2.38], respectively). On the contrary, pandemic awareness was a protective factor for the worsening of cognitive and behavioral symptoms (odds ratio 0.74 [95% CI 0.65–0.85]; and 0.72 [95% CI 0.63–0.82], respectively). Approximately 25.9% of patients showed the onset of new behavioral symptoms. A worsening in motor function was reported by 36.7% of patients. Finally, caregivers reported a high increase in anxiety, depression, and distress. Conclusion: Our study shows that quarantine for COVID-19 is associated with an acute worsening of clinical symptoms in patients with dementia as well as increase of caregivers' burden. Our findings emphasize the importance to implement new strategies to mitigate the effects of quarantine in patients with dementia. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia.

Author

Cagnin, Annachiara, Di Lorenzo, Raffaele, Marra, Camillo, Bonanni, Laura, Cupidi, Chiara, Laganà, Valentina, Rubino, Elisa, Vacca, Alessandro, Provero, Paolo, Isella, Valeria, Vanacore, Nicola, Agosta, Federica, Appollonio, Ildebrando, Caffarra, Paolo, Pettenuzzo, Ilaria, Sambati, Renato, Quaranta, Davide, Guglielmi, Valeria, Logroscino, Giancarlo, and Filippi, Massimo

Subjects
COVID-19, DEMENTIA patients, IRRITABILITY (Psychology), LEWY body dementia, BURDEN of care, APATHY
Abstract

Background: In March 2020, the World Health Organization declared a global pandemic due to the novel coronavirus SARS-CoV-2 and several governments planned a national quarantine in order to control the virus spread. Acute psychological effects of quarantine in frail elderly subjects with special needs, such as patients with dementia, have been poorly investigated. The aim of this study was to assess modifications of neuropsychiatric symptoms during quarantine in patients with dementia and their caregivers. Methods: This is a sub-study of a multicenter nation-wide survey. A structured telephone interview was delivered to family caregivers of patients with diagnosis of Alzheimer disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and vascular dementia (VD), followed regularly at 87 Italian memory clinics. Variations in behavioral and psychological symptoms (BPSD) were collected after 1 month since quarantine declaration and associations with disease type, severity, gender, and caregiver's stress burden were analyzed. Results: A total of 4,913 caregivers participated in the survey. Increased BPSD was reported in 59.6% of patients as worsening of preexisting symptoms (51.9%) or as new onset (26%), and requested drug modifications in 27.6% of these cases. Irritability, apathy, agitation, and anxiety were the most frequently reported worsening symptoms and sleep disorder and irritability the most frequent new symptoms. Profile of BPSD varied according to dementia type, disease severity, and patients' gender. Anxiety and depression were associated with a diagnosis of AD (OR 1.35, CI: 1.12–1.62), mild to moderate disease severity and female gender. DLB was significantly associated with a higher risk of worsening hallucinations (OR 5.29, CI 3.66–7.64) and sleep disorder (OR 1.69, CI 1.25–2.29), FTD with wandering (OR 1.62, CI 1.12–2.35), and change of appetite (OR 1.52, CI 1.03–2.25). Stress-related symptoms were experienced by two-thirds of caregivers and were associated with increased patients' neuropsychiatric burden (p<0.0001). Conclusion: Quarantine induces a rapid increase of BPSD in approximately 60% of patients and stress-related symptoms in two-thirds of caregivers. Health services need to plan a post-pandemic strategy in order to address these emerging needs. [ABSTRACT FROM AUTHOR]

Published
2020
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31. High Risk of Suicide in Behavioral Variant Frontotemporal Dementia

Author

Zucca, Milena, primary, Rubino, Elisa, additional, Vacca, Alessandro, additional, Govone, Flora, additional, Gai, Annalisa, additional, De Martino, Paola, additional, Boschi, Silvia, additional, Gentile, Salvatore, additional, Giordana, Maria Teresa, additional, and Rainero, Innocenzo, additional

Published
2018
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35. Subclinical hypothyroidism is associated with migraine: A case-control study

Author

Rubino, Elisa, primary, Rainero, Innocenzo, additional, Garino, Francesca, additional, Vicentini, Costanza, additional, Govone, Flora, additional, Vacca, Alessandro, additional, Gai, Annalisa, additional, Gentile, Salvatore, additional, Govone, Guido, additional, Ragazzoni, Federico, additional, Pinessi, Lorenzo, additional, Giordana, Maria Teresa, additional, and Limone, Paolo, additional

Published
2018
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39. Analisi comportamentale della scelta del percorso attraverso l'utilizzo di nuove tecnologie di acquisizione delle informazioni

Author

Vacca, Alessandro

Subjects
ICAR/05 Trasporti
Abstract

In travel demand modeling, route choice is one of the most complex decision-making contexts to understand and mathematically represent for several reasons. Firstly, a large number of available paths may exist between the same origin-destination (OD) pair. Secondly, neither the traveler nor the modeler are aware of all the available alternatives. Thirdly, individual choices are dictated by different constraints and preferences that are difficult to capture by modelers who face increasingly larger datasets where retrieving the exact path chosen by travelers is not always straightforward. Last, there is a lot of uncertainty about travelers’ perceptions of route characteristics as well as other characteristics that can influence their choices, such as age, gender, habit, weather conditions and network conditions. This highlights the difficulties encountered for interpreting individual user behavior in greater depth. The rapid advances in GPS devices, has resulted in major benefits for data collection, which now can be recorded automatically and with greater accuracy compared to the techniques used in the past (phone calls, e-mails, face-to-face interviews, laboratory experiments.). On these basis the main objective of the thesis is then to study route choice using a GPS database. The data were acquired during a survey, named "Casteddu Mobility Styles” (CMS), conducted by the University of Cagliari (Italy) in the metropolitan area of Cagliari between February 2011 and June 2012. Each participant was asked to carry a smartphone with builtin GPS in which an application called “Activity Locator” – implemented by CRiMM (Centre for Research on Mobility and Modeling) – had been installed. A total of 8831 trips were recorded by 109 individuals, of which 4791 referring to the car driver mode. Each GPS track (consisting of a sequence of referenced position points) was then treated with map-matching techniques, through which it was possible to associate each “GPS point” to a link of the network, thus creating the observed route database. The first objective of the thesis is to understand which are the characteristics of the data acquired during the CMS survey, doing firstly the same analysis that other authors did in their researches based on GPS data. In almost all the previous researches, the GPS data were collected through in-vehicle surveys that make it possible to gather objective information on trips (travel times and distances). Pre-and post-analysis interviews were conducted to gather information about the subjective characteristics of the individuals and GIS platforms were used to study the routes. In the present study, the data were collected using an integrated system able to also record the activities conducted, along with all the characteristics associated thereto. In this way a complete database was created containing all the information (objective and not) concerning the trips. For comparisons with the objectively most convenient paths, then, was used a static macrosimulation model (implemented in CUBE, Citilabs Ltd.) of the entire study area (Cagliari and its metropolitan area), which reproduces the network characteristics actually encountered by the drivers referring to the data used. From this first analysis it was observed that when more than one route is taken for repetitive trips between the same OD. In order to understand these particular behavior of users, named also intravariability, discrete choice models were estimated. It’s important to note that in the previous GPS-based researches this particular behavior was only identified, without studying it in depth. Several other studies, focused on route switching behavior, tried to understand it applying discrete choice models, but their database were based on data acquired through questionnaires or laboratory experiments, and for the majority the route switching behavior was studied in relation to the trip information provision. The objective of this analysis is then to combine the two fields of the research on route switching, trying to understand it estimating discrete choice models using a GPS based database, closing the gap of the previous researches. The final goal of the model estimations is to understand which are the main attributes of the routes and the characteristics of the users that most influence the choice of an habitual route for the same origin-destination (OD) trip. After these first analysis, the final objective of the thesis is to apply a route choice model to GPS-based data. Modeling route choice behavior is generally framed as a two-stage process: generation of the alternative routes and modeling of the choice from the generated choice set. The focus of this step of the research is on the bias that might be introduced in the model estimation by the choice set generation process. Specifically, although several explicit choice set generation techniques are found in the literature, the focus is on stochastic route generation and the correction for unequal sampling probability of routes when applying this technique that is easily applicable to large-scale networks. Indeed, stochastic route generation is a case of importance sampling where the selection of the path depends on its own properties, so route choice models based on stochastic route generation must include a sampling correction coefficient that accounts for the different selection probability. In this study is proposed a methodology for calculating and considering this correction factor into MNL-based models with choice sets generated by means of stochastic route generation. Specifically, was decided to look at the sampling correction factor proposed for the random walk algorithm and to calculate the route selection probability in order to exploit this expression. Therefore, a procedure is proposed for the computation of the selection probabilities on the basis of the stochastic generation principle, then the correction factor and last the EPS for model estimation. The modeling analysis confirms the functionality of the proposed approach that has great advantages: (i) it provides insight into the application of stochastic generation in route choice modeling, especially in large-scale networks where the only need is a standard random number generator and a Dijkstra algorithm; it proposes a simple and manageable procedure from the computational perspective for the calculation of route selection probabilities and hence the correction factor and EPS for model estimation; it proves the efficiency of the proposed methodology on revealed preference data in a dense urban network by showing an increase in goodness-of-fit of the model and a shift from illogical to logical sign in parameters estimated for key variables such as travel time.

Published
2015

40. High Risk of Suicide in Behavioral Variant Frontotemporal Dementia.

Author

Zucca, Milena, Rubino, Elisa, Vacca, Alessandro, Govone, Flora, Gai, Annalisa, De Martino, Paola, Boschi, Silvia, Gentile, Salvatore, Giordana, Maria Teresa, and Rainero, Innocenzo

Abstract

Aim: The purpose of the study was to determine the prevalence of suicidal ideation and attempts in patients with behavioral variant frontotemporal dementia (bvFTD), evaluating possible risk factors for suicidality. Methods: Risk of suicide was assessed using the Scale for Suicide Ideation (SSI) in 35 patients with bvFTD and 25 controls. Results: According to SSI, 40% of patients with bvFTD had suicidal ideation in comparison to 8% of controls (P =.009). Four patients with bvFTD have attempted suicide versus none control (P =.006). Patients with bvFTD with suicide risk showed higher levels of anxiety, depression, stress, and hopelessness than patients without suicide risk (P <.001). Patients who attempted suicide were younger and had a longer disease duration than those with only suicide ideation. Intriguingly, 40% of patients with parkinsonism presented high level of suicide ideation. Conclusions: Our findings show that patients with bvFTD have a high risk of suicide. Additional studies in larger populations are needed to confirm our results. [ABSTRACT FROM AUTHOR]

Published
2019
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42. L'autotrasporto di cose per conto di terzi: Profili tariffari e prospettive di sviluppo

Author

Vacca, Alessandro

Subjects
IUS/06 Diritto della navigazione
Abstract

Il presente elaborato concerne le problematiche giuridiche connesse alla regolamentazione del settore dell’autotrasporto di cose per conto di terzi in Italia, con particolare attenzione alla disciplina dei profili tariffari ed alle dinamiche consolidatesi nella prassi in relazione alle pratiche di dumping sociale, outsourcing e delocalizzazione. Nella prima parte, dopo una premessa finalizzata a descrivere le caratteristiche strutturali dei fornitori di servizi di autotrasporto in ambito nazionale e comunitario nonchè le principali peculiarità del mercato di riferimento, viene descritta ed analizzata l’evoluzione normativa e giurisprudenziale verificatasi con riguardo ai profili tariffari dell’autotrasporto, esaminando in particolare le caratteristiche ed i profili di criticità propri delle discipline in materia di “tariffe a forcella” di cui alla L. n. 298/1974 e di “costi minimi di sicurezza” di cui all’art. 83-bis del D.L. n. 112/2008, fino a giungere all’analisi degli scenari conseguenti alla recente riforma del settore apportata dalla Legge di Stabilità 2015 (L. 23/12/2014, n. 190). Nella seconda parte, vengono esaminate alcune tematiche problematiche che interessano il settore, sia a livello nazionale che comunitario, e che risultano strettamente connesse ai sopra menzionati profili tariffari. In particolare, si fa riferimento alle fattispecie del cabotaggio stradale, del distacco transazionale di lavoratori e dell’abuso della libertà di stabilimento in ambito comunitario concretantesi nella fattispecie della esterovestizione. Tali problematiche sono state analizzate dapprima attraverso la ricostruzione del quadro normativo nazionale e comunitario di riferimento; in secondo luogo, attraverso l’esame dei profili critici emersi alla luce delle dinamiche di mercato invalse nel settore e, infine, in relazione all’analisi dello scenario futuro desumibile dalle iniziative legislative ed amministrative in atto, nonché dagli indirizzi interpretativi affermatisi in ambito giurisprudenziale., The research is focused on the analysis of the regulation of road haulage in Italy, with particular regard to issues related to tariffs and to the practices of social dumping, outsourcing and business relocation. In the first part, further to the description of the main characteristics of Italian and EU suppliers of road haulage services, it is described and analyzed the evolution of regulation and jurisprudence regarding road haulage tariffs aspects, with particular regard to the provisions set forth in Law no. 298 of 1974, Law Decree no. 112 of 2008 and Law no. 190 of 2014. The second part is focused on the analysis of some problematical issues regarding road haulage both at national and EU level, and in particular road cabotage, posting of workers and abuse of freedom of establishment within EU in the road haulage sector

Published
2015
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43. Investigating the role of adipokines in chronic migraine

Author

Rubino, Elisa, primary, Vacca, Alessandro, additional, Govone, Flora, additional, Gai, Annalisa, additional, Boschi, Silvia, additional, Zucca, Milena, additional, De Martino, Paola, additional, Gentile, Salvatore, additional, Pinessi, Lorenzo, additional, and Rainero, Innocenzo, additional

Published
2016
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