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5. The association of obesogenic environments with weight status, blood pressure, and blood lipids: A cross-sectional pooled analysis across five cohorts

Author

T Schram, Miranda, Dagnelie, Pieter C., van Greevenbroek, Marleen MJ., Stehouwer, Coen DA., van der Kallen, Carla J., Meijer, Paul, Lam, Thao Minh, Vaartjes, Ilonca, Moll van Charante, Eric, Galenkamp, Henrike, Koster, Annemarie, van den Hurk, Katja, den Braver, Nicole R., Blom, Marieke T., de Jong, Trynke, Grobbee, Diederick E., Beulens, Joline WJ., and Lakerveld, Jeroen

Published
2024
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12. Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation

Author

Weng, Lu-Chen, Hall, Amelia Weber, Choi, Seung Hoan, Jurgens, Sean J, Haessler, Jeffrey, Bihlmeyer, Nathan A, Grarup, Niels, Lin, Honghuang, Teumer, Alexander, Li-Gao, Ruifang, Yao, Jie, Guo, Xiuqing, Brody, Jennifer A, Müller-Nurasyid, Martina, Schramm, Katharina, Verweij, Niek, van den Berg, Marten E, van Setten, Jessica, Isaacs, Aaron, Ramírez, Julia, Warren, Helen R, Padmanabhan, Sandosh, Kors, Jan A, de Boer, Rudolf A, van der Meer, Peter, Sinner, Moritz F, Waldenberger, Melanie, Psaty, Bruce M, Taylor, Kent D, Völker, Uwe, Kanters, Jørgen K, Li, Man, Alonso, Alvaro, Perez, Marco V, Vaartjes, Ilonca, Bots, Michiel L, Huang, Paul L, Heckbert, Susan R, Lin, Henry J, Kornej, Jelena, Munroe, Patricia B, van Duijn, Cornelia M, Asselbergs, Folkert W, Stricker, Bruno H, van der Harst, Pim, Kääb, Stefan, Peters, Annette, Sotoodehnia, Nona, Rotter, Jerome I, Mook-Kanamori, Dennis O, Dörr, Marcus, Felix, Stephan B, Linneberg, Allan, Hansen, Torben, Arking, Dan E, Kooperberg, Charles, Benjamin, Emelia J, Lunetta, Kathryn L, Ellinor, Patrick T, and Lubitz, Steven A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Research, Genetics, Heart Disease, Cardiovascular, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Atrial Fibrillation, Cardiac Myosins, Connectin, Electrocardiography, Genetic Variation, Genome-Wide Association Study, Homeodomain Proteins, Humans, Myosin Heavy Chains, NAV1.8 Voltage-Gated Sodium Channel, Quantitative Trait Loci, Transcription Factors, atrial fibrillation, electrophysiology, exome, genetic, genome-wide association studies, population, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe P-wave duration (PWD) is an electrocardiographic measurement that represents cardiac conduction in the atria. Shortened or prolonged PWD is associated with atrial fibrillation (AF). We used exome-chip data to examine the associations between common and rare variants with PWD.MethodsFifteen studies comprising 64 440 individuals (56 943 European, 5681 African, 1186 Hispanic, 630 Asian) and ≈230 000 variants were used to examine associations with maximum PWD across the 12-lead ECG. Meta-analyses summarized association results for common variants; gene-based burden and sequence kernel association tests examined low-frequency variant-PWD associations. Additionally, we examined the associations between PWD loci and AF using previous AF genome-wide association studies.ResultsWe identified 21 common and low-frequency genetic loci (14 novel) associated with maximum PWD, including several AF loci (TTN, CAND2, SCN10A, PITX2, CAV1, SYNPO2L, SOX5, TBX5, MYH6, RPL3L). The top variants at known sarcomere genes (TTN, MYH6) were associated with longer PWD and increased AF risk. However, top variants at other loci (eg, PITX2 and SCN10A) were associated with longer PWD but lower AF risk.ConclusionsOur results highlight multiple novel genetic loci associated with PWD, and underscore the shared mechanisms of atrial conduction and AF. Prolonged PWD may be an endophenotype for several different genetic mechanisms of AF.

Published
2020

15. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Author

Prins, Bram P, Mead, Timothy J, Brody, Jennifer A, Sveinbjornsson, Gardar, Ntalla, Ioanna, Bihlmeyer, Nathan A, van den Berg, Marten, Bork-Jensen, Jette, Cappellani, Stefania, Van Duijvenboden, Stefan, Klena, Nikolai T, Gabriel, George C, Liu, Xiaoqin, Gulec, Cagri, Grarup, Niels, Haessler, Jeffrey, Hall, Leanne M, Iorio, Annamaria, Isaacs, Aaron, Li-Gao, Ruifang, Lin, Honghuang, Liu, Ching-Ti, Lyytikäinen, Leo-Pekka, Marten, Jonathan, Mei, Hao, Müller-Nurasyid, Martina, Orini, Michele, Padmanabhan, Sandosh, Radmanesh, Farid, Ramirez, Julia, Robino, Antonietta, Schwartz, Molly, van Setten, Jessica, Smith, Albert V, Verweij, Niek, Warren, Helen R, Weiss, Stefan, Alonso, Alvaro, Arnar, David O, Bots, Michiel L, de Boer, Rudolf A, Dominiczak, Anna F, Eijgelsheim, Mark, Ellinor, Patrick T, Guo, Xiuqing, Felix, Stephan B, Harris, Tamara B, Hayward, Caroline, Heckbert, Susan R, Huang, Paul L, Jukema, JW, Kähönen, Mika, Kors, Jan A, Lambiase, Pier D, Launer, Lenore J, Li, Man, Linneberg, Allan, Nelson, Christopher P, Pedersen, Oluf, Perez, Marco, Peters, Annette, Polasek, Ozren, Psaty, Bruce M, Raitakari, Olli T, Rice, Kenneth M, Rotter, Jerome I, Sinner, Moritz F, Soliman, Elsayed Z, Spector, Tim D, Strauch, Konstantin, Thorsteinsdottir, Unnur, Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Vaartjes, Ilonca, van der Meer, Peter, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Wilson, James G, Xie, Zhijun, Asselbergs, Folkert W, Dörr, Marcus, van Duijn, Cornelia M, Gasparini, Paolo, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hansen, Torben, Kääb, Stefan, Kanters, Jørgen K, Kooperberg, Charles, Lehtimäki, Terho, Lin, Henry J, Lubitz, Steven A, Mook-Kanamori, Dennis O, Conti, Francesco J, Newton-Cheh, Christopher H, Rosand, Jonathan, Rudan, Igor, and Samani, Nilesh J

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Human Genome, Heart Disease, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, ADAMTS Proteins, Animals, Black People, Connexin 43, Electrocardiography, Exome, Female, Gene Expression, Gene Expression Profiling, Genetic Loci, Genome-Wide Association Study, Heart Conduction System, Humans, Male, Mice, Middle Aged, Myocardium, Open Reading Frames, Polymorphism, Single Nucleotide, White People, Exome Sequencing, Exome chip, Conduction, ADAMTS6, Meta-analysis, Environmental Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundGenome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear.ResultsHere, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in our discovery cohort, followed by replication in 111,874 individuals of European ancestry from the UK Biobank and deCODE cohorts. We identify ten novel loci, seven within coding regions, including ADAMTS6, significantly associated with QRS duration in gene-based analyses. ADAMTS6 encodes a secreted metalloprotease of currently unknown function. In vitro validation analysis shows that the QRS-associated variants lead to impaired ADAMTS6 secretion and loss-of function analysis in mice demonstrates a previously unappreciated role for ADAMTS6 in connexin 43 gap junction expression, which is essential for myocardial conduction.ConclusionsOur approach identifies novel coding and non-coding variants underlying ventricular depolarization and provides a possible mechanism for the ADAMTS6-associated conduction changes.

Published
2018

17. Dutch cardio‐oncology cohort: Incident cardiovascular disease predisposes to a higher cancer mortality rate.

Author

Koop, Yvonne, Yousif, Laura, de Boer, Rudolf A., Bots, Michiel L., Meijers, Wouter C., and Vaartjes, Ilonca

Subjects
CANCER-related mortality, PERIPHERAL vascular diseases, HEART failure patients, DEATH rate, CAUSES of death
Abstract

Background: Cardiovascular disease (CVD) and cancer are the two leading causes of death worldwide. Given their high prevalence, it is important to understand the disease burden of cancer mortality in CVD patients. Objective: We aimed to evaluate whether patients with incident CVD have a higher risk of malignancy‐related mortality, compared to the general population without CVD. Methods: We performed a national population‐based cohort study selecting patients with incident CVD in the Netherlands between 01 April 2000 and 31 December 2005. A reference cohort was selected from the Dutch population using age, sex and ethnicity. Mortality follow‐up data were evaluated after data linkage of national registries from Statistics Netherlands until 31 December 2020. Results: A total of 2,240,879 individuals were selected with a mean follow‐up of 12 years (range 0.4–21.0), of which 738,666 patients with incident CVD with a mean age of 71 ± 15 years. Malignancy mortality per 1000 person years was 84 for the reference group and 118 for patients with CVD, with the highest rate of 258 in patients with heart failure. Patients with CVD had a higher malignancy mortality risk, compared to the reference group: HR 1.35 (95%CI 1.33–1.36). Highest risks were observed in patients with venous diseases (HR 2.27, 95%CI 2.17–2.36) and peripheral artery disease (HR 1.87, 95%CI 1.84–2.01). Conclusion: Results show that CVD predisposes to a higher cancer mortality rate. Of all CVD subtypes, HF patients have the highest cancer mortality rate and the hazards were highest in patients with venous diseases and peripheral artery disease. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Taking a Stand Against Air Pollution—The Impact on Cardiovascular Disease: A Joint Opinion from the World Heart Federation, American College of Cardiology, American Heart Association, and the European Society of Cardiology

Author

Brauer, Michael, Davaakhuu, Narantuya, Hadley, Michael, Kass, Daniel, Miller, Mark, Consuelo Escamilla Nuñez, Maria, Prabhakaran, Dorairaj, Su, Ta-Chen, Vaartjes, Ilonca C.H., Vedanthan, Rajesh, Casadei, Barbara, Harrington, Robert A., Kovacs, Richard, and Sliwa, Karen

Published
2021
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22. Discovery of novel heart rate-associated loci using the Exome Chip

Author

van den Berg, Marten E, Warren, Helen R, Cabrera, Claudia P, Verweij, Niek, Mifsud, Borbala, Haessler, Jeffrey, Bihlmeyer, Nathan A, Fu, Yi-Ping, Weiss, Stefan, Lin, Henry J, Grarup, Niels, Li-Gao, Ruifang, Pistis, Giorgio, Shah, Nabi, Brody, Jennifer A, Müller-Nurasyid, Martina, Lin, Honghuang, Mei, Hao, Smith, Albert V, Lyytikäinen, Leo-Pekka, Hall, Leanne M, van Setten, Jessica, Trompet, Stella, Prins, Bram P, Isaacs, Aaron, Radmanesh, Farid, Marten, Jonathan, Entwistle, Aiman, Kors, Jan A, Silva, Claudia T, Alonso, Alvaro, Bis, Joshua C, de Boer, Rudolf, de Haan, Hugoline G, de Mutsert, Renée, Dedoussis, George, Dominiczak, Anna F, Doney, Alex SF, Ellinor, Patrick T, Eppinga, Ruben N, Felix, Stephan B, Guo, Xiuqing, Hagemeijer, Yanick, Hansen, Torben, Harris, Tamara B, Heckbert, Susan R, Huang, Paul L, Hwang, Shih-Jen, Kähönen, Mika, Kanters, Jørgen K, Kolcic, Ivana, Launer, Lenore J, Li, Man, Yao, Jie, Linneberg, Allan, Liu, Simin, Macfarlane, Peter W, Mangino, Massimo, Morris, Andrew D, Mulas, Antonella, Murray, Alison D, Nelson, Christopher P, Orrú, Marco, Padmanabhan, Sandosh, Peters, Annette, Porteous, David J, Poulter, Neil, Psaty, Bruce M, Qi, Lihong, Raitakari, Olli T, Rivadeneira, Fernando, Roselli, Carolina, Rudan, Igor, Sattar, Naveed, Sever, Peter, Sinner, Moritz F, Soliman, Elsayed Z, Spector, Timothy D, Stanton, Alice V, Stirrups, Kathleen E, Taylor, Kent D, Tobin, Martin D, Uitterlinden, André, Vaartjes, Ilonca, Hoes, Arno W, van der Meer, Peter, Völker, Uwe, Waldenberger, Melanie, Xie, Zhijun, Zoledziewska, Magdalena, Tinker, Andrew, Polasek, Ozren, Rosand, Jonathan, Jamshidi, Yalda, van Duijn, Cornelia M, Zeggini, Eleftheria, Jukema, J Wouter, Asselbergs, Folkert W, Samani, Nilesh J, and Lehtimäki, Terho

Subjects
Biological Sciences, Genetics, Human Genome, Biotechnology, Heart Disease, Prevention, Cardiovascular, Stem Cell Research, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adult, Alleles, Exome, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Heart Rate, Humans, Male, Middle Aged, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Risk Factors, White People, Medical and Health Sciences, Genetics & Heredity
Abstract

Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation. This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses.Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association results from 104 452 European-ancestry individuals from 30 cohorts, genotyped using the Exome Chip. Twenty-four variants were selected for follow-up in an independent dataset (UK Biobank, N = 134 251). Conditional and gene-based testing was undertaken, and variants were investigated with bioinformatics methods.We discovered five novel heart rate loci, and one new independent low-frequency non-synonymous variant in an established heart rate locus (KIAA1755). Lead variants in four of the novel loci are non-synonymous variants in the genes C10orf71, DALDR3, TESK2 and SEC31B. The variant at SEC31B is significantly associated with SEC31B expression in heart and tibial nerve tissue. Further candidate genes were detected from long-range regulatory chromatin interactions in heart tissue (SCD, SLF2 and MAPK8). We observed significant enrichment in DNase I hypersensitive sites in fetal heart and lung. Moreover, enrichment was seen for the first time in human neuronal progenitor cells (derived from embryonic stem cells) and fetal muscle samples by including our novel variants.Our findings advance the knowledge of the genetic architecture of heart rate, and indicate new candidate genes for follow-up functional studies.

Published
2017

23. Ethnic and socioeconomic inequalities in air pollution exposure: a cross-sectional analysis of nationwide individual-level data from the Netherlands

Author

van den Brekel, Lieke, Lenters, Virissa, Mackenbach, Joreintje D., Hoek, Gerard, Wagtendonk, Alfred, Lakerveld, Jeroen, Grobbee, Diederick E., Vaartjes, Ilonca, van den Brekel, Lieke, Lenters, Virissa, Mackenbach, Joreintje D., Hoek, Gerard, Wagtendonk, Alfred, Lakerveld, Jeroen, Grobbee, Diederick E., and Vaartjes, Ilonca

Abstract

Background: Air pollution contributes to a large disease burden and some populations are disproportionately exposed. We aimed to evaluate ethnic and socioeconomic differences in exposure to air pollution in the Netherlands. Methods: We did a nationwide, cross-sectional analysis of all residents of the Netherlands on Jan 1, 2019. Sociodemographic information was centralised by Statistics Netherlands and mainly originated from the National Population Register, the tax register, and education registers. Concentrations of NO2, PM2·5, PM10, and elemental carbon, modelled by the National Institute for Public Health and the Environment, were linked to the individual-level demographic data. We assessed differences in air pollution exposures across the 40 largest minority ethnic groups. Evaluation of how ethnicity intersected with socioeconomic position in relation to exposures was done for the ten largest ethnic groups, plus Chinese and Indian groups, in both urban and rural areas using multivariable linear regression analyses. Findings: The total study population consisted of 17 251 511 individuals. Minority ethnic groups were consistently exposed to higher levels of air pollution than the ethnic Dutch population. The magnitude of inequalities varied between the minority ethnic groups, with 3–44% higher exposures to NO2 and 1–9% higher exposures to PM2·5 compared with the ethnic Dutch group. Average exposures were highest for the lowest socioeconomic group. Ethnic inequalities in exposure remained after adjustment for socioeconomic position and were of similar magnitude in urban and rural areas. Interpretation: The variability in air pollution exposure across ethnic and socioeconomic subgroups in the Netherlands indicates environmental injustice at the intersection of social characteristics. The health consequences of the observed inequalities and the underlying processes driving them warrant further investigation.

Published
2024

24. Does Heterogeneity Exist in Treatment Associations With Renin–Angiotensin–System Inhibitors or Beta-blockers According to Phenotype Clusters in Heart Failure with Preserved Ejection Fraction?

Author

Cardiometabolic Health, Cardiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Global Health, UIJL, ALICIA, KOUDSTAAL, STEFAN, STOLFO, DAVIDE, DAHLSTRÖM, U. L.F., VAARTJES, ILONCA, GROBBEE, RICK E., ASSELBERGS, FOLKERT W., LUND, LARS H., SAVARESE, GIANLUIGI, Cardiometabolic Health, Cardiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Global Health, UIJL, ALICIA, KOUDSTAAL, STEFAN, STOLFO, DAVIDE, DAHLSTRÖM, U. L.F., VAARTJES, ILONCA, GROBBEE, RICK E., ASSELBERGS, FOLKERT W., LUND, LARS H., and SAVARESE, GIANLUIGI

Published
2024

25. Longitudinal associations of air pollution and green space with cardiometabolic risk factor clustering among children in the Netherlands

Author

Global Health, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Liu, Mingwei, Vaartjes, Ilonca, Hoek, Gerard, Jaddoe, Vincent W V, Santos, Susana, Schreuder, Anton, Vrijkotte, Tanja G M, Grobbee, Diederick E, Timmermans, Erik J, Global Health, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Liu, Mingwei, Vaartjes, Ilonca, Hoek, Gerard, Jaddoe, Vincent W V, Santos, Susana, Schreuder, Anton, Vrijkotte, Tanja G M, Grobbee, Diederick E, and Timmermans, Erik J

Published
2024

26. The association of obesogenic environments with weight status, blood pressure, and blood lipids: A cross-sectional pooled analysis across five cohorts

Author

Cardiometabolic Health, Cardiovasculaire Epi Team 7B, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Global Health, Meijer, Paul, Lam, Thao Minh, Vaartjes, Ilonca, Moll van Charante, Eric, Galenkamp, Henrike, Koster, Annemarie, van den Hurk, Katja, den Braver, Nicole R., Blom, Marieke T., de Jong, Trynke, Grobbee, Diederick E., Beulens, Joline WJ, Lakerveld, Jeroen, GECCO Consortium, Cardiometabolic Health, Cardiovasculaire Epi Team 7B, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Global Health, Meijer, Paul, Lam, Thao Minh, Vaartjes, Ilonca, Moll van Charante, Eric, Galenkamp, Henrike, Koster, Annemarie, van den Hurk, Katja, den Braver, Nicole R., Blom, Marieke T., de Jong, Trynke, Grobbee, Diederick E., Beulens, Joline WJ, Lakerveld, Jeroen, and GECCO Consortium

Published
2024

27. Impact of green space exposure on blood pressure in Guangzhou, China: Mediation by air pollution, mental health, physical activity, and weight status

Author

Global Health, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Liu, Mingwei, Timmermans, Erik J., Zou, Dan, Grobbee, Diederick E., Zhou, Suhong, Vaartjes, Ilonca, Global Health, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Liu, Mingwei, Timmermans, Erik J., Zou, Dan, Grobbee, Diederick E., Zhou, Suhong, and Vaartjes, Ilonca

Published
2024

28. Influenza Infection and Acute Myocardial Infarction

Author

Infection & Immunity, Epi Infectieziekten Team 1, MMB Zorg, MMB opleiding Arts microbioloog, Child Health, JC onderzoeksprogramma Methodologie, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, de Boer, Annemarijn R, Riezebos-Brilman, Annelies, van Hout, Denise, van Mourik, Maaike S M, Rümke, Lidewij W, de Hoog, Marieke L A, Vaartjes, Ilonca, Bruijning-Verhagen, Patricia C J L, Infection & Immunity, Epi Infectieziekten Team 1, MMB Zorg, MMB opleiding Arts microbioloog, Child Health, JC onderzoeksprogramma Methodologie, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, de Boer, Annemarijn R, Riezebos-Brilman, Annelies, van Hout, Denise, van Mourik, Maaike S M, Rümke, Lidewij W, de Hoog, Marieke L A, Vaartjes, Ilonca, and Bruijning-Verhagen, Patricia C J L

Published
2024

29. Octopus follow-up: 20 year prognosis in patients randomized to on-pump CABG, off-pump CABG or PCI

Author

Circulatory Health, Cancer, Cardiometabolic Health, Team Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, Global Health, CTC, Medische Staf Intensive Care, Brain, Koop, Yvonne, Nathoe, Hendrik, Bots, Michiel, Grobbee, Diederick E, Timmermans, Marijke, Wimmers, Raymond H, Gianoli, Monica, van Dijk, Diederik, Vaartjes, Ilonca, PCI and Cardiothoracic Surgery Registration Committees of the Netherlands Heart Registration (Appendix 1), Circulatory Health, Cancer, Cardiometabolic Health, Team Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, Global Health, CTC, Medische Staf Intensive Care, Brain, Koop, Yvonne, Nathoe, Hendrik, Bots, Michiel, Grobbee, Diederick E, Timmermans, Marijke, Wimmers, Raymond H, Gianoli, Monica, van Dijk, Diederik, Vaartjes, Ilonca, and PCI and Cardiothoracic Surgery Registration Committees of the Netherlands Heart Registration (Appendix 1)

Published
2024

30. The neighourhood obesogenic built environment characteristics (OBCT) index: Practice versus theory

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lam, Thao Minh, den Braver, Nicolette R., Ohanyan, Haykanush, Wagtendonk, Alfred J., Vaartjes, Ilonca, Beulens, Joline WJ, Lakerveld, Jeroen, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Lam, Thao Minh, den Braver, Nicolette R., Ohanyan, Haykanush, Wagtendonk, Alfred J., Vaartjes, Ilonca, Beulens, Joline WJ, and Lakerveld, Jeroen

Published
2024

32. A Global Perspective on Cardiovascular Risk Factors by Educational Level in CHD Patients: Surf Chd Ii

Author

Global Health team 1, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 5, Global Public Health & Bioethics, Global Health, Marzà-Florensa, Anna, Vaartjes, Ilonca, Graham, Ian, Klipstein-Grobusch, Kerstin, Grobbee, Diederick E, Surf CHD II collaborators, Global Health team 1, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 5, Global Public Health & Bioethics, Global Health, Marzà-Florensa, Anna, Vaartjes, Ilonca, Graham, Ian, Klipstein-Grobusch, Kerstin, Grobbee, Diederick E, and Surf CHD II collaborators

Published
2024

33. Dutch cardio-oncology cohort:Incident cardiovascular disease predisposes to a higher cancer mortality rate

Author

Koop, Yvonne, Yousif, Laura, de Boer, Rudolf A., Bots, Michiel L., Meijers, Wouter C., Vaartjes, Ilonca, Koop, Yvonne, Yousif, Laura, de Boer, Rudolf A., Bots, Michiel L., Meijers, Wouter C., and Vaartjes, Ilonca

Abstract

Background: Cardiovascular disease (CVD) and cancer are the two leading causes of death worldwide. Given their high prevalence, it is important to understand the disease burden of cancer mortality in CVD patients. Objective: We aimed to evaluate whether patients with incident CVD have a higher risk of malignancy-related mortality, compared to the general population without CVD. Methods: We performed a national population-based cohort study selecting patients with incident CVD in the Netherlands between 01 April 2000 and 31 December 2005. A reference cohort was selected from the Dutch population using age, sex and ethnicity. Mortality follow-up data were evaluated after data linkage of national registries from Statistics Netherlands until 31 December 2020. Results: A total of 2,240,879 individuals were selected with a mean follow-up of 12 years (range 0.4–21.0), of which 738,666 patients with incident CVD with a mean age of 71 ± 15 years. Malignancy mortality per 1000 person years was 84 for the reference group and 118 for patients with CVD, with the highest rate of 258 in patients with heart failure. Patients with CVD had a higher malignancy mortality risk, compared to the reference group: HR 1.35 (95%CI 1.33–1.36). Highest risks were observed in patients with venous diseases (HR 2.27, 95%CI 2.17–2.36) and peripheral artery disease (HR 1.87, 95%CI 1.84–2.01). Conclusion:Results show that CVD predisposes to a higher cancer mortality rate. Of all CVD subtypes, HF patients have the highest cancer mortality rate and the hazards were highest in patients with venous diseases and peripheral artery disease.

Published
2024

34. Sex Differences in Mortality Risk after the First Hospitalisation with Lower Extremity Peripheral Arterial Disease

Author

Nefro Vasculaire Geneeskunde, Infection & Immunity, Epi Infectieziekten Team 1, Cardiometabolic Health, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, MS Nefrologie, Porras, Cindy P, de Boer, Annemarijn R, Koop, Yvonne, Vaartjes, Ilonca, Teraa, Martin, Hazenberg, Constantijn E V B, Verhaar, Marianne C, Vernooij, Robin W M, Nefro Vasculaire Geneeskunde, Infection & Immunity, Epi Infectieziekten Team 1, Cardiometabolic Health, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, MS Nefrologie, Porras, Cindy P, de Boer, Annemarijn R, Koop, Yvonne, Vaartjes, Ilonca, Teraa, Martin, Hazenberg, Constantijn E V B, Verhaar, Marianne C, and Vernooij, Robin W M

Published
2024

35. Dutch cardio-oncology cohort: Incident cardiovascular disease predisposes to a higher cancer mortality rate

Author

Cardiometabolic Health, Cancer, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Koop, Yvonne, Yousif, Laura, de Boer, Rudolf A, Bots, Michiel L, Meijers, Wouter C, Vaartjes, Ilonca, Cardiometabolic Health, Cancer, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Koop, Yvonne, Yousif, Laura, de Boer, Rudolf A, Bots, Michiel L, Meijers, Wouter C, and Vaartjes, Ilonca

Published
2024

36. Temporal Trends in Air Pollution Exposure across Socioeconomic Groups in The Netherlands

Author

Cardiometabolic Health, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Hlubek, Niklas, Koop, Yvonne, Wagtendonk, Alfred, Vaartjes, Ilonca, Cardiometabolic Health, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Hlubek, Niklas, Koop, Yvonne, Wagtendonk, Alfred, and Vaartjes, Ilonca

Published
2024

38. Ethnic and socioeconomic inequalities in air pollution exposure: a cross-sectional analysis of nationwide individual-level data from the Netherlands

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van den Brekel, Lieke, Lenters, Virissa, Mackenbach, Joreintje D., Hoek, Gerard, Wagtendonk, Alfred, Lakerveld, Jeroen, Grobbee, Diederick E., Vaartjes, Ilonca, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van den Brekel, Lieke, Lenters, Virissa, Mackenbach, Joreintje D., Hoek, Gerard, Wagtendonk, Alfred, Lakerveld, Jeroen, Grobbee, Diederick E., and Vaartjes, Ilonca

Published
2024

39. The neighourhood obesogenic built environment characteristics (OBCT) index: Practice versus theory

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Lam, Thao Minh, den Braver, Nicolette R., Ohanyan, Haykanush, Wagtendonk, Alfred J., Vaartjes, Ilonca, Beulens, Joline WJ, Lakerveld, Jeroen, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Lam, Thao Minh, den Braver, Nicolette R., Ohanyan, Haykanush, Wagtendonk, Alfred J., Vaartjes, Ilonca, Beulens, Joline WJ, and Lakerveld, Jeroen

Published
2024

40. Congestive Heart Failure in Daily Practice: A Review of Recent, General Practice- and Community-Centred CHF Epidemiology

Author

Read, Christina, Vaartjes, Ilonca (Thesis Advisor), Read, Christina, and Vaartjes, Ilonca (Thesis Advisor)

Abstract

Purpose: Congestive heart failure (CHF) is a prevalent cardiovascular disorder with a large global impact, characterised by heterogeneous presentation and generally separated into three major categories: heart failure with reduced (HFrEF), mid-range (HFmEF), and preserved ejection fraction (HFpEF). Although research generally utilises randomised control trials and often focuses on hospitalised patient populations, a large proportion of patients with CHF are treated in general practice, so it is important to understand patient population, management, and prognosis of CHF in this setting. Previous reviews focused on CHF in general practice were published upwards of 20 years ago, so this review looked at recent studies in order to understand the epidemiology of CHF in general practice in a contemporary context. Findings: Findings highlight a decline in incidence and an increase in prevalence, with a higher prevalence and incidence among men and older patients. Common comorbidities include hypertension, atrial fibrillation, and ischemic heart disease, but there are differences in comorbidities associated with ejection fraction and sex. Low rates of test availability as well as practitioners’ confidence in interpretation of results may both be factors in overall low rates of diagnostic testing before diagnosis in general practice. Common medications prescribed by general practitioners included beta-blockers, diuretics, mineralocorticoid receptor antagonist medications, and renin-angiotensin system inhibitors, but guideline adherence was generally low, and general practitioners found guidelines much more helpful in the management of HFrEF compared to HFpEF. Mortality is decreasing overall, and this is mostly driven by decreases particularly among men and patients with HFrEF. Hospitalisation accounts for the largest proportion of healthcare costs associated with CHF, even among patients treated within general practice. Conclusion: This review emphasises the need for future

Published
2024

42. Influenza Infection and Acute Myocardial Infarction.

Author

de Boer, Annemarijn R., Riezebos-Brilman, Annelies, van Hout, Denise, van Mourik, Maaike S. M., Rümke, Lidewij W., de Hoog, Marieke L. A., Vaartjes, Ilonca, and Bruijning-Verhagen, Patricia C. J. L.

Subjects
MYOCARDIAL infarction risk factors, INFLUENZA complications, RISK assessment, MYOCARDIAL infarction, SCIENTIFIC observation, POLYMERASE chain reaction, HOSPITAL care, REPORTING of diseases, CORONARY artery disease, CONFIDENCE intervals, COMPARATIVE studies
Abstract

Background: Acute respiratory infections can trigger acute myocardial infarction. We aimed to quantify the association between laboratory-confirmed influenza infection and acute myocardial infarction, particularly in patients with and without known coronary artery disease. Methods: This observational, registry-based, self-controlled case series study evaluated the association between laboratory-confirmed influenza infection and occurrence of acute myocardial infarction. Laboratory records on respiratory virus polymerase chain reaction (PCR) testing from 16 laboratories across the Netherlands were linked to national mortality, hospitalization, medication, and administrative registries. Influenza infection was defined as a positive PCR test result. Acute myocardial infarction was defined as a registered diagnostic code for either acute myocardial infarction hospitalization or death. Using a self-controlled case series method, we then compared the incidence of acute myocardial infarction during the risk period (days 1 to 7 after influenza infection) versus the control period (1 year before and 51 weeks after the risk period). Results: Between 2008 and 2019, we identified 158,777 PCR tests for influenza in the study population; 26,221 were positive for influenza, constituting 23,405 unique influenza illness episodes. A total of 406 episodes were identified with acute myocardial infarction occurring within 1 year before and 1 year after confirmed influenza infection and were included in analysis. Twenty-five cases of acute myocardial infarction occurred during the risk period versus 394 during the control period. The adjusted relative incidence of acute myocardial infarction during the risk period compared with the control period was 6.16 (95% confidence interval [CI], 4.11 to 9.24). The relative incidence of acute myocardial infarction in individuals without prior hospitalization for coronary artery disease was 16.60 (95% CI, 10.45 to 26.37) compared with 1.43 (95% CI, 0.53 to 3.84) for those with prior admission for coronary artery disease. Conclusions: Influenza infection was associated with an increased risk of acute myocardial infarction, especially in individuals without a prior hospitalization for coronary artery disease. (Funded by the Dutch Research Council [NWO].) [ABSTRACT FROM AUTHOR]

Published
2024
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49. Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Author

Surendran, Praveen, Young, Robin, Barnes, Daniel R., Nielsen, Sune Fallgaard, Rasheed, Asif, Samuel, Maria, Zhao, Wei, Kontto, Jukka, Perola, Markus, Caslake, Muriel, de Craen, Anton J.M., Trompet, Stella, Uria-Nickelsen, Maria, Malarstig, Anders, Reily, Dermot F., Hoek, Maarten, Vogt, Thomas, Jukema, J. Wouter, Sattar, Naveed, Ford, Ian, Packard, Chris J., Alam, Dewan S., Majumder, Abdulla al Shafi, Di Angelantonio, Emanuele, Chowdhury, Rajiv, Amouyel, Philippe, Arveiler, Dominique, Blankenberg, Stefan, Ferrières, Jean, Kee, Frank, Kuulasmaa, Kari, Müller-Nurasyid, Martina, Veronesi, Giovanni, Virtamo, Jarmo, EPIC-CVD Consortium, Frossard, Philippe, Nordestgaard, Børge Grønne, Saleheen, Danish, Danesh, John, Butterworth, Adam S., Howson, Joanna M.M., Erzurumluoglu, A. Mesut, Jackson, Victoria E., Melbourne, Carl A., Varga, Tibor V., Warren, Helen R., Tragante, Vinicius, Tachmazidou, Ioanna, Harris, Sarah E., Evangelou, Evangelos, Marten, Jonathan, Zhang, Weihua, Altmaier, Elisabeth, Luan, Jian’an, Langenberg, Claudia, Scott, Robert A., Yaghootkar, Hanieh, Stirrups, Kathleen, Kanoni, Stavroula, Marouli, Eirini, Karpe, Fredrik, Dominiczak, Anna F., Sever, Peter, Poulter, Neil, Rolandsson, Olov, Baumbach, Clemens, Afaq, Saima, Chambers, John C., Kooner, Jaspal S., Wareham, Nicholas J., Renström, Frida, Hallmans, Göran, Marioni, Riccardo E., Corley, Janie, Starr, John M., Verweij, Niek, de Boer, Rudolf A., van der Meer, Peter, Yavas, Ersin, Vaartjes, Ilonca, Bots, Michiel L., Asselbergs, Folkert W., Grabe, Hans J., Völzke, Henry, Nauck, Matthias, Weiss, Stefan, Pharoah, Paul D.P., Dunning, Alison M., Dennis, Joe G., Thompson, Deborah J., Michailidou, Kyriaki, Easton, Douglas F., Antoniou, Antonis C., Tyrrell, Jessica, Mihailov, Evelin, Samani, Nilesh J., Zhou, Kaixin, Neville, Matthew J., Metspalu, Andres, Palmer, Colin N.A., Hall, Ian P., Strachan, David P., Deary, Ian J., Frayling, Tim M., Hayward, Caroline, van der Harst, Pim, Zeggini, Eleftheria, Understanding Society Scientific Group, Munroe, Patricia B., Jansson, Jan-Håkan, Franks, Paul W., Deloukas, Panos, Caulfield, Mark J., Wain, Louise V., Tobin, Martin D., Brazel, David M., Jiang, Yu, Hughey, Jordan M., Turcot, Valérie, Zhan, Xiaowei, Gong, Jian, Batini, Chiara, Weissenkampen, J. Dylan, Liu, MengZhen, Bertelsen, Sarah, Chou, Yi-Ling, Faul, Jessica D., Haessler, Jeff, Hammerschlag, Anke R., Hsu, Chris, Kapoor, Manav, Lai, Dongbing, Le, Nhung, de Leeuw, Christiaan A., Loukola, Anu, Mangino, Massimo, Pistis, Giorgio, Qaiser, Beenish, Rohde, Rebecca, Shao, Yaming, Stringham, Heather, Wetherill, Leah, Agrawal, Arpana, Bierut, Laura, Chen, Chu, Eaton, Charles B., Goate, Alison, Haiman, Christopher, Heath, Andrew, Iacono, William G., Martin, Nicholas G., Polderman, Tinca J., Reiner, Alex, Rice, John, Schlessinger, David, Scholte, H. Steven, Smith, Jennifer A., Tardif, Jean-Claude, Tindle, Hilary A., van der Leij, Andries R., Boehnke, Michael, Chang-Claude, Jenny, Cucca, Francesco, David, Sean P., Foroud, Tatiana, Kardia, Sharon L.R., Kooperberg, Charles, Laakso, Markku, Lettre, Guillaume, Madden, Pamela, McGue, Matt, North, Kari, Posthuma, Danielle, Spector, Timothy, Stram, Daniel, Weir, David R., Kaprio, Jaakko, Abecasis, Gonçalo R., Liu, Dajiang J., and Vrieze, Scott

Published
2019
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