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2. A semi-parametric estimation for max-mixture spatial processes

Author

Ahmed, M., Maume-Deschamps, V, Ribereau, P., and Vial, C.

Subjects
Mathematics - Statistics Theory, Mathematics - Probability
Abstract

We proposed a semi-parametric estimation procedure in order to estimate the parameters of a max-mixture model and also of a max-stable model (inverse max-stable model) as an alternative to composite likelihood. A good estimation by the proposed estimator required the dependence measure to detect all dependence structures in the model, especially when dealing with the max-mixture model. We overcame this challenge by using the F-madogram. The semi-parametric estimation was then based on a quasi least square method, by minimizing the square difference between the theoretical F-madogram and an empirical one. We evaluated the performance of this estimator through a simulation study. It was shown that on an average, the estimation is performed well, although in some cases, it encountered some difficulties. We apply our estimation procedure to model the daily rainfalls over the East Australia.

Published
2017

7. Somatosensory evoked potentials in the assessment of peripheral neuropathies: Commented results of a survey among French-speaking practitioners and recommendations for practice

Author

Morizot-Koutlidis, R., André-Obadia, N., Antoine, J.-C., Attarian, S., Ayache, S.S., Azabou, E., Benaderette, S., Camdessanché, J.-P., Cassereau, J., Convers, P., d’Anglejean, J., Delval, A., Durand, M.-C., Etard, O., Fayet, G., Fournier, E., Franques, J., Gavaret, M., Guehl, D., Guerit, J.-M., Krim, E., Kubis, N., Lacour, A., Lozeron, P., Mauguière, F., Merle, P.-E., Mesrati, F., Mutschler, V., Nicolas, G., Nordine, T., Pautot, V., Péréon, Y., Petiot, P., Pouget, J., Praline, J., Salhi, H., Trébuchon, A., Tyvaert, L., Vial, C., Zola, J.-M., Zyss, J., and Lefaucheur, J.-P.

Published
2015
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13. Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19

Author

Carmona-Rivera, C, Zhang, Y, Dobbs, K, Markowitz, T, Dalgard, C, Oler, A, Claybaugh, D, Draper, D, Truong, M, Delmonte, O, Licciardi, F, Ramenghi, U, Crescenzio, N, Imberti, L, Sottini, A, Quaresima, V, Fiorini, C, Discepolo, V, Lo Vecchio, A, Guarino, A, Pierri, L, Catzola, A, Biondi, A, Bonfanti, P, Poli Harlowe, M, Espinosa, Y, Astudillo, C, Rey-Jurado, E, Vial, C, De la Cruz, J, Gonzalez, R, Pinera, C, Mays, J, Ng, A, Platt, A, Drolet, B, Moon, J, Cowen, E, Kenney, H, Weber, S, Castagnoli, R, Magliocco, M, Stack, M, Montealegre Sanchez, G, Barron, K, Fink, D, Kuhns, D, Hewitt, S, Arkin, L, Chertow, D, Su, H, Notarangelo, L, Kaplan, M, Carmona-Rivera, Carmelo, Zhang, Yu, Dobbs, Kerry, Markowitz, Tovah E, Dalgard, Clifton L, Oler, Andrew J, Claybaugh, Dillon R, Draper, Deborah, Truong, Meng, Delmonte, Ottavia M, Licciardi, Francesco, Ramenghi, Ugo, Crescenzio, Nicoletta, Imberti, Luisa, Sottini, Alessandra, Quaresima, Virginia, Fiorini, Chiara, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Pierri, Luca, Catzola, Andrea, Biondi, Andrea, Bonfanti, Paolo, Poli Harlowe, Maria Cecilia, Espinosa, Yazmin, Astudillo, Camila A, Rey-Jurado, Emma, Vial, Cecilia, De la Cruz, Javiera, Gonzalez, Ricardo, Pinera, Cecilia, Mays, Jacqueline W, Ng, Ashley, Platt, Andrew, Drolet, Beth A, Moon, John, Cowen, Edward W, Kenney, Heather, Weber, Sarah E, Castagnoli, Riccardo, Magliocco, Mary K, Stack, Michael Austin, Montealegre Sanchez, Gina A, Barron, Karyl, Fink, Danielle L, Kuhns, Douglas B, Hewitt, Stephen M, Arkin, Lisa M, Chertow, Daniel S, Su, Helen C, Notarangelo, Luigi D, Kaplan, Mariana J, Carmona-Rivera, C, Zhang, Y, Dobbs, K, Markowitz, T, Dalgard, C, Oler, A, Claybaugh, D, Draper, D, Truong, M, Delmonte, O, Licciardi, F, Ramenghi, U, Crescenzio, N, Imberti, L, Sottini, A, Quaresima, V, Fiorini, C, Discepolo, V, Lo Vecchio, A, Guarino, A, Pierri, L, Catzola, A, Biondi, A, Bonfanti, P, Poli Harlowe, M, Espinosa, Y, Astudillo, C, Rey-Jurado, E, Vial, C, De la Cruz, J, Gonzalez, R, Pinera, C, Mays, J, Ng, A, Platt, A, Drolet, B, Moon, J, Cowen, E, Kenney, H, Weber, S, Castagnoli, R, Magliocco, M, Stack, M, Montealegre Sanchez, G, Barron, K, Fink, D, Kuhns, D, Hewitt, S, Arkin, L, Chertow, D, Su, H, Notarangelo, L, Kaplan, M, Carmona-Rivera, Carmelo, Zhang, Yu, Dobbs, Kerry, Markowitz, Tovah E, Dalgard, Clifton L, Oler, Andrew J, Claybaugh, Dillon R, Draper, Deborah, Truong, Meng, Delmonte, Ottavia M, Licciardi, Francesco, Ramenghi, Ugo, Crescenzio, Nicoletta, Imberti, Luisa, Sottini, Alessandra, Quaresima, Virginia, Fiorini, Chiara, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Pierri, Luca, Catzola, Andrea, Biondi, Andrea, Bonfanti, Paolo, Poli Harlowe, Maria Cecilia, Espinosa, Yazmin, Astudillo, Camila A, Rey-Jurado, Emma, Vial, Cecilia, De la Cruz, Javiera, Gonzalez, Ricardo, Pinera, Cecilia, Mays, Jacqueline W, Ng, Ashley, Platt, Andrew, Drolet, Beth A, Moon, John, Cowen, Edward W, Kenney, Heather, Weber, Sarah E, Castagnoli, Riccardo, Magliocco, Mary K, Stack, Michael Austin, Montealegre Sanchez, Gina A, Barron, Karyl, Fink, Danielle L, Kuhns, Douglas B, Hewitt, Stephen M, Arkin, Lisa M, Chertow, Daniel S, Su, Helen C, Notarangelo, Luigi D, and Kaplan, Mariana J

Abstract

Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease, including multisystem inflammatory syndrome in children (MIS-C) and chilblain-like lesions (CLLs), otherwise known as "COVID toes,"remains unclear. Studying multinational cohorts, we found that, in CLLs, NETs were significantly increased in serum and skin. There was geographic variability in the prevalence of increased NETs in MIS-C, in association with disease severity. MIS-C and CLL serum samples displayed decreased NET degradation ability, in association with C1q and G-actin or anti-NET antibodies, respectively, but not with genetic variants of DNases. In adult COVID-19, persistent elevations in NETs after disease diagnosis were detected but did not occur in asymptomatic infection. COVID-19-affected adults displayed significant prevalence of impaired NET degradation, in association with anti-DNase1L3, G-actin, and specific disease manifestations, but not with genetic variants of DNases. NETs were detected in many organs of adult patients who died from COVID-19 complications. Infection with the Omicron variant was associated with decreased NET levels when compared with other SARS-CoV-2 strains. These data support a role for NETs in the pathogenesis and severity of COVID-19 in pediatric and adult patients.

Published
2022

14. Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Author

Sacco, K, Castagnoli, R, Vakkilainen, S, Liu, C, Delmonte, O, Oguz, C, Kaplan, I, Alehashemi, S, Burbelo, P, Bhuyan, F, de Jesus, A, Dobbs, K, Rosen, L, Cheng, A, Shaw, E, Vakkilainen, M, Pala, F, Lack, J, Zhang, Y, Fink, D, Oikonomou, V, Snow, A, Dalgard, C, Chen, J, Sellers, B, Montealegre Sanchez, G, Barron, K, Rey-Jurado, E, Vial, C, Poli, M, Licari, A, Montagna, D, Marseglia, G, Licciardi, F, Ramenghi, U, Discepolo, V, Lo Vecchio, A, Guarino, A, Eisenstein, E, Imberti, L, Sottini, A, Biondi, A, Mató, S, Gerstbacher, D, Truong, M, Stack, M, Magliocco, M, Bosticardo, M, Kawai, T, Danielson, J, Hulett, T, Askenazi, M, Hu, S, Cohen, J, Su, H, Kuhns, D, Lionakis, M, Snyder, T, Holland, S, Goldbach-Mansky, R, Tsang, J, Notarangelo, L, Sacco, Keith, Castagnoli, Riccardo, Vakkilainen, Svetlana, Liu, Can, Delmonte, Ottavia M, Oguz, Cihan, Kaplan, Ian M, Alehashemi, Sara, Burbelo, Peter D, Bhuyan, Farzana, de Jesus, Adriana A, Dobbs, Kerry, Rosen, Lindsey B, Cheng, Aristine, Shaw, Elana, Vakkilainen, Mikko S, Pala, Francesca, Lack, Justin, Zhang, Yu, Fink, Danielle L, Oikonomou, Vasileios, Snow, Andrew L, Dalgard, Clifton L, Chen, Jinguo, Sellers, Brian A, Montealegre Sanchez, Gina A, Barron, Karyl, Rey-Jurado, Emma, Vial, Cecilia, Poli, Maria Cecilia, Licari, Amelia, Montagna, Daniela, Marseglia, Gian Luigi, Licciardi, Francesco, Ramenghi, Ugo, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Eisenstein, Eli M, Imberti, Luisa, Sottini, Alessandra, Biondi, Andrea, Mató, Sayonara, Gerstbacher, Dana, Truong, Meng, Stack, Michael A, Magliocco, Mary, Bosticardo, Marita, Kawai, Tomoki, Danielson, Jeffrey J, Hulett, Tyler, Askenazi, Manor, Hu, Shaohui, Cohen, Jeffrey I, Su, Helen C, Kuhns, Douglas B, Lionakis, Michail S, Snyder, Thomas M, Holland, Steven M, Goldbach-Mansky, Raphaela, Tsang, John S, Notarangelo, Luigi D, Sacco, K, Castagnoli, R, Vakkilainen, S, Liu, C, Delmonte, O, Oguz, C, Kaplan, I, Alehashemi, S, Burbelo, P, Bhuyan, F, de Jesus, A, Dobbs, K, Rosen, L, Cheng, A, Shaw, E, Vakkilainen, M, Pala, F, Lack, J, Zhang, Y, Fink, D, Oikonomou, V, Snow, A, Dalgard, C, Chen, J, Sellers, B, Montealegre Sanchez, G, Barron, K, Rey-Jurado, E, Vial, C, Poli, M, Licari, A, Montagna, D, Marseglia, G, Licciardi, F, Ramenghi, U, Discepolo, V, Lo Vecchio, A, Guarino, A, Eisenstein, E, Imberti, L, Sottini, A, Biondi, A, Mató, S, Gerstbacher, D, Truong, M, Stack, M, Magliocco, M, Bosticardo, M, Kawai, T, Danielson, J, Hulett, T, Askenazi, M, Hu, S, Cohen, J, Su, H, Kuhns, D, Lionakis, M, Snyder, T, Holland, S, Goldbach-Mansky, R, Tsang, J, Notarangelo, L, Sacco, Keith, Castagnoli, Riccardo, Vakkilainen, Svetlana, Liu, Can, Delmonte, Ottavia M, Oguz, Cihan, Kaplan, Ian M, Alehashemi, Sara, Burbelo, Peter D, Bhuyan, Farzana, de Jesus, Adriana A, Dobbs, Kerry, Rosen, Lindsey B, Cheng, Aristine, Shaw, Elana, Vakkilainen, Mikko S, Pala, Francesca, Lack, Justin, Zhang, Yu, Fink, Danielle L, Oikonomou, Vasileios, Snow, Andrew L, Dalgard, Clifton L, Chen, Jinguo, Sellers, Brian A, Montealegre Sanchez, Gina A, Barron, Karyl, Rey-Jurado, Emma, Vial, Cecilia, Poli, Maria Cecilia, Licari, Amelia, Montagna, Daniela, Marseglia, Gian Luigi, Licciardi, Francesco, Ramenghi, Ugo, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Eisenstein, Eli M, Imberti, Luisa, Sottini, Alessandra, Biondi, Andrea, Mató, Sayonara, Gerstbacher, Dana, Truong, Meng, Stack, Michael A, Magliocco, Mary, Bosticardo, Marita, Kawai, Tomoki, Danielson, Jeffrey J, Hulett, Tyler, Askenazi, Manor, Hu, Shaohui, Cohen, Jeffrey I, Su, Helen C, Kuhns, Douglas B, Lionakis, Michail S, Snyder, Thomas M, Holland, Steven M, Goldbach-Mansky, Raphaela, Tsang, John S, and Notarangelo, Luigi D

Abstract

Transcriptomic, proteomic and immune repertoire profiling reveals distinct peripheral features of MIS-C and pediatric COVID-19, including elevated soluble spike protein levels, more pronounced type II IFN-dependent gene expression and a higher B cell mutation rate in patients with MIS-C.Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might develop multisystem inflammatory syndrome in children (MIS-C), with substantial morbidity. In this longitudinal multi-institutional study, we applied multi-omics (analysis of soluble biomarkers, proteomics, single-cell gene expression and immune repertoire analysis) to profile children with COVID-19 (n = 110) and MIS-C (n = 76), along with pediatric healthy controls (pHCs; n = 76). pCOVID-19 was characterized by robust type I interferon (IFN) responses, whereas prominent type II IFN-dependent and NF-kappa B-dependent signatures, matrisome activation and increased levels of circulating spike protein were detected in MIS-C, with no correlation with SARS-CoV-2 PCR status around the time of admission. Transient expansion of TRBV11-2 T cell clonotypes in MIS-C was associated with signatures of inflammation and T cell activation. The association of MIS-C with the combination of HLA A*02, B*35 and C*04 alleles suggests genetic susceptibility. MIS-C B cells showed higher mutation load than pCOVID-19 and pHC. These results identify distinct immunopathological signatures in pCOVID-19 and MIS-C that might help better define the pathophysiology of these disorders and guide therapy.

Published
2022

15. Development of a Model Foamy Viscous Fluid

Author

Vial C. and Narchi I.

Subjects
Chemical technology, TP1-1185, Energy industries. Energy policy. Fuel trade, HD9502-9502.5
Abstract

The objective is to develop a model viscous foamy fluid, i.e. below the very wet limit, the rheological and stability properties of which can be tuned. First, the method used for the preparation of foamy fluids is detailed, including process and formulation. Then, experimental results highlight that stable foamy fluids with a monomodal bubble size distribution can be prepared with a void fraction between 25% and 50% (v/v). Their viscoelastic properties under flow and low-strain oscillatory conditions are shown to result from the interplay between the formulation of the continuous phase, void fraction and bubble size. Their apparent viscosity can be described using the Cross equation and zero-shear Newtonian viscosity may be predicted by a Mooney equation up to a void fraction about 40%. The Cox-Merz and the Laun’s rules apply when the capillary number Ca is lower than 0.1. The upper limit of the zero-shear plateau region decreases when void fraction increases or bubble size decreases. In the shear-thinning region, shear stress varies with Ca1/2, as in wet foams with immobile surfaces. Finally, foamy fluids can be sheared up to Ca about 0.1 without impairing their microstructure. Their stability at rest achieves several hours and increases with void fraction due to compact packing constraints. These constitute, therefore, versatile model fluids to investigate the behaviour of foamy fluids below the very wet limit in process conditions.

Published
2013
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17. Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus

Author

Mario Calvo A., Grazielle Ribeiro E., Gregory J. Mertz, Marcela Ferrés G, Iris Delgado B, Elena Llop R, Raúl Riquelme O, Francisca Valdivieso R., Analia Cuiza V., Pablo A Vial C, Cecilia Vial C., and Gabriela M. Repetto L.

Subjects
Hantavirus pulmonary syndrome, medicine.medical_specialty, business.industry, education, Andes virus, Public Health, Environmental and Occupational Health, Disease, Infectious Diseases, Internal medicine, Severity of illness, Case fatality rate, Etiology, medicine, Hantavirus Infection, business, Hantavirus
Abstract

Background: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized. Aim: To evaluate sociodemographic factors as risk factors in severity of HCPS. Patients and Methods: Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died. Results: European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence. Conclusion: It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.

Published
2019

23. ULTRASONOGRAFIA DOPPLER COLOR EN EL DIAGNOSTICO DE MONONUCLEOSIS INFECCIOSA EN EL NIÑO

Author

Cristián García B, Roberto Oyanedel Q, Marcela Ferrés G, Dimitri Parra R, Rodrigo Parra R, Katia Abarca V, Pablo Vial C, TMs. Cecilia Weldt D, and Moira Egger P

Subjects
Mononucleosis infecciosa, Síndrome mononucleósico, US Doppler color, Virus Epstein-Barr, Color-Doppler ultrasonography, Infectious mononucleosis, Medical physics. Medical radiology. Nuclear medicine, R895-920, Medical technology, R855-855.5
Abstract

La mononucleosis infecciosa (MNI) es una enfermedad frecuente que afecta a niños y adolescentes y es causada por el virus Epstein-Barr. En la mayor parte de los casos (80%) se presenta como un cuadro agudo, caracterizado por fiebre, faringoamigdalitis y linfoadenopatías (forma anginosa). Con menor frecuencia, puede presentarse con poliadenopatías asociadas a fiebre baja y faringitis leve. La ultrasonografía (US) Doppler color ha demostrado ser de utilidad en el estudio de adenopatías en el niño y puede ser de utilidad en el diagnóstico de MNI. Objetivos: Describir los hallazgos de la US Doppler color en la MNI. Pacientes y Método: Se revisó en forma retrospectiva los antecedentes clínicos y estudios por imágenes de 10 niños con diagnóstico confirmado de MNI y en quienes se efectuó US como parte de su estudio. Resultados: El estudio US Doppler color de las adenopatías cervicales mostró hallazgos relativa-mente constantes en todos los pacientes: adenopatías bilaterales múltiples, ovaladas o semi-rredondeadas, con una razón largo-ancho < 2, hiper o isoecogénicas con respecto al músculo, sin necrosis o alteración de estructuras vecinas. Mostró además aumento de flujo vascular en todas las adenopatías. En los cuatro pacientes con US abdominal, se encontró hepatoesplenomegalia (3 pacientes) o esplenomegalia (1 paciente). En dos pacientes, el bazo mostraba un aspecto reticular y nodular fino, que podría ser secundario a la hiperplasia linfática reactiva, con compromiso fundamentalmente de la pulpa blanca, que ha sido descrita en el estudio histológico del bazo en pacientes con esta patología(9). Conclusiones: La MNI es una enferme-dad frecuente en el niño y en la mayoría de los casos el diagnóstico se sospecha clínicamente y se confirma con el estudio serológico específico. La US Doppler color muestra un aspecto relativamente constante en el estudio de las adenopatías periféricas en esta enfermedad y puede ser de utilidad en el diagnósticoInfectious mononucleosis is a common disease in children and in most cases, the diagnosis can be suspected with clinical findings alone and confirmed with serologic study. However, in some patients, clinical pesentation can be atypical. When presented with poliadenopahy, high-resolution color-Doppler ultrasonography (US) could be helpful in the differential diagnosis. We present the US characteristics of 10 children who presented with lymphadenopathy and had infectious mononucleosis, confirmed by serologic study. US findings were relatively constant in all patients. When sonographic findings are correlated with clinical and laboratory findings , a correct diagnosis can be suspected

Published
2004

24. INTEREST IN CD2, a global patient-centred study of long-term cervical dystonia treatment with botulinum toxin

Author

Misra, Vijay P., Colosimo, Carlo, Charles, David, Chung, Tae Mo, Maisonobe, Pascal, Om, Savary, Abdulnayef, A., Adatepe, N. U., Araujo Leite, M. A., Badarny, S., Bajenaru, O., Bares, M., Bejjani, P., Bergmans, B., Bhidayasiri, R., Bozic, H., Cardoso Costa, F. E., Carlstrom, C., Castelnovo, G., Chang, M. H., Chang, Y. Y., Coletti-Moja, M., Delvaux, V., Dioszhegy, P., Dogu, O., Duzynski, W., Ehler, E., Espinosa Sierra, L., Fabbrini, G., Ferreira, J., Ferreira Valadas, A., Foresti, C., Girlanda, P., Goh, K. J., Graca Velon, A., Grill, S., Gurevitch, T., Hadidi, M., Hamimed, M. A., Hamri, A., Harrower, T., Hassin, S., Hedera, P., Hernandez, J. F. J. G., Hernandez Franco, J., Ho, B., Ho, S. L., Hughes, A., Ilic, T., Inshasi, J. S., Ip, C. W., Jamieson, S., Jamora, R. D. G., Jech, R., Jeon, B. S., Kaminska, A., Karpova, M., Khasanova, D., Kim, J. M., Kim, J. W., Kok, C. Y., Korenko, A., Korv, J., Koussa, S., Kovacs, T., Kreisler, A., Krystkowiak, P., Kumthornthip, W., Lin, C. H., Lundin, F., Lus, G., Magalhaes, M., Masmoudi, A. N., Mercelis, R., Misbahuddin, A., Moebius, C., Mohammadi, B., Nazem, B., Ng, K., Nurlu, G., Nyberg, J., Nyholm, D., Ochudlo, S., Otruba, P., Pfister, R., Pirtosek, Z., Pokhabov, D., Quinones Aguilar, S., Quinones Canales, G., Raghev, S., Rickmann, H., Romano, M., Rosales, R. L., Rubanovits, I., Santilli, V., Schoels, L., Simonetta-Moreau, M., Simu, M. A., Sohn, Y. H., Soulayrol, S., Supe, I., Svetel, M., Sycha, T., Tan, E. K., Timerbaeva, S., Tokcaer, A. B., Trosch, R., Tugnoli, V., Tumas, V., van der Linden, C., Vetra, A., Vial, C., Vidry, E., Williams, D., Wimalaratna, S., Yiannikas, C., Misra, Vijay P., Colosimo, Carlo, Charles, David, Chung, Tae Mo, Maisonobe, Pascal, Om, Savary, Abdulnayef, A., Adatepe, N. U., Araujo Leite, M. A., Badarny, S., Bajenaru, O., Bares, M., Bejjani, P., Bergmans, B., Bhidayasiri, R., Bozic, H., Cardoso Costa, F. E., Carlstrom, C., Castelnovo, G., Chang, M. H., Chang, Y. Y., Coletti-Moja, M., Delvaux, V., Dioszhegy, P., Dogu, O., Duzynski, W., Ehler, E., Espinosa Sierra, L., Fabbrini, G., Ferreira, J., Ferreira Valadas, A., Foresti, C., Girlanda, P., Goh, K. J., Graca Velon, A., Grill, S., Gurevitch, T., Hadidi, M., Hamimed, M. A., Hamri, A., Harrower, T., Hassin, S., Hedera, P., Hernandez, J. F. J. G., Hernandez Franco, J., Ho, B., Ho, S. L., Hughes, A., Ilic, T., Inshasi, J. S., Ip, C. W., Jamieson, S., Jamora, R. D. G., Jech, R., Jeon, B. S., Kaminska, A., Karpova, M., Khasanova, D., Kim, J. M., Kim, J. W., Kok, C. Y., Korenko, A., Korv, J., Koussa, S., Kovacs, T., Kreisler, A., Krystkowiak, P., Kumthornthip, W., Lin, C. H., Lundin, F., Lus, G., Magalhaes, M., Masmoudi, A. N., Mercelis, R., Misbahuddin, A., Moebius, C., Mohammadi, B., Nazem, B., Ng, K., Nurlu, G., Nyberg, J., Nyholm, D., Ochudlo, S., Otruba, P., Pfister, R., Pirtosek, Z., Pokhabov, D., Quinones Aguilar, S., Quinones Canales, G., Raghev, S., Rickmann, H., Romano, M., Rosales, R. L., Rubanovits, I., Santilli, V., Schoels, L., Simonetta-Moreau, M., Simu, M. A., Sohn, Y. H., Soulayrol, S., Supe, I., Svetel, M., Sycha, T., Tan, E. K., Timerbaeva, S., Tokcaer, A. B., Trosch, R., Tugnoli, V., Tumas, V., van der Linden, C., Vetra, A., Vial, C., Vidry, E., Williams, D., Wimalaratna, S., and Yiannikas, C.

Subjects
Male, Neurology, SATISFACTION, International Cooperation, Cohort Studies, 0302 clinical medicine, QUALITY-OF-LIFE, Botulinum toxin, Observational study, Tremor, Epidemiology, 030212 general & internal medicine, Cervical dystonia, Botulinum Toxins, Type A, Torticollis, Neuroradiology, BLEPHAROSPASM, education.field_of_study, Original Communication, INTEREST IN CD2 study group, Middle Aged, Treatment Outcome, Neuromuscular Agents, Female, Life Sciences & Biomedicine, medicine.drug, Adult, medicine.medical_specialty, Population, Clinical Neurology, DIAGNOSIS, 03 medical and health sciences, Patient satisfaction, Neurology (clinical), Internal medicine, medicine, Humans, education, Aged, Science & Technology, Neurology & Neurosurgery, Electromyography, GUIDANCE, business.industry, 1103 Clinical Sciences, medicine.disease, NEUROTOXIN, REGISTRY, UPDATE, Neurosciences & Neurology, 1109 Neurosciences, business, 030217 neurology & neurosurgery
Abstract

Background Longitudinal cohort studies provide important information about the clinical effectiveness of an intervention in the routine clinical setting, and are an opportunity to understand how a population presents for treatment and is managed. Methods INTEREST IN CD2 (NCT01753349) is a prospective, international, 3-year, longitudinal, observational study following the course of adult idiopathic cervical dystonia (CD) treated with botulinum neurotoxin type A (BoNT-A). The primary objective is to document long-term patient satisfaction with BoNT-A treatment. Here we report baseline data. Results This analysis includes 1036 subjects (67.4% of subjects were female; mean age was 54.7 years old; mean TWSTRS Total score was 31.7). BoNT-A injections were usually given in line with BoNT-A prescribing information. The most commonly injected muscles were splenius capitis (87.3%), sternocleidomastoid (82.6%), trapezius (64.3%), levator scapulae (40.9%) and semispinalis capitis (26.9%); 35.5% of subjects were injected using a guidance technique. Most subjects (87.8%) had been previously treated with BoNT-A (median interval between last pre-study injection and study baseline was 4 months); of these 84.8% reported satisfaction with BoNT-A treatment at peak effect during their previous treatment cycle and 51.5% remained satisfied at the end of the treatment. Analyses by geographical region revealed heterogeneity in the clinical characteristics and BoNT-A injection practice of CD subjects presenting for routine treatment. Conclusions These baseline analyses provide sizeable data regarding the epidemiology and clinical presentation of CD, and demonstrate an international heterogeneity of clinical practice. Future longitudinal analyses of the full 3-year study will explore how these factors impact treatment satisfaction. Electronic supplementary material The online version of this article (10.1007/s00415-017-8698-2) contains supplementary material, which is available to authorized users.

Published
2017

28. Proposer du cheval au restaurant pour développer la demande

Author

Vial, C., Arnaud Lamy, Sandrine Costa, Maxime Sebbane, Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche de l'Institut Paul Bocuse, Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), SCHLEICH, Jean-Walter, Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
viande, offre, sociologie, [SHS.GESTION]Humanities and Social Sciences/Business administration, France, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, [SHS.GESTION] Humanities and Social Sciences/Business administration, marché, cheval de boucherie, [SHS.ECO]Humanities and Social Sciences/Economics and Finance
Abstract

National audience; Dans le contexte actuel de baisse continue de la consommation de viande chevaline en France, ces recherches s’intéressent aux freins et leviers mobilisables pour développer ce marché. Elles s’appuient sur une revue de littérature, le traitement de base de données préexistantes et des enquêtes qualitatives et quantitatives auprès du grand public et de chefs cuisiniers. Le premier levier identifié est lié à la visibilité et disponibilité de l’offre, afin d’accroitre la fréquence d’achat des consommateurs actuels. Un second levier s’appuie sur les caractéristiques de la viande de cheval qui peuvent lui permettre de répondre aux enjeux actuels de durabilité de de l’alimentation. Enfin, parmi les Français non-consommateurs de viande chevaline, 15% seraient prêts à consommer de la viande chevaline s’ils en avaient l’occasion, majoritairement chez des proches ou au restaurant. Développer la présence de viande chevaline en restauration commerciale apparait donc comme un moyen pertinent de familiariser de nouveaux consommateurs potentiels à ce produit. Ceci implique de pallier le manque de connaissances des chefs cuisiniers envers ce produit et le manque d’un répertoire de recettes.

Published
2021

32. Comparing Landsmót 2016 with other equestrian events: the case of the Alltech FEI World Equestrian Games™ 2014 in Normandy

Author

Vial, C., Barget, Eric, Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Pôle développement innovation et recherche, Institut Français du Cheval et de l'Equitation, Centre de Droit et d'Economie du Sport (CDES), Université de Limoges (UNILIM), Katherine Dashper, Guðrún Helgadóttir, Ingibjörg Sigurðardóttir, Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), SCHLEICH, Jean-Walter, and Katherine Dashper, Guðrún Helgadóttir, Ingibjörg Sigurðardóttir

Subjects
economic impact, tourist attractions, spectator events, social impact, horse riding, comparisons, regional development, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, sustainability, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, environmental impact
Abstract

International audience; This chapter aims to present the methodology and main results of a research focusing on the short-term economic, social and environmental impacts, as well as the long-term legacy of the Alltech FEI World Equestrian Games™ 2014 in Normandy (2014 WEG). Then it compares this event with Landsmót 2016, underlying that they have a lot in common behind their apparent differences. Finally, it can be concluded that equestrian events have various impacts for local areas that host them and participate in regional development. In order to optimize that, actions have to be implemented with sustainability in mind, taking into account economic, social and environmental aspects.

Published
2021

33. ONF’s arboreta of national interest

Author

Lamant, Thierry, Bénard, L., Berthon, S., Bimont, S., Blaison, L., Castagnio, J.P., Diaz, E., Fauveau, M., Granet, A.M., Guardia, G., Le Rol, J.P., Levannier, P., Loho, P., Mazoyer, P., Monzo, G., Pasqualini, M., Perrette, N., Savajols, G., Simonnet, F., Triolo, J., Vandaele, J., Vial, C., Musch, Brigitte, and musch, brigitte

Subjects
[SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDE.MCG] Environmental Sciences/Global Changes, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, [SDV.SA.SF] Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, [SDV.BV.BOT] Life Sciences [q-bio]/Vegetal Biology/Botanics
Published
2021

34. ODEFI pour connaître les atouts verts des équidés en Europe !

Author

Rzekęć, Agata, Vial, C., SCHLEICH, Jean-Walter, Institut Français du Cheval et de L'équitation (IFCE), Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Europe, [SDV.SA.AEP] Life Sciences [q-bio]/Agricultural sciences/Agriculture, economy and politics, [SDV.SA.AEP]Life Sciences [q-bio]/Agricultural sciences/Agriculture, economy and politics, banque de données, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, environnement, politique agricole
Abstract

National audience; Les équidés, de par leur nature et leur place au sein de la société, ont un rôle à jouer dans le contexte de prise de conscience écologique actuel. Ils sont présentés dans ce projet comme acteurs multifonctionnels, rendant des services environnementaux. Ces derniers sont nommés « atouts verts ». Afin de centraliser les données disponibles à ce sujet au sein des différents pays Européens, l’outil ODEFI (Outil de collecte de Données Environnementales des Filières équines Internationales) a été développé. Il donne lieu à une base de données permettant d’améliorer notre connaissance sur les atouts verts des filières équines européennes. En 2020-2021, huit pays ont été enquêtés (France, Belgique, Suède, Croatie, Pologne, Slovénie, Roumanie et Allemagne) au travers de 58 indicateurs.Une grande hétérogénéité entre pays apparait concernant la disponibilité des données. Néanmoins, une première typologie peut être dessinée avec trois groupes de pays : (1) le cheval, outil agricole en élevage extensif ; (2) le cheval sportif ou de loisir, associé à un regain d’intérêt pour sa force motrice ; (3) un intermédiaire entre les deux situations précédentes. La collecte se poursuit auprès d’autres pays afin d’affiner les résultats et de dresser un panorama des atouts verts européens le plus complet possible.

Published
2021

39. Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus

Author

Vial C.,Cecilia, Valdivieso R.,Francisca, Cuiza V.,Analía, Delgado B.,Iris, Ribeiro E.,Grazielle, Llop R.,Elena, Ferrés G.,Marcela, Repetto L.,Gabriela M., Riquelme O.,Raúl, Rioseco Z.,M. Luisa, Calvo A.,Mario, Mertz,Gregory, and Vial C.,Pablo A.

Subjects
susceptibilidad étnica, síndrome cardiopulmonar por hantavirus, infección por hantavirus, hantavirus Andes, Hantavirus
Abstract

Resumen Introducción: El síndrome cardiopulmonar por hantavirus (SCPH) es causado en Chile y en el sur de Argentina por el Andes hantavirus (ANDV), el que es endémico en esta zona. La enfermedad causada por ANDV produce un aumento de permeabilidad vascular y filtración de plasma con una alta tasa de letalidad (35%), debido principalmente a insuficiencia respiratoria por edema pulmonar y al desarrollo en los casos graves de compromiso miocárdico, hipoperfusión y shock. Aunque se sabe que los factores socio-demográficos del hospedero pueden influir en el curso y el resultado de la enfermedad, estos no se han caracterizado previamente en la población chilena. Objetivo: Evaluar la relación entre los factores socio-demográficos y la gravedad del SCPH. Pacientes y Métodos: Período de análisis 2004-20013, pacientes atendidos en ocho centros colaboradores, diagnóstico etiológico serológico o por biología molecular, se comparan SCPH leve y grave. Se analizaron 139 pacientes chilenos, 64 (46%) con enfermedad grave, entre los cuales 12 murieron (19%). Resultados: La etnia europea tuvo un riesgo 5,1 veces mayor de desarrollar un SCPH grave que la etnia amerindia, gravedad mayor que también se asoció a una residencia urbana. Conclusiones: Se observó una asociación estadísticamente significativa entre etnia, lugar de residencia y evolución de SCPH. Se discuten hipótesis que expliquen estos hallazgos.

Published
2019

40. Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus

Author

Vial C., Cecilia, Valdivieso R., Francisca, Cuiza V., Analía, Delgado B., Iris, Ribeiro E., Grazielle, Llop R., Elena, Ferrés G., Marcela, Repetto L., Gabriela M., Riquelme O., Raúl, Rioseco Z., M. Luisa, Calvo A., Mario, Mertz, Gregory, and Vial C., Pablo A.

Subjects
susceptibilidad étnica, hantavirus infection, Andes hantavirus, síndrome cardiopulmonar por hantavirus, ethnic susceptibility, infección por hantavirus, hantavirus pulmonary syndrome, hantavirus Andes, Hantavirus
Abstract

Resumen Introducción: El síndrome cardiopulmonar por hantavirus (SCPH) es causado en Chile y en el sur de Argentina por el Andes hantavirus (ANDV), el que es endémico en esta zona. La enfermedad causada por ANDV produce un aumento de permeabilidad vascular y filtración de plasma con una alta tasa de letalidad (35%), debido principalmente a insuficiencia respiratoria por edema pulmonar y al desarrollo en los casos graves de compromiso miocárdico, hipoperfusión y shock. Aunque se sabe que los factores socio-demográficos del hospedero pueden influir en el curso y el resultado de la enfermedad, estos no se han caracterizado previamente en la población chilena. Objetivo: Evaluar la relación entre los factores socio-demográficos y la gravedad del SCPH. Pacientes y Métodos: Período de análisis 2004-20013, pacientes atendidos en ocho centros colaboradores, diagnóstico etiológico serológico o por biología molecular, se comparan SCPH leve y grave. Se analizaron 139 pacientes chilenos, 64 (46%) con enfermedad grave, entre los cuales 12 murieron (19%). Resultados: La etnia europea tuvo un riesgo 5,1 veces mayor de desarrollar un SCPH grave que la etnia amerindia, gravedad mayor que también se asoció a una residencia urbana. Conclusiones: Se observó una asociación estadísticamente significativa entre etnia, lugar de residencia y evolución de SCPH. Se discuten hipótesis que expliquen estos hallazgos. Background: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized. Aim: To evaluate sociodemographic factors as risk factors in severity of HCPS. Patients and Methods: Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died. Results: European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence. Conclusion: It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.

Published
2019

41. [Sociodemographic risk factors of hantavirus cardiopulmonary syndrome]

Author

Cecilia, Vial C, Francisca, Valdivieso R, Analía, Cuiza V, Iris, Delgado B, Grazielle, Ribeiro E, Elena, Llop R, Marcela, Ferrés G, Gabriela M, Repetto L, Raúl, Riquelme O, M Luisa, Rioseco Z, Mario, Calvo A, Gregory, Mertz, and Pablo A, Vial C

Subjects
Adult, Male, Adolescent, Hantavirus Pulmonary Syndrome, Middle Aged, Severity of Illness Index, Young Adult, Socioeconomic Factors, Risk Factors, Humans, Female, Chile, Child, Aged
Abstract

Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized.To evaluate sociodemographic factors as risk factors in severity of HCPS.Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died.European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence.It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.

Published
2019

42. Is the early-onset torsion dystonia (EOTD) linked to TOR1A gene as frequent as expected in France?

Author

Frédéric, M. Y., Clot, F., Cif, L., Blanchard, A., Dürr, A., Vuillaume, I., Lesca, G., Kreisler, A., Davin, C., Besnard, T., Rousset, F., Thorel, D., Saquet, C., Mechin, D., Ozelius, L., Agid, Y., Barroso, B., Chabrol, B., Chan, V., Clanet, M., Coubes, C., Destee, A., Nguyen, K., Vial, C., Vidailhet, M., Xie, J., Sablonniere, B., Calender, A., Brice, A., Roubertie, A., Coubes, P., Claustres, M., Tuffery-Giraud, S., and Collod-Beroud, G.

Published
2008
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44. Co-creation between consumers or with firms: determinants, consequences and components of value consumption in services

Author

Eslan, Camille, Costa, Sandrine, Vial, C., Fédération Française d'Equitation (FFE), Institut Français du Cheval et de L'équitation (IFCE), Marchés, Organisations, Institutions et Stratégies d'Acteurs (UMR MOISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Value co-creation, Consumption, Services, [SHS.GESTION]Humanities and Social Sciences/Business administration, [SHS.ECO]Humanities and Social Sciences/Economics and Finance
Abstract

International audience; In the context of leisure sports, many people are leaving sporting clubs to self- organize (Chillet 2019), alone or with other consumers (Heinonen, Campbell, and Ferguson 2019). This poses a problem for clubs and sport federations as it leads to a decrease in members’ number (Eslan, Vial, Costa and Rollet 2019). This presentation will review the literature on value co- creation (VCC) / prosumption to understand (i) what determines consumer participation in the produc- tion process and (ii) whether the service offering of a firm using value co-creation could substitute for consumer self-organization. We first present the determinants and consequences of consumer participa- tion in a co-creation process with a business or among consumers. This part highlights the crucial role of value in customer decisions, introducing the value creation process described in the second part. Thirdly, we propose an integrative approach of value co-creation in the choice of service production applied to self-organized activities. Prosumption, the act of consuming and producing, allows con- sumers to personalize their products or services. If this process is carried out in relation with several actors (professionals, consumer groups, organizations or individuals), we speak of value co- creation, with personalization often mainly managed by companies. Leclercq, Hammedi, and Poncin (2016) defines co-creation as “a joint process during which value is reciprocally created for each actor (individu- als, organizations or networks)” to interact and exchange resources. In line with Heinonen, Jaakkola, and Neganova (2018), we posit that C to C co- creation depends on the value inherent in the interaction between the customer and the provider, but also emerging from the interactions between customers. Prior research has shown the importance of motivations for en- gaging in prosumption. Its antecedents are rooted in either the cus- tomer’s buying experience or the decision-making process. Carrying out a project of prosumption requires knowledge, skills, community seeking and time (Wolf, Albinsson, and Becker 2015). Heinonen et al. (2018) show a range of drivers of C to C interactions induced by firms, situations or customers (motivations), these are either for dif- ferent social or personal benefits. Benefits are thus emotional value or reinforcement of affective (i.e., emotional) and network (i.e., so- cial) values for focal clients through the playful and ludic behav- iors of other clients (Kim, Byon, and Baek 2019). In sport, C to C co-creation studies show that the presence of interactions motivates participants, thereby enhancing consumer experience (Kolyperas, Maglaras, and Sparks 2019). Moreover, willingness to participate to future co-creation activities depends on past experience, thus on the consequences of the process influenced by moderators such as trust or demographic determinants. These moderators act either before, during or after VCC process. Furthermore, in line with Aurier, Evrard, and N’Goala (2004), we integrate overall perceived value as a consequence of VCC pro- cess. The sacrifices made and the benefits perceived constitute over- all perceived value. It goes beyond the profit to cost ratio shown by Xie, Bagozzi, and Troye (2008), which is not only an economic benefit or cost. However, if this overall value is in favour of sac- rifice, consumers will turn to outsourcing rather than prosumption. The relationship between value creation and process outcomes then underlines the central role of value in the consumer’s decision to par- ticipate in production, especially under the influence of overall per- ceived value, as some components of value seem more decisive than others in consumer participation. The absence of certain components may lead to the co-creation process being halted. Our position herein is to analyze value creation resulting from consumer interactions and components of this value as preferential judgments. We propose an integrative picture of the different dimensions of value based on Holbrook (2002) and Aurier et al. (2004). The above criteria have thus resulted in a typology that breaks down the value into four main components: instrumental, hedonic, social and spiritual value. We enrich the spiritual value component with holistic value (Lai 1995) which is the perceptual benefits that depends on how compatible or coherent this consumption is perceived by the consumer. Furthermore, we support Medberg and Heinonen (2014) research on the influence of invisible values. These authors consider that value creation emerges either by the companies, in the relation- ship between companies and customers, or by the customer alone. Thus, spiritual value also refers to shared moral value as the adequa- cy between customers’ own moral standards and the standards of the other stakeholder. Corneloup (2016) in climbing activity shows an opposition of practitioners according to their practice style. Califor- nian-style practitioners focused on their relationship with nature and do not wish a more competitive form motivated by quick climbing on an artificial wall. Moreover, responsibility value is defined as the firm’s “practice of responsibility and integrity towards its custom- ers”. Both values relate indirectly to how the companies operate, then they can be integrated as intrinsic others-orientated approach. For heritage value, based on the history of the customer and its rela- tives with the company, we consider it more as social value, as heri- tage exclusively depends on consumption experience of the customer and its relatives. Like the relationship value, defined as a long-term relationship between actors, these values are based specifically on the clients’ own logic. This critical qualitative analysis of VCC literature tries to un- derstand why consumers do engage in VCC with companies or in C to C. The analysis of value components highlights invisible values that may explain why consumers prefer to co-create with others than with firms. Indeed, when consumers do not find all value dimensions they are looking for in the professional structures, then they drop out of professional structures. Future researches should focus on supply and demand adequacy to restructure service offer for companies, and confirm the integrative approach of value in the analysis of consum- ers’ participation to co- creation. Firms have leverage if they take into account the value dimensions in the co- creation process in order to recapture consumers organized in C to C, but also, on a critical perspective, to find out what occurs when consumers are not able to co-create, do not want or see value in the process.

Published
2020

48. P2[X.sub.1] receptors mediate sympathetic postjunctional [Ca.sup.2+] transients in mesenteric small arteries

Author

Lamont, Christine, Vial, C., Evans, R.J., and Wier, W.G.

Subjects
Adenosine triphosphate -- Research, Neurotransmitters -- Research, Smooth muscle -- Research, Vasoconstriction -- Research, Biological sciences
Abstract

Brief, spatially localized [Ca.sup.2+] transients occur in the smooth muscle adjacent to perivascular nerves of small arteries during neurogenic contractions. We named these 'junctional [Ca.sup.2+] transients' (jCaTs) and postulated that they arose from [Ca.sup.2+] entering smooth muscle cells through P2[X.sub.1] receptors activated by neurally released ATP. Nevertheless, the lack of potent, subtype-selective P2X-receptor antagonists made determining the exact molecular identity of the channels difficult. Here we used small, pressurized mesenteric arteries from P2[X.sub.1]-receptor-deficient mice (KO) to test the hypothesis that jCaTs arise from [Ca.sup.2+] entering the smooth muscle cell via P2[X.sub.1] receptors. In wild-type (WT) arteries, confocal microscopy of fluo-4 fluorescence during electrical field stimulation (EFS) of perivascular sympathetic nerves revealed jCaTs in the smooth muscle cells adjacent to the perivascular nerves, similar to those reported previously in rat arteries, and [alpha]-latrotoxin (2.5 nM) markedly increased the frequency of 'spontaneous' jCaTs. In the KO arteries, however, neither EFS nor [alpha]-latrotoxin elicited any jCaTs. A potent P2X-receptor agonist, [alpha],[beta]-methylene ATP (10.0 [micro]M), elicited strong contractions and increased intracellular [Ca.sup.2+] concentration in WT arteries but elicited neither in KO arteries. A biphasic vasoconstriction in response to EFS was observed in WT arteries. In KO arteries, however, the initial rapid, transient component of the biphasic vasoconstriction was absent. The data support the hypothesis that jCaTs represent [Ca.sup.2+] that enters the smooth muscle cells through P2[X.sub.1] receptors activated by neurally released ATP and that this [Ca.sup.2+] is involved in the initial rapid component of the sympathetic neurogenic contraction. arterial smooth muscle; vasoconstriction; neurotransmitters; adrenergic and adenosine 5'-triphosphate

Published
2006

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