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4. Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients: A literature review and a case series of 17 patients from 3 studies

Author

Ruan, Can-Jun, Olmos, Ismael, Ricciardi, Carina, Schoretsanitis, Georgios, Vincent, Philippe D., Anıl Yağcıoğlu, A. Elif, Eap, Chin B., Baptista, Trino, Clark, Scott R., Fernandez-Egea, Emilio, Kim, Se Hyun, Lane, Hsien-Yuan, Leung, Jonathan, Maroñas Amigo, Olalla, Motuca, Mariano, Every-Palmer, Susanna, Procyshyn, Ric M., Rohde, Christopher, Suhas, Satish, Schulte, Peter F.J., Spina, Edoardo, Takeuchi, Hiroyoshi, Verdoux, Hélène, Correll, Christoph U., Molden, Espen, De Las Cuevas, Carlos, and de Leon, Jose

Published
2024
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5. Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition

Author

Schoretsanitis, Georgios, Anıl Yağcıoğlu, A. Elif, Ruan, Can-Jun, Eap, Chin B., Molden, Espen, Baptista, Trino, Clark, Scott R., Fernandez-Egea, Emilio, Kim, Se Hyun, Lane, Hsien-Yuan, Leung, Jonathan, Maroñas Amigo, Olalla, Motuca, Mariano, Olmos, Ismael, Every-Palmer, Susanna, Procyshyn, Ric M., Rohde, Christopher, Satish, Suhas, Schulte, Peter F.J., Spina, Edoardo, Takeuchi, Hiroyoshi, Verdoux, Hélène, Correll, Christoph U., and de Leon, Jose

Published
2024
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7. Guía internacional para una dosificación más segura de la clozapina en adultos mediante el uso de 6 titulaciones personalizadas de dosis basados en la etnicidad, la proteína C reactiva y los niveles de clozapina

Author

de Leon, Jose, Schoretsanitis, Georgios, Smith, Robert L., Molden, Espen, Solismaa, Anssi, Seppälä, Niko, Kopeček, Miloslav, Švancer, Patrik, Olmos, Ismael, Ricciardi, Carina, Iglesias-Garcia, Celso, Iglesias-Alonso, Ana, Spina, Edoardo, Ruan, Can-Jun, Wang, Chuan-Yue, Wang, Gang, Tang, Yi-Lang, Lin, Shih-Ku, Lane, Hsien-Yuan, Kim, Yong Sik, Kim, Se Hyun, Rajkumar, Anto P., González-Esquivel, Dinora F., Jung-Cook, Helgi, Baptista, Trino, Rohde, Christopher, Nielsen, Jimmi, Verdoux, Hélène, Quiles, Clelia, Sanz, Emilio J., De las Cuevas, Carlos, Cohen, Dan, Schulte, Peter F.J., Ertuğrul, Aygün, Anıl Yağcıoğlu, A. Elif, Chopra, Nitin, McCollum, Betsy, Shelton, Charles, Cotes, Robert O., Kaithi, Arun R., Kane, John M., Farooq, Saeed, Ng, Chee H., Bilbily, John, Hiemke, Christoph, López-Jaramillo, Carlos, McGrane, Ian, Lana, Fernando, Eap, Chin B., Arrojo-Romero, Manuel, Rădulescu, Flavian Ştefan, Seifritz, Erich, Every-Palmer, Susanna, Bousman, Chad A., Bebawi, Emmanuel, Bhattacharya, Rahul, Kelly, Deanna L., Otsuka, Yuji, Lazary, Judit, Torres, Rafael, Yecora, Agustin, Motuca, Mariano, Chan, Sherry Kit Wa, Zolezzi, Monica, Ouanes, Sami, De Berardis, Domenico, Grover, Sandeep, Procyshyn, Ric M., Adebayo, Richard A., Kirilochev, Oleg O., Soloviev, Andrey, Fountoulakis, Konstantinos N., Wilkowska, Alina, Cubała, Wiesław Jerzy, Ayub, Muhammad, Silva, Alzira, Bonelli, Raphael M., Villagrán-Moreno, José María, Crespo-Facorro, Benedicto, Temmingh, Henk, Decloedt, Eric, Pedro, Maria Rosel, Takeuchi, Hiroyoshi, Tsukahara, Masaru, Gründer, Gerhard, Sagud, Marina, Celofiga, Andreja, Ignjatovic Ristic, Dragana, Ortiz, Bruno Bertolucci, Elkis, Helio, Pacheco Palha, António José, Llerena, Adrián, Fernandez-Egea, Emilio, Siskind, Dan, Weizman, Abraham, Masmoudi, Rim, Mohd Saffian, Shamin, Leung, Jonathan G., Buckley, Peter F., Marder, Stephen R., Citrome, Leslie, Freudenreich, Oliver, Correll, Christoph U., and Müller, Daniel J.

Published
2023
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16. International trends in antipsychotic use: A study in 16 countries, 2005–2014

Author

Hálfdánarson, Óskar, Zoëga, Helga, Aagaard, Lise, Bernardo, Miquel, Brandt, Lena, Fusté, Anna Coma, Furu, Kari, Garuoliené, Kristina, Hoffmann, Falk, Huybrechts, Krista F., Kalverdijk, Luuk J., Kawakami, Koji, Kieler, Helle, Kinoshita, Takuya, Litchfield, Melisa, López, Soffy C., Machado-Alba, Jorge E., Machado-Duque, Manuel E., Mahesri, Mufaddal, Nishtala, Prasad S., Pearson, Sallie-Anne, Reutfors, Johan, Saastamoinen, Leena K., Sato, Izumi, Schuiling-Veninga, Catharina C.M., Shyu, Yu-Chiau, Skurtveit, Svetlana, Verdoux, Hélène, Wang, Liang-Jen, Yahni, Corinne Zara, and Bachmann, Christian J.

Published
2017
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23. Being parent is associated with suicidal history in people with serious mental illness enrolled in psychiatric rehabilitation

Author

DUBREUCQ, M., Plasse, J., Gabayet, F., Blanc, O., Chereau, I., CERVELLO, S., COUHET, G., Demily, C., GUILLARD-BOUHET, N., GOUACHE, B., Jaafari, N., Legrand, G., LEGROS-LAFARGE, E., MORA, G., Pommier, R., Quiles, Clelia, VERDOUX, Helene, Massoubre, C., NETWORK, R. EHABAse, FRANCK, N., Dubreucq, J., Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Université de Poitiers

Subjects
Male, Parents, medicine.medical_specialty, Multivariate analysis, education.educational_degree, Psychological intervention, Mothers, Psychiatric rehabilitation, Suicidal Ideation, Fathers, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Recovery, Humans, Medicine, Child, Psychiatry, education, Biological Psychiatry, Parenting, Suicide attempt, business.industry, Mental Disorders, Mental illness, medicine.disease, Serious mental illness, 3. Good health, 030227 psychiatry, Suicide, Psychiatry and Mental health, Cohort, Quality of Life, Marital status, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, 030217 neurology & neurosurgery
Abstract

International audience; Parenting is a central life experience that could promote recovery in people with Serious Mental Illness (SMI). It could also be challenging for parents with SMI and result in poor recovery-related outcomes. Parenting is often overlooked in psychiatric rehabilitation. The objectives of the present study were to identify the characteristics and needs for care of mothers and fathers with SMI enrolled in a multicentric non-selected psychiatric rehabilitation SMI sample. We consecutively recruited 1436 outpatients from the French National Centers of Reference for Psychiatric Rehabilitation cohort (REHABase). The evaluation included standardized scales for clinical severity, psychosocial function, quality of life and satisfaction with life, wellbeing, personal recovery and a broad cognitive battery. We found that parenting was associated to suicidal history in mothers and fathers with SMI. In the multivariate analysis, being mother was best explained by insight (p

Published
2021

25. Specific vs general cognitive remediation for executive functioning in schizophrenia: A multicenter randomized trial

Author

Franck, Nicolas, Duboc, Chloé, Sundby, Charlotte, Amado, Isabelle, Wykes, Til, Demily, Caroline, Launay, Corinne, Le Roy, Vincent, Bloch, Pascal, Willard, Dominique, Todd, Aurélia, Petitjean, François, Foullu, Sandrine, Briant, Patrick, Grillon, Marie-Laure, Deppen, Patricia, Verdoux, Hélène, Bralet, Marie-Cécile, Januel, Dominique, Riche, Benjamin, Roy, Pascal, and Vianin, Pascal

Published
2013
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28. An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels

Author

de Leon, Jose, Schoretsanitis, Georgios, Smith, Robert L., Molden, Espen, Solismaa, Anssi, Seppala, Niko, Kopecek, Miloslav, Svancer, Patrik, Olmos, Ismael, Ricciardi, Carina, Iglesias-Garcia, Celso, Iglesias-Alonso, Ana, Spina, Edoardo, Ruan, Can-Jun, Wang, Chuan-Yue, Wang, Gang, Tang, Yi-Lang, Lin, Shih-Ku, Lane, Hsien-Yuan, Kim, Yong Sik, Kim, Se Hyun, Rajkumar, Anto P., Gonzalez-Esquivel, Dinora F., Jung-Cook, Helgi, Baptista, Trino, Rohde, Christopher, Nielsen, Jimmi, Verdoux, Helene, Quiles, Clelia, Sanz, Emilio J., De las Cuevas, Carlos, Cohen, Dan, Schulte, Peter F. J., Ertugrul, Aygun, Chopra, Nitin, McCollum, Betsy, Shelton, Charles, Cotes, Robert O., Kaithi, Arun R., Kane, John M., Farooq, Saeed, Ng, Chee H., Bilbily, John, Hiemke, Christoph, Lopez-Jaramillo, Carlos, McGrane, Ian, Lana, Fernando, Eap, Chin B., Arrojo-Romero, Manuel, Seifritz, Erich, Every-Palmer, Susanna, Bousman, Chad A., Bebawi, Emmanuel, Bhattacharya, Rahul, Kelly, Deanna L., Otsuka, Yuji, Lazary, Judit, Torres, Rafael, Yecora, Agustin, Motuca, Mariano, Chan, Sherry K. W., Zolezzi, Monica, Ouanes, Sami, De Berardis, Domenico, Grover, Sandeep, Procyshyn, Ric M., Adebayo, Richard A., Kirilochev, Oleg O., Soloviev, Andrey, Fountoulakis, Konstantinos N., Wilkowska, Alina, Ayub, Muhammad, Silva, Alzira, Bonelli, Raphael M., Villagran-Moreno, Jose M., Crespo-Facorro, Benedicto, Temmingh, Henk, Decloedt, Eric, Pedro, Maria R., Takeuchi, Hiroyoshi, Tsukahara, Masaru, Gruender, Gerhard, Sagud, Marina, Celofiga, Andreja, Ristic, Dragana Ignjatovic, Ortiz, Bruno B., Elkis, Helio, Palha, Antonio J. Pacheco, LLerena, Adrian, Fernandez-Egea, Emilio, Siskind, Dan, Weizman, Abraham, Masmoudi, Rim, Saffian, Shamin Mohd, Leung, Jonathan G., Buckley, Peter F., Marder, Stephen R., Citrome, Leslie, Freudenreich, Oliver, Correll, Christoph U., Muller, Daniel J., Anil Yagcioglu, A. Elif, Radulescu, Flavian S., Cubala, Wieslaw J., de Leon, Jose, Schoretsanitis, Georgios, Smith, Robert L., Molden, Espen, Solismaa, Anssi, Seppala, Niko, Kopecek, Miloslav, Svancer, Patrik, Olmos, Ismael, Ricciardi, Carina, Iglesias-Garcia, Celso, Iglesias-Alonso, Ana, Spina, Edoardo, Ruan, Can-Jun, Wang, Chuan-Yue, Wang, Gang, Tang, Yi-Lang, Lin, Shih-Ku, Lane, Hsien-Yuan, Kim, Yong Sik, Kim, Se Hyun, Rajkumar, Anto P., Gonzalez-Esquivel, Dinora F., Jung-Cook, Helgi, Baptista, Trino, Rohde, Christopher, Nielsen, Jimmi, Verdoux, Helene, Quiles, Clelia, Sanz, Emilio J., De las Cuevas, Carlos, Cohen, Dan, Schulte, Peter F. J., Ertugrul, Aygun, Chopra, Nitin, McCollum, Betsy, Shelton, Charles, Cotes, Robert O., Kaithi, Arun R., Kane, John M., Farooq, Saeed, Ng, Chee H., Bilbily, John, Hiemke, Christoph, Lopez-Jaramillo, Carlos, McGrane, Ian, Lana, Fernando, Eap, Chin B., Arrojo-Romero, Manuel, Seifritz, Erich, Every-Palmer, Susanna, Bousman, Chad A., Bebawi, Emmanuel, Bhattacharya, Rahul, Kelly, Deanna L., Otsuka, Yuji, Lazary, Judit, Torres, Rafael, Yecora, Agustin, Motuca, Mariano, Chan, Sherry K. W., Zolezzi, Monica, Ouanes, Sami, De Berardis, Domenico, Grover, Sandeep, Procyshyn, Ric M., Adebayo, Richard A., Kirilochev, Oleg O., Soloviev, Andrey, Fountoulakis, Konstantinos N., Wilkowska, Alina, Ayub, Muhammad, Silva, Alzira, Bonelli, Raphael M., Villagran-Moreno, Jose M., Crespo-Facorro, Benedicto, Temmingh, Henk, Decloedt, Eric, Pedro, Maria R., Takeuchi, Hiroyoshi, Tsukahara, Masaru, Gruender, Gerhard, Sagud, Marina, Celofiga, Andreja, Ristic, Dragana Ignjatovic, Ortiz, Bruno B., Elkis, Helio, Palha, Antonio J. Pacheco, LLerena, Adrian, Fernandez-Egea, Emilio, Siskind, Dan, Weizman, Abraham, Masmoudi, Rim, Saffian, Shamin Mohd, Leung, Jonathan G., Buckley, Peter F., Marder, Stephen R., Citrome, Leslie, Freudenreich, Oliver, Correll, Christoph U., Muller, Daniel J., Anil Yagcioglu, A. Elif, Radulescu, Flavian S., and Cubala, Wieslaw J.

Abstract

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and it produces four times higher worldwide pneumonia mortality than that by agranulocytosis or myocarditis. For trough steady-state clozapine serum concentrations, the therapeutic reference range is narrow, from 350 to 600 ng/mL with the potential for toxicity and ADRs as concentrations increase. Clozapine is mainly metabolized by CYP1A2 (female non-smokers, the lowest dose; male smokers, the highest dose). Poor metabolizer status through phenotypic conversion is associated with co-prescription of inhibitors (including oral contraceptives and valproate), obesity, or inflammation with C-reactive protein (CRP) elevations. The Asian population (Pakistan to Japan) or the Americas' original inhabitants have lower CYP1A2 activity and require lower clozapine doses to reach concentrations of 350 ng/mL. In the US, daily doses of 300-600 mg/day are recommended. Slow personalized titration may prevent early ADRs (including syncope, myocarditis, and pneumonia). This guideline defines six personalized titration schedules for inpatients: 1) ancestry from Asia or the original people from the Americas with lower metabolism (obesity or valproate) needing minimum therapeutic dosages of 75-150 mg/day, 2) ancestry from Asia or the original people from the Americas with average metabolism needing 175-300 mg/day, 3) European/Western Asian ancestry with lower metabolism (obesity or valproate) needing 100-200 mg/day, 4) European/Western Asian ancestry with average metabolism needing 250-400 mg/day, 5) in the US with ancestries other than from Asia or the original people from the Americas with lower clozapine metabolism (obesity or valproate) needing 150-300 mg/day, and 6) in the US with ancestries other than from Asia or the original people fr

Published
2022

37. J Psychiatry Neurosci

Author

SISKIND, D., HONER, W. G., Clark, S., CORRELL, C. U., Hasan, A., HOWES, O., KANE, J. M., KELLY, D. L., LAITMAN, R., Lee, J., MACCABE, J. H., MYLES, N., Nielsen, J., SCHULTE, P. F., Taylor, D., VERDOUX, Helene, Wheeler, A., FREUDENREICH, O., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
PharmacoEpi-Drugs, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Published
2020

38. Life-threatening adverse drug reactions at admission to medical intensive care: a prospective study in a teaching hospital

Author

Grenouillet-Delacre, Marieke, Verdoux, Helene, Moore, Nicholas, Haramburu, Francoise, Miremont-Salame, Ghada, Etienne, Gabriel, Robinson, Philip, Gruson, Didier, Hilbert, Gilles, Gabinski, Claude, Begaud, Bernard, and Molimard, Mathieu

Subjects
Drugs -- Health aspects -- Research, Hospital patients -- Health aspects -- Research, Health care industry
Abstract

Objective: To assess the characteristics of life-threatening adverse drug reactions in patients admitted to medical intensive care unit and to define those that could facilitate early identification. Design: A prospective 6-month observational study. Patients: Of the 436 admissions to the teaching hospital medical intensive care unit, all patients aged over 15 years and who had received documented drug treatment were included (n = 405). Measurements: Characteristics of patients [age, gender, underlying diseases, organ failure(s), drugs taken, Severity Acute Physiologic Score II, length of stay, outcome at discharge] were prospectively collected using a standardised questionnaire. A panel of experts assessed putative serious adverse drug reaction(s) for each drug taken and each organ failure at admission by using a standardised causality assessment method. Characteristics of patients with and without serious adverse drug reactions at admission were compared using univariate and then stepwise descending multivariate logistic regression. Results: Of the 405 patients included, 111 (27.4%) presented an adverse drug reaction leading to organ failure. In 48% of cases adverse drug reactions were preventable, 23% were undiagnosed and 19% contributed to death. Age over 75 years [odds ratio (OR) 2.25; 95% confidence interval (CI) 1.15-4.38; p = 0.02], having more than three drugs (OR 6.90; 95% CI 1.44-33.00; p = 0.02) and a diagnosis of haematological malignancy (OR 6.19; 95% CI 2.07-18.53; p = 0.001) were independently associated with serious adverse drug reactions. Conclusions: Preventable life-threatening adverse drug reactions were frequently involved in organ failure at admission to medical intensive care; many of them had not been identified. Keywords Serious adverse drug reaction * Organ failure * Intensive care unit, Introduction Adverse drug reactions (ADRs) are frequent and can occur during hospitalisation leading to either hospitalisation or prolongation of stay [1, 2]. Serious ADRs are fatal in 5% of cases, [...]

Published
2007
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39. Consensus statement on the use of clozapine during the COVID-19 pandemic

Author

Siskind, Dan, Honer, William G, Clark, Scott, Correll, Christoph U, Hasan, Alkomiet, Howes, Oliver, Kane, John M, Kelly, Deanna L, Laitman, Robert, Lee, Jimmy, MacCabe, James H, Myles, Nick, Nielsen, Jimmi, Schulte, Peter F, Taylor, David, Verdoux, Helene, Wheeler, Amanda, Freudenreich, Oliver, Siskind, Dan, Honer, William G, Clark, Scott, Correll, Christoph U, Hasan, Alkomiet, Howes, Oliver, Kane, John M, Kelly, Deanna L, Laitman, Robert, Lee, Jimmy, MacCabe, James H, Myles, Nick, Nielsen, Jimmi, Schulte, Peter F, Taylor, David, Verdoux, Helene, Wheeler, Amanda, and Freudenreich, Oliver

Published
2020

40. Clozapine and COVID-19:The authors respond

Author

Siskind, Dan, Honer, William G, Clark, Scott, Correll, Christoph U, Hasan, Alkomiet, Howes, Oliver, Kane, John M, Kelly, Deanna L, Laitman, Robert, Lee, Jimmy, MacCabe, James H, Myles, Nick, Nielsen, Jimmi, Schulte, Peter F, Taylor, David, Verdoux, Helene, Wheeler, Amanda, Freudenreich, Oliver, Siskind, Dan, Honer, William G, Clark, Scott, Correll, Christoph U, Hasan, Alkomiet, Howes, Oliver, Kane, John M, Kelly, Deanna L, Laitman, Robert, Lee, Jimmy, MacCabe, James H, Myles, Nick, Nielsen, Jimmi, Schulte, Peter F, Taylor, David, Verdoux, Helene, Wheeler, Amanda, and Freudenreich, Oliver

Published
2020

44. Psychotic Experiences and Related Distress: A Cross-national Comparison and Network Analysis Based on 7141 Participants From 13 Countries

Author

Wusten, Caroline, Schlier, Bjorn, Jaya, Edo S., Alizadeh, Behrooz Z., Bartels-Velthuis, Agna A., van Beveren, Nico J., Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Delespaul, Philippe, Meijer, Carin J., Myin-Germeys, Inez, Kahn, Rene S., Schirmbeck, Frederike, Simons, Claudia J. P., van Haren, Neeltje E., van Os, Jim, van Winkel, Ruud, Fonseca-Pedrero, Eduardo, Peters, Emmanuelle, Verdoux, Helene, Woodward, Todd S., Ziermans, Tim B., Lincoln, Tania M., Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatry, Brein en Cognitie (Psychologie, FMG), APH - Mental Health, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Perceptual and Cognitive Neuroscience (PCN), Life Course Epidemiology (LCE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)

Subjects
Male, SYMPTOMS, 0302 clinical medicine, Cultural values, Medicine, Young adult, COMMUNITY ASSESSMENT, Psychiatry, Aged, 80 and over, GENERAL-POPULATION, RISK, education.field_of_study, cross-cultural comparison, Middle Aged, DEPRESSION, CAPE, high-risk status, Psychiatry and Mental health, Distress, Schizophrenia, Female, epidemiology, Life Sciences & Biomedicine, Clinical psychology, Adult, endocrine system, DIMENSIONS, Cross national comparison, Adolescent, Population, Positive correlation, 03 medical and health sciences, Young Adult, Humans, education, network approach, Developing Countries, psychosis continuum, METAANALYSIS, Aged, CONFIRMATORY FACTOR-ANALYSIS, Science & Technology, business.industry, Developed Countries, medicine.disease, Cross-cultural studies, 030227 psychiatry, culture, body regions, schizophrenia, MODEL, CONTINUUM, Psychotic Disorders, psychosis phenotype, business, human activities, 030217 neurology & neurosurgery, Stress, Psychological, Regular Articles
Abstract

Psychotic experiences (PEs) are common in the general population but do not necessarily reflect a risk status if they occur in relative isolation or are not distressing. Emerging evidence suggests that PEs might be experienced as more benign for individuals from collectivistic low- and middle-income countries (LAMIC) compared with individualistic high-income countries (HIC). The aim of this study was to determine whether: (1) self-reported PEs are less distressing in community samples from LAMIC than from HIC; (2) the network of PEs is significantly less connected in a sample from LAMIC than from HIC. Adults from 8 HIC (n = 4669) and 5 LAMIC (n = 2472) were compared. The lifetime frequency of PEs and related distress were assessed with the Community Assessment of Psychic Experiences. We analyzed the associations of PEs with distress and country type. The interconnection of PEs was visualized by a network analysis and tested for differences in global connection strengths. The average endorsement rates of PEs were significantly higher in LAMIC than in HIC (χ2 = 1772.87, P < .01, Φcramer = 0.50). There was a universal positive correlation between higher frequency of PEs and more distress, but the distress levels controlled for frequency were significantly higher in HIC (R2 = 0.11; b = 0.26; SE = 0.01; T = 17.68; P < .001). Moreover, the network of PEs was significantly less connected in LAMIC (S = 0.40, P < .05). The findings indicate that PEs are of less clinical relevance in LAMIC compared with HIC. The universal use of current high-risk criteria might thus not be adequate without consideration of associated distress and cultural values.

Published
2018

49. Clozapine and COVID-19: The authors respond

Author

Siskind, Dan, primary, Honer, William G., additional, Clark, Scott, additional, Correll, Christoph U., additional, Hasan, Alkomiet, additional, Howes, Oliver, additional, Kane, John M., additional, Kelly, Deanna L., additional, Laitman, Robert, additional, Lee, Jimmy, additional, MacCabe, James H., additional, Myles, Nick, additional, Nielsen, Jimmi, additional, Schulte, Peter F., additional, Taylor, David, additional, Verdoux, Helene, additional, Wheeler, Amanda, additional, and Freudenreich, Oliver, additional

Published
2020
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50. Consensus statement on the use of clozapine during the COVID-19 pandemic

Author

Siskind, Dan, primary, Honer, William G., additional, Clark, Scott, additional, Correll, Christoph U., additional, Hasan, Alkomiet, additional, Howes, Oliver, additional, Kane, John M., additional, Kelly, Deanna L., additional, Laitman, Robert, additional, Lee, Jimmy, additional, MacCabe, James H., additional, Myles, Nick, additional, Nielsen, Jimmi, additional, Schulte, Peter F., additional, Taylor, David, additional, Verdoux, Helene, additional, Wheeler, Amanda, additional, and Freudenreich, Oliver, additional

Published
2020
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