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Your search keyword '"VEGFR-2, Single-nucleotide polymorphisms"' showing total 1 results
Start Over Descriptor "VEGFR-2, Single-nucleotide polymorphisms"
1 results on '"VEGFR-2, Single-nucleotide polymorphisms"'

1. c-MET/VEGFR-2 co-localisation impacts on survival following bevacizumab therapy in epithelial ovarian cancer: an exploratory biomarker study of the phase 3 ICON7 trial

Author

Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou, and Gordon C. Jayson

Subjects
Epithelial ovarian cancer, Bevacizumab, c-MET, VEGFR-2, Single-nucleotide polymorphisms, Medicine
Abstract

Highlights Tissue microarrays and germline DNA from women recruited to the phase 3 trial, ICON7, underwent quantitative immunofluorescence for c-MET/VEGFR-2 co-expression and genetic sequencing for single nucleotide polymorphisms (SNPs) VEGF-pathway genes. High c-MET/VEGFR-2 co-localisation on tumour tissue independently predicted worse survival in bevacizumab-treated epithelial ovarian cancer. The VEGFR-2 rs2305945 SNPs also independently predict worse survival in bevacizumab-treated epithelial ovarian cancer.

Published
2022
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