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30 results on '"VECHIN, FELIPE C."'

2. Acute and Chronic Changes in Muscle Androgen Receptor Markers Are Not Associated with Muscle Hypertrophy in Women and Men.

Author

BERGAMASCO, JOÃO G. A., SCARPELLI, MAÍRA C., GODWIN, JOSHUA S., MESQUITA, PAULO H. C., CHAVES, TALISSON S., DA SILVA, DEIVID G., BITTENCOURT, DIEGO, DIAS, NATHALIA F., MEDALHA JUNIOR, RICARDO A., CARELLO FILHO, PAULO C., ANGLERI, VITOR, COSTA, LUIZ A. R., MICHEL, J. MAX, VECHIN, FELIPE C., KAVAZIS, ANDREAS N., UGRINOWITSCH, CARLOS, ROBERTS, MICHAEL D., and LIBARDI, CLEITON A.

Published
2024
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3. Androgen receptor markers do not differ between nonresponders and responders to resistance training-induced muscle hypertrophy.

Author

Bergamasco, João G. A., Scarpelli, Maíra C., Godwin, Joshua S., Mesquita, Paulo H. C., Chaves, Talisson S., Silva, Deivid G. da, Bittencourt, Diego, Dias, Nathalia F., A. Medalha Jr., Ricardo, Filho, Paulo C. Carello, Angleri, Vitor, Costa, Luiz A. R., Michel, J. Max, Vechin, Felipe C., Kavazis, Andreas N., Ugrinowitsch, Carlos, Roberts, Michael D., and Libardi, Cleiton A.

Subjects
ANDROGEN receptors, MUSCULAR hypertrophy, RESISTANCE training, WESTERN immunoblotting, CONFIDENCE intervals
Abstract

The aim of this study was to investigate whether baseline values and acute and chronic changes in androgen receptors (AR) markers, including total AR, cytoplasmic (cAR), and nuclear (nAR) fractions, as well as DNA-binding activity (AR-DNA), are involved in muscle hypertrophy responsiveness by comparing young nonresponder and responder individuals. After 10 wk of resistance training (RT), participants were identified as nonresponders using two typical errors (TE) obtained through two muscle cross-sectional area (mCSA) ultrasound measurements (2 × TE; 4.94%), and the highest responders within our sample were numerically matched. Muscle biopsies were performed at baseline, 24 h after the first RT session (acute responses), and 96 h after the last session (chronic responses). AR, cAR, and nAR were analyzed using Western blotting, and AR-DNA was analyzed using an ELISA-oligonucleotide assay. Twelve participants were identified as nonresponders (ΔmCSA: −1.32%) and 12 as responders (ΔmCSA: 21.35%). There were no baseline differences between groups in mCSA, AR, cAR, nAR, or AR-DNA (P > 0.05). For acute responses, there was a significant difference between nonresponders (+19.5%) and responders (−14.4%) in AR-DNA [effect size (ES) = −1.39; 95% confidence interval (CI): −2.53 to −0.16; P = 0.015]. There were no acute between-group differences in any other AR markers (P > 0.05). No significant differences between groups were observed in chronic responses across any AR markers (P > 0.05). Nonresponders and responders presented similar baseline, acute, and chronic results for the majority of the AR markers. Thus, our findings do not support the influence of AR markers on muscle hypertrophy responsiveness to RT in untrained individuals. NEW & NOTEWORTHY: We explored, for the first time, the influence of androgen receptor (AR) through the separation of cytoplasmic and nuclear cell fractions [i.e., cytoplasmic androgen receptor (cAR), nuclear androgen receptor (nAR), and androgen receptor DNA-binding activity (AR-DNA)] on muscle hypertrophy responsiveness to resistance training. The absence of muscle hypertrophy in naïve individuals does not seem to be explained by baseline values, and acute or chronic changes in AR markers. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Higher resistance training volume offsets muscle hypertrophy nonresponsiveness in older individuals

Author

Lixandrão, Manoel E., primary, Bamman, Marcas, additional, Vechin, Felipe C., additional, Conceicao, Miguel S., additional, Telles, Guilherme, additional, Longobardi, Igor, additional, Damas, Felipe, additional, Lavin, Kaleen M., additional, Drummer, Devin J., additional, McAdam, Jeremy S., additional, Dungan, Cory M., additional, Leitão, Alice E., additional, Riani Costa, Luiz A., additional, Aihara, André Y., additional, Libardi, Cleiton A., additional, Gualano, Bruno, additional, and Roschel, Hamilton, additional

Published
2024
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8. Acute changes in serum and skeletal muscle steroids in resistance-trained men

Author

Vechin, Felipe C., primary, Vingren, Jakob L., additional, Telles, Guilherme D., additional, Conceicao, Miguel S., additional, Libardi, Cleiton A., additional, Lixandrao, Manoel E., additional, Damas, Felipe, additional, Cunha, Telma F., additional, Brum, Patricia C., additional, Riani, Luiz A., additional, and Ugrinowitsch, Carlos, additional

Published
2023
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15. Time Course of Proteolysis Biomarker Responses to Resistance, High-Intensity Interval, and Concurrent Exercise Bouts

Author

Godwin, Joshua S., Telles, Guilherme D., Vechin, Felipe C., Conceição, Miguel S., Ugrinowitsch, Carlos, Roberts, Michael D., and Libardi, Cleiton A.

Abstract

Godwin, JS, Telles, GD, Vechin, FC, Conceição, MS, Ugrinowitsch, C, Roberts, MD, and Libardi, CA. Time course of proteolysis biomarker responses to resistance, high-intensity interval, and concurrent exercise bouts. J Strength Cond Res37(12): 2326–2332, 2023—Concurrent exercise (CE) combines resistance exercise (RE) and high-intensity interval exercise (HIIE) in the same training routine, eliciting hypertrophy, strength, and cardiovascular benefits over time. Some studies suggest that CE training may hamper muscle hypertrophy and strength adaptations compared with RE training alone. However, the underlying mechanisms related to protein breakdown are not well understood. The purpose of this study was to examine how a bout of RE, HIIE, or CE affected ubiquitin-proteasome and calpain activity and the expression of a few associated genes, markers of skeletal muscle proteolysis. Nine untrained male subjects completed 1 bout of RE (4 sets of 8–12 reps), HIIE (12 × 1 minute sprints at V̇o2peak minimum velocity), and CE (RE followed by HIIE), in a crossover design, separated by 1-week washout periods. Muscle biopsies were obtained from the vastus lateralis before (Pre), immediately post, 4 hours (4 hours), and 8 hours (8 hours) after exercise. FBXO32 mRNA expression increased immediately after exercise (main time effect; p< 0.05), and RE and CE presented significant overall values compared with HIIE (p< 0.05). There was a marginal time effect for calpain-2 mRNA expression (p< 0.05), with no differences between time points (p> 0.05). No significant changes occurred in TRIM63/MuRF-1 and FOXO3 mRNA expression, or 20S proteasome or calpain activities (p> 0.05). In conclusion, our findings suggest that 1 bout of CE does not promote greater changes in markers of skeletal muscle proteolysis compared with 1 bout of RE or HIIE.

Published
2023
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20. Aerobic Exercise-Induced Changes in Cardiorespiratory Fitness in Breast Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis

Author

Maginador, Guilherme, primary, Lixandrão, Manoel E., additional, Bortolozo, Henrique I., additional, Vechin, Felipe C., additional, Sarian, Luís O., additional, Derchain, Sophie, additional, Telles, Guilherme D., additional, Zopf, Eva, additional, Ugrinowitsch, Carlos, additional, and Conceição, Miguel S., additional

Published
2020
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21. Low-intensity resistance training with partial blood flow restriction and high-intensity resistance training induce similar changes in skeletal muscle transcriptome in elderly humans

Author

Vechin, Felipe C., primary, Libardi, Cleiton A., additional, Conceição, Miguel S., additional, Damas, Felipe, additional, Cavaglieri, Claudia R., additional, Chacon-Mikahil, Mara Patricia T., additional, Coutinho, Luiz L., additional, Andrade, Sonia C.S., additional, Neves Jr, Manoel T., additional, Roschel, Hamilton, additional, Tricoli, Valmor, additional, Baptista, Igor L., additional, Moriscot, Anselmo A., additional, and Ugrinowitsch, Carlos, additional

Published
2019
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22. Early- and later-phases satellite cell responses and myonuclear content with resistance training in young men

Author

Damas, Felipe, primary, Libardi, Cleiton A., additional, Ugrinowitsch, Carlos, additional, Vechin, Felipe C., additional, Lixandrão, Manoel E., additional, Snijders, Tim, additional, Nederveen, Joshua P., additional, Bacurau, Aline V., additional, Brum, Patricia, additional, Tricoli, Valmor, additional, Roschel, Hamilton, additional, Parise, Gianni, additional, and Phillips, Stuart M., additional

Published
2018
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23. Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage

Author

Damas, Felipe, primary, Phillips, Stuart M., additional, Libardi, Cleiton A., additional, Vechin, Felipe C., additional, Lixandrão, Manoel E., additional, Jannig, Paulo R., additional, Costa, Luiz A. R., additional, Bacurau, Aline V., additional, Snijders, Tim, additional, Parise, Gianni, additional, Tricoli, Valmor, additional, Roschel, Hamilton, additional, and Ugrinowitsch, Carlos, additional

Published
2016
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27. Comparisons Between Low-Intensity Resistance Training With Blood Flow Restriction and High-Intensity Resistance Training on Quadriceps Muscle Mass and Strength in Elderly

Author

Vechin, Felipe C., primary, Libardi, Cleiton A., additional, Conceição, Miguel S., additional, Damas, Felipe R., additional, Lixandrão, Manoel E., additional, Berton, Ricardo P.B., additional, Tricoli, Valmor A.A., additional, Roschel, Hamilton A., additional, Cavaglieri, Claudia R., additional, Chacon-Mikahil, Mara Patricia T., additional, and Ugrinowitsch, Carlos, additional

Published
2015
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28. Resistance Training in the Elderly

Author

Vechin, Felipe C., primary, Libardi, Cleiton, additional, Conceição, Miguel, additional, Nogueira, Felipe R.D., additional, Berton, Ricardo, additional, Lixandrão, Manoel, additional, Frota, Thiago, additional, Chacon-Mikahil, Mara Patricia, additional, Cavaglieri, Claudia, additional, and Ugrinowitsch, Carlos, additional

Published
2014
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29. Time-Course of Skeletal Muscle Hypertrophy with Resistance Training in Older Adults

Author

Nogueira, Felipe R. D., primary, Lixandrão, Manoel E., additional, Libardi, Cleiton A., additional, Conceição, Miguel S., additional, Berton, Ricardo P. B., additional, Vechin, Felipe C., additional, Frota, Thiago, additional, Chacon-Mikahil, Mara Patricia T., additional, Cavaglieri, Claudia R., additional, Bottaro, Martin, additional, and Ugrinowitsch, Carlos, additional

Published
2014
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30. Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis.

Author

Lixandrão ME, Ugrinowitsch C, Berton R, Vechin FC, Conceição MS, Damas F, Libardi CA, and Roschel H

Subjects
Humans, Weight-Bearing, Adaptation, Physiological, Muscle Strength physiology, Muscle, Skeletal blood supply, Muscle, Skeletal physiology, Regional Blood Flow physiology, Resistance Training methods
Abstract

Background: Low-load resistance training (< 50% of one-repetition maximum [1RM]) associated with blood-flow restriction (BFR-RT) has been thought to promote increases in muscle strength and mass. However, it remains unclear if the magnitude of these adaptations is similar to conventional high-load resistance training (> 65% 1RM; HL-RT)., Objective: To compare the effects of HL- versus BFR-RT on muscle adaptations using a systematic review and meta-analysis procedure., Methods: Studies were identified via electronic databases based on the following inclusion criteria: (a) pre- and post-training assessment of muscular strength; (b) pre- and post-training assessment of muscle hypertrophy; (c) comparison of HL-RT vs. BFR-RT; (d) score ≥ 4 on PEDro scale; (e) means and standard deviations (or standard errors) are reported from absolute values or allow estimation from graphs. If this last criterion was not met, data were directly requested from the authors., Results: The main results showed higher increases in muscle strength for HL- as compared with BFR-RT, even when considering test specificity, absolute occlusion pressure, cuff width, and occlusion pressure prescription. Regarding the hypertrophic response, results revealed similar effects between HL- and BFR-RT, regardless of the absolute occlusion pressure, cuff width, and occlusion pressure prescription., Conclusions: Based on the present data, maximum muscle strength may be optimized by specific training methods (i.e., HL-RT) while both HL- and BFR-RT seem equally effective in increasing muscle mass. Importantly, BFR-RT is a valid and effective approach for increasing muscle strength in a wide spectrum of ages and physical capacity, although it may seem particularly of interest for those individuals with physical limitations to engage in HL-RT.

Published
2018
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