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Case presentation: A middle-aged woman presented to the emergency department with a chiefcomplaint of abdominal pain, fever, vomiting, and diarrhea. Abdominal computed tomographyrevealed gastric pneumatosis and air in the portal system. The patient had an unfavorable clinicalcourse with pneumoperitoneum and septic shock due to secondary peritonitis. She underwentemergency laparotomy where neoformation of the mesentery root was found with infiltration of thesmall intestine and jejunal perforation. The anatomopathological study of the tumor revealed that itwas a desmoid tumor.Discussion: To our knowledge this is the first report in the literature of gastric pneumatosis as theinitial presentation of a mesenteric desmoid tumor. Although it usually has a benign clinical course,its locally invasive characteristics can lead to critical illness. Physicians shouldn’t overlook thesetypes of complications, as early identification and surgical intervention can modify the prognosis andshorten hospital stay.

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Short fieldtrips offer unique opportunities to teach cultural relativism in context. Through travel, theatrical practices can be experienced as nodes in complex social webs, where the material aspects of performance are inseparable from the people who make, sponsor and attend performances. The author reflects on his experiences organising theatre fieldtrips to Indonesia over a six-year period (2013-2018) to think about the implications of travel more generally for the pedagogy of theatre, using concepts from geography, anthropology and theatre studies. Thinking of field trips as dramaturgical processes provides a framework to better devise, conduct and evaluate such trips.

Antisense oligonucleotides (ASOs) targeting pathologic RNAs have shown promising therapeutic corrections for many genetic diseases including myotonic dystrophy (DM1). Thus, ASO strategies for DM1 can abolish the toxic RNA gain-of-function mechanism caused by nucleus-retained mutant DMPK (DM1 protein kinase) transcripts containing CUG expansions (CUGexps). However, systemic use of ASOs for this muscular disease remains challenging due to poor drug distribution to skeletal muscle. To overcome this limitation, we test an arginine-rich Pip6a cell-penetrating peptide and show that Pip6aconjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced ASO delivery into striated muscles of DM1 mice following systemic administration in comparison with unconjugated PMO and other ASO strategies. Thus, low-dose treatment with Pip6a-PMO-CAG targeting pathologic expansions is sufficient to reverse both splicing defects and myotonia in DM1 mice and normalizes the overall disease transcriptome. Moreover, treated DM1 patient-derived muscle cells showed that Pip6a-PMO-CAG specifically targets mutant CUGexp-DMPK transcripts to abrogate the detrimental sequestration of MBNL1 splicing factor by nuclear RNA foci and consequently MBNL1 functional loss, responsible for splicing defects and muscle dysfunction. Our results demonstrate that Pip6a-PMO-CAG induces long- lasting correction with high efficacy of DM1-associated phenotypes at both molecular and functional levels, and strongly support the use of advanced peptide conjugates for systemic corrective therapy in DM1., Introduction Myotonic dystrophy (DM1), one of the most common muscular dystrophies in adults (1), is an RNA-dominant disorder caused by the expression of expanded microsatellite repeats located in the 3' [...]

The article presents a theoretical generalisation and solution of a current scientific and applied problem which develops theoretical principles, methodological approaches and scientific and practical recommendations for improving the mechanism of labour efficiency management in terms of innovation-oriented development of enterprises. It is substantiated that in the conditions of innovation-oriented development of ecosystems, including enterprises, the disclosure of the essence of labour efficiency requires introduction of a dual quantitative–qualitative approach: on the one hand, labour efficiency reflects the ratio of the manufactured products (tangible and intangible benefits) and corresponding living labour costs (quantitative aspect) and, on the other hand, it is the result of using productive abilities of people, characterised by manufactured products of a particular consumer quality with the creation of added value (qualitative aspect). Conceptual bases of improvement of the mechanism of labour efficiency management at enterprises were developed. They are based on certain tasks, functions, principles, methods of labour efficiency management and the formed system of factors of influence and the revealed factors and reserves of an increase in labour efficiency. They presuppose development and realisation of the corresponding programme, which aims to: optimise total labour costs; improve quality of products at a constant mass and satisfaction with the work process of all its participants; ensure positive changes in material well-being and quality of life on the basis of the formation of modern innovation infrastructure of the enterprise. [ABSTRACT FROM AUTHOR]

This article delves into the escalating frequency of financial crises and their repercussions on national economies, emphasizing the imperative need for both the global community and individual nations to establish mechanisms that can effectively counter financial shocks. The primary line of defence within banking institutions is their own capital. Consequently, the adequacy of a country's own capital plays a pivotal role in determining the robustness of its banking system. The article presents an in-depth analysis of the dynamics of fundamental capital types, including own and borrowed capital, and other economic indicators, with a specific focus on the proportion of own capital within these factors in Portugal, an integral part of the European community. The study employs correlation-regression analysis to explore the interdependencies among capital, liabilities, assets, income, and Gross Domestic Product (GDP). Regression models are developed to investigate the influence on a bank's own capital. The analysis substantiates the hypothesis regarding the interconnections among these key indicators. Based on the findings, recommendations are made for the implementation of a mechanism to ascertain capital sufficiency. The article places significant emphasis on identifying and utilizing instruments that facilitate the achievement of this objective, ultimately contributing to bolstering financial resilience in Portugal and beyond. [ABSTRACT FROM AUTHOR]