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131 results on '"VAN RIJEN, HAROLD V.M."'

1. To Test or Not to Test? The Graduate Record Examinations: Predictive Validity toward Graduate Study Success on Research Masters’ Programs in a Large European University

Author

BMS Algemeen, BMW Algemeen, Kurysheva, Anastasia, Dilaver, Gönül, Fox, Christine Merie, Kell, Harrison, Kern, Matthias Robert, van Rijen, Harold V.M., BMS Algemeen, BMW Algemeen, Kurysheva, Anastasia, Dilaver, Gönül, Fox, Christine Merie, Kell, Harrison, Kern, Matthias Robert, and van Rijen, Harold V.M.

Published
2024

2. Entry-level career paths in the life sciences: generic skills in Dutch job postings

Author

BMS Algemeen, Medische Fysiologie, Circulatory Health, Expertisecentrum Alg., van Ravenswaaij, Heleen, ter Meulen-de Jong, Sanne, de Kleijn, Renske A.M., Dilaver, Gonul, van der Schaaf, Marieke F., van Rijen, Harold V.M., BMS Algemeen, Medische Fysiologie, Circulatory Health, Expertisecentrum Alg., van Ravenswaaij, Heleen, ter Meulen-de Jong, Sanne, de Kleijn, Renske A.M., Dilaver, Gonul, van der Schaaf, Marieke F., and van Rijen, Harold V.M.

Published
2024

6. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy

Author

Noorman, Maartje, Hakim, Sara, Kessler, Elise, Groeneweg, Judith A, Cox, Moniek G.P.J., Asimaki, Angeliki, van Rijen, Harold V.M., van Stuijvenberg, Leonie, Chkourko, Halina, van der Heyden, Marcel A.G., Vos, Marc A., de Jonge, Nicolaas, van der Smagt, Jasper J., Dooijes, Dennis, Vink, Aryan, de Weger, Roel A., Varro, Andras, de Bakker, Jacques M.T., Saffitz, Jeffrey E., Hund, Thomas J., Mohler, Peter J., Delmar, Mario, Hauer, Richard N.W., and van Veen, Toon A.B.

Published
2013
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8. The generic skills learning systematic: Evaluating university students’ learning after complex problem-solving

Author

BMS Algemeen, Expertisecentrum Alg., van Ravenswaaij, Heleen, Bouwmeester, Rianne A.M., van der Schaaf, Marieke F., Dilaver, Gönül, van Rijen, Harold V.M., de Kleijn, Renske A.M., BMS Algemeen, Expertisecentrum Alg., van Ravenswaaij, Heleen, Bouwmeester, Rianne A.M., van der Schaaf, Marieke F., Dilaver, Gönül, van Rijen, Harold V.M., and de Kleijn, Renske A.M.

Published
2022

15. Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model

Author

Stein, Mera, Boulaksil, Mohamed, Jansen, John A., Herold, Eva, Noorman, Maartje, Joles, Jaap A., van Veen, Toon A.B., Houtman, Marien J.C., Engelen, Markus A., Hauer, Richard N.W., de Bakker, Jacques M.T., and van Rijen, Harold V.M.

Subjects
Arrhythmia -- Risk factors, Arrhythmia -- Genetic aspects, Arrhythmia -- Prevention, Fibrosis -- Complications and side effects, Fibrosis -- Drug therapy, Fibrosis -- Research, Renin-angiotensin system -- Physiological aspects, Renin-angiotensin system -- Genetic aspects, Renin-angiotensin system -- Research, Biological sciences
Abstract

Myocardial fibrosis increases arrhythmia vulnerability of the diseased heart. The renin-angiotensin-aldosterone system (RAAS) governs myocardial collagen synthesis. We hypothesized that reducing cardiac fibrosis by chronic RAAS inhibition would result in reduced arrhythmia vulnerability of the senescent mouse heart. Wild-type mice (52 wk old) were treated for 36 wk: 1) untreated control (C); 2) eplerenone (E); 3) losartan (L); and 4) cotreatment with eplerenone and losartan (EL). Ventricular epicardial activation mapping was performed on Langendorff-perfused hearts. Arrhythmia inducibility was tested by one to three premature stimuli and burst pacing. Longitudinal and transverse conduction velocity and dispersion of conduction were determined during pacing at a basic cycle length of 150 ms. Sirius red staining (collagen) was performed. As a result, in the RV of mice in the E, L, and EL groups, transverse conduction velocity was significantly increased and anisotropic ratio was significantly decreased compared with those values of mice in the C group. Anisotropic reentrant arrhythmias were induced in 52% of untreated mice and significantly reduced to 22%, 26%, and 16% in the E, L, and EL groups, respectively. Interstitial fibrosis was significantly decreased in both the RV and LV of all treated groups. Scattered patches of replacement fibrosis were found in 90% of untreated hearts, which were significantly reduced in the E, L, and EL groups. A strong correlation between the abundance of patchy fibrosis and arrhythmia inducibility was found. In conclusion, chronic RAAS inhibition limited aging-related interstitial fibrosis. The lower arrhythmogeneity of treated mice was directly correlated to the reduced amount of patchy fibrosis. renin-angiotensin-aldosterone system inhibition doi: 10.1152/ajpheart.01137.2009.

Published
2010

21. Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias

Author

Boulaksil, Mohamed, Winckels, Stephan K.G., Engelen, Markus A., Stein, Mèra, van Veen, Toon A.B., Jansen, John A., Linnenbank, André C., Bierhuizen, Marti F.A., Groenewegen, W. Antoinette, van Oosterhout, Matthijs F.M., Kirkels, Johannes H., de Jonge, Nicolaas, Varró, András, Vos, Marc A., de Bakker, Jacques M.T., and van Rijen, Harold V.M.

Published
2010
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25. Audio peer feedback to promote deep learning in online education

Author

Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., Grobbee, Diederick E., Leerstoel van Tartwijk, Education and Learning: Development in Interaction, Leerstoel van Tartwijk, and Education and Learning: Development in Interaction

Subjects
media_common.quotation_subject, Audio equipment, online learning, Context (language use), Education, 0502 economics and business, audio, learning strategies, media_common, peer feedback, Medical education, Peer feedback, business.industry, Deep learning, 05 social sciences, Educational technology, 050301 education, Workload, teaching, Computer Science Applications, teaching/learning strategies, Transformative learning, Feeling, deep approaches to learning, 050211 marketing, Artificial intelligence, business, Psychology, 0503 education
Abstract

We investigated the relation between providing and receiving audio peer feedback with a deep approach to learning within online education. Online students were asked to complete peer feedback assignments. Data through a questionnaire with 108 respondents and 14 interviews were used to measure to what extent deep learning was perceived and why. Results support the view that both providing and receiving audio peer feedback indeed promote deep learning. As a consequence of the peer feedback method, the following student mechanisms were triggered: “feeling personally committed,” “probing back and forth,” and “understanding one's own learning process.” Particularly important for both providing and receiving feedback is feeling personally committed. Results also show that mechanisms were a stronger predictor for deep learning when providing than when receiving. Given the context in which instructors face an increasing number of students and a high workload, students may be supported by online audio peer feedback as a method to choose a deep approach to learning.

Published
2019

29. Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress

Author

van Opbergen, Chantal J.M., primary, Noorman, Maartje, additional, Pfenniger, Anna, additional, Copier, Jaël S., additional, Vermij, Sarah H., additional, Li, Zhen, additional, van der Nagel, Roel, additional, Zhang, Mingliang, additional, de Bakker, Jacques M.T., additional, Glass, Aaron M., additional, Mohler, Peter J., additional, Taffet, Steven M., additional, Vos, Marc A., additional, van Rijen, Harold V.M., additional, Delmar, Mario, additional, and van Veen, Toon A.B., additional

Published
2019
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31. Audio peer feedback to promote deep learning in online education

Author

Leerstoel van Tartwijk, Education and Learning: Development in Interaction, Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., Grobbee, Diederick E., Leerstoel van Tartwijk, Education and Learning: Development in Interaction, Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., and Grobbee, Diederick E.

Published
2019

33. Strengthening dialogic peer feedback aiming for deep learning in SPOCs

Author

Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., Grobbee, Diederick E., Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., and Grobbee, Diederick E.

Abstract

This study is focused on how peer feedback in SPOCs (Small Private Online Courses) can effectively lead to deep learning. Promoting deep learning in online courses, such as SPOCs, is often a challenge. We aimed for deep learning by reinforcement of ‘feedback dialogue’ as scalable intervention. Students provided peer feedback as a dialogue, both individually and as a group. They were instructed to rate each other's feedback, which was aimed at deep learning. Data from questionnaires from 41 students of a master epidemiology course were used to measure for each feedback assignment to what extent deep learning was perceived. The feedback received by students who scored extremely high or low on the questionnaire was analyzed in order to find out which features of the feedback led to deep learning. In addition, students were interviewed to retrieve information about the underlying mechanisms. The results support the view that peer feedback instruction and peer feedback rating lead to peer feedback dialogues that, in turn, promote deep learning in SPOCs. The value of peer feedback appears to predominantly result from the dialogue it triggers, rather than the feedback itself. Especially helpful for students is the constant attention to how one provides peer feedback: by instruction, by having to rate feedback and therefore by repeatedly having to reflect. The dialogue is strengthened because students question feedback from peers in contrast to feedback from their instructor. As a result, they continue to think longer and deeper, which enables deep learning.

Published
2018

34. Strengthening dialogic peer feedback aiming for deep learning in SPOCs

Author

Afd Onderwijsontwikkeling, Leerstoel van Tartwijk, Education and Learning: Development in Interaction, Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., Grobbee, Diederick E., Afd Onderwijsontwikkeling, Leerstoel van Tartwijk, Education and Learning: Development in Interaction, Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., and Grobbee, Diederick E.

Published
2018

35. Strengthening dialogic peer feedback aiming for deep learning in SPOCs

Author

Epidemiology & Health Economics, Master Epidemiologie, Julius Academy Bureau, BMS Algemeen, Circulatory Health, Cardiovasculaire Epi Team 9, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., Grobbee, Diederick E., Epidemiology & Health Economics, Master Epidemiologie, Julius Academy Bureau, BMS Algemeen, Circulatory Health, Cardiovasculaire Epi Team 9, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Filius, Renée M., de Kleijn, Renske A.M., Uijl, Sabine G., Prins, Frans J., van Rijen, Harold V.M., and Grobbee, Diederick E.

Published
2018

38. Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent

Author

Takanari, Hiroki, primary, Bourgonje, Vincent J.A., additional, Fontes, Magda S.C., additional, Raaijmakers, Antonia J.A., additional, Driessen, Helen, additional, Jansen, John A., additional, van der Nagel, Roel, additional, Kok, Bart, additional, van Stuijvenberg, Leonie, additional, Boulaksil, Mohamed, additional, Takemoto, Yoshio, additional, Yamazaki, Masatoshi, additional, Tsuji, Yukiomi, additional, Honjo, Haruo, additional, Kamiya, Kaichiro, additional, Kodama, Itsuo, additional, Anderson, Mark E., additional, van der Heyden, Marcel A.G., additional, van Rijen, Harold V.M., additional, van Veen, Toon A.B., additional, and Vos, Marc A., additional

Published
2016
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40. Online formative tests linked to microlectures improving academic achievement

Author

Bouwmeester, Rianne A.M., primary, de Kleijn, Renske A.M., additional, Freriksen, Astrid W.M., additional, van Emst, Maarten G., additional, Veeneklaas, Rob J., additional, van Hoeij, Maggy J.W., additional, Spinder, Matty, additional, Ritzen, Magda J., additional, ten Cate, Olle Th.J., additional, and van Rijen, Harold V.M., additional

Published
2013
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41. Reduced Cx43 Expression Triggers Increased Fibrosis Due to Enhanced Fibroblast Activity

Author

Jansen, John A., primary, van Veen, Toon A.B., additional, de Jong, Sanne, additional, van der Nagel, Roel, additional, van Stuijvenberg, Leonie, additional, Driessen, Helen, additional, Labzowski, Ronald, additional, Oefner, Carolin M., additional, Bosch, Astrid A., additional, Nguyen, Tri Q., additional, Goldschmeding, Roel, additional, Vos, Marc A., additional, de Bakker, Jacques M.T., additional, and van Rijen, Harold V.M., additional

Published
2012
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42. Drug-Induced Torsade de Pointes Arrhythmias in the Chronic AV Block Dog Are Perpetuated by Focal Activity

Author

Boulaksil, Mohamed, primary, Jungschleger, Jerome G., additional, Antoons, Gudrun, additional, Houtman, Marien J.C., additional, de Boer, Teun P., additional, Wilders, Ronald, additional, Beekman, Jet D., additional, Maessen, Jos G., additional, van der Hulst, Ferenc F., additional, van der Heyden, Marcel A.G., additional, van Veen, Toon A.B., additional, van Rijen, Harold V.M., additional, de Bakker, Jacques M.T., additional, and Vos, Marc A., additional

Published
2011
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47. Impaired Impulse Propagation in Scn5a -Knockout Mice

Author

van Veen, Toon A.B., primary, Stein, Mera, additional, Royer, Anne, additional, Le Quang, Khaï, additional, Charpentier, Flavien, additional, Colledge, William H., additional, Huang, Christopher L.-H., additional, Wilders, Ronald, additional, Grace, Andrew A., additional, Escande, Denis, additional, de Bakker, Jacques M.T., additional, and van Rijen, Harold V.M., additional

Published
2005
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49. Mouse Model of SCN5A -Linked Hereditary Lenègre’s Disease

Author

Royer, Anne, primary, van Veen, Toon A.B., additional, Le Bouter, Sabrina, additional, Marionneau, Céline, additional, Griol-Charhbili, Violaine, additional, Léoni, Anne-Laure, additional, Steenman, Marja, additional, van Rijen, Harold V.M., additional, Demolombe, Sophie, additional, Goddard, Catharine A., additional, Richer, Christine, additional, Escoubet, Brigitte, additional, Jarry-Guichard, Thérèse, additional, Colledge, William H., additional, Gros, Daniel, additional, de Bakker, Jacques M.T., additional, Grace, Andrew A., additional, Escande, Denis, additional, and Charpentier, Flavien, additional

Published
2005
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