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1. SNUPN deficiency causes a recessive muscular dystrophy due to RNA mis-splicing and ECM dysregulation

Author

Nashabat, Marwan, Nabavizadeh, Nasrinsadat, Saraçoğlu, Hilal Pırıl, Sarıbaş, Burak, Avcı, Şahin, Börklü, Esra, Beillard, Emmanuel, Yılmaz, Elanur, Uygur, Seyide Ecesu, Kayhan, Cavit Kerem, Bosco, Luca, Eren, Zeynep Bengi, Steindl, Katharina, Richter, Manuela Friederike, Bademci, Guney, Rauch, Anita, Fattahi, Zohreh, Valentino, Maria Lucia, Connolly, Anne M., Bahr, Angela, Viola, Laura, Bergmann, Anke Katharina, Rocha, Maria Eugenia, Peart, LeShon, Castro-Rojas, Derly Liseth, Bültmann, Eva, Khan, Suliman, Giarrana, Miriam Liliana, Teleanu, Raluca Ioana, Gonzalez, Joanna Michelle, Pini, Antonella, Schädlich, Ines Sophie, Vill, Katharina, Brugger, Melanie, Zuchner, Stephan, Pinto, Andreia, Donkervoort, Sandra, Bivona, Stephanie Ann, Riza, Anca, Streata, Ioana, Gläser, Dieter, Baquero-Montoya, Carolina, Garcia-Restrepo, Natalia, Kotzaeridou, Urania, Brunet, Theresa, Epure, Diana Anamaria, Bertoli-Avella, Aida, Kariminejad, Ariana, Tekin, Mustafa, von Hardenberg, Sandra, Bönnemann, Carsten G., Stettner, Georg M., Zanni, Ginevra, Kayserili, Hülya, Oflazer, Zehra Piraye, and Escande-Beillard, Nathalie

Published
2024
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2. Atkin-Lehner theory for Drinfeld modular forms and applications

Author

Valentino, Maria

Subjects
Mathematics - Number Theory, 11F52, 11F25
Abstract

The present paper deals with Atkin-Lehner theory for Drinfeld modular forms. We provide an equivalent definition of $\mathfrak{p}$-newforms (which makes computations easier) and commutativity results between Hecke operators and Atkin-Lehner involutions. As applications we show a criterion for a direct sum decomposition of cusp forms, we exibit $\mathfrak{p}$-newforms arising from lower levels and we provide $\mathfrak{p}$-adic Drinfeld modular forms of level greater than 1.

Published
2020

4. On Drinfeld cusp forms of prime level

Author

Bandini, Andrea and Valentino, Maria

Subjects
Mathematics - Number Theory
Abstract

Let $(P_d)$ be any prime of $\mathbb{F}_q[t]$ of degree $d$ and consider the space of Drinfeld cusp forms of level $P_d$, i.e. for the modular group $\Gamma_0(P_d)$. We provide a definition for oldforms and newforms of level $P_d$. Moreover, when the dimension of the vector space of oldforms is one and $P_1=t$ we prove that the space of cuspforms of level $t$ is the direct sum of oldforms and newforms and that the Hecke operator $\mathbf{T}_t$ acting on Drinfeld cusp forms of level 1 is injective, thus providing more evidence for the conjectures presented and stated in [2] and [3].

Published
2019

5. On the structure and slopes of Drinfeld cusp forms

Author

Bandini, Andrea and Valentino, Maria

Subjects
Mathematics - Number Theory, 11F52 (Primary), 15B99 (Secondary)
Abstract

We define oldforms and newforms for Drinfeld cusp forms of level $t$ and conjecture that their direct sum is the whole space of cusp forms. Moreover we describe explicitly the matrix $U$ associated to the action of the Atkin operator $\mathbf{U}_t$ on cusp forms of level $t$ and use it to compute tables of slopes of eigenforms. Building on such data, we formulate conjectures on bounds for slopes, on the diagonalizability of $\mathbf{U}_t$ and on various other issues. Via the explicit form of the matrix $U$ we are then able to verify our conjectures in various cases (mainly in small weights)., Comment: Final version, to appear in Exp. Math

Published
2018
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10. On the Atkin $U_t$-operator for $\Gamma_0(t)$-invariant Drinfeld cusp forms

Author

Bandini, Andrea and Valentino, Maria

Subjects
Mathematics - Number Theory
Abstract

We study the diagonalizability of the Atkin $U_t$-operator acting on Drinfeld cusp forms for $\Gamma_0(t)$: starting with the slopes of eigenvalues and then moving to the space of cusp forms for $\Gamma_1(t)$ to use Teitelbaum's interpretation as harmonic cocycles which makes computations more explicit. We prove $U_t$ is diagonalizable in odd characteristic for (relatively) small weights and explicitly compute the eigenvalues. In even characteristic we show that it is not diagonalizable when the weight is odd (except for the trivial cases) and prove some cases of non diagonalizability in even weight as well. We also formulate a few conjectures, supported by numerical search, about diagonalizability of $U_t$ and the slopes of its eigenforms., Comment: It contains parts of the previous arXiv:1702.08801 [math:NT], which has now been split in two papers with some new results

Published
2017

11. Euler characteristic and Akashi series for Selmer groups over global function fields

Author

Bandini, Andrea and Valentino, Maria

Subjects
Mathematics - Number Theory
Abstract

Let $A$ be an abelian variety defined over a global function field $F$ of positive characteristic $p$ and let $K/F$ be a $p$-adic Lie extension with Galois group $G$. We provide a formula for the Euler characteristic $\chi(G,Sel_A(K)_p)$ of the $p$-part of the Selmer group of $A$ over $K$. In the special case $G=\mathbb{Z}_p^d$ and $A$ a constant ordinary variety, using Akashi series, we show how the Euler characteristic of the dual of $Sel_A(K)_p$ is related to special values of a $p$-adic $\mathcal{L}$-function.

Published
2017

12. On the diagonalizability of the Atkin U-operator for Drinfeld cusp forms

Author

Bandini, Andrea and Valentino, Maria

Subjects
Mathematics - Number Theory, Primary 11F52, 11F25, Secondary 11B65, 20E08, 11C20
Abstract

We study the diagonalizability of the Atkin $U$-operator acting on Drinfeld cusp forms for $\Gamma_1(t)$ and $\Gamma(t)$ using Teitelbaum's interpretation as harmonic cocycles. We prove $U$ is diagonalizable for small weights and explicitly compute the eigenvalues. We also formulate a conjecture, supported by numerical search and proofs in some special cases, about non diagonalizability of $U$ in even characteristic., Comment: This paper has been withdrawn and substituted with the two new ones arXiv:1710.01036 and arXiv:1710.01038 containing new developments

Published
2017

17. Repression of autocrine pheromone signaling leads to fusaric acid over-production.

Author

Staropoli, Alessia, Guastaferro, Valentino Maria, Vinale, Francesco, Turrà, David, Di Costanzo, Luigi, and Vitale, Stefania

Subjects
PHEROMONES, OVERPRODUCTION, PICOLINIC acid, PHYTOPATHOGENIC microorganisms, FUSARIUM oxysporum, ACID derivatives
Abstract

Fusaric acid (FA), a picolinic acid derivative, is a natural substance produced by a wide variety of fungal plant pathogens belonging to the Fusarium genus. As a metabolite, fusaric acid exerts several biological activities including metal chelation, electrolyte leakage, repression of ATP synthesis, and direct toxicity on plants, animals and bacteria. Prior studies on the structure of fusaric acid revealed a co-crystal dimeric adduct between FA and 9,10-dehydrofusaric acid. During an ongoing search for signaling genes differentially regulating FA production in the fungal pathogen Fusarium oxysporum (Fo), we found that mutants lacking pheromone expression have an increased production of FA compared to the wild type strain. Noteworthy, crystallographic analysis of FA extracted from Fo culture supernatants showed that crystals are formed by a dimeric form of two FA molecules (1:1 molar stoichiometry). Overall, our results suggest that pheromone signaling in Fo is required to regulate the synthesis of fusaric acid. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Headache in beta-thalassemia: An Italian multicenter clinical, conventional MRI and MR-angiography case-control study

Author

Tartaglione, Immacolata, Caiazza, Martina, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Maietta, Caterina, Valentino, Maria Sole, Russo, Camilla, Roberti, Domenico, Casale, Maddalena, Elefante, Andrea, Femina, Gianluca, Esposito, Fabrizio, Ponticorvo, Sara, Russo, Andrea G., Canna, Antonietta, Ermani, Mario, Cirillo, Mario, Perrotta, Silverio, and Manara, Renzo

Published
2020
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21. Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia

Author

Manara, Renzo, Ponticorvo, Sara, Perrotta, Silverio, Barillari, Maria Rosaria, Costa, Giuseppe, Brotto, Davide, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Carafa, Pasquale Alessandro, Canna, Antonietta, Russo, Andrea Gerardo, Troisi, Donato, Caiazza, Martina, Ammendola, Federica, Roberti, Domenico, Santoro, Claudia, Picariello, Stefania, Valentino, Maria Sole, Inserra, Emanuela, Carfora, Roberta, Cirillo, Mario, Raimo, Simona, Santangelo, Gabriella, di Salle, Francesco, Esposito, Fabrizio, and Tartaglione, Immacolata

Published
2021
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22. On Selmer groups of abelian varieties over $\ell$-adic Lie extensions of global function fields

Author

Bandini, Andrea and Valentino, Maria

Subjects
Mathematics - Number Theory, 11R23, 11G35
Abstract

Let $F$ be a global function field of characteristic $p>0$ and $A/F$ an abelian variety. Let $K/F$ be an $\l$-adic Lie extension ($\l\neq p$) unramified outside a finite set of primes $S$ and such that $\Gal(K/F)$ has no elements of order $\l$. We shall prove that, under certain conditions, $Sel_A(K)_\l^\vee$ has no nontrivial pseudo-null submodule., Comment: 14 pages

Published
2013

23. Control Theorems for l-adic Lie extensions of global function fields

Author

Bandini, Andrea and Valentino, Maria

Subjects
Mathematics - Number Theory
Abstract

Let F be a global function field of characteristic p>0, K/F an l-adic Lie extension unramified outside a finite set of places S and A/F an abelian variety without complex multiplication. We study Sel_A(K)_l^\vee (the Pontrjagin dual of the Selmer group) and (under some mild hypotheses) prove that it is a finitely generated Z_l[[\Gal(K/F)]]-module via generalizations of Mazur's Control Theorem. If Gal(K/F) has no elements of order l and contains a closed normal subgroup H such that Gal(K/F)/H\simeq Z_l, we are able to give sufficient conditions for Sel_A(K)_l^\vee to be finitely generated as Z_l[[H]]-module and, consequently, a torsion Z_l[[\Gal(K/F)]]-module. We deal with both cases l\neq p and l=p., Comment: 21 pages, revised arguments in sections 2 and 4

Published
2012

25. Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

Author

Giordano, Carla, Iommarini, Luisa, Giordano, Luca, Maresca, Alessandra, Pisano, Annalinda, Valentino, Maria Lucia, Caporali, Leonardo, Liguori, Rocco, Deceglie, Stefania, Roberti, Marina, Fanelli, Francesca, Fracasso, Flavio, Ross-Cisneros, Fred N, D’Adamo, Pio, Hudson, Gavin, Pyle, Angela, Yu-Wai-Man, Patrick, Chinnery, Patrick F, Zeviani, Massimo, Salomao, Solange R, Berezovsky, Adriana, Belfort, Rubens, Ventura, Dora Fix, Moraes, Milton, Filho, Milton Moraes, Barboni, Piero, Sadun, Federico, De Negri, Annamaria, Sadun, Alfredo A, Tancredi, Andrea, Mancini, Massimiliano, d’Amati, Giulia, Polosa, Paola Loguercio, Cantatore, Palmiro, and Carelli, Valerio

Subjects
Biomedical and Clinical Sciences, Health Sciences, Eye Disease and Disorders of Vision, Neurosciences, Genetics, Peripheral Neuropathy, Neurodegenerative, Rare Diseases, Clinical Research, Genetic Testing, Prevention, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Adolescent, Adult, Aged, Aged, 80 and over, DNA, Mitochondrial, Female, Humans, Male, Middle Aged, Mitochondrial Turnover, Optic Atrophy, Hereditary, Leber, Pedigree, Penetrance, Young Adult, LHON penetrance, mitochondrial biogenesis, mtDNA copy number, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Leber's hereditary optic neuropathy is a maternally inherited blinding disease caused as a result of homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. It is characterized by incomplete penetrance, as only some mutation carriers become affected. Thus, the mitochondrial DNA mutation is necessary but not sufficient to cause optic neuropathy. Environmental triggers and genetic modifying factors have been considered to explain its variable penetrance. We measured the mitochondrial DNA copy number and mitochondrial mass indicators in blood cells from affected and carrier individuals, screening three large pedigrees and 39 independently collected smaller families with Leber's hereditary optic neuropathy, as well as muscle biopsies and cells isolated by laser capturing from post-mortem specimens of retina and optic nerves, the latter being the disease targets. We show that unaffected mutation carriers have a significantly higher mitochondrial DNA copy number and mitochondrial mass compared with their affected relatives and control individuals. Comparative studies of fibroblasts from affected, carriers and controls, under different paradigms of metabolic demand, show that carriers display the highest capacity for activating mitochondrial biogenesis. Therefore we postulate that the increased mitochondrial biogenesis in carriers may overcome some of the pathogenic effect of mitochondrial DNA mutations. Screening of a few selected genetic variants in candidate genes involved in mitochondrial biogenesis failed to reveal any significant association. Our study provides a valuable mechanism to explain variability of penetrance in Leber's hereditary optic neuropathy and clues for high throughput genetic screening to identify the nuclear modifying gene(s), opening an avenue to develop predictive genetic tests on disease risk and therapeutic strategies.

Published
2014

27. Stereotactic MR-guided adaptive radiotherapy (SMART) for primary rectal cancer: evaluation of early toxicity and pathological response

Author

Castelluccia, Alessandra, primary, Marchesano, Domenico, additional, Grimaldi, Gianmarco, additional, Annessi, Ivan, additional, Bianciardi, Federico, additional, Borrazzo, Cristian, additional, Dipalma, Annamaria, additional, El Gawhary, Randa, additional, Masi, Marica, additional, Rago, Maria, additional, Valentino, Maria, additional, Verna, Laura, additional, Portaluri, Maurizio, additional, and Gentile, PierCarlo, additional

Published
2023
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28. Secondary post-geniculate involvement in Leber's hereditary optic neuropathy.

Author

Rizzo, Giovanni, Tozer, Kevin R, Tonon, Caterina, Manners, David, Testa, Claudia, Malucelli, Emil, Valentino, Maria Lucia, La Morgia, Chiara, Barboni, Piero, Randhawa, Ruvdeep S, Ross-Cisneros, Fred N, Sadun, Alfredo A, Carelli, Valerio, and Lodi, Raffaele

Subjects
Neurons, Nerve Fibers, Optic Nerve, Humans, Optic Atrophy, Hereditary, Leber, Atrophy, Phenylenediamines, DNA, Mitochondrial, Magnetic Resonance Imaging, Diffusion Magnetic Resonance Imaging, Brain Mapping, Case-Control Studies, Diffusion, Heterozygote, Mutation, Image Processing, Computer-Assisted, Adult, Aged, Middle Aged, Female, Male, Vision, Ocular, DNA, Mitochondrial, Image Processing, Computer-Assisted, Optic Atrophy, Hereditary, Leber, Vision, Ocular, General Science & Technology
Abstract

Leber's hereditary optic neuropathy (LHON) is characterized by retinal ganglion cell (RGC) degeneration with the preferential involvement of those forming the papillomacular bundle. The optic nerve is considered the main pathological target for LHON. Our aim was to investigate the possible involvement of the post-geniculate visual pathway in LHON patients. We used diffusion-weighted imaging for in vivo evaluation. Mean diffusivity maps from 22 LHON visually impaired, 11 unaffected LHON mutation carriers and 22 healthy subjects were generated and compared at level of optic radiation (OR). Prefrontal and cerebellar white matter were also analyzed as internal controls. Furthermore, we studied the optic nerve and the lateral geniculate nucleus (LGN) in post-mortem specimens obtained from a severe case of LHON compared to an age-matched control. Mean diffusivity values of affected patients were higher than unaffected mutation carriers (P

Published
2012

29. The Genetic Puzzle of a SOD1-Patient with Ocular Ptosis and a Motor Neuron Disease: How Many Variants Contribute to the Phenotype?

Author

Vacchiano, Veria, primary, Palombo, Flavia, additional, Ormanbekova, Danara, additional, Fiorini, Claudio, additional, Fiorentino, Alessia, additional, Caporali, Leonardo, additional, Mastrangelo, Andrea, additional, Valentino, Maria Lucia, additional, Capellari, Sabina, additional, Liguori, Rocco, additional, and Carelli, Valerio, additional

Published
2023
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31. A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy

Author

Southwell, Nneka, primary, Primiano, Guido, additional, Nadkarni, Viraj, additional, Attarwala, Nabeel, additional, Beattie, Emelie, additional, Miller, Dawson, additional, Alam, Sumaitaah, additional, Liparulo, Irene, additional, Shurubor, Yevgeniya I, additional, Valentino, Maria Lucia, additional, Carelli, Valerio, additional, Servidei, Serenella, additional, Gross, Steven S, additional, Manfredi, Giovanni, additional, Chen, Qiuying, additional, and D'Aurelio, Marilena, additional

Published
2023
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32. Primary mitochondrial myopathy: Clinical features and outcome measures in 118 cases from Italy

Author

Montano, Vincenzo, Gruosso, Francesco, Carelli, Valerio, Comi, Giacomo Pietro, Filosto, Massimiliano, Lamperti, Costanza, Mongini, Tiziana, Musumeci, Olimpia, Servidei, Serenella, Tonin, Paola, Toscano, Antonio, Modenese, Angela, Primiano, Guido, Valentino, Maria Lucia, Bortolani, Sara, Marchet, Silvia, Meneri, Megi, Tavilla, Graziana, Siciliano, Gabriele, and Mancuso, Michelangelo

Published
2020
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33. Author Correction: Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram Syndrome

Author

La Morgia, Chiara, Maresca, Alessandra, Amore, Giulia, Gramegna, Laura Ludovica, Carbonelli, Michele, Scimonelli, Emanuela, Danese, Alberto, Patergnani, Simone, Caporali, Leonardo, Tagliavini, Francesca, Del Dotto, Valentina, Capristo, Mariantonietta, Sadun, Federico, Barboni, Piero, Savini, Giacomo, Evangelisti, Stefania, Bianchini, Claudio, Valentino, Maria Lucia, Liguori, Rocco, Tonon, Caterina, Giorgi, Carlotta, Pinton, Paolo, Lodi, Raffaele, and Carelli, Valerio

Published
2020
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34. Calcium mishandling in absence of primary mitochondrial dysfunction drives cellular pathology in Wolfram Syndrome

Author

La Morgia, Chiara, Maresca, Alessandra, Amore, Giulia, Gramegna, Laura Ludovica, Carbonelli, Michele, Scimonelli, Emanuela, Danese, Alberto, Patergnani, Simone, Caporali, Leonardo, Tagliavini, Francesca, Del Dotto, Valentina, Capristo, Mariantonietta, Sadun, Federico, Barboni, Piero, Savini, Giacomo, Evangelisti, Stefania, Bianchini, Claudio, Valentino, Maria Lucia, Liguori, Rocco, Tonon, Caterina, Giorgi, Carlotta, Pinton, Paolo, Lodi, Raffaele, and Carelli, Valerio

Published
2020
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35. Administrative Databases and Diagnostic Therapeutic and Assistance Paths -PDTA- in the Monitoring Treatment of Rheumatoid Arthritis: The Experience of ATS Pavia

Author

Bruno, Giacomo M, primary, Valentino, Maria Chiara, additional, Brunetti, Alessandra, additional, Di Matteo, Sergio, additional, Begovic, Ivan, additional, Croce, Edoardo, additional, Sakellariou, Garifallia, additional, Bugatti, Serena, additional, Perotti, Pietro, additional, Vecchio, Silvia, additional, Migliazza, Simona, additional, Langella, Roberto, additional, and Colombo, Giorgio L, additional

Published
2023
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36. Data from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Author

Devy, Laetitia, primary, Huang, Lili, primary, Naa, Laurent, primary, Yanamandra, Niranjan, primary, Pieters, Henk, primary, Frans, Nicolas, primary, Chang, Edward, primary, Tao, Qingfeng, primary, Vanhove, Marc, primary, Lejeune, Annabelle, primary, van Gool, Reinoud, primary, Sexton, Daniel J., primary, Kuang, Guannan, primary, Rank, Douglas, primary, Hogan, Shannon, primary, Pazmany, Csaba, primary, Ma, Yu Lu, primary, Schoonbroodt, Sonia, primary, Nixon, Andrew E., primary, Ladner, Robert C., primary, Hoet, Rene, primary, Henderikx, Paula, primary, TenHoor, Chris, primary, Rabbani, Shafaat A., primary, Valentino, Maria Luisa, primary, Wood, Clive R., primary, and Dransfield, Daniel T., primary

Published
2023
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37. Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Author

Devy, Laetitia, primary, Huang, Lili, primary, Naa, Laurent, primary, Yanamandra, Niranjan, primary, Pieters, Henk, primary, Frans, Nicolas, primary, Chang, Edward, primary, Tao, Qingfeng, primary, Vanhove, Marc, primary, Lejeune, Annabelle, primary, van Gool, Reinoud, primary, Sexton, Daniel J., primary, Kuang, Guannan, primary, Rank, Douglas, primary, Hogan, Shannon, primary, Pazmany, Csaba, primary, Ma, Yu Lu, primary, Schoonbroodt, Sonia, primary, Nixon, Andrew E., primary, Ladner, Robert C., primary, Hoet, Rene, primary, Henderikx, Paula, primary, TenHoor, Chris, primary, Rabbani, Shafaat A., primary, Valentino, Maria Luisa, primary, Wood, Clive R., primary, and Dransfield, Daniel T., primary

Published
2023
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38. Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Author

Devy, Laetitia, primary, Huang, Lili, primary, Naa, Laurent, primary, Yanamandra, Niranjan, primary, Pieters, Henk, primary, Frans, Nicolas, primary, Chang, Edward, primary, Tao, Qingfeng, primary, Vanhove, Marc, primary, Lejeune, Annabelle, primary, van Gool, Reinoud, primary, Sexton, Daniel J., primary, Kuang, Guannan, primary, Rank, Douglas, primary, Hogan, Shannon, primary, Pazmany, Csaba, primary, Ma, Yu Lu, primary, Schoonbroodt, Sonia, primary, Nixon, Andrew E., primary, Ladner, Robert C., primary, Hoet, Rene, primary, Henderikx, Paula, primary, TenHoor, Chris, primary, Rabbani, Shafaat A., primary, Valentino, Maria Luisa, primary, Wood, Clive R., primary, and Dransfield, Daniel T., primary

Published
2023
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39. The Italian reappraisal of the most frequent genetic defects in hereditary optic neuropathies and the global top 10

Author

Fiorini, Claudio, primary, Ormanbekova, Danara, additional, Palombo, Flavia, additional, Carbonelli, Michele, additional, Amore, Giulia, additional, Romagnoli, Martina, additional, d’Agati, Pietro, additional, Valentino, Maria Lucia, additional, Barboni, Piero, additional, Cascavilla, Maria Lucia, additional, De Negri, Annamaria, additional, Sadun, Federico, additional, Carta, Arturo, additional, Testa, Francesco, additional, Petruzzella, Vittoria, additional, Guerriero, Silvana, additional, Bianchi Marzoli, Stefania, additional, Carelli, Valerio, additional, La Morgia, Chiara, additional, and Caporali, Leonardo, additional

Published
2023
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40. The Impact of COVID-19 Pandemic Lockdown on the Relationship between Pediatric MAFLD and Renal Function

Author

Valentino, Maria Sole, primary, Marzuillo, Pierluigi, additional, Esposito, Claudia, additional, Bartiromo, Mario, additional, Nardolillo, Michele, additional, Villani, Annalisa Valentina, additional, Maresca, Alessandro, additional, Furcolo, Giuseppe, additional, Guarino, Stefano, additional, Miraglia del Giudice, Emanuele, additional, and Di Sessa, Anna, additional

Published
2023
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41. Economic Evaluation for Palbociclib Plus Fulvestrant vs Ribociclib Plus Fulvestrant and Abemaciclib Plus Fulvestrant in Endocrine-Resistant Advanced or Metastatic Breast Cancer in Italy

Author

Colombo, Giorgio Lorenzo, primary, Valentino, Maria Chiara, additional, Fabi, Alessandra, additional, Dieci, Maria Vittoria, additional, Caruggi, Mauro, additional, Bruno, Giacomo Matteo, additional, Lombardi, Gloria, additional, and Di Matteo, Sergio, additional

Published
2023
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42. Economic Evaluation for Palbociclib Plus Fulvestrant vs Ribociclib Plus Fulvestrant and Abemaciclib Plus Fulvestrant in Endocrine-Resistant Advanced or Metastatic Breast Cancer in Italy

Author

Colombo,Giorgio Lorenzo, Valentino,Maria Chiara, Fabi,Alessandra, Dieci,Maria Vittoria, Caruggi,Mauro, Bruno,Giacomo Matteo, Lombardi,Gloria, Di Matteo,Sergio, Colombo,Giorgio Lorenzo, Valentino,Maria Chiara, Fabi,Alessandra, Dieci,Maria Vittoria, Caruggi,Mauro, Bruno,Giacomo Matteo, Lombardi,Gloria, and Di Matteo,Sergio

Abstract

Giorgio Lorenzo Colombo,1 Maria Chiara Valentino,2 Alessandra Fabi,3 Maria Vittoria Dieci,4,5 Mauro Caruggi,2 Giacomo Matteo Bruno,2 Gloria Lombardi,6 Sergio Di Matteo2 1Department of Drug Sciences, University of Pavia, Pavia, Italy; 2S.A.V.E. Studi Analisi Valutazioni Economiche S.r.l., Health Economics & Outcomes Research, Milan, Italy; 3Precision Medicine Breast Unit, Scientific Directorate, Department of Women, Children and Public Health Sciences, “A. Gemelli” IRCCS, Roma, Italy; 4Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy; 5Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy; 6Real World Solutions, IQVIA Solutions Italy S.r.l, Milan, ItalyCorrespondence: Giorgio Lorenzo Colombo, Email giorgio.colombo@unipv.itBackground: To date, no study evaluated the cost-effectiveness of palbociclib (PAL) plus fulvestrant (FUL) vs ribociclib (RIB) plus FUL and abemaciclib (ABM) plus FUL in Italy. Cost-effectiveness analysis comparing the three cyclin-dependent 4/6 kinase inhibitors in combination with endocrine therapies for the management of postmenopausal women with HR+, HER2- advanced or metastatic breast cancer in Italy was developed.Material and Methods: To assess the cost-effectiveness of PAL plus FUL vs RIB plus FUL and ABM plus FUL, a cost-minimization has been carried out with a conservative scenario considering three CDK4/6 inhibitors with equal effectiveness in terms of overall survival (OS) (MAIC, Rugo et al 2021). Adverse events (AEs) associated with all therapies were obtained from clinical trials. Ad-hoc analysis was performed to estimate the cost-effectiveness considering the quality-of-life (QoL) data (Lloyd et al 2006).Results: Cost-minimization inputs were drugs, visits and exams, AE monitoring and best supportive care (BSC) before the progression state, active and BSC in the progression and terminal phase of the last two weeks of life. Given the comparability of PAL, RIB and ABM in terms

Published
2023

43. Administrative Databases and Diagnostic Therapeutic and Assistance Paths -PDTA- in the Monitoring Treatment of Rheumatoid Arthritis: The Experience of ATS Pavia

Author

Bruno,Giacomo M, Valentino,Maria Chiara, Brunetti,Alessandra, Di Matteo,Sergio, Begovic,Ivan, Croce,Edoardo, Sakellariou,Garifallia, Bugatti,Serena, Perotti,Pietro, Vecchio,Silvia, Migliazza,Simona, Langella,Roberto, Colombo,Giorgio L, Bruno,Giacomo M, Valentino,Maria Chiara, Brunetti,Alessandra, Di Matteo,Sergio, Begovic,Ivan, Croce,Edoardo, Sakellariou,Garifallia, Bugatti,Serena, Perotti,Pietro, Vecchio,Silvia, Migliazza,Simona, Langella,Roberto, and Colombo,Giorgio L

Abstract

Giacomo M Bruno,1,2 Maria Chiara Valentino,2 Alessandra Brunetti,3 Sergio Di Matteo,2 Ivan Begovic,2 Edoardo Croce,4 Garifallia Sakellariou,5 Serena Bugatti,6 Pietro Perotti,7 Silvia Vecchio,7 Simona Migliazza,7 Roberto Langella,8 Giorgio L Colombo1,2 1Department of Drug Sciences, Center of Pharmaceuticals Economics and Medical Technologies Evaluation, CEFAT.Unipv - University of Pavia at Centro di Ricerca SAVE Studi, Milano, Italy; 2S.A.V.E. Research Center - Studi Analisi Valutazioni Economiche, Milano, Italy; 3Research and Innovation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Scientific Direction - IRCCS istituto Ortopedico Galeazzi, Milan, Italy; 5Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; 6Department of Internal Medicine and Therapeutics, Division of Rheumatology, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 7U.O.C. Epidemiological Observatory – Health Protection Agency of Pavia (ATS Pavia), Pavia, Italy; 8SIFO Regional Secretariat - Società Italiana di Farmacia Ospedaliera e dei Servizi Farmaceutici delle Aziende Sanitarie, Milano, ItalyCorrespondence: Giacomo M Bruno, Department of Drug Sciences, Center of Pharmaceuticals Economics and Medical Technologies Evaluation, CEFAT.Unipv - University of Pavia at Centro di Ricerca SAVE Studi, Milano, 20149, Italy, Email giacomomatteo.bruno@unipv.itBackground: The current flows of the SSN represent the set of interest whose interconnection alone justifies the current study. These flows can be interconnected with other sources, institutional or otherwise, in order to answer well-defined questions.Objective: The objective of the study is to verify, through the analysis of administrative databases, any differences in the consumption of health resources between biological off-patent originator drugs and biosimilars in real clinical practice, with particular reference to the rheumatology area.Methods: Through the use

Published
2023

47. 1320. Incidence and Outcome of Gram Negative Blood Stream Infections in Pediatric Intensive Care Unit: a Real Life Experience in a Pediatric Hospital in Italy

Author

Labate, Laura, primary, Valentino, Maria Sole, additional, Bigatti, Carolina, additional, Medici, Chiara, additional, Palmero, Candida, additional, Losurdo, Giuseppe, additional, Cristina, Emilio, additional, Mariani, Marcello, additional, Ugolotti, Elisabetta, additional, Franceschi, Alessia, additional, Russo, Chiara, additional, Tavella, Elisa, additional, Bondi, Elisabetta, additional, Montalto, Shana, additional, Ricci, Erica, additional, Moscatelli, Andrea, additional, Castagnola, Elio, additional, and Mesini, Alessio, additional

Published
2022
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48. Repression of autocrine pheromone signaling leads to fusaric acid over-production

Author

Staropoli, Alessia, Guastaferro, Valentino Maria, Vinale, Francesco, Turra, David, Di Costanzo, Luigi, and Vitale, Stefania

Abstract

Fusaric acid (FA), a picolinic acid derivative, is a natural substance produced by a wide variety of fungal plant pathogens belonging to the Fusarium genus. As a metabolite, fusaric acid exerts several biological activities including metal chelation, electrolyte leakage, repression of ATP synthesis, and direct toxicity on plants, animals and bacteria. Prior studies on the structure of fusaric acid revealed a co-crystal dimeric adduct between FA and 9,10-dehydrofusaric acid. During an ongoing search for signaling genes differentially regulating FA production in the fungal pathogen Fusarium oxysporum (Fo), we found that mutants lacking pheromone expression have an increased production of FA compared to the wild type strain. Noteworthy, crystallographic analysis of FA extracted from Fo culture supernatants showed that crystals are formed by a dimeric form of two FA molecules (1:1 molar stoichiometry). Overall, our results suggest that pheromone signaling in Fo is required to regulate the synthesis of fusaric acid.

Published
2023
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49. Co-occurrence of amyotrophic lateral sclerosis and Leber’s hereditary optic neuropathy: is mitochondrial dysfunction a modifier?

Author

Amore, Giulia, primary, Vacchiano, Veria, additional, La Morgia, Chiara, additional, Valentino, Maria L., additional, Caporali, Leonardo, additional, Fiorini, Claudio, additional, Ormanbekova, Danara, additional, Salvi, Fabrizio, additional, Bartoletti-Stella, Anna, additional, Capellari, Sabina, additional, Liguori, Rocco, additional, and Carelli, Valerio, additional

Published
2022
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50. Capturing the Pattern of Transition From Carrier to Affected in Leber Hereditary Optic Neuropathy

Author

Carbonelli, Michele, primary, La Morgia, Chiara, additional, Romagnoli, Martina, additional, Amore, Giulia, additional, D'Agati, Pietro, additional, Valentino, Maria Lucia, additional, Caporali, Leonardo, additional, Cascavilla, Maria Lucia, additional, Battista, Marco, additional, Borrelli, Enrico, additional, Di Renzo, Antonio, additional, Parisi, Vincenzo, additional, Balducci, Nicole, additional, Carelli, Valerio, additional, and Barboni, Piero, additional

Published
2022
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