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1. Quantitative Analysis of Paleomagnetic Sampling Strategies

Author

Sapienza, F, Gallo, LC, Zhang, Y, Vaes, B, Domeier, M, and Swanson‐Hysell, NL

Subjects
Earth Sciences, Geology, Generic health relevance, paleomagnetism, paleopole estimation, secular variation, error quantification, Geochemistry, Geophysics
Abstract

Sampling strategies used in paleomagnetic studies play a crucial role in dictating the accuracy of our estimates of properties of the ancient geomagnetic field. However, there has been little quantitative analysis of optimal paleomagnetic sampling strategies and the community has instead defaulted to traditional practices that vary between laboratories. In this paper, we quantitatively evaluate the accuracy of alternative paleomagnetic sampling strategies through numerical experiments and an associated analytical framework. Our findings demonstrate a strong correspondence between the accuracy of an estimated paleopole position and the number of sites or independent readings of the time-varying paleomagnetic field, whereas larger numbers of in-site samples have a dwindling effect. This remains true even when a large proportion of the sample directions are spurious. This approach can be readily achieved in sedimentary sequences by distributing samples stratigraphically, considering each sample as an individual site. However, where the number of potential independent sites is inherently limited the collection of additional in-site samples can improve the accuracy of the paleopole estimate (although with diminishing returns with increasing samples per site). Where an estimate of the magnitude of paleosecular variation is sought, multiple in-site samples should be taken, but the optimal number is dependent on the expected fraction of outliers. The use of filters based on angular distance helps the accuracy of paleopole estimation, but leads to inaccurate estimates of paleosecular variation. We provide both analytical formulas and a series of interactive Jupyter notebooks allowing optimal sampling strategies to be developed from user-informed expectations.

Published
2023

2. Embracing Uncertainty to Resolve Polar Wander: A Case Study of Cenozoic North America

Author

Gallo, LC, Domeier, M, Sapienza, F, Swanson‐Hysell, NL, Vaes, B, Zhang, Y, Arnould, M, Eyster, A, Gürer, D, Király, Á, Robert, B, Rolf, T, Shephard, G, and van der Boon, A

Subjects
Earth Sciences, Geochemistry, Geology, Geophysics, paleomagnetism, polar wander, uncertainty quantification, Meteorology & Atmospheric Sciences
Abstract

Our understanding of Earth's paleogeography relies heavily on paleomagnetic apparent polar wander paths (APWPs), which represent the time-dependent position of Earth's spin axis relative to a given block of lithosphere. However, conventional approaches to APWP construction have significant limitations. First, the paleomagnetic record contains substantial noise that is not integrated into APWPs. Second, parametric assumptions are adopted to represent spatial and temporal uncertainties even where the underlying data do not conform to the assumed distributions. The consequences of these limitations remain largely unknown. Here, we address these challenges with a bottom-up Monte Carlo uncertainty propagation scheme that operates on site-level paleomagnetic data. To demonstrate our methodology, we present an extensive compilation of site-level Cenozoic paleomagnetic data from North America, which we use to generate a high-resolution APWP. Our results demonstrate that even in the presence of substantial noise, polar wandering can be assessed with unprecedented temporal and spatial resolution.

Published
2023

6. Delivery of multipotent adult progenitor cells via a functionalized plasma polymerized surface accelerates healing of murine diabetic wounds

Author

Mills, S. J., Kirby, G. T., Hofma, B. R., Smith, L. E., Statham, P., Vaes, B., Ting, A. E., Short, R., Cowin, A. J., Mills, S. J., Kirby, G. T., Hofma, B. R., Smith, L. E., Statham, P., Vaes, B., Ting, A. E., Short, R., and Cowin, A. J.

Abstract

Introduction: Stem cell therapies have been investigated as potential treatment modalities for chronic wounds however there has been limited success to date. Multipotent Adult Progenitor Cells (MAPCs©) have been identified as having potential as an allogenic stem cell product due to their high population doubling number and their characteristic dampening of T-cell proliferation. This helps to prevent autoimmunity and graft/cell rejection. Methods: We have developed a dressing, consisting of medical grade silicone coated with a heptylamine plasma polymer, which supports the growth and transfer of MAPCs to skin. To determine if the dressing can deliver functional stem cells into diabetic wounds, they were loaded with MAPCs and then placed over excisional wounds in both normal and diabetic mice. Results and discussion: Accelerated healing was observed in both the normal and diabetic wounds with wound gape being significantly smaller at day 3 when compared to controls. Wound analysis showed that treatment with the MAPC dressings dampened the inflammatory response with reduced numbers of neutrophils and macrophages observed. Additionally, an increase in pro-angiogenic VEGF and CD31 positive endothelial cells was observed indicating improved new blood vessel formation. The MAPC dressings had no effect on fibrosis with collagen I and III being equally affected in both control and treated wounds. Overall, the functionalized MAPC dressings improve healing responses particularly in diabetic mice with impaired healing responses and therefore, show potential for development as an advanced therapeutic approach for the treatment of chronic diabetic wounds.

Published
2023

7. The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis

Author

Xu, Y.F., Derakhshan, A., Hysaj, O., Wildisen, L., Ittermann, T., Pingitore, A., Abolhassani, N., Medici, M., Kiemeney, L.A., Riksen, N.P., Dullaart, R.P.F., Trompet, S., Dörr, M., Brown, S.J., Schmidt, Börge, Führer-Sakel, D., Vanderpump, M.P.J., Muendlein, A., Drexel, H., Fink, H.A., Ikram, M.K., Kavousi, M., Rhee, C.M., Bensenor, I.M., Azizi, F., Hankey, G.J., Iacoviello, M., Imaizumi, M., Ceresini, G., Ferrucci, L., Sgarbi, J.A., Bauer, D.C., Wareham, N., Boelaert, K., Bakker, S.J.L., Jukema, J.W., Vaes, B., Iervasi, G., Yeap, B.B., Westendorp, R.G.J., Korevaar, T.I.M., Völzke, H., Razvi, S., Gussekloo, J., Walsh, J.P., Cappola, A.R., Rodondi, N., Peeters, R.P., Chaker, L., Xu, Y.F., Derakhshan, A., Hysaj, O., Wildisen, L., Ittermann, T., Pingitore, A., Abolhassani, N., Medici, M., Kiemeney, L.A., Riksen, N.P., Dullaart, R.P.F., Trompet, S., Dörr, M., Brown, S.J., Schmidt, Börge, Führer-Sakel, D., Vanderpump, M.P.J., Muendlein, A., Drexel, H., Fink, H.A., Ikram, M.K., Kavousi, M., Rhee, C.M., Bensenor, I.M., Azizi, F., Hankey, G.J., Iacoviello, M., Imaizumi, M., Ceresini, G., Ferrucci, L., Sgarbi, J.A., Bauer, D.C., Wareham, N., Boelaert, K., Bakker, S.J.L., Jukema, J.W., Vaes, B., Iervasi, G., Yeap, B.B., Westendorp, R.G.J., Korevaar, T.I.M., Völzke, H., Razvi, S., Gussekloo, J., Walsh, J.P., Cappola, A.R., Rodondi, N., Peeters, R.P., and Chaker, L.

Abstract

Contains fulltext : 297328.pdf (Publisher’s version ) (Closed access), BACKGROUND: Reference intervals of thyroid-stimulating hormone (TSH) and free thyroxine (FT(4)) are statistically defined by the 2·5-97·5th percentiles, without accounting for potential risk of clinical outcomes. We aimed to define the optimal healthy ranges of TSH and FT(4) based on the risk of cardiovascular disease and mortality. METHODS: This systematic review and individual participant data (IPD) meta-analysis identified eligible prospective cohorts through the Thyroid Studies Collaboration, supplemented with a systematic search via Embase, MEDLINE (Ovid), Web of science, the Cochrane Central Register of Controlled Trials, and Google Scholar from Jan 1, 2011, to Feb 12, 2017 with an updated search to Oct 13, 2022 (cohorts found in the second search were not included in the IPD). We included cohorts that collected TSH or FT(4), and cardiovascular outcomes or mortality for adults (aged ≥18 years). We excluded cohorts that included solely pregnant women, individuals with overt thyroid diseases, and individuals with cardiovascular disease. We contacted the study investigators of eligible cohorts to provide IPD on demographics, TSH, FT(4), thyroid peroxidase antibodies, history of cardiovascular disease and risk factors, medication use, cardiovascular disease events, cardiovascular disease mortality, and all-cause mortality. The primary outcome was a composite outcome including cardiovascular disease events (coronary heart disease, stroke, and heart failure) and all-cause mortality. Secondary outcomes were the separate assessment of cardiovascular disease events, all-cause mortality, and cardiovascular disease mortality. We performed one-step (cohort-stratified Cox models) and two-step (random-effects models) meta-analyses adjusting for age, sex, smoking, systolic blood pressure, diabetes, and total cholesterol. The study was registered with PROSPERO, CRD42017057576. FINDINGS: We identified 3935 studies, of which 53 cohorts fulfilled the inclusion criteria and 26 co

Published
2023

8. The wandering pole: tracing the time-averaged paleomagnetic pole in the face of secular variation

Author

Vaes, B.

Abstract

Paleomagnetism serves as the principal tool for the quantitative reconstruction of Earth’s paleogeography, thereby providing key input for geodynamics, paleoclimatology and paleobiology. Paleomagnetic data have been used for >60 years to quantify the apparent motion of the time-averaged paleomagnetic pole relative to a fixed continent or tectonic plate through time. By assuming that the time-averaged geomagnetic pole coincides with the Earth’s spin axis, this polar motion can be translated into the motion of a continent or plate relative to the geographic pole. However, obtaining a reliable estimate of the time-averaged pole position requires the averaging of the short-term, secular variation of Earth’s magnetic field. Here, I show that coeval paleomagnetic poles derived from datasets underrepresenting paleosecular variation or based on a smaller number of paleomagnetic sites are more dispersed and often biased compared to poles that adequately sample secular variation. This reveals that the degree to which paleosecular variation is averaged is an important contributor to uncertainties and bias in estimates of the paleomagnetic pole position. Moreover, the most widely used method to correct sediment-derived paleomagnetic poles for the notorious problem of inclination shallowing relies on both a model of paleosecular variation as well as on the assumption that secular variation is adequately represented by the dataset. In this study, I highlight the importance of a thorough understanding of secular variation throughout geological time for the use of paleomagnetism as a quantitative tool for the reconstruction of paleogeography., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023
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13. Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies

Author

Syrogiannouli, L., Wildisen, L., Meuwese, C., Bauer, D.C., Cappola, A.R., Gussekloo, J., Elzen, W.P.J. den, Trompet, S., Westendorp, R.G.J., Jukema, J.W., Ferrucci, L., Ceresini, G., Asvold, B.O., Chaker, L., Peeters, R.P., Imaizumi, M., Ohishi, W., Vaes, B., Volzke, H., Sgarbi, J.A., Walsh, J.P., Dullaart, R.P.F., Bakker, S.J.L., Iacoviello, M., Rodondi, N., Giovane, C. del, Thyroid Studies Collaboration, Epidemiology, Internal Medicine, Laboratory for Endocrinology, APH - Personalized Medicine, APH - Aging & Later Life, Groningen Institute for Organ Transplantation (GIOT), and Groningen Kidney Center (GKC)

Subjects
baseline imbalance, cohorts, continuous outcome, individual participant data, non-randomized studies, Prevention, Clinical Sciences, 360 Soziale Probleme, Sozialdienste, 610 Medicine & health, Psychiatry and Mental health, SDG 3 - Good Health and Well-being, 360 Social problems & social services, Public Health and Health Services, Psychology, 610 Medizin und Gesundheit
Abstract

BackgroundIn non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure group and control group. This may bias the study and consequently a meta-analysis (MA) estimate. These estimates may differ across statistical methods used to deal with this issue. Analysis of individual participant data (IPD) allows standardization of methods across studies. We aimed to identify methods used in published IPD-MAs of NRSs for continuous outcomes, and to compare different methods to account for baseline values of outcome variables in IPD-MA of NRSs using two empirical examples from the Thyroid Studies Collaboration (TSC).MethodsFor the first aim we systematically searched in MEDLINE, EMBASE, and Cochrane from inception to February 2021 to identify published IPD-MAs of NRSs that adjusted for baseline outcome measures in the analysis of continuous outcomes. For the second aim, we applied analysis of covariance (ANCOVA), change score, propensity score and the naïve approach (ignores the baseline outcome data) in IPD-MA from NRSs on the association between subclinical hyperthyroidism and depressive symptoms and renal function. We estimated the study and meta-analytic mean difference (MD) and relative standard error (SE). We used both fixed- and random-effects MA.ResultsTen of 18 (56%) of the included studies used the change score method, seven (39%) studies used ANCOVA and one the propensity score (5%). The study estimates were similar across the methods in studies in which groups were balanced at baseline with regard to outcome variables but differed in studies with baseline imbalance. In our empirical examples, ANCOVA and change score showed study results on the same direction, not the propensity score. In our applications, ANCOVA provided more precise estimates, both at study and meta-analytical level, in comparison to other methods. Heterogeneity was higher when change score was used as outcome, moderate for ANCOVA and null with the propensity score.ConclusionANCOVA provided the most precise estimates at both study and meta-analytic level and thus seems preferable in the meta-analysis of IPD from non-randomized studies. For the studies that were well-balanced between groups, change score, and ANCOVA performed similarly.

Published
2022
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14. The effect of automated audit and feedback on data completeness in the electronic health record of the general physician: protocol for a cluster randomized controlled trial

Author

Bulck, S.A. van den, Burghgraeve, Tine De, Raat, Willem, Mamouris, P., Coursier, Patrick, Vankrunkelsven, P., Hermens, R.P., Pottelbergh, Gijs Van, Vaes, B., Bulck, S.A. van den, Burghgraeve, Tine De, Raat, Willem, Mamouris, P., Coursier, Patrick, Vankrunkelsven, P., Hermens, R.P., Pottelbergh, Gijs Van, and Vaes, B.

Abstract

Contains fulltext : 234225.pdf (Publisher’s version ) (Open Access)

Published
2021

15. Subduction initiation in the Scotia Sea region and opening of the Drake Passage: When and why?

Author

Van de Lagemaat, S.H.A., Swart, M.L.A., Vaes, B., Kosters, M.E., Boschman, L.M., Burton-Johnson, A., Bijl, P.K., Spakman, W., van Hinsbergen, D.J.J., Van de Lagemaat, S.H.A., Swart, M.L.A., Vaes, B., Kosters, M.E., Boschman, L.M., Burton-Johnson, A., Bijl, P.K., Spakman, W., and van Hinsbergen, D.J.J.

Abstract

During evolution of the South Sandwich subduction zone, which has consumed South American Plate oceanic lithosphere, somehow continental crust of both the South American and Antarctic plates have become incorporated into its upper plate. Continental fragments of both plates are currently separated by small oceanic basins in the upper plate above the South Sandwich subduction zone, in the Scotia Sea region, but how fragments of both continents became incorporated in the same upper plate remains enigmatic. Here we present an updated kinematic reconstruction of the Scotia Sea region using the latest published marine magnetic anomaly constraints, and place this in a South America-Africa-Antarctica plate circuit in which we take intracontinental deformation into account. We show that a change in marine magnetic anomaly orientation in the Weddell Sea requires that previously inferred initiation of subduction of South American oceanic crust of the northern Weddell Sea below the eastern margin of South Orkney Islands continental crust, then still attached to the Antarctic Peninsula, already occurred around 80 Ma. Subsequently, between ~71–50 Ma, we propose that the trench propagated northwards into South America by delamination of South American lithosphere: this resulted in the transfer of delaminated South American continental crust to the overriding plate of the South Sandwich subduction zone. We show that continental delamination may have been facilitated by absolute southward motion of South America that was resisted by South Sandwich slab dragging. Pre-drift extension preceding the oceanic Scotia Sea basins led around 50 Ma to opening of the Drake Passage, preconditioning the southern ocean for the Antarctic Circumpolar Current. This 50 Ma extension was concurrent with a strong change in absolute plate motion of the South American Plate that changed from S to WNW, leading to upper plate retreat relative to the more or less mantle stationary South Sandwich Trench that

Published
2021

16. Cardiologists' perceptions on multidisciplinary collaboration in heart failure care - a qualitative study

Author

Raat, W, Smeets, M, Vandewal, I, Broekx, L, Peters, S, Janssens, S, Vaes, B, Aertgeerts, B, Raat, W, Smeets, M, Vandewal, I, Broekx, L, Peters, S, Janssens, S, Vaes, B, and Aertgeerts, B

Abstract

BACKGROUND: Cardiologists play a key role in multidisciplinary care by guiding heart failure (HF) management in the hospital and in the community. Regional implementation of multidisciplinary health care interventions depends on how they perceive collaboration with other health care disciplines, yet research on this topic is limited. This study aimed to explore the views and opinions of cardiologists on multidisciplinary collaboration in HF care. METHODS: We conducted a qualitative study based on face-to-face semi-structured interviews with 11 Belgian cardiologists between September 2019 and February 2020. We used the Qualitative Analysis Guide of Leuven (QUAGOL) method as guidance for data analysis until data saturation was reached. RESULTS: Cardiologists consider the general practitioner (GP) and HF nurse as the most important partners in HF management. Cardiologists identified four problems in current multidisciplinary collaboration: the communication of a HF diagnosis to the patient, advanced care planning, titration of HF medication by the GP and electronic data exchange and communication. Three themes emerged as ideas for improvement of HF care: 1) expansion of the role of the HF nurse, 2) implementation of a structured, patient-centered, and flexible model of disease management program and 3) integrated data approaches. CONCLUSION: Cardiologists value close cooperation with GPs in HF management. They advocate an expanded future role for the HF nurse, increased eHealth, and structured disease management to optimize current HF care.

Published
2021

17. Erratum: stematic review and meta-analysis of individual participant data (Clin Epidemiol. 2018, 10, 363–379)

Author

Eurelings L. S. M., van Dalen J. W., Ter Riet G., Moll van Charante E. P., Richard E., van Gool W. A., Almeida O. P., Alexandre T. S., Baune B. T., Bickel H., Cacciatore F., Cooper C., de Craen T. A. J. M., Degryse J. -M., Di Bari M., Duarte Y. A., Feng L., Ferrara N., Flicker L., Gallucci M., Guaita A., Harrison S. L., Katz M. J., Lebrao M. L., Leung J., Lipton R. B., Mengoni M., Ng T. P., Ostbye T., Panza F., Polito L., Sander D., Solfrizzi V., Syddall H. E., van der Mast R. C., Vaes B., Woo J., Yaffe K., Gao S., Ho S. C., Lindsay J., Sham A., Reppermund S., Unverzagt F. W., Eurelings, L. S. M., van Dalen, J. W., Ter Riet, G., Moll van Charante, E. P., Richard, E., van Gool, W. A., Almeida, O. P., Alexandre, T. S., Baune, B. T., Bickel, H., Cacciatore, F., Cooper, C., de Craen, T. A. J. M., Degryse, J. -M., Di Bari, M., Duarte, Y. A., Feng, L., Ferrara, N., Flicker, L., Gallucci, M., Guaita, A., Harrison, S. L., Katz, M. J., Lebrao, M. L., Leung, J., Lipton, R. B., Mengoni, M., Ng, T. P., Ostbye, T., Panza, F., Polito, L., Sander, D., Solfrizzi, V., Syddall, H. E., van der Mast, R. C., Vaes, B., Woo, J., Yaffe, K., Gao, S., Ho, S. C., Lindsay, J., Sham, A., Reppermund, S., and Unverzagt, F. W.

Abstract

Page 363, affiliations section, “On behalf of the ICARA Study Group” should instead read “and the ICARA study group”.

Published
2019

18. Towards FAIR paleomagnetic data management through Paleomagnetism.org 2.0

Author

Koymans, M.R., van Hinsbergen, D.J.J., Pastor‐Galan, D., Vaes, B., Langereis, C.G., Paleomagnetism, Mantle dynamics & theoretical geophysics, Paleomagnetism, and Mantle dynamics & theoretical geophysics

Subjects
010504 meteorology & atmospheric sciences, analysis, Data management, 010502 geochemistry & geophysics, computer.software_genre, 01 natural sciences, Software, Geochemistry and Petrology, 0105 earth and related environmental sciences, FAIR, business.industry, Magic (programming), paleomagnetism, Data science, Variety (cybernetics), data library, Data sharing, Geophysics, Workflow, Section (archaeology), statistics, Paleomagnetism.org, Web service, business, computer, Geology
Abstract

Scientific communities are placing an increasing emphasis on the implementation of data management protocols concerning data archiving and distribution. For instance, every proposal submitted to the European Horizon 2020 program, as well as to the National Science Foundation in the USA, requires a dedicated section that outlines project data management and accessibility. The widely adopted FAIR data guidelines identify core principles concerning modern data management conventions. The wide variety of data formats, the low data volume, and the general lack of a culture of data sharing makes that the paleomagnetic community rarely follows any of the FAIR principles. Most institutions define their own data formats and use in‐house software to analyze their demagnetization data, which are critical to Paleomagnetic research. Efforts to overcome these problems exist in the form of the MagIC database for data archiving, and the online paleomagnetic data analysis and interpretation platform Paleomagnetism.org. In this contribution, we describe the second iteration of Paleomagnetism.org: an online multiplatform open‐source environment for paleomagnetic data analysis. This update comprises a full overhaul of the application to satisfy the increasingly demanding data management requirements. The application now facilitates a workflow that aligns with FAIR guidelines by documenting data provenance. All data analyzed through the application are easily submitted to a public data library that distributes data and results through an HTTPS web service that lives up to modern data management standards.

Published
2020

19. Epidemiology of knee osteoarthritis in general practice: a registry-based study

Author

Spitaels, D., Mamouris, P., Vaes, B., Smeets, M., Luyten, F., Hermens, R.P., Vankrunkelsven, P., Spitaels, D., Mamouris, P., Vaes, B., Smeets, M., Luyten, F., Hermens, R.P., and Vankrunkelsven, P.

Abstract

Contains fulltext : 218861.pdf (publisher's version ) (Open Access), OBJECTIVES: The present study investigated (1) trends in the prevalence and incidence of knee osteoarthritis over a 20-year period (1996-2015); (2) trends in multimorbidity and (3) trends in drug prescriptions. DESIGN: Registry-based study. SETTING: Primary healthcare, Flanders, Belgium. PARTICIPANTS: Data were collected from Intego, a general practice-based morbidity registration network. In the study period between 1996 and 2015, data from 440 140 unique patients were available. OUTCOME MEASURES: Trends in prevalence and incidence rate of knee osteoarthritis were computed using joinpoint regression analysis. The mean disease count was calculated to assess trends in multimorbidity. In addition, the number of drug prescriptions was identified by the Anatomical Therapeutic Chemical Classification code and trends were equally recorded with joinpoint regression. RESULTS: The total age-standardised prevalence of knee osteoarthritis increased from 2.0% in 1996 to 3.6% in 2015. An upward trend was observed with an average annual percentage change (AAPC) of 2.5 (95% CI 2.2 to 2.9). In 2015, the prevalence rates in the 10 year age groups from the 45-54 years age group onwards were 3.1%, 5.6%, 9.0% and 13.9%, to reach 15.0% in people aged 85 years and older. The incidence remained stable with 3.75 per thousand in 2015 (AAPC=-0.5, 95% CI -1.4 to 0.5). The mean disease count significantly increased from 1.63 to 2.34 (p<0.001) for incident cases with knee osteoarthritis. Finally, we observed a significantly positive trend in the overall prescription of acetaminophen (AAPC=6.7, 95% CI 5.6 to 7.7), weak opioids (AAPC=4.0, 95% CI 0.9 to 7.3) and glucosamine (AAPC=8.6, 95% CI 2.4 to 15.1). Oral non-steroidal anti-inflammatory drugs were most prescribed, with a prevalence rate of 29.8% in 2015, but remained stable during the study period (AAPC=0.0, 95% CI -1.1 to 1.1). CONCLUSIONS: Increased prevalence, multimorbidity, and number of drug prescriptions confirm an increased burden of

Published
2020

20. The effect of electronic audits and feedback in primary care and factors that contribute to their effectiveness: a systematic review

Author

Bulck, S. Van Den, Spitaels, D., Vaes, B., Goderis, G., Hermens, R.P., Vankrunkelsven, P., Bulck, S. Van Den, Spitaels, D., Vaes, B., Goderis, G., Hermens, R.P., and Vankrunkelsven, P.

Abstract

Contains fulltext : 229519.pdf (Publisher’s version ) (Closed access), The aim of this systematic review was (i) to assess whether electronic audit and feedback (A&F) is effective in primary care and (ii) to evaluate important features concerning content and delivery of the feedback in primary care, including the use of benchmarks, the frequency of feedback, the cognitive load of feedback and the evidence-based aspects of the feedback.The MEDLINE, Embase, CINAHL and CENTRAL databases were searched for articles published since 2010 by replicating the search strategy used in the last Cochrane review on A&F.Two independent reviewers assessed the records for their eligibility, performed the data extraction and evaluated the risk of bias. Our search resulted in 8744 records, including the 140 randomized controlled trials (RCTs) from the last Cochrane Review. The full texts of 431 articles were assessed to determine their eligibility. Finally, 29 articles were included.Two independent reviewers extracted standard data, data on the effectiveness and outcomes of the interventions, data on the kind of electronic feedback (static versus interactive) and data on the aforementioned feedback features.Twenty-two studies (76%) showed that electronic A&F was effective. All interventions targeting medication safety, preventive medicine, cholesterol management and depression showed an effect. Approximately 70% of the included studies used benchmarks and high-quality evidence in the content of the feedback. In almost half of the studies, the cognitive load of feedback was not reported. Due to high heterogeneity in the results, no meta-analysis was performed.This systematic review included 29 articles examining electronic A&F interventions in primary care, and 76% of the interventions were effective. Our findings suggest electronic A&F is effective in primary care for different conditions such as medication safety and preventive medicine. Some of the benefits of electronic A&F include its scalability and the potential to be cost ef

Published
2020

21. Towards FAIR paleomagnetic data management through Paleomagnetism.org 2.0

Author

Paleomagnetism, Mantle dynamics & theoretical geophysics, Koymans, M.R., van Hinsbergen, D.J.J., Pastor‐Galan, D., Vaes, B., Langereis, C.G., Paleomagnetism, Mantle dynamics & theoretical geophysics, Koymans, M.R., van Hinsbergen, D.J.J., Pastor‐Galan, D., Vaes, B., and Langereis, C.G.

Published
2020

22. Towards FAIR Paleomagnetic Data Management Through Paleomagnetism.org 2.0

Author

Netherlands Organization for Scientific Research, 0000-0002-6250-2474, 0000-0003-3410-0344, 0000-0002-0226-2739, 0000-0001-6062-6804, 0000-0001-9232-2178, Koymans, M. R., van Hinsbergen, D. J.J., Pastor-Galán, D., Vaes, B., Langereis, C. G., Netherlands Organization for Scientific Research, 0000-0002-6250-2474, 0000-0003-3410-0344, 0000-0002-0226-2739, 0000-0001-6062-6804, 0000-0001-9232-2178, Koymans, M. R., van Hinsbergen, D. J.J., Pastor-Galán, D., Vaes, B., and Langereis, C. G.

Abstract

Scientific communities are placing an increasing emphasis on the implementation of data management protocols concerning data archiving and distribution. For instance, every proposal submitted to the European Horizon 2020 program, as well as to the National Science Foundation in the USA, requires a dedicated section that outlines project data management and accessibility. The widely adopted FAIR data guidelines identify core principles concerning modern data management conventions. The wide variety of data formats, the low data volume, and the general lack of a culture of data sharing makes that the paleomagnetic community rarely follows any of the FAIR principles. Most institutions define their own data formats and use in-house software to analyze their demagnetization data, which are critical to Paleomagnetic research. Efforts to overcome these problems exist in the form of the MagIC database for data archiving, and the online paleomagnetic data analysis and interpretation platform Paleomagnetism.org. In this contribution, we describe the second iteration of Paleomagnetism.org: an online multiplatform open-source environment for paleomagnetic data analysis. This update comprises a full overhaul of the application to satisfy the increasingly demanding data management requirements. The application now facilitates a workflow that aligns with FAIR guidelines by documenting data provenance. All data analyzed through the application are easily submitted to a public data library that distributes data and results through an HTTPS web service that lives up to modern data management standards.

Published
2020

24. AB1153 ANALGESIC AND ANTI-INFLAMMATORY DRUG USE IN PATIENTS WITH RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS AND SPONDYLOARTHRITIS VERSUS CONTROLS IN A BELGIAN GENERAL PRACTITIONER REGISTRY.

Author

Pazmino, S., primary, Stouten, V., additional, Verschueren, P., additional, Mamouris, P., additional, Westhovens, R., additional, De Vlam, K., additional, Bertrand, D., additional, Van der Elst, K., additional, Vaes, B., additional, and De Cock, D., additional

Published
2020
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27. Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries

Author

Ploeg, M.A., Streit, S., Achterberg, W.P., Beers, E., Bohnen, A.M., Burman, R.A., Collins, C., Franco, F.G., Gerasimovska-Kitanovska, B., Gintere, S., Bravo, R. Gomez, Hoffmann, K., Iftode, C., Pestic, S.K., Koskela, T.H., Kurpas, D., Maisonneuve, H., Mallen, C.D., Merlo, C., Mueller, Y., Muth, C., Petrazzuoli, F., Rodondi, N., Rosemann, T., Sattler, M., Schermer, T.R., Ster, M.P., Svadlenkova, Z., Tatsioni, A., Thulesius, H., Tkachenko, V., Torzsa, P., Tsopra, R., Tuz, C., Vaes, B., Viegas, R.P.A., Vinker, S., Wallis, K.A., Zeller, A., Gussekloo, J., Poortvliet, R.K.E., Ploeg, M.A., Streit, S., Achterberg, W.P., Beers, E., Bohnen, A.M., Burman, R.A., Collins, C., Franco, F.G., Gerasimovska-Kitanovska, B., Gintere, S., Bravo, R. Gomez, Hoffmann, K., Iftode, C., Pestic, S.K., Koskela, T.H., Kurpas, D., Maisonneuve, H., Mallen, C.D., Merlo, C., Mueller, Y., Muth, C., Petrazzuoli, F., Rodondi, N., Rosemann, T., Sattler, M., Schermer, T.R., Ster, M.P., Svadlenkova, Z., Tatsioni, A., Thulesius, H., Tkachenko, V., Torzsa, P., Tsopra, R., Tuz, C., Vaes, B., Viegas, R.P.A., Vinker, S., Wallis, K.A., Zeller, A., Gussekloo, J., and Poortvliet, R.K.E.

Abstract

Contains fulltext : 208370.pdf (publisher's version ) (Open Access), BACKGROUND: Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners' (GPs) advice to stop statins in oldest-old patients. OBJECTIVE: To investigate the influence of a history of CVD, statin-related side effects, frailty and short life expectancy, on GPs' advice to stop statins in oldest-old patients. DESIGN: We invited GPs to participate in this case-based survey. GPs were presented with 8 case vignettes describing patients > 80 years using a statin, and asked whether they would advise stopping statin treatment. MAIN MEASURES: Cases varied in history of CVD, statin-related side effects and frailty, with and without shortened life expectancy (< 1 year) in the context of metastatic, non-curable cancer. Odds ratios adjusted for GP characteristics (ORadj) were calculated for GPs' advice to stop. KEY RESULTS: Two thousand two hundred fifty GPs from 30 countries participated (median response rate 36%). Overall, GPs advised stopping statin treatment in 46% (95%CI 45-47) of the case vignettes; with shortened life expectancy, this proportion increased to 90% (95CI% 89-90). Advice to stop was more frequent in case vignettes without CVD compared to those with CVD (ORadj 13.8, 95%CI 12.6-15.1), with side effects compared to without ORadj 1.62 (95%CI 1.5-1.7) and with frailty (ORadj 4.1, 95%CI 3.8-4.4) compared to without. Shortened life expectancy increased advice to stop (ORadj 50.7, 95%CI 45.5-56.4) and was the strongest predictor for GP advice to stop, ranging across countries from 30% (95%CI 19-42) to 98% (95% CI 96-99). CONCLUSIONS: The absence of CVD, the presence of statin-related side effects, and frailty were all independently associated with GPs' advice to stop statins in patients aged > 80 years. Overall, and within all countries, cancer-related short life expectancy was the strongest independent predictor of GPs' advice

Published
2019

28. Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries

Author

Ploeg, M.A. (Milly) van der, Streit, S., Achterberg, W.P., Beers, E., Bohnen, A.M. (Arthur), Burman, R.A., Collins, C. (Colin), Franco, F.G., Gerasimovska-Kitanovska, B., Gintere, S., Bravo, R.G., Hoffmann, K., Iftode, C., Pestic, S.K., Koskela, T.H., Kurpas, D., Maisonneuve, H., Mallen, C.D., Merlo, C., Mueller, Y., Muth, C., Petrazzuoli, F., Rodondi, N, Rosemann, T., Sattler, M., Schermer, T., Ster, M.P., Svadlenkova, Z., Tatsioni, A., Thulesius, H., Tkachenko, V. (Valery), Torzsa, P., Tsopra, R., Tuz, C., Vaes, B., Viegas, R.P.A., Vinker, S., Wallis, K.A., Zeller, A., Gussekloo, J. (Jacobijn), Poortvliet, R.K.E., Ploeg, M.A. (Milly) van der, Streit, S., Achterberg, W.P., Beers, E., Bohnen, A.M. (Arthur), Burman, R.A., Collins, C. (Colin), Franco, F.G., Gerasimovska-Kitanovska, B., Gintere, S., Bravo, R.G., Hoffmann, K., Iftode, C., Pestic, S.K., Koskela, T.H., Kurpas, D., Maisonneuve, H., Mallen, C.D., Merlo, C., Mueller, Y., Muth, C., Petrazzuoli, F., Rodondi, N, Rosemann, T., Sattler, M., Schermer, T., Ster, M.P., Svadlenkova, Z., Tatsioni, A., Thulesius, H., Tkachenko, V. (Valery), Torzsa, P., Tsopra, R., Tuz, C., Vaes, B., Viegas, R.P.A., Vinker, S., Wallis, K.A., Zeller, A., Gussekloo, J. (Jacobijn), and Poortvliet, R.K.E.

Abstract

BACKGROUND: Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners’ (GPs) advice to stop statins in oldestold patients. OBJECTIVE: To investigate the influence of a history of CVD, statin-related side effects, frailty and short life expectancy, on GPs’ advice to stop statins in oldest-old patients. DESIGN: We invited GPs to participate in this case-based survey. GPs were presented with 8 case vignettes describing patients > 80 years using a statin, and asked whether they would advise stopping statin treatment. MAIN MEASURES: Cases varied in history of CVD, statinrelated side effects and frailty, with and without shortened life expectancy (< 1 year) in the context of metastatic, noncurable cancer. Odds ratios adjusted for GP characteristics (ORadj) were calculated for GPs’ advice to stop. KEY RESULTS: Two thousand two hundred fifty GPs from 30 countries participated (median response rate 36%). Overall, GPs advised stopping statin treatment in 46% (95%CI 45–47) of the case vignettes; with shortened life expectancy, this proportion increased to 90% (95CI% 89–90). Advice to stop was more frequent in case vignettes without CVD compared to those with CVD (ORadj 13.8, 95%CI 12.6–15.1), with side effects compared to without ORadj 1.62 (95%CI 1.5–1.7) and with frailty (ORadj 4.1, 95%CI 3.8–4.4) compared to without. Shortened life expectancy increased advice to stop (ORadj 50.7, 95%CI 45.5–56.4) and was the strongest predictor for GP advice to stop, ranging across countries from 30% (95%CI 19– 42) to 98% (95% CI 96–99). CONCLUSIONS: The absence of CVD, the presence of statin-related side effects, and frailty were all independently associated with GPs’ advice to stop statins in patients aged > 80 years. Overall, and within all countries, cancer-related short life expectancy was the strongest independent predictor of GPs’ advice t

Published
2019
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29. Think-aloud study about the diagnosis of chronic heart failure in Belgian general practice

Author

Smeets, M, De Witte, P, Peters, S, Aertgeerts, B, Janssens, S, Vaes, B, Smeets, M, De Witte, P, Peters, S, Aertgeerts, B, Janssens, S, and Vaes, B

Abstract

OBJECTIVES: Diagnosing chronic heart failure (CHF) in general practice is challenging. Our aim was to investigate how general practitioners (GPs) diagnose CHF in real-world patients. DESIGN: Think-aloud study. METHODS: Fourteen GPs were asked to reason about four real-world CHF cases from their own practices. The cases were selected through a clinical audit. This was followed by an interview to get a deeper insight in their reasoning. The Qualitative Analysis Guide of Leuven was used as a guide in data analysis. RESULTS: We developed a conceptual diagnostic model based on three important reasoning steps. First, GPs assessed the likelihood of CHF based on the presence or absence of HF signs and symptoms. However, this approach had serious limitations since GPs experienced many barriers in their clinical assessment, especially in comorbid elderly. Second, if CHF was considered based on step 1, the main influencing factor to take further diagnostic steps was the GPs' perception of the added value of a validated CHF diagnosis in that specific case. Third, the choice and implications of these further diagnostic steps (N-terminal pro B-type natriuretic peptide, ECG and/or cardiac ultrasound) were influenced by the GPs' knowledge about these tests and the quality of the cardiologists' reports. CONCLUSION: This think-aloud study identified the factors that influenced the diagnostic reasoning about CHF in general practice. As a consequence, targets to improve this diagnostic reasoning were withheld: a paradigm shift towards an earlier and more comprehensive risk assessment with, among others, access to natriuretic peptide testing and convincing GPs of the added value of a validated HF diagnosis.

Published
2019

30. Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries

Author

Ploeg, Milly, Streit, S, Achterberg, WP, Beers, E, Bohnen, Arthur, Burman, RA, Collins, C, Franco, FG, Gerasimovska-Kitanovska, B, Gintere, S, Bravo, RG, Hoffmann, K, Iftode, C, Pestic, SK, Koskela, TH, Kurpas, D, Maisonneuve, H, Mallen, CD, Merlo, C, Mueller, Y, Muth, C, Petrazzuoli, F, Rodondi, N, Rosemann, T, Sattler, M, Schermer, T, Ster, MP, Svadlenkova, Z, Tatsioni, A, Thulesius, H, Tkachenko, V, Torzsa, P, Tsopra, R, Tuz, C, Vaes, B, Viegas, RPA, Vinker, S, Wallis, KA, Zeller, A, Gussekloo, J, Poortvliet, RKE, Ploeg, Milly, Streit, S, Achterberg, WP, Beers, E, Bohnen, Arthur, Burman, RA, Collins, C, Franco, FG, Gerasimovska-Kitanovska, B, Gintere, S, Bravo, RG, Hoffmann, K, Iftode, C, Pestic, SK, Koskela, TH, Kurpas, D, Maisonneuve, H, Mallen, CD, Merlo, C, Mueller, Y, Muth, C, Petrazzuoli, F, Rodondi, N, Rosemann, T, Sattler, M, Schermer, T, Ster, MP, Svadlenkova, Z, Tatsioni, A, Thulesius, H, Tkachenko, V, Torzsa, P, Tsopra, R, Tuz, C, Vaes, B, Viegas, RPA, Vinker, S, Wallis, KA, Zeller, A, Gussekloo, J, and Poortvliet, RKE

Published
2019

37. Quantitative Analysis of Paleomagnetic Sampling Strategies

Author

Sapienza, F., Gallo, L. C., Zhang, Y., Vaes, B., Domeier, M., and Swanson‐Hysell, N. L.

Abstract

Sampling strategies used in paleomagnetic studies play a crucial role in dictating the accuracy of our estimates of properties of the ancient geomagnetic field. However, there has been little quantitative analysis of optimal paleomagnetic sampling strategies and the community has instead defaulted to traditional practices that vary between laboratories. In this paper, we quantitatively evaluate the accuracy of alternative paleomagnetic sampling strategies through numerical experiments and an associated analytical framework. Our findings demonstrate a strong correspondence between the accuracy of an estimated paleopole position and the number of sites or independent readings of the time‐varying paleomagnetic field, whereas larger numbers of in‐site samples have a dwindling effect. This remains true even when a large proportion of the sample directions are spurious. This approach can be readily achieved in sedimentary sequences by distributing samples stratigraphically, considering each sample as an individual site. However, where the number of potential independent sites is inherently limited the collection of additional in‐site samples can improve the accuracy of the paleopole estimate (although with diminishing returns with increasing samples per site). Where an estimate of the magnitude of paleosecular variation is sought, multiple in‐site samples should be taken, but the optimal number is dependent on the expected fraction of outliers. The use of filters based on angular distance helps the accuracy of paleopole estimation, but leads to inaccurate estimates of paleosecular variation. We provide both analytical formulas and a series of interactive Jupyter notebooks allowing optimal sampling strategies to be developed from user‐informed expectations. Earth's magnetic field can be preserved in rocks when they form. Through studying these magnetic records using the tools of paleomagnetism, scientists can learn about how Earth's magnetic field has changed through time and how tectonic plates have moved. This study is about the best ways to design sampling approaches to gain these insights using statistical quantification. Traditional protocols emphasize the collection of numerous samples from units that record the field at a given instant in time. Such units are referred to as sites. Through simulating data, we develop tools for evaluating trade‐offs between collecting more sites and more samples per site. Our results show that strategies that maximize collecting more sites, even if fewer samples are taken at each site, leads to more accurate estimates even in the presence of spurious observations. While there is a benefit to more samples per site, particularly for studies seeking to estimate the variability of the ancient field, such sampling has diminishing returns relative to maximizing the number of sites. We provide formulas and interactive computational resources to help the community to make informed decisions about the best way to gather data. We explore the effect of alternative sampling strategies on the accuracy of paleomagnetic parameter estimatesThe accuracy of paleopole estimation is dominated by the number of independent site recordings instead of the number of in‐site samplesEven in the presence of frequent outliers, or for studies of paleosecular variation, a focus on sites over in‐site samples is advantageous We explore the effect of alternative sampling strategies on the accuracy of paleomagnetic parameter estimates The accuracy of paleopole estimation is dominated by the number of independent site recordings instead of the number of in‐site samples Even in the presence of frequent outliers, or for studies of paleosecular variation, a focus on sites over in‐site samples is advantageous

Published
2023
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48. Poster session IV * Friday 10 December 2010, 14:00-18:00

Author

Mora, B., primary, Base, E., additional, Schmid, W., additional, Andreas, M., additional, Weber, U., additional, Junreitmaier, M., additional, Foerster, F., additional, Hiesmayr, M., additional, Tschernich, H. D., additional, Guldbrand, D., additional, Goetzsche, O., additional, Eika, B., additional, Fumagalli, S., additional, Francini, S., additional, Gabbai, D., additional, Pedri, S., additional, Casalone Rinaldi, M., additional, Makhanian, Y., additional, Sollami, R., additional, Tarantini, F., additional, Marchionni, N., additional, Azcarate, P. M., additional, Castano, S., additional, Rodriguez-Manero, M., additional, Arraiza, M., additional, Levy, B., additional, Barba, J., additional, Rabago, G., additional, Bastarrika, G., additional, Rus, H., additional, Radoi, M., additional, Ciurea, C., additional, Boda, D., additional, Erdei, T., additional, Denes, M., additional, Mihalcz, A., additional, Kardos, A., additional, Foldesi, C. S., additional, Temesvari, A., additional, Lengyel, M., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Ballo, P., additional, Henein, M., additional, Mondillo, S., additional, Nistri, S., additional, Galderisi, M., additional, Ballo, P. C., additional, Pagliani, L., additional, Olivotto, I., additional, Santoro, A., additional, Papesso, B., additional, Innelli, P., additional, Cecchi, F., additional, Hristova, K., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Nesheva, N., additional, Ivanovic, B., additional, Tadic, M. T., additional, Simic, D. S., additional, Rao, C. M., additional, Aguglia, D., additional, Casciola, G., additional, Imbesi, C., additional, Marvelli, A., additional, Sgro, M., additional, Benedetto, D., additional, Tripepi, G., additional, Zoccali, C., additional, Benedetto, F. A., additional, Mantziari, L., additional, Kamperidis, V., additional, Damvopoulou, E., additional, Ventoulis, I., additional, Giannakoulas, G., additional, Paraskevaidis, S., additional, Vassilikos, V., additional, Karvounis, H., additional, Styliadis, I. H., additional, Sonder, T. K., additional, Loegstrup, B. B., additional, Lambrechtsen, J., additional, Van Bortel, L. M., additional, Segers, P., additional, Egstrup, K., additional, Tho, A., additional, Moceri, P., additional, Bertora, D., additional, Gibelin, P., additional, Cho, E. J., additional, Choi, K. Y., additional, Kim, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Park, C. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Donal, E., additional, Coquerel, N., additional, Bodi, S., additional, Thebault, C., additional, Kervio, G., additional, Carre, F., additional, Daly, M. J., additional, Fairley, S. L., additional, Doherty, R., additional, Ashfield, K., additional, Kirkpatrick, R., additional, Smith, B., additional, Buchanan, J., additional, Hill, L., additional, Dixon, L. J., additional, Rosca, M., additional, O' Connor, K., additional, Magne, J., additional, Romano, G., additional, Calin, A., additional, Popescu, B. A., additional, Beladan, C. C., additional, Pierard, L., additional, Ginghina, C., additional, Lancellotti, P., additional, Bochenek, T., additional, Wita, K., additional, Tabor, Z., additional, Grabka, M., additional, Elzbieciak, M., additional, Trusz-Gluza, M., additional, Moreau, O., additional, Leclercq, C., additional, Sahlen, A., additional, Shahgaldi, K., additional, Aminoff, A., additional, Aagaard, P., additional, Manouras, A., additional, Winter, R., additional, Ehrenborg, E., additional, Braunschweig, F., additional, Bedetti, G., additional, Gargani, L., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Zhang, J., additional, Zhang, H. B., additional, Duan, Y. Y., additional, Chen, L. L., additional, Li, J., additional, Liu, L. W., additional, Zhu, T., additional, Li, H. L., additional, Su, H. L., additional, Zhou, X. D., additional, Ruiz Ortiz, M., additional, Mesa Rubio, D., additional, Delgado Ortega, M., additional, Romo Penas, E., additional, Toledano Degado, F., additional, Leon Del Pino, C., additional, Lopez Aguilera, J., additional, Villanueva Fernandez, E., additional, Cejudo Diaz Del Campo, L., additional, Suarez De Lezo, J., additional, Abergel, E., additional, Simon, M., additional, Dehant, P., additional, Bogino, E., additional, Jimenez, M., additional, Verdier, J. C., additional, Chauvel, C., additional, Albertsen, A. E., additional, Nielsen, J. C., additional, Mortensen, P. T., additional, Egeblad, H., additional, Nasr, G. M., additional, Tawfik, S., additional, Omar, A., additional, Olofsson, M., additional, Boman, K., additional, Rezzoug, N., additional, Vaes, B., additional, Degryse, J., additional, Vanoverschelde, J.-L., additional, Pasquet, A. A., additional, Poggio, D., additional, Bonadies, M., additional, Pacher, V., additional, Mazzetti, S., additional, Grillo, M., additional, D'elia, E., additional, Khouri, T., additional, Specchia, G., additional, Mornos, C., additional, Rusinaru, D., additional, Cozma, D., additional, Ionac, A., additional, Petrescu, L., additional, Rotzak, R., additional, Rosenman, Y., additional, Patterson, R. D., additional, Ratnatheepan, S., additional, Bogle, R. G., additional, Goebel, B., additional, Gjesdal, O., additional, Kottke, D., additional, Otto, S., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. R., additional, Poerner, T. C., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Itou, N., additional, Ono, T., additional, Yamamoto, M., additional, Osaki, T., additional, Tsuchida, T., additional, Sugi, K., additional, Wolber, T., additional, Haegeli, L., additional, Huerlimann, D., additional, Brunckhorst, C., additional, Duru, F., additional, Wu, Z. M., additional, Shu, X. H., additional, Dong, L. L., additional, Fan, B., additional, Ge, J. B., additional, Greutmann, M., additional, Tobler, D., additional, Biaggi, P., additional, Mah, M., additional, Crean, A., additional, Oechslin, E. N., additional, Silversides, C. K., additional, Giusca, S., additional, Jurcut, R., additional, Ghiorghiu, I., additional, Coman, I. M., additional, Amzulescu, M., additional, Ionescu, R., additional, Delcroix, M., additional, Voigt, J. U., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Maceira Gonzalez, A. M., additional, Cosin-Sales, J., additional, Dalli, E., additional, Igual, B., additional, Monmeneu, J. V., additional, Lopez-Lereu, P., additional, Estornell, J., additional, Ruvira, J., additional, Sotillo, J., additional, Stevanovic, A., additional, Toncev, A., additional, Dimkovic, S., additional, Dekleva, M., additional, Paunovic, N., additional, Toncev, D., additional, Sekularac, N., additional, Yildirimturk, O., additional, Helvacioglu, F. F., additional, Tayyareci, Y., additional, Yurdakul, S., additional, Demiroglu, I. C. C., additional, Aytekin, S., additional, Pinedo Gago, M., additional, Amat Santos, I., additional, Revilla Orodea, A., additional, Lopez Diaz, J., additional, Arnold, R., additional, De La Fuente Galan, L., additional, Recio Platero, A., additional, Gomez Salvador, I., additional, Puerto Sanz, A., additional, San Roman Calvar, J. A., additional, Yotti, R., additional, Bermejo, J., additional, Mombiela, T., additional, Benito, Y., additional, Sanchez, P. L., additional, Solis, J., additional, Prieto, R., additional, Fernandez-Aviles, F., additional, Zilberszac, R., additional, Gabriel, H., additional, Graf, S., additional, Mundigler, G., additional, Maurer, G., additional, Rosenhek, R., additional, Zito, C., additional, Salvia, J., additional, Longordo, C., additional, Donato, D., additional, Alati, E., additional, Miceli, M., additional, Pardeo, A., additional, Arcidiaco, S., additional, Oreto, G., additional, Carerj, S., additional, Hadjimiltiades, S., additional, Sianos, G., additional, Anastasiadis, K., additional, Grosomanidis, V., additional, Efthimiadis, G., additional, Parcharidis, G., additional, Yousry, M., additional, Rickenlund, A., additional, Petrini, J., additional, Gustafsson, T., additional, Liska, J., additional, Hamsten, A., additional, Eriksson, P., additional, Franco-Cereceda, A., additional, Eriksson, M. J., additional, Caidahl, K., additional, Mizia-Stec, K., additional, Pysz, P., additional, Jasinski, M., additional, Drzewiecka-Gerber, A., additional, Krejca, M., additional, Bochenek, A., additional, Wos, S., additional, Gasior, Z., additional, Tendera, M., additional, Niki, K., additional, Sugawara, M., additional, Takamisawa, I., additional, Watanabe, H., additional, Sumiyoshi, T., additional, Hosoda, S., additional, Ida, T., additional, Takanashi, S., additional, Olsen, N. T., additional, Sogaard, P., additional, Jons, C., additional, Mogelvang, R., additional, Larsson, H. B. W., additional, Goetze, J. P., additional, Nielsen, O. W., additional, Fritz-Hansen, T., additional, Sayar, N., additional, Orhan, A. L., additional, Erer, H. B., additional, Eren, M., additional, Atmaca, H., additional, Yilmaz, H. Y., additional, Cakmak, N., additional, Altay, S., additional, Terzi, S., additional, Yesilcimen, K., additional, Garcia Orta, R., additional, Moreno, E., additional, Lopez, M., additional, Uribe, I., additional, Vidal, M., additional, Ruiz-Lopez, M. F., additional, Gonzalez-Molina, M., additional, Oyonarte, J. M., additional, Lopez, S., additional, Azpitarte, J., additional, Szymanski, C., additional, Levine, R. A., additional, Zheng, H., additional, Handschumacher, M. D., additional, Tawakol, A., additional, Hung, J., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Tribouilloy, C., additional, Grigioni, F., additional, Avierinos, J.-F., additional, Barbieri, A., additional, Buiciuc, O., additional, Enriquez-Sarano, M., additional, Said, K., additional, Farag, A. K., additional, El-Ramly, M., additional, Rizk, H., additional, Iorio, A., additional, Pinamonti, B., additional, Bobbo, M., additional, Merlo, M., additional, Massa, L., additional, Faganello, G., additional, Di Lenarda, A., additional, Sinagra, G., additional, Margato, R., additional, Ribeiro, H., additional, Ferreira, C., additional, Matias, A., additional, Fontes, P., additional, Moreira, J. I., additional, Milan, A., additional, Puglisi, E., additional, Magnino, C., additional, Fabbri, A., additional, Leone, D., additional, Vairo, A., additional, Crudo, V., additional, Iannaccone, A., additional, Milazzo, V., additional, Veglio, F., additional, Maroz-Vadalazhskaya, N., additional, Ostrovskiy, I., additional, Imbalzano, E., additional, Saitta, A., additional, Cusma-Piccione, M., additional, Di Bella, G., additional, Nava, R., additional, Ferro, M., additional, Falanga, G., additional, Frigy, A., additional, Buzogany, J., additional, Szabados, C. S., additional, Dan, L., additional, Carasca, E., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tzortzis, S., additional, Kremastinos, D. T., additional, Papadopoulos, C., additional, Paraskevaidis, I., additional, Triantafyllidi, H., additional, Trivilou, P., additional, Venetsanou, K., additional, Anastasiou-Nana, M., additional, Wierzbowska-Drabik, K., additional, Kurpesa, M., additional, Trzos, E., additional, Rechcinski, T., additional, Mozdzan, M., additional, Kasprzak, J. D., additional, Kosmala, W., additional, Kotwica, T., additional, Przewlocka-Kosmala, M., additional, Mysiak, A., additional, Skultetyova, D., additional, Filipova, S., additional, Chnupa, P., additional, Pechlivanidis, G., additional, Dimitroula, H., additional, Tsai, W.-C., additional, Liu, Y.-W., additional, Lin, C.-C., additional, Huang, Y.-Y., additional, Tsai, L.-M., additional, Park, S. M., additional, Kim, Y. H., additional, Shin, S. M., additional, Shim, W. J., additional, Gonzalez Mansilla, A., additional, Torres Macho, J., additional, Sanchez Sanchez, V., additional, Diez, P., additional, Delgado, J., additional, Borruel, S., additional, Saenz De La Calzada, C., additional, Pyxaras, S., additional, Valentincic, M., additional, Barbati, G., additional, Lo Giudice, F., additional, Perkan, A., additional, Magnani, S., additional, Palecek, T., additional, Ambroz, D., additional, Jansa, P., additional, Lindner, J., additional, Vitovec, M., additional, Polacek, P., additional, Jiratova, K., additional, Linhart, A., additional, Baskurt, M., additional, Dogan, G. M., additional, Abaci, O., additional, Kaya, A., additional, Kucukoglu, S., additional, Duszanska, A., additional, Kukulski, T., additional, Skoczylas, I., additional, Majsnerowska, A., additional, Nowowiejska-Wiewiora, A., additional, Streb, W., additional, Szulik, M., additional, Polonski, L., additional, Kalarus, Z., additional, Yerly, P. O., additional, Prella, M., additional, Joly, A., additional, Nicod, L., additional, Aubert, J. D., additional, Aebischer, N., additional, Dores, H., additional, Leal, S., additional, Rosario, I., additional, Correia, M. J., additional, Monge, J., additional, Grilo, A. M., additional, Arroja, I., additional, Fonseca, C., additional, Aleixo, A., additional, Silva, A., additional, Perez-David, E., additional, Sanchez-Alegre, M., additional, Gomez Anta, I., additional, De La Torre, J., additional, Alarcon, J., additional, Garcia Robles, J. A., additional, Lafuente, J., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Gonzalez Guardia, A., additional, Nunez, R., additional, Bosch Carabante, C., additional, Mateu, L., additional, Gual Capllonch, F., additional, Ferrer Sistach, E., additional, Lopez Ayerbe, J., additional, Bayes Genis, A., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Bramos, D., additional, Kalantaridou, A., additional, Takos, D., additional, Skaltsiotis, E., additional, Trika, C., additional, Tsirikos, N., additional, Pamboukas, C., additional, Kottis, G., additional, Toumanidis, S., additional, Aggeli, C., additional, Felekos, I., additional, Roussakis, G., additional, Kazazaki, C., additional, Lampropoulos, K., additional, Lagoudakou, S., additional, Stergiou, C., additional, Pitsavos, C., additional, Stefanadis, C., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Tanaka, T., additional, Uchida, K., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Abrahamsson, A., additional, Gudmundsson, P., additional, Brodin, L., additional, Knebel, F., additional, Schattke, S., additional, Sanad, W., additional, Schimke, I., additional, Schroeckh, S., additional, Brechtel, L., additional, Lock, J., additional, Makauskiene, R., additional, Baumann, G., additional, Borges, A. C., additional, Moelmen-Hansen, H. E., additional, Wisloff, U., additional, Aamot, I. L., additional, Stoylen, A., additional, Ingul, C. B., additional, Estensen, M.-E., additional, Beitnes, J. O., additional, Grindheim, G., additional, Henriksen, T., additional, Aaberge, L., additional, Smiseth, O. A., additional, Gullestad, L., additional, Aakhus, S., additional, Agoston, G., additional, Moggi Pignone, A., additional, Capati, E., additional, Badano, L., additional, Moreo, A., additional, Bombardieri, S., additional, Varga, A., additional, Carrideo, M., additional, Faricelli, S., additional, Corazzini, A., additional, Ippedico, R., additional, Ruggieri, B., additional, Di Blasio, A., additional, D'angelo, E., additional, Di Baldassarre, A., additional, Ripari, P., additional, Gallina, S., additional, Kentrschynskyj, A., additional, Hylander, B., additional, Jacobson, S., additional, Pagels, A., additional, Dumitrescu, S. I., additional, Tintoiu, I., additional, Greere, V., additional, Cristian, G., additional, Chiriac, L., additional, Pinte, F., additional, Droc, I., additional, Neagoe, G., additional, Stanciu, S., additional, Voicu, V. A., additional, Kuch-Wocial, A., additional, Pruszczyk, P., additional, Szmigielski, C. A., additional, Szulc, M., additional, Styczynski, G., additional, Sinski, M., additional, Kaczynska, A., additional, Ryabikov, A., additional, Malyutina, S., additional, Halcox, J., additional, Bobak, M., additional, Nikitin, Y. U., additional, Marmot, M., additional, Barbosa, D., additional, Kiss, G., additional, Orderud, F., additional, Amundsen, B., additional, Jasaityte, R., additional, Loeckx, D., additional, Claus, P., additional, Torp, H., additional, D'hooge, J., additional, Kuhl, J. T., additional, Lonborg, J., additional, Fuchs, A., additional, Andersen, M., additional, Vejlstrup, N., additional, Engstrom, T., additional, Moller, J. E., additional, Kofoed, K. F., additional, Smith, L. A., additional, Bhan, A., additional, Paul, M., additional, Monaghan, M. J., additional, Zaborska, B., additional, Stec, S., additional, Sikora-Frac, M., additional, Krynski, T., additional, Kulakowski, P., additional, Pushparajah, K., additional, Dashwood, D., additional, Barlow, A., additional, Nugent, K., additional, Miller, O., additional, Simpson, J., additional, Valeur, N., additional, Ersboll, M. K., additional, Kjaergaard, J., additional, Greibe, R., additional, Risum, N., additional, Hassager, C., additional, Kober, L., additional, Popovic, D., additional, Nedeljkovic, I., additional, Petrovic, M., additional, Vujisic-Tesic, B., additional, Arandjelovic, A., additional, Stojiljkovic, S., additional, Jakovljevic, B., additional, Damjanovic, S., additional, Ostojic, M., additional, Agrios, I. A., additional, Bramos, D. B., additional, Skaltsiotis, H. S., additional, Takos, D. T., additional, Kaladaridis, A., additional, Vasiladiotis, N. V., additional, Kottis, G. K., additional, Antoniou, A. A., additional, Pamboucas, C. P., additional, Toumanidis, S. T. T., additional, Locorotondo, G., additional, Porto, I., additional, Paraggio, L., additional, Fedele, E., additional, Barchetta, S., additional, De Caterina, A. R., additional, Rebuzzi, A. G., additional, Crea, F., additional, Galiuto, L., additional, Lipiec, P., additional, Szymczyk, E., additional, Michalski, B., additional, Wozniakowski, B., additional, Stefanczyk, L., additional, Rotkiewicz, A., additional, Shim, A., additional, Vainer, J., additional, Habets, J., additional, Lousberg, A., additional, Pont De, C., additional, Waltenberger, J., additional, Farouk, H., additional, Heshmat, H., additional, Adel, A., additional, El Chilali, K., additional, Baghdady, Y., additional, Sorour, K., additional, Gustafsson, U., additional, Larsson, M., additional, Bjallmark, A., additional, Lindqvist, P., additional, A'roch, R., additional, Haney, M., additional, Waldenstrom, A., additional, Mladenovic, Z., additional, Tavciovski, D., additional, Mijailovic, Z., additional, Djordjevic - Dikic, A., additional, Obradovic, S., additional, Matunovic, R., additional, Jovic, Z., additional, Djuric, P., additional, Aase, S., additional, Dalen, H., additional, Sarkola, T., additional, Redington, A. N., additional, Keeley, F., additional, Bradley, T., additional, Jaeggi, E., additional, and Sahlen, H., additional

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2010
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