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1. The energy spectrum of cosmic rays beyond the turn-down around $$\varvec{10^{17}}$$ 10 17 eV as measured with the surface detector of the Pierre Auger Observatory

Author

P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez-Muñiz, R. Alves Batista, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, J. C. Arteaga Velázquez, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, P. Billoir, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, K. S. Caballero-Mora, L. Caccianiga, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, D. Correia dos Santos, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, M. del Río, O. Deligny, A. Di Matteo, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, R. C. dos Anjos, D. dos Santos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, T. Fodran, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, N. Karastathis, B. Keilhauer, J. Kemp, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, N. Kunka, B. L. Lago, R. G. Lang, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, J. Pawlowsky, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, M. Perlin, L. Perrone, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, J. Schulte, A. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, H. Wahlberg, C. Watanabe, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, and Pierre Auger Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We present a measurement of the cosmic-ray spectrum above 100 PeV using the part of the surface detector of the Pierre Auger Observatory that has a spacing of 750 m. An inflection of the spectrum is observed, confirming the presence of the so-called second-knee feature. The spectrum is then combined with that of the 1500 m array to produce a single measurement of the flux, linking this spectral feature with the three additional breaks at the highest energies. The combined spectrum, with an energy scale set calorimetrically via fluorescence telescopes and using a single detector type, results in the most statistically and systematically precise measurement of spectral breaks yet obtained. These measurements are critical for furthering our understanding of the highest energy cosmic rays.

Published
2021
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2. Final results of the LOPES radio interferometer for cosmic-ray air showers

Author

W. D. Apel, J. C. Arteaga-Velázquez, L. Bähren, K. Bekk, M. Bertaina, P. L. Biermann, J. Blümer, H. Bozdog, E. Cantoni, A. Chiavassa, K. Daumiller, V. de Souza, F. Di Pierro, P. Doll, R. Engel, H. Falcke, B. Fuchs, H. Gemmeke, C. Grupen, A. Haungs, D. Heck, J. R. Hörandel, A. Horneffer, D. Huber, T. Huege, P. G. Isar, K.-H. Kampert, D. Kang, O. Krömer, J. Kuijpers, K. Link, P. Łuczak, M. Ludwig, H. J. Mathes, M. Melissas, C. Morello, S. Nehls, J. Oehlschläger, N. Palmieri, T. Pierog, J. Rautenberg, H. Rebel, M. Roth, C. Rühle, A. Saftoiu, H. Schieler, A. Schmidt, S. Schoo, F.G. Schröder, O. Sima, G. Toma, G. C. Trinchero, A. Weindl, J. Wochele, J. Zabierowski, J. A. Zensus, and LOPES Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract LOPES, the LOFAR prototype station, was an antenna array for cosmic-ray air showers operating from 2003 to 2013 within the KASCADE-Grande experiment. Meanwhile, the analysis is finished and the data of air-shower events measured by LOPES are available with open access in the KASCADE Cosmic Ray Data Center (KCDC). This article intends to provide a summary of the achievements, results, and lessons learned from LOPES. By digital, interferometric beamforming the detection of air showers became possible in the radio-loud environment of the Karlsruhe Institute of Technology (KIT). As a prototype experiment, LOPES tested several antenna types, array configurations and calibration techniques, and pioneered analysis methods for the reconstruction of the most important shower parameters, i.e., the arrival direction, the energy, and mass-dependent observables such as the position of the shower maximum. In addition to a review and update of previously published results, we also present new results based on end-to-end simulations including all known instrumental properties. For this, we applied the detector response to radio signals simulated with the CoREAS extension of CORSIKA, and analyzed them in the same way as measured data. Thus, we were able to study the detector performance more accurately than before, including some previously inaccessible features such as the impact of noise on the interferometric cross-correlation beam. These results led to several improvements, which are documented in this paper and can provide useful input for the design of future cosmic-ray experiments based on the digital radio-detection technique.

Published
2021
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3. Direct measurement of the muonic content of extensive air showers between $$\mathbf { 2\times 10^{17}}$$ 2×1017 and $$\mathbf {2\times 10^{18}}~$$ 2×1018 eV at the Pierre Auger Observatory

Author

A. Aab, P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, T. Bister, J. Biteau, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K. S. Caballero-Mora, L. Caccianiga, L. Calcagni, A. Cancio, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, K. Choi, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, V. de Souza, J. Debatin, M. del Río, O. Deligny, N. Dhital, A. Di Matteo, M. L. Díaz Castro, C. Dobrigkeit, J. C. D’Olivo, Q. Dorosti, R. C. dos Anjos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, J. Glombitza, F. Gobbi, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, R. Halliday, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P. G. Isar, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, J. Kemp, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, G. Kukec Mezek, B. L. Lago, D. LaHurd, R. G. Lang, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, A. López Casado, R. Lorek, Q. Luce, A. Lucero, A. Machado Payeras, M. Malacari, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, S. Müller, R. Mussa, M. Muzio, W. M. Namasaka, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A Nucita, L. A. Núñez, M. Palatka, J. Pallotta, M. P. Panetta, P. Papenbreer, G. Parente, A. Parra, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, J. Perez Armand, M. Perlin, L. Perrone, C. Peters, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, S. J. Sciutto, M. Scornavacche, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, J. Šupík, Z. Szadkowski, A. Taboada, O. A. Taborda, A. Tapia, C. Timmermans, P. Tobiska, C. J. Todero Peixoto, B. Tomé, G. Torralba Elipe, A. Travaini, P. Travnicek, C. Trimarelli, M. Trini, M. Tueros, R. Ulrich, M. Unger, M. Urban, L. Vaclavek, J. F. Valdés Galicia, I. Valiño, L. Valore, A. van Vliet, E. Varela, B. Vargas Cárdenas, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, L. Villaseñor, J. Vink, S. Vorobiov, H. Wahlberg, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, T. Winchen, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, A. Zepeda, M. Ziolkowski, F. Zuccarello, and The Pierre Auger Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The hybrid design of the Pierre Auger Observatory allows for the measurement of the properties of extensive air showers initiated by ultra-high energy cosmic rays with unprecedented precision. By using an array of prototype underground muon detectors, we have performed the first direct measurement, by the Auger Collaboration, of the muon content of air showers between $$2\times 10^{17}$$ 2×1017 and $$2\times 10^{18}$$ 2×1018 eV. We have studied the energy evolution of the attenuation-corrected muon density, and compared it to predictions from air shower simulations. The observed densities are found to be larger than those predicted by models. We quantify this discrepancy by combining the measurements from the muon detector with those from the Auger fluorescence detector at $$10^{{17.5}}\, {\mathrm{eV}} $$ 1017.5eV and $$10^{{18}}\, {\mathrm{eV}} $$ 1018eV . We find that, for the models to explain the data, an increase in the muon density of $$38\%$$ 38% $$\pm 4\% (12\%)$$ ±4%(12%) $$\pm {}^{21\%}_{18\%}$$ ±18%21% for EPOS-LHC, and of $$50\% (53\%)$$ 50%(53%) $$\pm 4\% (13\%)$$ ±4%(13%) $$\pm {}^{23\%}_{20\%}$$ ±20%23% for QGSJetII-04, is respectively needed.

Published
2020
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4. Search for Ultra-high-energy Photons from Gravitational Wave Sources with the Pierre Auger Observatory

Author

A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, J. Alvarez-Muñiz, J. Ammerman Yebra, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, E. Arnone, J. C. Arteaga Velázquez, H. Asorey, P. Assis, G. Avila, E. Avocone, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, J. A. Bellido, C. Berat, M. E. Bertaina, G. Bhatta, P. L. Biermann, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, J. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, A. Bwembya, K. S. Caballero-Mora, L. Caccianiga, I. Caracas, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceiçao, A. Condorelli, G. Consolati, M. Conte, F. Contreras, F. Convenga, D. Correia dos Santos, P. J. Costa, C. E. Covault, M. Cristinziani, C. S. Cruz Sanchez, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, J. de Jesús, S. J. de Jong, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, A. Del Popolo, O. Deligny, L. Deval, A. di Matteo, M. Dobre, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, R. C. dos Anjos, J. Ebr, M. Emam, R. Engel, I. Epicoco, M. Erdmann, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, A. Fernandes, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, B. Flaggs, T. Fodran, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, F. Knapp, N. Kunka, B. L. Lago, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, M. Majercakova, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, F. M. Mariani, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, O. Martínez Bravo, M. A. Martins, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, S. Mayotte, P. O. Mazur, G. Medina-Tanco, J. Meinert, D. Melo, A. Menshikov, S. Michal, M. I. Micheletti, L. Miramonti, S. Mollerach, F. Montanet, L. Morejon, C. Morello, A. L. Müller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, G. Nicora, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, I. Norwood, D. Nosek, V. Novotny, L. Nožka, A. Nucita, L. A. Núñez, C. Oliveira, M. Palatka, J. Pallotta, G. Parente, A. Parra, J. Pawlowsky, M. Pech, J. Pȩkala, R. Pelayo, L. A. S. Pereira, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, L. Perrone, S. Petrera, C. Petrucci, T. Pierog, M. Pimenta, M. Platino, B. Pont, M. Pothast, M. Pourmohammad Shavar, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, S. Rossoni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, A. Saftoiu, M. Saharan, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, H. Schoorlemmer, P. Schovánek, F. G. Schröder, J. Schulte, T. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, S. U. Shivashankara, G. Sigl, G. Silli, O. Sima, R. Smau, R. Šmída, P. Sommers, J. F. Soriano, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Straub, A. Streich, M. Suárez-Durán, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, C. Watanabe, A. A. Watson, A. Weindl, L. Wiencke, H. Wilczyński, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, and The Pierre Auger Collaboration

Subjects
Particle astrophysics, Ultra-high-energy cosmic radiation, Cosmic ray showers, Gravitational wave sources, Transient sources, Astrophysics, QB460-466
Abstract

A search for time-directional coincidences of ultra-high-energy (UHE) photons above 10 EeV with gravitational wave (GW) events from the LIGO/Virgo runs O1 to O3 is conducted with the Pierre Auger Observatory. Due to the distinctive properties of photon interactions and to the background expected from hadronic showers, a subset of the most interesting GW events is selected based on their localization quality and distance. Time periods of 1000 s around and 1 day after the GW events are analyzed. No coincidences are observed. Upper limits on the UHE photon fluence from a GW event are derived that are typically at ∼7 MeV cm ^−2 (time period 1000 s) and ∼35 MeV cm ^−2 (time period 1 day). Due to the proximity of the binary neutron star merger GW170817, the energy of the source transferred into UHE photons above 40 EeV is constrained to be less than 20% of its total GW energy. These are the first limits on UHE photons from GW sources.

Published
2023
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5. A Catalog of the Highest-energy Cosmic Rays Recorded during Phase I of Operation of the Pierre Auger Observatory

Author

A. Abdul Halim, P. Abreu, M. Aglietta, I. Allekotte, P. Allison, K. Almeida Cheminant, A. Almela, J. Alvarez-Muñiz, J. Ammerman Yebra, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, E. Arnone, J. C. Arteaga Velázquez, H. Asorey, P. Assis, M. Ave, G. Avila, E. Avocone, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, J. Beatty, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, G. Bhatta, P. L. Biermann, P. Billoir, V. Binet, K. Bismark, T. Bister, J. Biteau, J. Blazek, C. Bleve, J. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, J. Brack, T. Bretz, P. G. Brichetto Orchera, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, M. Büsken, A. Bwembya, K. S. Caballero-Mora, L. Caccianiga, I. Caracas, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, R. Cester, J. A. Chinellato, J. Chirinos, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, D. Correia dos Santos, C. E. Covault, M. Cristinziani, C. S. Cruz Sanchez, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, J. de Jesús, S. J. de Jong, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, F. de Palma, V. de Souza, E. De Vito, A. Del Popolo, O. Deligny, L. Deval, A. di Matteo, M. Dobre, C. Dobrigkeit, J. C. D’Olivo, L. M. Domingues Mendes, A. Dorofeev, R. C. dos Anjos, J. Ebr, M. Eman, R. Engel, I. Epicoco, M. Erdmann, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fitoussi, B. Flaggs, T. Fodran, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, J. M. González, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, P. Hamal, M. R. Hampel, P. Hansen, D. Harari, J. Harton, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, A. Insolia, P. G. Isar, P. Janecek, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, A. Khakurdikar, V. V. Kizakke Covilakam, H. O. Klages, M. Kleifges, J. Kleinfeller, F. Knapp, J. Knapp, N. Kunka, C. Lachaud, B. L. Lago, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, L. Lu, Q. Luce, J. P. Lundquist, A. Machado Payeras, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, F. M. Mariani, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, S. Martinelli, O. Martínez Bravo, M. A. Martins, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, S. Mayotte, P. O. Mazur, G. Medina-Tanco, J. Meinert, D. Melo, A. Menshikov, S. Michal, M. I. Micheletti, L. Miramonti, S. Mollerach, F. Montanet, L. Morejon, C. Morello, A. L. Müller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, A. Nasr-Esfahani, L. Nellen, G. Nicora, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, I. Norwood, D. Nosek, V. Novotny, L. Nožka, A Nucita, L. A. Núñez, C. Oliveira, M. Palatka, J. Pallotta, G. Parente, A. Parra, J. Pawlowsky, M. Pech, J. Pȩkala, R. Pelayo, E. E. Pereira Martins, J. Perez Armand, C. Pérez Bertolli, L. Perrone, S. Petrera, C. Petrucci, T. Pierog, M. Pimenta, M. Platino, B. Pont, M. Pothast, M. Pourmohammad Shavar, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, S. Rossoni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, A. Saftoiu, M. Saharan, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, H. Schoorlemmer, P. Schovánek, F. G. Schröder, J. Schulte, T. Schulz, S. J. Sciutto, M. Scornavacche, A. Segreto, S. Sehgal, S. U. Shivashankara, G. Sigl, G. Silli, O. Sima, R. Smau, R. Šmída, P. Sommers, J. F. Soriano, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Straub, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, Z. Szadkowski, A. Tapia, C. Taricco, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, Z. Torrès, A. Travaini, P. Travnicek, C. Trimarelli, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, L. M. Villase nor Cendejas, J. Vink, S. Vorobiov, C. Watanabe, A. A. Watson, A. Weindl, L. Wiencke, H. Wilczyński, D. Wittkowski, B. Wundheiler, P. Younk, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, and (The Pierre Auger Collaboration)

Subjects
Ultra-high-energy cosmic radiation, Cosmic ray showers, Experimental data, Catalogs, Astrophysics, QB460-466
Abstract

A catalog containing details of the highest-energy cosmic rays recorded through the detection of extensive air showers at the Pierre Auger Observatory is presented with the aim of opening the data to detailed examination. Descriptions of the 100 showers created by the highest-energy particles recorded between 2004 January 1 and 2020 December 31 are given for cosmic rays that have energies in the range 78–166 EeV. Details are also given on a further nine very energetic events that have been used in the calibration procedure adopted to determine the energy of each primary. A sky plot of the arrival directions of the most energetic particles is shown. No interpretations of the data are offered.

Published
2023
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6. The KASCADE Cosmic-ray Data Centre KCDC: granting open access to astroparticle physics research data

Author

A. Haungs, D. Kang, S. Schoo, D. Wochele, J. Wochele, W. D. Apel, J. C. Arteaga-Velázquez, K. Bekk, M. Bertaina, J. Blümer, H. Bozdog, I. M. Brancus, E. Cantoni, A. Chiavassa, F. Cossavella, K. Daumiller, V. de Souza, F. Di Pierro, P. Doll, R. Engel, B. Fuchs, D. Fuhrmann, A. Gherghel-Lascu, H. J. Gils, R. Glasstetter, C. Grupen, D. Heck, J. R. Hörandel, T. Huege, K. H. Kampert, H. O. Klages, K. Link, P. Łuczak, H. J. Mathes, H. J. Mayer, J. Milke, B. Mitrica, C. Morello, J. Oehlschläger, S. Ostapchenko, M. Petcu, T. Pierog, H. Rebel, M. Roth, H. Schieler, F. G. Schröder, O. Sima, G. Toma, G. C. Trinchero, H. Ulrich, A. Weindl, and J. Zabierowski

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The ‘KASCADE Cosmic ray Data Centre’ is a web portal (https://kcdc.ikp.kit.edu), where the data of the astroparticle physics experiment KASCADE-Grande are made available for the interested public. The KASCADE experiment was a large-area detector for the measurement of high-energy cosmic rays via the detection of extensive air showers. The multi-detector installations KASCADE and its extension KASCADE-Grande stopped the active data acquisition in 2013 after more than 20 years of data taking. In several updates since our first release in 2013 with KCDC we provide the public measured and reconstructed parameters of more than 433 million air showers. In addition, KCDC provides meta data information and documentation to enable a user outside the community of experts to perform their own data analysis. Simulation data from three different high energy interaction models have been made available as well as a compilation of measured and published spectra from various experiments. In addition, detailed educational examples shall encourage high-school students and early stage researchers to learn about astroparticle physics, cosmic radiation as well as the handling of Big Data and about the sustainable and public provision of scientific data.

Published
2018
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7. MARTA: a high-energy cosmic-ray detector concept for high-accuracy muon measurement

Author

P. Abreu, S. Andringa, P. Assis, A. Blanco, V. Barbosa Martins, P. Brogueira, N. Carolino, L. Cazon, M. Cerda, G. Cernicchiaro, R. Colalillo, R. Conceição, O. Cunha, R. M. de Almeida, V. de Souza, F. Diogo, C. Dobrigkeit, J. Espadanal, C. Espirito-Santo, M. Ferreira, P. Ferreira, P. Fonte, U. Giaccari, P. Gonçalves, F. Guarino, O. C. Lippmann, L. Lopes, R. Luz, D. Maurizio, F. Marujo, P. Mazur, L. Mendes, A. Pereira, Mario Pimenta, R. R. Prado, J. R̆ídký, R. Sarmento, C. Scarso, R. Shellard, J. Souza, B. Tomé, P. Trávníc̆ek, J. Vícha, H. Wolters, and E. Zas

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A new concept for the direct measurement of muons in air showers is presented. The concept is based on resistive plate chambers (RPCs), which can directly measure muons with very good space and time resolution. The muon detector is shielded by placing it under another detector able to absorb and measure the electromagnetic component of the showers such as a water-Cherenkov detector, commonly used in air shower arrays. The combination of the two detectors in a single, compact detector unit provides a unique measurement that opens rich possibilities in the study of air showers.

Published
2018
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8. A comparison of the cosmic-ray energy scales of Tunka-133 and KASCADE-Grande via their radio extensions Tunka-Rex and LOPES

Author

W.D. Apel, J.C. Arteaga-Velázquez, L. Bähren, P.A. Bezyazeekov, K. Bekk, M. Bertaina, P.L. Biermann, J. Blümer, H. Bozdog, I.M. Brancus, N.M. Budnev, E. Cantoni, A. Chiavassa, K. Daumiller, V. de Souza, F. Di Pierro, P. Doll, R. Engel, H. Falcke, O. Fedorov, B. Fuchs, H. Gemmeke, O.A. Gress, C. Grupen, A. Haungs, D. Heck, R. Hiller, J.R. Hörandel, A. Horneffer, D. Huber, T. Huege, P.G. Isar, K.-H. Kampert, D. Kang, Y. Kazarina, M. Kleifges, E.E. Korosteleva, D. Kostunin, O. Krömer, J. Kuijpers, L.A. Kuzmichev, K. Link, N. Lubsandorzhiev, P. Łuczak, M. Ludwig, H.J. Mathes, M. Melissas, R.R. Mirgazov, R. Monkhoev, C. Morello, J. Oehlschläger, E.A. Osipova, A. Pakhorukov, N. Palmieri, L. Pankov, T. Pierog, V.V. Prosin, J. Rautenberg, H. Rebel, M. Roth, G.I. Rubtsov, C. Rühle, A. Saftoiu, H. Schieler, A. Schmidt, S. Schoo, F.G. Schröder, O. Sima, G. Toma, G.C. Trinchero, A. Weindl, R. Wischnewski, J. Wochele, J. Zabierowski, A. Zagorodnikov, and J.A. Zensus

Subjects
Physics, QC1-999
Abstract

The radio technique is a promising method for detection of cosmic-ray air showers of energies around 100PeV and higher with an array of radio antennas. Since the amplitude of the radio signal can be measured absolutely and increases with the shower energy, radio measurements can be used to determine the air-shower energy on an absolute scale. We show that calibrated measurements of radio detectors operated in coincidence with host experiments measuring air showers based on other techniques can be used for comparing the energy scales of these host experiments. Using two approaches, first via direct amplitude measurements, and second via comparison of measurements with air shower simulations, we compare the energy scales of the air-shower experiments Tunka-133 and KASCADE-Grande, using their radio extensions, Tunka-Rex and LOPES, respectively. Due to the consistent amplitude calibration for Tunka-Rex and LOPES achieved by using the same reference source, this comparison reaches an accuracy of approximately 10% – limited by some shortcomings of LOPES, which was a prototype experiment for the digital radio technique for air showers. In particular we show that the energy scales of cosmic-ray measurements by the independently calibrated experiments KASCADE-Grande and Tunka-133 are consistent with each other on this level. Keywords: Cosmic rays, Radio detection, LOPES, Tunka-Rex, Tunka-133, KASCADE-Grande

Published
2016
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9. Multi-Messenger Physics With the Pierre Auger Observatory

Author

Karl-Heinz Kampert, Miguel Alejandro Mostafa, Enrique Zas, The Pierre Auger Collaboration, A. Aab, P. Abreu, M. Aglietta, I.F.M. Albuquerque, J.M. Albury, I. Allekotte, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, G.A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, H. Asorey, P. Assis, G. Avila, A.M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R.J. Barreira Luz, S. Baur, K.H. Becker, J.A. Bellido, C. Berat, M.E. Bertaina, X. Bertou, P.L. Biermann, J. Biteau, S.G. Blaess, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, N. Borodai, A.M. Botti, J. Brack, T. Bretz, A. Bridgeman, F.L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K.S. Caballero-Mora, L. Caccianiga, L. Calcagni, A. Cancio, F. Canfora, J.M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J.A. Chinellato, J. Chudoba, L. Chytka, R.W. Clay, A.C. Cobos Cerutti, R. Colalillo, A. Coleman, M.R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, M.J. Cooper, S. Coutu, C.E. Covault, B. Daniel, S. Dasso, K. Daumiller, B.R. Dawson, J.A. Day, R.M. de Almeida, S.J. de Jong, G. De Mauro, J.R.T. de Mello Neto, I. De Mitri, J. de Oliveira, F.O. de Oliveira Salles, V. de Souza, J. Debatin, M. del Río, O. Deligny, N. Dhital, M.L. Díaz Castro, F. Diogo, C. Dobrigkeit, J.C. D'Olivo, Q. Dorosti, R.C. dos Anjos, M.T. Dova, A. Dundovic, J. Ebr, R. Engel, M. Erdmann, C.O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A.C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, L.P. Ferreyro, J.M. Figueira, A. Filipčič, M.M. Freire, T. Fujii, A. Fuster, B. García, H. Gemmeke, A. Gherghel-Lascu, P.L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, D. Głas, J. Glombitza, F. Gobbi, G. Golup, M. Gómez Berisso, P.F. Gómez Vitale, J.P. Gongora, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T.D. Grubb, F. Guarino, G.P. Guedes, E. Guido, R. Halliday, M.R. Hampel, P. Hansen, D. Harari, T.A. Harrison, V.M. Harvey, A. Haungs, T. Hebbeker, D. Heck, P. Heimann, G.C. Hill, C. Hojvat, E.M. Holt, P. Homola, J.R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P.G. Isar, I. Jandt, J.A. Johnsen, M. Josebachuili, J. Jurysek, A. Kääpä, K.H. Kampert, B. Keilhauer, N. Kemmerich, J. Kemp, H.O. Klages, M. Kleifges, J. Kleinfeller, R. Krause, D. Kuempel, G. Kukec Mezek, A. Kuotb Awad, B.L. Lago, D. LaHurd, R.G. Lang, R. Legumina, M.A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, O.C. Lippmann, D. Lo Presti, L. Lopes, R. López, A. López Casado, R. Lorek, Q. Luce, A. Lucero, M. Malacari, G. Mancarella, D. Mandat, B.C. Manning, P. Mantsch, A.G. Mariazzi, I.C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H.J. Mathes, S. Mathys, J. Matthews, G. Matthiae, E. Mayotte, P.O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M.I. Micheletti, L. Middendorf, L. Miramonti, B. Mitrica, D. Mockler, S. Mollerach, F. Montanet, C. Morello, G. Morlino, M. Mostafá, A.L. Müller, M.A. Muller, S. Müller, R. Mussa, L. Nellen, P.H. Nguyen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A Nucita, L.A. Núñez, F. Oikonomou, A. Olinto, M. Palatka, J. Pallotta, M.P. Panetta, P. Papenbreer, G. Parente, A. Parra, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, L.A.S. Pereira, M. Perlin, L. Perrone, C. Peters, S. Petrera, J. Phuntsok, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, J. Poh, B. Pont, C. Porowski, R.R. Prado, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, S. Quinn, R. Ramos-Pollan, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M.J. Roncoroni, M. Roth, E. Roulet, A.C. Rovero, P. Ruehl, S.J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J.D. Sanabria Gomez, F. Sánchez, E.M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, M. Schauer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F.G. Schröder, S. Schröder, J. Schumacher, S.J. Sciutto, M. Scornavacche, R.C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, G.R. Snow, P. Sommers, J.F. Soriano, J. Souchard, R. Squartini, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, M. Stolpovskiy, A. Streich, F. Suarez, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A.D. Supanitsky, J. Šupík, Z. Szadkowski, A. Taboada, O.A. Taborda, A. Tapia, C. Timmermans, C.J. Todero Peixoto, B. Tomé, G. Torralba Elipe, A. Travaini, P. Travnicek, M. Trini, M. Tueros, R. Ulrich, M. Unger, M. Urban, J.F. Valdés Galicia, I. Valiño, L. Valore, P. van Bodegom, A.M. van den Berg, A. van Vliet, E. Varela, B. Vargas Cárdenas, D. Veberič, C. Ventura, I.D. Vergara Quispe, V. Verzi, J. Vicha, L. Villaseñor, J. Vink, S. Vorobiov, H. Wahlberg, A.A. Watson, M. Weber, A. Weindl, M. Wiedeński, L. Wiencke, H. Wilczyński, T. Winchen, M. Wirtz, D. Wittkowski, B. Wundheiler, L. Yang, A. Yushkov, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, A. Zepeda, B. Zimmermann, M. Ziolkowski, Z. Zong, and F. Zuccarello

Subjects
UHECR, high energy neutrinos, high energy photons, high energy neutrons, multi-messenger astrophysics, compact binary mergers, Astronomy, QB1-991, Geophysics. Cosmic physics, QC801-809
Abstract

An overview of the multi-messenger capabilities of the Pierre Auger Observatory is presented. The techniques and performance of searching for Ultra-High Energy neutrinos, photons and neutrons are described. Some of the most relevant results are reviewed, such as stringent upper bounds that were placed to a flux of diffuse cosmogenic neutrinos and photons, bounds placed on neutrinos emitted from compact binary mergers that were detected by LIGO and Virgo during their first and second observing runs, as well as searches for high energy photons and neutrons from the Galactic center that constrain the properties of the putative Galactic PeVatron, observed by the H.E.S.S. collaboration. The observation of directional correlations between ultra-high energy cosmic rays and either high energy astrophysical neutrinos or specific source populations, weighted by their electromagnetic radiation, are also discussed. They constitute additional multi-messenger approaches aimed at identifying the sources of high energy cosmic rays.

Published
2019
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10. Physics informed neural networks learning a two-qubit Hamiltonian

Author

Castelano, Leonardo K., Cunha, Iann, Luiz, Fabricio S., Prado, Marcelo V. de Souza, and Fanchini, Felipe F.

Subjects
Quantum Physics
Abstract

Machine learning techniques are employed to perform the full characterization of a quantum system. The particular artificial intelligence technique used to learn the Hamiltonian is called physics informed neural network (PINN). The idea behind PINN is the universal approximation theorem, which claims that any function can be approximate by a neural network if it contains enough complexity. Consequently, a neural network can be a solution of a physical model. Moreover, by means of extra data provided by the user, intrinsic physical parameters can be extracted from the approach called inverse-PINN. Here, we apply inverse-PINN with the goal of extracting all the physical parameters that constitutes a two qubit Hamiltonian. We find that this approach is very efficient. To probe the robustness of the inverse-PINN to learn the Hamiltonian of a two-qubit system, we use the IBM quantum computers as experimental platforms to obtain the data that is plugged in the PINN. We found that our method is able to predict the two-qubit parameters with 5% of accuracy on average., Comment: 5 pages, 4 figures

Published
2023

11. HCN emission from translucent gas and UV-illuminated cloud edges revealed by wide-field IRAM 30m maps of Orion B GMC: Revisiting its role as tracer of the dense gas reservoir for star formation

Author

Santa-Maria, M. G., Goicoechea, J. R., Pety, J., Gerin, M., Orkisz, J. H., Petit, F. Le, Einig, L., Palud, P., Magalhaes, V. de Souza, Bešlić, I., Segal, L., Bardeau, S., Bron, E., Chainais, P., Chanussot, J., Gratier, P., Guzmán, V. V., Hughes, A., Languignon, D., Levrier, F., Lis, D. C., Liszt, H. S., Bourlot, J. Le, Oya, Y., Öberg, K., Peretto, N., Roueff, E., Roueff, A., Sievers, A., Thouvenin, P. -A., and Yamamoto, S.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present 5 deg^2 (~250 pc^2) HCN, HNC, HCO+, and CO J=1-0 maps of the Orion B GMC, complemented with existing wide-field [CI] 492 GHz maps, as well as new pointed observations of rotationally excited HCN, HNC, H13CN, and HN13C lines. We detect anomalous HCN J=1-0 hyperfine structure line emission almost everywhere in the cloud. About 70% of the total HCN J=1-0 luminosity arises from gas at A_V < 8 mag. The HCN/CO J=1-0 line intensity ratio shows a bimodal behavior with an inflection point at A_V < 3 mag typical of translucent gas and UV-illuminated cloud edges. We find that most of the HCN J=1-0 emission arises from extended gas with n(H2) ~< 10^4 cm^-3, even lower density gas if the ionization fraction is > 10^-5 and electron excitation dominates. This result explains the low-A_V branch of the HCN/CO J=1-0 intensity ratio distribution. Indeed, the highest HCN/CO ratios (~0.1) at A_V < 3 mag correspond to regions of high [CI] 492 GHz/CO J=1-0 intensity ratios (>1) characteristic of low-density PDRs. Enhanced FUV radiation favors the formation and excitation of HCN on large scales, not only in dense star-forming clumps. The low surface brightness HCN and HCO+ J=1-0 emission scale with I_FIR (a proxy of the stellar FUV radiation field) in a similar way. Together with CO J=1-0, these lines respond to increasing I_FIR up to G0~20. On the other hand, the bright HCN J=1-0 emission from dense gas in star-forming clumps weakly responds to I_FIR once the FUV radiation field becomes too intense (G0>1500). The different power law scalings (produced by different chemistries, densities, and line excitation regimes) in a single but spatially resolved GMC resemble the variety of Kennicutt-Schmidt law indexes found in galaxy averages. As a corollary for extragalactic studies, we conclude that high HCN/CO J=1-0 line intensity ratios do not always imply the presence of dense gas., Comment: accepted for publication in A&A. 24 pages, 18 figures, plus Appendix. Abridged Abstract

Published
2023
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12. Evidence for a mixed mass composition at the ‘ankle’ in the cosmic-ray spectrum

Author

A. Aab, P. Abreu, M. Aglietta, E.J. Ahn, I. Al Samarai, I.F.M. Albuquerque, I. Allekotte, P. Allison, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, M. Ambrosio, G.A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, F. Arqueros, N. Arsene, H. Asorey, P. Assis, J. Aublin, G. Avila, A.M. Badescu, A. Balaceanu, C. Baus, J.J. Beatty, K.H. Becker, J.A. Bellido, C. Berat, M.E. Bertaina, P.L. Biermann, P. Billoir, J. Biteau, S.G. Blaess, A. Blanco, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, N. Borodai, A.M. Botti, J. Brack, I. Brancus, T. Bretz, A. Bridgeman, F.L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K.S. Caballero-Mora, B. Caccianiga, L. Caccianiga, A. Cancio, F. Canfora, L. Caramete, R. Caruso, A. Castellina, G. Cataldi, L. Cazon, R. Cester, A.G. Chavez, A. Chiavassa, J.A. Chinellato, J. Chudoba, R.W. Clay, R. Colalillo, A. Coleman, L. Collica, M.R. Coluccia, R. Conceição, F. Contreras, M.J. Cooper, S. Coutu, C.E. Covault, J. Cronin, R. Dallier, S. D'Amico, B. Daniel, S. Dasso, K. Daumiller, B.R. Dawson, R.M. de Almeida, S.J. de Jong, G. De Mauro, J.R.T. de Mello Neto, I. De Mitri, J. de Oliveira, V. de Souza, J. Debatin, L. del Peral, O. Deligny, C. Di Giulio, A. Di Matteo, M.L. Díaz Castro, F. Diogo, C. Dobrigkeit, J.C. D'Olivo, A. Dorofeev, R.C. dos Anjos, M.T. Dova, A. Dundovic, J. Ebr, R. Engel, M. Erdmann, M. Erfani, C.O. Escobar, J. Espadanal, A. Etchegoyen, H. Falcke, K. Fang, G. Farrar, A.C. Fauth, N. Fazzini, B. Fick, J.M. Figueira, A. Filevich, A. Filipčič, O. Fratu, M.M. Freire, T. Fujii, A. Fuster, B. García, D. Garcia-Pinto, F. Gaté, H. Gemmeke, A. Gherghel-Lascu, P.L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, D. Głas, C. Glaser, H. Glass, G. Golup, M. Gómez Berisso, P.F. Gómez Vitale, N. González, B. Gookin, J. Gordon, A. Gorgi, P. Gorham, P. Gouffon, A.F. Grillo, T.D. Grubb, F. Guarino, G.P. Guedes, M.R. Hampel, P. Hansen, D. Harari, T.A. Harrison, J.L. Harton, Q. Hasankiadeh, A. Haungs, T. Hebbeker, D. Heck, P. Heimann, A.E. Herve, G.C. Hill, C. Hojvat, E. Holt, P. Homola, J.R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P.G. Isar, I. Jandt, S. Jansen, J.A. Johnsen, M. Josebachuili, A. Kääpä, O. Kambeitz, K.H. Kampert, P. Kasper, I. Katkov, B. Keilhauer, E. Kemp, R.M. Kieckhafer, H.O. Klages, M. Kleifges, J. Kleinfeller, R. Krause, N. Krohm, D. Kuempel, G. Kukec Mezek, N. Kunka, A. Kuotb Awad, D. LaHurd, L. Latronico, M. Lauscher, P. Lautridou, P. Lebrun, R. Legumina, M.A. Leigui de Oliveira, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, L. Lopes, R. López, A. López Casado, Q. Luce, A. Lucero, M. Malacari, M. Mallamaci, D. Mandat, P. Mantsch, A.G. Mariazzi, I.C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, J.J. Masías Meza, H.J. Mathes, S. Mathys, J. Matthews, J.A.J. Matthews, G. Matthiae, E. Mayotte, P.O. Mazur, C. Medina, G. Medina-Tanco, D. Melo, A. Menshikov, S. Messina, M.I. Micheletti, L. Middendorf, I.A. Minaya, L. Miramonti, B. Mitrica, D. Mockler, L. Molina-Bueno, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, G. Müller, M.A. Muller, S. Müller, I. Naranjo, S. Navas, L. Nellen, J. Neuser, P.H. Nguyen, M. Niculescu-Oglinzanu, M. Niechciol, L. Niemietz, T. Niggemann, D. Nitz, D. Nosek, V. Novotny, H. Nožka, L.A. Núñez, L. Ochilo, F. Oikonomou, A. Olinto, D. Pakk Selmi-Dei, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, T. Paul, M. Pech, F. Pedreira, J. Pȩkala, R. Pelayo, J. Peña-Rodriguez, L.A.S. Pereira, L. Perrone, C. Peters, S. Petrera, J. Phuntsok, R. Piegaia, T. Pierog, P. Pieroni, M. Pimenta, V. Pirronello, M. Platino, M. Plum, C. Porowski, R.R. Prado, P. Privitera, M. Prouza, E.J. Quel, S. Querchfeld, S. Quinn, R. Ramos-Pollant, J. Rautenberg, O. Ravel, D. Ravignani, D. Reinert, B. Revenu, J. Ridky, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, G. Rodriguez Fernandez, J. Rodriguez Rojo, M.D. Rodríguez-Frías, D. Rogozin, J. Rosado, M. Roth, E. Roulet, A.C. Rovero, S.J. Saffi, A. Saftoiu, H. Salazar, A. Saleh, F. Salesa Greus, G. Salina, J.D. Sanabria Gomez, F. Sánchez, P. Sanchez-Lucas, E.M. Santos, E. Santos, F. Sarazin, B. Sarkar, R. Sarmento, C. Sarmiento-Cano, R. Sato, C. Scarso, M. Schauer, V. Scherini, H. Schieler, D. Schmidt, O. Scholten, P. Schovánek, F.G. Schröder, A. Schulz, J. Schulz, J. Schumacher, S.J. Sciutto, A. Segreto, M. Settimo, A. Shadkam, R.C. Shellard, G. Sigl, G. Silli, O. Sima, A. Śmiałkowski, R. Šmída, G.R. Snow, P. Sommers, S. Sonntag, J. Sorokin, R. Squartini, D. Stanca, S. Stanič, J. Stasielak, F. Strafella, F. Suarez, M. Suarez Durán, T. Sudholz, T. Suomijärvi, A.D. Supanitsky, M.S. Sutherland, J. Swain, Z. Szadkowski, O.A. Taborda, A. Tapia, A. Tepe, V.M. Theodoro, C. Timmermans, C.J. Todero Peixoto, L. Tomankova, B. Tomé, A. Tonachini, G. Torralba Elipe, D. Torres Machado, M. Torri, P. Travnicek, M. Trini, R. Ulrich, M. Unger, M. Urban, A. Valbuena-Delgado, J.F. Valdés Galicia, I. Valiño, L. Valore, G. van Aar, P. van Bodegom, A.M. van den Berg, A. van Vliet, E. Varela, B. Vargas Cárdenas, G. Varner, J.R. Vázquez, R.A. Vázquez, D. Veberič, V. Verzi, J. Vicha, L. Villaseñor, S. Vorobiov, H. Wahlberg, O. Wainberg, D. Walz, A.A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, T. Winchen, D. Wittkowski, B. Wundheiler, S. Wykes, L. Yang, D. Yelos, P. Younk, A. Yushkov, E. Zas, D. Zavrtanik, M. Zavrtanik, A. Zepeda, B. Zimmermann, M. Ziolkowski, Z. Zong, and F. Zuccarello

Subjects
Physics, QC1-999
Abstract

We report a first measurement for ultrahigh energy cosmic rays of the correlation between the depth of shower maximum and the signal in the water Cherenkov stations of air-showers registered simultaneously by the fluorescence and the surface detectors of the Pierre Auger Observatory. Such a correlation measurement is a unique feature of a hybrid air-shower observatory with sensitivity to both the electromagnetic and muonic components. It allows an accurate determination of the spread of primary masses in the cosmic-ray flux. Up till now, constraints on the spread of primary masses have been dominated by systematic uncertainties. The present correlation measurement is not affected by systematics in the measurement of the depth of shower maximum or the signal in the water Cherenkov stations. The analysis relies on general characteristics of air showers and is thus robust also with respect to uncertainties in hadronic event generators. The observed correlation in the energy range around the ‘ankle’ at lg⁡(E/eV)=18.5–19.0 differs significantly from expectations for pure primary cosmic-ray compositions. A light composition made up of proton and helium only is equally inconsistent with observations. The data are explained well by a mixed composition including nuclei with mass A>4. Scenarios such as the proton dip model, with almost pure compositions, are thus disfavored as the sole explanation of the ultrahigh-energy cosmic-ray flux at Earth. Keywords: Pierre Auger Observatory, Cosmic rays, Mass composition, Ankle

Published
2016
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13. Exposição por chumbo dos profissionais de segurança pública na região de Cascavel-PR

Author

V. de Souza, O. Korand, and A. C. Gonçalves Junior

Subjects
saúde do trabalhador, chumbo, contaminação, Agriculture (General), S1-972, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

EO objetivo desta pesquisa é mostrar os riscos a que estão expostos os profissionais de segurança pública. Sendo realizadas análises do solo do estande de tiro, verificandoos índices de contaminação por chumbo para apresentar o panorama atual de como está este ambiente utilizado pelos policiais militares. .Este trabalho apresenta os resultados do monitoramento temporal do solo do estande de tiro da Polícia Militar localizado no município de Cascavel, Paraná, através de levantamento de amostras em duas campanhas realizadas nos anos de 2013 e 2015. Que consistiu na comparação dos resultados, executados nos mesmos locais. Obtendo-se assim os teores de chumbo tendo em vista a deposição de projéteis de arma de fogo no solo do estande. Foi possível avaliar o grau de contaminação existente e comparar com a determinação legal da Resolução 420 do CONAMA que estabelece os níveis aceitáveis ou não de chumbo no solo. Os índices de teores de chumbo apresentados demonstram que os profissionais de segurança pública, em particular os policiais militares, podem estar expostos à contaminação e assim devem ser tomadas medidas de remediação conforme a prevê a legislação vigente. Lead exposure in the professional public safety region Cascavel-PR Abstract: The objective of this research is to show the risks they are public safety workers exposed. Being from the shooting range soil analyzes, verifying the lead contamination indexes to present the current situation of how this environment is used by police. This paper presents the results of temporal monitoring of soil Military Police firing range located in Cascavel, Paraná, through a survey samples in two campaigns conducted in the years 2013 and 2015. That was the comparison of results, performed in same places. Thus yielding the lead content in view of the deposition of firearm projectiles in the soil of the stand. It was possible to evaluate the degree of contamination and compare with the legal requirements of Resolution 420 of CONAMA establishing acceptable levels or absence of lead in soil. The lead content ratios presented show that the public safety professionals, particularly the military police, may be exposed to contamination and thus should be taken remedial measures as the current legislation provides.

Published
2015
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14. DETECTION OF A CHANGE OF SLOPE IN THE SPECTRUM OF HEAVY MASS COSMIC RAYS PRIMARIES BY THE KASCADE-GRANDE EXPERIMENT

Author

A. Chiavassa, W. D. Apel, J. C. Arteaga-Velázquez, K. Bekk, M. Bertaina, J. Blümer, H. Bozdog, I. M. Brancus, E. Cantoni, F. Cossavella, K. Daumiller, V. de Souza, F. Di Pierro, P. Doll, R. Engel, J. Engler, M. Finger, B. Fuchs, D. Fuhrmann, F. Garino, H. J. Gils, R. Glasstetter, C. Grupen, A. Haungs, D. Heck, J. R. Hörandel, D. Huber, T. Huege, K.-H. Kampert, D. Kang, H. O. Klages, K. Link, P. Łuczak, M. Ludwig, H. J. Mathes, H. J. Mayer, M. Melissas, J. Milke, B. Mitrica, C. Morello, J. Oehlschläger, S. Ostapchenko, N. Palmieri, M. Petcu, T. Pierog, H. Rebel, M. Roth, H. Schieler, S. Schoo, F. G. Schröder, O. Sima, G. Toma, G. C. Trinchero, H. Ulrich, A. Weindl, J. Wochele, M. Wommer, and J. Zabierowski

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

KASCADE-Grande is an extensive air shower experiment devoted to the study of cosmic rays in the 1016 ÷ 1018 eV energy range. The array is composed by different detectors allowing independent measurements of the number of muons (Nμ) and charged particles (Nch) of extensive air showers (EAS). These two observables are then used to study the primary energy spectrum, separating the events in two samples, on the basis of the shower size ratio, corrected for attenuation in the atmosphere, lnNμ/ lnNch. The two samples represent the light and heavy mass groups of the primaries. In the studied energy range only the spectrum of heavy primaries shows a significant change of slope, the energy (estimated using the QGSJET II hadronic interaction model) of this feature is in agreeement with the expectations of a rigidity dependent knee feature.

Published
2013
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15. Ultrahigh Energy Neutrinos at the Pierre Auger Observatory

Author

P. Abreu, M. Aglietta, M. Ahlers, E. J. Ahn, I. F. M. Albuquerque, D. Allard, I. Allekotte, J. Allen, P. Allison, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, R. Alves Batista, M. Ambrosio, A. Aminaei, L. Anchordoqui, S. Andringa, T. Antičić, C. Aramo, E. Arganda, F. Arqueros, H. Asorey, P. Assis, J. Aublin, M. Ave, M. Avenier, G. Avila, T. Bäcker, A. M. Badescu, M. Balzer, K. B. Barber, A. F. Barbosa, R. Bardenet, S. L. C. Barroso, B. Baughman, J. Bäuml, J. J. Beatty, B. R. Becker, K. H. Becker, A. Bellétoile, J. A. Bellido, S. BenZvi, C. Berat, X. Bertou, P. L. Biermann, P. Billoir, F. Blanco, M. Blanco, C. Bleve, H. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, R. Bonino, N. Borodai, J. Brack, I. Brancus, P. Brogueira, W. C. Brown, R. Bruijn, P. Buchholz, A. Bueno, R. E. Burton, K. S. Caballero-Mora, B. Caccianiga, L. Caramete, R. Caruso, A. Castellina, O. Catalano, G. Cataldi, L. Cazon, R. Cester, J. Chauvin, S. H. Cheng, A. Chiavassa, J. A. Chinellato, J. Chirinos Diaz, J. Chudoba, M. Cilmo, R. W. Clay, M. R. Coluccia, R. Conceição, F. Contreras, H. Cook, M. J. Cooper, J. Coppens, A. Cordier, S. Coutu, C. E. Covault, A. Creusot, A. Criss, J. Cronin, A. Curutiu, S. Dagoret-Campagne, R. Dallier, B. Daniel, S. Dasso, K. Daumiller, B. R. Dawson, R. M. de Almeida, M. De Domenico, C. De Donato, S. J. de Jong, G. De La Vega, W. J. M. de Mello Junior, J. R. T. de Mello Neto, I. De Mitri, V. de Souza, K. D. de Vries, L. del Peral, M. del Río, O. Deligny, H. Dembinski, N. Dhital, C. Di Giulio, M. L. Díaz Castro, P. N. Diep, F. Diogo, C. Dobrigkeit, W. Docters, J. C. D'Olivo, P. N. Dong, A. Dorofeev, J. C. dos Anjos, M. T. Dova, D. D'Urso, I. Dutan, J. Ebr, R. Engel, M. Erdmann, C. O. Escobar, J. Espadanal, A. Etchegoyen, P. Facal San Luis, H. Falcke, G. Farrar, A. C. Fauth, N. Fazzini, A. P. Ferguson, B. Fick, A. Filevich, A. Filipčič, S. Fliescher, C. E. Fracchiolla, E. D. Fraenkel, O. Fratu, U. Fröhlich, B. Fuchs, R. Gaior, R. F. Gamarra, S. Gambetta, B. García, S. T. Garcia Roca, D. Garcia-Gamez, D. Garcia-Pinto, A. Gascon Bravo, H. Gemmeke, P. L. Ghia, M. Giller, J. Gitto, H. Glass, M. S. Gold, G. Golup, F. Gomez Albarracin, M. Gómez Berisso, P. F. Gómez Vitale, P. Gonçalves, J. G. Gonzalez, B. Gookin, A. Gorgi, P. Gouffon, E. Grashorn, S. Grebe, N. Griffith, M. Grigat, A. F. Grillo, Y. Guardincerri, F. Guarino, G. P. Guedes, P. Hansen, D. Harari, T. A. Harrison, J. L. Harton, A. Haungs, T. Hebbeker, D. Heck, A. E. Herve, C. Hojvat, N. Hollon, V. C. Holmes, P. Homola, J. R. Hörandel, P. Horvath, M. Hrabovský, D. Huber, T. Huege, A. Insolia, F. Ionita, A. Italiano, C. Jarne, S. Jiraskova, M. Josebachuili, K. Kadija, K. H. Kampert, P. Karhan, P. Kasper, I. Katkov, B. Kégl, B. Keilhauer, A. Keivani, J. L. Kelley, E. Kemp, R. M. Kieckhafer, H. O. Klages, M. Kleifges, J. Kleinfeller, J. Knapp, D.-H. Koang, K. Kotera, N. Krohm, O. Krömer, D. Kruppke-Hansen, F. Kuehn, D. Kuempel, J. K. Kulbartz, N. Kunka, G. La Rosa, C. Lachaud, D. LaHurd, L. Latronico, R. Lauer, P. Lautridou, S. Le Coz, M. S. A. B. Leão, D. Lebrun, P. Lebrun, M. A. Leigui de Oliveira, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, R. López, A. Lopez Agüera, K. Louedec, J. Lozano Bahilo, L. Lu, A. Lucero, M. Ludwig, H. Lyberis, M. C. Maccarone, C. Macolino, S. Maldera, D. Mandat, P. Mantsch, A. G. Mariazzi, J. Marin, V. Marin, I. C. Maris, H. R. Marquez Falcon, G. Marsella, D. Martello, L. Martin, H. Martinez, O. Martínez Bravo, H. J. Mathes, J. Matthews, J. A. J. Matthews, G. Matthiae, D. Maurel, D. Maurizio, P. O. Mazur, G. Medina-Tanco, M. Melissas, D. Melo, E. Menichetti, A. Menshikov, P. Mertsch, C. Meurer, S. Mićanović, M. I. Micheletti, I. A. Minaya, L. Miramonti, L. Molina-Bueno, S. Mollerach, M. Monasor, D. Monnier Ragaigne, F. Montanet, B. Morales, C. Morello, E. Moreno, J. C. Moreno, M. Mostafá, C. A. Moura, M. A. Muller, G. Müller, M. Münchmeyer, R. Mussa, G. Navarra, J. L. Navarro, S. Navas, P. Necesal, L. Nellen, A. Nelles, J. Neuser, P. T. Nhung, M. Niechciol, L. Niemietz, N. Nierstenhoefer, D. Nitz, D. Nosek, L. Nožka, J. Oehlschläger, A. Olinto, M. Ortiz, N. Pacheco, D. Pakk Selmi-Dei, M. Palatka, J. Pallotta, N. Palmieri, G. Parente, E. Parizot, A. Parra, S. Pastor, T. Paul, M. Pech, J. Pękala, R. Pelayo, I. M. Pepe, L. Perrone, R. Pesce, E. Petermann, S. Petrera, A. Petrolini, Y. Petrov, C. Pfendner, R. Piegaia, T. Pierog, P. Pieroni, M. Pimenta, V. Pirronello, M. Platino, M. Plum, V. H. Ponce, M. Pontz, A. Porcelli, P. Privitera, M. Prouza, E. J. Quel, S. Querchfeld, J. Rautenberg, O. Ravel, D. Ravignani, B. Revenu, J. Ridky, S. Riggi, M. Risse, P. Ristori, H. Rivera, V. Rizi, J. Roberts, W. Rodrigues de Carvalho, G. Rodriguez, I. Rodriguez Cabo, J. Rodriguez Martino, J. Rodriguez Rojo, M. D. Rodríguez-Frías, G. Ros, J. Rosado, T. Rossler, M. Roth, B. Rouillé-d'Orfeuil, E. Roulet, A. C. Rovero, C. Rühle, A. Saftoiu, F. Salamida, H. Salazar, F. Salesa Greus, G. Salina, F. Sánchez, C. E. Santo, E. Santos, E. M. Santos, F. Sarazin, B. Sarkar, S. Sarkar, R. Sato, N. Scharf, V. Scherini, H. Schieler, P. Schiffer, A. Schmidt, O. Scholten, H. Schoorlemmer, J. Schovancova, P. Schovánek, F. Schröder, S. Schulte, D. Schuster, S. J. Sciutto, M. Scuderi, A. Segreto, M. Settimo, A. Shadkam, R. C. Shellard, I. Sidelnik, G. Sigl, O. Sima, A. Śmiałkowski, R. Šmída, G. R. Snow, P. Sommers, J. Sorokin, H. Spinka, R. Squartini, Y. N. Srivastava, S. Stanic, J. Stapleton, J. Stasielak, M. Stephan, A. Stutz, F. Suarez, T. Suomijärvi, A. D. Supanitsky, T. Šuša, M. S. Sutherland, J. Swain, Z. Szadkowski, M. Szuba, A. Tapia, M. Tartare, O. Taşcău, R. Tcaciuc, N. T. Thao, D. Thomas, J. Tiffenberg, C. Timmermans, W. Tkaczyk, C. J. Todero Peixoto, G. Toma, L. Tomankova, B. Tomé, A. Tonachini, P. Travnicek, D. B. Tridapalli, G. Tristram, E. Trovato, M. Tueros, R. Ulrich, M. Unger, M. Urban, J. F. Valdés Galicia, I. Valiño, L. Valore, A. M. van den Berg, E. Varela, B. Vargas Cárdenas, J. R. Vázquez, R. A. Vázquez, D. Veberič, V. Verzi, J. Vicha, M. Videla, L. Villaseñor, H. Wahlberg, P. Wahrlich, O. Wainberg, D. Walz, A. A. Watson, M. Weber, K. Weidenhaupt, A. Weindl, F. Werner, S. Westerhoff, B. J. Whelan, A. Widom, G. Wieczorek, L. Wiencke, B. Wilczyñska, H. Wilczyñski, M. Will, C. Williams, T. Winchen, M. Wommer, B. Wundheiler, T. Yamamoto, T. Yapici, P. Younk, G. Yuan, A. Yushkov, B. Zamorano Garcia, E. Zas, D. Zavrtanik, M. Zavrtanik, I. Zaw, A. Zepeda, Y. Zhu, M. Zimbres Silva, and M. Ziolkowski

Subjects
Physics, QC1-999
Abstract

The observation of ultrahigh energy neutrinos (UHEνs) has become a priority in experimental astroparticle physics. UHEνs can be detected with a variety of techniques. In particular, neutrinos can interact in the atmosphere (downward-going ν) or in the Earth crust (Earth-skimming ν), producing air showers that can be observed with arrays of detectors at the ground. With the surface detector array of the Pierre Auger Observatory we can detect these types of cascades. The distinguishing signature for neutrino events is the presence of very inclined showers produced close to the ground (i.e., after having traversed a large amount of atmosphere). In this work we review the procedure and criteria established to search for UHEνs in the data collected with the ground array of the Pierre Auger Observatory. This includes Earth-skimming as well as downward-going neutrinos. No neutrino candidates have been found, which allows us to place competitive limits to the diffuse flux of UHEνs in the EeV range and above.

Published
2013
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16. The physical and chemical structure of high-mass star-forming regions. Unraveling chemical complexity with the NOEMA large program 'CORE'

Author

Gieser, C., Beuther, H., Semenov, D., Ahmadi, A., Suri, S., Möller, T., Beltran, M. T., Klaassen, P., Zhang, Q., Urquhart, J. S., Henning, Th., Feng, S., Galván-Madrid, R., Magalhães, V. de Souza, Moscadelli, L., Longmore, S., Leurini, S., Kuiper, R., Peters, T., Menten, K. M., Csengeri, T., Fuller, G., Wyrowski, F., Lumsden, S., Sánchez-Monge, Á., Maud, L., Linz, H., Palau, A., Schilke, P., Pety, J., Pudritz, R., Winters, J. M., and Piétu, V.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

We use sub-arcsecond resolution ($\sim$0.4$''$) observations with NOEMA at 1.37 mm to study the dust emission and molecular gas of 18 high-mass star-forming regions. We combine the derived physical and chemical properties of individual cores in these regions to estimate their ages. The temperature structure of these regions are determined by fitting H2CO and CH3CN line emission. The density profiles are inferred from the 1.37 mm continuum visibilities. The column densities of 11 different species are determined by fitting the emission lines with XCLASS. Within the 18 observed regions, we identify 22 individual cores with associated 1.37 mm continuum emission and with a radially decreasing temperature profile. We find an average temperature power-law index of q = 0.4$\pm$0.1 and an average density power-law index of p = 2.0$\pm$0.2 on scales on the order of several 1 000 au. Comparing these results with values of p derived in the literature suggest that the density profiles remain unchanged from clump to core scales. The column densities relative to N(C18O) between pairs of dense gas tracers show tight correlations. We apply the physical-chemical model MUSCLE to the derived column densities of each core and find a mean chemical age of $\sim$60 000 yrs and an age spread of 20 000-100 000 yrs. With this paper we release all data products of the CORE project available at https://www.mpia.de/core. The CORE sample reveals well constrained density and temperature power-law distributions. Furthermore, we characterize a large variety in molecular richness that can be explained by an age spread confirmed by our physical-chemical modeling. The hot molecular cores show the most emission lines, but we also find evolved cores at an evolutionary stage, in which most molecules are destroyed and thus the spectra appear line-poor again., Comment: 29 pages, 14 figures, accepted for publication in A&A

Published
2021
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17. CLASSIFICATION OF BANANA RIPENING STAGES BY ARTIFICIAL NEURAL NETWORKS AS A FUNCTION OF PLANT PHYSICAL, PHYSICOCHEMICAL, AND BIOCHEMICAL PARAMETERS

Author

Alfredo Bonini Neto, Angela V. de Souza, Carolina dos S. B. Bonini, Jéssica M. de Mello, and Adonis Moreira

Subjects
Artificial intelligence, estimation, mathematical modeling, banana stages, Agriculture (General), S1-972
Abstract

ABSTRACT Brazil is currently the 4th world’s largest banana producer, producing around 7 million tons. In this scenario, several studies have been developed with a large amount of data, such as climatic, morphological, and nutritional data, in an attempt to improve these numbers even further. This study aims to classify banana ripening stages by artificial neural networks (ANN) as a function of plant physical, physicochemical, and biochemical parameters. The used ANN consisted of a three-layer feedforward backpropagation network, with eight neurons in the input layer (physical, physicochemical, and biochemical parameters), ten neurons in the intermediate layer, and two neurons in the output layer (classification of banana ripening stages). The results showed three configurations. ANN presented an excellent result for the training phase, with 100% accuracy in the sample classification for the three configurations. The validation and testing phases, that is, the classification of samples that were not part of the training, showed 91.6% and 94.4% accuracy in the first and second configurations, respectively, and 89.5% accuracy in the third configuration.

Published
2022
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18. Food content on children movies from 2013 to 2018: taking food processing into account

Author

Paula M. Horta, Bárbara B. Machado, and Liziane V. de Souza

Subjects
Children, Movies, Ultra-processed foods, Food environment, Pediatrics, RJ1-570
Abstract

Objective: Movies and TV programs directed to children contain food information that can potentially negative influence their food consumption. The NOVA classification is a useful system for monitoring food informational environment. Therefore, this study aimed to evaluate food content on children movies using the NOVA classification. Methods: The 13 top box office children movies released from 2013 to 2018 were evaluated. Each food reference was classified as unprocessed or minimally processed, processed and ultra-processed food (UPF) and as positive, negative, and neutral message transmitted. Results: One hundred and ninety-eight (n = 198) scenes that contained 555 food references were included. The frequency of references to unprocessed and minimally processed foods (60.1%) was similar to references of UPF (59.1%). Fruit/vegetables and sweets represented 37.9% of food appearances each. Scenes containing fruit/vegetables conveyed more negative (62.5%) or neutral messages (49.3%) than positive (26.4%). UPF scenes contained more positive (70.9%) and negative content (75.0%) than neutral (37.3%). Regarding UPF subcategories, sweets scenes were more positive (49.1%) than neutral (22.4%) and fast food meals scenes were more negative (37.5%) than neutral (5.9%). Conclusions: UPF, unprocessed food, and minimally processed foods have similar frequency in the movies. Except for fast food meals, UPF were commonly more associated with positive situations and unprocessed and minimally processed foods were more commonly associated with negative contexts.

Published
2021
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19. Survival of the copepod Mesocyclops longisetus during simulations of transport from hatchery to target areas for biological control of mosquito larvae

Author

Aline Nunes-Silva, Isabela de Lima-Keppe, Robson V. de Souza, and Gilmar Perbiche-Neves

Subjects
Zoology, QL1-991
Abstract

Copepods have been successfully used in many countries for the biological control of larvae of mosquitoes that vector diseases. In Brazil, this line of research has been focused on the use of the copepod Mesocyclops longisetus (Thiébaud, 1914) for the biological control of the mosquito Aedes aegypti (Linnaeus, 1792). The transportation of the copepods from the place where they are reared to where they will be used often involves long distances for extended periods of time. This study assesses the survivorship of M. longisetus during simulation of transport under different conditions. Different loading densities (20, 30, 40, 80, and 120 ind.L) and stirring times (30 minutes, one hour, two hours, and four hours) were tested. Survivorship was high, with 75% of the results equal or higher than 90% survival. Reduced mortality was observed when transportation time was up to 120 minutes and densities were up to 40 ind.L. In higher densities or longer transportation times, the mortality rate was significantly affected.

Published
2020
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22. New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems

Author

Nicolas Duchemin, Sidonie Aubert, João V. de Souza, Lucas Bethge, Stefan Vonhoff, Agnieszka K. Bronowska, Michael Smietana, and Stellios Arseniyadis

Abstract

By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asymmetric catalysis, many challenges still remain to be faced, in particular when it comes to designing a "universal" catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asymmetric catalysis.

Published
2022

23. Particleboards manufactured from Tectona grandis wood waste with homogeneous and three-layer heterogeneous compositions for commercial purposes

Author

Matheus V. de Souza, Sérgio A. M. da Silva, Pedro H. S. Cazella, Felipe R. Rodrigues, Kely S. Bonfim, Alex O. Sanches, Victor A. De Araujo, Herisson F. dos Santos, Edna M. Pinto, André L. Christoforo, Márcia R. M. Aouada, Fauze A. Aouada, and Francisco A. R. Lahr

Subjects
Environmental Engineering, Bioengineering, Waste Management and Disposal, ESTRUTURAS
Abstract

Tectona grandis wood presents decent dimensional stability as well as highly suitable physical and mechanical properties. These characteristics have encouraged the intense usage of this species, which also includes the reuse of wood processing waste for panel production. Using teak wood waste, this study aims to manufacture and evaluate heat-pressed particleboards at 5 MPa and 100 °C, by being glued with castor oil-based polyurethane resin at proportions of 10% for the homogeneous boards and 12% for the heterogeneous solutions. Single-layer (homogeneous) boards were compared with three-layer particleboard specimens (heterogeneous) having the finer particles in the outer layers. The basic density, moisture content, modulus of rupture and modulus of elasticity in the static bending and perpendicular tensile, water absorption, and thickness swelling after 24 h were evaluated to support this comparative study. All the manufactured particleboards met the standardized requirements of performance, thus being very feasible for usage as non-structural boards. When the two different compositions were analyzed, a considerably better performance of the three-layered particleboards was identified when compared to the homogeneous panels.

Published
2022

25. Emotional, hyperactivity and inattention problems in adolescents with immunocompromising chronic diseases during the COVID-19 pandemic

Author

Reinan T. Campos, Livia Lindoso, Renan A. de Sousa, Alberto C. Helito, Bianca P. Ihara, Claudia A.A. Strabelli, Levi M.V. Paradelas, Beatriz O.L. Carneiro, Maria Paula R. Cardoso, Jean Paulo V. de Souza, Marianna R. de M. Freire, Camilla Astley, Moisés F. Laurentino, Izabel M. Buscatti, Katia Kozu, Nadia E. Aikawa, Adriana M.E. Sallum, Juliana C.O. Ferreira, Juliana R. Simon, Vivianne S.L. Viana, Ligia B. Queiroz, Bruno Gualano, Hamilton Roschel, Rosa Maria R. Pereira, Ricardo K. Toma, Andréia Watanabe, Patricia M. Grangeiro, Caio B. Casella, Sylvia C. Farhat, Guilherme V. Polanczyk, Lucia Maria A. Campos, and Clovis A. Silva

Subjects
Adolescent, COVID-19, Mental health, General Medicine, Chronic disease
Abstract

Objective: To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents with immunocompromising diseases. Methods: A cross-sectional study included 343 adolescents with immunocompromising diseases and 108 healthy adolescents. Online questionnaires were answered including socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and validated surveys: Strengths and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results: The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were similar to those of healthy subjects (110/343 [32%] vs. 38/108 [35%], p = 0.548), as well as abnormal hyperactivity/inattention SDQ scores (79/343 [23%] vs. 29/108 [27%], p = 0.417). Logistic regression analysis of independent variables associated with abnormal emotional scores from adolescents with chronic diseases showed: female sex (Odds Ratio [OR = 3.76]; 95% Confidence Interval (95% CI) 2.00–7.05; p < 0.001), poor sleep quality (OR = 2.05; 95% CI 1.08–3.88; p = 0.028) and intrafamilial violence during pandemic (OR = 2.17; 95% CI 1.12–4.19; p = 0.021) as independently associated with abnormal emotional scores, whereas total PedsQL score was inversely associated with abnormal emotional scores (OR = 0.95; 95% CI 0.93–0.96; p < 0.0001). Logistic regression analysis associated with abnormal HI scores from patients evidenced that total PedsQL score (OR = 0.97; 95% CI 0.95–0.99; p = 0.010], changes in medical appointments during the pandemic (OR = 0.39; 95% CI 0.19–0.79; p = 0.021), and reliable COVID-19 information (OR = 0.35; 95% CI 0.16–0.77; p = 0.026) remained inversely associated with abnormal HI scores. Conclusion: The present study showed emotional and HI disturbances in adolescents with chronic immunosuppressive diseases during the COVID-19 pandemic. It reinforces the need to promptly implement a longitudinal program to protect the mental health of adolescents with and without chronic illnesses during future pandemics.

Published
2023

27. Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain and Modulation via Direct Interactions with DNA Abasic Sites: Understanding the Mechanisms Involved in Castration-Resistant Prostate Cancer

Author

Shangze Xu, Matthew D. Kondal, Ayaz Ahmad, Ruidi Zhu, Lanyu Fan, Piotr Zaborniak, Katrina S. Madden, João V. de Souza, and Agnieszka K. Bronowska

Subjects
Inorganic Chemistry, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, androgen receptor, castration-resistant prostate cancer, dimerisation, molecular dynamics simulations, protein-protein interactions, DNA-protein interactions, DNA-protein adducts, Molecular Biology, Spectroscopy, Catalysis, Computer Science Applications
Abstract

The androgen receptor (AR) is an important drug target in prostate cancer and a driver of castration-resistant prostate cancer (CRPC). A significant challenge in designing effective drugs lies in targeting constitutively active AR variants and, most importantly, nearly all AR variants lacking the ligand-binding domain (LBD). Recent findings show that an AR’s constitutive activity may occur in the presence of somatic DNA mutations within non-coding regions, but the role of these mutations remains elusive. The discovery of new drugs targeting CRPC is hampered by the limited molecular understanding of how AR binds mutated DNA sequences, frequently observed in prostate cancer, and how mutations within the protein and DNA regulate AR-DNA interactions. Using atomistic molecular dynamics (MD) simulations and quantum mechanical calculations, we focused our efforts on (i) rationalising the role of several activating DBD mutations linked to prostate cancer, and (ii) DBD interactions in the presence of abasic DNA lesions, which frequently occur in CRPC. Our results elucidate the role of mutations within DBD through their modulation of the intrinsic dynamics of the DBD-DNA ternary complex. Furthermore, our results indicate that the DNA apurinic lesions occurring in the androgen-responsive element (ARE) enhance direct AR-DNA interactions and stabilise the DBD homodimerisation interface. Moreover, our results strongly suggest that those abasic lesions may form reversible covalent crosslinks between DNA and lysine residues of an AR via a Schiff base. In addition to providing an atomistic model explaining how protein mutations within the AR DNA-binding domain affect AR dimerisation and AR-DNA interactions, our findings provide insight into how somatic mutations occurring in DNA non-coding regions may activate ARs. These mutations are frequently observed in prostate cancer and may contribute to disease progression by enhancing direct AR-DNA interactions.

Published
2023
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28. Sensitivity of the Cherenkov Telescope Array to TeV photon emission from the Large Magellanic Cloud

Author

A Acharyya, R Adam, A Aguasca-Cabot, I Agudo, A Aguirre-Santaella, J Alfaro, R Aloisio, R Alves Batista, E Amato, E O Angüner, C Aramo, C Arcaro, K Asano, J Aschersleben, H Ashkar, M Backes, A Baktash, C Balazs, M Balbo, J Ballet, A Bamba, A Baquero Larriva, V Barbosa Martins, U Barres de Almeida, J A Barrio, D Bastieri, P Batista, I Batkovic, J R Baxter, J Becerra González, J Becker Tjus, W Benbow, E Bernardini, M I Bernardos Martín, J Bernete Medrano, A Berti, B Bertucci, V Beshley, P Bhattacharjee, S Bhattacharyya, C Bigongiari, A Biland, E Bissaldi, F Bocchino, P Bordas, J Borkowski, E Bottacini, M Böttcher, F Bradascio, A M Brown, A Bulgarelli, L Burmistrov, S Caroff, A Carosi, E Carquín, S Casanova, E Cascone, F Cassol, M Cerruti, P Chadwick, S Chaty, A Chen, A Chiavassa, L Chytka, V Conforti, J Cortina, A Costa, H Costantini, G Cotter, S Crestan, P Cristofari, F D’Ammando, M Dalchenko, F Dazzi, A De Angelis, V De Caprio, E M de Gouveia Dal Pino, D De Martino, M de Naurois, V de Souza, M V del Valle, A G Delgado Giler, C Delgado, D della Volpe, D Depaoli, T Di Girolamo, A Di Piano, F Di Pierro, R Di Tria, L Di Venere, S Diebold, M Doro, D Dumora, V V Dwarkadas, C Eckner, K Egberts, G Emery, J Escudero, D Falceta-Goncalves, E Fedorova, S Fegan, Q Feng, D Ferenc, G Ferrand, E Fiandrini, M Filipovic, V Fioretti, L Foffano, G Fontaine, Y Fukui, D Gaggero, G Galanti, G Galaz, S Gallozzi, V Gammaldi, M Garczarczyk, C Gasbarra, D Gasparrini, A Ghalumyan, M Giarrusso, G Giavitto, N Giglietto, F Giordano, A Giuliani, J-F Glicenstein, P Goldoni, J Goulart Coelho, J Granot, D Green, J G Green, M-H Grondin, O Gueta, D Hadasch, P Hamal, T Hassan, K Hayashi, M Heller, S Hernández Cadena, N Hiroshima, B Hnatyk, R Hnatyk, W Hofmann, J Holder, M Holler, D Horan, P Horvath, M Hrabovsky, M Hütten, M Iarlori, T Inada, F Incardona, S Inoue, F Iocco, M Jamrozy, W Jin, I Jung-Richardt, J Juryšek, D Kantzas, V Karas, H Katagiri, D Kerszberg, J Knödlseder, N Komin, P Kornecki, K Kosack, G Kowal, H Kubo, A Lamastra, J Lapington, M Lemoine-Goumard, J-P Lenain, F Leone, G Leto, F Leuschner, E Lindfors, T Lohse, S Lombardi, F Longo, R López-Coto, A López-Oramas, S Loporchio, P L Luque-Escamilla, O Macias, P Majumdar, D Mandat, S Mangano, G Manicò, M Mariotti, P Marquez, G Marsella, J Martí, P Martin, M Martínez, D Mazin, S Menchiari, D M-A Meyer, D Miceli, M Miceli, J Michałowski, A Mitchell, R Moderski, L Mohrmann, M Molero, E Molina, T Montaruli, A Moralejo, D Morcuende, A Morselli, E Moulin, V Moya, R Mukherjee, K Munari, A Muraczewski, S Nagataki, T Nakamori, A Nayak, J Niemiec, M Nievas, M Nikołajuk, K Nishijima, K Noda, D Nosek, B Novosyadlyj, S Nozaki, M Ohishi, S Ohm, A Okumura, B Olmi, R A Ong, M Orienti, R Orito, M Orlandini, E Orlando, S Orlando, M Ostrowski, I Oya, A Pagliaro, M Palatka, F R Pantaleo, R Paoletti, J M Paredes, N Parmiggiani, B Patricelli, M Pech, M Pecimotika, M Persic, O Petruk, E Pierre, E Pietropaolo, G Pirola, M Pohl, E Prandini, C Priyadarshi, G Pühlhofer, M L Pumo, M Punch, F S Queiroz, A Quirrenbach, S Rainò, R Rando, S Razzaque, A Reimer, O Reimer, T Reposeur, M Ribó, T Richtler, J Rico, F Rieger, M Rigoselli, V Rizi, E Roache, G Rodriguez Fernandez, P Romano, G Romeo, J Rosado, A Rosales de Leon, B Rudak, C Rulten, I Sadeh, T Saito, M Sánchez-Conde, H Sano, A Santangelo, R Santos-Lima, S Sarkar, F G Saturni, A Scherer, P Schovanek, F Schussler, U Schwanke, O Sergijenko, M Servillat, H Siejkowski, C Siqueira, S Spencer, A Stamerra, S Stanič, C Steppa, T Stolarczyk, Y Suda, T Tavernier, M Teshima, L Tibaldo, D F Torres, N Tothill, M Vacula, B Vallage, P Vallania, C van Eldik, M Vázquez Acosta, M Vecchi, S Ventura, S Vercellone, A Viana, C F Vigorito, J Vink, V Vitale, V Vodeb, S Vorobiov, T Vuillaume, S J Wagner, R Walter, M White, A Wierzcholska, M Will, R Yamazaki, L Yang, T Yoshikoshi, M Zacharias, G Zaharijas, D Zavrtanik, M Zavrtanik, A A Zdziarski, V I Zhdanov, K Ziętara, M Živec, Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Cherenkov Telescope Array

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), photon, emission, acceleration, efficiency, Cherenkov Telescope Array, WIMP, diffusion, FOS: Physical sciences, Astronomy and Astrophysics, suppression, sensitivity, Navarro-Frenk-White profile, dark matter, photon, energy, flux, cosmic radiation, spectrum, energy, high, Space and Planetary Science, cloud, TeV, spectral, galaxy, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], nucleus, cosmic radiation
Abstract

A deep survey of the Large Magellanic Cloud at ~0.1-100TeV photon energies with the Cherenkov Telescope Array is planned. We assess the detection prospects based on a model for the emission of the galaxy, comprising the four known TeV emitters, mock populations of sources, and interstellar emission on galactic scales. We also assess the detectability of 30 Doradus and SN 1987A, and the constraints that can be derived on the nature of dark matter. The survey will allow for fine spectral studies of N157B, N132D, LMC P3, and 30 Doradus C, and half a dozen other sources should be revealed, mainly pulsar-powered objects. The remnant from SN 1987A could be detected if it produces cosmic-ray nuclei with a flat power-law spectrum at high energies, or with a steeper index 2.3-2.4 pending a flux increase by a factor >3-4 over ~2015-2035. Large-scale interstellar emission remains mostly out of reach of the survey if its >10GeV spectrum has a soft photon index ~2.7, but degree-scale 0.1-10TeV pion-decay emission could be detected if the cosmic-ray spectrum hardens above >100GeV. The 30 Doradus star-forming region is detectable if acceleration efficiency is on the order of 1-10% of the mechanical luminosity and diffusion is suppressed by two orders of magnitude within, Accepted for publication in MNRAS. Corresponding authors: Pierrick Martin, Maria Isabel Bernardos Martin, Fabio Iocco

Published
2023

29. Medicina Veterinaria Forense, Bienestar y Maltrato Animal: Percepciones y Conocimiento de Estudiantes de Medicina Veterinaria Colombianos y Brasileños

Author

Stefany Monsalve, Poliana V. de Souza, Alícia S. Lopes, Luana O. Leite, Gina Polo, and Rita Garcia

Subjects
General Veterinary, Animals, General Medicine, Education, Veterinary, Education
Abstract

Los médicos veterinarios juegan un papel fundamental en la detección de casos de maltrato animal y violencia doméstica. Por lo tanto, es esencial que las escuelas de medicina veterinaria brinden una formación adecuada en bienestar animal y medicina veterinaria forense. El objetivo del presente artículo es caracterizar la percepción y el conocimiento de los estudiantes de medicina veterinaria sobre la formación en medicina veterinaria forense, bienestar animal y la asociación entre maltrato animal y violencia humana. Un cuestionario online fue distribuido a los estudiantes de las 227 y 22 facultades de medicina veterinaria en Brasil y Colombia, respectivamente. Pruebas de chi-cuadrado fueron realizadas para comparar las respuestas de las variables categóricas entre los estudiantes de Brasil y Colombia. La mayoría de los estudiantes encuestados indicaron que su escuela ofrecía capacitación en bienestar animal. Sin embargo, solo el 21.8% (47/216) de los estudiantes colombianos y el 43.1% (216/523) de los brasileños mencionaron que su facultad ofrecía formación en medicina veterinaria forense. En ambos países fueron identificadas deficiencias en la capacitación sobre la identificación de traumas no accidentales, denuncia de maltrato animal y el conocimiento sobre la asociación entre maltrato animal y violencia interpersonal. A pesar de esto, más del 90% de los estudiantes relataron ser conscientes de la relación que existe entre estos dos crímenes y la importancia de recibir capacitación obligatoria sobre maltrato animal y medicina veterinaria forense. Adicionalmente, la mayoría de los encuestados reconocieron que el maltrato animal incluye tanto el abuso físico como el mental. Nuestros resultados destacan la necesidad de mejorar la educación en bienestar animal, maltrato animal, violencia humana y medicina veterinaria forense en las facultades de medicina veterinaria de Brasil y Colombia.

Published
2021

30. Comparison of nerve conduits and nerve graft in digital nerve regeneration: A systematic review and meta-analysis

Author

R. Mattiello, Bruna Leiria Meréje Leal, G.A. Magnus, J. Braga Silva, C.G. Wolff, and V. de Souza Stanham

Subjects
medicine.medical_specialty, business.industry, Regeneration (biology), Rehabilitation, Nerve graft, Prostheses and Implants, Outcome assessment, Placebo, Neurosurgical Procedures, Nerve Regeneration, Surgery, Peripheral, Lesion, Peripheral Nerve Injuries, Meta-analysis, Humans, Medicine, Orthopedics and Sports Medicine, Peripheral Nerves, Digital nerve, medicine.symptom, business
Abstract

The goal of this systematic review and meta-analysis was to compare nerve conduits and nerve graft for peripheral nerve regeneration. This type of lesion frequently causes disability due to pain, paresthesia and motor deficit. On the PICO process, "P" corresponded to patients with peripheral digital nerve lesions of any age, gender or ethnicity, "I" to interventions with nerve conduits or nerve graft, "C" to the control group with no treatment, placebo or receiving other treatment, and "O" to outcome assessment of nerve regeneration. Initial search found in 3859 studies, including 2001 duplicates. The remaining 1858 studies were selected by title and/or abstract; 1798 articles were excluded, leaving 60 articles for full-text review. Thirty-nine of these 60 reports were excluded as not meeting our inclusion criteria, and 21 articles were ultimately included in the systematic review. For patients older than 40 years, there was a greater mean improvement on S2PD and M2PD tests with grafting, which seemed to be the better surgical technique, positively impacting prognosis. On the M2PD test, there was significantly greater improvement in 11-17.99 mm defects with grafting (P 0.001); this finding should guide surgical strategy in peripheral nerve regeneration, to ensure better outcomes.

Published
2021

31. Do hurricanes or freezing events regulate the sustainability of subtropical mangroves on the Gulf of Mexico coast?

Author

Marcelo Cohen, Qiang Yao, Adriana V. de Souza, Kam-biu Liu, Sergio Nunes, Erika Rodrigues, Luiz C.R. Pessenda, and Nicholas Culligan

Abstract

Global warming has caused poleward mangrove expansion, but extreme climatic events have significantly impacted the mangroves along their boreal limits. This study aimed to determine which natural hazard is more important in limiting the sustainability and survival of subtropical black mangroves—hurricanes or freezing events? Satellite and drone images indicated Hurricanes Zeta and Ida (2020 – 2021) caused only minor damage to Avicennia trees (~5%, 6.32 ha) compared with the extensive mortality caused by the winter freeze of Dec/2017- Jan/2018 (~ 89%, 110 ha) at Port Fourchon, Louisiana. However, mangroves impacted by winter freezes had a faster recovery (~1 year), while the losses of mangrove areas by hurricanes are longer-lasting. This finding is novel and important because it implies that subtropical mangroves have low resistance but high resilience to winter freezes, while these forests present high resistance but low resilience to hurricanes. Overwash processes driven by hurricanes are the primary threat to mangroves at Port Fourchon due to the high rate of beach barrier retreat, which causes the burial of the back-barrier wetlands. In 2022 a new beach renourishment project is currently underway, resulting in shoreline progradation. This human intervention is essential to guarantee the stability of the beach barrier and slow down the increased losses of mangrove and salt marsh areas caused by sea level rise and extreme events. The mangrove at Port Fourchon is a microcosm of the general ecological balance of mangroves growing along their northern distribution limit. Thus, our findings apply to the coastal wetlands on the entire northern Gulf of Mexico.

Published
2022

33. Subacute thyroiditis and thyroid inflammatory nodule secondary to COVID-19: a primary care case report

Author

Clarissa V, de Souza, Patricia C C, Motta, Albanett B, Nestor, Renee, Coifman, and Marcelo M P, Demarzo

Abstract

To describe a case of subacute thyroiditis (SAT) secondary to COVID-19 in the primary health care (PHC).A 51-year-old woman was treated in a PHC facility for flu-like symptoms for 5 days and pain in the lower neck. Symptomatic drugs were prescribed, and the patient was tested for COVID-19. On reassessment, the patient presented a painful oedema on the thyroid gland, dysphagia, and improvement in flu-like symptoms. Nonsteroidal anti-inflammatories were prescribed, and thyroid function analysis and inflammatory markers were collected. Reassessment after 1 week showed positive polymerase chain reaction-rapid test for COVID-19, partial improvement of neck pain, alterations in thyroid hormone tests (suppressed thyroid stimulating hormone and slightly elevated T4), and elevated C-reactive protein. Thyroid gland ultrasonography (USG), anti-thyroglobulin, and anti-thyroid peroxidise (anti-TPO) antibodies were requested and prednisone was prescribed. Anti-thyroglobulin and anti-TPO antibodies were negative; thyroid USG showed a solid nodule in the left lobe (approximately 4 cm), classified as TIRADS-4. The patient was sent to the Endocrinology Service, and a thyroid fine needle aspiration was requested. USG prior to the examination evidenced a complete regression of the nodule, which was diagnosed as an inflammatory pseudo nodule.We presented the case of a patient who was treated in a PHC facility for rare findings of SAT secondary to mild COVID-19, concomitant with a thyroid nodule that had complete remission after approximately 3 months and was interpreted as an inflammatory pseudo nodule secondary to SAT. PHC professionals should be aware of this condition and conduct adequate follow-up of these patients.

Published
2022

35. TOCSY, hydrogen decoupling and computational calculations to an unequivocal structural elucidation of a new sesquiterpene derivative and identification of other constituents from Praxelis sanctopaulensis

Author

Cleverton S. Fernandes, Beatriz Pereira Moreno, Alana C. Battistella, Ernani A. Basso, Maria Helena Sarragiotto, Débora Larissa Oliveira Araújo, Debora Cristina Baldoqui, Ana Paula Lopes, João V. Daufemback, Maria E. V. de Souza, Marta Regina Barrotto do Carmo, Jesuí Vergílio Visentainer, Anderson V. G. Ramos, Solange Maria Cottica, and Tatiana Shioji Tiuman

Subjects
Magnetic Resonance Spectroscopy, DPPH, Ethyl acetate, Plant Science, Asteraceae, Tandem mass spectrometry, Sesquiterpene, Biochemistry, High-performance liquid chromatography, Antioxidants, Gas Chromatography-Mass Spectrometry, Analytical Chemistry, chemistry.chemical_compound, Cadinene, Drug Discovery, Chromatography, High Pressure Liquid, Chromatography, Plant Extracts, General Medicine, Complementary and alternative medicine, chemistry, Phytochemical, Molecular Medicine, Gas chromatography, Sesquiterpenes, Hydrogen, Food Science
Abstract

INTRODUCTION Praxelis genus comprises 24 species, however, only two species of this genus have been chemically investigated. Here we investigated Praxelis sanctopaulensis, a native plant from Brazil, that occurs mainly in Cerrado regions. OBJECTIVE The goal was to identify the specialised metabolites from P. sanctopaulensis, and compare with those described from Praxelis and Chromolaena species. METHODS The phytochemical study of P. sanctopaulensis was performed through different chromatography techniques, including high-performance liquid chromatography (HPLC), gas chromatography flame ionisation detector (GC-FID), and ultra-high-performance liquid chromatography high-resolution tandem mass spectrometry (UHPLC-HRMS/MS). The structures of the compounds were established based on spectroscopic analysis, total correlated spectroscopy (TOCSY), hydrogen decoupling and computational calculations was used to an unequivocal structural elucidation of a new sesquiterpene. The antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP), and antimicrobial assay was performed by the microdilution method. Comparison of the flavonoids described P. sanctopaulensis was carried out using principal component analysis. RESULTS The phytochemical investigation of P. sanctopaulensis led to the isolation of a pair of diastereomers, praxilone A and praxilone B. Seven known compounds were isolated from this species, another 14 fatty acids were detected in hexane fraction, and 26 compounds were identified from ethyl acetate fraction. All these compounds are being described for the first time in this species, with the exception of viridifloric acid. The ethyl acetate fraction showed potent antioxidant activity. CONCLUSIONS Forty-seven compounds are described from P. sanctopaulensis. The combination of different techniques of nuclear magnetic resonance (NMR) spectroscopy and computational calculations allowed the unequivocal structure elucidation of a new cadinene. The clustering analysis showed similarities between the flavonoids identified in P. sanctopaulensis and in Chromolaena species.

Published
2021

36. Effects of the middle Holocene high sea‐level stand and climate on Amazonian mangroves

Author

Marianne Dietz, Paloma Maria Pinto Camargo, Flávio Lima Lorente, Luiz Carlos Ruiz Pessenda, Adriana V. de Souza, Marcelo Cancela Lisboa Cohen, José Albertino Bendassolli, and José Augusto Martins Corrêa

Subjects
Oceanography, Arts and Humanities (miscellaneous), Stable isotope ratio, Pollen, Amazonian, Earth and Planetary Sciences (miscellaneous), medicine, Paleontology, Environmental science, Mangrove, medicine.disease_cause, Sea level, Holocene
Published
2021

37. An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

Author

Lan Z. Wang, Miller Duncan Charles, Bernard T. Golding, Ian Hickson, Martin E.M. Noble, Celine Cano, Suzannah J. Harnor, Michael J. Waring, Harry J Shrives, Shaimaa Khalifa, Jane Totobenazara, Stephen J. Hobson, Elaine Willmore, Hannah L Stewart, Mathew P. Martin, Susan J. Tudhope, Huw D. Thomas, Islam Al-Khawaldeh, Claire E. Jennings, João V de Souza, Max J. Temple, Jane A. Endicott, Cinzia Bordoni, Honorine Lebraud, Agnieszka K. Bronowska, Ian R. Hardcastle, Amy B. Heptinstall, Stephen R. Wedge, Christine Basmadjian, Gregory G Aldred, Julie A. Tucker, and Mohammed J Al Yasiri

Subjects
chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, Active site, Protein Serine-Threonine Kinases, Structure-Activity Relationship, Residue (chemistry), Pyrimidines, Enzyme, Biochemistry, Covalent bond, Alkynes, Drug Discovery, Cancer cell, biology.protein, Humans, Molecular Medicine, Kinome, Cysteine, Protein Kinase Inhibitors
Abstract

NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug target requires potent and selective inhibitors. The protein contains a cysteine residue at position 444 in the back pocket of the active site, unique within the kinome. Analysis of existing inhibitor scaffolds and early structure-activity relationships (SARs) led to the design of C444-targeting covalent inhibitors based on alkynyl heterocycle warheads. Mass spectrometry provided proof of the covalent mechanism, and the SAR was rationalized by computational modeling. Profiling of more potent analogues in tumor cell lines with constitutively activated NIK signaling induced a weak antiproliferative effect, suggesting that kinase inhibition may have limited impact on cancer cell growth. This study shows that alkynyl heterocycles are potential cysteine traps, which may be employed where common Michael acceptors, such as acrylamides, are not tolerated.

Published
2021

38. Mixture of noises and sampling of non-log-concave posterior distributions

Author

Pierre Palud, Pierre Chainais, Franck Le Petit, Emeric Bron, Pierre-Antoine Thouvenin, Maxime Vono, L. Einig, M. Garcia Santa-Maria, M. Gaudel, J. H. Orkisz, V. de Souza Magalhaes, S. Bardeau, M. Gerin, J. R. Goicoechea, P. Gratier, V. V. Guzman, J. Kainulainen, F. Levrier, N. Peretto, J. Pety, A. Roueff, and A. Sievers

Published
2022

40. Drugs and Endogenous Factors as Protagonists in Neurogenic Stimulation

Author

Raphaela A, Chiareli, Bruno L, Marques, Gustavo A, de Carvalho, Raysa T V, de Souza, Pedro H G, Santana, Helton C, Santiago, Mauro C X, Pinto, Alexander, Birbrair, Ricardo C, Parreira, Henning, Ulrich, and Rodrigo R, Resende

Subjects
Adult, Neurons, Mammals, Neural Stem Cells, Neurogenesis, Lateral Ventricles, Infant, Newborn, Animals, Humans, Neuroglia
Abstract

Neurogenesis is a biological process characterized by new neurons formation from stem cells. For decades, it was believed that neurons only multiplied during development and in the postnatal period but the discovery of neural stem cells (NSCs) in mature brain promoted a revolution in neuroscience field. In mammals, neurogenesis consists of migration, differentiation, maturation, as well as functional integration of newborn cells into the pre-existing neuronal circuit. Actually, NSC density drops significantly after the first stages of development, however in specific places in the brain, called neurogenic niches, some of these cells retain their ability to generate new neurons and glial cells in adulthood. The subgranular (SGZ), and the subventricular zones (SVZ) are examples of regions where the neurogenesis process occurs in the mature brain. There, the potential of NSCs to produce new neurons has been explored by new advanced methodologies and in neuroscience for the treatment of brain damage and/or degeneration. Based on that, this review highlights endogenous factors and drugs capable of stimulating neurogenesis, as well as the perspectives for the use of NSCs for neurological and neurodegenerative diseases.

Published
2022

41. Quantificação de fatores de crescimento na pele de equinos tratada com plasma rico em plaquetas

Author

Maria V. de Souza, José de O. Pinto, Marcela M. da Costa, Eliziária C. dos Santos, Silvana L.R. Garcia, and Leandro L. de Oliveira

Subjects
Cavalos, concentrado rico em plaquetas, dermatopatia, efeito sistêmico, ELISA, Veterinary medicine, SF600-1100
Abstract

O plasma rico em plaquetas (PRP) é um produto derivado da centrifugação do sangue total, sendo rico em fatores bioativos, como os de crescimento. Apesar da ampla utilização em processos cicatriciais, há controvérsia sobre a eficácia da terapia na cicatrização cutânea. O objetivo desse estudo foi quantificar e comparar a concentração dos fatores TGF-β1 e PDGF-BB no PRP, plasma sanguíneo e pele, durante diferentes fases do processo de cicatrização da pele tratada ou não com PRP. Foram utilizados sete equinos machos castrados, mestiços, hígidos, com idade entre 16 e 17 (16,14±0,63) anos. Três lesões em formato quadrangular (6,25cm²) foram produzidas cirurgicamente nas regiões glúteas direita e esquerda de todos os animais. Doze horas após indução das feridas, 0,5mL do PRP foi administrado em cada uma das quatro extremidades das feridas de uma das regiões glúteas (Grupo tratado = GT), escolhida aleatoriamente. A região contralateral foi utilizada como controle (GC). As feridas foram submetidas à limpeza diária com água Milli Q, e amostras foram obtidas mediante biópsias realizadas com Punch de 6mm. Foram obtidas seis biópsias de pele, sendo a primeira realizada logo após a produção da ferida (T0), e as demais com 1 (T1) 2 (T2) 7 (T3) e 14 (T4) dias após a indução da lesão. A sexta biópsia (T5) foi obtida após completo fechamento da pele, que ocorreu aproximadamente aos 37 dias (36,85±7,45, GC; 38,85±6,46, GT). Também foram obtidas amostras de sangue com EDTA em todos os tempos mencionados. A quantificação dos fatores de crescimento TGF-β1 e PDGF-BB na pele, PRP e plasma sanguíneo foi realizada pela técnica ELISA. Os dados foram analisados estatisticamente pelo teste t, correlação de Pearson e regressão, utilizando nível de significância de 5%. Não houve diferença entre os grupos, nos valores dos dois fatores de crescimento mensurados na pele, nos diferentes tempos. Também não houve correlação entre a quantidade dos fatores de crescimento presentes na pele e no plasma. Por outro lado, correlação positiva foi observada entre PRP e pele no grupo tratado, para os fatores de crescimento TGF-β1 (r=0,31) e PDGF-BB (r=0,38), bem como entre ambos os fatores de crescimento presentes no PRP (r=0,81). Considerando as concentrações dos fatores de crescimento no T0, os maiores valores cutâneos (p

Published
2014
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42. Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications

Author

Anna C. Cunha, Vitor F. Ferreira, Luana da S. M. Forezi, Adriane A P Amaral, Carolina G. S. Lima, Maria Cecília B. V. de Souza, Patricia G. Ferreira, and Fernando de C. da Silva

Subjects
Cycloaddition Reaction, 010405 organic chemistry, General Chemical Engineering, Structural diversity, General Chemistry, Triazoles, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Materials Chemistry, Diazo
Abstract

The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is present in a large number of biologically active molecules, including several drugs currently in the market. Due to their vast applications, a wide variety of methods are described for their preparation, such as the 1,3-dipolar cycloaddition and processes involving diazo compounds and diazo transfer reactions. Considering the significant number of contributions from our research group to this chemistry in recent decades, in this account we discuss both the development of new methods for the synthesis of 1,2,3-triazoles and the preparation of new triazole-functionalized biologically active molecules using classical approaches.

Published
2021

43. Molecular Forces Governing the Biological Function of Per-Arnt-Sim-B (PAS-B) Domains: A Comparative Computational Study

Author

Piotr Zaborniak, Ruidi Zhu, Sylvia Reznikov, Matthew Kondal, João V de Souza, and Agnieszka K. Bronowska

Subjects
D. Suzukii, 0301 basic medicine, Aryl hydrocarbon receptor nuclear translocator, Computational biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, cysteinome, medicine, Transcriptional regulation, HIF1α, Receptor, Drosophila suzukii, Transcription factor, General Environmental Science, Mutation, biology, aryl hydrocarbon receptor, Chemistry, molecular dynamics simulations, Aryl hydrocarbon receptor, biology.organism_classification, Small molecule, 030104 developmental biology, Per-Arnt-Sim, biology.protein, General Earth and Planetary Sciences, NCOA1, HIF2α, 030217 neurology & neurosurgery
Abstract

Per-Arnt-Sim (PAS) domains are evolutionarily-conserved regions found in proteins in all living systems, involved in transcriptional regulation and the response to hypoxic and xenobiotic stress. Despite having low primary sequence similarity, they show an impressively high structural conservation. Nonetheless, understanding the underlying mechanisms that drive the biological function of the PAS domains remains elusive. In this work, we used molecular dynamics simulations and bioinformatics tools in order the investigate the molecular characteristics that govern the intrinsic dynamics of five PAS-B domains (human AhR receptor, NCOA1, HIF1α, and HIF2α transcription factors, and Drosophila Suzukii (D. Suzukii) juvenile hormone receptor JHR). First, we investigated the effects of different length of N and C terminal regions of the AhR PAS-B domain, showing that truncation of those segments directly affects structural stability and aggregation propensity of the domain. Secondly, using the recently annotated PAS-B located in the methoprene-tolerant protein/juvenile hormone receptor (JHR) from D. Suzukii, we have shown that the mutation of the highly conserved “gatekeeper” tyrosine to phenylalanine (Y322F) does not affect the stability of the domain. Finally, we investigated possible redox-regulation of the AhR PAS-B domain by focusing on the cysteinome residues within PAS-B domains. The cysteines in AhR PAS-B are directly regulating the dynamics of the small molecule ligand-gating loop (residues 305 to 326). In conclusion, we comprehensibly described several molecular features governing the behaviour of PAS-B domains in solution, which may lead to a better understanding of the forces driving their biological functions.

Published
2021

44. Removal of fungal ball from the jaws by lefort i osteotomy: Difficulty in diagnosing patients with chronic sinusitis

Author

V. de Souza, C. Ricken, A. Pavan, Andressa Bolognesi Bachesk, and R. Pierri

Subjects
medicine.medical_specialty, Oral Medicine and Pathology, Maxillary sinus, business.industry, medicine.medical_treatment, Orthognathic surgery, Chronic sinusitis, Case Report, Aspergillosis, medicine.disease, Osteotomy, Surgery, Lesion, medicine.anatomical_structure, Paranasal sinuses, medicine, Clinical case, medicine.symptom, business, General Dentistry, UNESCO:CIENCIAS MÉDICAS
Abstract

Aspergillosis, aka fungal ball (FB), is classified as a type of non-invasive fungal rhinosinusitis, which usually occurs unilaterally in the maxillary sinus of an immunocompromised patient. Its diagnosis is complex and depends on the association between clinical, imaging, and histopathological exams. There are many treatments for fungal infections of the paranasal sinuses, so early diagnosis is extremely important to determine the appropriate treatment. This paper reports an unusual clinical case of aspergillosis present bilaterally inside the maxillary sinuses of a healthy patient, associated with mucous retention cysts, whose imaging exams and transnasal endoscopy were not sufficient to precisely identify the lesion. Its diagnosis and definitive treatment were obtained only after orthognathic surgery and integration between a multidisciplinary team. Key words:Aspergillosis, communicable diseases, fungal ball, infectious disease, orthognathic surgery.

Published
2021

45. An overview of the natural force density method and its implementation on an efficient parametric computational framework

Author

Ruy Marcelo de Oliveira Pauletti and Márcio S. V. de Souza

Subjects
Computer science, 0211 other engineering and technologies, Computational Mechanics, Aerospace Engineering, 020101 civil engineering, 02 engineering and technology, minimal surfaces, Natural (archaeology), 0201 civil engineering, tensile structures, Architecture, Parametric modelling, parametric modelling, Applied mathematics, 021104 architecture, CAE, Safety, Risk, Reliability and Quality, form-finding, Civil and Structural Engineering, Parametric statistics, force density, natural force density, Minimal surface, Force density, Mechanics of engineering. Applied mechanics, TA349-359, Building and Construction, taut structures, Mechanics of Materials, grasshopper
Abstract

The new paradigms of parametric modelling have been proving promising on the advance of systems for analysis and design of taut (or tensile) structures. With this premise, the presented work consist on the development with a form-finding tool for Computer Aided Design(CAE) and Computer Aided Engineering (CAE) integration using VPL (Visual Programming Language), in the context of parametric modelling. The methods used in the implementation are the Force Density Method (FDM) and the Natural Force Density Method (NFDM), taking advantage of the linear solution approach provided, suitable for fast form-finding computational procedures. The program is implemented as a Grasshopper plug-in and it is named BATS (Basic Analysis of Taut Structures), which enables parametric definition of boundary conditions for the form-finding. The program structure and benchmarks with other available Grasshopper plug-ins for taut structures form-finding are presented, showing considerably superior performance using BATS.

Published
2021

46. Covid‐19 Pandemic, Social Mitigation and Taxation: The Open Veins of Inequality in Latin America

Author

Fernanda Cimini, Nayara Abreu Julião, A. V. De Souza, and N. Cabral

Subjects
Latin Americans, Inequality, Latin American studies, media_common.quotation_subject, Geography, Planning and Development, Development, Politics, Political science, Political economy, Progressive tax, Pandemic, Narrative, Socioeconomic status, media_common
Abstract

The pandemic of Covid-19 has exposed the veins of inequality in Latin America With a socioeconomic disaster looming, social emergency policies seemed inevitable Yet while governments argue over the continuity of such policies and whether the fiscal rules in place should be respected, no sustainable response has come out This essay problematises whether the pandemic could represent a critical juncture to forge ahead with political narratives that highlight tax exemptions and privileges enjoyed by the rich We analyse the mitigation measures adopted by Argentina, Brazil, Chile and Uruguay and their repercussions on the debate surrounding progressive tax reforms to fund social schemes © 2020 Society for Latin American Studies

Published
2020

47. Bacterial Enoyl-Reductases: The Ever-Growing List of Fabs, Their Mechanisms and Inhibition

Author

Fernanda S. M. Hopf, Candida D. Roth, Eduardo V. de Souza, Luiza Galina, Alexia M. Czeczot, Pablo Machado, Luiz A. Basso, and Cristiano V. Bizarro

Subjects
Microbiology (medical), Microbiology
Abstract

Enoyl-ACP reductases (ENRs) are enzymes that catalyze the last step of the elongation cycle during fatty acid synthesis. In recent years, new bacterial ENR types were discovered, some of them with structures and mechanisms that differ from the canonical bacterial FabI enzymes. Here, we briefly review the diversity of structural and catalytic properties of the canonical FabI and the new FabK, FabV, FabL, and novel ENRs identified in a soil metagenome study. We also highlight recent efforts to use the newly discovered Fabs as targets for drug development and consider the complex evolutionary history of this diverse set of bacterial ENRs.

Published
2022

49. Causal attribution among women with breast cancer

Author

Ana Carolina W. B. Peuker, Maria Júlia Armiliato, Luisa V. de Souza, and Elisa K. de Castro

Subjects
Breast neoplasm, Illness perception, Beliefs, Psychology, BF1-990
Abstract

Abstract Causal attribution among women with breast cancer was studied. The study included 157 women outpatients with breast cancer. A form for sociodemographic and clinical data and the Revised Illness Perception Questionnaire (IPQ-R) were used. The results showed that women attributed breast cancer primarily to psychological causes, which does not correspond to known multifactorial causes validated by the scientific community. Providing high quality, patient-centered care requires sensitivity to breast cancer women’s beliefs about the causes of their cancer and awareness of how it can influence patient’s health behaviors after diagnosis. If women with breast cancer attribute the illness to modifiable factors then they can keep a healthy lifestyle, improving their recovery and decrease the probability of cancer recurrence after diagnosis.

Published
2016
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50. Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

Author

João V de Souza, Gavin D. Richardson, Fehmi M Benli, Danlin Liu, Ioakim Spyridopoulos, Agnieszka K. Bronowska, and Catherine Park

Subjects
Inflammation, Aging, Inflammasomes, Drug discovery, business.industry, Druggability, Context (language use), Inflammasome, General Medicine, Proinflammatory cytokine, Nicotinic agonist, Drug development, Cardiovascular Diseases, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Molecular Targeted Therapy, Receptor, business, Neuroscience, medicine.drug
Abstract

In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

Published
2020

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