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1. Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment

Author

L. Fernandez Pellon, E. Macias Fernandez, Manuel J Rial, E. Morchon Miguel, V. Vilella Tomás, P. Marin Martinez, V. De Luque Piñana, V. García Paz, M. Morales Villarejo, J. Ruiz Hornillos, J. Herrero Jarque, J. Florido Lopez, J. Beitia Mazuecos, M. Rojas Vilchez, J. Medina Gallardo, J. Valldeperas Combas, A. Pallarés Sanmartín, I. García Núñez, J. Castro Landin, R. Diaz Campos, G. Gala Ortiz, M. Mena Rodriguez, O. Villarreal Balza De Vallejo, Vicente Plaza, E. Pinto Nogues, A. Suárez Rodríguez, P. Sánchez López, S. Díaz Angulo, F. Sola Martinez, M. Moscardó Orenes, M. Alvariño Martin, R. Tejedor Romera, J. Orta Cuevas, Z. Vasquez Gambasica, B. García Figueroa, A. Letran Camacho, M. Modesto Alapont, M. Cervera Del Pino, P. Benito Martinez, S. Varela Losada, F. Carballada Gonzalez, Irina Bobolea, M. Díaz Palacios, Y. Anta Mejias, D. González De Olano, J. Martos Velasco, P. Prieto Montaño, A. Sanchez Alonso, M. Martínez Ceres, J. Donado Uña, Ò. Sotorra Elias, B. Alcázar Navarrete, A. Arnedillo Muñoz, J. Alcazar Ramirez, J. Jiménez López, M. Alvarez Puebla, M. Antón Girones, J. Compaired Villa, P. Mata Calderon, M. Escribano Rodriguez, C. Morales García, I. Molero Sancho, M. De Las Marinas Alvarez, T. Bazus Gonzalez, M. Soria Esojo, A. Vega Castro, A. Moreno Fernandez, G. Jorro Martínez, E. Ortega Sáenz De Tejada, A. Regueiro Moreira, M. Garcimartin Galicia, A. Alonso Gomez, R. Rodriguez Martinez, J. Liñana Santafé, I. Ansotegui Zubeldia, R. Lama Martinez, A. Saura Vinuesa, N. Segura Arazuri, M. Torrecillas Toro, M. Climent Gregori, M. Herrerias Peña, T. Peña Miguel, C. Vila Albelda, C. Diaz Donado, M. Hernandez, A. Losada Peña, M. Gandolfo Cano, J. Montoro Lacomba, J. Quiralte Enriquez, R. Rodríguez Pacheco, M. Arroyo Cozar, P. Rubinstein Aguñin, M. Blanco Aparicio, F. Alvarez Gutierrez, C. Merinas Lopez, R. Mayorgas Costoya, M. Franco Campos, J. Garcia De Pedro, V. Moreno Garcia, J. De Frutos Arribas, J. Alvarez Fernandez, A. Robles Iniesta, M. Do Muíño Joga, A. Bueso Fernandez, P. Serrano Dominguez, M. Jimenez Lara, P. Losada Llorente, C. Colás Sanz, I. Raducan, B. Requejo Mañana, M. Mota Godoy, M. Martos Calahorro, F. Ortiz Portal, J. Zapata Yébenes, F. Nicolau Pastrie, C. Rabade Castedo, M. Salvador Segarra, F. Callejas González, M. Chacon Patiño, G. González Álvarez, J. Olaguibel Rivera, P. Gonzalez Delgado, B. Orosa Bertol, E. De Santiago Delgado, J. Cumplido Bonny, R. Nuñez Orjales, Antonio Fernandez-Sanchez, B. Añíbarro Bausela, D. Ferrer Pargada, S. Niño Bernal, A. Cobas Paz, B. Huertas Barbudo, J. Ciruelos Ayuso, M. Lara Jiménez, D. Gutierrez Fernandez, G. Castaño De Las Pozas, Y. García Villamuza, F. Sánchez-Toril López, E. Naval Sendra, C. Andreu Balaguer, M. Rico Diaz, L. Navarro Seisdedos, D. El-Qutob López, J. Ruiz Cubillan, Miguel Ibáñez Rodríguez, L. Fontan Garcia-Boente, M. Rivera Ortun, A. Padilla Galo, M. Muñoz Pamplona, I. Perez Sampedro, F. Garcia Gonzalez, E. Gómez Nieves, S. Aparicio Español, Astrid Crespo, A. Lloris Bayo, R. Lleonart Bellfill, E. Burches Baixauli, R. Andujar Espinosa, I. Picans, F. Linde De Luna, A. Tabar Purroy, L. Valverde Vazquez, R. Blanco Gonzalez, M. Ballester Canelles, P. Barranco Sanz, F. Ruano Perez, A. Romero Ortiz, S. Jimenez Timon, G. De Luiz Martínez, C. Baeza Martinez, G. Bernaola Hortigüela, J. Chamorro Mohedad, M. Garcés Sotillos, R. Moreno Borque, M. Moro, I. Ali García, S. Lizarza Mendizabal, J. Almagro Lopez, C. Perez Carral, J. Cegoñino De Sus, M. Reche Frutos, R. González Perez, M. Domínguez Fuentes, L. Cassini Gomez De Cadiz, A. Feliu Vila, M. Dordal Culla, M. Corbacho Abelaira, Y. Puente Crespo, D. Romero Ribate, J. Rozadilla Sacanell, J. Lopez Caballero, A. Velez Ruiz De Lobera, A. Montoro De Francisco, M. Ramirez Prieto, N. Marina Malanda, J. Juanola Pla, M. Millan Gonzalez, N. Subira Farre, P. Cordero Rodriguez, F. Gonzalez Barcala, S. Herrera Lara, M. Peña Arellano, J. Igea Aznar, R. Alvarez Sintes, E. Martinez Moragon, J. Greses Giner, M. Martínez Riaza, G. Mediero Carrasco, P. Catalán Serra, M. Rodriguez Hernandez, S. Porcel Carreño, Joaquín Sastre, A. Ruiz San Francisco, R. Bernabeu Mora, M. Alwakil Olbah, H. Izaguirre Flores, J. Subiza Garrido-Lestache, B. Labeguerie Arenaza, B. Presedo Garazo, S. Cimbollek, A. Fuster Gomila, G. Minguez Martin, M. Martín Pérez, S. Garrido Fernández, F. Iglesias Rio, A. Veres Racamonde, B. Rodriguez Jimenez, F. Muñoz Bellido, A. Moral De Gregorio, A. López Viña, J. Marin Torrado, I. Flores Martín, M. Avilés Inglés, A. Lahuerta Castro, and P. Galindo Bonilla

Subjects
Adult, Male, Spirometry, medicine.medical_specialty, Vital capacity, Anxiety, Hospital Anxiety and Depression Scale, Severity of Illness Index, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Forced Expiratory Volume, Internal medicine, Health care, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, Depression (differential diagnoses), Asthma, medicine.diagnostic_test, Depression, business.industry, Middle Aged, medicine.disease, respiratory tract diseases, 030228 respiratory system, Female, medicine.symptom, business
Abstract

Background It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health care resources, and poor asthma control. Objective To examine the association of asthma diagnosis with symptoms of depression/anxiety and asthma control not only at baseline but also over a 6-month period of specialist supervision. Methods We enrolled 3182 patients with moderate to severe asthma. All were evaluated with spirometry, the Asthma Control Test, and the Hospital Anxiety and Depression Scale at baseline and at 6 months. Treatments were decided by specialists according to published guidelines. Results At baseline, 24.2% and 12% of the patients were diagnosed with anxiety and depression, respectively, according to the Hospital Anxiety and Depression Scale. After 6 months, anxiety and depression improved, affecting 15.3% and 8.1% of patients, respectively (P Conclusion Under standardized asthma care and after a specific visit with the specialist, patients present significant improvement in these psychological disorders and exhibit better asthma control and functional parameters.

Published
2018

2. Vitamin K Antagonists After 6 Months of Low-Molecular-Weight Heparin in Cancer Patients with Venous Thromboembolism

Author

Chatree Chai-Adisaksopha, Alfonso Iorio, Mark A. Crowther, Javier de Miguel, Estuardo Salgado, Marija Zdraveska, Carmen Fernández-Capitán, José Antonio Nieto, Giovanni Barillari, Laurent Bertoletti, Manuel Monreal, M.A. Aibar, J.I. Arcelus, A. Ballaz, R. Barba, M. Barrón, B. Barrón-Andrés, J. Bascuñana, A. Blanco-Molina, T. Bueso, B. Calvo, G. Cañada, I. Cañas, I. Casado, A. Culla, J. de Miguel, J. del Toro, J.A. Díaz-Peromingo, C. Falgá, C. Fernández-Capitán, C. Font, L. Font, P. Gallego, F. García-Bragado, V. Gómez, J. González, E. Grau, M. Guil, L. Guirado, J. Gutiérrez, G. Hernández, L. Hernández-Blasco, V. Isern, L. Jara-Palomares, M.J. Jaras, D. Jiménez, B. Lacruz, R. Lecumberri, J.L. Lobo, L. López-Jiménez, R. López-Reyes, J.B. López-Sáez, M.A. Lorente, A. Lorenzo, O. Madridano, A. Maestre, I. Manrique-Abos, P.J. Marchena, J.M. Martín-Antorán, F. Martín-Martos, M. Monreal, M.V. Morales, R. Morillo, D. Nauffal, J.A. Nieto, S. Nieto, M.J. Núñez, M. Odriozola, S. Otalora, R. Otero, B. Pagán, J.M. Pedrajas, C. Pérez, M.L. Peris, I. Pons, J.A. Porras, L. Ramirez, A. Riera, A. Rivas, C. Rodríguez, M.A. Rodríguez-Dávila, V. Rosa, N. Ruiz-Giménez, A. Sampériz, R. Sánchez, M.C. Sala, J.C. Sahuquillo, O. Sanz, S. Soler, I. Suárez-González, J.M. Suriñach, G. Tiberio, C. Tolosa, J. Trujillo-Santos, F. Uresandi, B. Valero, R. Valle, J. Vela, M.P. Vicente, G. Vidal, V. Vilella-Tomás, J. Villalta, P.C. Malfante, T. Vanassche, P. Verhamme, P. Wells, J. Hirmerova, R. Malý, T. Tomko, G. Celis, E. Salgado, G.T. Sánchez, L. Bertoletti, A. Bura-Riviere, D. Farge-Bancel, A. Hij, I. Mahé, A. Merah, I. Quere, M. Papadakis, A. Braester, B. Brenner, I. Tzoran, A. Apollonio, G. Barillari, A. Bertone, F. Bilora, E. Bucherini, G. Candelero, M. Ciammaichella, P. Di Micco, P. Ferrazzi, E. Grandone, G. Lessiani, C. Lodigiani, D. Mastroiacovo, F. Pace, R. Pesavento, M. Pinelli, P. Prandoni, M. Rosa, L. Rota, E. Tiraferri, D. Tonello, A. Tufano, U. Venturelli, A. Visonà, B. Zalunardo, E. Drucka, D. Kigitovica, A. Skride, M.S. Sousa, M. Bosevski, M. Zdraveska, H. Bounameaux, L. Mazzolai, and J.C. Serrano

Subjects
Male, medicine.medical_specialty, Vitamin K, medicine.drug_class, Deep vein, Low molecular weight heparin, Anticoagulants, Cancer, Low-molecular-weight heparin, Thromboembolism, Warfarin, 030204 cardiovascular system & hematology, Recurrent deep vein thrombosis, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Neoplasms, medicine, Humans, Registries, Propensity Score, Aged, Retrospective Studies, business.industry, Retrospective cohort study, General Medicine, Venous Thromboembolism, Heparin, Low-Molecular-Weight, medicine.disease, Thrombosis, Pulmonary embolism, Surgery, Venous thrombosis, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, business, medicine.drug
Abstract

BACKGROUND: Low-molecular-weight heparin (LMWH) is the treatment of choice in cancer patients with venous thromboembolism. However, data on continuing LMWH treatment beyond 6 months remain scanty. METHODS: We used the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry to compare the rate of venous thromboembolism recurrences and major bleeding appearing beyond the first 6 months of anticoagulant therapy in cancer patients with venous thromboembolism, according to therapy with LMWH or vitamin K antagonists (VKA). We performed a propensity score-matched cohort study. RESULTS: After propensity matching, 482 cancer patients continued to receive LMWH and 482 switched to VKA. During the course of anticoagulant therapy (mean 275.5 days), 57 patients developed venous thrombosis recurrences (recurrent pulmonary embolism 26, recurrent deep vein thrombosis 29, both 2), 28 had major bleeding, 38 had nonmajor bleeding, and 129 died. No patient died of recurrent venous thrombosis, and 5 patients died of bleeding (2 were on LMWH, 3 on VKA). Patients who continued with LMWH had a similar rate of deep vein thrombosis recurrences (relative risk [RR] 1.41; 95% confidence interval [CI], 0.68-2.93), pulmonary embolism recurrences (RR 0.73; 95% CI, 0.34-1.58), major bleeding (RR 0.96; 95% CI, 0.51-1.79), or nonmajor bleeding (RR 1.15; 95% CI, 0.55-2.40), compared with those who switched to VKA, but a higher mortality rate (RR 1.58; 95% CI, 1.13-2.20). CONCLUSIONS: In cancer patients with venous thromboembolism who completed 6 months of LMWH therapy, switching to VKA was associated with a similar risk of venous thrombosis recurrences or bleeding when compared with patients who continued LMWH. (C) 2018 Elsevier Inc. All rights reserved.

Published
2017

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