5 results on '"V. Tamborrino"'
Search Results
2. Combination therapy with ribavirin and alpha interferon for the treatment of chronic hepatitis C refractory to interferon
- Author
-
Emilio Jirillo, Vito Giannuzzi, R. Cuppone, O. G. Manghisi, Luigi Amati, L. Caradonna, Raffaele Cozzolongo, and V. Tamborrino
- Subjects
medicine.medical_specialty ,Hepatology ,Combination therapy ,business.industry ,Ribavirin ,Hepatitis C virus ,Gastroenterology ,Alpha interferon ,Hepatitis C ,medicine.disease ,medicine.disease_cause ,chemistry.chemical_compound ,chemistry ,Interferon ,Internal medicine ,Immunology ,medicine ,Pharmacology (medical) ,Adverse effect ,business ,Interferon alfa ,medicine.drug - Abstract
Background: Up to 80% of hepatitis C patients are refractory to treatment with interferon-α. These patients are not likely to benefit from higher dosages or longer duration of interferon alone. The addition of ribavirin has been shown to improve the response rate in patients resistant to a previous course of interferon-α alone. Aim: To evaluate whether a sustained hepatitis C virus (HCV) RNA response could be obtained with combination therapy of interferon-α and ribavirin in patients who did not respond to or relapsed after a standard interferon-α treatment. Methods: A total of 73 patients, 59 non-responders and 14 relapsers after interferon-α alone, were treated with a combination of ribavirin (1000–1200 mg/day) and interferon-α (3 MU three times a week) for 24 weeks. Alanine aminotransferase levels and HCV RNA were checked for 24 weeks after completion of therapy. Results: At the end of the combination therapy, 36 patients (49%) showed alanine aminotransferase normalization and in 20 patients (27%), HCV RNA was undetectable in serum. At the end of the 24 weeks follow-up period, only 12 patients (16%) had a sustained response with serum negativity of HCV RNA. This response was significantly higher in relapsers than in non-responders: five (36%) vs. seven (12%) patients (P=0.03), respectively. Adverse effects were restricted to flu-like symptoms and moderate haemolytic anaemia. Conclusions: Combination of interferon-α and ribavirin is quite limited, both in scope and efficacy, in HCV patients who had a non-response to monotherapy with interferon. Better results may be expected in relapsers, but larger studies are necessary.
- Published
- 2001
3. Combination therapy with ribavirin and alpha interferon for the treatment of chronic hepatitis C refractory to interferon
- Author
-
R, Cozzolongo, R, Cuppone, V, Giannuzzi, L, Amati, L, Caradonna, V, Tamborrino, E, Jirillo, and O G, Manghisi
- Subjects
Adult ,Male ,Ribavirin ,Humans ,Interferon-alpha ,RNA, Viral ,Drug Therapy, Combination ,Female ,Hepatitis C, Chronic ,Middle Aged ,Antiviral Agents ,Aged - Abstract
Up to 80% of hepatitis C patients are refractory to treatment with interferon-alpha. These patients are not likely to benefit from higher dosages or longer duration of interferon alone. The addition of ribavirin has been shown to improve the response rate in patients resistant to a previous course of interferon-alpha alone.To evaluate whether a sustained hepatitis C virus (HCV) RNA response could be obtained with combination therapy of interferon-alpha and ribavirin in patients who did not respond to or relapsed after a standard interferon-alpha treatment.A total of 73 patients, 59 non-responders and 14 relapsers after interferon-alpha alone, were treated with a combination of ribavirin (1000-1200 mg/day) and interferon-alpha (3 MU three times a week) for 24 weeks. Alanine aminotransferase levels and HCV RNA were checked for 24 weeks after completion of therapy.At the end of the combination therapy, 36 patients (49%) showed alanine aminotransferase normalization and in 20 patients (27%), HCV RNA was undetectable in serum. At the end of the 24 weeks follow-up period, only 12 patients (16%) had a sustained response with serum negativity of HCV RNA. This response was significantly higher in relapsers than in non-responders: five (36%) vs. seven (12%) patients (P=0.03), respectively. Adverse effects were restricted to flu-like symptoms and moderate haemolytic anaemia.Combination of interferon-alpha and ribavirin is quite limited, both in scope and efficacy, in HCV patients who had a non-response to monotherapy with interferon. Better results may be expected in relapsers, but larger studies are necessary.
- Published
- 2001
4. An early, customized low-glycemic-index diet prevents adverse pregnancy outcomes in overweight/obese women.
- Author
-
Petrella E, Tamborrino V, Di Cerbo L, Neri I, and Facchinetti F
- Subjects
- Adult, Body Mass Index, Case-Control Studies, Diabetes, Gestational epidemiology, Exercise, Female, Follow-Up Studies, Glycemic Index, Humans, Hypertension, Pregnancy-Induced epidemiology, Infant, Newborn, Obesity complications, Obesity epidemiology, Overweight complications, Overweight epidemiology, Pregnancy, Pregnancy Complications epidemiology, Premature Birth epidemiology, Retrospective Studies, Weight Gain, Diet, Obesity therapy, Overweight therapy, Pregnancy Outcome
- Abstract
Background: To determine whether the prescription and follow-up of a behavioral program (customized nutritional advices and a constant physical activity) influences the occurrence of unfavorable maternal/neonatal outcomes among overweight/obese women., Methods: A case-control study (1:3) included single pregnant women with Body Mass Index (BMI) ≥25 kg/m2, enrolled at 1st trimester. Cases (N.=95) were prescribed (by both the dietitian and gynecologist) a low-glycemic-index diet with an average intake of 1700/1800 kcal/day plus 30 minutes of walking at least 3 times/week (with four follow-up visits until delivery). Controls (N.=275) received a nutritional booklet about a healthy lifestyle, then attended their scheduled visits until delivery by the obstetricians in charge., Results: Gestational weight gain was similar between groups, despite obese women were higher in cases (67.4%) than in controls (54.5%, P=0.029). The occurrence of gestational diabetes mellitus (GDM) was lower in cases (21.5%) than in controls (32.7%; P=0.041). Such reduction remained related with the group of intervention (P=0.004) after correcting for confounders (BMI≥30 kg/m2, a family history of diabetes, age ≥35 and ethnicity). A higher number of controls developed pregnancy induced hypertension (PIH) (11.6% vs. 1.1% in cases, P<0.001). Preterm birth (PTB) occurred in one case and in 28 controls (10.2%; P=0.004). In half of them, PTB was spontaneous while medically indicated for intrauterine growth restriction, hemorrhage, PIH, GDM/macrosomia, Rh isoimmunization in the remnant., Conclusions: An early behavioral intervention among overweight/obese pregnant women reduces unfavorable pregnancy outcomes.
- Published
- 2018
- Full Text
- View/download PDF
5. Combination therapy with ribavirin and alpha interferon for the treatment of chronic hepatitis C refractory to interferon.
- Author
-
Cozzolongo R, Cuppone R, Giannuzzi V, Amati L, Caradonna L, Tamborrino V, Jirillo E, and Manghisi OG
- Subjects
- Adult, Aged, Drug Therapy, Combination, Female, Hepatitis C, Chronic virology, Humans, Interferon-alpha adverse effects, Male, Middle Aged, RNA, Viral blood, Ribavirin adverse effects, Antiviral Agents administration & dosage, Hepatitis C, Chronic drug therapy, Interferon-alpha administration & dosage, Ribavirin administration & dosage
- Abstract
Background: Up to 80% of hepatitis C patients are refractory to treatment with interferon-alpha. These patients are not likely to benefit from higher dosages or longer duration of interferon alone. The addition of ribavirin has been shown to improve the response rate in patients resistant to a previous course of interferon-alpha alone., Aim: To evaluate whether a sustained hepatitis C virus (HCV) RNA response could be obtained with combination therapy of interferon-alpha and ribavirin in patients who did not respond to or relapsed after a standard interferon-alpha treatment., Methods: A total of 73 patients, 59 non-responders and 14 relapsers after interferon-alpha alone, were treated with a combination of ribavirin (1000-1200 mg/day) and interferon-alpha (3 MU three times a week) for 24 weeks. Alanine aminotransferase levels and HCV RNA were checked for 24 weeks after completion of therapy., Results: At the end of the combination therapy, 36 patients (49%) showed alanine aminotransferase normalization and in 20 patients (27%), HCV RNA was undetectable in serum. At the end of the 24 weeks follow-up period, only 12 patients (16%) had a sustained response with serum negativity of HCV RNA. This response was significantly higher in relapsers than in non-responders: five (36%) vs. seven (12%) patients (P=0.03), respectively. Adverse effects were restricted to flu-like symptoms and moderate haemolytic anaemia., Conclusions: Combination of interferon-alpha and ribavirin is quite limited, both in scope and efficacy, in HCV patients who had a non-response to monotherapy with interferon. Better results may be expected in relapsers, but larger studies are necessary.
- Published
- 2001
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.