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10. Impact of diabetes on the management and outcomes in atrial fibrillation:an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

Author

Wern Yew Ding, Agnieszka Kotalczyk, Giuseppe Boriani, Francisco Marin, Carina Blomström-Lundqvist, Tatjana S. Potpara, Laurent Fauchier, Gregory.Y.H. Lip, G. Boriani, G.Y.H. Lip, L. Tavazzi, A.P. Maggioni, G.-A. Dan, T. Potpara, M. Nabauer, F. Marin, Z. Kalarus, A. Goda, G. Mairesse, T. Shalganov, L. Antoniades, M. Taborsky, S. Riahi, P. Muda, I. García Bolao, O. Piot, K. Etsadashvili, E. Simantirakis, M. Haim, A. Azhari, J. Najafian, M. Santini, E. Mirrakhimov, K.A. Kulzida, A. Erglis, L. Poposka, M. Burg, H. Crijns, Ö. Erküner, D. Atar, R. Lenarczyk, M. Martins Oliveira, D. Shah, E. Serdechnaya, E. Diker, D. Lane, E. Zëra, U. Ekmekçiu, V. Paparisto, M. Tase, H. Gjergo, J. Dragoti, M. Ciutea, N. Ahadi, Z. el Husseini, M. Raepers, J. Leroy, P. Haushan, A. Jourdan, C. Lepiece, L. Desteghe, J. Vijgen, P. Koopman, G. Van Genechten, H. Heidbuchel, T. Boussy, M. De Coninck, H. Van Eeckhoutte, N. Bouckaert, A. Friart, J. Boreux, C. Arend, P. Evrard, L. Stefan, E. Hoffer, J. Herzet, M. Massoz, C. Celentano, M. Sprynger, L. Pierard, P. Melon, B. Van Hauwaert, C. Kuppens, D. Faes, D. Van Lier, A. Van Dorpe, A. Gerardy, O. Deceuninck, O. Xhaet, F. Dormal, E. Ballant, D. Blommaert, D. Yakova, M. Hristov, T. Yncheva, N. Stancheva, S. Tisheva, M. Tokmakova, F. Nikolov, D. Gencheva, B. Kunev, M. Stoyanov, D. Marchov, V. Gelev, V. Traykov, A. Kisheva, H. Tsvyatkov, R. Shtereva, S. Bakalska-Georgieva, S. Slavcheva, Y. Yotov, M. Kubíčková, A. Marni Joensen, A. Gammelmark, L. Hvilsted Rasmussen, P. Dinesen, S. Krogh Venø, B. Sorensen, A. Korsgaard, K. Andersen, C. Fragtrup Hellum, A. Svenningsen, O. Nyvad, P. Wiggers, O. May, A. Aarup, B. Graversen, L. Jensen, M. Andersen, M. Svejgaard, S. Vester, S. Hansen, V. Lynggaard, M. Ciudad, R. Vettus, A. Maestre, S. Castaño, S. Cheggour, J. Poulard, V. Mouquet, S. Leparrée, J. Bouet, J. Taieb, A. Doucy, H. Duquenne, A. Furber, J. Dupuis, J. Rautureau, M. Font, P. Damiano, M. Lacrimini, J. Abalea, S. Boismal, T. Menez, J. Mansourati, G. Range, H. Gorka, C. Laure, C. Vassalière, N. Elbaz, N. Lellouche, K. Djouadi, F. Roubille, D. Dietz, J. Davy, M. Granier, P. Winum, C. Leperchois-Jacquey, H. Kassim, E. Marijon, J. Le Heuzey, J. Fedida, C. Maupain, C. Himbert, E. Gandjbakhch, F. Hidden-Lucet, G. Duthoit, N. Badenco, T. Chastre, X. Waintraub, M. Oudihat, J. Lacoste, C. Stephan, H. Bader, N. Delarche, L. Giry, D. Arnaud, C. Lopez, F. Boury, I. Brunello, M. Lefèvre, R. Mingam, M. Haissaguerre, M. Le Bidan, D. Pavin, V. Le Moal, C. Leclercq, T. Beitar, I. Martel, A. Schmid, N. Sadki, C. Romeyer-Bouchard, A. Da Costa, I. Arnault, M. Boyer, C. Piat, N. Lozance, S. Nastevska, A. Doneva, B. Fortomaroska Milevska, B. Sheshoski, K. Petroska, N. Taneska, N. Bakrecheski, K. Lazarovska, S. Jovevska, V. Ristovski, A. Antovski, E. Lazarova, I. Kotlar, J. Taleski, S. Kedev, N. Zlatanovik, S. Jordanova, T. Bajraktarova Proseva, S. Doncovska, D. Maisuradze, A. Esakia, E. Sagirashvili, K. Lartsuliani, N. Natelashvili, N. Gumberidze, R. Gvenetadze, N. Gotonelia, N. Kuridze, G. Papiashvili, I. Menabde, S. Glöggler, A. Napp, C. Lebherz, H. Romero, K. Schmitz, M. Berger, M. Zink, S. Köster, J. Sachse, E. Vonderhagen, G. Soiron, K. Mischke, R. Reith, M. Schneider, W. Rieker, D. Boscher, A. Taschareck, A. Beer, D. Oster, O. Ritter, J. Adamczewski, S. Walter, A. Frommhold, E. Luckner, J. Richter, M. Schellner, S. Landgraf, S. Bartholome, R. Naumann, J. Schoeler, D. Westermeier, F. William, K. Wilhelm, M. Maerkl, R. Oekinghaus, M. Denart, M. Kriete, U. Tebbe, T. Scheibner, M. Gruber, A. Gerlach, C. Beckendorf, L. Anneken, M. Arnold, S. Lengerer, Z. Bal, C. Uecker, H. Förtsch, S. Fechner, V. Mages, E. Martens, H. Methe, T. Schmidt, B. Schaeffer, B. Hoffmann, J. Moser, K. Heitmann, S. Willems, C. Klaus, I. Lange, M. Durak, E. Esen, F. Mibach, H. Mibach, A. Utech, M. Gabelmann, R. Stumm, V. Ländle, C. Gartner, C. Goerg, N. Kaul, S. Messer, D. Burkhardt, C. Sander, R. Orthen, S. Kaes, A. Baumer, F. Dodos, A. Barth, G. Schaeffer, J. Gaertner, J. Winkler, A. Fahrig, J. Aring, I. Wenzel, S. Steiner, A. Kliesch, E. Kratz, K. Winter, P. Schneider, A. Haag, I. Mutscher, R. Bosch, J. Taggeselle, S. Meixner, A. Schnabel, A. Shamalla, H. Hötz, A. Korinth, C. Rheinert, G. Mehltretter, B. Schön, N. Schön, A. Starflinger, E. Englmann, G. Baytok, T. Laschinger, G. Ritscher, A. Gerth, D. Dechering, L. Eckardt, M. Kuhlmann, N. Proskynitopoulos, J. Brunn, K. Foth, C. Axthelm, H. Hohensee, K. Eberhard, S. Turbanisch, N. Hassler, A. Koestler, G. Stenzel, D. Kschiwan, M. Schwefer, S. Neiner, S. Hettwer, M. Haeussler-Schuchardt, R. Degenhardt, S. Sennhenn, M. Brendel, A. Stoehr, W. Widjaja, S. Loehndorf, A. Logemann, J. Hoskamp, J. Grundt, M. Block, R. Ulrych, A. Reithmeier, V. Panagopoulos, C. Martignani, D. Bernucci, E. Fantecchi, I. Diemberger, M. Ziacchi, M. Biffi, P. Cimaglia, J. Frisoni, I. Giannini, S. Boni, S. Fumagalli, S. Pupo, A. Di Chiara, P. Mirone, F. Pesce, C. Zoccali, V.L. Malavasi, A. Mussagaliyeva, B. Ahyt, Z. Salihova, K. Koshum-Bayeva, A. Kerimkulova, A. Bairamukova, B. Lurina, R. Zuzans, S. Jegere, I. Mintale, K. Kupics, K. Jubele, O. Kalejs, K. Vanhear, M. Cachia, E. Abela, S. Warwicker, T. Tabone, R. Xuereb, D. Asanovic, D. Drakalovic, M. Vukmirovic, N. Pavlovic, L. Music, N. Bulatovic, A. Boskovic, H. Uiterwaal, N. Bijsterveld, J. De Groot, J. Neefs, N. van den Berg, F. Piersma, A. Wilde, V. Hagens, J. Van Es, J. Van Opstal, B. Van Rennes, H. Verheij, W. Breukers, G. Tjeerdsma, R. Nijmeijer, D. Wegink, R. Binnema, S. Said, S. Philippens, W. van Doorn, T. Szili-Torok, R. Bhagwandien, P. Janse, A. Muskens, M. van Eck, R. Gevers, N. van der Ven, A. Duygun, B. Rahel, J. Meeder, A. Vold, C. Holst Hansen, I. Engset, B. Dyduch-Fejklowicz, E. Koba, M. Cichocka, A. Sokal, A. Kubicius, E. Pruchniewicz, A. Kowalik-Sztylc, W. Czapla, I. Mróz, M. Kozlowski, T. Pawlowski, M. Tendera, A. Winiarska-Filipek, A. Fidyk, A. Slowikowski, M. Haberka, M. Lachor-Broda, M. Biedron, Z. Gasior, M. Kołodziej, M. Janion, I. Gorczyca-Michta, B. Wozakowska-Kaplon, M. Stasiak, P. Jakubowski, T. Ciurus, J. Drozdz, M. Simiera, P. Zajac, T. Wcislo, P. Zycinski, J. Kasprzak, A. Olejnik, E. Harc-Dyl, J. Miarka, M. Pasieka, M. Ziemińska-Łuć, W. Bujak, A. Śliwiński, A. Grech, J. Morka, K. Petrykowska, M. Prasał, G. Hordyński, P. Feusette, P. Lipski, A. Wester, W. Streb, J. Romanek, P. Woźniak, M. Chlebuś, P. Szafarz, W. Stanik, M. Zakrzewski, J. Kaźmierczak, A. Przybylska, E. Skorek, H. Błaszczyk, M. Stępień, S. Szabowski, W. Krysiak, M. Szymańska, J. Karasiński, J. Blicharz, M. Skura, K. Hałas, L. Michalczyk, Z. Orski, K. Krzyżanowski, A. Skrobowski, L. Zieliński, M. Tomaszewska-Kiecana, M. Dłużniewski, M. Kiliszek, M. Peller, M. Budnik, P. Balsam, G. Opolski, A. Tymińska, K. Ozierański, A. Wancerz, A. Borowiec, E. Majos, R. Dabrowski, H. Szwed, A. Musialik-Lydka, A. Leopold-Jadczyk, E. Jedrzejczyk-Patej, M. Koziel, M. Mazurek, K. Krzemien-Wolska, P. Starosta, E. Nowalany-Kozielska, A. Orzechowska, M. Szpot, M. Staszel, S. Almeida, H. Pereira, L. Brandão Alves, R. Miranda, L. Ribeiro, F. Costa, F. Morgado, P. Carmo, P. Galvao Santos, R. Bernardo, P. Adragão, G. Ferreira da Silva, M. Peres, M. Alves, M. Leal, A. Cordeiro, P. Magalhães, P. Fontes, S. Leão, A. Delgado, A. Costa, B. Marmelo, B. Rodrigues, D. Moreira, J. Santos, L. Santos, A. Terchet, D. Darabantiu, S. Mercea, V. Turcin Halka, A. Pop Moldovan, A. Gabor, B. Doka, G. Catanescu, H. Rus, L. Oboroceanu, E. Bobescu, R. Popescu, A. Dan, A. Buzea, I. Daha, G. Dan, I. Neuhoff, M. Baluta, R. Ploesteanu, N. Dumitrache, M. Vintila, A. Daraban, C. Japie, E. Badila, H. Tewelde, M. Hostiuc, S. Frunza, E. Tintea, D. Bartos, A. Ciobanu, I. Popescu, N. Toma, C. Gherghinescu, D. Cretu, N. Patrascu, C. Stoicescu, C. Udroiu, G. Bicescu, V. Vintila, D. Vinereanu, M. Cinteza, R. Rimbas, M. Grecu, A. Cozma, F. Boros, M. Ille, O. Tica, R. Tor, A. Corina, A. Jeewooth, B. Maria, C. Georgiana, C. Natalia, D. Alin, D. Dinu-Andrei, M. Livia, R. Daniela, R. Larisa, S. Umaar, T. Tamara, M. Ioachim Popescu, D. Nistor, I. Sus, O. Coborosanu, N. Alina-Ramona, R. Dan, L. Petrescu, G. Ionescu, C. Vacarescu, E. Goanta, M. Mangea, A. Ionac, C. Mornos, D. Cozma, S. Pescariu, E. Solodovnicova, I. Soldatova, J. Shutova, L. Tjuleneva, T. Zubova, V. Uskov, D. Obukhov, G. Rusanova, N. Isakova, S. Odinsova, T. Arhipova, E. Kazakevich, O. Zavyalova, T. Novikova, I. Riabaia, S. Zhigalov, E. Drozdova, I. Luchkina, Y. Monogarova, D. Hegya, L. Rodionova, V. Nevzorova, O. Lusanova, A. Arandjelovic, D. Toncev, L. Vukmirovic, M. Radisavljevic, M. Milanov, N. Sekularac, M. Zdravkovic, S. Hinic, S. Dimkovic, T. Acimovic, J. Saric, S. Radovanovic, A. Kocijancic, B. Obrenovic-Kircanski, D. Kalimanovska Ostric, D. Simic, I. Jovanovic, I. Petrovic, M. Polovina, M. Vukicevic, M. Tomasevic, N. Mujovic, N. Radivojevic, O. Petrovic, S. Aleksandric, V. Kovacevic, Z. Mijatovic, B. Ivanovic, M. Tesic, A. Ristic, B. Vujisic-Tesic, M. Nedeljkovic, A. Karadzic, A. Uscumlic, M. Prodanovic, M. Zlatar, M. Asanin, B. Bisenic, V. Vasic, Z. Popovic, D. Djikic, M. Sipic, V. Peric, B. Dejanovic, N. Milosevic, S. Backovic, A. Stevanovic, A. Andric, B. Pencic, M. Pavlovic-Kleut, V. Celic, M. Pavlovic, M. Petrovic, M. Vuleta, N. Petrovic, S. Simovic, Z. Savovic, S. Milanov, G. Davidovic, V. Iric-Cupic, D. Djordjevic, M. Damjanovic, S. Zdravkovic, V. Topic, D. Stanojevic, M. Randjelovic, R. Jankovic-Tomasevic, V. Atanaskovic, S. Antic, D. Simonovic, M. Stojanovic, S. Stojanovic, V. Mitic, V. Ilic, D. Petrovic, M. Deljanin Ilic, S. Ilic, V. Stoickov, S. Markovic, A. Mijatovic, D. Tanasic, G. Radakovic, J. Peranovic, N. Panic-Jelic, O. Vujadinovic, P. Pajic, S. Bekic, S. Kovacevic, A. García Fernandez, A. Perez Cabeza, M. Anguita, L. Tercedor Sanchez, E. Mau, J. Loayssa, M. Ayarra, M. Carpintero, I. Roldán Rabadan, M. Gil Ortega, A. Tello Montoliu, E. Orenes Piñero, S. Manzano Fernández, F. Marín, A. Romero Aniorte, A. Veliz Martínez, M. Quintana Giner, G. Ballesteros, M. Palacio, O. Alcalde, I. García-Bolao, V. Bertomeu Gonzalez, F. Otero-Raviña, J. García Seara, J. Gonzalez Juanatey, N. Dayal, P. Maziarski, P. Gentil-Baron, M. Koç, E. Onrat, I.E. Dural, K. Yilmaz, B. Özin, S. Tan Kurklu, Y. Atmaca, U. Canpolat, L. Tokgozoglu, A.K. Dolu, B. Demirtas, D. Sahin, O. Ozcan Celebi, G. Gagirci, U.O. Turk, H. Ari, N. Polat, N. Toprak, M. Sucu, O. Akin Serdar, A. Taha Alper, A. Kepez, Y. Yuksel, A. Uzunselvi, S. Yuksel, M. Sahin, O. Kayapinar, T. Ozcan, H. Kaya, M.B. Yilmaz, M. Kutlu, M. Demir, C. Gibbs, S. Kaminskiene, M. Bryce, A. Skinner, G. Belcher, J. Hunt, L. Stancombe, B. Holbrook, C. Peters, S. Tettersell, A. Shantsila, K. Senoo, M. Proietti, K. Russell, P. Domingos, S. Hussain, J. Partridge, R. Haynes, S. Bahadur, R. Brown, S. McMahon, J. McDonald, K. Balachandran, R. Singh, S. Garg, H. Desai, K. Davies, W. Goddard, G. Galasko, I. Rahman, Y. Chua, O. Payne, S. Preston, O. Brennan, L. Pedley, C. Whiteside, C. Dickinson, J. Brown, K. Jones, L. Benham, R. Brady, L. Buchanan, A. Ashton, H. Crowther, H. Fairlamb, S. Thornthwaite, C. Relph, A. McSkeane, U. Poultney, N. Kelsall, P. Rice, T. Wilson, M. Wrigley, R. Kaba, T. Patel, E. Young, J. Law, C. Runnett, H. Thomas, H. McKie, J. Fuller, S. Pick, A. Sharp, A. Hunt, K. Thorpe, C. Hardman, E. Cusack, L. Adams, M. Hough, S. Keenan, A. Bowring, J. Watts, J. Zaman, K. Goffin, H. Nutt, Y. Beerachee, J. Featherstone, C. Mills, J. Pearson, L. Stephenson, S. Grant, A. Wilson, C. Hawksworth, I. Alam, M. Robinson, S. Ryan, R. Egdell, E. Gibson, M. Holland, D. Leonard, B. Mishra, S. Ahmad, H. Randall, J. Hill, L. Reid, M. George, S. McKinley, L. Brockway, W. Milligan, J. Sobolewska, J. Muir, L. Tuckis, L. Winstanley, P. Jacob, S. Kaye, L. Morby, A. Jan, T. Sewell, C. Boos, B. Wadams, C. Cope, P. Jefferey, N. Andrews, A. Getty, A. Suttling, C. Turner, K. Hudson, R. Austin, S. Howe, R. Iqbal, N. Gandhi, K. Brophy, P. Mirza, E. Willard, S. Collins, N. Ndlovu, E. Subkovas, V. Karthikeyan, L. Waggett, A. Wood, A. Bolger, J. Stockport, L. Evans, E. Harman, J. Starling, L. Williams, V. Saul, M. Sinha, L. Bell, S. Tudgay, S. Kemp, L. Frost, T. Ingram, A. Loughlin, C. Adams, M. Adams, F. Hurford, C. Owen, C. Miller, D. Donaldson, H. Tivenan, H. Button, A. Nasser, O. Jhagra, B. Stidolph, C. Brown, C. Livingstone, M. Duffy, P. Madgwick, P. Roberts, E. Greenwood, L. Fletcher, M. Beveridge, S. Earles, D. McKenzie, D. Beacock, M. Dayer, M. Seddon, D. Greenwell, F. Luxton, F. Venn, H. Mills, J. Rewbury, K. James, K. Roberts, L. Tonks, D. Felmeden, W. Taggu, A. Summerhayes, D. Hughes, J. Sutton, L. Felmeden, M. Khan, E. Walker, L. Norris, L. O'Donohoe, A. Mozid, H. Dymond, H. Lloyd-Jones, G. Saunders, D. Simmons, D. Coles, D. Cotterill, S. Beech, S. Kidd, B. Wrigley, S. Petkar, A. Smallwood, R. Jones, E. Radford, S. Milgate, S. Metherell, V. Cottam, C. Buckley, A. Broadley, D. Wood, J. Allison, K. Rennie, L. Balian, L. Howard, L. Pippard, S. Board, T. Pitt-Kerby, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Océan du Large et Variabilité Climatique (OLVAC), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Uppsala University, University of Belgrade [Belgrade], CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), and Université de Tours (UT)

Subjects
Kardiologi, General Practice, Cohort, Anticoagulants, MACE, Endocrinology and Diabetes, Prognosis, [SHS]Humanities and Social Sciences, Allmänmedicin, Stroke, Risk Factors, Healthcare resource utilisation, Mortality, Prevalence, Endokrinologi och diabetes, Atrial Fibrillation, Internal Medicine, Diabetes Mellitus, Quality of Life, Humans, Cardiac and Cardiovascular Systems, Prospective Studies, Registries, Aged
Abstract

BACKGROUND: The prevalence of atrial fibrillation(AF) and diabetes mellitus is rising to epidemic proportions. We aimed to assess the impact of diabetes on the management and outcomes of patients with AF.METHODS: The EORP-AF General Long-Term Registry is a prospective, observational registry from 250 centres across 27 European countries. Outcomes of interest were as follows: i)rhythm control interventions; ii)quality of life; iii)healthcare resource utilisation; and iv)major adverse events.RESULTS: Of 11,028 patients with AF, the median age was 71 (63-77) years and 2537 (23.0%) had diabetes. Median follow-up was 24 months. Diabetes was related to increased use of anticoagulation but less rhythm control interventions. Using multivariable analysis, at 2-year follow-up, patients with diabetes were associated with greater levels of anxiety (p = 0.038) compared to those without diabetes. Overall, diabetes was associated with worse health during follow-up, as indicated by Health Utility Score and Visual Analogue Scale. Healthcare resource utilisation was greater with diabetes in terms of length of hospital stay (8.1 (±8.2) vs. 6.1 (±6.7) days); cardiology and internal medicine/general practitioner visits; and emergency room admissions. Diabetes was an independent risk factor of major adverse cardiovascular event (MACE; HR 1.26 [95% CI, 1.04-1.52]), all-cause mortality (HR 1.28 [95% CI, 1.08-1.52]), and cardiovascular mortality (HR 1.41 [95% CI, 1.09-1.83]).CONCLUSION: In this contemporary AF cohort, diabetes was present in 1 in 4 patients and it served as an independent risk factor for reduced quality of life, greater healthcare resource utilisation and excess MACE, all-cause mortality and cardiovascular mortality. There was increased use of anticoagulation therapy in diabetes but with less rhythm control interventions.

Published
2022
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12. Efficacy and Safety of Myrtol® Standardized in the Treatment of Acute and Chronic Rhinosinusitis: A Review of Literature

Author

Aleksandar Peric, Tanja Kosak Soklic, Aleksandra Aleksic, Gabriela Kopacheva-Barsova, and Aneta V. Peric

Subjects
medicinal, medicine.medical_specialty, lcsh:R5-920, rhinitis, business.industry, Chronic rhinosinusitis, plants, sinusitis, herbal medicine, medicine, Intensive care medicine, business, lcsh:Medicine (General)
Abstract

The clinical pattern of rhinosinusitis is based on key symptoms, such as nasal obstruction/congestion, nasal secretion with postnasal discharge, facial pain with pressure, and impaired sense of smell. Acute rhinosinusitis is a viral infection commonly caused by impaired paranasal sinus aeration and drainage and can progress to bacterial superinfection. Chronic rhinosinusitis is an inflammatory disease of the sinonasal mucosa with symptoms persisting for more than 12 weeks. This paper aimed to summarize and update the literature related to the use of herbal product Myrtol® standardized in the treatment of acute and chronic rhinosinusitis. Earlier investigations have demonstrated that Myrtol® standardized has strong secretolytic, secretomotoric, anti-inflammatory, antioxidative, and antimicrobial effects. Therefore, this study reviewed randomized studies related to its use in the treatment of upper-airway inflammations and discussed the mechanisms of action of this herbal drug on infected nasal and paranasal sinuses mucosa.

Published
2020

13. Cardiac troponins and adverse outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EORP atrial fibrillation general long-term registry

Author

Marco Vitolo, Vincenzo L. Malavasi, Marco Proietti, Igor Diemberger, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Luigi Tavazzi, Aldo Pietro Maggioni, Deirdre A. Lane, Gregory Y.H. Lip, Giuseppe Boriani, G. Boriani, G.Y.H. Lip, L. Tavazzi, A.P. Maggioni, G-A. Dan, T. Potpara, M. Nabauer, F. Marin, Z. Kalarus, L. Fauchier, A. Goda, G. Mairesse, T. Shalganov, L. Antoniades, M. Taborsky, S. Riahi, P. Muda, I. García Bolao, O. Piot, K. Etsadashvili, M. Haim, A. Azhari, J. Najafian, M. Santini, E. Mirrakhimov, K. Kulzida, A. Erglis, L. Poposka, M.R. Burg, H. Crijns, Ö. Erküner, D. Atar, R. Lenarczyk, M. Martins Oliveira, D. Shah, E. Serdechnaya, E. Diker, E. Zëra, U. Ekmekçiu, V. Paparisto, M. Tase, H. Gjergo, J. Dragoti, M. Ciutea, N. Ahadi, Z. el Husseini, M. Raepers, J. Leroy, P. Haushan, A. Jourdan, C. Lepiece, L. Desteghe, J. Vijgen, P. Koopman, G. Van Genechten, H. Heidbuchel, T. Boussy, M. De Coninck, H. Van Eeckhoutte, N. Bouckaert, A. Friart, J. Boreux, C. Arend, P. Evrard, L. Stefan, E. Hoffer, J. Herzet, M. Massoz, C. Celentano, M. Sprynger, L. Pierard, P. Melon, B. Van Hauwaert, C. Kuppens, D. Faes, D. Van Lier, A. Van Dorpe, A. Gerardy, O. Deceuninck, O. Xhaet, F. Dormal, E. Ballant, D. Blommaert, D. Yakova, M. Hristov, T. Yncheva, N. Stancheva, S. Tisheva, M. Tokmakova, F. Nikolov, D. Gencheva, B. Kunev, M. Stoyanov, D. Marchov, V. Gelev, V. Traykov, A. Kisheva, H. Tsvyatkov, R. Shtereva, S. Bakalska-Georgieva, S. Slavcheva, Y. Yotov, M. Kubíčková, A. Marni Joensen, A. Gammelmark, L. Hvilsted Rasmussen, P. Dinesen, S. Krogh Venø, B. Sorensen, A. Korsgaard, K. Andersen, C. Fragtrup Hellum, A. Svenningsen, O. Nyvad, P. Wiggers, O. May, A. Aarup, B. Graversen, L. Jensen, M. Andersen, M. Svejgaard, S. Vester, S. Hansen, V. Lynggaard, M. Ciudad, R. Vettus, A. Maestre, S. Castaño, S. Cheggour, J. Poulard, V. Mouquet, S. Leparrée, J. Bouet, J. Taieb, A. Doucy, H. Duquenne, A. Furber, J. Dupuis, J. Rautureau, M. Font, P. Damiano, M. Lacrimini, J. Abalea, S. Boismal, T. Menez, J. Mansourati, G. Range, H. Gorka, C. Laure, C. Vassalière, N. Elbaz, N. Lellouche, K. Djouadi, F. Roubille, D. Dietz, J. Davy, M. Granier, P. Winum, C. Leperchois-Jacquey, H. Kassim, E. Marijon, J. Le Heuzey, J. Fedida, C. Maupain, C. Himbert, E. Gandjbakhch, F. Hidden-Lucet, G. Duthoit, N. Badenco, T. Chastre, X. Waintraub, M. Oudihat, J. Lacoste, C. Stephan, H. Bader, N. Delarche, L. Giry, D. Arnaud, C. Lopez, F. Boury, I. Brunello, M. Lefèvre, R. Mingam, M. Haissaguerre, M. Le Bidan, D. Pavin, V. Le Moal, C. Leclercq, T. Beitar, I. Martel, A. Schmid, N. Sadki, C. Romeyer-Bouchard, A. Da Costa, I. Arnault, M. Boyer, C. Piat, N. Lozance, S. Nastevska, A. Doneva, B. Fortomaroska Milevska, B. Sheshoski, K. Petroska, N. Taneska, N. Bakrecheski, K. Lazarovska, S. Jovevska, V. Ristovski, A. Antovski, E. Lazarova, I. Kotlar, J. Taleski, S. Kedev, N. Zlatanovik, S. Jordanova, T. Bajraktarova Proseva, S. Doncovska, D. Maisuradze, A. Esakia, E. Sagirashvili, K. Lartsuliani, N. Natelashvili, N. Gumberidze, R. Gvenetadze, N. Gotonelia, N. Kuridze, G. Papiashvili, I. Menabde, S. Glöggler, A. Napp, C. Lebherz, H. Romero, K. Schmitz, M. Berger, M. Zink, S. Köster, J. Sachse, E. Vonderhagen, G. Soiron, K. Mischke, R. Reith, M. Schneider, W. Rieker, D. Boscher, A. Taschareck, A. Beer, D. Oster, O. Ritter, J. Adamczewski, S. Walter, A. Frommhold, E. Luckner, J. Richter, M. Schellner, S. Landgraf, S. Bartholome, R. Naumann, J. Schoeler, D. Westermeier, F. William, K. Wilhelm, M. Maerkl, R. Oekinghaus, M. Denart, M. Kriete, U. Tebbe, T. Scheibner, M. Gruber, A. Gerlach, C. Beckendorf, L. Anneken, M. Arnold, S. Lengerer, Z. Bal, C. Uecker, H. Förtsch, S. Fechner, V. Mages, E. Martens, H. Methe, T. Schmidt, B. Schaeffer, B. Hoffmann, J. Moser, K. Heitmann, S. Willems, C. Klaus, I. Lange, M. Durak, E. Esen, F. Mibach, H. Mibach, A. Utech, M. Gabelmann, R. Stumm, V. Ländle, C. Gartner, C. Goerg, N. Kaul, S. Messer, D. Burkhardt, C. Sander, R. Orthen, S. Kaes, A. Baumer, F. Dodos, A. Barth, G. Schaeffer, J. Gaertner, J. Winkler, A. Fahrig, J. Aring, I. Wenzel, S. Steiner, A. Kliesch, E. Kratz, K. Winter, P. Schneider, A. Haag, I. Mutscher, R. Bosch, J. Taggeselle, S. Meixner, A. Schnabel, A. Shamalla, H. Hötz, A. Korinth, C. Rheinert, G. Mehltretter, B. Schön, N. Schön, A. Starflinger, E. Englmann, G. Baytok, T. Laschinger, G. Ritscher, A. Gerth, D. Dechering, L. Eckardt, M. Kuhlmann, N. Proskynitopoulos, J. Brunn, K. Foth, C. Axthelm, H. Hohensee, K. Eberhard, S. Turbanisch, N. Hassler, A. Koestler, G. Stenzel, D. Kschiwan, M. Schwefer, S. Neiner, S. Hettwer, M. Haeussler-Schuchardt, R. Degenhardt, S. Sennhenn, M. Brendel, A. Stoehr, W. Widjaja, S. Loehndorf, A. Logemann, J. Hoskamp, J. Grundt, M. Block, R. Ulrych, A. Reithmeier, V. Panagopoulos, C. Martignani, D. Bernucci, E. Fantecchi, I. Diemberger, M. Ziacchi, M. Biffi, P. Cimaglia, J. Frisoni, I. Giannini, S. Boni, S. Fumagalli, S. Pupo, A. Di Chiara, P. Mirone, F. Pesce, C. Zoccali, V.L. Malavasi, A. Mussagaliyeva, B. Ahyt, Z. Salihova, K. Koshum-Bayeva, A. Kerimkulova, A. Bairamukova, B. Lurina, R. Zuzans, S. Jegere, I. Mintale, K. Kupics, K. Jubele, O. Kalejs, K. Vanhear, M. Burg, M. Cachia, E. Abela, S. Warwicker, T. Tabone, R. Xuereb, D. Asanovic, D. Drakalovic, M. Vukmirovic, N. Pavlovic, L. Music, N. Bulatovic, A. Boskovic, H. Uiterwaal, N. Bijsterveld, J. De Groot, J. Neefs, N. van den Berg, F. Piersma, A. Wilde, V. Hagens, J. Van Es, J. Van Opstal, B. Van Rennes, H. Verheij, W. Breukers, G. Tjeerdsma, R. Nijmeijer, D. Wegink, R. Binnema, S. Said, S. Philippens, W. van Doorn, T. Szili-Torok, R. Bhagwandien, P. Janse, A. Muskens, M. van Eck, R. Gevers, N. van der Ven, A. Duygun, B. Rahel, J. Meeder, A. Vold, C. Holst Hansen, I. Engset, B. Dyduch-Fejklowicz, E. Koba, M. Cichocka, A. Sokal, A. Kubicius, E. Pruchniewicz, A. Kowalik-Sztylc, W. Czapla, I. Mróz, M. Kozlowski, T. Pawlowski, M. Tendera, A. Winiarska-Filipek, A. Fidyk, A. Slowikowski, M. Haberka, M. Lachor-Broda, M. Biedron, Z. Gasior, M. Kołodziej, M. Janion, I. Gorczyca-Michta, B. Wozakowska-Kaplon, M. Stasiak, P. Jakubowski, T. Ciurus, J. Drozdz, M. Simiera, P. Zajac, T. Wcislo, P. Zycinski, J. Kasprzak, A. Olejnik, E. Harc-Dyl, J. Miarka, M. Pasieka, M. Ziemińska-Łuć, W. Bujak, A. Śliwiński, A. Grech, J. Morka, K. Petrykowska, M. Prasał, G. Hordyński, P. Feusette, P. Lipski, A. Wester, W. Streb, J. Romanek, P. Woźniak, M. Chlebuś, P. Szafarz, W. Stanik, M. Zakrzewski, J. Kaźmierczak, A. Przybylska, E. Skorek, H. Błaszczyk, M. Stępień, S. Szabowski, W. Krysiak, M. Szymańska, J. Karasiński, J. Blicharz, M. Skura, K. Hałas, L. Michalczyk, Z. Orski, K. Krzyżanowski, A. Skrobowski, L. Zieliński, M. Tomaszewska-Kiecana, M. Dłużniewski, M. Kiliszek, M. Peller, M. Budnik, P. Balsam, G. Opolski, A. Tymińska, K. Ozierański, A. Wancerz, A. Borowiec, E. Majos, R. Dabrowski, H. Szwed, A. Musialik-Lydka, A. Leopold-Jadczyk, E. Jedrzejczyk-Patej, M. Koziel, M. Mazurek, K. Krzemien-Wolska, P. Starosta, E. Nowalany-Kozielska, A. Orzechowska, M. Szpot, M. Staszel, S. Almeida, H. Pereira, L. Brandão Alves, R. Miranda, L. Ribeiro, F. Costa, F. Morgado, P. Carmo, P. Galvao Santos, R. Bernardo, P. Adragão, G. Ferreira da Silva, M. Peres, M. Alves, M. Leal, A. Cordeiro, P. Magalhães, P. Fontes, S. Leão, A. Delgado, A. Costa, B. Marmelo, B. Rodrigues, D. Moreira, J. Santos, L. Santos, A. Terchet, D. Darabantiu, S. Mercea, V. Turcin Halka, A. Pop Moldovan, A. Gabor, B. Doka, G. Catanescu, H. Rus, L. Oboroceanu, E. Bobescu, R. Popescu, A. Dan, A. Buzea, I. Daha, G. Dan, I. Neuhoff, M. Baluta, R. Ploesteanu, N. Dumitrache, M. Vintila, A. Daraban, C. Japie, E. Badila, H. Tewelde, M. Hostiuc, S. Frunza, E. Tintea, D. Bartos, A. Ciobanu, I. Popescu, N. Toma, C. Gherghinescu, D. Cretu, N. Patrascu, C. Stoicescu, C. Udroiu, G. Bicescu, V. Vintila, D. Vinereanu, M. Cinteza, R. Rimbas, M. Grecu, A. Cozma, F. Boros, M. Ille, O. Tica, R. Tor, A. Corina, A. Jeewooth, B. Maria, C. Georgiana, C. Natalia, D. Alin, D. Dinu-Andrei, M. Livia, R. Daniela, R. Larisa, S. Umaar, T. Tamara, M. Ioachim Popescu, D. Nistor, I. Sus, O. Coborosanu, N. Alina-Ramona, R. Dan, L. Petrescu, G. Ionescu, C. Vacarescu, E. Goanta, M. Mangea, A. Ionac, C. Mornos, D. Cozma, S. Pescariu, E. Solodovnicova, I. Soldatova, J. Shutova, L. Tjuleneva, T. Zubova, V. Uskov, D. Obukhov, G. Rusanova, N. Isakova, S. Odinsova, T. Arhipova, E. Kazakevich, O. Zavyalova, T. Novikova, I. Riabaia, S. Zhigalov, E. Drozdova, I. Luchkina, Y. Monogarova, D. Hegya, L. Rodionova, V. Nevzorova, O. Lusanova, A. Arandjelovic, D. Toncev, L. Vukmirovic, M. Radisavljevic, M. Milanov, N. Sekularac, M. Zdravkovic, S. Hinic, S. Dimkovic, T. Acimovic, J. Saric, S. Radovanovic, A. Kocijancic, B. Obrenovic-Kircanski, D. Kalimanovska Ostric, D. Simic, I. Jovanovic, I. Petrovic, M. Polovina, M. Vukicevic, M. Tomasevic, N. Mujovic, N. Radivojevic, O. Petrovic, S. Aleksandric, V. Kovacevic, Z. Mijatovic, B. Ivanovic, M. Tesic, A. Ristic, B. Vujisic-Tesic, M. Nedeljkovic, A. Karadzic, A. Uscumlic, M. Prodanovic, M. Zlatar, M. Asanin, B. Bisenic, V. Vasic, Z. Popovic, D. Djikic, M. Sipic, V. Peric, B. Dejanovic, N. Milosevic, S. Backovic, A. Stevanovic, A. Andric, B. Pencic, M. Pavlovic-Kleut, V. Celic, M. Pavlovic, M. Petrovic, M. Vuleta, N. Petrovic, S. Simovic, Z. Savovic, S. Milanov, G. Davidovic, V. Iric-Cupic, D. Djordjevic, M. Damjanovic, S. Zdravkovic, V. Topic, D. Stanojevic, M. Randjelovic, R. Jankovic-Tomasevic, V. Atanaskovic, S. Antic, D. Simonovic, M. Stojanovic, S. Stojanovic, V. Mitic, V. Ilic, D. Petrovic, M. Deljanin Ilic, S. Ilic, V. Stoickov, S. Markovic, A. Mijatovic, D. Tanasic, G. Radakovic, J. Peranovic, N. Panic-Jelic, O. Vujadinovic, P. Pajic, S. Bekic, S. Kovacevic, A. García Fernandez, A. Perez Cabeza, M. Anguita, L. Tercedor Sanchez, E. Mau, J. Loayssa, M. Ayarra, M. Carpintero, I. Roldán Rabadan, M. Gil Ortega, A. Tello Montoliu, E. Orenes Piñero, S. Manzano Fernández, F. Marín, A. Romero Aniorte, A. Veliz Martínez, M. Quintana Giner, G. Ballesteros, M. Palacio, O. Alcalde, I. García-Bolao, V. Bertomeu Gonzalez, F. Otero-Raviña, J. García Seara, J. Gonzalez Juanatey, N. Dayal, P. Maziarski, P. Gentil-Baron, M. Koç, E. Onrat, I.E. Dural, K. Yilmaz, B. Özin, S. Tan Kurklu, Y. Atmaca, U. Canpolat, L. Tokgozoglu, A.K. Dolu, B. Demirtas, D. Sahin, O. Ozcan Celebi, G. Gagirci, U.O. Turk, H. Ari, N. Polat, N. Toprak, M. Sucu, O. Akin Serdar, A. Taha Alper, A. Kepez, Y. Yuksel, A. Uzunselvi, S. Yuksel, M. Sahin, O. Kayapinar, T. Ozcan, H. Kaya, M.B. Yilmaz, M. Kutlu, M. Demir, C. Gibbs, S. Kaminskiene, M. Bryce, A. Skinner, G. Belcher, J. Hunt, L. Stancombe, B. Holbrook, C. Peters, S. Tettersell, A. Shantsila, D. Lane, K. Senoo, M. Proietti, K. Russell, P. Domingos, S. Hussain, J. Partridge, R. Haynes, S. Bahadur, R. Brown, S. McMahon, J. McDonald, K. Balachandran, R. Singh, S. Garg, H. Desai, K. Davies, W. Goddard, G. Galasko, I. Rahman, Y. Chua, O. Payne, S. Preston, O. Brennan, L. Pedley, C. Whiteside, C. Dickinson, J. Brown, K. Jones, L. Benham, R. Brady, L. Buchanan, A. Ashton, H. Crowther, H. Fairlamb, S. Thornthwaite, C. Relph, A. McSkeane, U. Poultney, N. Kelsall, P. Rice, T. Wilson, M. Wrigley, R. Kaba, T. Patel, E. Young, J. Law, C. Runnett, H. Thomas, H. McKie, J. Fuller, S. Pick, A. Sharp, A. Hunt, K. Thorpe, C. Hardman, E. Cusack, L. Adams, M. Hough, S. Keenan, A. Bowring, J. Watts, J. Zaman, K. Goffin, H. Nutt, Y. Beerachee, J. Featherstone, C. Mills, J. Pearson, L. Stephenson, S. Grant, A. Wilson, C. Hawksworth, I. Alam, M. Robinson, S. Ryan, R. Egdell, E. Gibson, M. Holland, D. Leonard, B. Mishra, S. Ahmad, H. Randall, J. Hill, L. Reid, M. George, S. McKinley, L. Brockway, W. Milligan, J. Sobolewska, J. Muir, L. Tuckis, L. Winstanley, P. Jacob, S. Kaye, L. Morby, A. Jan, T. Sewell, C. Boos, B. Wadams, C. Cope, P. Jefferey, N. Andrews, A. Getty, A. Suttling, C. Turner, K. Hudson, R. Austin, S. Howe, R. Iqbal, N. Gandhi, K. Brophy, P. Mirza, E. Willard, S. Collins, N. Ndlovu, E. Subkovas, V. Karthikeyan, L. Waggett, A. Wood, A. Bolger, J. Stockport, L. Evans, E. Harman, J. Starling, L. Williams, V. Saul, M. Sinha, L. Bell, S. Tudgay, S. Kemp, L. Frost, T. Ingram, A. Loughlin, C. Adams, M. Adams, F. Hurford, C. Owen, C. Miller, D. Donaldson, H. Tivenan, H. Button, A. Nasser, O. Jhagra, B. Stidolph, C. Brown, C. Livingstone, M. Duffy, P. Madgwick, P. Roberts, E. Greenwood, L. Fletcher, M. Beveridge, S. Earles, D. McKenzie, D. Beacock, M. Dayer, M. Seddon, D. Greenwell, F. Luxton, F. Venn, H. Mills, J. Rewbury, K. James, K. Roberts, L. Tonks, D. Felmeden, W. Taggu, A. Summerhayes, D. Hughes, J. Sutton, L. Felmeden, M. Khan, E. Walker, L. Norris, L. O'Donohoe, A. Mozid, H. Dymond, H. Lloyd-Jones, G. Saunders, D. Simmons, D. Coles, D. Cotterill, S. Beech, S. Kidd, B. Wrigley, S. Petkar, A. Smallwood, R. Jones, E. Radford, S. Milgate, S. Metherell, V. Cottam, C. Buckley, A. Broadley, D. Wood, J. Allison, K. Rennie, L. Balian, L. Howard, L. Pippard, S. Board, and T. Pitt-Kerby

Subjects
Male, AF registry, Atrial fibrillation, Biomarkers, Death, Major adverse cardiovascular events, outcomes, Troponins, Troponin, Risk Factors, Atrial Fibrillation, Internal Medicine, Humans, Female, Prospective Studies, Registries, Aged
Abstract

BACKGROUND: Cardiac troponins (cTn) have been reported to be predictors for adverse outcomes in atrial fibrillation (AF), patients, but their actual use is still unclear.AIM: To assess the factors associated with cTn testing in routine practice and evaluate the association with outcomes.METHODS: Patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry were stratified into 3 groups according to cTn levels as (i) cTn not tested, (ii) cTn in range (≤99th percentile), (iii) cTn elevated (>99th percentile). The composite outcome of any thromboembolism /any acute coronary syndrome/cardiovascular (CV) death, defined as Major Adverse Cardiovascular Events (MACE) and all-cause death were the main endpoints.RESULTS: Among 10 445 AF patients (median age 71 years, 40.3% females) cTn were tested in 2834 (27.1%). cTn was elevated in 904/2834 (31.9%) and in-range in 1930/2834 (68.1%) patients. Female sex, in-hospital enrollment, first-detected AF, CV risk factors, history of coronary artery disease, and atypical AF symptoms were independently associated with cTn testing. Elevated cTn were independently associated with a higher risk for MACE (Model 1, hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.40-2.16, Model 2, HR 1.62, 95% CI 1.28-2.05; Model 3 HR 1.76, 95% CI 1.37-2.26) and all-cause death (Model 1, HR 1.45, 95% CI 1.21-1.74; Model 2, HR 1.36, 95% CI 1.12-1.66; Model 3, HR 1.38, 95% CI 1.12-1.71).CONCLUSIONS: Elevated cTn levels were associated with an increased risk of all-cause mortality and adverse CV events. Clinical factors that might enhance the need to rule out CAD were associated with cTn testing.

Published
2022
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16. Impact of adipose specific peptides on the course and prognosis of myocardial heart attacks

Author

S. Lazić, J. Rasic, B. Dejanovic, D. Rasic, Maja Šipić, G. Nikolic, and V. Peric

Subjects
medicine.medical_specialty, business.industry, lcsh:R, Adipose tissue, nutritional and metabolic diseases, lcsh:Medicine, adipocytokines (adiponectin, Bioinformatics, Surgery, myocardial infarction, resistin), medicine, prognosis of the disease, business, hormones, hormone substitutes, and hormone antagonists
Abstract

Tests have shown that adipose tissue is very important in the production of chemical substances that have a major impact on atherosclerosis. The basic fat cells adiposity is very active in bio secretion hormones and other substances. Adiposities secrete chemical substances such as leptin, resistin, adiponectin, and others who participate in metabolic processes. One of the most important adipocytokine affecting the formation and the regression of atheromas plaque in the coronary blood vessels are adiponectin and resistin. So our aim was to determine the value of the concentration of adiponectin and resistin on patient with myocardial heart attack and determine their correlation with the control group of healthy subjects. In this study were included 68 subjects, 40 with myocardial heart attacks and 28 control groups of normal healthy. In the group with myocardial 78.6% of respondents were male and 21.4% female. Tests have shown that the concentration of adiponectin in the group with myocardial heart attack was significantly lower than the control group (4.94 to 6.74, p=0.043, p 0.05). All this indicates that in patients with myocardial heart attack there is a decline in the concentration of adiponectin, which has cardio protective effect. The increase in resistin in myocardial heart attack in directly related to the appearance of athermanous plaques in the coronary blood vessels and has a bad prognostic significance.

Published
2015

17. Changes in plasma brain natriuretic peptide levels during exercise stress echocardiography tests in patients with idiopathic dilated cardiomyopathy with or without preserved left ventricular contractile reserve

Author

Maja Šipić, Dijana Djikic, S. Lazić, V. Peric, Aleksandar Jovanovic, S. Sovtic, P. Otasevic, and D. Peric

Subjects
exercise stress echocardiography, medicine.medical_specialty, business.industry, lcsh:R, lcsh:Medicine, Brain natriuretic peptide, dilated cardiomyopathy, contractile reserve, Internal medicine, Idiopathic dilated cardiomyopathy, medicine, Cardiology, In patient, Exercise stress echocardiography, business, BNP
Abstract

Introduction: The study of importance of left ventricular contractile reserve presence and changes plasma brain natriuretic peptide levels (BNP) during exercise in patinets with idiopathic dilated cardiomyopathy is very popular today, but these two parametres have rarely been interconnected. The study of response BNP during echocardiography stress tests in patients with idiopathic dilated cardiomyopathy with or without preserved left ventricular contractile reserve. We studied 55 consecutive patients with idiopathic dilated cardiomyopathy (mean age 54.98 ± 9.84, 49 (89.1%) male) treated in the outpatient clinic for heart failure at the Institute of Cardiovascular Diseases 'Dedinje'. All the patients underwent the echocardiography stress test. Contractile reserve was assessed by measuring of the changes of the left ventricle ejection fraction basally and in the first minute after the strongest stress. Level of BPN was measured at rest, in the first minute and after 20 minutes of maximal exercise stress. Following the kinetics of BNP level during stress testing, we find that in patients with preserved left ventricular contractile reserve BNP level is rising at maximum load achieved (Mediana (IQR) - 59 (22-113) vs. 91 (37-135) vs. 78 (30-159) ng/L, p

Published
2015
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18. Comparative analysis of biochemical parameters of atherosclerosis adiponectin and resistin in patients with diabetes mellitus and coronary heart disease

Author

D. Rasic, J. Rasic, S. Lazić, V. Peric, G. Nikolic, and B. Dejanovic

Subjects
medicine.medical_specialty, adipocyte hormones, Adiponectin, endocrine system diseases, business.industry, lcsh:R, nutritional and metabolic diseases, lcsh:Medicine, medicine.disease, coronary disease, Coronary heart disease, Diabetes mellitus, Internal medicine, diabetes mellitus, medicine, Cardiology, Resistin, In patient, business, hormones, hormone substitutes, and hormone antagonists
Abstract

The most important adipocytokines affecting the formation and the regression of atheromas plaque in the coronary blood vessels are adiponectin and resistin. The essence of this test is to determine the correlation of the leading biochemical parameters of atherosclerosis, adiponectin and resistin and determine their interdependence with other biochemical parameters in patients with diabetes mellitus and coronary heart disease. Our study group consisted of 140 patients and 40 control group (healthy), 50 with diabetes mellitus and 50 with coronary heart disease (myocardial infarction and angina pectoris). We find that the average value of adiponectin in the group with type 2 diabetes mellitus were significantly lower than in the control group (4.38 to 6.74, p = 0.001, p 0.05). In the same study group average value of resistin was significantly higher than in the control group (15.73 to 7.88, p = 0.001, p

Published
2015

20. Electrocardiography changes in patients with acute myocardial infarction in late hospital phase

Author

Z. Marčetić, S. Lazić, V. Peric, S. Sovtic, and Maja Šipić

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, electrocardiography, lcsh:R, Qrs score, acute myocardial infarction, lcsh:Medicine, Electrocardiography in myocardial infarction, medicine.disease, Heart insufficiency, Internal medicine, cardiovascular system, Cardiology, Medicine, In patient, cardiovascular diseases, Myocardial infarction, business, Electrocardiography
Abstract

One of possibilities to estimate size of myocardial injury during the acute myocardial infarction are electrocardiographic changes, forming of QS formation (ECG signs of scares changes). This investigation which included three groups of patients receiving thrombolytic, nitrates or beta blockers in acute phase of myocardial infarction has aim to analyze 12-chanels electrocardiogram and to establish difference between this therapeutics groups in sum of QRS score, but also to indication frequency of periinfarction heart insufficiency in this therapeutics groups, comparing with observed ECG changes. Analysis shows significant differences between groups in value of QRS score, and also significant lower value of QRS score in patients with acute myocardial infarction treated with thrombolytic therapy. This difference relative to other two groups shows lower level of myocardial injury during acute myocardial infarction in patients treating with thrombolytic therapy.

Published
2014
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21. Differences in the clinical characteristics of patients with dilated cardiomyopathy, depending on the presence of preserved left ventricular contractile reserve assessed by exercise stress-echo-cardiography

Author

B. Sovrlic, T. Novaković, Aleksandar Jovanovic, D. Djikic, S. Lazić, D. Aleksovski, Maja Šipić, V. Peric, M. Todorovic, D. Rasic, and B. Dejanovic

Subjects
medicine.medical_specialty, hypertension, business.industry, lcsh:R, Echo (computing), lcsh:Medicine, Dilated cardiomyopathy, Exercise stress, medicine.disease, dilated cardiomyopathy, contractile reserve, Internal medicine, Cardiology, Medicine, business
Abstract

Preserved left ventricular contractile reserve means the ability of poorly contractile myocardial segments to improve their contractility under the influence of different inotropic stimulus. To determine the differences in the clinical features of patients with dilated cardiomyopathy, depending on the preserved left ventricular contractile reserve. The study included 55 consecutive patients with idiopathic dilated cardiomyopathy. All patients included in the study was performed exercise stress echocardiography test according to standard protocol. The presence of preserved contractile reserve was determined using the change in left ventricular ejection fraction. The mean age of patients was 54.98 ± 9.84 years, 49 (89.1%) were males. Based on the changes in left ventricular ejection fraction as a criterion of left ventricular contractile reserve, preserved contractile reserve had 25 patients (45.5%). Patients without preserved left ventricular contractile reserve significantly more frequent have a history of hypertension (46.7 vs. 20.0%, p = 0.038). No significant differences in the prevalence of other risk factors. Patients with preserved left ventricular contractile reserve have a smaller end-systolic left ventricular dimension (49.64 ± 7.26 vs. 55.27 ± 8:36 mm, p = 0.011), smaller end-diastolic (77.35 ± 26.41 vs. 94.59 ± 34.97 ml / m2, p = 0.005) and end-systolic left ventricular volume index (59.31 ± 26.05 vs. 78.62 ± 34.42 ml/m2, p = 0.002), higher left ventricular ejection fraction (25.48 ± 8.32 vs. 18.33 ± 6.49%, p=0.002), and lower wall motion score index (2.23 ± 0.27 vs. 2.48 ± 0.27, p=0.002). Patients with preserved left ventricular contractile reserve less frequently represented with a his­tory of hypertension and significantly less morphologically and functionally damaged left ventricle.

Published
2014
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22. Poster session Friday 13 December - PM: 13/12/2013, 14:00-18:00 * Location: Poster area

Author

A. Rojek, M. Bekbossynova, J. Onaindia, R. Ferrer Lopez, B. Javani, A. Sharif-Rasslan, N. Al, R. Davies, U. Ikeda, R. Ferreira, A. Cincin, M. Plewka, F. Weidemann, B. Fadel, O. Akgul, Z. Frikha, M. Haghjoo, J. Jensen, G. Agoston, M. Sunbul, R. Strasser, M. Pepi, Y. Fuku, M. Minamisawa, J. Holm, O. Dzikowska Diduch, Y. Pya, J. Macancela Quinones, P. Gaudron, G. Ertl, S. Thivolet, C. Koukoulis, H. Yun, S. Iancovici, D. Capodanno, M. Barthelet, A. Medeiros-Domingo, T. Le Tourneau, A. P. Lee, G. Derumeaux, I. Rodriguez, B. Naegeli, S. Rahmatullah, A. Bayes, H. Schaff, A. M. Caggegi, C. Zito, M. D'alto, R. Favilli, J. Baan, M. Aydin, J. Bonaque Gonzalez, A. Akhundova, I. Cruz, R. Karpov, H. Okura, D. Dequanter, M. T. Grillo, A. Ingvarsson, S. Prasad, A. Dahiya, U. Rosenschein, G. Sinagra, J. Kochanowski, M. Niemann, Y. Saijo, B. Bouma, K. Sveric, Y. Topilsky, M. Ministeri, J. Piek, C. Marinescu, M. Bilik, I. Ikuta, M. Al-Admawi, C. Araujo, D. Trifunovic, S. Onciul, G. Pavlidis, F. Ruiz Lopez, M. Oyumlu, C. Kenny, F. Kayan, C. Ginghina, R. Piatkowski, I. Lekuona Goya, A. Almeida, G. Portugal, H. Motoki, M. Cinteza, B. Seifert, S. Lee, M. Banovic, T. Sakakura, A. Pappalardo, B. Stuart, Y. Chuyasova, T. Yamanaka, N. Roche, C. Wunderlich, X. Arana, L. Ernande, V. Ribeiro, Y. Tanabe, L. Vazdar, Y. Tayyareci, E. Malev, M. Eren, J. Gil, S. Lunghetti, D. Krieger, S. Mangiafico, M. Izumo, D. Cacela, A. Kovacs, A E Van Den Bosch, E. Reffo, P. G. Jorgensen, O. Dubourg, J. Abreu, S. Wang, E. Cervesato, K. Theodoropoulos, N. Ozaydogdu, L. Jung, Y. Kijima, E. Ostenfeld, C. Corsi, M. Florescu, M. Chenilleau, K. Yokota, A. Faeh-Gunz, R. Winter, J. Dreyfus, D. Kang, S. K. Saha, S. Surdulli, L. Abikeyeva, M. Marchel, P. Meregalli, M. Yamat, X. Arana Achaga, C. Shahla, V. Palicka, M. Tanaka, A. Galrinho, K. Endo, M. Saravi, J. Bogaert, H. Oeygarden, S. Okabe, J. Reiken, G. Ionescu, C. Selton-Suty, A. Nunes-Diogo, E. S. Davidsen, E. Kinova, A. Bandeira, Y. Seo, S. Hojberg, G. Siblini, M. Pellegrino, M. Ostojic, J. J. Onaindia Gandarias, M. Pereira, F. Antonini-Canterin, F. Akturk, T. Nakajima, M. Al Fayyadh, S. Herrmann, G. Stellin, M. E. Menting, B. Sasko, J. Song, T. Kurokawa, F. Dipasqua, T. Maruo, M. Geleijnse, H. Triantafyllidi, M. Komeda, R. Praus, V. Nesvetov, M. Fineschi, A. Auricchio, M. Dorobantu, A. Degirmencioglu, E. Laraudogoitia Zaldumbide, S. Velasco Del Castillo, Z. Marcetic, U. Waje-Andreassen, F. Fang, K. Farsalinos, L. Vasina, D. Muraru, M. Faludi, P. Rio, S. Peppes, T. Karaahmet, G. Suermeci, P. Maccarthy, S. Kotsovilis, Y. Akashi, G. Di Salvo, Z. Issa, J. Gibbs, A. Poletti, E. Bonnefoy-Cudraz, A. Madej-Pilarczyk, E. Gerdts, K. Solymossy, P. Kogoj, T. Tomita, M. Lisi, K. Suzuki, S. Sifakis, E.A. Surkova, T. Fritz-Hansen, V. Tritakis, E. Romeo, T. Akesson-Lindow, B. Lasota, A. Florian, M. Maciel, K. Gieszczyk-Strozik, M. Imazio, S. Ozyilmaz, K. Kadota, V. Peric, E. Zencirci, B. Tzvetkov, U. Aguirre Larracoechea, D. Caldeira, Y. Motoyoshi, M. Russo, R. Suri, H. Pintaric, O. Celik, D. Himbert, L. Branco, B. Sun, S. Dzhetybayeva, A. Esen Zencirci, M. Ciurzynski, R. Nunyez, B. Iung, K. Takenaka, A. S. Omran, K. Ozden, J. Argacha, S. Pradel, A. M. Pistritto, M. Pfyffer, C. Dedobbeleer, J. Vojacek, P. Costa, E. Albuquerque, A. Tamadoni, B. Sarubbi, M. Carlsson, R. Mogelvang, G. Oria, K. Kimura, E. Kim, F. Kousathana, A. Mateescu, A. Varga, J. Clerc, M. Noni, S. Kyrzopoulos, S. Andossova, S. Almeida, E. Shkolnik, J. Koyama, M. Daimon, S. Saeed, B. Popescu, M. Tigen, R. Wennemann, C. Venner, M. Guazzi, R. Magalhaes, H. Hayashi, M. Salagianni, A. Kiotsekoglou, A. Baggiano, C. Chao, T. Nakao, H. Becher, R. Zeppellini, J. Marrugat, G. Erente, P. Lancellotti, R. Rimbas, D. M'barek, M. Cameli, Y. Katahira, S. Carerj, C. Grasso, P. Moulin, D. Lavergne, B. Merkely, D. Mahoney, C. Tamburino, W. Kosmala, G. Romagna, T. Potpara, T. Ha, R. Biffanti, C. Dundar, E. Gunyeli, L. Weinert, R. Dworakowski, A. Ferreira, T. Biering-Sorensen, H. Engblom, M. Erturk, G. Varlan, M. Ikeda, L. Thorell, S Von Bardeleben, S. Palomar, K. Boerlage-Van Dijk, T. Ishizu, S. Stoerk, I. Germanakis, H. Yamamoto, Q. Shang, A. Borizanova, C. Fiorentini, R. Candinas, U. Inci, F. Macedo, O. Huttin, R. Pudil, I. D. Gabric, C. Silveira, I. Sari, V. Lambadiari, L. Laczmanski, E. Timofeev, A. Izgi, D. Bravo Bustos, K. Wierzbowska-Drabik, P. Masci, H. Pusuroglu, F. Navarro Garcia, P. Adhikari, K. Mizia-Stec, S. Celik, A. Medressova, S. Pala, R. Retkoceri, O. Tautu, S. Tzikas, S. Ohtsuki, T. Akbulut, S. Goliszek, K. Mitsudo, P. Palczewski, A. Spyrou, K. Filipiak, I. Tzoulaki, A. Erdem, M. Krupa, K. Yoshida, M. Polovina, J. Vanoverschelde, H. Pereira, K. Obase, O. V. Tereshina, J. Liebeton, L. Petrescu, W. Gin-Sing, T. A. Warsame, B. Lichodziejewska, M. Takeuchi, J. Cuypers, Y. Jung, E. Martins, S. Mondillo, D. Liu, D. Planinc, I. Subirana, S. Shahrzad, U. Richter, M. Prull, C.H. Attenhofer Jost, E. Alfonzetti, A. Kosztin, V. Carvalho, M. van Bracht, K. Shahgaldi, M. Altman, A. Cacicedo, R. Dulgheru, M. Arslan, L. Dell'angela, M. De Biasio, J. Roos-Hesselink, A. Sawant, B. Ghadrdoust, H. Tabuchi, I. Rangel, M. Aguado Martin, L. Pedro-Botet, K. Koch, G. Zugazabeitia Irazabal, I. Hausmanowa-Petrusewicz, A. Werther-Evaldsson, A. Korshunova, Q. Zhang, A. Anton Ladislao, C. Bergerot, F. Karlsen, T. Akagi, M. Jasinski, I. Komuro, A. Apor, L. Fourcade, P. Argiento, E. Zemtsovsky, A. Correra, J. Chudek, S. Choi, G. Barletta, A. Varela, A. Manouras, H. Oe, A. D'andrea, S. Ramezani, M. Akil, A. Azevedo, S. Imme, A. Ionac, E. Saracoglu, K. Nakagawa, O. Vinter, S. Reeva, G. Van Camp, T. Forster, T. Butz, I. Ikonomidis, A. Costa, M. Ruiz Lopez, D. Vinereanu, G. Opolski, K. Akay, A. Vrublevsky, J. Silva Marques, L. Sousa, F. D'ascenzi, N. Oprescu, F. Veronesi, A. Mysiak, R. Dan, M. Nobre Menezes, D. Kim, V. Vida, Y. Kim, V. Di Bello, D. Sharif, A. I. Nagy, A. Sikora-Puz, H. Moladoust, C. Florescu, M. Kostrubiec, L. Pierard, E. Ural, A. Goncalves, K. Grudzka, A. Charalampopoulos, A. Luycx-Bore, M. Wilkins, S. Mushtaq, D. Messika-Zeitoun, N. Olsen, C. Mornos, M. Tesic, R. Symons, S. Bekbossynov, H. Erer, M. Kokorina, I. Joao, C. Cotrim, D. Voilliot, M. Yamawaki, N. Roszczyk, J. Inamo, C. Sousa, A. Porto, I. Lekakis, A. G. Caelian, D. Rigopoulos, T. Komori, G. Pontone, S. Scandura, F. Melao, N. Toh, A. Neikova, V. Aboyans, S. La Carrubba, D. Zamfir, S. Dymarkowski, J. Magne, G. Szeplaki, S. Velasco, J. Mcghie, M. Losito, L. Shkolnik, M. Petrovic, I. Papadakis, D. Brito, I. Schilling, O. Bech-Hanssen, M. Enriquez-Sarano, C. Lafaras, O. Enescu, B. Bijnens, R. Lang, C. Lestuzzi, C. Kirma, N. Vallejo, F. Elmkies, M. Vasatova, N. Uslu, M. Yuksel, M. Anastasiou-Nana, G. Gatti, O. Milanesi, V. Donghi, A. Kozuka, C. Henri, K. Tsimopoulou, G. Karakus, A. Cerutti, J. Macancela Quinonez, E. Laraudogoitia, P. Unger, A. Roijer, K. Kurnicka, M. Carasi, D. Djikic, M. Dragovic, H. Aksu, S. Srivatsa, A. Khan, N. Maschietto, D. Cozma, V. Andreakos, C. Meurling, O. Wendler, C. Doulaptsis, E. Aliot, T. Damy, Z. Ojaghihaghighi, L. Mateu, S. Knop, M. Vis, M. Mizia, A. Khalil, E. Abate, M. Gomez Recio, J. Ko, M. Seo, D. Tsiapras, E. Tekbas, C. Celeng, K. Aonuma, M. Przewlocka-Kosmala, S. Laaraibi, T. Sahin, D. Mohty, P. Jorgensen, A. Fiarresga, C. Scharf, E. Conte, V. Pergola, C. Jons, M. Padalino, R. Krecki, M. Malicse, F. Parthenakis, N. Bolivar Herrera, G. Foldes, O. Vriz, J. Kasprzak, S. Janssens, H. Bejiqi, H. Nakajima, R. Naeije, E. Papadavid, A. Subinas, R. Calabro, M. Trbusic, W. Tomkowski, M. Ooshima, A N Vachev, A. Fotaki, E. Brochet, F. Scholz, A. Boshchenko, P. Massoure, S. Munoz Troyano, J. Zumalde, M. Tsakalou, E. Bertella, M. Carminati, A. Kalkan, Y. Miyashita, I. Comanescu, A. M. Esen, K. Nakamura, A. Sanchez Espino, G. Berkenboom, H. Trappe, B. Castaldi, M. Cielecka-Prynda, Y. Otsuji, R. Bejiqi, E. Caiani, A. Moreo, P. Vaida, J. Castillo, S. Stankovic, C. Davos, H. Murata, T. Komiya, K. Berta, A. Aussoleil, A. Yildiz, B. Piamonti, K. Sato, J. Silva-Cardoso, I. Popescu, R. Pap, A. Serafin, K. Addetia, F. Olsen, J. Cautela, C. Yu, R. El Mahmoud, C. Cardoso, N. Echahidi, V. Pyankov, T. Yamada, R. Hoffmann, H. Johno, L. Lopes, R. Li, R. Onut, J. Lekakis, G. Nicolosi, N. Watanabe, Y. Basaran, A. Matos, A. Chmiel, N. Host, M. Sabria, N. Gronkova, P. Hulek, H. Cakmak, E. Wiegerinck, A. Goudev, A. Romero Pereiro, A. Pellegrini, L. Badano, P. Cameli, N. Abdullah, M. Deja, A. Ekmekci, A. Vahanian, A. Retkoceri, V. Mor-Avi, H. Ito, N. Bindraban, T. Rigo, R. Vanderpool, N. Mansencal, M. K. Tigen, J. Bech, H. Thibault, A. Pshepiy, A. Decker-Bellaton, L. Saghy, Z. Al Bulbul, G. Generati, I. Nedeljkovic, Y. Kuatbayev, G. A. Derumeaux, M. Varoudi, Y. Juilliere, K. Uno, P. Virot, B.M. van Dalen, M. Witsenburg, E. Yamashita, K. Okada, E. Gomez, P. Pinto-Teixeira, T. Yambe, N. Preumont, K. Hu, R. Jalalian, A. Formenti, M. Monaghan, P. Pruszczyk, L. Massa, D. Andreini, A. Fromm, E. Stoupel, D. Ural, R. Pilliere, L. Llobera, W. Kim, M. Sobczak, F. Bandera, S. Oliveira, P. Mills, H. Zemir, E. Oner, S. Sparla, C. Cosgrove, S. Kou, A. Annoni, B. Vujisic-Tesic, M. Hojati, L. Carr, P. Meimoun, A. Jaccard, E. Varotto, N. Bulj, T. Kawata, M. Bulut, G. Dimitriadis, B. Ramondo, V. Voudris, H. Christensen, H. Eguchi, J. Grapsa, P. R. Silva Fazendas Adame, C. Cimadevilla, L. Christensen, M. Cikes, A. Izawa, G. Merchan Ortega, A. Makrigiannakis, M. Forkmann, G. Radegran, P. Dias, A. Faiz, C. Stefopoulos, Y. Vasyuk, A. Akyol, L. Howard, A. Correia, J. Younger, and C. Greis

Subjects
medicine.medical_specialty, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2013
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23. PO009 Prediction of Atrial Fibrillation Recurrence After Catheter Ablation, By Interatrial Conduction Time Assessed With Tissue Doppler Imaging

Author

D. Rasic, M. Marinkovic, D. Djikic, Aleksandar Kocijancic, D.V. Simic, V. Peric, V. Kovacevic, Nebojsa Mujovic, S. Lazic, Marija Polovina, and O. Bojana

Subjects
Community and Home Care, medicine.medical_specialty, Epidemiology, business.industry, medicine.medical_treatment, Catheter ablation, Atrial fibrillation, medicine.disease, Doppler imaging, Interatrial conduction, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Published
2018
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24. The Relevance of Pharmacokinetic Studies in Designing Efficacy Trials in Juvenile Major Depression

Author

Robert L. Findling, Eric A. Youngstrom, Christopher M. Young, Robert J. Stansbrey, Franco V. Peric, Nora K. McNamara, and Norah C. Feeny

Subjects
Depressive Disorder, Major, medicine.medical_specialty, Sertraline, Fluoxetine, Adolescent, Dose-Response Relationship, Drug, Venlafaxine, Citalopram, Antidepressive Agents, Psychiatry and Mental health, Tolerability, Research Design, Pediatrics, Perinatology and Child Health, medicine, Humans, Escitalopram, Pharmacology (medical), Dosing, Child, Psychiatry, Intensive care medicine, Psychology, Nefazodone, Randomized Controlled Trials as Topic, medicine.drug
Abstract

Identifying evidence-based dosing strategies is a key part of new drug development in pediatric populations. Pharmacokinetic (PK) studies can provide important information regarding how best to dose medications in children and adolescents. Utilizing scientifically supported dosing strategies provides the best chance for any given drug to demonstrate both efficacy and acceptable tolerability in definitive, placebo-controlled studies.Results of both PK studies and randomized, placebo-controlled efficacy trials (RPCTs) in juvenile major depressive disorder (MDD) are reviewed. The degree to which the medication dosing strategies that were employed in the efficacy studies were supported by the extant PK data is considered. Medications that are reviewed include fluoxetine, sertraline, paroxetine, citalopram, escitalopram, venlafaxine, nefazodone, and mirtazapine.In many instances, the dosing paradigms that were used in the RPCTs differed, sometimes substantially, from the dosing strategies that would have been supported based on the results of PK studies.Medication dosing regimens may have contributed to the failure of several RPCTs to show drug efficacy in the treatment of pediatric MDD. In addition, the doses of medication used in these RPCTs may also have contributed to the safety and tolerability concerns that have been raised with these drugs. PK and dose-ranging studies should be performed prior to the initiation of definitive efficacy trials so that empirically supported dosing strategies can be incorporated into the design of RPCTs of antidepressants in children and adolescents suffering from MDD.

Published
2006
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25. Examination of some functional properties of silver carp (hypophthalmichthys molitrix val) and carp (cyprinus carpio lin) meat

Author

N Marija Perunovic, D. Zivkovic, and V. Peric

Subjects
water binding ability, Soil Science, Plant Science, Cyprinus, lcsh:Agriculture, gelling ability (module of elasticity), silver carp meat, Food science, Carp, held water, Silver carp, Hypophthalmichthys, biology, business.industry, lcsh:S, food and beverages, biology.organism_classification, Biotechnology, carp meat, Poultry meat, %22">Fish , Animal Science and Zoology, sense organs, Water binding, business, Agronomy and Crop Science
Abstract

Water binding ability (WBA), held water (HW) and gel-forming properties of silver carp (Hypophthalmichthys molitrix Val) and carp (Cyprinus carpio Lin) meat were examined in this paper. Two variants of fish meat gels: A with 50% of meat and B with 60% of meat were examined at temperatures: 70 75, 80, 85 and 90 oC. The variant A of silver carp meat gels has shown the maximum of WBA and HW at 80 oC, and the variant B at 75 oC. In both variants of carp meat gels slow increase of WBA and HW with rise of temperature to 80oC was established. Silver carp meat gels have had better WBA than control gels (beef and poultry meat), and carp meat gels have better HW, but somewhat worse WBA than control gels. In gels of variant A of silver carp meat the highest module of elasticity (6.862 N/cm2) was found at thermal treatment at 85 oC, but statistically significant differences in relation to other temperatures were not established. In variant B, with the rise of temperature, the module of elasticity increases; statistically significant differences were established among gels treated at 70 oC and others. Differences between variants A and B were statistically significant at all examined temperatures. Meat gels of silver carp have significantly lower module of elasticity compared to control gels. Under conditions of our experiment the module of elasticity of carp meat was below measuring limit.

Published
2004
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26. Cortical Dysgeneses as Inducement of Epilepsy

Author

V. Peric, T. Stosic-Opincal, and N. Jovic

Subjects
Epilepsy, Radiological and Ultrasound Technology, business.industry, Cortical dysgenesis, medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Malformation of cortical development, medicine.disease, business, Neuroscience
Published
2003
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27. Intraventricular Textiloma with Granuloma Formation Following Third Ventricle Colloid Cyst Resection – A Case Report

Author

M. Gavrilov, Tatjana Stosic-Opincal, V. Peric, S. Gavrilovic, D. Cvetkovic-Dozic, S. Lavrnic, D. Grujicic, and R. Milenkovic

Subjects
Surgical Sponges, medicine.medical_specialty, Dissection (medical), Asymptomatic, Third Ventricle Colloid Cyst, Neuroimaging, medicine, Humans, Cotton Fiber, Central Nervous System Cysts, Abscess, Third Ventricle, Third ventricle, medicine.diagnostic_test, Brain Neoplasms, business.industry, Granuloma, Foreign-Body, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Hemostasis, Surgical, Surgery, medicine.anatomical_structure, Granuloma, Female, Radiology, medicine.symptom, business
Abstract

Despite precautions, cotton and gauze pads used for dissection or to achieve haemostasis during neurosurgical procedures can inadvertently be left behind and result in clinically symptomatic or asymptomatic and radiologically apparent mass lesion, sometimes referred to as "textilomas" or "gossypibomas", often mimicking recurrent tumour or abscess on neuroimaging studies. We report the neuroimaging evaluation, including computed tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (H1-MRS), in a case of textiloma developing after the treatment of a third ventricle colloid cyst.

Published
2009
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28. Komparacija detektabilnosti mozdanih lezija u multipleks sklerozi pri pregledu magnetnom rezonancijom jacine magnetnog polja 1.0 i 3.0 Tesla

Author

M. Jovancevic, S. Gavrilovic, R. Milenkovic, Tatjana Stosic-Opincal, S. Lavrnic, V. Peric, and M. Gavrilov

Subjects
medicine.diagnostic_test, business.industry, media_common.quotation_subject, Multiple sclerosis, Magnetic resonance imaging, General Medicine, Fluid-attenuated inversion recovery, medicine.disease, medicine, Spin echo, Contrast (vision), Brain lesions, Tomography, Nuclear medicine, business, Neuroradiology, media_common
Abstract

To estimate the relative sensitivity of MR examination for brain lesions in multiple sclerosis at 1.0 Tesla (T) and 3.0 T using identical acquisition conditions. 54 patients with multiple sclerosis were examined both at 1.0T (Siemens Impact Expert) and 3.0T (Philips Intera) using T1-weighted spin echo (T1W-SE) with and without gadolinium contrast injections, T2W SE and fluid attenuated inversion recovery (FLAIR) imaging. Images were examined independently by three experienced neuroradiologists using focal lesion counting. 3.0T scans compared with 1.0T scans demonstrate a 27.3%, increase in the number of detected contrast enhanced lesions and an 22.7% increase in the number of detected lesions on FLAIR MR tomograms. High field 3.0T MR imaging demonstrates better sensitivity in the detection of focal brain lesions in multiple sclerosis. This improvement is more apparent in contrast enhanced lesion detection and less noticeable in FLAIR detected lesions.

Published
2007
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29. Inhalation plus intravenous colistin versus intravenous colistin alone for treatment of ventilator associated pneumonia

Author

Bogović TZ, Baronica R, Tomasevic B, Miric M, Drvar Z, Pavlek M, Bratic V, Peric M, Budimir A, Bosnjak z, Hrabac P.

Subjects
ventilator-associated
Abstract

In the setting of intensive care units the incidences of multi-drug resistant gram-negative (MDR-GN) pathogens causing ventilator associated pneumonia (VAP) has increased, leading clinicians to use colistin. Our aim was to assess outcomes associated with the use of inhalation and intravenous colisitn versus only intravenous colistin in patients with MDR-GN VAP. A retrospective, single centre study at University Hospital Centre, Zagreb. Patients were divided in two groups, according to their administration of antibiotics – inhalation and intravenous (INH+IV) administration for 8 patients or intravenous only (IV) administration for 23 patients. The results showed that demographic and clinical characteristics and the gram negative pathogens isolated were similar between the two groups, except for K. pneumoniae, which was higher in the IV group. No statistically significant difference between the two groups were observed regarding intensive care unit mortality (P=0.951), sepsis (P=0.474), acute respiratory distress syndrome (P=0.548), length of ICU stay (P=0.686) and length of mechanical ventilation (P=0.858). A statistically significant difference was found regarding the eradication of pathogens in respiratory cultures (P= 0.018). The addition of inhalation to intravenous colistin in MDR-GN VAP improves microbiologic outcome, but does not improve ICU mortality in these patients. Larger prospective trials are warranted to confirm the benefit of adjunctive inhalation colistin as a MDR-GN VAP therapy in the critically ill.

Published
2014

30. Clinical and echocardiographic differences in patients with dilated cardiomyopathy in the frame depending preserved left ventricular contractile reserve

Author

V Peric and Petar Otasevic

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Ejection fraction, Wall motion score index, business.industry, Dilated cardiomyopathy, General Medicine, medicine.disease, Cardiac surgery, Internal medicine, Poster Presentation, cardiovascular system, medicine, Cardiology, Ventricular volume, Surgery, In patient, cardiovascular diseases, Cardiology and Cardiovascular Medicine, business
Abstract

displacement measured by tissue Doppler (6.02 ± 1.67 vs. 4.88 ± 1.26 cm/s, p = 0.006), smaller end-diastolic (70.94 ± 24.45 vs. 94.92 ± 33.13 ml/m2, p

Published
2013
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31. Poster Session 4The imaging examination and quality assessmentP957Economic impact analysis and quality performance of working with cardiovascular sonographers in high-volume echocardiography laboratoryP958Feasibility of temporal super resolution enhancement of echocardiographic images to diagnose cardiac DiseasesP959Remote medical diagnostician project - Achievements and limitation in tele-echocardiographyP960Right atrial remodeling and galectin-3 are associated with functional capacity in patients with pulmonary arterial hypertensionP961Interatrial electromechanical delay assessed by tissue doppler imaging can separate adults with prehypertension from healthy normotensive controlsP962Preliminary results of an extensive echocardiographic pacemaker optimization protocol for cardiac resynchronization therapyP963Left ventricular global and regional myocardial function in patients with double orifice mitral valve after radical correction on atrioventricular septal defectP964Improving quantitation of left ventricular ejection fraction in a tertiary echocardiography lab - marrying (or merging) guidelines and new technologyP965Echocardiographic evaluation of cardiac function and hemodynamics during LVAD-based resuscitation from cardiac arrest - a porcine studyP966Systolic excursion of the right ventricular outflow tract as a marker of right ventricular dysfunctionP967The impact of the new 2016 ASE/EACVI recommendations in the prevalence and grades of diastolic dysfunction: an analysis from the general populationP968Differential microRNA-21 and microRNA-133 gene expression levels in peripheral blood mononuclear cells from patients with heart failure with preserved ejection fractionP969CMR evaluation of cardiac thrombi and masses by T1 and T2 mapping : an observational studyP970Effect of coronary artery ectasia on left ventricular deformation mechanics. A 2D Speckle Tracking Echocardiography studyP971Diagnostic performance of stress Echo, SPECT, PET, stress CMR, CTCA, CTP and FFRCT for the assessment of CAD versus invasive FFR: a metaanalysisP972Utility of early assessment of myocardial mechanics in STEMI patients treated by primary percutaneous coronary intervention to predict major adverse cardiac events during the first 12 months of folloP973Role of left atrial reservoir in the prediction of increased left ventricular filling pressures in patients with ST-segment elevation myocardial infarctionP974Does the left ventricle ejection fraction improves the Grace risk score accuracy? P975Can we predict significant coronary stenosis using regional strain analysis in non-ST elevation acute coronary syndrome?P976Persistence of pulmonary hypertension after transcatheter aortic valve replacement: incidence and prognostic impactP977Global longitudinal strain is an independent predictor of all cause mortality in patients with severe aortic valve stenosis undergoing valve replacement or treated conservativallyP978Contribution of left ventricular diastolic dysfunction and myocardial fibrosis to pulmonary hypertension in severe aortic stenosisP979Left atrial dysfunction as a determinant of pulmonary hypertension in patients with isolated severe aortic stenosis and preserved left ventricular ejection fractionP980Intraprocedural monitoring protocol using routine transthoracic echocardiography with backup transesophageal probe in transcatheter aortic valve replacement: a single center experience

Author

S. Stella, AD. Mateescu, A. Krivickiene, B. Fries, M. Drakopoulou, D. Lovric, M. Madeira, M. Cusma Piccione, D. Trifunovic, G. Pontone, N. Kouris, T. Caspar, M. Marketou, J. Almeida, TM. Crowe, R. Zayat, D. Erne, K. Hristova, P. Barbier, D. Djikic, L. Gabrielli, D. Szczesniak-Stanczyk, S. Ranjbar, B. De Chiara, F. Casadei, A. Peritore, F. Spano, G. Santambrogio, M. Vicario, I. Trolese, C. Gallina, C. Giannattasio, A. Moreo, M. Karvandi, LP. Badano, W. Brzozowski, R. Blaszczyk, M. Szyszko, R. Zarczuk, M. Janowski, A. Wysokinski, B. Stanczyk, M. Sitges, P. Castro, H. Verdejo, MP. Ocaranza, P. Sepulveda, S. Llevaneras, F. Baraona, M. Salinas, S. Lavanderos, N. Mujovic, B. Dejanovic, V. Peric, M. Marinkovic, N. Jankovic, B. Orbovic, D. Simic, M. Guglielmo, L. Salvini, G. Savioli, A. Dasheva, R. Marinov, S. Lasarov, I. Mitev, P. M, K. Rhodes, M. Bartlett, A. Chong, S. Wahi, M. Derwall, A. Ebeling, C. Nix, G. Marx, R. Autschbach, N. Hatam, P. Sonecki, MJ. Brewis, AC. Church, MK. Johnson, AJ. Peacock, R. Fontes-Carvalho, F. Sampaio, J. Ribeiro, P. Bettencourt, A. Leite-Moreira, A. Azevedo, J. Kontaraki, P. Parthenakis, S. Maragkoudakis, M. Touloupaki, A. Patrianakos, J. Konstantinou, M. Vernardos, J. Logakis, P. Vardas, S. El Ghannudi, P. Ohlmann, A. Lawson, O. Morel, M. Ohana, C. Roy, A. Gangi, P. Germain, P. Kostakou, A. Dagre, E. Trifou, I. Rodis, V. Kostopoulos, CD. Olympios, AI. Guaricci, M. Verdecchia, D. Andreini, A. Baggiano, V. Beltrama, G. Ferro, P. Carita', M. Pepi, G. Krljanac, L. Savic, M. Asanin, D. Matovic, J. Stepanovic, G. Stankovic, I. Mrdovic, A. Terrizzi, O. Trio, A. Oteri, G. D'amico, A. Ioppolo, G. Nucifora, M. Zucco, M. Sergi, A. Nicotera, I. Boretti, S. Carerj, C. Zito, R. Teixeira, L. Reis, P. Dinis, A. Fernandes, F. Caetano, I. Almeida, M. Costa, L. Goncalves, V. Reskovic Luksic, Z. Baricevic, D. Dosen, M. Pasalic, Z. Ostojic, M. Brestovac, J. Bulum, J. Separovic Hanzevacki, K. Toutouzas, K. Stathogiannis, A. Michelongona, G. Latsios, A. Synetos, G. Trantalis, O. Kaitozis, S. Brili, D. Tousoulis, D. Liu, K. Hu, W. Voelker, G. Ertl, F. Weidemann, S. Herrmann, B. Gumauskiene, E. Drebickaite, E. Ereminiene, JJ. Vaskelyte, A. Calin, M. Rosca, CC. Beladan, R. Enache, C. Calin, I. Cosei, S. Botezatu, M. Simion, C. Ginghina, BA. Popescu, I. Rosa, C. Marini, F. Ancona, A. Latib, M. Monitorano, A. Colombo, A. Margonato, and E. Agricola

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2016
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32. Poster Session 3The imaging examination and quality assessmentP626Value of mitral and tricuspid annular displacement to assess the interventricular systolic relationship in severe aortic valve stenosis : a Pilot studyP627Follow-up echocardiography in asymptomatic valve disease: assessing the potential economic impact of the European and American guidelines in a dedicated valve clinic, compared to standard care.P628The tricuspid valve: identification of optimal view for assessing for prolapseP629Right atrial volume by two-dimensional echocardiography in healthy subjectsP630Disturbance of inter and intra atrial conduction assessed by tissue doppler imaging in patients with medicaly controlled hypertension and prehypertension.P631Liver stiffness by shear wave elastography, new noninvasive and quantitative tool for acute variation estimation of central venous pressure in real-time?P632Weak atrial kick contribution is associated with a risk for heart failure decompensationP633Usefulness of wave intensity analysis in predicting the response to cardiac resynchronization therapyP634Early subclinical left ventricular systolic and diastolic dysfunction in gestational hypertension and preeclampsiaP635Clinical comparison of three different echocardiographic methods for left ventricular ejection fraction and LV end diastolic volume measurementP636Assessment of right ventricular-arterial coupling parameters by 3D echocardiography in patients with pulmonary hypertension receiving specific vasodilator therapyP637Prediction of right ventricular failure after left ventricular assist device implant: assessing usefulness of standard and strain echocardiographyP638Kinematic analysis of diastolic function using the novel freely available software Echo E-waves - feasibility and reproducibilityP639Evaluation of coronary flow velocity by Doppler echocardiography in the treatment of hypertension with the ARB: correlation to the histological cardiac fibrosisP640The clinical significance of limited apical ischaemia and the prognostic value of stress echocardiography - A contemporary study from a high volume centerP641Effects of intermediate stenosis of left anterior descending coronary artery on survival in patients with chronic total occlusion of right coronary arteryP642Left ventricular remodeling after a first myocardial infarction in patients with preserved ejection fraction at dischargeP643Left atrial size and acute coronary syndromes. Let is make simple.P644Influence of STEMI reperfusion strategy on systolic and diastolic functionP645Aortic valve resistance risk-stratifies low-gradient severe aortic stenosisP646Does permanent pacemaker implantation complicate the prognosis of patients after transcatheter aortic valve implantation?P647Influence of metabolic syndrome and diabetes on progression of calcific aortic valve stenosis - The COFRASA - GENERAC StudyP648Low referral for aortic valve replacement accounts for worse long-term outcome in low versus high gradient severe aortic stenosis with preserved ejection fractionP649The impact of right ventricular function from aortic valve replacement: A randomised study comparing minimally invasive aortic valve surgery and conventional open heart surgery

Author

N. Hashemi, YJ. Mo, A. Testuz, M. D'angelo, H. Nishikawa, J. Nieto Tolosa, L. Reis, C. Volpi, A. Djordjevic-Dikic, A. Papachristidis, C. Wei-Ting, M. Sundqvist, DB. Diego Bellavia, E. Popa, N. Benyounes, N. Patrascu, K. Niki, L. Takahashi, O. Villemain, D. Djikic, F. Ferrara, NK. Preston, DNS Senaratne, T. Ota, K. Toyota, K. Nagamine, Y. Koide, T. Nomura, J. Kurata, Y. Murakami, Y. Kozuka, C. Ohshiro, K. Thomas, C. Townsend, S. Wheeler, I. Jacobson, A. Elkington, K. Balkhausen, S. Bull, L. Ring, L. Gargani, L. Carannante, V. Russo, M. D'alto, AM. Marra, A. Cittadini, A. D'andrea, O. Vriz, E. Bossone, N. Mujovic, B. Dejanovic, V. Peric, M. Marinkovic, N. Jankovic, B. Orbovic, D. Simic, F. Sitefane, M. Pernot, G. Malekzadeh-Milani, J. Baranger, D. Bonnet, Y. Boudjemline, T. Uejima, H. Semba, H. Sawada, T. Yamashita, M. Sugawara, H. Kayanuma, K. Inoue, M. Yagawa, I. Takamisawa, J. Umemura, T. Yoshikawa, H. Tomoike, DJ. Mihalcea, S. Mihaila, L. Lungeanu, LF. Trasca, R. Bruja, MS. Neagu, S. Albu, M. Cirstoiu, D. Vinereanu, C. Van Der Vynckt, O. Gout, A. Cohen, R. Enache, R. Jurcut, IM. Coman, R. Badea, P. Platon, A. Calin, CC. Beladan, M. Rosca, C. Ginghina, BA. Popescu, SD. Sonia Dell'oglio, AI. Attilio Iacovoni, CF. Calogero Falletta, GR. Giuseppe Romano, SS. Sergio Sciacca, LS. Lissa Sugeng, JM. Joseph Maalouf, MP. Michele Pilato, MS. Michele Senni, CS. Cesare Scardulla, FC. Francesco Clemenza, K. Salman, P. Tornvall, M. Ugander, ZC. Chen, JJ. Wang, S. Fisch, RL. Liao, D. Roper, D. Casar Demarco, M. Papitsas, I. Tsironis, J. Byrne, K. Alfakih, MJ. Monaghan, N. Boskovic, I. Rakocevic, V. Giga, M. Tesic, J. Stepanovic, I. Nedeljkovic, S. Aleksandric, J. Kostic, B. Beleslin, M. Altman, MS. Annabi, L. Abouchakra, U. Cucchini, D. Muraru, LP. Badano, L. Ernande, G. Derumeaux, R. Teixeira, A. Fernandes, I. Almeida, P. Dinis, M. Madeira, J. Ribeiro, L. Puga, J. Nascimento, L. Goncalves, FJ. Cambronero Sanchez, E. Pinar Bermudez, JR. Gimeno Blanes, G. De La Morena Valenzuela, T. Lopez Fernandez, FJ. Irazusta Cordoba, SO. Rosillo Rodriguez, FJ. Dominguez Melcon, P. Meras Colunga, D. Gemma, R. Moreno Gomez, M. Moreno Yanguela, JL. Lopez Sendon, V. Nguyen, T. Mathieu, C. Kerneis, C. Cimadevilla, N. Kubota, I. Codogno, S. Tubiana, C. Estrellat, A. Vahanian, D. Messika-Zeitoun, T. Ondrus, G. Van Camp, G. Di Gioia, E. Barbato, J. Bartunek, M. Penicka, J. Johnsson, A. Gomez, M. Alam, and R. Winter

Subjects
Pathology, medicine.medical_specialty, business.industry, General Medicine, Aneurysm dissecting, medicine.artery, Ascending aorta, Medicine, Thoracic aorta, Radiology, Nuclear Medicine and imaging, Gene polymorphism, Cardiology and Cardiovascular Medicine, business, Fibrillin
Published
2016
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33. Nutrition parameters as hemodialysis adequacy markers

Author

R, Stolic, G, Trajkovic, D, Stolic, V, Peric, and G, Subaric-Gorgieva

Subjects
Original Article
Abstract

The nutritive status has significant role in improving the quality of life of dialysis' patients. The aim of this study was to find out if there is any correlation of the anthropometric parameters and markers of nutrition with the adequacy of HD.The investigation was organized as a clinical, cross sectional study. Demographic characteristics, co-morbid conditions, smoking, dialysis duration and blood pressure were recorded. Serum total protein, albumin, ferritin and blood-lipids were measured as biochemical markers of nutritional status.One hundred and forty patients, 82 (58.6%) male, and 58 (41.4%) female, 55±12.59 years, were dividied into two groups. Group A consisted of 44 patients (14 women and 30 men) received the recommended hemodialysis dose (Kt/V ≥ 1.2), while the Group B consisted of 96 patients (69 males and 27 females) received non-adequate hemodialysis dose (Kt/V1.2).Patients with adequate hemodialysis had been longer on dialysis in correlation with the group of patients with non-adequate hemodialysis (73 ± 56.4 vs. 44 ± 50.1 months; p: 0.004). Group A and group B presented significant differences in the number of leukocytes (p: 0.027), and hemoglobin (p: 0.047), potassium (p: 0.038) and C-reactive protein level (p: 0.048) as well as in serum total protein (69 ± 4.63 vs. 65 ± 5.74 g/L; p0.0001) and albumin (38 ± 2.99 vs. 29 ± 4.4 g/L; p: 0.047). Pearsons correlation of factors that may have impact on hemodialysis adequacy indicated a significant relation between serum total protein and the index of hemodialysis adequacy (r: 0.21; p: 0.0446).All investigated anthropometric parameters and protein status showed significantly higher values in patients with adequate hemodialysis quality (Group A). The Group B showed higher levels of CRP and lower values of hemoglobin.

Published
2010

34. Papillary glioneuronal tumor

Author

Z Markovic, R. N. Sener, M. Gavrilov, Tatjana Stosic-Opincal, S. Gavrilovic, and V. Peric

Subjects
medicine.medical_specialty, Pathology, Adolescent, Brain tumor, Optic papilla, 03 medical and health sciences, 0302 clinical medicine, Glioneuronal tumor, medicine, Carcinoma, Humans, Radiology, Nuclear Medicine and imaging, Ganglioglioma, business.industry, Brain Neoplasms, General Medicine, medicine.disease, University hospital, Magnetic Resonance Imaging, Carcinoma, Papillary, 3. Good health, 030220 oncology & carcinogenesis, Papillary glioneuronal tumor, Histopathology, Female, business, 030217 neurology & neurosurgery
Abstract

2Department of Radiology, Ege University Hospital, Bornova, Izmir 35100, Turkey. Address correspondence to R. N. Sener (rnsener@med.ege.edu.tr). ecent advances in brain tumor characterization by histopathology have resulted in the discovery of tumors with neuronal elements including subtypes of gangliogliomas such as the rosette glioneuronal tumor and papillary glioneuronal tumor [1–11]. Papillary glioneuronal tumors have been reported in 17 patients in pathology journals [1–9]. In this article, we report another case of papillary glioneuronal tumor.

Published
2005

35. Comparative analysis of the SOL plasma in DEMO using EDGE2D/EIRENE and TECXY codes

Author

G. Rubino, R. Ambrosino, G. Calabrò, V. Pericoli Ridolfini, and B. Viola

Subjects
Nuclear engineering. Atomic power, TK9001-9401
Abstract

In this contribution a benchmark of the 2D edge codes TECXY and EDGE2D-EIRENE is presented. A conventional DEMO scenario is considered by assuming a simplified geometry, with the target plates perpendicular to the separatrix, and a pure Deuterium plasma. Despite the different models adopted in the two codes, mainly related to the description of the neutral dynamics and to the different boundary conditions, the results show a good match both in terms of power load profiles on the outer target and predicted trends for global quantities. A scan in density and in diffusion coefficients is performed in order to identify the characteristic conditions and the different regimes of the SOL. Comparable values and similar dependency of the global quantities as a function of the power decay length is also observed. Keywords: EDGE2D, EIRENE, TECXY, DEMO, Divertor

Published
2017
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36. Preliminary analysis of the efficiency of non-standard divertor configurations in DEMO

Author

F. Subba, L. Aho-Mantila, R. Ambrosino, D.P. Coster, V. Pericoli-Ridolfini, A. Uccello, and R. Zanino

Subjects
Nuclear engineering. Atomic power, TK9001-9401
Abstract

The standard Single Null (SN) divertor is currently expected to be installed in DEMO. However, a number of alternative configurations are being evaluated in parallel as backup solutions, in case the standard divertor does not extrapolate successfully from ITER to a fusion power plant. We used the SOLPS code to produce a preliminary analysis of two such configurations, the X-Divertor (XD) and the Super X-Divertor (SX), and compare them to the SN solution. Considering the nominal power flowing into the SOL (PSOL = 150 MW), we estimated the amplitude of the acceptable DEMO operational space. The acceptability criterion was chosen as plasma temperature at the target lower than 5eV, providing low sputtering and at least partial detachment, while the operational space was defined in terms of the electron density at the outboard mid-plane separatrix and of the seeded impurity (Ar only in the present study) concentration. It was found that both the XD and the SXD extend the DEMO operational space, although the advantages detected so far are not dramatic. The most promising configuration seems to be the XD, which can produce acceptable target temperatures at moderate outboard mid-plane electron density (nomp=4.5×1019 m−3) and Zeff= 1.3. Keywords: DEMO, Advanced divertor, Numerical modeling, Detachment

Published
2017
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37. Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer.

Author

Toner YC, Prévot G, van Leent MMT, Munitz J, Oosterwijk R, Verschuur AVD, van Elsas Y, Peric V, Maas RJF, Ranzenigo A, Morla-Folch J, Wang W, Umali M, de Dreu A, Fernandes JC, Sullivan NAT, Maier A, Mason C, Reiner T, Fayad ZA, Mulder WJM, Teunissen AJP, and Pérez-Medina C

Abstract

Macrophages are key inflammatory mediators in many pathological conditions, including cardiovascular disease (CVD) and cancer, the leading causes of morbidity and mortality worldwide. This makes macrophage burden a valuable diagnostic marker and several strategies to monitor these cells have been reported. However, such strategies are often high-priced, non-specific, invasive, and/or not quantitative. Here, we developed a positron emission tomography (PET) radiotracer based on apolipoprotein A1 (ApoA1), the main protein component of high-density lipoprotein (HDL), which has an inherent affinity for macrophages. We radiolabeled an ApoA1-mimetic peptide (mA1) with zirconium-89 ( 89 Zr) to generate a lipoprotein-avid PET probe ( 89 Zr-mA1). We first characterized 89 Zr-mA1's affinity for lipoproteins in vitro by size exclusion chromatography. To study 89 Zr-mA1's in vivo behavior and interaction with endogenous lipoproteins, we performed extensive studies in wildtype C57BL/6 and Apoe -/- hypercholesterolemic mice. Subsequently, we used in vivo PET imaging to study macrophages in melanoma and myocardial infarction using mouse models. The tracer's cell specificity was assessed by histology and mass cytometry (CyTOF). Our data show that 89 Zr-mA1 associates with lipoproteins in vitro. This is in line with our in vivo experiments, in which we observed longer 89 Zr-mA1 circulation times in hypercholesterolemic mice compared to C57BL/6 controls. 89 Zr-mA1 displayed a tissue distribution profile similar to ApoA1 and HDL, with high kidney and liver uptake as well as substantial signal in the bone marrow and spleen. The tracer also accumulated in tumors of melanoma-bearing mice and in the ischemic myocardium of infarcted animals. In these sites, CyTOF analyses revealed that nat Zr-mA1 was predominantly taken up by macrophages. Our results demonstrate that 89 Zr-mA1 associates with lipoproteins and hence accumulates in macrophages in vivo. 89 Zr-mA1's high uptake in these cells makes it a promising radiotracer for non-invasively and quantitatively studying conditions characterized by marked changes in macrophage burden., Competing Interests: Competing interestsW.J.M.M. is a founder and CSO of Trained Therapeutix Discovery. Z.A.F. is a founder and member of the board of Trained Therapeutix Discovery. T.R. is now an employee of and shareholder in Novartis AG. No other potential financial or non-financial conflicts of interest relevant to this article exist., (© The Author(s) 2024.)

Published
2024
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38. In silico development of potential therapeutic for the pain treatment by inhibiting voltage-gated sodium channel 1.7.

Author

Golubovic M, Kostic T, Djordjevic M, Peric V, Lazarevic M, Milic DJ, Marjanovic V, and Veselinović AM

Subjects
Computer Simulation, Humans, Molecular Docking Simulation, NAV1.7 Voltage-Gated Sodium Channel, Pain, Quantitative Structure-Activity Relationship, Voltage-Gated Sodium Channels
Abstract

The voltage-gated sodium channel Nav1.7 can be considered as a promising target for the treatment of pain. This research presents conformational-independent and 3D field-based QSAR modeling for a series of aryl sulfonamide acting as Nav1.7 inhibitors. As descriptors used for building conformation-independent QSAR models, SMILES notation and local invariants of the molecular graph were used with the Monte Carlo optimization method as a model developer. Different statistical methods, including the index of ideality of correlation, were used to test the quality of the developed models, robustness and predictability and obtained results were good. Obtained results indicate that there is a very good correlation between 3D QSAR and conformation-independent models. Molecular fragments that account for the increase/decrease of a studied activity were defined and used for the computer-aided design of new compounds as potential analgesics. The final evaluation of the developed QSAR models and designed inhibitors were carried out using molecular docking studies, bringing to light an excellent correlation with the QSAR modeling results., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
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39. Cost Analysis of Health Examination Screening Program for Ischemic Heart Disease in Active-Duty Military Personnel in the Middle-Income Country.

Author

Simic R, Ratkovic N, Dragojevic Simic V, Savkovic Z, Jakovljevic M, Peric V, Pandrc M, and Rancic N

Subjects
Aged, Costs and Cost Analysis, Humans, Male, Retrospective Studies, Serbia, Military Personnel, Myocardial Ischemia diagnosis
Abstract

Cardiovascular diseases, including ischemic heart disease, are the most common causes of morbidity and death in the world, including Serbia, as a middle-income European country. The aim of the study was to determine the costs of preventive examinations for ischemic heart disease in active-duty military personnel, as well as to assess whether this was justified from the point of view of the limited health resources allocated for the treatment of the Republic of Serbia population. This is a retrospective cost-preventive study which included 738 male active-duty military personnel, aged from 23 to 58. The costs of primary prevention of ischemic heart disease in this population were investigated. Out of 738 subjects examined, arterial hypertension was detected in 101 subjects (in 74 of them, arterial hypertension was registered for the first time, while 27 subjects were already subjected to pharmacotherapy for arterial hypertension). Average costs of all services during the periodic-health-examination screening program were €76.96 per subject. However, average costs of all services during the periodic-health-examination screening program for patients with newfound arterial hypertension and poorly regulated arterial hypertension were €767.54 per patient and €2,103.63 per patient, respectively. Since periodic-health-examination screening program in military personnel enabled not only discovery of patient with newfound arterial hypertension but also regular monitoring of those who are already on antihypertensive therapy, significant savings of €690.58 per patient and €2,026.67 per patient can be achieved, respectively. As financial resources for providing health care in Serbia, as a middle-income country, are limited, further efforts should be put on screening programs for ischemic heart disease due to possible significant savings., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Simic, Ratkovic, Dragojevic Simic, Savkovic, Jakovljevic, Peric, Pandrc and Rancic.)

Published
2021
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40. The routine use of platelet function tests in elective coronary artery bypass grafting: A prospective observational trial.

Author

Matkovic M, Novakovic T, Bilbija I, Lazovic JM, Tutus V, Cubrilo M, Aleksic N, Mikic A, Petrovic E, Peric V, Milojevic A, and Putnik S

Subjects
Blood Platelets, Coronary Artery Bypass, Humans, Platelet Aggregation, Postoperative Hemorrhage epidemiology, Platelet Aggregation Inhibitors, Platelet Function Tests
Abstract

Background: Preoperative use of platelet function tests contributes to the decrease of re-intervention rate due to bleeding and the necessity of transfusion in coronary artery bypass grafting (CABG) patients. The aim was to investigate the predictive value and to justify routine preoperative use of multiple electrode aggregometry in these patients., Methods: A prospective observational trial which included 416 consecutive patients subjected to elective isolated CABG was conducted. The Multiplate® test was used to assess platelet function. Platelet function test results, postoperative blood loss, and transfusion requirements were compared between high and low bleeding risk patients. Receiver operating characteristic analysis was performed to assess the sensitivity and specificity of the arachidonic acid (ASPI) and adenosine di-phosphate high sensitive (ADPHS) tests., Results: ADPHS and ASPI test results significantly predicted total bleeding > 1000 ml (AUC, 0.685, p < .001; 0.695, p = .039). Sensitivity and specificity were 62.9% and 40.0%, for ADPHS ≤602, and 70.8% and 41.8%, for ASPI ≤ 453. The sensitivity and specificity of cut-off values recommended by the manufacturer were 84.2% and 40.0% for ADPHS ≤ 500, while for ASPI < 600 the values were 54.7% and 62.2%. More platelets and cryoprecipitate were transfused in patients with ADPHS ≤ 602.5 (p < .001; p = .035). Patients with ADPHS ≤ 500 had a higher rate of red blood count, platelet and cryoprecipitate transfusion (p<.001p<.001; p = .013). The manufacturer's ASPI test cut-off values showed no statistically significant prediction for a higher transfusion rate., Conclusion: Preoperative platelet function tests should be conducted systematically for all elective CABG patients who were on dual antiplatelet therapy after adjusting test cut-off values for each population., (© 2021 Wiley Periodicals LLC.)

Published
2021
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41. Potential New Approaches in Predicting Adverse Cardiac Events One Month after Major Vascular Surgery.

Author

Golubovic M, Peric V, Stanojevic D, Lazarevic M, Jovanovic N, Ilic N, Djordjevic M, Kostic T, and Milic D

Subjects
Aged, Aged, 80 and over, C-Reactive Protein analysis, Creatine Kinase, MB Form blood, Female, Heart Diseases surgery, Humans, Male, Middle Aged, Natriuretic Peptide, Brain blood, ROC Curve, Risk Factors, Serbia epidemiology, Time, Troponin I blood, Biomarkers blood, Heart Diseases epidemiology, Risk Assessment methods, Vascular Surgical Procedures
Abstract

Objective: The aim of our study was to find the best model with sufficient power to improve the risk stratification in major vascular surgery patients during the first 30 days after this procedure. The discriminatory power of 4 biomarkers (troponin I [TnI], N-terminal prohormone of brain natriuretic peptide [NT-proBNP], creatine kinase-MB isoenzyme [CK-MB], high-sensitivity C-reactive protein [hs-CRP]) was tested as well as 2 risk assessment models and 13 different combinations of them., Subjects and Methods: The study included 122 patients (77% men, 23% women) with an average age of 67.03 ± 4.5 years. An aortobifemoral bypass was performed in 6.56% of the patients, a femoropopliteal bypass in 18.85%, and 49.18% received open surgical reconstruction of the carotid arteries. A total of 25.41% of the patients were given an aortobi-iliac bypass., Results: During the first 30 days, 13 patients (10.7%) had 17 cardiac complications. The most common complication was the new onset of atrial fibrillation (35.3%). During the first 10 days, 10 patients had 1 complication and 2 patients had 2 cardiac events, while 1 patient had 3 complications. By comparing combinations of scores and markers, it was shown that revised cardiac risk index (RCRI) + Vascular Portsmouth Physiological and Operative Severity Score (V-POSSUM) + hsTnI and RCRI + V-POSSUM + hsTnI + NT-proBNP with 100% sensitivity, > 80% specificity had the best discriminatory ability (AUC 0.924 and 0.933, respectively; p < 0.001 for both models) for cardiac complications during the 30 days after surgery., Conclusion: Combinations of traditional preoperative risk factors and scores can enhance the assessment of major adverse cardiac events (MACE) in patients preparing for large vascular surgery. Using only one risk score in these patients seems to be underperforming in preoperative risk assessment., (© 2018 The Author(s) Published by S. Karger AG, Basel.)

Published
2019
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42. A Risk Stratification Model for Cardiovascular Complications during the 3-Month Period after Major Elective Vascular Surgery.

Author

Golubovic M, Stanojevic D, Lazarevic M, Peric V, Kostic T, Djordjevic M, Zivic S, and Milic DJ

Subjects
Aged, Biomarkers, C-Reactive Protein analysis, Elective Surgical Procedures, Female, Heart Diseases, Humans, Male, Middle Aged, Natriuretic Peptide, Brain analysis, Peptide Fragments, Percutaneous Coronary Intervention, Predictive Value of Tests, Prospective Studies, Risk Factors, Risk Assessment, Vascular Surgical Procedures adverse effects
Abstract

Introduction: The Revised Cardiac Risk Index (RCRI) is an extensively used simple risk stratification tool advocated by the European Society of Cardiology and European Society of Anesthesiology (ESC/ESA)., Purpose: The aim of this study was to find the best model for predicting 3-month cardiovascular complications in elective major vascular surgical patients using preoperative clinical assessment, calculation of the RCRI and Vascular Physiological and Operative Severity Score for the enumeration of mortality and morbidity (V-POSSUM) scores, and the preoperative levels of N-terminal brain natriuretic peptide (NT pro-BNP), high-sensitivity troponin I (hs TnI), and high-sensitivity C-reactive protein (hs CRP)., Materials and Methods: We included 122 participants in a prospective, single-center, observational study. The levels of NT pro-BNP, hs CRP, and hs TnI were measured 48 hours prior to surgery. During the perioperative period and 90 days after surgery the following adverse cardiac events were recorded: myocardial infarction, arrhythmias, pulmonary edema, acute decompensated heart failure, and cardiac arrest., Results: During the first 3 months after surgery 29 participants (23.8%) had 50 cardiac complications. There was a statistically significant difference in the RCRI score between participants with and without cardiac complications. ROC analysis showed that a combination of RCRI with hs TnI has good discriminatory power (AUC 0.909, p<0,001). By adding NT pro-BNP concentrations to the RCRI+hs TnI+V-POSSSUM combination we obtained the model with the best predictive power for 3-month cardiac complications (AUC 0.963, p<0,001)., Conclusion: We need to improve preoperative risk assessment in participants scheduled for major vascular surgery by combining their clinical scores with biomarkers. Therefore, it is possible to identify patients at risk of cardiovascular complications who need adequate preoperative diagnosis and treatment.

Published
2018
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43. Predictors of Quality of Life Improvement after 2 Years of Coronary Artery Bypass Surgery.

Author

Peric V, Stolic R, Jovanovic A, Grbic R, Lazic B, Sovtic S, and Borzanovic M

Subjects
Aged, Comorbidity, Coronary Artery Disease epidemiology, Coronary Artery Disease physiopathology, Coronary Artery Disease psychology, Cost of Illness, Elective Surgical Procedures, Female, Genetic Predisposition to Disease, Health Status, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Factors, Serbia epidemiology, Sex Factors, Surveys and Questionnaires, Time Factors, Treatment Outcome, Coronary Artery Bypass adverse effects, Coronary Artery Disease surgery, Quality of Life
Abstract

Purpose: The aim was to examine the predictors of improvement of quality of life after 2 years of coronary artery bypass grafting (CABG)., Methods: In all, 208 patients who underwent the elective CABG at the Institute for Cardiovascular Diseases Dedinje in Belgrade were contacted and examined 2 years after the surgery. All patients completed Nottingham Health Profile Questionnaire part one., Results: Two years after CABG, quality of life (QOL) in patients was significantly improved in all sections compared to preoperative period. Independent predictors of QOL improvement after 2 years of CABG were found to be serious angina under sections of physical mobility [p = 0.003, odds ratio (OR) = 1.76, 95% confidence interval (CI) 1.21-2.55], energy (p = 0.01, OR = 1.63, 95% CI: 1.11-2.38), sleep (p = 0.005, OR = 1.65, 95% CI: 1.16-2.35), pain (p <0.001, OR = 2.43, 95% CI: 1.57-3.77), absence of hereditary load in energy section (p = 0.002, OR = 0.35, 95% CI: 0.18-0.68), male sex in the sleep section (p = 0.03, OR = 0.43, 95% CI: 0.20-0.93), and absence of diabetes in pain section (p = 0.006, OR = 0.27, 95% CI: 0.10-0.68)., Conclusion: Predictors of improvement of QOL after 2 years of CABG are serious angina, absence of hereditary load, male sex, and absence of diabetes.

Published
2017
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44. Quality of Life in Patients of Different Age Groups before and after Coronary Artery By-Pass Surgery.

Author

Peric V, Jovanovic-Markovic S, Peric D, Rasic D, Novakovic T, Dejanovic B, and Borzanovic M

Subjects
Age Factors, Aged, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Coronary Artery Bypass, Quality of Life
Abstract

Purpose: The study evaluates the changes in quality of life (QOL) six months after coronary artery bypass grafting (CABG) related to the patients' age., Methods: The total of 243 consecutive patients completed the Nottingham Health Profile Questionnaire part 1 before and six months after CABG. Postoperative questionnaire was completed by 226 patients. Patients were divided into four examined groups (<50, 50-59, 60-69 and ≥70 years), according to their age., Results: Six months after CABG, the quality of life in different sections has been significantly improved in most patients.The analysis of the relation between the age and the changes in QOL of patients six months after CABG showed a significant correlation among the patients' age and the improvement of QOL in the sections of physical mobility (r = 0.18, p = 0.008), social isolation (r = 0.17, p = 0.01) and energy ( r = 0.21, p = 0.002). The most prominent improvement was found in older patients. The age was not an independent predictor of QOL deterioration after CABG., Conclusions: The most noticeable improvement of QOL six months after CABG was found in older patients. Age is not the independent predictor of deterioration of QOL after CABG.

Published
2015
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45. Temporal changes in plasma brain natriuretic peptide levels during exercise stress-echocardiography in patients with dilated cardiomyopathy.

Author

Peric V, Jovanovic A, Sovtic S, Stolic R, Djikic D, and Otasevic P

Subjects
Biomarkers blood, Cardiomyopathy, Dilated diagnostic imaging, Cardiomyopathy, Dilated physiopathology, Exercise Test methods, Female, Follow-Up Studies, Heart Ventricles diagnostic imaging, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Time Factors, Cardiomyopathy, Dilated blood, Echocardiography, Stress methods, Heart Ventricles physiopathology, Myocardial Contraction, Natriuretic Peptide, Brain blood, Ventricular Function, Left physiology
Abstract

The aim of this study was to evaluate temporal changes in brain natriuretic petide (BNP) levels during exercise stress-echocardiography in patients with dilated cardiomyopathy with respect to the left ventricular contractile reserve. We studied 55 consecutive patients with dilated cardiomyopathy (mean age, 55 ± 10 years, 49 (89.1%) male). All patients underwent exercise stress-echocardiography on a treadmill using the modified Bruce protocol. Contractile reserve was assessed by measuring changes in the wall motion score index (ΔWMSI) at rest and and at peak exercise. Levels of BNP were measured at rest, in the first minute, and after 20 minutes following termination of the stress test. Thirty-six patients had preserved left ventricular contractile reserve and 19 patients did not. Patients with preserved left ventricular contractile reserve showed a continuous rise in BNP levels from baseline to peak exercise and to 20 minutes following exertion (83.95 ± 108.51 versus 105.89 ± 116.00 versus 110.95 ± 119.70 ng/L, P < 0.001, respectively). On the other hand, patients without preserved left ventricular contractile reserve showed a decline in BNP levels at peak exercise as compared to baseline (335.49 ± 693.11 versus 320.08 ± 562.60 P = 0.031). ΔBNP was positively correlated with preserved contractile reserve (r = 0.46, P = 0.03) and lower NYHA class (r = -0.65, P = 0.001) in patients in whom baseline LVEF was lower than 20%. Multivariate analysis identified only WMSI at rest (beta -3.365, P = 0.008, 95 CI 0.03 to 0.411) as an independent predictor of left ventricular contractile reserve.The increase in BNP levels during exercise stress-echocardiography is associated with preserved left ventricular contractile reserve in patients with dilated cardiomyopathy.

Published
2014
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46. Nutrition parameters as hemodialysis adequacy markers.

Author

Stolic R, Trajkovic G, Stolic D, Peric V, and Subaric-Gorgieva G

Abstract

Background and Aim: The nutritive status has significant role in improving the quality of life of dialysis' patients. The aim of this study was to find out if there is any correlation of the anthropometric parameters and markers of nutrition with the adequacy of HD., Methods: The investigation was organized as a clinical, cross sectional study. Demographic characteristics, co-morbid conditions, smoking, dialysis duration and blood pressure were recorded. Serum total protein, albumin, ferritin and blood-lipids were measured as biochemical markers of nutritional status.One hundred and forty patients, 82 (58.6%) male, and 58 (41.4%) female, 55±12.59 years, were dividied into two groups. Group A consisted of 44 patients (14 women and 30 men) received the recommended hemodialysis dose (Kt/V ≥ 1.2), while the Group B consisted of 96 patients (69 males and 27 females) received non-adequate hemodialysis dose (Kt/V < 1.2)., Results: Patients with adequate hemodialysis had been longer on dialysis in correlation with the group of patients with non-adequate hemodialysis (73 ± 56.4 vs. 44 ± 50.1 months; p: 0.004). Group A and group B presented significant differences in the number of leukocytes (p: 0.027), and hemoglobin (p: 0.047), potassium (p: 0.038) and C-reactive protein level (p: 0.048) as well as in serum total protein (69 ± 4.63 vs. 65 ± 5.74 g/L; p < 0.0001) and albumin (38 ± 2.99 vs. 29 ± 4.4 g/L; p: 0.047). Pearsons correlation of factors that may have impact on hemodialysis adequacy indicated a significant relation between serum total protein and the index of hemodialysis adequacy (r: 0.21; p: 0.0446)., Conclusions: All investigated anthropometric parameters and protein status showed significantly higher values in patients with adequate hemodialysis quality (Group A). The Group B showed higher levels of CRP and lower values of hemoglobin.

Published
2010

47. Quality of life in patients related to gender differences before and after coronary artery bypass surgery.

Author

Peric V, Borzanovic M, Stolic R, Jovanovic A, Sovtic S, Djikic D, Marcetic Z, and Dimkovic S

Subjects
Aged, Elective Surgical Procedures, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk Assessment, Risk Factors, Sex Factors, Surveys and Questionnaires, Treatment Outcome, Coronary Artery Bypass adverse effects, Health Status Disparities, Quality of Life
Abstract

Objectives: The different aspects of quality of life (QOL) in patients of different sex structure have been examined as well as the presumption that sex structure could be a predictor of QOL changes after coronary artery bypass grafting (CABG)., Methods: The study included 243 consecutive patients who underwent an elective CABG. The QOL analysis was performed by using structured interviews with the Nottingham Health Profile (NHP) questionnaire part 1., Results: Compared to men, women had worse preoperative QOL (in all sections except the section of sleep) and worse postoperative QOL (in all sections). Six months after CABG the QOL statistically improved in men and in women. Multivariate analysis showed that being female was an independent predictor of QOL worsening in section of pain [P=0.001, odds ratio (OR)=3.93, 95% confidence interval (CI) 1.74-8.88]., Conclusions: Compared to men, women have worse preoperative and postoperative QOL. Female sex was an independent predictor of QOL worsening six months after CABG.

Published
2010
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48. Association of metabolic changes with mortality of patients treated by peritoneal dialysis or hemodialysis.

Author

Stolic R, Trajkovic G, Jovanovic A, Peric V, Stolic D, Sovtic S, and Subaric-Gorgieva G

Subjects
Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Renal Dialysis mortality, Renal Insufficiency therapy, Survival Rate, Peritoneal Dialysis mortality, Renal Insufficiency metabolism, Renal Insufficiency mortality
Abstract

Aim: The aim of this study was to determine the survival of patients treated by peritoneal dialysis (PD) and hemodialysis (HD) and to detect any association with the type of metabolic changes., Methods: The outcome of clinical treatment of 407 dialysis patients was analyzed over a 4-year period. This included the demographic characteristics, the duration of dialysis, smoking, residual renal function, existence of metabolic syndrome and malnutrition, waist girth, body mass index (BMI), comorbidity, and routine biochemical parameters., Results: The overall mortality of the treated patients during the 4-year period was 53%, 37% for HD patients and 65% for PD patients. Metabolic syndrome was the dominant metabolic disorder affecting more than half of the HD patients, as well as being a predictive mortality parameter (beta = 0.560; p = 0.045). The PD-treated patients had an equal prevalence of metabolic syndrome and malnutrition, whereas statistically significant predictors of mortality outcome were BMI (beta = 0.088; p = 0.002) and waist girth (beta = 0.023; p = 0.031). The median survival value was significantly higher for HD patients [108 months; 95% confidence interval (CI) 65-151]. Residual renal function in PD patients was significantly related to mortality (p = 0.045)., Conclusion: Metabolic syndrome is a predictive parameter of mortality for HD patients, whereas for PD patients it is the waist girth and BMI. Preserved residual renal function in patients on PD is an important factor in reducing mortality.

Published
2010
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49. Intraventricular textiloma with granuloma formation following third ventricle colloid cyst resection - a case report.

Author

Lavrnic S, Stosic-Opincal T, Gavrilovic S, Grujicic D, Peric V, Gavrilov M, Milenkovic R, and Cvetkovic-Dozic D

Subjects
Cotton Fiber, Female, Granuloma, Foreign-Body surgery, Humans, Middle Aged, Surgical Sponges adverse effects, Brain Neoplasms surgery, Central Nervous System Cysts surgery, Granuloma, Foreign-Body diagnosis, Granuloma, Foreign-Body etiology, Hemostasis, Surgical adverse effects, Third Ventricle
Abstract

Despite precautions, cotton and gauze pads used for dissection or to achieve haemostasis during neurosurgical procedures can inadvertently be left behind and result in clinically symptomatic or asymptomatic and radiologically apparent mass lesion, sometimes referred to as "textilomas" or "gossypibomas", often mimicking recurrent tumour or abscess on neuroimaging studies. We report the neuroimaging evaluation, including computed tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (H1-MRS), in a case of textiloma developing after the treatment of a third ventricle colloid cyst., ((c) Georg Thieme Verlag KG Stuttgart, New York.)

Published
2009
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50. Predictors of worsening of patients' quality of life six months after coronary artery bypass surgery.

Author

Peric V, Borzanovic M, Stolic R, Jovanovic A, Sovtic S, Dimkovic S, and Marcetic Z

Subjects
Aged, Confidence Intervals, Coronary Artery Disease mortality, Coronary Artery Disease psychology, Diabetes Complications diagnosis, Female, Health Status Indicators, Humans, Male, Middle Aged, Odds Ratio, Postoperative Complications diagnosis, Predictive Value of Tests, Prospective Studies, Risk Assessment, Risk Factors, Sex Factors, Stroke Volume, Surveys and Questionnaires, Time Factors, Coronary Artery Bypass adverse effects, Coronary Artery Disease surgery, Quality of Life psychology
Abstract

Background: The possibility to predict the change in (the) quality of life after coronary artery bypass surgery (CABG) being unclear, the aim was to evaluate the change of quality of life and predictors of worsening of quality of life in patients six months after CABG., Methods: We studied 208 consecutive patients, who underwent elective CABG. The Nottingham Health Profile Questionnaire part 1 was used as the model for quality of life determination. The questionnaire contains 38 subjective statements divided into six sections: physical mobility, social isolation, emotional reaction, energy, pain, and sleep. We distributed the questionnaire to all patients before CABG and six months after CABG. One hundred ninety-two patients filled in the postoperative questionnaire., Results: The comparison between mean preoperative and postoperative scores showed an improvement in all sections of quality of life (p < 0.001). New York Heart Association functional class was significantly improved after CABG (2.23 +/- 0.65 vs. 1.58 +/- 0.59, p<0.001). Independent predictors of patients worsened by CABG were as follows: female gender in the pain section (p = 0.002; OR = 4.27; CI 1.74-10.47), diabetes mellitus in the physical mobility section (p = 0.003; OR = 8.09; CI 2.04-32.09), low ejection fraction in the physical mobility (p = 0.047; OR = 0.73; CI 0.56-0.95) and emotional reaction (p = 0.03; OR = 0.86; CI 0.60-0.93) sections, and postoperative complications in the social isolation (p = 0.002; OR = 4.63; CI 1.79-11.99), sleep (p = 0.03; OR = 2.71; CI 1.12-6.51), and pain (p = 0.005; OR = 3.39; CI 1.45-7.97) sections., Conclusion: The predictive factors for quality of life worsening six months after CABG are female gender, diabetes mellitus, low ejection fraction, and the presence of postoperative complications.

Published
2008
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