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Some novel Di (6/8-chloro-8/6-Chromonyl) Methyl ethers i.e. Bischromones -I & II were synthesized by oxidative cyclisation of Di (5'-chloro-4'/2'-hydroxy-3'-chalconyl) methyl ethers i.e. Bischalcones- I & II and screened for antifungal activity.

An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.

We document an efficient and cost‐effective synthesis of ramipril 1 utilizing (i) an environmentally benign process for the esterification of racemic 2‐aza‐bicyclo‐[3.3.0]‐octane‐3‐carboxylic acid hydrochloride 2 using boric acid as a catalyst and (ii) a robust resolution process for the synthesis of 3a by means of inexpensive and recyclable L‐(+)‐mandelic acid as key steps.

An efficient and environmentally benign boric acid catalyzed protocol for the transesterification of ethyl acetoacetate with a variety of primary and secondary alcohols in good to excellent yields is described. The versatility of this transformation is demonstrated with problematic substrates such as propargyl alcohol and allyl alcohol, which are known to undergo Carroll rearrangement during transesterification.

Using (S)-1-amino-2-(methoxymethyl)pyrrolidine (SAMP) (II) as chiral auxiliary, a new and innovative route to title compound (VIII), a key intermediate in the synthesis of the ACE inhibitor ramipril, is described.

We document an efficient and cost‐effective synthesis of ramipril 1 utilizing (i) an environmentally benign process for the esterification of racemic 2‐aza‐bicyclo‐[3.3.0]‐octane‐3‐carboxylic acid hydrochloride 2 using boric acid as a catalyst and (ii) a robust resolution process for the synthesis of 3a by means of inexpensive and recyclable L‐(+)‐mandelic acid as key steps.

An efficient and environmentally benign boric acid catalyzed protocol for the transesterification of ethyl acetoacetate with a variety of primary and secondary alcohols in good to excellent yields is described. The versatility of this transformation is demonstrated with problematic substrates such as propargyl alcohol and allyl alcohol, which are known to undergo Carroll rearrangement during transesterification.

Poet-graduate Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-481602 Chemistry Department. Marathwada University, Aurangabad-481 004 Manuscript received 19 February 1988, revised 16 May 1988, accepted29 July1988 Synthesis of some New Halogenohydroxymethyl flavones.

Department of Chemistry, Yeshwant College, Nanded 431 602, Maharashtra State, India Manuscript received 6 January 1977, revised 11 August 1978,accepted 20 November 1978 Study of Some Reactions on AcetophenoneDerivatives II